What's New in Cardiac MRI? — June 15, 2026
AI-summarised digest of 63 PubMed articles on Cardiac MRI published in the last 7 days.
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What’s New in Cardiac MRI?
June 15, 2026 · 63 articles · 15 research themes · covering June 08, 2026 – June 15, 2026
Overview
Across this week’s set, a dominant theme is moving from “single-number” clinical surrogates toward imaging-derived, mechanism-linked risk stratification. Multiple studies leverage cardiac MRI to identify patients at higher risk despite reassuring conventional metrics—such as supranormal LVEF in coronary disease, early myocardial involvement in Chagas cardiomyopathy, and early structural/functional signals in conditions like HIV-associated cardiac injury and Takotsubo syndrome. Complementing this, MRI-based hemodynamic frameworks (e.g., MRI-derived filling pressure/staging) and standardized coupling metrics (LA–LV coupling) aim to make physiology and remodeling more comparable across cohorts and centers.
A second major thread is refinement of myocardial tissue characterization and quantification—especially late gadolinium enhancement (LGE) interpretation, scar/edema proxies, and uncertainty-aware measurement. Reviews and methodological papers emphasize that prognostic value depends on acquisition and analysis details (including LGE “granularity”), while engineering work targets robust automated segmentation/strain and calibrated uncertainty for safer AI-assisted biomarkers. In parallel, new or alternative modalities (e.g., low-contrast dual-energy CT for scar/ECV, 7T feasibility for cine strain, and standardized thrombus volume quantification) broaden access while trying to preserve measurement fidelity.
Finally, the digest highlights the clinical importance of “mimics” and uncommon etiologies—drug-induced cardiomyopathies (hydroxychloroquine, dupilumab), infectious/parasitic cardiac disease (myocardial tuberculosis, toxoplasmosis, hydatid disease, sparganosis), and rare structural/conduction complications (e.g., constrictive physiology unmasked by HLA-B27 disease, congenital shunt mechanisms, and persistent conduction disease after Takotsubo). Together with case-based evidence for targeted interventions (e.g., aspiration thrombectomy for right atrial thrombus, SPS embolization in bronchiectasis), the overall message is that modern imaging not only stratifies risk but also clarifies diagnosis and guides management when standard workups are misleading or incomplete.
Cardiac MRI Prognosis & Risk Stratification (General)
MRI staging of haemodynamic congestion and clinical outcomes.
This European radiology study evaluated cardiovascular MRI-derived left ventricular filling pressure (MRI-wedge) and pulmonary blood volume index (PBVi) in patients staged into four MRI haemodynamic categories (normal profile, isolated volume overload, isolated pressure overload, and combined overload) and related them to non-invasive markers of myocardial fibrosis. The key finding was that MRI-wedge and PBVi-based haemodynamic staging had prognostic value and were associated with non-invasive fibrosis markers, supporting MRI haemodynamics as a risk-stratification framework. Clinically, this could improve prediction of outcomes in patients with haemodynamic congestion by linking MRI physiology to myocardial remodeling/fibrosis without relying solely on invasive measures.
Mantini C, Sorella A, Falco D et al. · European radiology · (2026) · View on PubMed ↗ · Free PDF ↗
Left Atrioventricular Coupling Index in Health and Disease: A Longitudinal Multicohort Analysis.
This Journal of Cardiovascular Magnetic Resonance longitudinal multicohort analysis evaluated the Left Atrioventricular Coupling Index (LACI), defined as the ratio of left atrial (LA) to left ventricular (LV) end-diastolic volume (EDV), across health and disease cohorts. The study aimed to define population-specific reference thresholds and determine how LACI relates to cardiac structure/function and whether it adds incremental predictive value beyond established markers. The significance is that LACI could become a more standardized, clinically implementable imaging biomarker for LA–LV coupling once reference ranges and prognostic utility are validated.
Roy R, Salatzki J, Szabo L et al. · Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · (2026) · View on PubMed ↗ · Free PDF ↗
Association of Subclinical Cardiac Remodeling With Incident Cancer in the MESA Cohort.
This analysis in the MESA (Multi-Ethnic Study of Atherosclerosis) cohort examined whether CMR-derived measures of subclinical cardiac remodeling are associated with incident cancer. Using multivariable Cox proportional hazards models, cardiac remodeling metrics from CMR were associated with future cancer risk (exact effect estimates are not visible in the truncated abstract). Scientifically, the study supports a shared pathophysiology between subclinical cardiovascular remodeling and cancer development, and may enable CMR-based risk stratification for cancer in population studies.
Cai X, White Q, Juarez J et al. · Journal of the American Heart Association · (2026) · View on PubMed ↗ · Free PDF ↗
Prognostic value of stress perfusion cardiac magnetic resonance in patients with known or suspected coronary artery disease and supranormal left ventricular ejection fraction.
This cohort study evaluated the prognostic value of stress perfusion cardiac magnetic resonance (CMR) in adults (≥18 years) with known or suspected coronary artery disease who had supranormal left ventricular ejection fraction (LVEF ≥65%) on CMR. The key finding was that stress perfusion CMR provided prognostic discrimination in this supranormal-LVEF population, identifying patients at higher risk despite preserved/high LVEF. Clinically, this supports using stress perfusion CMR risk stratification rather than relying on supranormal LVEF alone to predict adverse cardiovascular outcomes.
Pakdeesrisakda K, Kaolawanich Y · Open heart · (2026) · View on PubMed ↗ · Free PDF ↗
Cardiac imaging in Chagas cardiomyopathy for phenotypic characterisation and risk stratification.
This review article examined how cardiac imaging can be used to phenotype and risk-stratify patients with Chagas cardiomyopathy (CCM) caused by chronic Trypanosoma cruzi infection. It highlights that advanced imaging detects early myocardial involvement (e.g., fibrosis and arrhythmia risk substrates) that may be missed by conventional clinical markers, improving phenotypic characterization and risk stratification. Scientifically and clinically, it supports integrating modern cardiac imaging into CCM evaluation to better identify patients likely to progress to conduction disease, ventricular arrhythmias, and heart failure.
Johnson A, Katraj SVK, Pooranachandran V · Heart failure reviews · (2026) · View on PubMed ↗ · Free PDF ↗
Atrial Fibrillation & Left Atrial Remodeling (CMR/Imaging)
High resolution, 3D isotropic late gadolinium enhanced imaging for the quantification of left atrial fibrosis and post-ablation scarring.
