What’s New in Cardiac MRI?

June 01, 2026 · 94 articles · 15 research themes · covering May 25, 2026 – June 01, 2026

Overview

Across this week’s set of papers, a clear dominant theme is the rapid expansion of cardiac MRI as a quantitative, prognostic platform—powered by new acquisition/reconstruction strategies (e.g., accelerated cine, free-breathing LGE, motion correction, mid-field wide-bore CMR) and by AI/deep learning methods that extract more information from baseline scans. Multiple studies show that “better measurements” (quantitative CMR regurgitation, atrial–ventricular coupling, pulmonary transit time, strain, T1/ECV, and stress phenotyping) can outperform conventional categorical grading or single-parameter approaches for risk prediction in diverse conditions, from HFpEF and STEMI to dilated cardiomyopathy, myocarditis-spectrum disease, and pulmonary hypertension.

A second major theme is mechanistic phenotyping of myocardial disease using tissue characterization and inflammation markers. Several studies focus on myocarditis and cardiac inflammation—using CMR edema/edema interpretation frameworks, PET/CMR combinations, atrial functional metrics, and sarcoidosis inflammation mapping—to move beyond diagnosis alone toward prognosis and monitoring. Related work also highlights how systemic or immune/inflammatory pathways can translate into cardiac remodeling (e.g., epilepsy-linked CXCL1/CXCL9 signaling, IL-6R blockade effects on platelet/thrombus biomarkers, and immune checkpoint inhibitor myocarditis/vasospasm mimicking acute coronary syndromes).

Finally, the digest underscores a growing convergence of cardiology with oncology and immunotherapy, where imaging and biomarkers are used both to anticipate treatment-related toxicity and to guide complex clinical decisions. Baseline CMR plus AI improves prediction of cancer therapy–related cardiac dysfunction, while reviews and case-based reports emphasize standardized surveillance frameworks and the need for prompt recognition of overlapping immune-mediated cardiac syndromes. Together, these studies point toward a future of more personalized, imaging-driven cardiovascular care—where quantitative CMR, multimodal data, and mechanistic biomarkers jointly inform risk, monitoring, and therapy selection.

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Cardiac MRI/CT AI & Radiomics for Diagnosis/Prediction

Integrative omics analysis incorporating cardiovascular magnetic resonance imaging pinpoints potentially druggable plasma proteins for cardiovascular diseases.

This integrative omics study combined cardiovascular MRI (CMR) traits with proteomics genetics to identify potentially druggable plasma proteins for cardiovascular diseases using protein quantitative trait loci (pQTL) and genome-wide association study (GWAS) data. The key finding was that a sequential pipeline (including proteome-wide association study, Mendelian randomization, and related integrative steps) pinpointed plasma proteins whose genetic determinants align with CMR phenotypes and multiple CVD outcomes. The significance is that CMR-informed genetic/proteomic integration can prioritize actionable therapeutic targets beyond traditional risk factors.

Gong W, Guo P, Liu L et al. · Life metabolism · (2026) · View on PubMed ↗ · Free PDF ↗

Non-contrast multimodal cardiac MRI for predicting coronary microvascular dysfunction in patients with hypertrophic cardiomyopathy.

This study developed and tested a non-contrast multimodal cardiac MRI radiomics model to predict coronary microvascular dysfunction (CMD) in 290 patients with hypertrophic cardiomyopathy (HCM). Using logistic regression on radiomics features extracted from end-diastolic four-chamber and end-diastolic short-axis views, the model was designed to identify CMD without relying on contrast-enhanced CMR. A reliable non-contrast approach could broaden access and reduce risk/cost associated with contrast agents for CMD detection in HCM.

Li J, Zhu L, Liu Y et al. · Magnetic resonance imaging · (2026) · View on PubMed ↗

Automated assessment of right heart function by artificial intelligence: A systematic review and meta-analysis.

This systematic review and meta-analysis evaluated the diagnostic accuracy of artificial intelligence (AI) models for assessing right ventricular (RV) size and function using imaging data. The key finding was that the pooled evidence synthesized performance metrics for AI-based RV assessment and assessed overall evidence quality, addressing uncertainty in diagnostic accuracy. This is significant because it informs whether AI can reliably replace or augment echocardiography for RV evaluation in clinical practice.

Eini P, Serpoush H, Rezayee M et al. · European journal of radiology open · (2026) · 2 citations · View on PubMed ↗ · Free PDF ↗

A composable multimodal framework for cine CMR-text-driven prediction of heart failure outcomes.

This study proposed and evaluated a composable multimodal framework for predicting heart failure outcomes using cine CMR text-driven features combined with other modalities. The key finding was that the multimodal, composable approach improved outcome prediction performance compared with more limited single-source or less integrated modeling strategies. This advances the use of cine CMR-derived information (including text-driven representations) for more holistic, data-driven heart failure risk assessment.

Chen J, Sun J, Wang X et al. · Physiological measurement · (2026) · View on PubMed ↗ · Free PDF ↗

AI in the EP Lab - Mapping, Imaging, and Signal Interpretation.

This review article studied how artificial intelligence (AI) can be applied in electrophysiology (EP) laboratories for mapping, imaging, and signal interpretation in arrhythmia diagnosis and treatment. It found that AI can integrate multimodal electrical/anatomical/imaging data to reduce inter-observer variability, improve identification of arrhythmogenic substrate, and support procedural decision-making, including the concept of patient-specific “cardiac digital twins.” The work is significant because it frames AI-driven, mechanistic personalization as a pathway to better risk prediction and more precise EP interventions.

Anand AB, Rajawat K · Indian pacing and electrophysiology journal · (2026) · View on PubMed ↗ · Free PDF ↗

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Cardiac MRI Quantification & Image Reconstruction Methods

Incorporating modality-specific intensity prior as text prompt for multimodal myocardial pathology segmentation.

This methodological paper developed an intensity-guided multimodal myocardial pathology segmentation framework (I-MMSeg) that uses multimodal large language models (e.g., GPT-4o) to generate modality-specific intensity priors for CMR segmentation. The key finding is that incorporating these text prompts improves segmentation performance by encoding relative intensity ordering and boundary intensity characteristics across modalities. Scientifically, it advances multimodal CMR pathology segmentation by leveraging foundation-model-derived priors rather than relying only on geometric or morphological constraints.

Fang D, Gu Y, Yu L et al. · Medical image analysis · (2026) · View on PubMed ↗

Grayscale-inverted bright-blood late gadolinium enhancement improves reader confidence in ischemic scar detection: a multivendor study.

This multivendor CMR study evaluated whether grayscale-inverted bright-blood late gadolinium enhancement (LGE) improves reader confidence and diagnostic accuracy for ischemic scar detection compared with standard bright-blood LGE. In 120 patients scanned on GE, Philips, and Siemens 1.5T systems, grayscale inversion enhanced visual contrast for subendocardial infarcts and improved reader confidence, with effects assessed across reader experience and vendor. The technique is a simple, vendor-independent post-processing approach that could reduce missed ischemic scar detection in routine clinical CMR.

Károlyi M, Groenhoff L, Spiczak JV et al. · European journal of radiology · (2026) · View on PubMed ↗ · Free PDF ↗

Accelerated reconstruction of 5D free-running MRI with variable projection-augmented Lagrangian (VPAL).

This study developed an accelerated reconstruction method for ferumoxytol-enhanced 5D free-running whole-heart cardiac MRI using variable projection-augmented Lagrangian (VPAL) instead of the alternating direction method of multipliers (ADMM). VPAL was compared against ADMM for computational time and image quality to enable more practical in-line 5D CMR reconstruction. Faster, clinically feasible reconstruction could improve routine use of high-quality 5D CMR for vascular/whole-heart assessment.

Yang Y, Naeem M, van Assen M et al. · Magnetic resonance imaging · (2026) · View on PubMed ↗ · Free PDF ↗

Simultaneous Multi-Slice Acceleration for Free-Breathing Motion Corrected Late Gadolinium Enhancement Imaging.

This study developed and evaluated accelerated free-breathing motion-corrected and averaged late gadolinium enhancement (LGE) MRI protocols using simultaneous multi-slice (SMS) bSSFP with GC-LOLA correction and phase-sensitive inversion recovery (PSIR) reconstruction. In 26 clinical cardiac MRI patients, two protocols were compared—SMS-accelerated versus a non-SMS reference—assessing myocardial sharpness, scar-to-blood and scar-to-healthy myocardium contrast-to-noise estimates, blood-to-healthy myocardium CNRe, and scar volume. If SMS acceleration preserves LGE image quality under free breathing, it could improve feasibility and throughput of scar imaging in routine clinical practice.

Kowalik GT, Kunze KP, Bosio F et al. · Magnetic resonance in medicine · (2026) · View on PubMed ↗ · Free PDF ↗

K-CC-MoCo: A Fast k-Space-Based Respiratory Motion Correction for Highly Accelerated First-Pass Perfusion Cardiovascular MR.

This study proposed K-CC-MoCo, a k-space–based inter-frame rigid respiratory motion correction method for highly accelerated first-pass perfusion cardiovascular MRI (FPP-CMR). By estimating and correcting respiratory motion directly in k-space, the approach avoids the need for an initial image-domain reconstruction that can limit compatibility with model-based or deep learning reconstructions. Enabling robust motion correction during accelerated FPP-CMR could improve noninvasive assessment of coronary microcirculation and coronary artery disease.

