What's New in Cardiac MRI? — May 25, 2026
AI-summarised digest of 63 PubMed articles on Cardiac MRI published in the last 7 days.
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What’s New in Cardiac MRI?
May 25, 2026 · 63 articles · 15 research themes · covering May 18, 2026 – May 25, 2026
Overview
Across this week’s set of studies, cardiac MRI (CMR) is increasingly positioned not only as a diagnostic tool but as a quantitative, scalable platform—spanning new acquisition protocols (e.g., ultrafast 3D CMR), standardized tissue mapping approaches, and automated/annotation-free pipelines for ROI localization and measurement. Several papers also tackle cross-modality consistency (e.g., CMR vs echocardiography LVEF discordance) and reproducibility, while engineering work (image registration) supports faster, more efficient imaging pipelines.
A second dominant theme is mechanistic tissue characterization and risk stratification using CMR-derived biomarkers of fibrosis and remodeling. Multiple studies link myocardial tissue metrics (T1/ECV, LGE patterns/texture, diffuse fibrosis distribution, and myocardial elasticity) to clinical outcomes in diverse settings: post–tetralogy of Fallot repair, end-stage hypertrophic cardiomyopathy, severe aortic stenosis, and post–STEMI remodeling phenotypes. Complementing this, invasive physiology studies (angio-IMR, coronary wedge pressure during occlusion, and CMR-defined microvascular obstruction) emphasize earlier detection of microvascular injury—often with prognostic implications that vary by patient phenotype (e.g., obesity).
Finally, the digest highlights a rapid convergence of multimodality imaging and AI. Vision-language and multimodal models learn from CMR images and reports to enable zero-shot understanding and text-driven outcome prediction, while AI-assisted triage and CMR-informed ECG modeling aim to accelerate clinical decision-making. In parallel, multimodality diagnostic workflows remain central for complex inflammatory/infiltrative disease (sarcoidosis, myocarditis, autoimmune myocarditis, eosinophilic heart disease) and for cardiac masses/tumors/metastases where echocardiography can be insensitive. Together, these studies suggest a field moving toward earlier, more precise, and more operationally scalable cardiovascular phenotyping—grounded in CMR and increasingly augmented by AI and integrated PET/CT, CT, and invasive measurements.
MRI/CMR-guided Endovascular and Interventional Procedures
Feasibility of Magnetic Resonance Imaging-Guided Pulmonary Artery Stenting in a Commercial Wide-Bore 0.55-T Scanner.
The study assessed the feasibility of real-time MRI-guided pulmonary artery (PA) stenting in a juvenile swine model using a commercial wide-bore 0.55-T MRI system with ferumoxytol-enhanced imaging. PA stent deployment was successful in 7 of 10 pigs, with all successful cases occurring after switching vascular access from femoral to external jugular venous access, and real-time gradient-echo imaging provided adequate visualization for catheter navigation and stent delivery. These findings support the scientific feasibility of radiation-free MRI guidance for complex endovascular PA interventions, potentially improving safety in future translational workflows.
Liu Y, Kelly JM, Swinning J et al. · JACC. Basic to translational science · (2026) · View on PubMed ↗ · Free PDF ↗
Cardiac MRI Quantification Methods, Standardization, and Automation
Fast and scalable annotation-free LV-centered ROI localisation in stress perfusion cardiac MRI.
The study developed and evaluated an annotation-free pipeline to localize left ventricle (LV)-centered regions of interest (ROIs) in stress perfusion cardiac MRI, using raw perfusion frames rather than manually labeled training data. The key finding was that combining Fast Fourier Transform (FFT)-based localization with Sobel edge refinement and a heuristic fallback produced consistent LV-centered circular ROIs quickly and at scale without task-specific annotations. This is significant because it can reduce the labeling burden for stress perfusion CMR analysis and enable more scalable, automated downstream quantification in clinical and research workflows.
Kalashami MP, Fagioli A, Marini MR et al. · Computers in biology and medicine · (2026) · View on PubMed ↗
Analysis of OSCE-based clinical competency assessment among critical care medicine residents in Zhejiang Province, China: a multicenter retrospective cohort study.
This multicenter retrospective cohort study analyzed Objective Structured Clinical Examination (OSCE) performance among 175 critical care medicine residents across seven standardized residency training bases in Zhejiang Province, China (2023–2025). The key finding was that OSCE scores varied by training base, highlighting educational gaps that differed across sites. This is clinically and educationally significant because it provides actionable evidence to target residency training optimization for critical care competencies.
Chen C, Mao W, Cai K et al. · BMC medical education · (2026) · View on PubMed ↗
Sustained and discontinued operational changes to ethics committees in the post-pandemic era: a qualitative study in Kenya.
This qualitative study explored ethics committee (EC) operational changes retained or discontinued after the COVID-19 pandemic in Kenya. The key finding was that some pandemic-era EC process adaptations were sustained while others were dropped, reflecting how ECs balanced rapid review needs during public health emergencies with longer-term oversight requirements. This is significant because it informs how research governance systems can be redesigned to improve resilience and efficiency for future public health emergencies.
Kebenei E, Cheruiyot D, Bukusi EA et al. · BMC medical ethics · (2026) · View on PubMed ↗ · Free PDF ↗
Investigation of Concordance between Artificial Intelligence and Manual Measurements of the Cardiac Parameters in Cardiac Magnetic Resonance Imaging.
This external validation study assessed concordance between a commercially available AI system and manual measurements for biventricular CMR parameters and per-segment left ventricular wall thickness (LVWT) in 100 healthy Chinese volunteers. The AI-derived measurements demonstrated agreement with manual quantification across biventricular metrics and segmental LVWT, supporting reproducibility in a prospective single-center setting independent from training data. This is significant for scaling CMR analysis by enabling more reliable automated quantification in routine clinical workflows.
Tang R, Xu Z, Huang Z et al. · Journal of imaging informatics in medicine · (2026) · View on PubMed ↗
T1 Mapping In Differentiating Healthy And Pathological Myocardium.
This retrospective 1.5T CMR study compared native T1 mapping measurement locations/techniques across 61 non-ischemic dilated cardiomyopathy (NIDCM) patients, 60 hypertrophic cardiomyopathy (HCM) patients, and 22 controls to standardize diagnostic T1 mapping. The key finding was identification of an optimal native T1 mapping approach (location and technique) that best differentiated healthy myocardium from pathological myocardium in NIDCM and HCM. Standardizing native T1 mapping improves reproducibility and diagnostic accuracy for myocardial characterization in clinical CMR workflows.