This prospective study evaluated a high-resolution isotropic 3D late gadolinium enhancement (LGE) Dixon cardiovascular magnetic resonance sequence to quantify left atrial (LA) fibrosis in 40 ablation-naïve atrial fibrillation (AF) patients (paroxysmal vs persistent) and 20 healthy controls. The key finding was that the higher spatial resolution isotropic 3D LGE approach better depicts the thin LA wall and enables more accurate quantification of LA fibrosis and post-ablation scarring than conventional lower-resolution LGE methods. Clinically, this improves noninvasive characterization of atrial myopathy and may refine risk stratification and assessment of ablation-related structural remodeling in AF.
Fenski M, Hickstein R, Krüger LD et al. · European heart journal. Imaging methods and practice · (2026) · View on PubMed ↗
Valvular Heart Disease (Aortic/Mitral) & Post-Intervention Imaging
Quantification of mitral regurgitation: from traditional methods to artificial intelligence.
This review summarized how mitral regurgitation (MR) quantification has evolved from traditional echocardiographic geometric, single-frame methods to artificial intelligence (AI) approaches that analyze regurgitant flow throughout systole and account for eccentric or non-holosystolic jets and non-hemispheric orifice area. The key finding is that AI-based MR quantification from echocardiographic data can achieve favorable agreement with cardiac magnetic resonance (CMR) compared with conventional geometric assumptions. Clinically, this supports more accurate, automated MR grading—especially in complex jet morphologies where standard echocardiography is most error-prone.
Cho K, Su J, Bonnefous O et al. · Cardiovascular ultrasound · (2026) · View on PubMed ↗
Aortic Stenosis Progression: Lessons from Multimodality Imaging.
This narrative review studied the role of multimodality imaging in calcific aortic stenosis progression, focusing on how different imaging modalities assess valve calcification, metabolic activity, and severity over time. The key finding was that echocardiography, cardiac magnetic resonance, cardiac computed tomography, and nuclear imaging provide complementary “imaging checkpoints” that may better characterize disease biology than any single modality. Clinically, these imaging endpoints could be used to select and monitor patients and to serve as targets for trials aiming to halt or slow aortic stenosis progression.
Jain R, Padang R, Postalian A et al. · Mayo Clinic proceedings · (2026) · View on PubMed ↗
Cardiovascular magnetic resonance reclassification of aortic regurgitation after transcatheter aortic valve implantation: A COMPARE-TAVI 1 substudy.
This prespecified COMPARE-TAVI 1 substudy compared transthoracic echocardiography (TTE) and cardiovascular magnetic resonance (CMR) for reclassifying aortic regurgitation (AR) after transcatheter aortic valve implantation (TAVI) using VARC-3 criteria. The key finding was that CMR, which directly quantifies regurgitant flow, can reclassify AR severity compared with semiquantitative, operator-dependent TTE measurements in patients receiving Sapien 3/Sapien 3 Ultra or Myval/Myval Octacor valves. Scientifically and clinically, this supports CMR as a more reproducible tool for post-TAVI AR assessment and may improve consistency of outcomes reporting and patient management.
Pedersen AAU, Pedersen ALD, Mogensen NSB et al. · Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · (2026) · View on PubMed ↗ · Free PDF ↗
Impact of Concomitant Mitral Regurgitation in Moderate Aortic Stenosis: Assessment of Remodeling and Clinical Outcomes.
This cardiac MRI–based study analyzed 742 patients with at least moderate aortic stenosis (422 with moderate AS and 320 with severe AS) to determine how concomitant mitral regurgitation (MR) burden affects cardiac remodeling and clinical outcomes, comparing patients with moderate AS plus MR to those with isolated moderate or severe AS. The key finding was that MR burden in moderate AS was associated with distinct remodeling patterns and worse clinical outcomes, effectively identifying a higher-risk subgroup within “moderate” AS. These findings support incorporating MR severity into CMR-based risk assessment and may influence timing of intervention decisions for patients with dual valvular disease.
Gabr EM, Xiao M, Saeed M et al. · JACC. Cardiovascular imaging · (2026) · View on PubMed ↗
Coronary Artery Disease, Microvascular Dysfunction & Post-MI Remodeling
Inhibition of late sodium current (INa) to prevent coronary MICROvascular dysfunction in patients presenting with ST-elevation myocardial infarction and multivessel disease: A phase IIb multicenter, randomized, controlled and open label study (INaMICRON).
This phase IIb multicenter randomized controlled open-label trial (INaMICRON) studied whether early inhibition of the late sodium current with ranolazine, added to guideline-directed medical therapy, can prevent residual coronary microvascular dysfunction (CMD) in adults with ST-elevation myocardial infarction (STEMI) and multivessel disease after successful primary PCI. The trial’s key finding is not yet reported in the abstract excerpt, but the study design specifies randomization 1:1 to ranolazine vs control to test microvascular modulation during the early post-infarction phase. Scientifically, if effective, this strategy would provide a targeted pharmacologic approach to reduce ongoing ischemia and improve recovery by addressing microvascular dysfunction rather than only epicardial stenosis.
Di Serafino L, Ciaramella L, De Rosa S et al. · International journal of cardiology · (2026) · View on PubMed ↗
Myocardial Tissue Characterization (LGE/Mapping/Scar/Edema/IMH)
Intramyocardial Dissecting Hematoma After Myocardial Infarction Diagnosed by Multimodality Imaging.
This case report studied a 47-year-old man with myocardial infarction who initially had a left ventricular (LV) mass presumed to be thrombus and was evaluated with multimodality imaging. Cardiac magnetic resonance imaging using steady-state free precession cine and late infarct characterization identified extensive anterior transmural infarction with a dissecting intramyocardial cavity consistent with intramyocardial dissection. Clinically, recognizing intramyocardial dissection as a thrombus mimic is important because anticoagulation alone may fail and the diagnosis can change urgent management in post-MI mechanical complications.
Borg BC, Josephs C, Ghincea C et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗
Clinical Importance of All the Characteristics of Late Gadolinium Enhancement from Acquisition to Expert and Artificial Intelligence Analysis: State-of-the-Art.
This state-of-the-art review studied how late gadolinium enhancement (LGE) “granularity” (location, extent, and pattern) and technical factors from acquisition to expert and artificial intelligence analysis affect clinical interpretation. The key finding was that LGE prognostic value depends on multiple variables—including contrast-media choice, post-processing, and interpretation method—so comprehensive characterization is more informative than simple presence/extent alone. Clinically, standardizing and reporting LGE acquisition/analysis details can improve risk stratification across cardiac diseases and enhance the reliability of AI-assisted LGE interpretation.
Florence J, Unger A, Gonçalves T et al. · Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · (2026) · View on PubMed ↗ · Free PDF ↗
Predicting Intramyocardial Hemorrhage Before Reperfusion in STEMI Patients With Intrinsically Explainable Artificial Intelligence.