Moya-Sáez E, Menchón-Lara RM, Sánchez-González J et al. · Magnetic resonance in medicine · (2026) · View on PubMed ↗ · Free PDF ↗

Rosette Cardiac MR Fingerprinting for Simultaneous T1, T2, T 2 * , and Fat Fraction Mapping Using a Multi-Echo Deep Image Prior Reconstruction.

The study developed a rosette cardiac MR fingerprinting (cMRF) method using a multi-echo acquisition and a deep image prior reconstruction to simultaneously map myocardial T1, T2, T2*, and fat fraction in cardiac MRI. The key finding was that the deep image prior–based reconstruction enabled simultaneous multi-parameter quantitative mapping from a single ECG-gated, single-breathhold rosette trajectory scan. This is clinically significant because it could streamline CMR assessment of myocardial tissue pathology by reducing scan time while improving quantitative characterization of T1/T2/T2* and fat content.

Cummings E, Cruz G, Richardson J et al. · Magnetic resonance in medicine · (2026) · View on PubMed ↗ · Free PDF ↗

MoCo + ROVir: Synergy Between Respiratory Motion Compensation and Cardiac Receive Region Focusing for Cardiac MRI.

The study evaluated a combined reconstruction strategy—MoCo (rigid respiratory motion compensation) plus ROVir (region-optimized virtual coils) integrated into cardiac/respiratory-resolved low-rank tensor (LRT) reconstruction—for cardiac MRI in pediatric patients. The key finding was that MoCo+ROVir-LRT improved the representation of cardiac motion relative to respiratory motion compared with LRT, MoCo-LRT, and ROVir-LRT baselines. This is significant because it may reduce motion-related artifacts and improve image quality for simultaneous cardiac- and respiratory-resolved cardiac MRI.

Hu Z, Lee HL, Cao T et al. · Magnetic resonance in medicine · (2026) · View on PubMed ↗ · Free PDF ↗

Clinical evaluation of accelerated breath-held and free-breathing cine cardiac MRI using model-based deep learning reconstruction (SonicDL) in children and young adults.

This clinical imaging evaluation studied model-based deep learning reconstruction (SonicDL) for accelerated cine cardiac MRI in children and young adults, comparing accelerated breath-held and free-breathing bSSFP cine acquisitions across multiple acceleration levels. The key finding was that SonicDL reduced scan time and maintained diagnostic image quality and ventricular volumetric accuracy compared with conventional cine imaging. This supports broader pediatric/young-adult use of faster, more tolerable cine CMR protocols that reduce breath-hold burden.

Kocaoglu M, Ta H, Lang SM et al. · Pediatric radiology · (2026) · View on PubMed ↗

Mid-Field Cardiovascular MRI in Class III Obesity.

This JACC Case Reports series studied the feasibility of mid-field cardiovascular MRI in five patients with class III obesity (BMI ≥40 kg/m2) using a 0.55-T wide-bore (80-cm) prototype scanner. Clinically adequate image quality was achieved for cine, parametric mapping, phase-contrast flow, late gadolinium enhancement, and thoracic MR angiography, enabling comprehensive cardiac assessment despite conventional bore/table limitations. The report suggests mid-field wide-bore CMR can expand access to CMR-based diagnosis and tissue characterization in severe obesity.

Gil KE, Binzel K, Goyal A et al. · JACC. Case reports · (2026) · 1 citations · View on PubMed ↗ · Free PDF ↗

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CMR Biomarkers of Myocardial Inflammation & Edema

Cardiac MRI in Depiction of Myocardial Edema: A Comprehensive Review.

This comprehensive review studied the pathophysiology of myocardial edema and how it is detected and differentiated using cardiac MRI across cardiovascular diseases affecting fluid homeostasis. It found that myocardial edema is a multifactorial marker (ischemic, inflammatory, infiltrative, toxic, infectious, autoimmune) whose clinical interpretation depends on imaging strategies, artifacts, and differential diagnoses for risk stratification. Clinically, the review emphasizes that standardized understanding of CMR edema findings can improve diagnosis and prognostic assessment across multiple cardiac conditions.

Onder O, Kosanovich C, Kirshenboim ZE et al. · Radiographics : a review publication of the Radiological Society of North America, Inc · (2026) · View on PubMed ↗

Diagnostic and prognostic value of T2 mapping in cardiac sarcoidosis.

This study evaluated whether 3T cardiac magnetic resonance (CMR) T2 mapping can diagnose and prognosticate cardiac sarcoidosis in 39 patients who also underwent 18F-FDG PET. T2 mapping showed diagnostic and prognostic utility for myocardial inflammation/future outcomes, potentially reducing reliance on the radiation- and logistics-burden of serial 18F-FDG PET. If validated, CMR T2 mapping could become a practical, non-radiation tool for routine monitoring of active inflammation and risk stratification in cardiac sarcoidosis.

Uno M, Kosuge H, Kobayashi M et al. · International journal of cardiology. Heart & vasculature · (2026) · View on PubMed ↗ · Free PDF ↗

18F-fluorodeoxyglucose positron emission tomography and rest myocardial perfusion imaging in non-granulomatous myocarditis.

This multicenter prospective feasibility study evaluated combined 18F-fluorodeoxyglucose (FDG) PET/CT with rest myocardial perfusion imaging (rMPI) for diagnosing non-granulomatous myocarditis in patients undergoing both PET/CT and CMR, with endomyocardial biopsy (EMB) or adjudicated clinical diagnosis as the reference standard. The combined imaging approach demonstrated diagnostic performance for myocarditis that was compared against CMR and reference standards. If validated, FDG-PET plus rMPI could improve noninvasive diagnosis of myocarditis where EMB is unavailable or limited.

Lucinian YA, Martineau P, Harel F et al. · European journal of nuclear medicine and molecular imaging · (2026) · View on PubMed ↗

Atrial Function by Long Axis Shortening Enhances Risk Stratification Beyond Traditional CMR Markers in Possible Myocarditis.

This study evaluated whether left atrial (LA) and right atrial (RA) long axis shortening (LAS) measured by cardiac MRI improves risk stratification beyond traditional CMR markers in patients with possible myocarditis. In patients meeting 2025 ESC criteria for possible myocarditis undergoing CMR at two tertiary centers, atrial functional impairment by LAS was associated with major cardiovascular adverse events (MACE) and provided incremental prognostic value beyond LVEF and late gadolinium enhancement (LGE). These findings suggest atrial functional metrics on CMR may refine prognosis in myocarditis-spectrum disease.

Ciocca N, Brändle D, Riederer L et al. · JACC. Cardiovascular imaging · (2026) · View on PubMed ↗ · Free PDF ↗

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CMR Tissue Characterization (Fibrosis, Scar, Amyloid, Tumor) & Pathology

Multi-organ infarctions secondary to a cardiac papillary fibroelastoma in early childhood.

This case report studied a 4-year-old girl presenting with acute stroke and renal infarction in whom a cardiac tumor was identified. Echocardiography suggested a mass and cardiac MRI confirmed cardiac papillary fibroelastoma (CPFE), and surgical resection with histopathology established the diagnosis. The report is significant because it underscores that CPFE, though rare in early childhood, should be considered in pediatric embolic stroke when a cardiac mass is present.

Alfares F, Alghamdi M, Alkanhal A et al. · Indian journal of thoracic and cardiovascular surgery · (2026) · View on PubMed ↗ · Free PDF ↗

One-year worsening heart failure and myocardial T1 mapping in patients with wild-type transthyretin amyloid cardiomyopathy undergoing tafamidis treatment.

This retrospective clinical study evaluated one-year changes in myocardial T1 mapping (native T1 and extracellular volume fraction, ECV) in 60 wild-type transthyretin amyloid cardiomyopathy (ATTR-CM) patients treated with tafamidis. The key finding was that myocardial T1 mapping metrics measured by CMR were informative for short-term treatment responsiveness and were associated with the one-year composite outcome of worsening heart failure (WHF) and related events. Clinically, it supports CMR T1/ECV as a quantitative imaging biomarker to monitor tafamidis effect in wild-type ATTR-CM.

Kitagawa T, Hamamoto K, Okamoto D et al. · International journal of cardiology. Heart & vasculature · (2026) · View on PubMed ↗ · Free PDF ↗

Low-dose ventricular radiotherapy in wild-type transthyretin cardiac amyloidosis: a prospective, first-in-human, exploratory clinical trial.

This prospective first-in-human exploratory trial studied low-dose ventricular radiotherapy (10 Gy in 5 daily fractions) in patients with wild-type transthyretin cardiac amyloidosis (ATTRwt-CA). The intervention was assessed using 18F-flutemetamol amyloid PET (septal and lateral LV tissue-to-background ratio) and CMR (extracellular volume and T1 mapping) at baseline and 12 weeks. If signals of reduced amyloid burden and improved imaging biomarkers are confirmed, LD-RT could represent a novel, targeted anti-amyloid strategy for ATTRwt-CA.

Guijarro D, Massie E, Zilli T et al. · International journal of cardiology. Heart & vasculature · (2026) · View on PubMed ↗ · Free PDF ↗

An indolent course of undifferentiated pleomorphic cardiac sarcoma mimicking myxoma: A case report.

This radiology case report studied a 71-year-old woman whose cardiac undifferentiated pleomorphic sarcoma (UPS) mimicked a myxoma, with diagnosis guided by serial cardiac MRI and subsequent surgical pathology. Initial MRI showed only subtle atrial septal thickening that was interpreted as nonspecific, but follow-up imaging over 2 years demonstrated progressive growth consistent with myxoma before resection revealed high-grade UPS by histopathology and immunohistochemistry. The case emphasizes the diagnostic challenge of rare malignant cardiac tumors and the value of longitudinal imaging when findings evolve despite initial benign interpretation.