Bozer Uludağ S, Ünal S, Peker E et al. · Anatolian journal of cardiology · (2026) · View on PubMed ↗ · Free PDF ↗
Comparison of Left Ventricular Ejection Fraction and Disease Classification by Cardiac Magnetic Resonance and Echocardiography.
This retrospective study compared left ventricular ejection fraction (LVEF) measurements and resulting heart failure classification discordance between cardiac magnetic resonance (CMR) and transthoracic echocardiography (TTE) in 1213 patients who underwent both within 1 week. It found that LVEF values differed between modalities and that specific imaging characteristics were associated with discordance in classification using European Society of Cardiology thresholds (50% and 35%). The clinical significance is that modality choice and identifiable imaging factors may affect guideline-based LVEF categorization and downstream management decisions.
Le Y, An J, Liang L et al. · The American journal of cardiology · (2026) · View on PubMed ↗
Measurement of quality of stroke care with national electronic health records: a prospective cohort study during and after the COVID-19 pandemic.
This prospective cohort study evaluated whether linked national electronic health records (EHRs) can measure stroke care quality in England before and after the COVID-19 pandemic, using 425,675 adults and datasets including SSNAP, primary/secondary care, medication dispensing, and mortality records. It found that linked EHRs enabled assessment of quality metrics not routinely captured—such as secondary prevention medication dispensing and a proxy for disability-time spent at home (“home-time”)—across the pandemic transition. The scientific significance is that scalable EHR linkage can support ongoing, population-level monitoring of stroke care quality and outcomes.
Farrell J, Nolan J, Lambert R et al. · BMJ open · (2026) · View on PubMed ↗ · Free PDF ↗
Determining adverse childhood experiences and their association with substance use among young adults in universities and colleges in Mombasa County, Kenya.
This cross-sectional study assessed adverse childhood experiences (ACEs) and their association with substance use (alcohol, tobacco products, and illicit drugs) among 849 young adults in universities and colleges in Mombasa County, Kenya. It examined whether participants who reported ACE exposure were more likely to report substance use, using randomly sampled participants from 11 higher learning institutions. The public health significance is identifying ACE-related risk patterns that could guide targeted prevention and intervention programs for substance use in Kenyan university populations.
Odero M, Kihoro RW, Mbogo PW et al. · Substance abuse treatment, prevention, and policy · (2026) · View on PubMed ↗ · Free PDF ↗
AI for Cardiac Imaging and Multimodal Prediction
Contrastive language image pretraining for a cardiac magnetic resonance image embedding with zero-shot capabilities.
This Nature Communications study developed CMR-CLIP, a contrastive vision-language pretraining model that learns embeddings between CMR images and associated reports using a dataset of 11,028 studies treated as video-like inputs. The model achieved zero-shot capabilities for cardiac MRI understanding by aligning CMR image embeddings with text from reports without requiring task-specific labeled data. This is significant because it reduces dependence on large labeled CMR datasets and enables more flexible downstream clinical and research applications of CMR embeddings.
Nakashima M, Qiu J, Huang P et al. · Nature communications · (2026) · View on PubMed ↗ · Free PDF ↗
Relationship between hemodynamic forces based on CMR and major adverse cardiac events in cancer patients treated with anti-PD-1/PD-L1 immune checkpoint inhibitors.
This prospective multicenter study examined whether cardiovascular magnetic resonance (CMR)-derived hemodynamic forces (HDFs) relate to major adverse cardiac events (MACE) in cancer patients receiving anti–PD-1/PD-L1 immune checkpoint inhibitors. Patients with normal baseline echocardiograms underwent CMR at ~12 weeks after starting immunotherapy, and the study tested associations between CMR HDF metrics and subsequent MACE. The scientific significance is identifying CMR biomarkers that could enable earlier detection of ICI-related cardiotoxicity risk in oncology patients.
Gao D, Wang Y, Shi Y et al. · BMC medical imaging · (2026) · View on PubMed ↗ · Free PDF ↗
Layer-specific fast strain-encoded cardiovascular magnetic resonance in suspected acute coronary syndrome: a prospective study.
In a prospective single-center observational study, patients presenting with chest pain and low-to-intermediate pretest probability for major adverse cardiac events (MACE) underwent rapid layer-specific fast strain-encoded cardiovascular magnetic resonance (fSENC) before further therapy. The key finding was that layer-specific strain patterns from fSENC CMR can help identify ischemic causes among suspected acute coronary syndrome presentations. Scientifically and clinically, this supports faster, more targeted CMR-based triage for ACS by linking myocardial mechanics to ischemic pathology.
Weberling LD, Siry D, Haney AC et al. · Clinical research in cardiology : official journal of the German Cardiac Society · (2026) · View on PubMed ↗ · Free PDF ↗
Multimodal Artificial Intelligence for Early Detection and Precision Management of Inflammatory and Infiltrative Cardiomyopathies.
This article reviewed how multimodal artificial intelligence (AI) can enable early detection and precision management of inflammatory and infiltrative cardiomyopathies, including cardiac sarcoidosis, transthyretin amyloidosis, and autoimmune myocarditis. It proposes integrating ECG, echocardiography, cardiac MRI, PET/scintigraphy, biomarkers, and electronic health record (EHR) features to improve diagnostic suspicion, tissue-based phenotyping, and risk-directed triage. The clinical significance is earlier recognition of these often underdiagnosed conditions and more timely, targeted management to prevent progression to advanced myocardial dysfunction.
Adrejiya P, Alkhatib DA, Aljaroudi W · Current problems in cardiology · (2026) · View on PubMed ↗
A composable multimodal framework for cine CMR-text-driven prediction of heart failure outcomes.
This study proposed and evaluated a composable multimodal framework for cine cardiac MRI (CMR) text-driven prediction of heart failure outcomes. The approach integrates multimodal algorithmic components to better capture the multifactorial nature of heart failure and improve outcome prediction compared with more limited single-modality strategies. Scientifically, it supports using cine CMR plus text-driven representations to enhance precision risk stratification for heart failure prognosis.
Chen J, Sun J, Wang X et al. · Physiological measurement · (2026) · View on PubMed ↗ · Free PDF ↗
CMR Physics/Engineering and Image Acquisition Innovations
Validation of a novel three-dimensional ultrafast cardiac magnetic resonance imaging protocol in adolescents: a non-inferiority study compared with the two-dimensional gold standard.