This study developed and validated an intrinsically explainable artificial intelligence model to predict intramyocardial hemorrhage (IMH) before reperfusion in 288 STEMI patients from the MIRON-PREDICT study. The key finding was that the explainable AI approach produced a bedside score that identifies patients at risk of IMH prior to reperfusion using pre-reperfusion electrocardiographic, angiographic, and clinical variables. Clinically, early IMH risk prediction could guide treatment decisions and monitoring strategies in reperfused STEMI.
Youssef K, Vora KP, Gupta R et al. · JACC. Advances · (2026) · View on PubMed ↗ · Free PDF ↗
The Feasibility of Low Contrast Dose Dual-energy CT for Quantifying Myocardial Focal Scar via Extracellular Volume Fraction.
This prospective study evaluated the feasibility of low-contrast-dose dual-energy CT (DECT) to quantify myocardial focal scar (MFS) using extracellular volume (ECV) in 33 patients with old myocardial infarction. It compared DECT late iodine enhancement (LIE)-ECV against cardiac MRI late gadolinium enhancement (LGE)-ECV and found quantitative agreement for measuring ECV in MFS and remote myocardium on corresponding slices. Scientifically and clinically, low-dose DECT ECV quantification could offer a radiation- and contrast-sparing alternative for scar quantification when MRI is unavailable.
Chen F, Jia T, Luo L et al. · The British journal of radiology · (2026) · View on PubMed ↗
Myocardial salvage and functional recovery prediction: T1 rho vs conventional CMR in acute myocardial infarction.
This prospective acute myocardial infarction (AMI) study evaluated whether T1 rho–based CMR measures of edema-defined area at risk (AAR) and infarcted myocardium can predict adverse left ventricular remodeling after reperfused AMI. In 60 PCI-treated AMI patients with follow-up CMR at 3 months, both edema-defined AAR and infarcted myocardium were detectable by T1 rho, and the study assessed T1 rho–derived cutoffs for predicting convalescent remodeling (full cutoff/results are truncated). Scientifically and clinically, it suggests T1 rho may improve prediction of functional recovery and remodeling compared with conventional CMR approaches.
Guo M, Qian Y, Wu C et al. · Magnetic resonance imaging · (2026) · View on PubMed ↗
Hypertrophic Cardiomyopathy (HCM) Risk, Phenotype & Surveillance
Apical Hypertrophic Cardiomyopathy and Elite-Level Sports: A 12-Year Follow-Up Case.
This 12-year follow-up case report described an elite athlete with apical hypertrophic cardiomyopathy (aHCM) to assess whether long-term high-level sports participation affected cardiac morphology and fibrosis progression. The key finding was that despite elite-level competition from ages 17 to 31 and later cessation, there were no adverse morphologic changes and no progression of apical fibrosis or disease. Scientifically and clinically, it supports that aHCM may have a more favorable long-term interaction with elite sports than other HCM phenotypes, though conclusions remain limited to a single case.
Thio Q, van Hattum J, Nijland F et al. · JACC. Case reports · (2026) · View on PubMed ↗
Prognostic Value of MRI-Based Left Ventricular Trabecular Complexity for Sudden Cardiac Death in Hypertrophic Cardiomyopathy.
This prospective study evaluated whether left ventricular (LV) myocardial trabecular complexity quantified by fractal dimension (FD) on 3T steady-state free precession (SSFP) cardiac MRI predicts sudden cardiac death (SCD) in 835 hypertrophic cardiomyopathy (HCM) patients. The key finding was that higher LV trabecular complexity (FD) was associated with increased SCD risk and related to underlying sarcomere genetic variants. Scientifically and clinically, FD-based trabecular complexity could improve early identification of high-risk HCM patients for preventive interventions.
Zhang J, Yu M, Pu L et al. · Journal of magnetic resonance imaging : JMRI · (2026) · View on PubMed ↗
Puberty-Associated Emergence of Hypertrophic Cardiomyopathy: When Genetics Meets Growth.
This case report describes a 13-year-old asymptomatic boy with a strong family history of hypertrophic obstructive cardiomyopathy who later showed puberty-associated emergence of hypertrophic cardiomyopathy, illustrating how genotype-positive individuals may develop phenotype during adolescence. The key finding was that clinical/echocardiographic manifestations of HCM emerged in association with growth/puberty timing, consistent with incomplete penetrance and developmental modifiers of gene-driven disease expression. Scientifically, it underscores the need for longitudinal surveillance of genotype-positive children through adolescence and suggests growth-related factors may influence phenotypic conversion.
Mashiah G, Schamroth N, Yaeger-Yarom G et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗
Cardiac Magnetic Resonance Imaging Parameters Predict New-Onset Symptoms of Heart Failure in Hypertrophic Cardiomyopathy.
This single-center retrospective cohort studied hypertrophic cardiomyopathy (HCM) patients to identify cardiac magnetic resonance (CMR) imaging parameters predicting new-onset heart failure (HF) symptoms. CMR-derived measures of cardiac structure/function (specific parameters not shown in the truncated abstract) were associated with subsequent development of HF symptoms. These findings support using CMR phenotyping to improve risk stratification for HF symptom onset in HCM, potentially guiding earlier monitoring and management.
da Silva DS, Karlinski Vizentin V, Ferreira Felix I et al. · ESC heart failure · (2026) · View on PubMed ↗ · Free PDF ↗
Predictors of Long-Term Outcomes in Hypertrophic Cardiomyopathy: The NHLBI HCM Registry.
This registry-based study from the NHLBI HCM Registry (2750 patients with hypertrophic cardiomyopathy across 44 North American/European sites) aimed to improve prediction of adverse outcomes by integrating clinical history, imaging, genetic, and biomarker data. The investigators developed/assessed an enhanced risk prediction approach beyond existing guidelines that primarily target sudden cardiac death, using prospectively collected multimodal data including cardiac magnetic resonance (CMR). Clinically, better individualized risk prediction could reduce both preventable deaths and unnecessary implantable cardioverter defibrillator use in HCM.
Kramer CM, Kolm P, DiMarco JP et al. · JAMA · (2026) · 1 citations · View on PubMed ↗ · Free PDF ↗
Heart Failure & Ventricular Remodeling (Non-HCM)
Impact of systemic-to-pulmonary artery shunt embolization on right heart hemodynamics in patients with bronchiectasis.
This prospective study assessed whether embolization of systemic-to-pulmonary artery shunts (SPS) improves right heart hemodynamics in patients with bronchiectasis, using right heart catheterization and cardiac magnetic resonance (CMR) before and within 24–48 hours after SPS embolization. The key finding was that post-embolization changes in hemodynamic parameters (including stroke volume, cardiac index/output, pulmonary artery pressure, pulmonary artery wedge pressure, and shunt oxygen saturation) reflected improved right heart physiology. Clinically, demonstrating early hemodynamic benefit supports SPS embolization as a targeted intervention to reduce shunt-related cardiopulmonary burden in bronchiectasis.