Ziaei H, Palmquist E, Fagman H et al. · Radiology case reports · (2026) · View on PubMed ↗ · Free PDF ↗

Microstructural disease and hypoperfusion in dilated cardiomyopathy underpin midwall septal fibrosis.

This prospective, multi-referral, single-center CMR study compared dilated cardiomyopathy (DCM) patients with midwall septal fibrosis (MSF+) versus those without (MSF-) and included matched controls to test whether MSF reflects distinct microstructural and microvascular abnormalities. The key finding was that MSF in DCM is underpinned by microstructural disease and myocardial hypoperfusion patterns detectable with advanced CMR. Clinically, linking MSF to specific pathophysiology strengthens risk interpretation and may guide future therapies aimed at microvascular dysfunction in DCM.

Chan FT, Coveney S, Zheng SL et al. · Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · (2026) · View on PubMed ↗ · Free PDF ↗

Multimodality Cardiac Imaging and Multidisciplinary Collaboration in Monitoring Intracardiac Sarcoma Response to Immunotherapy.

This JACC Case Reports report described multimodality cardiac imaging and multidisciplinary monitoring of intracardiac sarcoma response to immunotherapy in a 40-year-old man with metastatic alveolar soft part sarcoma causing right ventricular outflow tract obstruction. Cardiac MRI tissue characterization enabled a noninvasive diagnosis without endomyocardial biopsy, and immune checkpoint inhibitor (ICI) therapy was administered with continuous cardiology monitoring to manage concern for immune-mediated pseudoprogression. The case illustrates an imaging-driven strategy for safely tracking rare intracardiac tumor responses during ICI treatment.

Kocx C, Geraghty L, Rolfe Z et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗

Coronary-Sparing Resection of a Pediatric Left Ventricular Fibroma Involving the Left Circumflex Artery: Six-Year Follow-Up.

This case report with six-year follow-up described surgical management of a 3-month-old female with a left ventricular fibroma involving the left circumflex coronary artery, where multimodality imaging (including cardiac MRI and coronary angiography) guided planning. The key finding was that coronary-sparing partial tumor resection with mitral valvuloplasty preserved the intratumoral left circumflex artery with sustained long-term follow-up. The report highlights a feasible strategy for managing pediatric LV fibromas when critical coronary anatomy is traversed by the tumor.

Lopes MS, Amaral ME, Francisco A et al. · World journal for pediatric & congenital heart surgery · (2026) · View on PubMed ↗

The Diagnostic and Prognostic Value of Multi-Chamber Strain Analysis by Cardiac MRI in Amyloidosis.

This retrospective study assessed diagnostic and prognostic performance of multi-chamber myocardial strain measured by cardiac MRI in 47 patients with cardiac amyloidosis, relating strain to native T1 mapping and Query Amyloid Late Enhancement (QALE) and late gadolinium enhancement (LGE). Strain parameters across ventricles and atria correlated with amyloid imaging metrics and improved risk prediction for major adverse cardiovascular events (MACE) beyond conventional imaging markers. The results suggest that atrial and ventricular strain on CMR could enhance amyloidosis phenotyping and prognostication.

Chilkuri SK, Dsouza R, Houbois C et al. · Journal of thoracic imaging · (2026) · View on PubMed ↗

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Cardiovascular Risk Stratification & Prognostic Modeling (Non-oncology)

Multi-biomarker approach for predicting cardiac magnetic resonance parameters at 30 days after ST-segment elevation myocardial infarction.

This pre-specified CLEVER-ACS substudy studied whether baseline biomarkers—high-sensitivity troponin T (hsTnT), NT-proBNP, CCN1, and PCSK9—predict cardiac MRI infarct characteristics at 30 days after STEMI. The key finding was that specific baseline biomarker levels were associated with 30-day CMR-derived infarct parameters, reflecting the intermediate post-infarction phase between acute injury and chronic remodeling. Clinically, it suggests a multi-biomarker strategy to anticipate subacute infarct evolution and potentially guide risk stratification after STEMI.

Horbach T, Wenzl FA, Manka R et al. · International journal of cardiology. Heart & vasculature · (2026) · View on PubMed ↗ · Free PDF ↗

Incremental prognostic value of left atrial strain for heart failure-related events following ST-Segment elevation myocardial infarction.

This study assessed whether left atrial (LA) strain measured by cardiac MRI adds prognostic value for heart failure (HF)-related events after ST-segment elevation myocardial infarction (STEMI) across different left ventricular ejection fraction (LVEF) strata. LA strain provided incremental risk stratification for subsequent HF-related events beyond discharge LVEF. Clinically, LA strain could improve post-STEMI risk prediction and identify patients with “apparently preserved” discharge function who remain at high risk for HF.

Zhao Y, Chen XY, Zhu GJ et al. · European journal of radiology · (2026) · View on PubMed ↗

SGLT2 inhibitors therapy in patients with acute Takotsubo syndrome.

This study evaluated safety, tolerability, myocardial recovery, and inflammation effects of SGLT2 inhibitors (dapagliflozin or empagliflozin) in 22 patients with acute Takotsubo syndrome (TTS) compared with 44 propensity-score–matched untreated patients. Patients receiving SGLT2 inhibitors underwent cardiac magnetic resonance (CMR) with T2 mapping within 7 days, and the trial aimed to determine whether SGLT2 therapy improves CMR markers of recovery and inflammation versus no SGLT2 treatment. If beneficial, SGLT2 inhibitors could represent a new adjunct therapy to enhance myocardial healing in acute TTS, a condition with limited evidence-based pharmacologic options.

Arcari L, Camastra G, Sclafani M et al. · International journal of cardiology · (2026) · 1 citations · View on PubMed ↗

Dilated cardiomyopathy vs. non-dilated left ventricular dysfunction: genotype-phenotype relationship and outcome.

This study investigated genotype–phenotype relationships and outcomes in patients with dilated cardiomyopathy (DCM) versus non-dilated left ventricular dysfunction (NDLVD), using comprehensive clinical, genetic, and CMR assessment with LV ejection fraction (LVEF) <57%. Patients were classified as DCM or NDLVD based on LV end-diastolic volume thresholds, excluding coronary artery disease and other specific cardiac/inflammatory/infiltrative causes, and the primary endpoint was a composite cardiovascular outcome. Clarifying how genetic and CMR-defined phenotypes map to prognosis could improve risk prediction and stratification for patients with LV systolic dysfunction.

Bellisario I, Aimo A, Todiere G et al. · International journal of cardiology · (2026) · View on PubMed ↗

Cardiac magnetic resonance-derived left atrial strain restratifies patients with hypertrophic cardiomyopathy at low-risk of sudden cardiac death.

This retrospective longitudinal single-center study assessed whether CMR-derived left atrial global longitudinal strain (LA-GLS) improves risk stratification in 183 low-risk hypertrophic cardiomyopathy (HCM) patients with HCM Risk-SCD score <4%. LA-GLS derived from CMR was evaluated for predicting major adverse cardiovascular events (MACE) in this low-risk subgroup. If LA-GLS reclassifies risk effectively, it could refine prognostic assessment and guide follow-up intensity in HCM patients who are currently considered low risk by standard scoring.

Faggiano A, Casas G, Gonzalez-Santorum F et al. · European heart journal. Cardiovascular Imaging · (2026) · 1 citations · View on PubMed ↗

Role of concomitant endomyocardial biopsy in non-ischemic cardiomyopathy with ventricular arrhythmias.

The study assessed the diagnostic yield and clinical impact of performing concomitant endomyocardial biopsy (EMB) during electrophysiological procedures in patients with non-ischemic cardiomyopathy (NICM) presenting with ventricular arrhythmias (VAs). The key finding was that EMB findings led to changes in diagnosis in a substantial proportion of the 37 enrolled NICM patients undergoing EMB, indicating meaningful incremental diagnostic value. This is significant because it supports integrating EMB with electrophysiology workflows to refine etiologic diagnosis and potentially guide management in NICM-associated VAs.

Togashi D, Katsume Y, Uetake S et al. · Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · (2026) · View on PubMed ↗ · Free PDF ↗

Clinical Phenotypes in Hypertension: A Data-Driven Approach to Risk Stratification.

The study used unsupervised machine learning (k-means clustering) on 14,840 UK Biobank participants with hypertension and available cardiovascular magnetic resonance (CMR) to identify data-driven clinical phenotypes and relate them to imaging features and adverse outcomes. The key finding was that distinct hypertension phenotypes were associated with different CMR imaging characteristics and that cardiac imaging features mediated some of the associations with outcomes. This is significant because it enables more refined, imaging-informed risk stratification beyond traditional hypertension categories.

Rauseo E, Salih AM, Cooper J et al. · Hypertension (Dallas, Tex. : 1979) · (2026) · 1 citations · View on PubMed ↗ · Free PDF ↗

Left atrial epicardial adipose tissue volume quantification by CMR aids identification of patients at low risk for left atrial cardiomyopathy.

The study quantified left atrial epicardial adipose tissue (LA-EAT) volume by CMR in patients undergoing primary atrial fibrillation (AF) ablation to determine whether it predicts low risk for left atrial cardiomyopathy, operationalized by the presence of low-voltage zones (LVZ) on invasive electroanatomic mapping. The key finding was that higher or lower LA-EAT volume (as reported in the truncated results) helped identify patients at low risk for LVZ, linking adipose-mediated remodeling to atrial cardiomyopathy burden. This is clinically significant because LA-EAT quantification could improve noninvasive risk stratification and patient selection for AF ablation strategies.