This study validated a novel three-dimensional (3D) ultrafast cardiac magnetic resonance (CMR) protocol against a conventional two-dimensional (2D) CMR gold standard in 39 adolescents (mean age 12.2±2.6 years) at 3 Tesla. The 3D ultrafast protocol was non-inferior to the 2D protocol for assessing cardiac function, strain, and tissue characterization while reducing acquisition burden (e.g., breath-holds). This supports broader pediatric feasibility of ultrafast 3D CMR for routine evaluation and monitoring of myocardial disease without sacrificing diagnostic performance.
Chen W, Liu S, Li W et al. · Pediatric radiology · (2026) · View on PubMed ↗ · Free PDF ↗
Dynamic right ventricular and atrial volume responses to exercise in endurance-trained and untrained healthy individuals.
This PLoS ONE study used exercise real-time cardiac magnetic resonance (CMR) to quantify dynamic right ventricular (RV) and atrial (LA/RA) volume responses during exercise in 20 endurance-trained (ET) and 13 untrained (UT) healthy individuals while controlling for respiratory effects. It compared how the four-chamber heart adapts to exercise between ET and UT groups under standardized respiratory conditions. The significance is improved physiological characterization of RV and atrial reserve during exercise, which may refine interpretation of CMR functional studies in health and disease.
Östenson B, Ostenfeld E, Edlund J et al. · PloS one · (2026) · View on PubMed ↗ · Free PDF ↗
Fourier-Net+: Band-Limited Spatial Representation for Efficient Medical Image Registration.
This engineering study developed Fourier-Net+ for efficient medical image registration using a band-limited spatial representation, targeting unsupervised deformable registration of high-resolution volumetric images. It found that deterministic Fourier-domain band-limiting for down-/up-sampling plus a parameter-free, model-driven decoder can learn a low-dimensional displacement-field representation while reducing computational cost compared with full-resolution dense displacement prediction. The scientific significance is faster, more resource-efficient registration with broad modality compatibility for medical imaging pipelines.
Jia X, Thorley A, Gomez A et al. · IEEE transactions on neural networks and learning systems · (2026) · View on PubMed ↗
Cardiac Sarcoidosis: PET/CMR Diagnostic Optimization
FDG PET for cardiac sarcoidosis: Protocol optimization, quantification, pitfalls, and multimodality imaging integration.
This Seminars in Nuclear Medicine review summarizes how FDG PET should be optimized and quantified for cardiac sarcoidosis (CS), including common pitfalls and how PET findings integrate with echocardiography and cardiac MRI within probabilistic multimodality diagnostic frameworks. It emphasizes protocol elements (e.g., dietary preparation and imaging/quantification strategies) that affect interpretability and recommends multimodality integration to improve diagnostic accuracy and management decisions. Clinically, the review provides practical guidance to reduce false positives/negatives and standardize FDG PET use in suspected CS.
Wopperer SB, Kronzer E, Ivare J et al. · Seminars in nuclear medicine · (2026) · View on PubMed ↗
Inflammatory and Autoimmune Cardiac Disease (Myocarditis, IIM, SLE, Eosinophilic)
Serum vs. tissue cytokine dysregulation in SLE-associated myocarditis: a hypothesis from an African cohort perspective.
This hypothesis-driven study examined an African mixed-ancestry cohort of systemic lupus erythematosus (SLE) patients to correlate cardiac tissue cytokine dysregulation with serum cytokines and standard-of-care cardiac MRI (CMR) findings in lupus-associated myocarditis. Patients with SLE myocarditis (SLE-M) showed distinct cardiac tissue inflammatory cytokine profiles that aligned with (and helped explain) differences in SOC biomarkers and CMR measures compared with SLE without myocarditis and controls. Scientifically, the work links tissue-level immune activation to clinically measurable imaging/serologic signals, potentially informing mechanism-based biomarkers for lupus myocarditis.
Ollewagen T, Toit RD, Karamchand S et al. · Molecular medicine (Cambridge, Mass.) · (2026) · View on PubMed ↗ · Free PDF ↗
Current state of knowledge on the epidemiology, aetiology, diagnosis, and management of heart involvement in eosinophilia. A Clinical Consensus Statement of the ESC Working Group on Myocardial & Pericardial Diseases.
This ESC Working Group clinical consensus statement reviews the epidemiology, causes, diagnosis, and management of heart involvement in eosinophilia (eosinophilic heart disease). It highlights that cardiac involvement can occur even without peripheral eosinophilia and that biopsy of affected tissue may be essential to establish diagnosis in selected patients. The statement is significant for improving early recognition and guiding diagnostic and therapeutic strategies to reduce morbidity and mortality from eosinophil-associated cardiac disease.
Kuchynka P, Brucato A, Tschöpe C et al. · European journal of heart failure · (2026) · View on PubMed ↗
[Chagas cardiomyopathy].
This review article on Chagas cardiomyopathy synthesized evidence on how cardiovascular imaging detects chronic myocardial involvement in patients infected with Trypanosoma cruzi. It highlights that cardiac magnetic resonance (CMR) enables myocardial tissue characterization and fibrosis detection, complementing echocardiography’s functional assessment. The clinical significance is improved early detection and risk stratification of Chagas-related cardiomyopathy using imaging—particularly CMR fibrosis assessment.
Redzepi B, Mainta I, Jackson Y et al. · Revue medicale suisse · (2026) · View on PubMed ↗
Multimodality Imaging in Inflammatory Cardiac Disease.
This review studied how multimodality imaging is used to diagnose and manage inflammatory cardiac diseases—including myocarditis, cardiac sarcoidosis, infective endocarditis, and pericarditis—in clinical practice. It found that echocardiography (transthoracic and transesophageal) is first-line for conditions such as infective endocarditis and pericardial effusion, while cardiac MRI provides gold-standard tissue characterization for myocarditis, cardiac sarcoidosis, and pericardial inflammation and CT helps define anatomy (e.g., valves, abscesses, calcification). The clinical significance is improved diagnostic precision and treatment planning by matching the imaging modality to the specific inflammatory cardiac phenotype.
Mahmood A, Ramesh J, Patel DS et al. · Cardiology in review · (2026) · View on PubMed ↗
Elevated sST2 associates with cardiac involvement and declines after treatment in newly diagnosed patients with idiopathic inflammatory myopathies.