Wu H, Jiang F, Guo L et al. · Journal of vascular and interventional radiology : JVIR · (2026) · View on PubMed ↗
Right Ventricular Remodeling in Repaired Tetralogy of Fallot: Imaging, Arrhythmia Risk, and Timing of Pulmonary Valve Replacement.
This review studied right ventricular (RV) remodeling after repaired tetralogy of Fallot (rTOF), focusing on imaging correlates, arrhythmia risk mechanisms, and the timing of pulmonary valve replacement. It found that progressive RV dilatation and geometry changes driven by chronic pulmonary regurgitation, residual outflow obstruction, fibrosis, and electromechanical dyssynchrony create an arrhythmogenic substrate that evolves over time. Clinically, the synthesis supports using multimodal imaging and risk stratification to optimize pulmonary valve replacement timing and reduce late ventricular arrhythmia and sudden death risk.
Fatima H, Akram MB, Sher A et al. · Cardiology in review · (2026) · View on PubMed ↗
Association Between HIV Infection Duration and Left Ventricular Concentric Remodeling and Myocardial Fibrosis: A Cross-Sectional Study Using Cardiac MRI.
This cross-sectional prospective cardiac MRI study assessed 83 HIV-infected participants (infection duration <5 years vs ≥5 years) and 34 matched HIV-negative controls to determine associations between HIV duration and LV concentric remodeling and myocardial fibrosis. Using 1.5T SSFP cine and MOLLI T1 mapping, the study found that longer HIV infection duration was linked to worse LV remodeling metrics (e.g., increased LV mass-to-volume ratio and concentric changes) and greater myocardial fibrosis burden. Clinically, these MRI markers suggest cumulative HIV-related cardiac injury and may help identify patients who need earlier cardiovascular monitoring and risk reduction.
Deng C, Sun W, Gao T et al. · Journal of magnetic resonance imaging : JMRI · (2026) · View on PubMed ↗ · Free PDF ↗
Sinus Node Dysfunction in Takotsubo Syndrome: An Uncommon Presentation.
This JACC Case Reports article describes a 68-year-old patient with Takotsubo syndrome in whom sinus node dysfunction (SND) developed during hospitalization. The key finding was that although left ventricular systolic function fully recovered after stress cardiomyopathy, the conduction abnormality persisted, necessitating permanent pacemaker implantation. The case is clinically significant because it shows that Takotsubo can be complicated by persistent conduction system disease, not just transient LV dysfunction.
Zakynthinos GE, Kalogeras K, Vlachojannis GJ et al. · JACC. Case reports · (2026) · 1 citations · View on PubMed ↗ · Free PDF ↗
Recurrent Takotsubo Cardiomyopathy Triggered by COVID-19 Infection Complicated by Ventricular Tachycardia Arrest and Cardiogenic Shock: A Case Report.
This Cureus case report describes a 73-year-old Hispanic woman with prior Takotsubo cardiomyopathy who developed recurrent Takotsubo after COVID-19 infection, complicated by ventricular tachycardia arrest and cardiogenic shock. The key finding was that SARS-CoV-2 infection triggered recurrence with severe malignant arrhythmia and shock. Clinically, it emphasizes that COVID-19 can precipitate recurrent stress cardiomyopathy with life-threatening complications, supporting close monitoring for arrhythmias and hemodynamic deterioration.
Gonzalez Alvarez RR · Cureus · (2026) · View on PubMed ↗ · Free PDF ↗
The association between current CD4 counts and subclinical myocardial injury by cardiac magnetic resonance in HIV: independence from cardiovascular risk factors.
This prospective study enrolled 98 people with HIV (PWH) without known cardiovascular disease and 91 Framingham Risk Score–matched non-HIV controls to test whether immune status (including current CD4+ counts) is associated with subclinical myocardial injury on CMR independent of cardiovascular risk factors. CMR tissue characterization using native T1/T2 mapping, extracellular volume fraction (ECV), and late gadolinium enhancement (LGE) showed an association between current CD4 counts and markers of subclinical myocardial injury that was independent of traditional cardiovascular risk factors. Clinically, this links immune status and HIV disease control to early cardiac injury detectable by CMR, suggesting a potential target for risk reduction before overt cardiovascular disease.
Gan Y, Zhan Y, Zhang R et al. · AIDS (London, England) · (2026) · View on PubMed ↗
Takotsubo Syndrome: From Pathophysiology and Diagnosis to Management.
This narrative review summarized current knowledge on Takotsubo syndrome (TTS), focusing on pathophysiology, diagnosis, and management in patients presenting with acute heart failure–like syndromes. It emphasizes that TTS typically involves transient left ventricular dysfunction with regional wall motion abnormalities beyond a single coronary territory in the absence of culprit coronary lesions, often triggered by emotional or physical stress and mediated by multifactorial mechanisms including catecholamine-related cardiotoxicity and microvascular dysfunction. The review’s significance is to consolidate diagnostic and therapeutic concepts for clinicians managing TTS that can mimic acute myocardial infarction.
Marschall A, Salamanca J, Cecconi A et al. · The American journal of cardiology · (2026) · View on PubMed ↗
Independent prognostic value of left ventricular stroke volume index in patients with takotsubo syndrome: insights from the EVOLUTION registry.
This observational study using the EVOLUTION registry assessed prognostic value of cardiac magnetic resonance (CMR)–derived left ventricular stroke volume indexed (LVSVi) in patients with Takotsubo syndrome (TTS). Patients underwent CMR at a median of 5 days after admission and were categorized by LVSVi (<35 vs ≥35 mL/m²), with follow-up to 360 days for major adverse cardiovascular events and all-cause death (exact hazard estimates are truncated). The clinical significance is that LVSVi may serve as an early CMR biomarker to stratify risk in TTS beyond conventional clinical assessment.
Arcari L, Cau R, Pontone G et al. · Heart (British Cardiac Society) · (2026) · View on PubMed ↗
Pericardial Disease & Constrictive Physiology
Left ventricular strain and hemodynamic forces from cine CMR for detecting constrictive physiology in pericarditis.
This retrospective diagnostic study evaluated cine CMR-derived left ventricular strain and hemodynamic forces (HDF) to distinguish constrictive physiology (CP) from non-constrictive physiology (NCP) in patients with CMR-confirmed pericarditis. Using guideline-defined noninvasive clinical/imaging criteria for classification, the study found that quantitative cine-based strain and HDF metrics improved diagnostic discrimination of CP versus NCP compared with largely qualitative CMR assessment. Clinically, this supports a more objective, quantitative CMR approach for timely identification of constrictive physiology in pericarditis.