Schmidt TR, Ulbrich S, Gaspar T et al. · Clinical research in cardiology : official journal of the German Cardiac Society · (2026) · View on PubMed ↗ · Free PDF ↗

Multiple 4q25 risk variants impair calcium homeostasis and compromise left atrial function.

This study tested whether multiple 4q25 atrial fibrillation risk variants (rs1448818, rs2200733, rs10033464) impair calcium homeostasis and left atrial function. Using UK Biobank data from 391,008 individuals, the risk alleles increased incident atrial fibrillation in a dose-dependent manner and showed additive effects of genetic and clinical risk, supporting SNP-specific calcium-related mechanisms. The findings provide mechanistic insight into how 4q25 variants compromise atrial function and may enable more targeted risk prediction or future interventions.

Jiménez-Sábado V, Tarifa C, Vad OB et al. · Cardiovascular research · (2026) · View on PubMed ↗ · Free PDF ↗

Prognostic Value of a Cardiac Magnetic Resonance-Derived Left Atrioventricular Coupling Index From Routine Cine Images in Dilated Cardiomyopathy: A Multicenter Study.

This multicenter retrospective study assessed whether a cardiac MRI-derived left atrioventricular coupling index (LACI) computed from routine cine images predicts adverse outcomes in dilated cardiomyopathy (DCM), using 403 patients split into training and internal validation cohorts. The key finding was that LACI provided prognostic value beyond conventional markers such as left ventricular ejection fraction (LVEF) and late gadolinium enhancement (LGE), improving risk stratification. Scientifically and clinically, it suggests that routine cine-derived atrial–ventricular coupling can capture remodeling interplay relevant to DCM outcomes.

Jiang YJ, Hou XC, Tao J et al. · Journal of magnetic resonance imaging : JMRI · (2026) · View on PubMed ↗

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Valvular Heart Disease & Structural Substrates

Gender differences in clinical phenotype, right-heart remodelling and outcomes in severe tricuspid regurgitation: a cardiac magnetic resonance study.

This multicenter cardiac magnetic resonance (CMR) study examined sex-related differences in clinical phenotype, right-heart remodeling, and all-cause mortality among patients with severe tricuspid regurgitation (TR) who had CMR after echocardiographic confirmation. Women had distinct right ventricular (RV) remodeling patterns and different mortality outcomes compared with men under medical therapy. These findings support sex-specific risk assessment and may refine prognostic interpretation of CMR measures in severe TR.

Hinojar R, Rodriguez Palomares J, Barreiro-Pérez M et al. · European heart journal. Cardiovascular Imaging · (2026) · 1 citations · View on PubMed ↗

Cardiac arrest secondary to mitral annular disjunction: a case report.

This case report studied a woman in her 40s with bileaflet mitral valve prolapse and mitral annular disjunction who suffered out-of-hospital ventricular fibrillation cardiac arrest. The patient achieved return of spontaneous circulation after multiple defibrillation shocks and prolonged resuscitation, with the underlying arrhythmogenic substrate attributed to mitral annular disjunction and associated ventricular ectopy/fibrosis risk. The report highlights mitral annular disjunction as a clinically important cause of malignant ventricular arrhythmia and sudden cardiac arrest that warrants careful risk recognition in patients with bileaflet mitral valve prolapse.

Smman A, Meurgey JH, Khiani R et al. · European heart journal. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗

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Arrhythmias, Electrophysiology & Sudden Cardiac Death

Time trends in ICD recommendations and predictors of device activation hypertrophic cardiomyopathy: a real-world cohort study.

This real-world retrospective cohort study assessed how evolving European Society of Cardiology (ESC) guideline recommendations for primary-prevention implantable cardioverter-defibrillator (ICD) implantation affected device activation and outcomes in 52 hypertrophic cardiomyopathy (HCM) patients receiving an ICD between 2014 and 2024. The key finding was that guideline-driven eligibility changes translated into measurable differences in real-world ICD activation/event detection over time. Clinically, this informs how guideline expansion impacts benefit and surveillance strategies for sudden cardiac death prevention in HCM.

Marques Antunes M, Carvalheiro R, Cardoso I et al. · International journal of cardiology. Heart & vasculature · (2026) · View on PubMed ↗ · Free PDF ↗

Prognostic impact of atrio-ventricular conduction abnormalities in non-ischemic cardiomyopathy.

This retrospective cohort study of 616 patients with non-ischemic cardiomyopathy (NICM) assessed whether atrioventricular block (AVB) on ECG adds prognostic value for ventricular arrhythmias in the context of cardiac MRI late gadolinium enhancement (LGE). The key finding was that AVB meaningfully stratified arrhythmic risk within contemporary NICM patients evaluated with CMR, addressing a gap in risk prediction among LGE-positive individuals. The results support incorporating AVB into arrhythmia risk models to improve selection for therapies such as appropriate implantable cardioverter-defibrillator (ICD) treatment.

Sanaú J, Di Marco A, Brown P et al. · Heart rhythm · (2026) · 1 citations · View on PubMed ↗

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Ischemia, Coronary Physiology & Myocardial Viability

Ferumoxytol-Enhanced Myocardial T1 Tracking Using a Hybrid 2D/3D Steady-State MRI Sequence Captures Cyclic Intramyocardial Blood Volume Dynamics.

This study investigated ferumoxytol-enhanced myocardial T1 tracking to detect cyclic intramyocardial blood volume (iMBV) dynamics from systole to diastole. The key finding was that a newly developed hybrid 2D/3D steady-state MRI sequence enabled measurement of cyclic iMBV dynamics on clinical scanners, supporting detection of coronary microcirculation changes without vasodilator stress. This is significant because it provides a potential noninvasive imaging biomarker for coronary artery disease and microvascular dysfunction.

Unal HB, Zeynali S, Ahmed A et al. · NMR in biomedicine · (2026) · View on PubMed ↗ · Free PDF ↗

A Case of the Uncommon Cause of Chronic Coronary Syndrome: Coronary Fistula and Coronary Stenosis, Which One to Intervene?

This case report studied diagnostic and interventional decision-making in a patient with chronic coronary syndrome (CCS) caused by two distinct mechanisms: a coronary fistula and coronary stenosis. Comprehensive noninvasive and invasive physiology and imaging were used before, during, and after intervention, revealing a mid-LAD stenosis of 50% alongside an unexpectedly high-flow LAD-to-main pulmonary artery fistula. The report is clinically significant because it emphasizes that CCS symptoms may reflect multiple coexisting coronary pathologies requiring tailored intervention strategy.

Sinurat MRMP, Taofan T, Tobing DPL et al. · The International journal of angiology : official publication of the International College of Angiology, Inc · (2026) · View on PubMed ↗ · Free PDF ↗

Prognostic value of cardiac magnetic resonance pulmonary transit time and myocardial strain across different stages of ST-elevation myocardial infarction.

This prospective prognostic study assessed whether cardiac MRI pulmonary transit time (PTT) and myocardial strain measured by 3.0-T CMR feature tracking predict outcomes across different ST-elevation myocardial infarction (STEMI) stages defined by CCS classification in 521 STEMI patients. The key finding was that PTT and global myocardial strain parameters (longitudinal, circumferential, radial) were associated with prognosis, with performance varying by CCS stage. Clinically, it supports using CMR perfusion timing and strain to refine risk stratification after STEMI beyond conventional clinical staging.

Hu YY, Zhang ZX, Li S et al. · European journal of radiology open · (2026) · View on PubMed ↗ · Free PDF ↗

Diagnostic yield of second-line functional imaging after an abnormal coronary computed tomography angiography: an individual patient-data meta-analysis.

This individual patient-data meta-analysis compared diagnostic performance of second-line functional imaging after abnormal coronary computed tomography angiography (CCTA) in 1410 patients, using invasive angiography with fractional flow reserve (FFR) as the reference standard. The key finding was that different functional tests (dobutamine stress echocardiography, SPECT, CMR, and/or PET) have varying diagnostic yields for identifying hemodynamically significant coronary stenosis after CCTA. This supports evidence-based selection of the most informative second-line modality following abnormal CCTA results.

Rasmussen LD, Hoek R, Westra J et al. · European heart journal. Cardiovascular Imaging · (2026) · 1 citations · View on PubMed ↗

Myocardial transit time mapping by CMR: A novel potential parameter of microcirculatory dysfunction in hypertrophic cardiomyopathy with and without atrial fibrillation.

The study investigated myocardial transit time (MyoTT) by cardiovascular magnetic resonance (CMR) as a marker of coronary microvascular dysfunction in hypertrophic cardiomyopathy (HCM) patients with and without atrial fibrillation (AF), compared with healthy controls. The key finding was that MyoTT (along with other CMR measures such as native T1 and extracellular volume) was evaluated for discriminating HCM vs controls and for distinguishing AF status within HCM. This is significant because MyoTT could provide a noninvasive CMR parameter to phenotype microcirculatory dysfunction and AF risk in HCM.

Yang J, Cheng Y, Yang J et al. · European journal of radiology open · (2026) · View on PubMed ↗ · Free PDF ↗

Prognosis and risk stratification in first-presentation myocardial infarction with nonobstructive coronary arteries using stress cardiac MRI.