This longitudinal cohort study measured soluble suppression of tumorigenicity 2 (sST2) in newly diagnosed and established idiopathic inflammatory myopathy (IIM) patients, including 34 newly diagnosed IIM patients followed over 2 years, 109 established IIM patients, age- and gender-matched healthy controls, and rheumatoid arthritis controls. It found that elevated sST2 was associated with cardiac involvement and that sST2 levels declined after treatment in newly diagnosed patients. The clinical significance is that sST2 may serve as a biomarker for cardiac involvement and treatment response in IIM.
Hanna B, Lundberg IE, Ekwall AH et al. · Arthritis research & therapy · (2026) · View on PubMed ↗ · Free PDF ↗
Insights Into the Natural History of Recurrent Myocarditis, A Multicenter International Study (Re-Myo Study).
This multicenter international study investigated the natural history and outcomes of recurrent acute myocarditis (Re-AM) in 141 patients with biopsy-proven or cardiac magnetic resonance–proven recurrent myocarditis, compared with 372 patients with single acute myocarditis (S-AM). Re-AM patients had distinct clinical characteristics and worse outcomes, with the study’s primary composite endpoint including all-cause mortality, heart transplant, and major ventricular arrhythmias. The findings improve prognostic understanding of recurrent myocarditis and can inform risk stratification and follow-up strategies after recurrence.
Baggio C, Cannata A, Gasperetti A et al. · Journal of the American Heart Association · (2026) · View on PubMed ↗ · Free PDF ↗
Intravenous IRON supplementation in Heart Failure with Preserved Ejection Fraction and iron deficiency (IRON-HFpEF): a comprehensive phase II multicentre placebo-controlled randomised clinical trial.
The IRON-HFpEF phase II multicentre randomized placebo-controlled trial studied whether intravenous ferric carboxymaltose (FCM) improves cardiovascular function and exercise tolerance in patients with heart failure with preserved ejection fraction (HFpEF) and iron deficiency (ID) without ID-anaemia. In 45 HFpEF patients randomized to FCM versus placebo, mechanistic outcomes were assessed at baseline and 4 months using exercise right-heart catheterization, 6-minute walking distance (6MWD), cardiac MRI, and exercise calf muscle 31P-magnetic resonance spectroscopy. If effective, this approach would establish a clinically actionable strategy for targeting iron deficiency in HFpEF and clarify the physiological mechanisms linking iron repletion to exercise capacity.
van de Bovenkamp AA, Nassiri S, de Man FS et al. · European journal of heart failure · (2026) · View on PubMed ↗ · Free PDF ↗
Cardiac Sarcoidosis: Biopsy Limitations and Imaging-Based Diagnosis
[Cardiac sarcoidosis in 2026 : current perspectives].
This 2026 perspective article reviewed diagnostic strategies for cardiac sarcoidosis, focusing on patients with systemic sarcoidosis who develop symptomatic cardiac involvement (e.g., arrhythmias, heart failure, sudden cardiac death). It emphasizes that endomyocardial biopsy has limited sensitivity (~20%) and that advanced imaging—especially [18F]-FDG PET/CT and cardiac magnetic resonance (CMR)—is crucial for prompt and accurate detection. The significance is guiding clinicians toward imaging-based diagnosis and risk stratification when biopsy sensitivity is low.
Sritharan A, Hermann Kamani C, Lu H et al. · Revue medicale suisse · (2026) · View on PubMed ↗
Myocardial Fibrosis, Tissue Characterization, and Extracellular Volume (ECV/T1/LGE)
Prognostic Impact of LGE Granularity Using CMR in End‑Stage Hypertrophic Cardiomyopathy.
This retrospective study evaluated end-stage hypertrophic cardiomyopathy (HCM) patients (left ventricular ejection fraction <50%) to determine the prognostic impact of late gadolinium enhancement (LGE) granularity features on CMR, including location, extent, and pattern. Across patients referred for CMR at three French tertiary centers (2008–2024), the LGE granularity model stratified prognosis and provided prognostic information beyond standard end-stage HCM characterization. The results are significant because they suggest a more detailed CMR LGE texture approach can improve risk prediction in advanced HCM.
Hudelo J, Garot J, Toupin S et al. · Circulation. Cardiovascular imaging · (2026) · View on PubMed ↗
Prediction of Left Ventricular Systolic Dysfunction from ICU Electrocardiograms Using Vision Transformer Embeddings and Multimodal Features.
This retrospective study investigated whether left ventricular systolic dysfunction (LVEF ≤40%) can be predicted directly from 12-lead ICU electrocardiograms using Vision Transformer (ViT) embeddings pretrained on CMR data combined with conventional ECG features. In approximately 900 ICU admissions from a single tertiary center, the proposed multimodal models (Random Forest, XGBoost, and a focal-loss-trained shallow multilayer perceptron) aimed to classify reduced LVEF without waiting for echocardiography or CMR. Clinically, it could enable earlier identification of high-risk patients in the ICU by providing rapid, CMR-informed ECG-based estimates of LV systolic dysfunction.
Lenkowicz J, di Giorgi N · Studies in health technology and informatics · (2026) · View on PubMed ↗ · Free PDF ↗
Distribution of diffuse myocardial fibrosis is uneven and associated with left ventricular function in severe aortic stenosis.
This study investigated diffuse myocardial fibrosis (DMF) distribution and its relationship to left ventricular (LV) function in 43 patients with severe aortic stenosis using CMR and transthoracic echocardiography within 1 week before surgery. It found that DMF is unevenly distributed across the myocardium and that DMF burden/distribution is associated with worse LV function. The significance is that CMR quantification of DMF may help identify patients with more adverse remodeling and potentially inform prognosis and post-surgical reversibility expectations.
Holmberg E, Engvall J, Nylander E et al. · Open heart · (2026) · View on PubMed ↗ · Free PDF ↗
Glucose Disposal Rate: A Novel Measure of Insulin Resistance Associated With Myocardial Fibrosis and Incident Heart Failure.
This cohort study evaluated whether the estimated glucose disposal rate (eGDR), a surrogate measure of insulin resistance, is associated with myocardial fibrosis and incident heart failure in 6,025 participants from the MESA study free of heart failure at exam 2 (2002–2004). Lower eGDR (higher insulin resistance) was linked to greater myocardial fibrosis and higher risk of developing heart failure, using cardiac magnetic resonance imaging to quantify left ventricular function and fibrosis measures. These results suggest that eGDR can help identify cardiometabolic risk that translates into myocardial remodeling and future heart failure.
Bukhari S, Kwapong YA, Yanek LR et al. · Journal of the American Heart Association · (2026) · View on PubMed ↗ · Free PDF ↗
Associations of Metabolic Phenotypes with Cardiac Structure and Clinical Outcomes: Insights from the UK Biobank.