Vollbrecht TM, Proff A, Juraschitz S et al. · Insights into imaging · (2026) · View on PubMed ↗
Constrictive Pericarditis and Bilateral Pleural Effusions Unmasked in an HLA-B27 Positive Patient.
This case report studied a 40-year-old HLA-B27–positive man in whom constrictive pericarditis (CP) and bilateral pleural effusions were unmasked after an initial presentation consistent with acute pericarditis. The key finding was that extensive workup was unrevealing except for HLA-B27 positivity, and the patient progressed to constrictive physiology requiring radical pericardiectomy with symptom resolution. The clinical significance is that HLA-B27–associated spondyloarthropathy may be a previously underrecognized contributor to CP, guiding diagnostic consideration and management.
Villalonga M, Al-Dalakta A, El Roumi J et al. · JACC. Case reports · (2026) · View on PubMed ↗
Cardiotoxicity & Drug-Induced Myocardial Disease (e.g., HCQ, Dupilumab)
Hydroxychloroquine-associated cardiomyopathy with nondiagnostic noninvasive evaluation: diagnostic value of endomyocardial biopsy in a case-based review.
This case-based review examined diagnostic challenges in hydroxychloroquine (HCQ)-associated cardiomyopathy when noninvasive evaluation is nondiagnostic, focusing on a 57-year-old woman with Sjögren’s disease treated with HCQ 400 mg daily for nearly 21 years (cumulative dose ~3,000 g). The report highlights that endomyocardial biopsy provided diagnostic value when standard noninvasive tests failed to clarify HCQ cardiotoxicity. Scientifically and clinically, it supports considering endomyocardial biopsy in suspected HCQ cardiomyopathy with inconclusive imaging/clinical workup to enable timely diagnosis and management.
Alkhatib A, Al-Kofahi M, Abumuhfouz M et al. · Rheumatology international · (2026) · View on PubMed ↗
Eosinophilic Cardiomyopathy in Eosinophilic Granulomatosis With Polyangiitis After Dupilumab Therapy.
This case report studied a 64-year-old man who developed eosinophilic cardiomyopathy after starting dupilumab, an IL-4Rα antagonist, in the setting of eosinophilic granulomatosis with polyangiitis (EGPA). The key finding was that three months after dupilumab initiation he developed marked hypereosinophilia and cardiac dysfunction, with echocardiography/cardiac MRI showing left ventricular involvement and endomyocardial biopsy confirming eosinophilic myocarditis. Clinically, it highlights a rare but severe adverse inflammatory cardiac complication temporally associated with dupilumab and supports prompt immunosuppression (high-dose corticosteroids plus cyclophosphamide) when suspected.
Agredano I, Michiels V, Argacha JF et al. · JACC. Case reports · (2026) · View on PubMed ↗
Hydroxychloroquine Cardiotoxicity Confirmed by Electron Microscopy: The Myocarditis Mimic.
This JACC Case Reports article described a 79-year-old woman with long-term hydroxychloroquine (HCQ) exposure who presented with low-output physiology and symptoms mimicking inflammatory cardiomyopathy. Cardiac magnetic resonance showed diffuse patchy midmyocardial and subepicardial late gadolinium enhancement, while positron emission tomography demonstrated diffuse fluorodeoxyglucose uptake sparing the subendocardium, and endomyocardial biopsy with electron microscopy confirmed HCQ cardiotoxicity with cardiomyocyte vacuolization. The case is significant because it demonstrates that HCQ cardiotoxicity can closely mimic myocarditis on imaging, emphasizing the need for tissue confirmation and careful medication history in suspected inflammatory cardiomyopathy.
Behr P, Paik KS, Park C et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗
Infectious/Parasitic Cardiac Disease (TB, Toxoplasma, Hydatid, etc.)
Hemorrhagic Eosinophilic Pericardial Effusion Associated With Probable Sparganosis.
This case report described a 25-year-old man with hemorrhagic eosinophilic pericardial effusion after ingesting undercooked frog meat, with diagnostic workup suggesting probable sparganosis due to peripheral eosinophilia, eosinophils in pericardial fluid, and markedly elevated immunoglobulin E. Despite extensive testing including cultures, cytology, cross-sectional imaging, CMR, positron emission tomography/computed tomography, and next-generation sequencing, no alternative cause was identified. The clinical significance is that sparganosis should be considered in hemorrhagic eosinophilic pericardial effusion with high IgE and eosinophilia, even when advanced imaging and molecular tests are unrevealing.
Zhu Y, Wang D, Wu Y et al. · International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · (2026) · View on PubMed ↗
Myocardial tuberculosis: a diagnostic challenge illustrated by two cases and review of contemporary management.
This article presented two clinical cases and a review of contemporary management of myocardial tuberculosis, an extrapulmonary tuberculosis form with variable presentations that can mimic other cardiac diseases. In both reported patients treated with first-line anti-tuberculosis therapy (with one also receiving corticosteroids and therapeutic anticoagulation), clinical and radiological outcomes were favorable. The significance is that myocardial tuberculosis should be included in the differential diagnosis of myocarditis/pericardial or mass-like cardiac presentations, particularly in appropriate epidemiologic contexts.
Tremouilhac EM, Richaud C, Tresorier R et al. · The international journal of cardiovascular imaging · (2026) · View on PubMed ↗
Osteosarcoma in a Young Patient: When the Tumor Reaches the Heart.
This case report studied a 17-year-old boy with prior osteosarcoma who developed cardiac symptoms due to rare cardiac metastasis. The key finding was that transthoracic echocardiography and cardiac magnetic resonance with late gadolinium enhancement identified a malignant-appearing intracardiac mass, and surgical resection with histopathology confirmed metastatic osteosarcoma. The clinical significance is that cardiac metastasis from osteosarcoma, though rare, should be considered when young patients present with intracardiac masses and prior malignancy, enabling timely definitive diagnosis and treatment.
Melem IC, Baratta SJ, Gutierrez G et al. · JACC. Case reports · (2026) · View on PubMed ↗
Amazonian toxoplasmosis complicated by severe hypoxemic pneumonia and myopericarditis in an immunocompetent adult.
This case report describes an immunocompetent adult with Amazonian toxoplasmosis complicated by severe hypoxemic pneumonia and documented myopericarditis. The key finding was that cardiac involvement can occur even in immunocompetent patients and may be clinically silent early, making diagnosis challenging when symptoms are nonspecific. Clinically, the report emphasizes considering toxoplasmosis in relevant geographic/exposure contexts and actively evaluating for cardiac involvement when systemic disease is severe.
Fréville B, Herrebrecht C, Samawak C et al. · BMC infectious diseases · (2026) · View on PubMed ↗ · Free PDF ↗
Isolated Cardiac Hydatid Disease Presenting as Ventricular Remodeling and Tamponade.