This retrospective study evaluated prognosis and risk stratification in 279 patients with first-presentation myocardial infarction with nonobstructive coronary arteries (MINOCA) using stress cardiac MRI. Patients were categorized by cardiac MRI phenotype based on late gadolinium enhancement (LGE) and inducible ischemia, and major adverse cardiovascular events (MACE) were used as the primary outcome. The results support stress cardiac MRI phenotyping as a practical tool to identify MINOCA patients at higher risk for subsequent cardiovascular events.

Tang L, Long Q, Zhao W et al. · Insights into imaging · (2026) · View on PubMed ↗ · Free PDF ↗

Rentrop collateral grade predicts myocardial viability in chronic total occlusion on cardiac magnetic resonance.

This study evaluated whether angiographic Rentrop collateral grading predicts myocardial viability in 56 patients with chronic total occlusion (CTO) using quantitative cardiac magnetic resonance (CMR). Viable myocardium (defined as ≤50% transmural scar on late gadolinium enhancement) was associated with higher Rentrop collateral grades and differed in quantitative myocardial blood flow (MBF) and scar burden across CTO territories. These findings support using Rentrop collateral assessment to noninvasively infer tissue viability and potentially guide revascularization decisions in CTO patients.

Mehmood Z, Suresh P, Li R et al. · Open heart · (2026) · View on PubMed ↗ · Free PDF ↗

Interconnected Biatrial Myxoma Spanning the Fossa Ovalis: Management Based on Multimodality Imaging.

This case report described a 48-year-old man with acute myocardial infarction due to isolated spontaneous coronary artery dissection (SCAD) confined to the first septal perforator (S1), confirmed by coronary angiography and cardiac MRI. CMR demonstrated a transmural septal infarction, and the patient was managed conservatively with antiplatelet and beta-blocker therapy with an uncomplicated recovery. The case highlights that isolated S1 SCAD can present in men and may be effectively treated without intervention when clinically stable.

Herrera JCU, Madogolele HDCN, Nastari RR et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗

Diagnostic evaluation of myocardial infarction with non-obstructive coronary arteries in a young patient: suspected coronary embolism from a calcified bicuspid aortic valve.

This BMJ case report studied a young patient with acute ST-segment elevation myocardial infarction in whom coronary embolism was suspected to originate from a calcified bicuspid aortic valve. The key finding was that comprehensive coronary angiography showed no significant coronary disease while transthoracic echocardiography and cardiac magnetic resonance imaging supported nearly transmural infarction and the presence of severe calcific bicuspid aortic stenosis with moderate aortic regurgitation. The report is significant because it illustrates a rare mechanism—coronary embolism from a calcified bicuspid aortic valve—for MI in young patients with non-obstructive coronary arteries.

Ruksuthee C, Theerasuwipakorn N, Boonyaratavej S et al. · BMJ case reports · (2026) · View on PubMed ↗

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Heart Failure Phenotyping & Hemodynamics (including HFpEF/HFrEF)

End-diastolic forward flow (EDFF) after tetralogy of Fallot repair: Evolution of its role in management and prognosis.

This narrative review synthesized evidence on end-diastolic forward flow (EDFF) after tetralogy of Fallot (ToF) repair, focusing on how its interpretation has evolved from a marker of favorable restriction to a multifactorial hemodynamic phenomenon. The key conclusion is that EDFF reflects multiple determinants of restrictive RV physiology rather than a single, specific measure of myocardial stiffness. Scientifically, it clarifies how EDFF should be assessed and interpreted for diagnosis and prognosis in repaired ToF.

Baneu P, van Dijk AP, Duijnhouwer AL et al. · International journal of cardiology. Congenital heart disease · (2026) · View on PubMed ↗ · Free PDF ↗

Prognostic value of pulmonary transit time by cardiovascular MRI in heart failure with preserved ejection fraction.

This prospective cohort study evaluated whether pulmonary transit time (PTT) measured by cardiovascular MRI predicts adverse outcomes in adults with heart failure with preserved ejection fraction (HFpEF). The key finding was that prolonged CMR-derived PTT independently predicted worse clinical outcomes after adjustment for established HFpEF measures. This positions PTT as a noninvasive CMR marker of cardiopulmonary hemodynamics that may improve prognostic risk stratification in HFpEF.

Shergill S, Dattani A, Kanagala P et al. · Heart (British Cardiac Society) · (2026) · View on PubMed ↗

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Pulmonary Hypertension & Right-Heart Coupling

CMR-derived left ventricular pressure-volume loops enhance individualized assessment of disease severity and prognosis in pulmonary arterial hypertension in adults.

This study evaluated whether cardiovascular magnetic resonance (CMR)-derived left ventricular pressure–volume (PV) loops improve individualized assessment of disease severity and prognosis in adults with pulmonary arterial hypertension (PAH). In 96 PAH patients (median age 64, 70% women) and 32 matched healthy controls, CMR-based LV PV-loop metrics were computed and related to right heart catheterization data and clinical outcomes (death or lung transplantation). The findings support CMR PV-loop–based phenotyping as a prognostic tool in adult PAH beyond conventional hemodynamics.

Castiglione A, Bergström E, Kjellström B et al. · Physiological reports · (2026) · View on PubMed ↗

Enhancing Intermediate-Risk Stratification in Pulmonary Hypertension: CMR-Derived Quantification of Right Ventricular-Arterial Coupling.

This retrospective study tested whether CMR-derived right ventricular (RV)–arterial coupling quantified as stroke volume to end-systolic volume ratio (SV/ESV) improves prognostic stratification in pulmonary hypertension (PH) patients classified as intermediate-risk by the 2022 ESC/ERS four-strata model. The key finding was that SV/ESV reclassified intermediate-risk patients into intermediate-low and intermediate-high groups with different risks for the composite endpoint of clinical worsening (hospitalization for heart failure or death). This supports using CMR RV–arterial coupling to refine risk stratification beyond guideline risk categories in PH.

Tian H, Wu Q, Wang Z et al. · Academic radiology · (2026) · View on PubMed ↗

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Congenital Heart Disease & Pediatric Cardiovascular Imaging

Navigating Mechanical Support in Cardiogenic Shock With Arterial Hypoplasia: Lessons From Arterial Tortuosity Syndrome.

This case report studied mechanical circulatory support decisions in a 19-year-old man whose cardiogenic shock was the first presentation of arterial tortuosity syndrome (ATS) with severe arterial hypoplasia. The patient’s iliofemoral arteries (3 mm), ascending aorta (19 mm), and thoracic aorta were so hypoplastic and tortuous that both mechanical thrombectomy and peripheral VA-ECMO were technically unfeasible despite multimodality imaging (cranial CTA, aortic angiography, and cardiac MRI). The report highlights that ATS-related large-vessel hypoplasia can directly determine feasibility and strategy for life-saving cardiogenic shock interventions.

Lara-García A, Caro-Codón J, Canales L et al. · Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions · (2026) · View on PubMed ↗

The Role of Multimodality Imaging in the Evaluation of Heart Failure and Surgical Transplant Planning of Patients with Adult Congenital Heart Disease.

This article studied the role of multimodality cardiac imaging in evaluating heart failure and planning surgical transplant evaluation in adults with congenital heart disease (ACHD). It found that longitudinal, guideline-recommended surveillance imaging—performed at expert centers with condition-specific protocols—improves identification of residual lesions, ventricular dysfunction, and patients needing advanced therapy evaluation. The review is significant because it links imaging strategy to timely referral and surgical/transplant planning in complex ACHD populations.

Duarte VE, Rajpal S · Cardiac electrophysiology clinics · (2026) · View on PubMed ↗

Dual-Phase 3D Modified Dixon Steady-State MR Angiography in Pediatric Complex Congenital Heart Disease.

This retrospective study evaluated whether dual-phase 3D modified Dixon (mDixon) steady-state MR angiography (MRA) improves phase-dependent image quality and vessel measurement accuracy in pediatric complex congenital heart disease. Using 3T free-breathing dual-phase 3D mDixon MRA with respiratory navigator gating and interleaved diastolic/systolic acquisition, vessel diameters were measured by two readers and image quality was assessed across motion/flow/susceptibility-related factors. The results support a practical MRI technique to obtain more reliable vessel measurements in children with complex CHD.

Beissel LD, Hart C, Isaak A et al. · Radiology. Cardiothoracic imaging · (2026) · View on PubMed ↗

The role of advanced imaging in the diagnosis and management of scimitar syndrome in pediatric patients.

This pediatric imaging review studied how advanced imaging with cardiac CT and cardiovascular MRI (CMR) characterizes scimitar syndrome (Scimitar Syndrome, SS) and guides management. It found that CT/CMR can delineate SS variants—right anomalous pulmonary venous drainage to the hepatic vein/IVC, hypoplastic right lung and pulmonary artery, and associated aortopulmonary collaterals and malformations—linking anatomy to treatment planning. The clinical significance is improved diagnostic precision and more tailored surgical or rerouting strategies in children with this rare congenital cardiopulmonary anomaly.

Nguyen TVN, Emral HG, Voges I et al. · International journal of cardiology. Congenital heart disease · (2026) · View on PubMed ↗ · Free PDF ↗

The Rapid Long-axis Strain-based Prognostic Models Evaluate Composite Adverse Events for Asymptomatic Dextro-Transposition of the Great Arteries Patients after the Switch Operation.

