What’s New in Cardiac MRI?

June 02, 2026 · 94 articles · 15 research themes · covering May 26, 2026 – June 02, 2026

Overview

Across this week’s PubMed set, a dominant theme is the rapid expansion of cardiac MRI (CMR) as a quantitative, prognostic “biomarker platform” that goes beyond traditional measures. Multiple studies used CMR-derived tissue characterization (e.g., T1/ECV, native T1/T2, edema concepts), mechanics (strain, rapid long-axis strain), and hemodynamic metrics (pulmonary transit time, 4D-flow energy dissipation, pressure–volume loop parameters, atrioventricular/left atrial coupling indices) to refine risk stratification in conditions such as dilated cardiomyopathy, hypertrophic cardiomyopathy, pulmonary hypertension, valvular disease, and post–STEMI remodeling. Importantly, several papers show incremental value over standard clinical staging or ejection fraction—suggesting that CMR can detect “subclinical” disease burden and reclassify patients into more actionable risk groups.

A second major thread is the convergence of CMR with computational methods—especially machine learning and advanced reconstruction—to make imaging more scalable, reproducible, and clinically usable. Studies ranged from interpretable semi-federated learning for multimodal risk prediction, AI-assisted RV quantification, automated microvascular obstruction (MVO) heterogeneity for STEMI outcomes, and radiomics/radiomics-like approaches for diastolic dysfunction, coronary microvascular dysfunction, and pediatric myocarditis signatures. Parallel advances in acquisition/reconstruction (motion-robust free-breathing LGE, accelerated cine, ferumoxytol-enhanced whole-heart approaches, and new motion-correction pipelines) aim to reduce scan burden and improve image quality—key prerequisites for routine adoption.

Finally, the digest highlights a translational and therapeutic layer that links inflammation, immune modulation, and targeted interventions to measurable cardiovascular biology. Anti-inflammatory strategies (colchicine, IL-6 receptor inhibition) were tied to changes in cardiac remodeling and thrombosis/platelet activation pathways, while SGLT2 inhibitors and radiotherapy for amyloidosis explored mechanistic CMR endpoints. In parallel, cardio-oncology work emphasized imaging and biomarker surveillance for therapy-related cardiac dysfunction, and several oncology-focused studies (including antibody-drug conjugates and immune checkpoint inhibitor–associated myocarditis) underscore how cardiovascular imaging is increasingly central to cancer care and safety monitoring.

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Cardiac MRI/CMR biomarkers for prognosis and risk stratification

Association of Mitral Annular Disjunction on Magnetic Resonance Imaging With Cardiovascular Outcomes.

This prospective CMR registry analysis studied the prevalence and prognostic impact of mitral annular disjunction (MAD) on cardiovascular outcomes in 1969 patients, and examined associations with native T1 relaxation times measured at end-systole and end-diastole. The key finding was that MAD on CMR was associated with cardiovascular outcomes and showed relationships with native T1 relaxation, consistent with underlying myocardial tissue abnormalities. Scientifically, it strengthens CMR MAD as a clinically relevant imaging biomarker and links it to measurable myocardial characterization via T1 mapping.

Mascherbauer K, Nantschev N, Kronberger C et al. · European journal of clinical investigation · (2026) · View on PubMed ↗

Biventricular dysfunction and blood oxygenation deficits in obstructive sleep apnea: a prospective study with non-contrast cardiac MRI.

This prospective study evaluated whether non-contrast cardiac MRI measures of biventricular function, mechanics, and tissue characteristics (native T1 and T2 mapping) differ between severe and non-severe obstructive sleep apnea (OSA) in 75 newly diagnosed patients. The key finding was that severe OSA showed detectable subclinical cardiac abnormalities on non-contrast CMR and that these imaging changes correlated with markers of nocturnal hypoxemia. This supports non-contrast CMR as an early risk stratification tool in OSA by linking hypoxemia-driven myocardial effects to measurable tissue and functional alterations.

Wang J, Cheng Z, Du J et al. · BMC medical imaging · (2026) · View on PubMed ↗

Cardiac MRI in Depiction of Myocardial Edema: A Comprehensive Review.

This comprehensive review synthesized current knowledge on cardiac MRI approaches for detecting myocardial edema across ischemic, inflammatory, infiltrative, toxic, infectious, and autoimmune conditions. It emphasizes practical imaging strategies, common artifacts, differential diagnoses, and how edema detection supports risk stratification. The review is significant for standardizing interpretation of myocardial edema on MRI and improving diagnostic accuracy in diverse cardiac diseases.

Onder O, Kosanovich C, Kirshenboim ZE et al. · Radiographics : a review publication of the Radiological Society of North America, Inc · (2026) · View on PubMed ↗

Absolute and workload-indexed exercise blood pressure responses: associations with cardiac output, vascular resistance, and cardiorespiratory fitness in females.

This study used cardiopulmonary exercise testing in 135 adult females (51±8 years) to relate absolute and workload-indexed systolic blood pressure (SBP) responses to cardiac output, vascular resistance, and cardiorespiratory fitness (V̇o2peak). SBP responses were stratified by SBPmax (≥190 vs <190 mmHg) and by workload-indexed SBP slope (SBP/W-slope), and associations were evaluated with hemodynamic measures. The findings clarify how pressure–flow relationships during exercise reflect fitness and cardiovascular hemodynamics, potentially improving interpretation of exercise BP responses in women.

Janssens K, Howden EJ, Mitchell AM et al. · American journal of physiology. Heart and circulatory physiology · (2026) · View on PubMed ↗

An indolent course of undifferentiated pleomorphic cardiac sarcoma mimicking myxoma: A case report.

This case report studied a 71-year-old woman with cardiac undifferentiated pleomorphic sarcoma (UPS) that initially mimicked a myxoma on imaging, using serial cardiac magnetic resonance imaging and subsequent surgical pathology with immunohistochemistry. Follow-up imaging over two years showed progressive atrial septal/lesion growth that was ultimately interpreted as myxoma, but histopathology confirmed high-grade UPS. The report highlights the clinical importance of considering rare malignant cardiac tumors in the differential diagnosis when imaging findings evolve or remain atypical for myxoma.

Ziaei H, Palmquist E, Fagman H et al. · Radiology case reports · (2026) · View on PubMed ↗ · Free PDF ↗

Cardiac magnetic resonance-derived left atrial strain restratifies patients with hypertrophic cardiomyopathy at low-risk of sudden cardiac death.

This retrospective longitudinal single-center study assessed whether CMR-derived left atrial global longitudinal strain (LA-GLS) improves risk stratification for major adverse cardiovascular events (MACE) in 183 patients with hypertrophic cardiomyopathy (HCM) who were classified as low-risk by the HCM Risk-SCD score (<4%). LA-GLS re-stratified these low-risk patients, identifying subgroups with different MACE risk despite low baseline sudden cardiac death risk. Incorporating CMR LA-GLS could refine prognostic counseling and follow-up intensity in HCM patients who otherwise appear low-risk by standard SCD scoring.

Faggiano A, Casas G, Gonzalez-Santorum F et al. · European heart journal. Cardiovascular Imaging · (2026) · 1 citations · View on PubMed ↗

Role of concomitant endomyocardial biopsy in non-ischemic cardiomyopathy with ventricular arrhythmias.

This study evaluated the diagnostic yield and clinical impact of adding routine endomyocardial biopsy (EMB) during electrophysiological procedures in 37 consecutive patients with non-ischemic cardiomyopathy (NICM) complicated by ventricular arrhythmias (VAs). EMB findings led to changes in diagnosis based on clinical history, imaging, and genetic testing results. The results clarify when EMB is clinically valuable in NICM with VAs, informing diagnostic workup and management decisions.

Togashi D, Katsume Y, Uetake S et al. · Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · (2026) · View on PubMed ↗ · Free PDF ↗

Prognostic impact of atrio-ventricular conduction abnormalities in non-ischemic cardiomyopathy.

This retrospective cohort study evaluated whether atrioventricular block (AVB) on ECG adds prognostic value for ventricular arrhythmia outcomes in 616 patients with non-ischemic cardiomyopathy (NICM) who underwent cardiac MRI with late gadolinium enhancement (LGE). The key finding was that AVB was associated with increased risk of appropriate implantable cardioverter-defibrillator (ICD) therapy among contemporary NICM patients, including within the LGE+ subgroup where risk stratification is challenging. Clinically, incorporating AVB into CMR-based risk models could improve selection of patients for ICD therapy in NICM.

Sanaú J, Di Marco A, Brown P et al. · Heart rhythm · (2026) · 1 citations · View on PubMed ↗

Prognostic Value of a Cardiac Magnetic Resonance-Derived Left Atrioventricular Coupling Index From Routine Cine Images in Dilated Cardiomyopathy: A Multicenter Study.

This multicenter retrospective study evaluated whether a cardiac MRI-derived left atrioventricular coupling index (LACI) measured from routine cine images predicts adverse outcomes in dilated cardiomyopathy (DCM) patients. In 403 DCM patients split into training (n=282) and internal validation cohorts, the LACI showed prognostic value and provided incremental risk prediction beyond conventional markers such as left ventricular ejection fraction (LVEF) and late gadolinium enhancement (LGE). This could support more accurate, non-contrast or routine-cine–based risk stratification in DCM by capturing LA–LV remodeling interplay.

Jiang YJ, Hou XC, Tao J et al. · Journal of magnetic resonance imaging : JMRI · (2026) · View on PubMed ↗

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CMR for myocardial infarction (MI) outcomes, remodeling, and ischemia

Prognostic value of cardiac magnetic resonance pulmonary transit time and myocardial strain across different stages of ST-elevation myocardial infarction.