This JACC Case Reports report describes a 16-year-old woman with isolated cardiac hydatid disease presenting with a large intact pericardial hydatid cyst, myocardial thinning, concentric hypertrophy of uninvolved LV segments, active pericarditis, and tamponade physiology. The key finding was that imaging and intraoperative findings demonstrated an intact hydatid cyst causing pericardial effusion with tamponade and secondary ventricular remodeling. Clinically, it underscores that echinococcal cardiac involvement can present as tamponade with myocardial remodeling, emphasizing the need for multimodality imaging and prompt surgical/infectious management.
Yousuf Q, Rashid A, Choh NA et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗
Clinical significance of incidental pericardial late gadolinium enhancement on cardiac magnetic resonance.
This International Journal of Cardiology retrospective single-center study assessed the clinical significance of incidentally detected pericardial late gadolinium enhancement (LGE) on cardiac MRI in patients undergoing CMR for unrelated indications. The key finding was that incidental pericardial LGE—often assumed to represent active inflammation—may carry prognostic implications consistent with persistent subclinical inflammatory processes, compared with patients without pericardial LGE. Scientifically and clinically, it suggests that incidental pericardial LGE should not be dismissed and may help refine long-term risk stratification.
Lepre V, Moretto N, De Martino M et al. · International journal of cardiology · (2026) · View on PubMed ↗ · Free PDF ↗
Ovarian Endometrioid Carcinoma Presenting With Presumed Right Ventricular Intracardiac Metastasis and Superimposed Thrombus: A Rare Manifestation of Gynecologic Malignancy.
This case report described a 69-year-old woman with FIGO grade 3 ovarian endometrioid carcinoma who presented with a presumed right ventricular intracardiac metastasis and superimposed thrombus. Diagnostic work-up after oncologic imaging identified a right ventricular mass with thrombus, and the report highlights the rarity of gynecologic malignancy causing intracavitary right ventricular involvement. The clinical significance is heightened awareness that cardiac metastasis with thrombus can occur in advanced gynecologic cancers, affecting diagnostic urgency and management planning.
Memon M · Cureus · (2026) · View on PubMed ↗ · Free PDF ↗
Cardiac Echinococcosis: Rare and Challenging Presentations-A Case Series.
This retrospective case series reviewed five patients with cardiac echinococcosis (hydatid cysts) managed at a single center between 2009 and 2024. In all cases, while initial work-up used X-ray and/or transthoracic echocardiography, cardiac magnetic resonance (CMR) confirmed the diagnosis and characterized cyst locations (including intramyocardial/epicardial layers, interventricular septum, and right atrium). The significance is that CMR can be crucial for diagnosing rare cardiac hydatid disease, especially in endemic regions evaluating cardiac cystic masses.
Delibaş D, Soylu BG, Yumak T et al. · Journal of clinical ultrasound : JCU · (2026) · View on PubMed ↗
Congenital Heart Disease & Shunt Physiology
Evaluation of an unbalanced right dominant atrioventricular canal with a single 4D flow dataset.
This report presents a pediatric case of an unbalanced, right-dominant atrioventricular (AV) canal where preoperative decision-making (single ventricle palliation versus biventricular repair) relied on a novel imaging workflow using a single brief cardiac MRI 4D flow dataset. The key finding was that this limited 4D flow acquisition was sufficient to accurately estimate ventricular volumes and AV valve sizes for surgical planning. The case suggests that streamlined 4D flow MRI protocols may improve feasibility and accuracy of preoperative assessment in complex congenital heart disease.
Ream S, Schoeneberg L, King W · Journal of cardiothoracic surgery · (2026) · View on PubMed ↗ · Free PDF ↗
Flow-Driven Right-to-Left Shunting Through the Patent Foramen Ovale Causing Hypoxemia and Embolism in a Partial Uhl Anomaly.
This JACC Case Reports article describes a 49-year-old woman with partial Uhl anomaly in whom multimodality imaging identified a permanent right-to-left shunt through a patent foramen ovale (PFO) causing hypoxemia and embolism. The key finding was that the shunt occurred despite normal right-sided pressures, driven by flow redirection related to the congenital right ventricular abnormality. The case highlights a non-pressure-dependent mechanism of PFO-mediated hypoxemia/embolism in rare congenital heart disease, informing diagnostic evaluation when hypoxemia and stroke occur without elevated right-sided pressures.
Laboratto LE, Vannoni G, Nieto G et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗
Right Ventricular Apical Hypoplasia With a Novel Morphologic Presentation: The “Christmas Hat” Sign.
This JACC Case Reports article presents a 9-year-old boy with chronic cyanosis and digital clubbing found to have right ventricular apical hypoplasia with a novel “Christmas hat” morphology on multimodal imaging. Cardiac MRI showed compensatory left ventricular apex elongation projecting rightward, creating the distinctive “Christmas hat” configuration. The report expands the phenotypic spectrum of congenital RV apical hypoplasia and supports CMR’s role in defining unique ventricular geometry relevant to diagnosis and follow-up.
Meléndez-Ramírez G, Patrón-Chi SA, Figueroa-Galván FS et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗
Thrombus, Embolism & Anticoagulation/Thrombectomy
A simplified geometric CMR method for reproducible quantification of left ventricular thrombus volume : Left Ventricular thrombus: a standardized measurement method.
This post-hoc analysis evaluated a simplified geometric cardiac magnetic resonance (CMR) method for standardized left ventricular thrombus (LVT) volume quantification in patients from the COVERT-MI trial who underwent CMR about 5 days after reperfusion for ST-segment elevation myocardial infarction. The approach was feasible and showed improved reproducibility for measuring LVT volume compared with less standardized geometric assessments. Standardizing LVT volume measurement with reproducible CMR could strengthen studies linking thrombus characteristics to clinical evolution and potentially improve risk stratification for systemic embolism after myocardial infarction.
Fuzeau A, Angoulvant D, Pucheux J et al. · The international journal of cardiovascular imaging · (2026) · View on PubMed ↗
Congenital Absence of the Left Atrial Appendage in Atrial Fibrillation With Gastrointestinal Bleeding.
This JACC Case Reports report describes a 78-year-old man with permanent atrial fibrillation and recurrent obscure gastrointestinal bleeding who was evaluated for left atrial appendage (LAA) occlusion. Transesophageal echocardiography and cardiac MRI demonstrated congenital absence of the LAA with no atrial thrombus, leading clinicians to reconsider anticoagulation strategy given the patient’s high bleeding risk. The case highlights a rare anatomic variant that can materially affect thromboembolic risk assessment and anticoagulation/occlusion decisions in AF.
