What's New in Cardiac MRI? — June 17, 2026
AI-summarised digest of 64 PubMed articles on Cardiac MRI published in the last 7 days.
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What’s New in Cardiac MRI?
June 17, 2026 · 64 articles · 15 research themes · covering June 10, 2026 – June 17, 2026
Overview
This week’s digest is dominated by advances in cardiovascular imaging—especially cardiac MRI/CT quantification and the move toward more reproducible, standardized biomarkers. Multiple studies tackle methodological reliability (e.g., strain and stroke-volume/flow agreement, probabilistic segmentation uncertainty, and standardized left ventricular thrombus volume measurement), while others push technical frontiers such as free-breathing cine MRI for atrial fibrillation, 7T B1 shimming for consistent strain, and CT/DECT approaches that align with CMR scar references. Together, these efforts aim to reduce variability across scanners, protocols, and readers so imaging biomarkers can be used more confidently for prognosis and trial endpoints.
A second major theme is the rapid integration of AI into cardiology workflows—both for scalable detection (ECG-based hypertrophic cardiomyopathy screening) and for automated/interpretive tasks in imaging (parameter-efficient strain analysis, explainable AI for pre-reperfusion intramyocardial hemorrhage, and AI-informed characterization of LGE “granularity”). Several reviews also emphasize that AI is still often an assistive tool rather than a fully standalone diagnostic system, highlighting the need for standardization and careful validation.
Clinically, the articles span risk stratification and complex disease phenotyping: refined hemodynamic congestion staging with MRI, improved CMR-based discrimination of constrictive pericarditis, and multimodality approaches to thrombus/intracardiac masses (including rare congenital variants and mechanical complications misread as thrombus). Meanwhile, disease-specific reports underscore the value of multimodality imaging for uncommon etiologies—infectious/parasitic myocarditis and pericarditis, eosinophilic cardiac syndromes, and cancer-related cardiac metastasis—while oncology-adjacent studies connect cardiac remodeling metrics and imaging strategies to broader outcomes such as cancer risk and cardio-oncology capacity building.
Cardiac MRI/CT Quantification Methods & Standardization
Size-Resolved Microelectrical Effects of Fine Aerosol on Nocturnal Ozone: Evidence from Field Observations and Statistical Modeling.
This field observational and statistical modeling study investigated how particle electrical properties—specifically particle charge-to-mass ratio (CMR)—relate to nocturnal ozone (O3) enhancement in Xi’an during 2023–2025. Using generalized additive models (GAM), partial least squares structural equation modeling (PLS-SEM), and an interfacial contribution model, the study found associations between size-resolved aerosol electrical effects and nocturnal O3 variations under stable nocturnal conditions. The work is significant because it suggests particulate charge properties may be an underappreciated driver of nocturnal O3 chemistry beyond meteorological transport.
Wang Y, Zhang L, Li J et al. · Environmental research · (2026) · View on PubMed ↗
Agreement between ventricular stroke volumes and great vessel flow using cine and phase-contrast MRI in healthy subjects.
This study assessed agreement between ventricular stroke volumes and great-vessel forward flows measured by cine and phase-contrast MRI in 15 healthy volunteers. The key finding was that Bland–Altman analysis showed negative additive bias for several RV-related comparisons (RV–PA, RV–Ao, and RV–LV), with agreement quantified using intraclass correlation coefficients (ICC). Scientifically, it informs how reliably MRI-derived stroke volume and flow metrics can be used interchangeably in regurgitation quantification assumptions.
Kawaguchi A, Kawaguchi W, Hayashi M et al. · Radiological physics and technology · (2026) · View on PubMed ↗ · Free PDF ↗
Association of Subclinical Cardiac Remodeling With Incident Cancer in the MESA Cohort.
This study examined whether cardiac magnetic resonance imaging (CMR) measures of subclinical cardiac remodeling predict incident cancer in the Multi-Ethnic Study of Atherosclerosis (MESA) cohort. Using multivariable Cox proportional hazards models, the authors reported associations between specific CMR remodeling metrics and subsequent cancer occurrence across overall and sex-specific cancer endpoints. These findings suggest that early, imaging-detectable cardiac remodeling may serve as a biomarker linking subclinical cardiovascular changes to future cancer risk.
Cai X, White Q, Juarez J et al. · Journal of the American Heart Association · (2026) · View on PubMed ↗ · Free PDF ↗
Right Ventricular Strain Analysis with PET-derived Feature Tracking: Direct Comparison with Magnetic Resonance using Hybrid PET/MR.
This retrospective study evaluated feasibility of right ventricular (RV) global longitudinal strain quantification using a newly developed PET feature tracking technique, using magnetic resonance (MR) strain as the reference standard. In 123 consecutive patients undergoing rest 13N ammonia PET/MR, semi-automatic PET feature tracking (MATLAB-based) was compared directly with MR-derived RV strain metrics. If validated, PET-based RV strain could enable more sensitive assessment of subtle RV dysfunction in settings where PET is already performed.