This prospective observational study assessed prognostic value of cardiac magnetic resonance (CMR) pulmonary transit time (PTT) and myocardial strain across Canadian Cardiovascular Society (CCS) stages in 521 STEMI patients. Using 3.0-T CMR with first-pass perfusion to measure PTT and CMR feature tracking to quantify global longitudinal, circumferential, and radial strain, the key finding was that PTT and strain metrics were associated with adverse outcomes after STEMI, with prognostic performance varying by CCS stage. The scientific significance is that CMR-derived hemodynamic (PTT) and functional (strain) measures may improve risk stratification beyond standard clinical staging in STEMI.

Hu YY, Zhang ZX, Li S et al. · European journal of radiology open · (2026) · View on PubMed ↗ · Free PDF ↗

Multi-biomarker approach for predicting cardiac magnetic resonance parameters at 30 days after ST-segment elevation myocardial infarction.

This pre-specified CLEVER-ACS substudy evaluated whether baseline biomarkers—high-sensitivity troponin T (hsTnT), NT-proBNP, CCN1, and PCSK9—predict cardiac magnetic resonance (CMR) infarct characteristics at 30 days after ST-segment elevation myocardial infarction (STEMI). The key finding was that specific baseline biomarker levels were associated with 30-day CMR parameters reflecting infarct size and tissue characteristics, indicating that early blood markers track intermediate post-infarction remodeling. The significance is that combining multi-biomarker profiles with 30-day CMR could refine post-STEMI risk assessment and guide follow-up intensity.

Horbach T, Wenzl FA, Manka R et al. · International journal of cardiology. Heart & vasculature · (2026) · View on PubMed ↗ · Free PDF ↗

Smoking cessation after first STEMI enhances infarct healing: a cardiac MRI study.

This prospective cardiac MRI study investigated infarct dynamics after smoking cessation in 672 revascularized first-time ST-elevation myocardial infarction (STEMI) patients, comparing active smoking status at baseline and after 4 months with CMR assessments at baseline, 4 months, and 12 months. The key finding was that quitting smoking after STEMI enhanced infarct healing over follow-up, reflected in improved infarct-related CMR measures compared with continued smoking. This is clinically significant because it provides imaging-based evidence that smoking cessation can beneficially modify post-MI myocardial remodeling.

Troger F, Pamminger M, Reindl M et al. · European heart journal. Cardiovascular Imaging · (2026) · 1 citations · View on PubMed ↗ · Free PDF ↗

Incremental prognostic value of left atrial strain for heart failure-related events following ST-Segment elevation myocardial infarction.

This study evaluated whether left atrial (LA) strain derived from cardiac magnetic resonance (MRI) adds prognostic value for heart failure (HF)–related events after ST-segment elevation myocardial infarction (STEMI) across different left ventricular ejection fraction (LVEF) levels. The key finding was that LA strain improved risk stratification for subsequent HF-related events beyond discharge LVEF, identifying patients at risk even when LVEF was normal. This is significant because it supports using LA strain as a sensitive CMR biomarker to predict post-STEMI HF outcomes and guide follow-up intensity.

Zhao Y, Chen XY, Zhu GJ et al. · European journal of radiology · (2026) · View on PubMed ↗

Prognosis and risk stratification in first-presentation myocardial infarction with nonobstructive coronary arteries using stress cardiac MRI.

This retrospective study evaluated prognostic value of stress cardiac MRI in 279 patients with myocardial infarction with nonobstructive coronary arteries (MINOCA) by stratifying them into four phenotype groups based on late gadolinium enhancement (LGE) and inducible ischemia. Major adverse cardiovascular events (MACE) risk differed across the LGE/ischemia phenotypes, indicating that stress CMR phenotype improves risk stratification beyond clinical presentation alone. Clinically, this supports using stress CMR (LGE plus inducible ischemia) to identify MINOCA patients at higher risk for adverse outcomes.

Tang L, Long Q, Zhao W et al. · Insights into imaging · (2026) · View on PubMed ↗ · Free PDF ↗

Rentrop collateral grade predicts myocardial viability in chronic total occlusion on cardiac magnetic resonance.

This Open Heart study investigated whether angiographic Rentrop collateral grade in patients with chronic total occlusion (CTO) predicts myocardial viability measured by quantitative cardiac magnetic resonance (CMR). Among 56 CTO patients undergoing CMR, viable myocardium was defined as ≤50% transmural scar on late gadolinium enhancement, and the study assessed myocardial blood flow (MBF) and scar burden within CTO territories. If Rentrop grading reliably tracks CMR viability, it could help clinicians estimate which CTO territories are likely salvageable and guide revascularization decisions.

Mehmood Z, Suresh P, Li R et al. · Open heart · (2026) · View on PubMed ↗ · Free PDF ↗

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CMR for cardiomyopathies (DCM/HCM/ATTR) and structural phenotyping

One-year worsening heart failure and myocardial T1 mapping in patients with wild-type transthyretin amyloid cardiomyopathy undergoing tafamidis treatment.

This retrospective study evaluated short-term responsiveness of myocardial T1 mapping on cardiac magnetic resonance (CMR) in 60 wild-type transthyretin amyloid cardiomyopathy (ATTR-CM) patients treated with tafamidis. After one year of tafamidis, worsening heart failure outcomes were assessed alongside changes in native myocardial T1 (T1native) and extracellular volume fraction (ECV), with biomarkers including high-sensitivity cardiac troponin T and NT-proBNP measured at baseline. The clinical significance is that myocardial T1 mapping may provide a CMR-based marker of treatment responsiveness and near-term prognosis in wild-type ATTR-CM.

Kitagawa T, Hamamoto K, Okamoto D et al. · International journal of cardiology. Heart & vasculature · (2026) · View on PubMed ↗ · Free PDF ↗

Diagnostic and prognostic value of T2 mapping in cardiac sarcoidosis.

This diagnostic/prognostic study enrolled 39 patients with cardiac sarcoidosis who underwent both 3T cardiac magnetic resonance (CMR) and 18F-FDG PET to define active inflammation and fibrosis. The key finding was that T2 mapping on CMR (a marker of myocardial inflammation) showed diagnostic and prognostic utility relative to PET findings, potentially offering a radiation- and contrast-sparing alternative for follow-up. The clinical significance is that CMR T2 mapping could reduce reliance on repeated 18F-FDG PET while still tracking inflammatory activity and outcomes in cardiac sarcoidosis.

Uno M, Kosuge H, Kobayashi M et al. · International journal of cardiology. Heart & vasculature · (2026) · View on PubMed ↗ · Free PDF ↗

Dilated cardiomyopathy vs. non-dilated left ventricular dysfunction: genotype-phenotype relationship and outcome.

This study investigated genotype–phenotype relationships and outcomes in patients with dilated cardiomyopathy (DCM) versus non-dilated left ventricular dysfunction (NDLVD), using comprehensive clinical assessment, genetic testing, and cardiac magnetic resonance (CMR) in individuals with left ventricular ejection fraction (LVEF) <57%. Patients were classified as DCM or NDLVD based on LV end-diastolic volume index thresholds, and the study found distinct genotype–phenotype patterns with different prognostic implications between groups. These findings support more precise genetic and CMR-based risk prediction for patients presenting with LV systolic dysfunction but differing remodeling phenotypes.

Bellisario I, Aimo A, Todiere G et al. · International journal of cardiology · (2026) · View on PubMed ↗

Microstructural disease and hypoperfusion in dilated cardiomyopathy underpin midwall septal fibrosis.

This prospective, multi-referral single-center CMR study compared dilated cardiomyopathy (DCM) patients with midwall septal fibrosis (MSF+) versus those without (MSF−), and against controls matched for age and sex, to determine whether MSF reflects distinct microstructural and microvascular abnormalities. The key finding was that MSF in DCM is underpinned by microstructural disease and myocardial hypoperfusion patterns detectable with advanced CMR. Clinically, identifying these mechanisms strengthens the rationale for targeting perfusion and microstructural injury pathways in DCM patients with MSF.

Chan FT, Coveney S, Zheng SL et al. · Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · (2026) · View on PubMed ↗ · Free PDF ↗

COVID-19 outcomes and persistent symptoms in patients with hypertrophic cardiomyopathy: association with pre-existing cardiovascular magnetic resonance phenotype.

This international HCM Registry study evaluated whether pre-existing cardiovascular magnetic resonance (CMR) phenotypes in 1,704 hypertrophic cardiomyopathy (HCM) participants predict COVID-19 outcomes and recovery after infection. Among 767 participants with reported COVID-19, baseline CMR features were tested for association with hospitalization and impaired recovery (≥3 months) using multivariable logistic regression. The findings aim to identify which CMR-defined HCM phenotypes confer higher vulnerability to worse COVID-19 outcomes, supporting risk stratification in HCM patients.

Singhal A, Appleby E, Agnel O et al. · Heart (British Cardiac Society) · (2026) · View on PubMed ↗

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Atrial fibrillation (AF) and atrial cardiomyopathy (including ablation planning)

Left atrial epicardial adipose tissue volume quantification by CMR aids identification of patients at low risk for left atrial cardiomyopathy.

This CMR study quantified left atrial epicardial adipose tissue (LA-EAT) volume in patients presenting for primary atrial fibrillation (AF) ablation to determine whether it predicts low risk for left atrial cardiomyopathy. The key finding was that LA-EAT volume was associated with the presence of low-voltage zones (LVZ) identified by invasive electroanatomic mapping, helping identify patients at lower risk. Clinically, LA-EAT quantification may refine AF ablation candidate selection by noninvasively estimating atrial cardiomyopathy burden.

Schmidt TR, Ulbrich S, Gaspar T et al. · Clinical research in cardiology : official journal of the German Cardiac Society · (2026) · View on PubMed ↗ · Free PDF ↗

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Pulmonary hypertension (PH) and right-heart hemodynamics

CMR-derived left ventricular pressure-volume loops enhance individualized assessment of disease severity and prognosis in pulmonary arterial hypertension in adults.