Nashtar MA, Steinmetz M, Trippe J et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗
Percutaneous Aspiration Thrombectomy for a Large Right Atrial Thrombus in a Critically Ill Patient.
This case report describes a 52-year-old dialysis-dependent woman with type 1 diabetes and prior pancreas and kidney transplantation who developed catheter-related sepsis and a large right atrial thrombus (4 × 2 cm) detected by transesophageal echocardiography and cardiac MRI. Because surgical risk was prohibitive, percutaneous aspiration thrombectomy using the FlowTriever system achieved near-complete thrombus removal, with residual thrombus treated using systemic anticoagulation. The report provides practical evidence that FlowTriever–based aspiration can be a feasible, life-saving option for large infected right atrial thrombi when surgery is not viable.
Nashtar MA, Steinmetz M, Schnitzbauer A et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗
Cardiac Imaging Methods, Quantification & Standardization (including AI/Uncertainty)
Cardiac function and myocardial strain analysis at 7T using B1 shimming in comparison to 3T magnetic resonance imaging.
This study compared cardiac function and myocardial strain measurements at 7 Tesla versus 3 Tesla MRI in ten healthy volunteers, using B1 shimming to mitigate transmit B1 inhomogeneity for cine imaging. The key finding was that an efficient workflow using a single B1 shim set (derived from B1 mapping to compute a single B1 phase-shim vector applied across the exam) enabled assessment of volumetric and strain parameters at 7T with acceptable image quality. Scientifically, it supports feasibility of 7T cardiac cine strain analysis, which could improve measurement precision if workflow robustness translates to clinical practice.
Jung B, Hundertmark M, Peters AA et al. · The international journal of cardiovascular imaging · (2026) · View on PubMed ↗
Modeling Aleatoric Uncertainty in Cardiac MRI Segmentation: Probabilistic Detection and Contour Regression.
This methodological study investigated modeling aleatoric uncertainty in cardiac MRI segmentation using probabilistic detection and contour regression to better quantify uncertainty in derived biomarkers such as left and right ventricular ejection fraction (LVEF/RVEF). The key finding was that evaluating uncertainty at the biomarker level (not just average segmentation accuracy) is feasible and can improve calibration of uncertainty estimates for individual patients. Clinically, better-calibrated uncertainty can increase trust in AI-derived cardiac biomarkers and support safer decision-making when segmentation ambiguity is high.
Zhao Y, Zhang Y, Tourais J et al. · IEEE transactions on medical imaging · (2026) · View on PubMed ↗ · Free PDF ↗
Segmental strain in chronic ischemic cardiomyopathy: clarifying the role of multiple-comparison adjustment and the clinical interpretation of limits of agreement.
This methodological paper examined how segmental LV longitudinal strain results from feature-tracking cardiac magnetic resonance (FT-CMR) and 2D speckle-tracking echocardiography (2D-STE) should be interpreted when multiple-comparison adjustment is applied in chronic ischemic cardiomyopathy. The authors emphasized that segment-level paired comparisons require explicit multiplicity control and that limits of agreement should not be used to treat the two modalities as interchangeable for individual patient assessment or longitudinal follow-up. Scientifically, the work clarifies statistical and clinical interpretation of strain “agreement” across imaging platforms, reducing misclassification of disease progression.
Malik MMUD, Jayaswal RP · Journal of cardiovascular imaging · (2026) · View on PubMed ↗ · Free PDF ↗
Parameter-efficient adaptation of foundational models for automated myocardial strain analysis.
This engineering study investigated parameter-efficient adaptation of foundational models for automated myocardial strain analysis across imaging domains. The authors developed CardiacSAM, a lightweight Segment Anything Model (SAM) fine-tuned with low-rank adaptation (LoRA) for cardiac structure segmentation, paired with uniGradICON for myocardial motion estimation, enabling robust cross-scanner strain estimation with minimal adaptation data. Scientifically, this approach reduces the data burden and improves generalizability of automated strain pipelines for clinical deployment.
Bernardo A, Mato G, Calandrelli M et al. · Biomedical physics & engineering express · (2026) · View on PubMed ↗ · Free PDF ↗
NOTO: Noise-Tolerate Evidential Learning for Open-Set Cross-modal Retrieval.
This paper proposes NOTO (Noise-Tolerate Evidential Learning) for open-set cross-modal retrieval, addressing scenarios where training labels are noisy and new/unseen categories appear (open-set noisy labels, OSNL). The key finding is that evidential learning with noise-tolerant mechanisms improves retrieval robustness under combined label noise and open-set category shifts compared with conventional closed-set cross-modal retrieval methods. Scientifically, it advances multimodal retrieval methods that better reflect real-world annotation imperfections and evolving category spaces.
Pu R, Su C, Hu P et al. · IEEE transactions on image processing : a publication of the IEEE Signal Processing Society · (2026) · View on PubMed ↗
Advanced Imaging Biomarkers & Molecular Imaging (PET/MR, adrenal–cardiac axis)
Primary Aldosteronism: CXCR4- and FAP-Targeted PET/MR for Adrenal-Cardiac Axis.
This study evaluated the adrenal–cardiac axis in 82 participants with primary aldosteronism (40; including 21 aldosterone-producing adenoma and 19 idiopathic hyperaldosteronism) versus 42 with essential hypertension using CXCR4-targeted 68Ga-Pentixafor PET/MR and FAP-targeted 68Ga-FAPI-04 PET combined with cardiac MRI. Key findings showed that CXCR4- and FAP-mediated molecular signals in the adrenal and myocardium were linked to myocardial remodeling in primary aldosteronism beyond hemodynamic burden. These in vivo imaging results support a mechanistic role for adrenocortical activity in myocardial fibroblast activation and suggest CXCR4/FAP PET/MR as a translational tool for risk stratification in PA.
Ding J, Wang K, Song J et al. · Circulation. Cardiovascular imaging · (2026) · View on PubMed ↗
Cardiovascular effects of metyrapone treatment in patients with mild autonomous cortisol secretion: a secondary analysis.
This secondary analysis studied 15 patients with mild autonomous cortisol secretion (MACS) (12 females; mean age 59) before and after 12 weeks of evening metyrapone (500 mg at 6 p.m. and 250 mg at 10 p.m.) to assess blood pressure regulation, cardiac fat depots, heart function/morphology, and cardiovascular risk factors. The key finding was that cortisol-lowering with metyrapone produced measurable changes in cardiovascular parameters related to blood pressure regulation and cardiac structure/fat, consistent with a causal contribution of excess cortisol to cardiovascular risk in MACS. Clinically, these results strengthen the rationale for medical cortisol suppression as a potential strategy to mitigate cardiovascular morbidity in MACS.