This UK Biobank analysis studied how metabolic phenotypes—metabolically healthy nonobese (MHN), metabolically healthy obese (MHO), metabolically unhealthy nonobese (MUN), and metabolically unhealthy obese (MUO)—relate to cardiac structure measured by cardiac magnetic resonance imaging (CMR) and to clinical outcomes over a median 5.1-year follow-up in 22,789 participants. Metabolically unhealthy and/or obese phenotypes showed more adverse CMR cardiac structural patterns and worse clinical outcomes than metabolically healthy nonobese individuals. The results support using combined obesity and metabolic status phenotyping to better predict cardiac remodeling and future cardiovascular risk.
Bogner B, Jung M, Reisert M et al. · The Journal of clinical endocrinology and metabolism · (2026) · 1 citations · View on PubMed ↗ · Free PDF ↗
Subclinical Origins of Cardiometabolic Risk in Indian Adolescents: A Cross-Sectional Study.
This cross-sectional study measured associations between body fat, hepatic fat, and cardiometabolic risk factors in apparently healthy Indian adolescents aged 11–16 years. Using MRI proton density fat fraction (PDFF) on a 3.0-T GE Signa Architect and whole-body fat by dual-energy X-ray absorptiometry (DXA), the investigators found that at least one cardiometabolic risk factor was present in 32.5% of participants (with additional associations reported in the full text). The results highlight subclinical cardiometabolic risk origins in youth and support MRI-based quantification of hepatic fat as a potential early marker for cardiometabolic risk stratification.
Hegde SG, Kankara SR, Raj JM et al. · Indian pediatrics · (2026) · View on PubMed ↗
Post-Myocardial Infarction Remodeling and Non-Infarcted Myocardium (NIM)
Rethinking Post-Infarction Remodeling: Identification and Validation of Data-Driven Cardiac MRI Phenotypes for Risk Stratification.
This prospective longitudinal study analyzed reperfused ST-elevation myocardial infarction (STEMI) patients to identify and validate data-driven cardiac magnetic resonance (CMR) remodeling phenotypes for risk stratification. Using unsupervised clustering of longitudinal CMR measures from a derivation cohort (n=337) and validation cohort (n=190), the authors found remodeling phenotypes that better predicted outcomes than conventional adverse LV remodeling definitions based on changes in LV end-diastolic volume index and ejection fraction. Scientifically, it supports phenotype-based CMR risk stratification after STEMI to improve prognostic accuracy beyond guideline-style volume/EF thresholds.
Xiang JY, Wu J, Zhao Y et al. · European heart journal. Cardiovascular Imaging · (2026) · View on PubMed ↗
Changes in myocardial elasticity derived from in-vivo cardiac MRI in a swine model of ischemic heart failure.
This in-vivo swine ischemic heart failure study used clinically relevant cardiac MRI to derive myocardial elasticity (secant modulus) from combined wall stress and wall strain analysis after myocardial infarction (MI). Compared with baseline, secant modulus changed with post-MI remodeling and was proposed as an earlier or more sensitive marker of myocardial mechanical deterioration than left ventricular ejection fraction (EF) alone. The findings support myocardial elasticity metrics from CMR as potential early detection biomarkers and mechanistic readouts for ischemic heart failure progression.
Lefkowitz E, Ref J, Bravo F et al. · Scientific reports · (2026) · View on PubMed ↗ · Free PDF ↗
Multiparametric Cardiac Magnetic Resonance Characterization of the Noninfarcted Myocardium: Definition, Assessment, and Clinical Significance.
This review studied how cardiac magnetic resonance (CMR) can characterize the noninfarcted myocardium (NIM) after acute myocardial infarction (AMI) in patients, beyond standard assessment of infarct size and peri-infarct injury. It found that CMR can detect ischemic injury–related changes in the NIM, including inflammation, interstitial expansion, and altered myocardial deformation. The scientific significance is that NIM CMR biomarkers may better explain post-AMI remodeling and risk than infarct-focused metrics alone.
Pavon AG, Bergamaschi L, Guglielmo M et al. · JACC. Cardiovascular imaging · (2026) · View on PubMed ↗
Ischemia, Microvascular Dysfunction, and Invasive Physiology (IMR/CWP/MVO)
Prognostic Implications of Coronary Microvascular Dysfunction in ST-Elevation Myocardial Infarction by Obesity Status.
This multicentre prospective cohort study evaluated coronary microvascular dysfunction (CMD) in ST-elevation myocardial infarction (STEMI) patients undergoing primary percutaneous coronary intervention (PPCI), stratifying outcomes by obesity category (BMI <24, 24–28, ≥28 kg/m2). The key finding was that CMD defined by an angiography-derived index of microcirculatory resistance (angio-IMR) >40 U carried prognostic implications that differed by obesity status. This is significant because it supports using angio-IMR to identify higher-risk STEMI patients and suggests obesity modifies the prognostic impact of microvascular dysfunction.
Guo Q, Guo Y, Shi S et al. · Diabetes, obesity & metabolism · (2026) · View on PubMed ↗
Pre-perfusion coronary wedge pressure and microvascular obstruction in anterior ST elevation myocardial infarction (STEMI): An analysis from the EUROICE study.
This EUROICE study analysis investigated the relationship between coronary wedge pressure (CWP) measured during balloon occlusion and microvascular obstruction (MVO) assessed by cardiac magnetic resonance in anterior STEMI patients undergoing primary PCI. The key finding was that pre-perfusion CWP provided clinically relevant information about microvascular injury that is not captured by post-reperfusion indices like index of microvascular resistance (IMR). This is significant because it supports earlier invasive assessment of microvascular compromise during occlusion, potentially improving risk prediction and management of STEMI patients.
Butt H, van Beek K, Sajjad U et al. · International journal of cardiology · (2026) · View on PubMed ↗
Right Heart Structure/Function and Pulmonary Vascular Disease (including diastology, RV remodeling)
Two decades of pulmonary vascular disease and ischemic heart disease mortality in the united states: A longitudinal analysis using CDC WONDER (1999-2020).
Using the CDC WONDER database, this longitudinal analysis quantified pulmonary vascular disease (PVD) and ischemic heart disease (IHD) mortality trends in U.S. adults aged ≥45 years from 1999–2020, including demographic and geographic disparities. The key finding was that combined PVD and IHD deaths increased over time, with age-adjusted mortality rates rising from 6.9 to 8.9 per 100,000 between 1999 and 2020. This is significant for public health planning because it documents long-term mortality burden and highlights populations and regions that may require targeted prevention and care strategies.