This study used cardiovascular magnetic resonance (CMR) to derive left ventricular (LV) pressure–volume (PV) loops and tested their prognostic value in 96 adult patients with pulmonary arterial hypertension (PAH) compared with 32 matched healthy controls. The key finding was that CMR-derived LV PV-loop parameters provided prognostic information for outcomes such as death or lung transplantation, reflecting LV underfilling and altered mechanics secondary to increased pulmonary vascular resistance. This supports PV-loop–based CMR as an individualized, noninvasive method to enhance disease severity assessment and risk prediction in adult PAH.

Castiglione A, Bergström E, Kjellström B et al. · Physiological reports · (2026) · View on PubMed ↗ · Free PDF ↗

Enhancing Intermediate-Risk Stratification in Pulmonary Hypertension: CMR-Derived Quantification of Right Ventricular-Arterial Coupling.

The study assessed whether CMR-derived right ventricular (RV)–arterial coupling quantified as stroke volume to end-systolic volume ratio (SV/ESV) improves prognostic stratification in pulmonary hypertension (PH) patients classified as intermediate-risk by the 2022 ESC/ERS four-strata model. The key finding was that SV/ESV-based quantification could reclassify intermediate-risk patients into intermediate-low and intermediate-high groups with different risks for clinical worsening (hospitalization for congestive heart failure or death). This is clinically significant because it refines risk stratification within the intermediate-risk category using CMR metrics that may guide management intensity.

Tian H, Wu Q, Wang Z et al. · Academic radiology · (2026) · View on PubMed ↗

End-diastolic forward flow (EDFF) after tetralogy of Fallot repair: Evolution of its role in management and prognosis.

This article reviewed the evolution of end-diastolic forward flow (EDFF) after tetralogy of Fallot (ToF) repair, focusing on how EDFF has been interpreted as a marker of restrictive RV physiology and its current understanding as a multifactorial hemodynamic phenomenon. The key finding is that EDFF is not a single, specific surrogate for myocardial stiffness, but instead reflects multiple interacting hemodynamic and imaging factors after ToF repair. This is significant because it informs how clinicians should interpret EDFF in prognosis and decision-making for repaired ToF patients.

Baneu P, van Dijk AP, Duijnhouwer AL et al. · International journal of cardiology. Congenital heart disease · (2026) · View on PubMed ↗ · Free PDF ↗

Multimodality imaging of patent ductus arteriosus with severe pulmonary hypertension following 3 pregnancies.

This radiology case report described multimodality imaging of a 46-year-old woman with severe pulmonary hypertension due to a previously unrecognized large patent ductus arteriosus (PDA) after three pregnancies. The key finding was that multimodal imaging plus right- and left-heart catheterization demonstrated systemic-level pulmonary vascular resistance with bi-directional shunting and right ventricular dilation/dysfunction. This is significant because it highlights the diagnostic value of multimodality imaging for adult PDA presenting with severe pulmonary hypertension.

Corsi D, Mousa A, Patel D et al. · Radiology case reports · (2026) · View on PubMed ↗ · Free PDF ↗

Flow Hemodynamics in Children with Tetralogy of Fallot: A Comparison Study of Cardiac Catheterization and Phase-Contrast MRI.

This study compared invasive cardiac catheterization using the Fick principle versus phase-contrast cardiac MRI (PC-MRI) for assessing pulmonary flow hemodynamics in 33 children with repaired tetralogy of Fallot (TOF). PC-MRI provided more direct measures of blood flow and regurgitant fraction, whereas Fick-based cardiac index estimates were potentially inaccurate due to assumptions about oxygen consumption and the presence of pulmonary regurgitation. These findings support PC-MRI as a more reliable noninvasive approach for lifelong pulmonary hemodynamic surveillance in pediatric TOF.

Berthusen AJ, Saucedo JG, Schäfer M et al. · Pediatric cardiology · (2026) · View on PubMed ↗

Prognostic value of pulmonary transit time by cardiovascular MRI in heart failure with preserved ejection fraction.

This prospective study assessed whether pulmonary transit time (PTT) measured by cardiovascular MRI independently predicts outcomes in heart failure with preserved ejection fraction (HFpEF). Adult HFpEF patients underwent comprehensive phenotyping including blood sampling, ECG, 6-minute walk testing, echocardiography, and multiparametric CMR to quantify PTT, and the investigators evaluated its prognostic value for adverse clinical outcomes. If PTT is independently predictive, it provides a non-invasive CMR marker of cardiopulmonary hemodynamics that can improve HFpEF risk stratification.

Shergill S, Dattani A, Kanagala P et al. · Heart (British Cardiac Society) · (2026) · View on PubMed ↗

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Valvular heart disease hemodynamics (TR/AR/diastolic flow)

The Effect of Aortic Regurgitation on Left Ventricular Flow Dynamics Assessed by 4D-Flow MRI.

This study assessed how aortic regurgitation (AR) alters left ventricular (LV) diastolic flow dynamics and viscous energy dissipation (VED) using 4D-flow MRI in patients with AR. The key finding was that 4D-flow MRI–derived flow metrics and VED quantify AR-related hemodynamic burden in the LV beyond conventional severity measures. These results support 4D-flow MRI as a more mechanistic, quantitative approach for grading AR severity and predicting LV impact via energy-loss characterization.

Abdallah W, Darwish A, Garcia J et al. · Annals of biomedical engineering · (2026) · View on PubMed ↗

Gender differences in clinical phenotype, right-heart remodelling and outcomes in severe tricuspid regurgitation: a cardiac magnetic resonance study.

This multicenter cardiac magnetic resonance (CMR) study investigated sex differences in clinical phenotype, right-heart remodeling, and all-cause mortality among patients with severe tricuspid regurgitation (TR) under medical therapy. The key finding was that women and men differed in right ventricular remodeling measures assessed by CMR and in mortality outcomes during follow-up, while patients undergoing tricuspid valve intervention were censored at the time of procedure. The clinical significance is that sex-specific differences in TR remodeling and prognosis may inform risk stratification and management decisions.

Hinojar R, Rodriguez Palomares J, Barreiro-Pérez M et al. · European heart journal. Cardiovascular Imaging · (2026) · 1 citations · View on PubMed ↗

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Cardio-oncology: cancer therapy cardiotoxicity surveillance and imaging

Cardiac Biomarkers and Multimodality Imaging in Surveillance During Oncologic Therapy: An Integrated Approach to Cardio-Oncology.

This narrative review synthesized evidence on how cardiac biomarkers and multimodality imaging are used during surveillance for cardiovascular toxicity in patients receiving oncologic therapies. The key finding was that integrating biomarkers with advanced imaging improves early detection of therapy-related cardiotoxicity across major cancer treatment classes (e.g., anthracyclines, HER2-targeted therapy, VEGF inhibitors, immune checkpoint inhibitors, and chest radiotherapy). Scientifically and clinically, it reinforces a structured cardio-oncology surveillance strategy to identify subclinical injury and guide timely intervention.

Agrawal SP, Lussier A, Patel DS et al. · Cardiology in review · (2026) · View on PubMed ↗

Prediction of Anthracycline-induced Cardiotoxicity Using Cardiac MRI Parameters: An Animal Study.

This preclinical animal study used 31 Sprague-Dawley rats treated with weekly intravenous doxorubicin (2 mg/kg) to up to 12 weeks to test whether cardiac MRI native T1 and extracellular volume fraction (ECV) predict early mortality. Cox regression showed that MRI parametric mapping variables were associated with early death risk, and histology was used to corroborate cardiotoxic injury. The results support using native T1/ECV as prognostic biomarkers for anthracycline-induced cardiotoxicity before overt clinical deterioration.

Kim NY, Park J, Park HS et al. · Radiology. Cardiothoracic imaging · (2026) · View on PubMed ↗

Real-world multi-institution analysis of tarlatamab in patients with small cell lung cancer.

This real-world multicenter retrospective analysis evaluated outcomes of tarlatamab in patients with small cell lung cancer (SCLC) who received at least one dose between 5/16/2024 and 6/15/2025 across three US institutions. The key finding was that “trial-ineligible” patients—defined by factors such as ECOG performance status ≥2 and prior grade ≥2 pneumonitis or interstitial lung disease—had real-world outcomes that differed from those expected in pivotal clinical trial eligibility populations. This is significant because it clarifies the effectiveness and safety of tarlatamab in broader, less-selected SCLC populations encountered in routine practice.

Cooper AJ, Liang J, McDonald S et al. · Lung cancer (Amsterdam, Netherlands) · (2026) · View on PubMed ↗ · Free PDF ↗

Development of Antibody-Drug Conjugates Targeting L1CAM to Treat Metastatic Cancer.

This preclinical translational study developed antibody-drug conjugates (ADCs) targeting L1 cell adhesion molecule (L1CAM) to eliminate drug-resistant metastatic cancer stem cells (MetSCs) in metastatic disease models. The key finding is that L1CAM-targeted ADCs can selectively address MetSCs expressing L1CAM, aiming to overcome chemotherapy resistance and prevent relapse. This supports L1CAM as a therapeutic target for ADC strategies against metastatic stem-cell–driven recurrence.

Park JS, Kenum C, He L et al. · Molecular cancer therapeutics · (2026) · 1 citations · View on PubMed ↗ · Free PDF ↗

Trastuzumab deruxtecan: An antibody-drug conjugates for non-small cell lung cancer.