Niziolek H, Just I, Baumgartner C et al. · The Journal of clinical endocrinology and metabolism · (2026) · View on PubMed ↗ · Free PDF ↗
Non-Cardiac Clinical/Health Services & Public Health (beyond cardiology)
Current landscape of paediatric and young adult cardio-oncology care in Latin America.
This cross-sectional survey characterized the current landscape of paediatric and adolescent cardio-oncology care across Latin America, focusing on workforce training, clinical infrastructure, diagnostic resources, follow-up strategies, and research capacity among healthcare professionals. The study identified substantial variability and gaps in specialized training, infrastructure, imaging/diagnostic resources, and structured follow-up and research capability across countries and centers. Mapping these deficiencies is clinically important for guiding targeted investments and harmonizing cardio-oncology services for childhood cancer survivors at elevated lifetime cardiovascular risk.
Stelmaszewski EV, Biancolini J, Gonzalez Ortiz A et al. · Cardiology in the young · (2026) · View on PubMed ↗
Parasitically coupled 16-port massive MIMO antenna for mmWave applications.
This engineering study designed and evaluated a compact 16-port parasitically coupled massive MIMO antenna for millimeter-wave (mmWave) applications, using a structure with five triangular parasitic elements, a triangular feed-line element, and impedance matching with defected ground and stubs. The antenna was optimized to resonate at 40 GHz and was implemented by replicating a single-element design with a modified ground-plane structure. This is significant for mmWave massive MIMO systems because the compact multiport design can improve scalability and performance at 40 GHz.
Mishra B, Sharma H, Misra NK et al. · Scientific reports · (2026) · View on PubMed ↗
Nurses’ Clinical Decision-Making During Peripherally Inserted Central Catheter Dressing Application and Removal: A Qualitative Study.
This qualitative study investigated how registered nurses in adult and pediatric cancer wards in Brisbane, Australia make clinical decisions when applying and removing peripherally inserted central catheter (PICC) dressings and securement devices. The key finding was that nurses’ reasoning during PICC dressing application/removal followed structured decision-making patterns captured using the Think Aloud method and analyzed with Framework Analysis mapped to Dual Process Theory. Scientifically and clinically, the findings can inform targeted training and standardization to improve safety and consistency of PICC care in oncology settings.
Larsen EN, Wickins J, Marsh N et al. · Seminars in oncology nursing · (2026) · View on PubMed ↗ · Free PDF ↗
Rates, Timing and Correlates of Suicide in Norwegian Prisons: A 23-Year National Cohort Study.
This national cohort study examined suicide mortality in Norwegian prisons over 23 years (2000–2022) using linked registry data from the Norwegian Prison Release study (nPRIS). The key finding was that suicide timing relative to imprisonment and associations with sociodemographic, criminological, and clinical factors can be characterized across the incarceration period, identifying when risk is highest and which correlates matter. The clinical and public-health significance is that these temporal and risk-factor insights can guide targeted prevention strategies within correctional settings.
Bukten A, Mehlum L, Lokdam NT et al. · Archives of suicide research : official journal of the International Academy for Suicide Research · (2026) · View on PubMed ↗ · Free PDF ↗
Relative importance of weight gain among cardiometabolic risk factors in the development of metabolic dysfunction-associated steatotic liver disease: An observational study using large-scale health examination data.
This retrospective cohort study used large-scale health examination data to follow 7,687 individuals without steatotic liver disease over 5 years, assessing how baseline cardiometabolic risk factors and 5-year weight change (including BMI and waist circumference) predicted incident metabolic dysfunction-associated steatotic liver disease (MASLD). The key finding was that weight gain—particularly obesity-related indices such as BMI and waist circumference—had a relatively greater contribution to developing MASLD than other cardiometabolic risk factors, and the study identified a weight-gain threshold associated with increased MASLD risk. Scientifically and clinically, the results clarify which anthropometric changes most strongly drive MASLD onset and can inform targeted weight-management thresholds for prevention.
Sahara K, Yokoyama S, Ito T et al. · Internal medicine (Tokyo, Japan) · (2026) · View on PubMed ↗ · Free PDF ↗
Da Vinci® X™, Versius®, and Hugo™ RAS in minimally invasive robotic-assisted hysterectomy: the COMPAR-HYST prospective study.
This prospective single-center non-randomized COMPAR-HYST study compared three robotic platforms—da Vinci X (Intuitive Surgical), Versius (CMR Surgical), and Hugo RAS (Medtronic)—in consecutive adult women undergoing elective laparoscopic hysterectomy in 2024. Patients were assigned 1:1:1 based on same-day platform availability, and the study’s primary endpoint was an “optimal hysterectomy” composite performance outcome along with perioperative outcomes. The results are intended to inform comparative effectiveness and safety of current next-generation robotic systems for minimally invasive hysterectomy in routine clinical practice.
Garzon S, Landi S, Da Ros A et al. · Surgical endoscopy · (2026) · View on PubMed ↗ · Free PDF ↗
Correlation Between Computer-Assisted Ultrasonographic Parameters and Histological Findings in Glomerular Diseases: A Multivariate Ordinal Analysis.
This 2026 Journal of Clinical Ultrasound study used computer-assisted image analysis to correlate renal ultrasound and Doppler parameters (including cortical-to-liver/spleen echogenicity ratio, corticomedullary ratio [CMR], renal resistivity index [RRI], splenic resistivity index [SRI], and DI-RISK) with kidney biopsy histology across glomerular diseases. Using multivariate ordinal analysis, the ultrasound-derived quantitative metrics showed significant correlations with lupus nephritis activity and chronicity histological components. Scientifically, it supports objective, image-analysis–based ultrasound biomarkers as noninvasive surrogates for biopsy-defined renal pathology, potentially aiding monitoring and risk assessment in glomerular disease.
Araújo NC, da Silveira Rioja L, Suassuna JHR · Journal of clinical ultrasound : JCU · (2026) · View on PubMed ↗
Estimating the Effect of Hospital Admission on Health Care Outcomes and Spending Among Persons With Dementia : A Quasi-experimental Study.
This quasi-experimental instrumental variable study evaluated the effect of hospital admission on health outcomes and health care spending among Medicare fee-for-service beneficiaries aged ≥66 years with dementia who visited an emergency department (ED) in 2017–2019. Using emergency physicians’ admission propensity as the instrument, hospital admission was assessed for downstream impacts on patient outcomes and costs (specific results are not included in the truncated abstract). The findings are significant for care-transition policy, potentially informing strategies to reduce avoidable admissions and their harms in older adults with dementia.
Ikesu R, Mayeda ER, McGarry K et al. · Annals of internal medicine · (2026) · View on PubMed ↗
Generated automatically on June 15, 2026. Covers PubMed articles published June 08, 2026 – June 15, 2026. Summaries are AI-generated; always consult the original publication for clinical or research decisions.