Nawaz A, Hafeezullah F, Siddiqui ZA et al. · Journal of thrombosis and thrombolysis · (2026) · View on PubMed ↗
Hemodynamic and metabolomic responses to infusion of GLP-1 agonist exenatide in pulmonary arterial hypertension.
This first-in-disease clinical study evaluated the acute hemodynamic and metabolomic effects of the GLP-1 receptor agonist exenatide given intravenously during right heart catheterization in patients with idiopathic pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH), alongside a monocrotaline (MCT) PAH rodent model. Exenatide was well tolerated and acutely reduced mean pulmonary artery pressure, with multisite blood sampling and CMR in the animal model used to characterize associated metabolic and cardiac responses. The study is significant because it provides early human mechanistic evidence that GLP-1 agonism may beneficially modulate pulmonary vascular and right-heart physiology in PAH/CTEPH.
Samaranayake CB, Niglas M, Baxan N et al. · JCI insight · (2026) · View on PubMed ↗ · Free PDF ↗
Right Heart Diastology, Where Are We Now?
This narrative review studied the current state of knowledge on right heart diastology by synthesizing invasive physiology, imaging, and human myocardial data. It reframes right heart diastolic dysfunction as a unified diastolic unit integrating right atrial function, right ventricular compliance, and pulmonary arterial load, emphasizing that relaxation/compliance abnormalities often precede overt right systolic failure. The review is significant because it provides a conceptual framework to standardize measurement and improve early detection of right heart failure risk in pulmonary vascular disease and related conditions.
Kocx CJ, Hemnes AR, Healy J et al. · Circulation research · (2026) · View on PubMed ↗ · Free PDF ↗
Metabolomics of Right Ventricular Function in Pulmonary Hypertension.
This study analyzed metabolomics data from the multicenter PVDOMICS cohort to identify metabolites and pathways associated with right ventricular (RV) systolic function across pulmonary hypertension (PH) phenotypes. Using RV systolic function metrics including fractional area change (echo), global longitudinal strain (echo), and ejection fraction (cardiac magnetic resonance), the authors found metabolite associations with RV function that varied by pulmonary vascular resistance, PH group 1 status, and sex. Scientifically, it advances understanding of RV dysfunction mechanisms in PH beyond group 1 disease and suggests sex- and phenotype-specific metabolic signatures.
Chacon-Barahona J, Chung SJ, Garry JD et al. · Circulation research · (2026) · 1 citations · View on PubMed ↗
Arteriovenous fistula creation results in cardiac dysfunction and remodeling in a uremic pig model.
This animal study investigated cardiovascular effects of arteriovenous fistula (AVF) creation in a uremic pig model of end-stage kidney disease, using chronic kidney disease induction via renal embolization followed by AVF creation supported by percutaneous transluminal angioplasty (PTA). It found that AVF creation led to cardiac dysfunction and cardiac remodeling in the uremic pigs. The scientific significance is that this large-animal model enables mechanistic study of AVF-associated cardiovascular complications relevant to hemodialysis patients.
Kane J, Singh PG, Kilari S et al. · American journal of physiology. Renal physiology · (2026) · View on PubMed ↗
Structural and Functional Abnormalities in the Preterm Heart: From Development to Adulthood.
This review examined how preterm birth affects cardiac development and leads to structural and functional abnormalities in the preterm heart from infancy through adulthood. It highlights mechanisms including abnormal oxygen exposure, disrupted cellular architecture, extracellular matrix remodeling, altered cardiomyocyte mitochondrial number/function, immature sarcoplasmic/endoplasmic reticulum, and increased surgical procedural stress exposure. The findings support the need for heightened long-term cardiovascular surveillance and mechanistically informed prevention strategies in people born preterm.
Zegelbone P, Young K, Hughes F et al. · Journal of the American Heart Association · (2026) · View on PubMed ↗ · Free PDF ↗
Congenital Heart Disease After Repair (Tetralogy of Fallot)
Smaller Right Ventricle Results in Poorer Exercise Performance in Young Patients With Repaired Tetralogy of Fallot.
The study examined young patients with surgically repaired tetralogy of Fallot (rTOF) with pulmonary insufficiency using cardiopulmonary exercise testing (CPET) and cardiac magnetic resonance (CMR), focusing on right ventricular (RV) size and exercise performance. The key finding was that a smaller right ventricle was associated with poorer exercise performance, with oxygen pulse (V̇O2/heart rate) used as a surrogate for stroke volume and related to CMR measures. This is significant because it refines the understanding of RV remodeling and functional capacity in rTOF, informing risk stratification and potential timing of pulmonary valve replacement.
Mhanna C, Kourpas K, Tsuda T · Circulation journal : official journal of the Japanese Circulation Society · (2026) · View on PubMed ↗ · Free PDF ↗
The relationship between myocardial and hepatic T1 relaxometry on cardiovascular magnetic resonance imaging and clinical outcomes late after tetralogy of Fallot repair.
This prospective CMR study enrolled adults after repaired tetralogy of Fallot (rTOF) and healthy controls to assess whether myocardial and hepatic native T1 relaxometry and derived extracellular volume fraction (ECV) relate to residual hemodynamic load and late clinical outcomes. Myocardial and hepatic parametric imaging measures showed associations with post-rTOF clinical status and provided prognostic value for outcomes in the rTOF population stratified by residual pulmonary stenosis and/or pulmonary regurgitation. These findings support using combined myocardial–hepatic CMR T1/ECV biomarkers to better characterize diffuse fibrosis burden and risk after rTOF repair.
Ishikita A, Marques L, Thomas S et al. · Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · (2026) · View on PubMed ↗ · Free PDF ↗
Cardiomyopathy Genetics, Inherited Disease, and Dystrophinopathy
Filamin C Genetic Cardiomyopathy Presenting as Acute Myocardial Injury.
This JACC Case Reports report described a 46-year-old man with acute myocardial injury characterized by nonischemic imaging, in whom cardiac magnetic resonance showed extensive ring-like subepicardial late gadolinium enhancement without myocardial edema. The key finding was that genetic testing identified a pathogenic FLNC (filamin C) variant, with follow-up showing persistent fibrosis and preserved ventricular function without arrhythmias. This is significant because it links a distinctive CMR pattern to FLNC genetic cardiomyopathy, improving diagnostic accuracy in patients presenting with acute myocardial injury.