This narrative review summarized evidence for trastuzumab deruxtecan (T-DXd), an antibody-drug conjugate, in non-small cell lung cancer (NSCLC) with HER2-mutant metastatic disease after prior systemic therapy. The key finding is that clinical trial and real-world evidence supports T-DXd’s efficacy and characterizes its safety profile and adverse event management in this population. The review consolidates practical guidance for using T-DXd in HER2-mutant metastatic NSCLC and highlights ongoing evidence needs.

Siddiqui N, Sravanthi G, Reddy KJK et al. · Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners · (2026) · View on PubMed ↗

Multimodality Cardiac Imaging and Multidisciplinary Collaboration in Monitoring Intracardiac Sarcoma Response to Immunotherapy.

This JACC Case Reports report describes multimodality cardiac imaging and multidisciplinary management of a 40-year-old man with intracardiac sarcoma causing right ventricular outflow tract obstruction who received immune checkpoint inhibitor (ICI) therapy. Cardiac MRI tissue characterization enabled a noninvasive diagnosis without endomyocardial biopsy, and serial echocardiography and other imaging were used to monitor response while accounting for the risk of immune-mediated pseudoprogression. The case is significant because it illustrates an imaging-guided strategy for safely tracking intracardiac tumor response to immunotherapy in a high-risk hemodynamic setting.

Kocx C, Geraghty L, Rolfe Z et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗

Machine Learning Model Using Pre-Cancer Therapy Cardiac Magnetic Resonance Images to Predict Cancer Therapy-Related Cardiac Dysfunction.

This prospective multicenter study developed a deep learning model using pre-treatment cardiac magnetic resonance (CMR) images to predict cancer therapy-related cardiac dysfunction (CTRCD) in women with HER2+ breast cancer receiving anthracyclines and trastuzumab. The model was trained to forecast CTRCD defined by CMR and was compared against clinical and conventional imaging models using repeated echocardiography and CMR at baseline, after anthracycline, and at frequent follow-up timepoints. Scientifically and clinically, it targets earlier identification of patients at risk for CTRCD from specific cardiotoxic regimens (anthracycline + trastuzumab) to enable timely intervention.

Yu C, Peikari M, Labib D et al. · JACC. Cardiovascular imaging · (2026) · View on PubMed ↗

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Machine learning & AI for cardiac imaging, reconstruction, and prediction

AI-based Histologic Heterogeneity of Microvascular Obstruction at Cardiac MRI for Predicting MACEs: A Multicenter Study.

This multicenter retrospective study developed an AI model that combines automated microvascular obstruction (MVO) segmentation with radiomic feature extraction to predict major adverse cardiovascular events (MACEs) in STEMI patients with MVO undergoing cardiac MRI. The key finding was that AI-derived heterogeneity features of microvascular injury improved MACE prediction compared with approaches that rely on manual or less informative MVO quantification. Clinically, this supports automated, imaging-based risk stratification after STEMI by capturing the spatial heterogeneity of microvascular damage.

Chen BH, Li SL, Xiang JY et al. · Radiology · (2026) · View on PubMed ↗

Interpretable machine learning models based on CMR radiomics for predicting left ventricular diastolic dysfunction in patients with metabolic-associated steatotic liver disease and type 2 diabetes mellitus.

This study developed interpretable machine learning models using cardiac magnetic resonance (CMR) radiomics plus clinical variables to predict left ventricular diastolic dysfunction (LVDD) in 175 patients with metabolic-associated steatotic liver disease (MASLD) and type 2 diabetes mellitus (T2DM). The key finding was that the radiomics-informed model improved LVDD risk prediction compared with clinical data alone while remaining interpretable. This is significant because it enables earlier identification of LVDD risk in MASLD/T2DM, potentially supporting proactive, personalized intervention.

Xia J, Leng S, Xu B et al. · Journal of diabetes investigation · (2026) · View on PubMed ↗ · Free PDF ↗

Incorporating modality-specific intensity prior as text prompt for multimodal myocardial pathology segmentation.

The study developed an intensity-guided multimodal myocardial pathology segmentation method (I-MMSeg) for cardiac magnetic resonance (CMR) images, using a multimodal large language model (e.g., GPT-4o) to generate modality-specific intensity priors in patients with myocardial infarction–related pathology. The key finding is that GPT-4o–generated priors capture relative intensity ordering across regions and boundary intensity characteristics, improving segmentation guidance beyond morphology/geometric priors. This is clinically significant because more accurate myocardial pathology delineation can strengthen CMR-based infarction risk assessment and treatment planning.

Fang D, Gu Y, Yu L et al. · Medical image analysis · (2026) · View on PubMed ↗

Automated assessment of right heart function by artificial intelligence: A systematic review and meta-analysis.

This systematic review and meta-analysis evaluated artificial intelligence (AI) models for automated assessment of right ventricular (RV) size and function, synthesizing diagnostic accuracy across included studies. Across pooled evidence, AI approaches showed performance metrics for predicting RV size/function, with the review also grading evidence quality and heterogeneity. The findings help determine whether AI-based RV quantification can reliably augment or replace traditional echocardiography in clinical practice.

Eini P, Serpoush H, Rezayee M et al. · European journal of radiology open · (2026) · 2 citations · View on PubMed ↗ · Free PDF ↗

Interpretable Semi-federated Learning for Multimodal Cardiac Imaging and Risk Stratification: A Privacy-Preserving Framework.

This study introduced PerFed-Cardio, an interpretable semi-federated learning (Semi-FL) framework for privacy-preserving multimodal cardiac imaging and risk stratification using imaging, physiological signals, and electronic health records (EHR). The key finding is that the semi-federated, personalized approach enables high-capacity nodes (e.g., hospitals) to train comprehensive models while edge devices (e.g., wearables) contribute without exposing raw data, maintaining interpretability. This provides a scalable method for real-time cardiovascular risk prediction across heterogeneous data sources while protecting patient privacy.

Liu X, Li S, Zhu Q et al. · Journal of imaging informatics in medicine · (2026) · 4 citations · View on PubMed ↗

Inter-AI Agreement in Measuring Cine MRI-Derived Cardiac Function and Motion Patterns: A Pilot Study.

This pilot study assessed inter-AI agreement for measuring cine MRI-derived cardiac function and motion patterns in 23 healthy volunteers using two automated heart analysis tools (heart deformation analysis, Trufistrain; and Circle CVI 42). The key finding was that AI-derived measurements of left and right ventricular end-diastolic volumes (LVEDV and RVEDV) and motion indices showed measurable agreement between tools, supporting feasibility of consistent automated quantification. Scientifically, this provides early evidence that different AI pipelines can produce concordant cardiac cine metrics, which is important for reproducibility and multi-tool validation.

Lin K, Sarnari R, Gordon DZ et al. · Journal of imaging informatics in medicine · (2026) · View on PubMed ↗

Enhancing patient-specific computational modeling of cardiac mechanics by leveraging high spatiotemporal resolution magnetic resonance imaging.

This study tested whether high spatiotemporal resolution free-breathing 4D cardiac MRI (AutoCMR; 30 volumetric frames per cardiac cycle at 1.6 mm isotropic resolution) plus cuff systolic and diastolic blood pressures improves patient-specific computational cardiac mechanics models. The key finding was that leveraging this richer imaging data improves non-invasive calibration and internal consistency of both 0D lumped-parameter and 3D finite element models. This is significant for advancing more accurate, clinically usable computational modeling for diagnosis, surgical planning, and device design.

Darayi M, Kara D, Le H et al. · Computer methods and programs in biomedicine · (2026) · View on PubMed ↗

Stratification of children with myocarditis using radiomics signatures in LGE cardiovascular MRI.

This study investigated whether radiomics features quantifying late gadolinium enhancement (LGE) texture and location can stratify pediatric myocarditis patients using LGE cardiovascular MRI. It compared radiomic features across resampling strategies using a digital phantom to address variability in patient size and imaging parameters, then applied non-negative matrix factorization (NMF) to derive LGE signatures for case stratification. If validated, these quantitative LGE radiomics signatures could improve risk stratification and move beyond qualitative LGE assessment in children with myocarditis.

Laube AP, Huellebrand M, Ter-Minassian L et al. · Computer methods and programs in biomedicine · (2026) · View on PubMed ↗

A composable multimodal framework for cine CMR-text-driven prediction of heart failure outcomes.

This study proposed and evaluated a composable multimodal machine-learning framework to predict heart failure outcomes using cine CMR text-driven inputs. The key finding was that combining multimodal components in a composable strategy enabled cine CMR–derived, text-informed prediction of heart failure outcomes more effectively than relying on a single modality (details truncated in the abstract). Clinically, such an approach could improve risk stratification and treatment optimization by extracting prognostic information from routine cine CMR data.

Chen J, Sun J, Wang X et al. · Physiological measurement · (2026) · View on PubMed ↗ · Free PDF ↗

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Advanced CMR acquisition/reconstruction methods (motion correction, acceleration, quantitative mapping)

Dual-Phase 3D Modified Dixon Steady-State MR Angiography in Pediatric Complex Congenital Heart Disease.

This retrospective single-center study evaluated dual-phase 3D modified Dixon (mDixon) steady-state MR angiography (MRA) in pediatric complex congenital heart disease to determine effects on phase-dependent image quality and vessel measurements. The key finding was that dual-phase acquisition with respiratory navigator gating improved or maintained vessel border delineation and enabled reliable systolic/diastolic vessel diameter measurements despite motion, flow, and susceptibility-related challenges. This supports dual-phase 3D mDixon steady-state MRA as a practical pediatric imaging technique for more accurate, phase-resolved vascular assessment in CHD.

Beissel LD, Hart C, Isaak A et al. · Radiology. Cardiothoracic imaging · (2026) · View on PubMed ↗

Grayscale-inverted bright-blood late gadolinium enhancement improves reader confidence in ischemic scar detection: a multivendor study.