This study evaluated whether biventricular strain and rapid long-axis strain (RLAS) can detect impaired mechanics and predict composite adverse events in asymptomatic dextro-transposition of the great arteries (d-TGA) patients after arterial switch operation (ASO). The key finding was that rapid long-axis strain–based prognostic models improved risk stratification for composite adverse events compared with conventional approaches. Clinically, strain-based CMR metrics could enable earlier identification of high-risk ASO survivors for closer follow-up or intervention.

Hu L, Guo C, Liu X et al. · Academic radiology · (2026) · View on PubMed ↗

Multimodality imaging of patent ductus arteriosus with severe pulmonary hypertension following 3 pregnancies.

This case report studied a 46-year-old woman with previously unrecognized patent ductus arteriosus (PDA) presenting with exertional chest discomfort and severe pulmonary hypertension after three pregnancies, using multimodality imaging plus right- and left-heart catheterization. Imaging showed right ventricular dilation/dysfunction and pulmonary arterial pressures at systemic levels with bi-directional shunting confirmed invasively. The report highlights that adult PDA can be missed and can progress to systemic-level pulmonary vascular disease, supporting comprehensive imaging and hemodynamic assessment when pulmonary hypertension is unexplained.

Corsi D, Mousa A, Patel D et al. · Radiology case reports · (2026) · View on PubMed ↗ · Free PDF ↗

Flow Hemodynamics in Children with Tetralogy of Fallot: A Comparison Study of Cardiac Catheterization and Phase-Contrast MRI.

This comparison study evaluated pulmonary flow hemodynamics in 33 repaired tetralogy of Fallot (TOF) patients (children) by contrasting invasive cardiac catheterization using the Fick principle with phase-contrast cardiac MRI (PC-MRI). PC-MRI was emphasized as directly measuring blood flow and regurgitant fraction, whereas Fick-based estimates can be inaccurate due to assumptions about oxygen consumption and effects of pulmonary regurgitation. Clinically, the work supports PC-MRI as a more reliable noninvasive approach for lifelong pulmonary surveillance in repaired TOF.

Berthusen AJ, Saucedo JG, Schäfer M et al. · Pediatric cardiology · (2026) · View on PubMed ↗

Measuring Atrioventricular Valve Regurgitation in Fontan Patients Using Cardiac MRI and the Association with Clinical Outcomes: A FORCE Study.

This multicenter FORCE study evaluated how cardiac magnetic resonance (CMR) quantification of atrioventricular valve regurgitation (AVVR) in Fontan patients compares with echocardiographic AVVR and how CMR AVVR relates to clinical outcomes. The key finding was that quantitative CMR regurgitant fraction measurements were used alongside matched echocardiographic severity categories to assess prognostic associations in the Fontan Outcome Registry using CMR Examination. This is clinically significant because it supports CMR-based, quantitative AVVR assessment as a potentially more informative predictor of long-term post-Fontan adverse outcomes than categorical echocardiographic grading.

Li Y, Schiff M, Olivieri L et al. · Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · (2026) · View on PubMed ↗ · Free PDF ↗

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Cardio-Oncology (Cancer Therapies & Cardiotoxicity/Imaging)

Cardiac Biomarkers and Multimodality Imaging in Surveillance During Oncologic Therapy: An Integrated Approach to Cardio-Oncology.

This review studied how cardiac biomarkers and multimodality imaging are used for surveillance during oncologic therapy across major cancer-treatment classes (anthracyclines, HER2-targeted therapies, VEGF inhibitors, immune checkpoint inhibitors) and chest radiotherapy. It found that the 2022 European Society of Cardiology cardio-oncology guidelines provide a structured framework for early detection of cancer therapy–related cardiovascular toxicity using biomarkers and advanced imaging. The integrated approach is clinically significant because it standardizes monitoring to identify cardiotoxicity earlier and guide management during cancer treatment.

Agrawal SP, Lussier A, Patel DS et al. · Cardiology in review · (2026) · View on PubMed ↗

Molecular imaging of lymphatic organs provides prognostic value after acute myocardial infarction.

This prospective nuclear medicine study (NCT05519735) investigated whether molecular imaging of lymphatic organs predicts functional recovery after acute myocardial infarction (AMI) in 41 timely re-perfused STEMI patients. Participants underwent baseline 68Ga-PentixaFor PET targeting CXCR4-expressing leukocytes, and uptake in remote lymphatic organs (spleen, bone marrow, and heart-draining lymph nodes) was used to identify individuals predisposed to better follow-up recovery. The work suggests that CXCR4 leukocyte imaging in lymphatic tissues can serve as an early prognostic biomarker for post-AMI outcomes.

Reiter T, Dörrler AL, Hasenauer N et al. · European journal of nuclear medicine and molecular imaging · (2026) · 1 citations · View on PubMed ↗ · Free PDF ↗

Machine Learning Model Using Pre-Cancer Therapy Cardiac Magnetic Resonance Images to Predict Cancer Therapy-Related Cardiac Dysfunction.

This multicenter deep learning study evaluated whether pre-treatment cardiac MRI images can predict cancer therapy-related cardiac dysfunction (CTRCD) in women with HER2+ breast cancer receiving anthracyclines and trastuzumab, comparing a CMR-based model against clinical and conventional imaging approaches. The key finding was that a deep learning model trained on pre-cancer therapy CMR images improved prediction of subsequent CTRCD (as defined by CMR criteria) relative to comparator models. Clinically, this supports using routine baseline CMR with AI to identify patients at higher risk for CTRCD before cardiotoxic therapy.

Yu C, Peikari M, Labib D et al. · JACC. Cardiovascular imaging · (2026) · View on PubMed ↗

COVID-19 outcomes and persistent symptoms in patients with hypertrophic cardiomyopathy: association with pre-existing cardiovascular magnetic resonance phenotype.

This registry-based observational study assessed whether pre-existing cardiovascular MRI (CMR) phenotypes in 1704 participants with hypertrophic cardiomyopathy (HCM) were associated with COVID-19 outcomes and impaired recovery (≥3 months) among 767 patients who reported infection. The key finding was that specific baseline CMR features were associated with higher risk of hospitalization and/or worse longer-term recovery after COVID-19. Scientifically, it suggests that CMR-defined myocardial phenotype can stratify COVID-19 vulnerability in HCM patients.

Singhal A, Appleby E, Agnel O et al. · Heart (British Cardiac Society) · (2026) · View on PubMed ↗

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Immunotherapy-Related Cardiac Complications (ICI myocarditis/vasculitis/spasm)

Clinical Features, Treatment, and Outcomes of Sintilimab-Induced Myocarditis.

This retrospective study examined the clinical features, treatment, and outcomes of myocarditis induced by the immune checkpoint inhibitor sintilimab. Across 34 reported cases (median age 64; 67.6% male), myocarditis onset ranged from 1 to 120 days post-treatment (median 21 days), with common symptoms including dyspnea (41.2%) and chest tightness (35.3%), and the study summarized management and outcomes from published case reports. The findings are significant for clinicians because they characterize timing, presentation, and real-world management patterns of sintilimab-associated myocarditis to support earlier recognition and treatment.

Liu M, Sun W, Pan Y et al. · Journal of immunotherapy (Hagerstown, Md. : 1997) · (2026) · View on PubMed ↗

Isolated First Septal Perforator Spontaneous Coronary Artery Dissection Causing Acute Myocardial Infarction.

This case report described a 53-year-old man with metastatic clear-cell renal cell carcinoma receiving ipilimumab plus nivolumab who developed ST-segment elevation myocardial infarction–like symptoms due to coronary vasospasm and immune checkpoint inhibitor (ICI)-associated myocarditis. Coronary angiography showed severe triple-vessel disease without a culprit lesion and repeat angiography demonstrated resolution consistent with vasospasm, while CMR confirmed myocarditis. The report emphasizes that ICI therapy can cause overlapping coronary spasm and myocarditis that may mimic acute coronary syndrome and require prompt recognition.

Karlsson RA, Birrane JP, O’Hanlon R et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗

Migrainous Thoracalgia in a Patient with Chronic Migraine and Coronary Vasospasm: A Case Report.

This case report described a 57-year-old woman with chronic migraine who developed recurrent migrainous thoracalgia/chest pain associated with coronary vasospasm and microvascular disease. Despite extensive cardiac workup including cardiac MRI and catheterization, the final diagnosis included fibromuscular dysplasia, spontaneous coronary artery dissection, and coronary microvascular disease, with partial symptom response to nitroglycerin and modest improvement with migraine-directed therapy using ubrogepant and calcium channel blockers. The case supports considering a neurologic-migraine contribution to chest pain even when coronary vasospasm and microvascular pathology are present.

Zeldich D, Wang VS, David C et al. · International medical case reports journal · (2026) · View on PubMed ↗

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Pharmacology & Anti-inflammatory/Metabolic Cardioprotection

Prediction of Anthracycline-induced Cardiotoxicity Using Cardiac MRI Parameters: An Animal Study.

This animal study evaluated whether cardiac MRI native T1 and extracellular volume fraction (ECV) can predict early mortality in Sprague-Dawley rats treated with weekly intravenous doxorubicin (2 mg/kg). The key finding was that MRI parametric mapping variables (native T1 and ECV) were associated with time-to-early death in the preclinical anthracycline-induced cardiotoxicity model. Scientifically, it supports using CMR T1/ECV as early, quantitative biomarkers of anthracycline cardiotoxic risk before overt clinical endpoints.

Kim NY, Park J, Park HS et al. · Radiology. Cardiothoracic imaging · (2026) · View on PubMed ↗

Effect of Interleukin-6 Receptor Inhibition by Tocilizumab on Platelet Activation and Markers of Thrombus Formation: A Substudy of the ASSAIL-MI Trial.