Alexandrino FB, Curtis B, Nguyen C et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗
Epicardial adipose tissue is associated with impaired outcomes in genotype-positive hypertrophic cardiomyopathy.
This retrospective study quantified epicardial adipose tissue (EAT) by cardiovascular magnetic resonance in genotype-positive hypertrophic cardiomyopathy (HCM) patients to test whether EAT volume predicts malignant ventricular arrhythmias (MVA) and heart failure (HF). Patients with higher EAT volume (split by median) had worse outcomes, with multivariable Cox regression showing an association between greater EAT and increased risk of MVA and/or HF events. The findings suggest that EAT burden is a clinically relevant prognostic marker in genotype-positive HCM and could refine risk assessment for arrhythmia and HF.
Mahmoud B, Koppelaar AJ, Michels M et al. · European journal of heart failure · (2026) · View on PubMed ↗ · Free PDF ↗
Discordant Cardiomyopathy Phenotypes in Siblings With Homozygous FKRP c.1100T>C.
This JACC Case Reports report describes two South African Afrikaner siblings with homozygous FKRP c.1100T>C (p.Ile367Thr) who had discordant cardiomyopathy phenotypes. The older brother developed progressive non-dilated-to-dilated cardiomyopathy with extensive late gadolinium enhancement fibrosis on cardiac MRI over years despite partial reverse remodeling, illustrating marked intrafamilial variability. Clinically, the case highlights that even with the same FKRP genotype, cardiac involvement in limb-girdle muscular dystrophy R9 can be heterogeneous, supporting individualized cardiac surveillance and risk assessment.
Mahon N, Coad S, Kiamanesh O · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗
Natural history of cardiac involvement in women carrying pathogenic DMD gene variants: a 7-year longitudinal study.
This prospective 7-year longitudinal study followed 34 women carrying pathogenic dystrophin (DMD) gene variants (19 predicted Duchenne muscular dystrophy and 15 Becker muscular dystrophy) to characterize natural history of cardiac involvement. Using cardiac magnetic resonance with late gadolinium enhancement (LGE) and other assessments, it tracked changes in ventricular function, myocardial fibrosis, and conduction/arrhythmia evolution over time. Clinically, the findings support CMR-based surveillance strategies for early detection and monitoring of cardiomyopathy progression in female DMD variant carriers.
Lyu Z, Joensen H, Poulsen NS et al. · Journal of neurology · (2026) · View on PubMed ↗ · Free PDF ↗
Cardiac MRI in cardiac dystrophinopathy: recommendations on imaging.
This article provides expert recommendations on cardiac MRI (CMR) for cardiac dystrophinopathy, focusing on patients with Duchenne muscular dystrophy (DMD) and the progressive development of cardiac pumping weakness. It emphasizes that CMR can detect tissue changes earlier than echocardiography and maintains measurement accuracy across disease progression, supporting regular imaging for treatment response monitoring. The clinical significance is standardizing how CMR is used to guide cardioprotective therapy decisions in DMD.
McDiarmid A, Augustine D, Coats C et al. · Open heart · (2026) · View on PubMed ↗ · Free PDF ↗
Epidemiology of non-ischaemic dilated cardiomyopathy.
This narrative review summarized the epidemiology of non-ischaemic dilated cardiomyopathy (DCM), defined by left ventricular dilatation and systolic dysfunction, with emphasis on prevalence and sex differences across young and middle-aged adults. It reports that non-ischaemic DCM is more common than previously thought, with prevalence around 1 in 220 based on cardiac magnetic resonance imaging studies and about twice the prevalence in men than women, potentially higher when early/subclinical disease is included. The review highlights how advances in genetic technologies have improved understanding of the genetic basis of non-ischaemic DCM and informs future risk assessment and screening.
Ramos-López N, Domínguez F, Ochoa JP et al. · Nature reviews. Cardiology · (2026) · View on PubMed ↗
Valvular Heart Disease and Aortopathy Outcomes (AS/AR/HTN)
Coronary artery Ectatic/Aneurysmatic disease: From pathophysiology to management.
This review article synthesized current knowledge on coronary artery ectatic/aneurysmatic disease (CAE/CAA), focusing on mechanisms and management across adult and pediatric etiologies. The key finding was that CAE/CAA has multifactorial pathophysiology (including atherosclerosis, genetic predisposition, systemic autoimmunity, and infectious triggers) and is associated with thrombosis, embolization, and acute coronary syndromes even without obstructive coronary disease. This is significant because it consolidates diagnostic and therapeutic considerations for a rare but high-risk condition and clarifies how underlying causes differ by age group.
Markousis-Mavrogenis G, Ebrahimihoor E, Lima JAC et al. · Progress in cardiovascular diseases · (2026) · View on PubMed ↗
Trends and Projections for Aortic Stenosis and Hypertension-Related Mortality Among Older Adults in the United States: A Retrospective Population-Based Analysis.
This retrospective population-based analysis studied trends and projections of mortality related to aortic stenosis (AS) and hypertension (HTN) among older adults in the United States from 1999–2020 using CDC WONDER Multiple Cause of Death data. It found measurable mortality trends over time and used joinpoint regression plus ARIMA modeling to project future mortality patterns to 2030, including assessment of demographic-geographic disparities. The clinical significance is improved understanding of how combined AS and HTN burden affects future mortality risk, informing public health planning and risk stratification.
Bhatti MI, Safiullah M, Farhan K et al. · High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · (2026) · View on PubMed ↗
Contemporary Overview of Aortic Regurgitation in Young Individuals: Insights From Real-Life Evidence.
This review studied the real-world epidemiology, diagnosis, and management of aortic regurgitation (AR) in young adults aged 18–44 years. It reports that AR in this age group is frequently under- or misdiagnosed and that prognosis depends on regurgitation severity, underlying cause, early left ventricular dysfunction, and the intervention strategy, with ongoing uncertainty about optimal timing for surgery in asymptomatic chronic AR. The article emphasizes prompt echocardiographic assessment and emerging multimodality/left-ventricular threshold approaches to better guide intervention timing.
Sozzi FB, Gamberini G, Kim JK et al. · Journal of the American Heart Association · (2026) · View on PubMed ↗ · Free PDF ↗
Cardiac Masses, Tumors, and Metastases (multimodality imaging)
Catheter ablation of epicardial premature ventricular complexes in patients with and without cardiac scar.