This multivendor imaging study evaluated whether grayscale-inverted bright-blood late gadolinium enhancement (LGE) CMR improves ischemic scar detection accuracy and reader confidence compared with standard bright-blood LGE. In 120 patients scanned on GE, Philips, and Siemens 1.5T systems, grayscale inversion increased visual contrast for subendocardial infarcts where scar-to-blood contrast is limited, improving reader confidence and diagnostic performance. Clinically, this vendor-independent post-processing approach could make CMR scar assessment more reliable, particularly for subtle ischemic injury.

Károlyi M, Groenhoff L, Spiczak JV et al. · European journal of radiology · (2026) · View on PubMed ↗ · Free PDF ↗

Accelerated reconstruction of 5D free-running MRI with variable projection-augmented Lagrangian (VPAL).

This work studied variable projection augmented Lagrangian (VPAL) reconstruction for ferumoxytol-enhanced 5D free-running whole-heart cardiac MRI, comparing VPAL against alternating direction method of multipliers (ADMM) in terms of computation time and image quality. VPAL substantially reduced the hours-long iterative reconstruction burden associated with ADMM while maintaining image quality suitable for CTA-like whole-heart imaging. Faster in-line 5D CMR reconstruction could enable routine clinical use of ferumoxytol-enhanced whole-heart perfusion/angiographic imaging.

Yang Y, Naeem M, van Assen M et al. · Magnetic resonance imaging · (2026) · View on PubMed ↗ · Free PDF ↗

Simultaneous Multi-Slice Acceleration for Free-Breathing Motion Corrected Late Gadolinium Enhancement Imaging.

This study developed and evaluated an accelerated free-breathing motion-corrected and averaged late gadolinium enhancement (LGE) cardiac MRI protocol combining simultaneous multi-slice (SMS) bSSFP with GC-LOLA motion correction and phase-sensitive inversion recovery (PSIR) reconstruction. In 26 clinical cardiac MRI patients, the SMS-accelerated free-breathing PSIR-MoCo LGE protocol produced comparable or improved myocardial sharpness and scar-to-blood/healthy myocardium contrast-to-noise estimates relative to a non-SMS reference while enabling faster acquisition. Faster, motion-robust LGE imaging can improve feasibility of routine scar assessment under free-breathing conditions.

Kowalik GT, Kunze KP, Bosio F et al. · Magnetic resonance in medicine · (2026) · View on PubMed ↗ · Free PDF ↗

K-CC-MoCo: A Fast k-Space-Based Respiratory Motion Correction for Highly Accelerated First-Pass Perfusion Cardiovascular MR.

This work studied K-CC-MoCo, a k-space-only inter-frame rigid respiratory motion correction method for highly accelerated first-pass perfusion cardiovascular MR (FPP-CMR) acquired during free breathing. By estimating and correcting respiratory motion directly in k-space, the method avoids the need for an initial image-domain reconstruction that can limit compatibility with model-based or deep learning reconstructions. This approach supports high-quality perfusion imaging from highly accelerated acquisitions while preserving the ability to use advanced reconstruction pipelines.

Moya-Sáez E, Menchón-Lara RM, Sánchez-González J et al. · Magnetic resonance in medicine · (2026) · View on PubMed ↗ · Free PDF ↗

Rosette Cardiac MR Fingerprinting for Simultaneous T1, T2, T 2 * , and Fat Fraction Mapping Using a Multi-Echo Deep Image Prior Reconstruction.

This study developed “rosette” cardiac MR fingerprinting (cMRF) to simultaneously map T1, T2, T2*, and fat fraction using a multi-echo acquisition reconstructed with a deep image prior framework. Using a 2D single-breathhold ECG-gated rosette trajectory to sensitize signals to T1/T2/T2* and off-resonance effects, the deep image prior reconstruction enabled parameter map generation from a single scan. Multi-parameter quantitative mapping with reduced scan burden could improve clinical assessment of diverse myocardial diseases.

Cummings E, Cruz G, Richardson J et al. · Magnetic resonance in medicine · (2026) · View on PubMed ↗ · Free PDF ↗

MoCo + ROVir: Synergy Between Respiratory Motion Compensation and Cardiac Receive Region Focusing for Cardiac MRI.

This study evaluated MoCo + ROVir, a synergistic reconstruction strategy combining rigid respiratory motion compensation (MoCo) with cardiac receive region focusing using region-optimized virtual coils (ROVir) for cardiac MRI. In retrospective pediatric data (N=24), the proposed MoCo + ROVir-LRT reconstruction was designed to prioritize cardiac motion representation over respiratory motion within a low-rank tensor (LRT) framework, reducing artifacts and improving motion modeling. The method could enhance image quality and reliability for cardiac- and respiratory-resolved pediatric cardiac MRI acquisitions.

Hu Z, Lee HL, Cao T et al. · Magnetic resonance in medicine · (2026) · View on PubMed ↗ · Free PDF ↗

Clinical evaluation of accelerated breath-held and free-breathing cine cardiac MRI using model-based deep learning reconstruction (SonicDL) in children and young adults.

This clinical evaluation study tested a commercially available model-based deep learning reconstruction method (SonicDL) for accelerated cine cardiac MRI in children and young adults. It compared accelerated breath-held and free-breathing bSSFP cine acquisitions across multiple acceleration levels, assessing diagnostic image quality, ventricular volumetric accuracy, and scan-time reduction. The work supports DL-accelerated cine MRI as a practical approach to reduce breath-hold burden while maintaining clinically acceptable ventricular measurements.

Kocaoglu M, Ta H, Lang SM et al. · Pediatric radiology · (2026) · View on PubMed ↗

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Noninvasive coronary assessment & microvascular dysfunction (CMD/MyoTT/iMBV)

A Case of the Uncommon Cause of Chronic Coronary Syndrome: Coronary Fistula and Coronary Stenosis, Which One to Intervene?

This case report evaluated a patient with chronic coronary syndrome (CCS) who had both a coronary artery fistula and a mid-left anterior descending (mid-LAD) coronary stenosis, using comprehensive diagnostic testing before, during, and after intervention. The workup identified a nonsignificant 50% mid-LAD stenosis alongside an unexpectedly high-flow LAD-to-main pulmonary artery fistula, guiding which lesion to treat. The report highlights the need for detailed physiologic and imaging assessment when multiple coronary mechanisms coexist in CCS.

Sinurat MRMP, Taofan T, Tobing DPL et al. · The International journal of angiology : official publication of the International College of Angiology, Inc · (2026) · View on PubMed ↗ · Free PDF ↗

Diagnostic yield of second-line functional imaging after an abnormal coronary computed tomography angiography: an individual patient-data meta-analysis.

This individual patient-data meta-analysis studied diagnostic yield of second-line functional imaging after abnormal coronary computed tomography angiography (CCTA) in 1410 patients (mean age ~62; 67% male) with ≥50% diameter stenosis. The key finding was that the diagnostic performance of second-line tests—dobutamine stress echocardiography, SPECT, CMR, and/or PET—should be interpreted against invasive reference standards using fractional flow reserve (FFR), informing which modality best rules in/out ischemia. This is clinically significant because it supports evidence-based selection of the most appropriate functional imaging test after an abnormal CCTA.

Rasmussen LD, Hoek R, Westra J et al. · European heart journal. Cardiovascular Imaging · (2026) · 1 citations · View on PubMed ↗

Non-contrast multimodal cardiac MRI for predicting coronary microvascular dysfunction in patients with hypertrophic cardiomyopathy.

This study developed a non-contrast multimodal cardiac MRI radiomics model to predict coronary microvascular dysfunction (CMD) in patients with hypertrophic cardiomyopathy (HCM), aiming to reduce reliance on contrast-enhanced CMR. Using 290 HCM patients stratified by CMD status and split into training and test sets (8:2), the authors extracted radiomics features from end-diastolic four-chamber and end-diastolic short-axis views and used logistic regression to identify predictive imaging features. Scientifically and clinically, a validated non-contrast radiomics approach could enable more practical CMD screening in HCM, especially when contrast use is undesirable.

Li J, Zhu L, Liu Y et al. · Magnetic resonance imaging · (2026) · View on PubMed ↗

Myocardial transit time mapping by CMR: A novel potential parameter of microcirculatory dysfunction in hypertrophic cardiomyopathy with and without atrial fibrillation.

This research assessed myocardial transit time (MyoTT) by cardiovascular magnetic resonance (CMR) as a marker of coronary microvascular dysfunction in 50 patients with hypertrophic cardiomyopathy (HCM) with and without atrial fibrillation (AF) and 50 healthy controls. MyoTT (along with native T1, extracellular volume [ECV], and myocardial strain) distinguished HCM from controls and helped characterize AF status within HCM. The study suggests CMR-derived MyoTT as a noninvasive imaging parameter for microcirculatory dysfunction and risk-relevant phenotyping in HCM.

Yang J, Cheng Y, Yang J et al. · European journal of radiology open · (2026) · View on PubMed ↗ · Free PDF ↗

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Inflammation and immunomodulation in cardiovascular disease

Clinical Features, Treatment, and Outcomes of Sintilimab-Induced Myocarditis.

This retrospective study analyzed 34 reported cases of sintilimab-induced myocarditis to characterize clinical features, timing, and outcomes after immune checkpoint inhibitor exposure. Myocarditis onset occurred 1–120 days post-treatment (median 21 days), with common symptoms including dyspnea and chest tightness, supporting a typical immune-related adverse event timeline. Clinically, the findings help inform diagnosis and management strategies for myocarditis associated with sintilimab (an anti–PD-1 therapy).

Liu M, Sun W, Pan Y et al. · Journal of immunotherapy (Hagerstown, Md. : 1997) · (2026) · View on PubMed ↗

Effect of Interleukin-6 Receptor Inhibition by Tocilizumab on Platelet Activation and Markers of Thrombus Formation: A Substudy of the ASSAIL-MI Trial.