This ASSAIL-MI trial substudy investigated whether IL-6 receptor inhibition with tocilizumab alters platelet activation and thrombus-formation biomarkers in patients with myocardial infarction. The key finding was that tocilizumab treatment modulated soluble markers of platelet activation (e.g., P-selectin, sCD40L) and coagulation/thrombus-related factors (e.g., tissue factor, TFPI, PAI-1, D-dimer). Scientifically, it links anti-inflammatory IL-6R blockade to measurable coagulation/platelet pathway effects, supporting a mechanistic rationale for improved post-MI outcomes.

Ueland T, Dahl TB, Michelsen A et al. · Arteriosclerosis, thrombosis, and vascular biology · (2026) · View on PubMed ↗

Smoking cessation after first STEMI enhances infarct healing: a cardiac MRI study.

This prospective cardiac MRI study evaluated infarct dynamics in 672 revascularized first-time ST-elevation myocardial infarction (STEMI) patients who documented smoking behavior at baseline and after 4 months, comparing those who quit smoking versus continued smoking. Patients who stopped smoking showed improved infarct healing over follow-up as assessed by serial CMR at baseline, 4 months, and 12 months. The findings support smoking cessation soon after STEMI as a modifiable factor that favorably alters myocardial infarct evolution, potentially improving long-term outcomes.

Troger F, Pamminger M, Reindl M et al. · European heart journal. Cardiovascular Imaging · (2026) · 1 citations · View on PubMed ↗ · Free PDF ↗

A high-fat diet nutritional intervention reprograms cardiac metabolism and improves systolic function in a pig model of heart failure with reduced ejection fraction.

This randomized pig model study investigated whether a high-fat diet (20% lard supplementation) can reprogram cardiac metabolism and improve systolic function in heart failure with reduced ejection fraction (HFrEF) induced by progressive coronary artery stenosis. Compared with control diet, high-fat diet treatment improved systolic function and shifted myocardial substrate use away from the HF-associated fatty-acid-to-glucose metabolic switch. The work supports nutritional/metabolic reprogramming as a potential therapeutic strategy to counter maladaptive cardiac energetics in HFrEF.

Galán-Arriola C, Pérez-Camargo D, Ferrarini A et al. · Basic research in cardiology · (2026) · View on PubMed ↗ · Free PDF ↗

Canagliflozin attenuates CMR-quantified myocardial fibrosis in individuals with type 2 diabetes mellitus at high cardiovascular risk: a randomised open-label controlled trial.

This randomized open-label controlled trial tested whether canagliflozin attenuates myocardial fibrosis measured by CMR in 45 high-cardiovascular-risk adults with type 2 diabetes mellitus and preserved or near-preserved systolic function (LVEF >50%). Using CMR quantification to assess myocardial fibrosis, cardiac structure/function, and microcirculation, the study aimed to determine whether SGLT2 inhibition provides cardiovascular protective effects beyond glycemic control. If confirmed, CMR-quantified antifibrotic effects of canagliflozin could support SGLT2 inhibitors as disease-modifying therapy in high-risk T2D.

Yan H, Liu J, Zhang Z et al. · Diabetologia · (2026) · View on PubMed ↗ · Free PDF ↗

Efficacy of low dose colchicine on left ventricular hypertrophy in patients with coronary artery disease: A randomized controlled trial.

This randomized controlled trial studied whether low-dose colchicine (0.6 mg daily) reduces left ventricular mass index (LVMI) measured by cardiac MRI over 48 weeks in patients with coronary artery disease (CAD), left ventricular hypertrophy (LVH), and controlled blood pressure. The key finding was that colchicine treatment produced a different (reported in the truncated results) change in LVMI compared with placebo after 48 weeks, supporting an anti-inflammatory effect on LVH progression. The clinical significance is that colchicine could become a pharmacologic strategy to mitigate LVH-related risk in CAD patients if the LVMI reduction is confirmed in the full results.

Chichareon P, Suwannanon R, Thungthienthong M et al. · British journal of clinical pharmacology · (2026) · 3 citations · View on PubMed ↗

Radiation induces diffuse extracellular remodeling of healthy myocardium in a dose- and time-dependent manner without a dense ablative effect.

This preclinical study in eight healthy canines examined how photon cardiac stereotactic body radiotherapy (cSBRT) doses up to 50 Gy affect healthy myocardium over time using cardiac MRI and histology. Radiation produced diffuse extracellular remodeling in a dose- and time-dependent manner without a dense ablative lesion effect. Scientifically, these data refine understanding of cSBRT mechanisms for ventricular tachycardia and can guide dose/substrate targeting strategies to balance efficacy and safety.

Paccione EN, Kwan E, Bergquist JA et al. · Heart rhythm · (2026) · 2 citations · View on PubMed ↗

Repurposing Empagliflozin for Duchenne Muscular Dystrophy-Associated Cardiomyopathy: Protocol for a Pharmacokinetics, Safety and Proof-of-Concept Trial in Children.

This protocol describes a single-arm, open-label phase 2 pharmacokinetics, safety, and proof-of-concept trial repurposing empagliflozin in children with Duchenne muscular dystrophy (DMD)-associated cardiomyopathy. The study will characterize empagliflozin pharmacokinetics, assess safety and ease-of-swallow, and explore efficacy and efficacy biomarkers in this pediatric population. If successful, it could establish a rationale for SGLT2 inhibition as a disease-relevant therapy to reduce heart failure morbidity and mortality in DMD.

Lava SAG, Laurence C, Mallory J et al. · Cardiology and therapy · (2026) · View on PubMed ↗

C-X-C motif chemokine ligands (CXCL1/CXCL9) in inflammatory pathways underlying epilepsy-related ventricular remodeling: a mendelian randomization study.

This Mendelian randomization study used genetic instruments for epilepsy (including generalized and focal epilepsy) to test whether inflammatory plasma proteins involving CXCL1 and CXCL9 mediate epilepsy-related cardiac structural and functional remodeling, using 82 cardiac traits measured by cardiac MRI and ECG. The key finding was that genetically predicted CXCL1/CXCL9-linked inflammatory signaling was associated with epilepsy-related ventricular remodeling patterns, supporting a causal inflammatory pathway. These results implicate CXCL1/CXCL9 as potential mechanistic targets for preventing or mitigating epilepsy-associated cardiac remodeling.

Wang L, Liu G, Wang Y et al. · Acta neurologica Belgica · (2026) · View on PubMed ↗

SGLT2 inhibitors are associated with reductions in epicardial adipose tissue volume and thickness: a meta-analysis.

This systematic review and meta-analysis examined whether sodium-glucose co-transporter-2 inhibitors (SGLT2 inhibitors) reduce epicardial adipose tissue (EAT) volume and thickness in studies with serial EAT measurements using CT or echocardiography. Across included trials, SGLT2 inhibitor therapy was associated with reductions in EAT volume and thickness compared with baseline and/or control therapy. These findings support a potential cardiometabolic mechanism of SGLT2 inhibitors involving remodeling of metabolically active pericardial fat.

Khanna S, Kalman E, Thungathurthi K et al. · International journal of obesity (2005) · (2026) · View on PubMed ↗ · Free PDF ↗

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Non-cardiac/Population & Public Health/Other

A rapid phage-free platform for antigen-specific VNAR screening with BATCH system.

This methods paper studied a rapid phage-free platform for antigen-specific VNAR (shark single-domain antibody) screening using the BATCH system. Using a Cre recombinase–immunized Chiloscyllium plagiosum spleen cDNA library (~10^8 diversity) in BTH101 cells with dual lacZ and CmR readouts, the authors screened against pKT25c-Cre and identified two unique VNAR binders (VNAR1a and VNAR1b). The approach is significant because it expands VNAR discovery beyond phage display with a faster, phage-free bacterial two-hybrid workflow.

Tang W, Hu J, Zhu Y et al. · Protein science : a publication of the Protein Society · (2026) · View on PubMed ↗ · Free PDF ↗

Absolute and workload-indexed exercise blood pressure responses: associations with cardiac output, vascular resistance, and cardiorespiratory fitness in females.

This study examined associations between absolute and workload-indexed exercise systolic blood pressure (SBP) responses and hemodynamics (cardiac output and vascular resistance) as well as cardiorespiratory fitness in 135 adult females undergoing cardiopulmonary exercise testing. The key finding was that SBP response patterns—stratified by SBPmax and workload-indexed SBP (SBP/W-slope)—related to peak cardiac output and V̇o2peak across a broad fitness spectrum. Scientifically and clinically, it suggests that exercise SBP metrics can serve as practical surrogates for pressure–flow physiology and help refine interpretation of exercise capacity and cardiovascular risk.

Janssens K, Howden EJ, Mitchell AM et al. · American journal of physiology. Heart and circulatory physiology · (2026) · View on PubMed ↗

Forecasting mortality and decomposition analysis for cancer deaths in Egypt (2014-2030).

This population-level modeling study analyzed cancer mortality in Egypt from 2014–2023 and forecasted trends through 2030 for 19 cancer types using a hybrid ARIMA–ETS time-series approach and decomposition analysis. The key finding was that projected cancer mortality would increase, with decomposition attributing changes to population growth, population aging, and age-specific mortality rates. The significance is that these quantified drivers can inform Egyptian public health planning and resource allocation for cancer control.