In a retrospective cohort, the study assessed catheter ablation outcomes for epicardial premature ventricular complexes (PVCs) in patients with and without cardiac scar, using late gadolinium enhanced cardiac magnetic resonance (LGE-CMR) to define scar presence. The key finding was that procedural outcomes differed according to whether cardiac scar was present among patients undergoing epicardial PVC ablation. This is significant because it helps clinicians anticipate ablation success and tailor procedural planning based on substrate (scar) rather than assuming idiopathic epicardial origin alone.
Jiwani S, Arps K, Shah M et al. · Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · (2026) · View on PubMed ↗ · Free PDF ↗
Left Ventricular Metastasis from Hepatocellular Carcinoma Presenting With Systemic Embolization and Stroke.
This case report studied left ventricular (LV) metastasis from hepatocellular carcinoma (HCC) in a 71-year-old man presenting with acute ischemic stroke and systemic embolization. Transthoracic echocardiography and cardiac magnetic resonance imaging (CMR) identified an LV mass consistent with metastatic disease rather than thrombus, explaining multifocal infarcts and other embolic findings. Clinically, it highlights that CMR and multimodality imaging should be considered when HCC patients present with stroke and suspected cardiac embolic sources, even when the metastasis is in the left ventricle.
Rashwan R, Kholeif Z, Vega-Sanabria B et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗
New-Onset Atrial Flutter Revealing a Large Right Coronary Artery to Superior Vena Cava Fistula.
This JACC Case Reports report studied a 63-year-old man whose new-onset atrial flutter revealed a large right coronary artery to superior vena cava (RCA–SVC) fistula. Multimodality imaging with coronary computed tomography angiography, cardiac magnetic resonance, and cardiac catheterization confirmed the fistula and associated right-sided chamber dilation, and the patient underwent successful transcatheter coil embolization. Clinically, it underscores that coronary fistulas can present with arrhythmias and hemodynamic instability, and that multimodality imaging plus catheter-based closure can be curative.
Acharya S, Patel V, Shahane S et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗
Giant Cardiac Glomangioma With Extensive Intravascular Extension: A Surgical and Pathological Rarity.
This case report studied a patient with a giant cardiac glomangioma showing extensive intravascular extension from the right ventricular free wall into the right atrium and inferior vena cava, reaching the left common iliac vein. The tumor was successfully treated with surgical excision, with excellent clinical outcome reported, and the rarity was emphasized by the unusual extent of vascular involvement. Scientifically and clinically, it highlights the need for careful multimodality imaging and surgical planning for rare glomus-body tumors with major intravascular spread.
Bhutta M, Tariq K, Iqtadar R et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗
Diagnostic Accuracy of an Integrated Multimodality Imaging Approach in Patients With Cardiac Masses.
In a prospective histology-referenced diagnostic study, investigators evaluated suspected cardiac masses using integrated multiparametric scoring from echocardiography, cardiac MRI (CMR), cardiac CT (CCT), and 18F-fluorodeoxyglucose (18F-FDG) PET, comparing single-modality versus combined performance for malignancy identification. The integrated multimodality approach improved diagnostic accuracy over individual imaging tests for distinguishing malignant cardiac masses. This supports a multimodal imaging workflow that leverages CMR, CCT, and FDG PET together to improve preoperative characterization of cardiac tumors.
Angeli F, Armillotta M, Foà A et al. · JACC. Cardiovascular imaging · (2026) · View on PubMed ↗ · Free PDF ↗
Rare presentation of right ventricular myxoma causing severe anaemia and acute kidney injury.
This BMJ Case Reports article describes a 53-year-old man with a rare right ventricular myxoma presenting with severe anemia and acute kidney injury. The diagnostic workup used transthoracic and transesophageal echocardiography, CT with FDG PET, cardiac MRI, and endomyocardial biopsy, and the patient was treated with surgical excision and tricuspid valve repair. The case underscores the need for a comprehensive multimodality evaluation of intracardiac masses when systemic complications occur.
Shah S, Gill JS, Gill J et al. · BMJ case reports · (2026) · View on PubMed ↗
Imaging of Myocardial Carcinoid Metastasis.
This case series studied multimodality imaging for myocardial metastasis from neuroendocrine tumors (NETs) in 2 patients with isolated cardiac metastases without valvular involvement. It found that Gallium-68 DOTATATE PET/CT identified the cardiac metastases and cardiac MRI further characterized them, whereas transthoracic echocardiography had limited ability to detect myocardial involvement. The clinical significance is that PET/CT and CMR can improve detection and characterization of cardiac NET metastases when echocardiography is insensitive.
Ranganath S, Ynalvez L, Ryoo Ali HJ et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗
Cardiac tumour in paediatrics: the role of multimodal imaging and therapeutic catheterisation.
This case report studied the diagnostic role of multimodal imaging and therapeutic catheterization in a 14-year-old male with a cardiac mass initially misdiagnosed as asymmetric septal hypertrophic cardiomyopathy. It found that echocardiography identified a highly vascular interventricular septal mass with a severe right ventricular outflow tract gradient (112 mmHg), and cardiac MRI confirmed a highly vascular lesion with high signal on HASTE, T1, and T2 sequences and a markedly elevated extracellular volume (67%). The clinical significance is that multimodal imaging can refine tumor diagnosis and guide appropriate interventional management in pediatric cardiac masses.
Trujeque L, Hernandez K, Tavera A · Cardiology in the young · (2026) · View on PubMed ↗ · Free PDF ↗
Superior anti-DLBCL efficacy of novel organic arsenical Z2-A-Z2 through ROS-mediated apoptosis and critical NF-κB/IκBα signaling pathway inhibition.
This preclinical cancer study evaluated the novel organic arsenical Z2-A-Z2 in diffuse large B-cell lymphoma (DLBCL), focusing on its ability to overcome therapy resistance driven by aberrant NF-κB signaling. Z2-A-Z2 induced ROS-mediated apoptosis and inhibited the NF-κB/IκBα signaling pathway more effectively than prior approaches, with effects assessed in GCB- and ABC-subtype DLBCL cell lines using CCK-8 viability assays and flow cytometry plus Western blotting for mechanistic readouts. The findings suggest Z2-A-Z2 as a promising NF-κB–targeting therapeutic candidate for DLBCL subtypes with survival-pathway activation.
Wei W, Ma Y, Liu Y et al. · Journal of experimental & clinical cancer research : CR · (2026) · View on PubMed ↗ · Free PDF ↗
Generated automatically on May 25, 2026. Covers PubMed articles published May 18, 2026 – May 25, 2026. Summaries are AI-generated; always consult the original publication for clinical or research decisions.