In a substudy of the ASSAIL-MI trial, this study tested whether IL-6 receptor inhibition with tocilizumab alters platelet activation and thrombus-formation biomarkers in patients with myocardial infarction. The key finding was that blocking IL-6R with tocilizumab changed circulating soluble markers of platelet activation (e.g., P-selectin and sCD40L) and coagulation/thrombus-related factors (including tissue factor, TFPI, PAI-1, and D-dimer). This is clinically significant because it links anti-inflammatory therapy (tocilizumab) to measurable effects on coagulation and platelet activation pathways relevant to post-MI thrombosis.

Ueland T, Dahl TB, Michelsen A et al. · Arteriosclerosis, thrombosis, and vascular biology · (2026) · View on PubMed ↗

Deciphering Leukocyte Subpopulation Contributions to Ventricle Remodeling and Neuroinflammation After Myocardial Infarction Using Total-Body Molecular Imaging.

This preclinical study examined how macrophages and neutrophils contribute to ventricle remodeling and concurrent neuroinflammation after myocardial infarction (MI) in C57BL/6N mice using total-body PET molecular imaging. Permanent coronary artery ligation induced MI, and immune modulation was performed by depleting peripheral macrophages with clodronate-loaded liposomes and inhibiting neutrophils with a neutralizing anti-Ly6G antibody, enabling assessment of how each population affects PET-detected neuroinflammatory signals. The work is significant because it links specific leukocyte subpopulations to both cardiac remodeling and brain inflammation, informing mechanisms and potential targets to reduce post-MI cognitive risk.

Lolatte K, Hess A, Willmann M et al. · Journal of nuclear medicine : official publication, Society of Nuclear Medicine · (2026) · 2 citations · View on PubMed ↗

Molecular imaging of lymphatic organs provides prognostic value after acute myocardial infarction.

This prospective trial studied whether molecular imaging of lymphatic organs after acute myocardial infarction (AMI) predicts functional recovery, using 68Ga-PentixaFor PET targeting CXCR4 on leukocytes. In 41 timely reperfused ST-elevation AMI patients, baseline uptake in remote lymphatic organs (spleen, bone marrow, and heart-draining lymph nodes) provided prognostic information for subsequent left ventricular ejection fraction (LV EF) recovery. The work is clinically significant because it suggests a whole-body/lymphatic inflammation imaging biomarker to stratify patients by recovery risk after AMI.

Reiter T, Dörrler AL, Hasenauer N et al. · European journal of nuclear medicine and molecular imaging · (2026) · 1 citations · View on PubMed ↗ · Free PDF ↗

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Genetics, omics, and Mendelian randomization for cardiovascular targets

Integrative omics analysis incorporating cardiovascular magnetic resonance imaging pinpoints potentially druggable plasma proteins for cardiovascular diseases.

This study used integrative omics in the ARIC cohort, combining protein quantitative trait loci (pQTL) for plasma proteins with genome-wide association studies of 19 cardiovascular diseases and 82 cardiovascular magnetic resonance (CMR) traits to identify potentially druggable plasma proteins. The key finding was that linking CMR-associated genetic signals to plasma protein pQTLs via proteome-wide association study (PWAS) and Mendelian randomization highlighted specific plasma proteins as candidate therapeutic targets for cardiovascular disease. This approach is significant because it prioritizes druggable circulating proteins using CMR phenotypes, potentially accelerating target discovery for CVD beyond traditional risk factors.

Gong W, Guo P, Liu L et al. · Life metabolism · (2026) · View on PubMed ↗ · Free PDF ↗

Generation of three heterozygous and two homozygous hiPSC lines from a CPVT associated mutation RYR2_p.G357S from a large family of the Canary Islands.

This study generated induced pluripotent stem cell (hiPSC) lines from skin fibroblasts of carriers in a Canary Islands family with catecholaminergic polymorphic ventricular tachycardia (CPVT) due to an RYR2 mutation (RYR2_p.G357S; also described as RYR2_c.G1069A/p.G357S). Using non-integrative episomal plasmids, the authors produced three heterozygous and two homozygous hiPSC lines that showed normal karyotypes, pluripotency marker expression, and differentiation into cells of all three germ layers. These patient-specific hiPSC resources are significant for modeling CPVT mechanisms and enabling gene- and drug-based studies of RYR2-linked arrhythmogenesis.

Carreras D, Martínez-Moreno R, Selga E et al. · Stem cell research · (2026) · View on PubMed ↗ · Free PDF ↗

Clinical Phenotypes in Hypertension: A Data-Driven Approach to Risk Stratification.

This data-driven study used unsupervised machine learning (k-means clustering) in 14,840 UK Biobank participants with diagnosed hypertension and cardiovascular magnetic resonance (CMR) imaging to identify clinical phenotypes and relate them to imaging features and adverse outcomes. The analysis derived distinct hypertension risk profiles and evaluated how cardiac imaging mediated associations with outcomes. The work advances phenotype-based risk stratification in hypertension by linking machine-learned clinical clusters to CMR-defined cardiac changes.

Rauseo E, Salih AM, Cooper J et al. · Hypertension (Dallas, Tex. : 1979) · (2026) · 1 citations · View on PubMed ↗ · Free PDF ↗

Multiple 4q25 risk variants impair calcium homeostasis and compromise left atrial function.

This study tested how atrial fibrillation (AF) risk single-nucleotide polymorphisms (SNPs) at chromosome 4q25 (rs1448818, rs2200733, rs10033464) affect calcium homeostasis and left atrial function in 391,008 UK Biobank participants. The three 4q25 risk alleles increased incident AF over 10 years in a dose-dependent manner, with additive genetic and clinical risk, and the SNPs showed differential effects consistent with impaired calcium handling that compromises left atrial performance. These findings support SNP-specific mechanisms linking 4q25 variants to AF pathophysiology and suggest calcium-homeostasis pathways as potential therapeutic targets.

Jiménez-Sábado V, Tarifa C, Vad OB et al. · Cardiovascular research · (2026) · View on PubMed ↗ · Free PDF ↗

C-X-C motif chemokine ligands (CXCL1/CXCL9) in inflammatory pathways underlying epilepsy-related ventricular remodeling: a mendelian randomization study.

Using a two-step Mendelian randomization design, this study assessed whether genetically predicted epilepsy (including generalized and focal epilepsy) causally relates to epilepsy-related ventricular remodeling and whether plasma inflammatory proteins mediate these effects. The analysis tested 82 cardiac traits (76 cardiac MRI-derived phenotypes plus 6 ECG traits) as outcomes and used 91 plasma inflammatory proteins to evaluate inflammation as a genetic mediator. Scientifically, it aims to clarify causal pathways from epilepsy to cardiac structural/functional changes via specific inflammatory chemokine ligands (CXCL1/CXCL9) and related immune mechanisms.

Wang L, Liu G, Wang Y et al. · Acta neurologica Belgica · (2026) · View on PubMed ↗

Spatial and spectrotemporal features of noise alter female responses to costly male signals in Cope’s gray treefrog (Hyla chrysoscelis).

This behavioral neuroethology study examined how spatial release from masking (SRM) and comodulation masking release (CMR) alter female mate choice for energetically costly male calls in Cope’s gray treefrog (Hyla chrysoscelis). In two-alternative phonotaxis tests, females’ response probability, chosen male calling effort, and response latency were measured across noise treatments with different spatial and spectrotemporal noise properties. The results show how noise structure can bias sexual selection by changing the ability of females to maintain preferences for costly signals under acoustic interference.

Ward JL, Lee N, Kalra L et al. · Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · (2026) · View on PubMed ↗ · Free PDF ↗

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Clinical trials and therapeutics (cardiovascular drugs and interventional strategies)

Open-Irrigated Helical Radiofrequency Septal Ablation for Obstructive Hypertrophic Cardiomyopathy.

This case report evaluated open-irrigated helical radiofrequency septal ablation using a novel dedicated catheter via subclavian venous access in a 60-year-old man with drug-refractory obstructive hypertrophic cardiomyopathy (oHCM). The provoked LV outflow tract gradient fell from 130 to 30 mm Hg immediately and remained improved at 12 months, with 6-month cardiac MRI showing septal fibrosis and no procedural or follow-up complications. The report suggests this open-irrigated helical RF technique is feasible and effective for septal reduction in oHCM with sustained hemodynamic and imaging response.

Sun Y, Zhou X, Zhang M et al. · JACC. Case reports · (2026) · View on PubMed ↗

Arteriovenous fistula creation results in cardiac dysfunction and remodeling in a uremic pig model.

This study used a uremic pig model of chronic kidney disease induced by renal embolization to examine cardiovascular changes after arteriovenous fistula (AVF) creation, with percutaneous transluminal angioplasty (PTA) as a supportive intervention. AVF creation led to cardiac dysfunction and remodeling, consistent with maladaptive hemodynamic compensation in uremia. These findings establish a large-animal mechanistic platform for testing strategies to prevent AVF-associated cardiac injury in end-stage kidney disease patients.

Kane J, Singh PG, Kilari S et al. · American journal of physiology. Renal physiology · (2026) · View on PubMed ↗

Time trends in ICD recommendations and predictors of device activation hypertrophic cardiomyopathy: a real-world cohort study.

This real-world cohort study examined time trends in implantable cardioverter-defibrillator (ICD) recommendations and predictors of device activation in 52 hypertrophic cardiomyopathy (HCM) patients receiving primary-prevention ICDs between 2014 and 2024. The key finding was that evolving ESC guideline criteria changed real-world ICD eligibility and was associated with differences in subsequent event detection/activation patterns. The scientific significance is that it clarifies how guideline expansion for primary prevention translates into actual ICD performance and risk detection in contemporary HCM practice.