Elshishiney G, Li M, Zou Y et al. · Cancer epidemiology · (2026) · View on PubMed ↗

Real-world multi-institution analysis of tarlatamab in patients with small cell lung cancer.

This multicenter retrospective real-world analysis evaluated outcomes of tarlatamab in small cell lung cancer (SCLC) patients who received at least one dose between 5/16/2024 and 6/15/2025 across three US institutions. The key finding was that a substantial “trial-ineligible” subgroup (e.g., poorer performance status and/or prior pneumonitis/interstitial lung disease history) had outcomes that differ from those expected from clinical-trial populations. Clinically, it helps define the effectiveness and safety expectations of tarlatamab in broader practice, including patients who would not meet trial eligibility criteria.

Cooper AJ, Liang J, McDonald S et al. · Lung cancer (Amsterdam, Netherlands) · (2026) · View on PubMed ↗ · Free PDF ↗

Three-Hour Infusion of Methotrexate at 3 g/m2 With or Without Intrathecal Chemotherapy Significantly Reduces CNS Relapses and Improves Survival in Patients With Large B-Cell Lymphomas at Increased CNS Risk.

This pharmacokinetic-informed clinical study evaluated a CNS-directed high-dose methotrexate (HD-MTX) regimen—3 g/m2 infused over 3 hours with a preceding bolus, with or without intrathecal chemotherapy—in 336 large B-cell lymphoma (LBCL) patients at increased CNS risk who achieved complete metabolic response on CMR after RCHOP or derivatives. The protocol significantly reduced CNS relapses and improved survival, using updated CNS risk criteria (e.g., CNS-IPI ≥4 and/or multiple extranodal sites or specific organ involvement). The results support a dosing-schedule–optimized HD-MTX strategy to improve CNS prophylaxis effectiveness in high-risk LBCL.

Ferreri AJM, Erbella F, Angelillo P et al. · American journal of hematology · (2026) · View on PubMed ↗

Generation of three heterozygous and two homozygous hiPSC lines from a CPVT associated mutation RYR2_p.G357S from a large family of the Canary Islands.

This stem cell research article generated induced pluripotent stem cell (hiPSC) lines from a large Canary Islands family carrying a catecholaminergic polymorphic ventricular tachycardia (CPVT) mutation in RYR2 (RYR2_c.G1069A/p.G357S). Using non-integrative episomal plasmids, the authors reprogrammed skin fibroblasts from three heterozygous and two homozygous carriers and produced hiPSC lines with normal karyotype, pluripotency marker expression, and differentiation into cells of all three germ layers. These patient-specific hiPSC models provide a genetic platform to study CPVT mechanisms and test RYR2-targeted or arrhythmia-modifying therapies.

Carreras D, Martínez-Moreno R, Selga E et al. · Stem cell research · (2026) · View on PubMed ↗ · Free PDF ↗

Electronic tools to facilitate medication review in nursing homes: a pilot study.

This pilot implementation study evaluated electronic tools (GheOP³S-tool and EBMeDS®CMR) to facilitate medication reviews (MRs) in nursing home residents by community pharmacists. In a single nursing home (Jan–Jul 2024), the tools were used in a structured 3-step MR workflow to detect potential drug-related problems (pDRPs) and assess clinical and economic impact. The study supports that decision-support software can reduce the time burden of MR and improve identification of medication-related problems in long-term care settings.

Carrein M, Capiau A, Mehuys E et al. · Acta clinica Belgica · (2026) · View on PubMed ↗

Interfacial polarisation, electrical modulus and relaxation dynamics in composite ceramics for multiferroic applications.

This materials study examined how changing composition in (1-x)BaTi0.9Zr0.1O3 + (x)Li0.5Fe2.5O4 composite ceramics (x = 0.00–0.15) affects interfacial polarization, dielectric behavior, and electrical relaxation dynamics. Increasing Li0.5Fe2.5O4 content reduced grain size and increased dislocation density, which enhanced interfacial polarization and produced frequency- and temperature-dependent dielectric properties with non-Debye relaxation behavior. These findings inform the design of multiferroic ceramic composites by linking microstructure and interfacial effects to dielectric performance.

Gajula GR, Buddiga LR, Srinivas G et al. · Journal of colloid and interface science · (2026) · View on PubMed ↗

Mortality patterns in patients with chronic obstructive pulmonary disease and diabetes mellitus in the United States: a retrospective analysis from 1999 to 2019.

This retrospective analysis used the CDC WONDER database to characterize mortality patterns associated with chronic obstructive pulmonary disease (COPD) and diabetes mellitus (DM) in the United States from 1999 to 2019. Joinpoint regression estimated trends including annual percent change (APC) and average APC (AAPC), with reported differences by sex and demographic groups. Understanding long-term mortality trends and disparities can guide public health targeting and resource allocation for COPD–DM comorbidity.

Fatima M, Fatima F, Raza A et al. · Journal of diabetes and metabolic disorders · (2026) · 1 citations · View on PubMed ↗ · Free PDF ↗

Development of Antibody-Drug Conjugates Targeting L1CAM to Treat Metastatic Cancer.

The study developed antibody-drug conjugates (ADCs) targeting L1 cell adhesion molecule (L1CAM) to eliminate drug-resistant metastatic cancer stem cells (MetSCs) in metastatic cancer models. The key finding was that L1CAM-directed ADCs were designed as a selective strategy to target MetSCs that drive relapse and chemotherapy resistance. This is scientifically significant because it supports L1CAM as a therapeutic surface target and advances ADC approaches aimed at preventing metastatic recurrence.

Park JS, Kenum C, He L et al. · Molecular cancer therapeutics · (2026) · 1 citations · View on PubMed ↗ · Free PDF ↗

Trastuzumab deruxtecan: An antibody-drug conjugates for non-small cell lung cancer.

This narrative review summarized evidence for trastuzumab deruxtecan (T-DXd), an antibody-drug conjugate, in HER2-mutant metastatic non-small cell lung cancer (NSCLC) after prior systemic therapy. The key finding was that the review compiles clinical trial and real-world evidence supporting T-DXd’s efficacy and characterizing its safety profile and adverse event management in this population. This is significant for clinical decision-making because it consolidates up-to-date outcomes and toxicity considerations for HER2-mutant metastatic NSCLC treated with T-DXd.

Siddiqui N, Sravanthi G, Reddy KJK et al. · Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners · (2026) · View on PubMed ↗

Hypoplastic Left Heart Syndrome in U.S. Children: A 20-Year Look at Lives Lost and Gaps That Remain.

This study analyzed CDC WONDER death certificate data to assess trends in hypoplastic left heart syndrome (HLHS)-related mortality among U.S. children from 1999 to 2020, stratifying by age, sex, race, urbanization, and geography. HLHS-related mortality trends over time were evaluated using age-adjusted and crude mortality rates per 1,000,000 population. The findings highlight persistent gaps in outcomes for a uniformly fatal congenital defect when untreated and can inform targeted public health and clinical interventions to reduce preventable deaths.

Siddiqi AK, Maniya MT, Ali KM et al. · Pediatric cardiology · (2026) · View on PubMed ↗

Reversible alterations of brain acetate metabolism associated with alcohol consumption.

This human neuroimaging study investigated reversible changes in brain acetate metabolism after alcohol consumption by comparing light drinkers, at-risk heavy drinkers, and individuals with alcohol use disorder (AUD) in long-term recovery and AUD treatment-seeking groups scanned at about one week of abstinence. The key finding was that brain acetate metabolism alterations associated with alcohol exposure were detectable and could normalize or shift with abstinence status. These results advance mechanistic understanding of how AUD affects brain energy metabolism and may identify metabolic targets for intervention.

Kumaragamage C, Jiang L, Angarita GA et al. · Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · (2026) · View on PubMed ↗ · Free PDF ↗

Spatial and spectrotemporal features of noise alter female responses to costly male signals in Cope’s gray treefrog (Hyla chrysoscelis).

This behavioral neuroethology study tested how spatial release from masking (SRM) and comodulation masking release (CMR) affect female mate choice for energetically costly male calls in Cope’s gray treefrog (Hyla chrysoscelis) using two-alternative phonotaxis tests under multiple noise treatments. Females showed altered response probability, chosen-male calling effort, and response latency depending on how noise was spatially separated from signals and spectrotemporally correlated with them. The findings clarify how noise structure can bias sexual selection by changing the ability to detect and prefer high-cost signals.

Ward JL, Lee N, Kalra L et al. · Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · (2026) · View on PubMed ↗ · Free PDF ↗

Nivolumab with or without vinblastine for first-line treatment of elderly patients with Hodgkin lymphoma and coexisting medical conditions: the Niviniho phase II Lysa study.

This phase II LYSA NIVINIHO trial evaluated first-line nivolumab alone versus nivolumab plus vinblastine in elderly (≥61 years) treatment-naive Hodgkin lymphoma patients with comorbidities precluding standard chemotherapy. The key finding was that an induction strategy of nivolumab followed by response-adapted consolidation achieved clinically meaningful complete metabolic response rates, with treatment intensification (adding vinblastine) reserved for patients with stable disease or partial response. These results support an immunotherapy-first, comorbidity-adapted regimen for older HL patients who cannot receive conventional chemotherapy.

Lazarovici J, Amorim S, Bouabdallah K et al. · Haematologica · (2026) · View on PubMed ↗ · Free PDF ↗

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Generated automatically on June 01, 2026. Covers PubMed articles published May 25, 2026 – June 01, 2026. Summaries are AI-generated; always consult the original publication for clinical or research decisions.