Marques Antunes M, Carvalheiro R, Cardoso I et al. · International journal of cardiology. Heart & vasculature · (2026) · View on PubMed ↗ · Free PDF ↗

Low-dose ventricular radiotherapy in wild-type transthyretin cardiac amyloidosis: a prospective, first-in-human, exploratory clinical trial.

This first-in-human prospective exploratory trial studied low-dose ventricular radiotherapy (LD-RT) at 10 Gy in 5 daily fractions in patients with wild-type transthyretin cardiac amyloidosis (ATTRwt-CA). The key finding was that treatment feasibility was assessed using 18F-Flutemetamol amyloid PET (septal and lateral LV tissue-to-background ratio) and CMR measures (extracellular volume and T1 mapping) at baseline and 12 weeks to detect changes in cardiac amyloid burden. This is clinically significant because it tests whether targeted radiotherapy can reduce myocardial amyloid deposition in ATTRwt-CA, potentially expanding therapeutic options beyond standard anti-amyloid strategies.

Guijarro D, Massie E, Zilli T et al. · International journal of cardiology. Heart & vasculature · (2026) · View on PubMed ↗ · Free PDF ↗

A high-fat diet nutritional intervention reprograms cardiac metabolism and improves systolic function in a pig model of heart failure with reduced ejection fraction.

This study investigated whether a high-fat diet (20% lard supplementation) can therapeutically reprogram cardiac metabolism and improve systolic function in a pig model of heart failure with reduced ejection fraction (HFrEF) created by progressive coronary artery stenosis. After two months, high-fat diet intervention improved systolic function and shifted myocardial metabolism away from the HFrEF-associated fatty-acid-to-glucose metabolic switch (increased myocardial glucose uptake). These findings support dietary metabolic reprogramming as a potential, non-pharmacologic strategy to modify disease biology and functional outcomes in HFrEF.

Galán-Arriola C, Pérez-Camargo D, Ferrarini A et al. · Basic research in cardiology · (2026) · View on PubMed ↗ · Free PDF ↗

Three-Hour Infusion of Methotrexate at 3 g/m2 With or Without Intrathecal Chemotherapy Significantly Reduces CNS Relapses and Improves Survival in Patients With Large B-Cell Lymphomas at Increased CNS Risk.

This clinical study investigated a pharmacokinetic-informed, CNS-directed high-dose methotrexate (HD-MTX) regimen—3 g/m2 infused over 3 hours with a preceding bolus, with or without intrathecal chemotherapy—in 336 large B-cell lymphoma (LBCL) patients who achieved complete metabolic response on CMR after R-CHOP/derivatives. Using updated CNS risk criteria (e.g., CNS-IPI ≥4 or ≥3 extranodal sites), the protocol was associated with significantly reduced CNS relapses and improved survival. The findings support a dosing-schedule–optimized HD-MTX strategy as an effective approach to prevent CNS recurrence in LBCL patients at increased CNS risk.

Ferreri AJM, Erbella F, Angelillo P et al. · American journal of hematology · (2026) · View on PubMed ↗

SGLT2 inhibitors therapy in patients with acute Takotsubo syndrome.

This comparative study assessed the safety, tolerability, and effects on myocardial recovery and inflammation of SGLT2 inhibitors in patients with acute Takotsubo syndrome (TTS). Among 22 SGLT2-treated TTS patients (dapagliflozin n=13; empagliflozin n=9) matched 1:2 to 44 untreated patients, all underwent cardiac MRI with T2 mapping within 7 days of admission to evaluate recovery and inflammatory changes. The results are clinically important because they address whether SGLT2 inhibitors—approved for heart failure—may improve outcomes in acute TTS, a population with limited evidence.

Arcari L, Camastra G, Sclafani M et al. · International journal of cardiology · (2026) · 1 citations · View on PubMed ↗

Canagliflozin attenuates CMR-quantified myocardial fibrosis in individuals with type 2 diabetes mellitus at high cardiovascular risk: a randomised open-label controlled trial.

This randomized open-label controlled trial evaluated whether canagliflozin (an SGLT2 inhibitor) attenuates CMR-quantified myocardial fibrosis and affects cardiac structure/function and microcirculation in 45 high-cardiovascular-risk adults with type 2 diabetes and preserved/mildly reduced LVEF (>50%). Canagliflozin treatment reduced myocardial fibrosis measures quantified by CMR compared with control, alongside favorable changes in relevant cardiac and microcirculatory parameters. The results strengthen the mechanistic evidence that SGLT2 inhibition can provide cardiovascular protection in high-risk type 2 diabetes beyond glycemic control.

Yan H, Liu J, Zhang Z et al. · Diabetologia · (2026) · View on PubMed ↗ · Free PDF ↗

Efficacy of low dose colchicine on left ventricular hypertrophy in patients with coronary artery disease: A randomized controlled trial.

This randomized controlled trial studied low-dose colchicine (0.6 mg daily) versus placebo in 66 patients with coronary artery disease (CAD), left ventricular hypertrophy (LVH), and controlled blood pressure, assessing effects over 48 weeks. Colchicine reduced left ventricular mass index (LVMI) measured by cardiac magnetic resonance imaging compared with placebo (primary endpoint). These findings support an anti-inflammatory strategy using colchicine to target LVH progression in CAD patients, potentially lowering downstream cardiovascular risk.

Chichareon P, Suwannanon R, Thungthienthong M et al. · British journal of clinical pharmacology · (2026) · 3 citations · View on PubMed ↗

Radiation induces diffuse extracellular remodeling of healthy myocardium in a dose- and time-dependent manner without a dense ablative effect.

This preclinical study examined structural and electrophysiological effects of cardiac stereotactic body radiotherapy (cSBRT) in eight healthy canines by delivering photon radiation doses up to 50 Gy and longitudinally tracking lesion formation with cardiac MRI and histology. The key finding was that radiation caused diffuse extracellular remodeling of healthy myocardium in a dose- and time-dependent manner without a dense, sharply ablative lesion effect. This is significant for optimizing cSBRT parameters for ventricular tachycardia by clarifying that therapeutic effects may involve widespread remodeling rather than focal ablation.

Paccione EN, Kwan E, Bergquist JA et al. · Heart rhythm · (2026) · 2 citations · View on PubMed ↗ · Free PDF ↗

Impact of a 12-week high-intensity interval training intervention on cardiac structure and function after COVID-19 at 12-month follow-up.

This randomized controlled trial studied whether a 12-week supervised high-intensity interval training (HIIT) program (4×4 min, three times weekly) versus standard care affects cardiac structure and function at 12-month follow-up in patients previously hospitalized for COVID-19. The key finding was that HIIT had measurable effects on cardiac magnetic resonance outcomes, including left ventricular mass (LVM), along with pulmonary diffusing capacity, symptom severity, and functional capacity at follow-up. Clinically, it suggests that structured exercise rehabilitation after COVID-19 may provide longer-term benefits for cardiac remodeling and cardiopulmonary function.

Rasmussen IE, Løk M, Durrer CG et al. · Experimental physiology · (2026) · 2 citations · View on PubMed ↗ · Free PDF ↗

Repurposing Empagliflozin for Duchenne Muscular Dystrophy-Associated Cardiomyopathy: Protocol for a Pharmacokinetics, Safety and Proof-of-Concept Trial in Children.

This protocol describes a single-arm, open-label phase 2 pharmacokinetics, safety, and proof-of-concept trial repurposing empagliflozin for Duchenne muscular dystrophy (DMD)-associated cardiomyopathy in children. The study will evaluate empagliflozin pharmacokinetics, ease-of-swallow, safety, and exploratory efficacy markers, with efficacy assessed alongside potential cardiac outcomes. If successful, it could establish a feasible and potentially disease-modifying therapy pathway for pediatric DMD cardiomyopathy using an SGLT2 inhibitor.

Lava SAG, Laurence C, Mallory J et al. · Cardiology and therapy · (2026) · View on PubMed ↗ · Free PDF ↗

Nivolumab with or without vinblastine for first-line treatment of elderly patients with Hodgkin lymphoma and coexisting medical conditions: the Niviniho phase II Lysa study.

This phase II LYSA NIVINIHO trial studied first-line nivolumab with or without vinblastine in treatment-naive elderly Hodgkin lymphoma patients aged ≥61 years with comorbidities that contraindicated standard chemotherapy. The study used nivolumab induction followed by consolidation with nivolumab alone for early complete metabolic response or nivolumab plus vinblastine for stable/partial response, with the primary endpoint being complete metabolic response (CMR) at end of treatment. If effective, this regimen could provide a less toxic, immune-based alternative for high-risk older HL patients who cannot tolerate conventional chemotherapy.

Lazarovici J, Amorim S, Bouabdallah K et al. · Haematologica · (2026) · View on PubMed ↗ · Free PDF ↗

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Congenital heart disease and pediatric cardiology imaging/outcomes

Navigating Mechanical Support in Cardiogenic Shock With Arterial Hypoplasia: Lessons From Arterial Tortuosity Syndrome.

This report described management challenges in a 19-year-old man with arterial tortuosity syndrome (ATS) presenting with cardioembolic stroke and rapidly evolving cardiogenic shock. The key finding was that severe arterial hypoplasia and extreme tortuosity (iliofemoral arteries 3 mm, ascending aorta 19 mm, thoracic aorta) made mechanical thrombectomy and peripheral VA-ECMO technically unfeasible despite multimodality imaging (cranial CTA, aortic angiography, and cardiac MRI). The case highlights how ATS anatomy can dictate feasibility of standard mechanical support strategies and underscores the need for imaging-guided planning in congenital arterial disorders.

Lara-García A, Caro-Codón J, Canales L et al. · Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions · (2026) · View on PubMed ↗

The Role of Multimodality Imaging in the Evaluation of Heart Failure and Surgical Transplant Planning of Patients with Adult Congenital Heart Disease.

This review summarized the role of multimodality cardiac imaging in evaluating heart failure and guiding surgical transplant planning in adults with congenital heart disease (ACHD). The key finding was that longitudinal, protocol-tailored imaging at expert centers improves identification of patients who need evaluation for advanced therapies and clarifies residual lesions and ventricular complications. Clinically, it supports guideline-based surveillance and modality selection to optimize transplant and advanced-therapy decision-making in ACHD.

Duarte VE, Rajpal S · Cardiac electrophysiology clinics · (2026) · View on PubMed ↗

Multi-organ infarctions secondary to a cardiac papillary fibroelastoma in early childhood.

This pediatric case report described a 4-year-old girl presenting with acute stroke and renal infarction, in whom transthoracic echocardiography and cardiac MRI identified a cardiac papillary fibroelastoma (CPFE). Surgical resection confirmed CPFE on histopathology, linking the tumor to multi-organ embolic events. The report emphasizes that CPFE—though rare in early childhood—should be considered in children with embolic stroke plus a cardiac mass.

Alfares F, Alghamdi M, Alkanhal A et al. · Indian journal of thoracic and cardiovascular surgery · (2026) · View on PubMed ↗ · Free PDF ↗

Ferumoxytol-Enhanced Myocardial T1 Tracking Using a Hybrid 2D/3D Steady-State MRI Sequence Captures Cyclic Intramyocardial Blood Volume Dynamics.

This feasibility study developed a ferumoxytol-enhanced (FE) “T1 tracking” hybrid 2D/3D steady-state cardiac MRI sequence to measure cyclic intramyocardial blood volume (iMBV) dynamics from systole to diastole. The technique enabled detection of systolic-to-diastolic iMBV changes on clinical MRI scanners without vasodilator stress, supporting its use as a marker of coronary microcirculation. If validated clinically, this approach could improve noninvasive detection of coronary artery disease by capturing cyclic microvascular blood volume behavior.

Unal HB, Zeynali S, Ahmed A et al. · NMR in biomedicine · (2026) · View on PubMed ↗ · Free PDF ↗

The role of advanced imaging in the diagnosis and management of scimitar syndrome in pediatric patients.

This imaging-focused review summarized how advanced imaging with cardiac CT and cardiovascular MRI (CMR) characterizes scimitar syndrome in pediatric patients and links variants to management. It describes the hallmark anatomy—partial/total anomalous right pulmonary venous drainage to the hepatic vein/IVC with associated right lung and pulmonary artery hypoplasia and systemic collaterals—and discusses treatment options such as surgical rerouting or resection. The review is clinically significant because it guides selection and interpretation of imaging findings that determine intervention planning in this rare congenital cardiopulmonary disorder.

Nguyen TVN, Emral HG, Voges I et al. · International journal of cardiology. Congenital heart disease · (2026) · View on PubMed ↗ · Free PDF ↗

The Rapid Long-axis Strain-based Prognostic Models Evaluate Composite Adverse Events for Asymptomatic Dextro-Transposition of the Great Arteries Patients after the Switch Operation.

This study evaluated biventricular strain and rapid long-axis strain (RLAS) to detect impaired mechanics and to build strain-based prognostic models for composite adverse events in asymptomatic dextro-transposition of the great arteries (d-TGA) patients after arterial switch operation (ASO). The key finding was that rapid long-axis strain–based prognostic modeling improved identification of patients at risk for long-term composite adverse events compared with approaches relying on conventional strain measures alone. This is significant for scientific risk stratification because it supports earlier, more precise selection of high-risk ASO patients using CMR-derived mechanical biomarkers.

Hu L, Guo C, Liu X et al. · Academic radiology · (2026) · View on PubMed ↗

Hypoplastic Left Heart Syndrome in U.S. Children: A 20-Year Look at Lives Lost and Gaps That Remain.

This population-based analysis examined hypoplastic left heart syndrome (HLHS)–related mortality in U.S. children using CDC WONDER death certificate data from 1999 to 2020. The study quantified age-adjusted and crude mortality trends stratified by year, age, sex, race, urbanization, state, and census region. The results identify persistent gaps in HLHS outcomes and inform where improvements in congenital heart disease care and access may be needed.

Siddiqi AK, Maniya MT, Ali KM et al. · Pediatric cardiology · (2026) · View on PubMed ↗

Coronary-Sparing Resection of a Pediatric Left Ventricular Fibroma Involving the Left Circumflex Artery: Six-Year Follow-Up.

This case report described surgical management of a 3-month-old female with a large intramyocardial left ventricular fibroma involving the left circumflex coronary artery, with six-year follow-up. Using multimodality imaging including cardiac MRI and coronary angiography for planning, surgeons performed partial tumor resection with mitral valvuloplasty at 23 months while preserving the intratumoral left circumflex artery. The long-term outcome highlights feasibility of coronary-sparing resection for pediatric LV fibromas when the tumor traverses a major coronary artery.

Lopes MS, Amaral ME, Francisco A et al. · World journal for pediatric & congenital heart surgery · (2026) · View on PubMed ↗

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Non-cardiac public health/biomedical topics (cancer mortality, neuro/behavioral, etc.)

A rapid phage-free platform for antigen-specific VNAR screening with BATCH system.

This methods paper developed a phage-free bacterial two-hybrid screening platform (BATCH) for antigen-specific shark-derived VNAR discovery using a Cre recombinase-immunized Chiloscyllium plagiosum spleen cDNA library (~10^8 diversity). Screening in BTH101 cells against pKT25c-Cre using dual lacZ and chloramphenicol resistance (CmR) readouts identified two unique VNAR binders (VNAR1a and VNAR1b). The platform provides a rapid alternative to phage display for generating VNARs against cryptic epitopes, expanding antibody discovery toolkits.

Tang W, Hu J, Zhu Y et al. · Protein science : a publication of the Protein Society · (2026) · View on PubMed ↗ · Free PDF ↗

Forecasting mortality and decomposition analysis for cancer deaths in Egypt (2014-2030).

This study analyzed time trends and drivers of cancer mortality in Egypt using national vital registration data for 19 cancer types from 2014–2023, forecasting through 2030 with a hybrid ARIMA–ETS model. The key finding was that projected cancer deaths through 2030 were shaped by contributions from population growth, population aging, and age-specific mortality rates, with an overall increase in mortality burden reported in the results. This is significant for public health planning because it quantifies which demographic and epidemiologic components are driving future cancer mortality in Egypt.

Elshishiney G, Li M, Zou Y et al. · Cancer epidemiology · (2026) · View on PubMed ↗

Electronic tools to facilitate medication review in nursing homes: a pilot study.

This pilot study evaluated electronic tools (GheOP³S-tool and EBMeDS®CMR) to facilitate medication review (MR) in nursing home residents by community pharmacists. In one nursing home (Jan–Jul 2024), the 3-step MR workflow used electronic screening to detect potential drug-related problems (pDRPs) and assess the clinical and economic impact of implementing these tools. The study is significant as it tests scalable digital decision-support approaches to reduce medication-related harm and improve efficiency in long-term care.

Carrein M, Capiau A, Mehuys E et al. · Acta clinica Belgica · (2026) · View on PubMed ↗

Interfacial polarisation, electrical modulus and relaxation dynamics in composite ceramics for multiferroic applications.

This materials study examined interfacial polarization, electrical modulus, and relaxation dynamics in composite multiferroic ceramics composed of (1-x)BaTi0.9Zr0.1O3 and xLi0.5Fe2.5O4 (x = 0.00–0.15) synthesized by solid-state reaction. Increasing Li0.5Fe2.5O4 content refined microstructure (reduced grain size, increased dislocation density), enhanced interfacial polarization, and produced dielectric behavior consistent with thermally activated, non-Debye relaxation. These findings help tune composition to optimize dielectric performance for multiferroic device applications.

Gajula GR, Buddiga LR, Srinivas G et al. · Journal of colloid and interface science · (2026) · View on PubMed ↗

Mortality patterns in patients with chronic obstructive pulmonary disease and diabetes mellitus in the United States: a retrospective analysis from 1999 to 2019.

This retrospective analysis used the CDC WONDER database to study mortality patterns from 1999–2019 in US adults with chronic obstructive pulmonary disease (COPD) and diabetes mellitus (DM), reporting crude and age-adjusted mortality rates and trends via joinpoint regression. Overall mortality increased modestly over time (with an average annual percent change reported), and sex and racial/ethnic groups showed different mortality rates and trends. The results highlight persistent and evolving disparities in COPD–DM mortality in the United States, informing targeted public health and clinical interventions.

Fatima M, Fatima F, Raza A et al. · Journal of diabetes and metabolic disorders · (2026) · 1 citations · View on PubMed ↗ · Free PDF ↗

Reversible alterations of brain acetate metabolism associated with alcohol consumption.

This study investigated how alcohol consumption alters brain acetate metabolism in four groups—light drinkers, at-risk heavy drinkers, alcohol use disorder (AUD) patients in long-term recovery, and AUD treatment-seekers undergoing detoxification—using medically supervised scanning at about one week abstinence. The key finding was that brain acetate metabolism changes were reversible with abstinence and differed by drinking status, consistent with alcohol-related shifts in acetate utilization capacity. Scientifically, it links alcohol exposure to dynamic brain energy substrate remodeling, which may inform biomarkers or targets for AUD treatment.

Kumaragamage C, Jiang L, Angarita GA et al. · Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · (2026) · View on PubMed ↗ · Free PDF ↗

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Generated automatically on June 02, 2026. Covers PubMed articles published May 26, 2026 – June 02, 2026. Summaries are AI-generated; always consult the original publication for clinical or research decisions.