Katahira M, Fukushima K, Ikeda A et al. · Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · (2026) · View on PubMed ↗
Free-Breathing Dynamic, Regularized, Adaptive Cluster Optimization (DRACO) Cine Cardiac MRI in Atrial Fibrillation.
This prospective study tailored the DRACO (dynamic regularized adaptive cluster optimization) cine cardiac MRI method for free-breathing imaging in patients with atrial fibrillation (AF) and assessed its ability to handle both cardiac and respiratory motion. In 30 participants (10 sinus rhythm and 20 AF) scanned at 3.0 T using bSSFP cine with ECG-gated segmented acquisition and real-time components, the authors evaluated the quality and quantifiability of DRACO-derived cine images under irregular rhythm conditions. If broadly reproducible, DRACO could improve cardiac MRI feasibility and measurement reliability in AF without requiring breath-holding.
Ming Z, Pogosyan A, Dong X et al. · Journal of magnetic resonance imaging : JMRI · (2026) · View on PubMed ↗
Parasitically coupled 16-port massive MIMO antenna for mmWave applications.
Researchers studied the design and performance of a compact 16-port parasitically coupled massive MIMO antenna for millimeter-wave (mmWave) applications, including selection of an optimal single-element design and replication to a 16-port array. The antenna was implemented to resonate at 40 GHz and uses triangular parasitic elements, a triangular feed-line element, and an impedance matching network with defected ground and stubs. Scientifically, the work provides a compact multiport antenna architecture suitable for high-frequency massive MIMO systems.
Mishra B, Sharma H, Misra NK et al. · Scientific reports · (2026) · View on PubMed ↗ · Free PDF ↗
The correlation of cardiovascular magnetic resonance imaging findings with clinical diagnoses and its acute impact on management changes in a regional Australian hospital.
In a retrospective single-center study of 111 adult acute cardiovascular patients in a regional Australian hospital, investigators assessed how cardiovascular magnetic resonance (CMR) findings correlated with clinical diagnoses and how CMR acutely changed management plans. The key finding was that CMR significantly improved diagnostic accuracy and led to measurable management changes after imaging, quantified using agreement statistics (Cohen’s kappa). Clinically, this supports CMR as an actionable diagnostic tool in acute care settings where initial diagnoses may be uncertain.
Tan C, Thanabalasingam V, Hiskens MI et al. · Medicine · (2026) · View on PubMed ↗ · Free PDF ↗
High resolution, 3D isotropic late gadolinium enhanced imaging for the quantification of left atrial fibrosis and post-ablation scarring.
Researchers prospectively studied 40 ablation-naïve atrial fibrillation (AF) patients (paroxysmal and persistent) and 20 healthy controls to evaluate a high-resolution 3D isotropic late gadolinium enhancement (LGE) Dixon CMR sequence for quantifying left atrial (LA) fibrosis and post-ablation scarring. The key finding was that the higher spatial resolution 3D isotropic LGE approach better characterizes the thin LA wall for fibrosis quantification compared with conventional lower-resolution LGE methods. Scientifically and clinically, this provides improved imaging reference capability for atrial myopathy assessment and may enhance evaluation of AF substrate and treatment effects.
Fenski M, Hickstein R, Krüger LD et al. · European heart journal. Imaging methods and practice · (2026) · View on PubMed ↗ · Free PDF ↗
Nurses’ Clinical Decision-Making During Peripherally Inserted Central Catheter Dressing Application and Removal: A Qualitative Study.
This qualitative study examined how nurses in cancer care make clinical decisions when applying and removing peripherally inserted central catheter (PICC) dressings and securement devices in adult and pediatric quaternary hospital wards in Brisbane, Australia. Using a Think Aloud method with registered nurses and Framework Analysis mapped to Dual Process Theory, the study characterized the reasoning used across four dressing/securement combinations. The results are significant for improving PICC dressing protocols and training by clarifying the cognitive processes behind safe, consistent catheter care.
Larsen EN, Wickins J, Marsh N et al. · Seminars in oncology nursing · (2026) · View on PubMed ↗ · Free PDF ↗
Segmental strain in chronic ischemic cardiomyopathy: clarifying the role of multiple-comparison adjustment and the clinical interpretation of limits of agreement.
This correspondence studied segmental LV longitudinal strain in chronic ischemic cardiomyopathy by addressing methodological issues around multiple-comparison adjustment and interpreting limits of agreement. The key finding is that segment-level comparisons and agreement limits should be interpreted cautiously, especially when comparing feature-tracking CMR and 2D speckle-tracking echocardiography for individual or longitudinal use. The scientific significance is improved statistical rigor and clinical interpretation of strain thresholds when using intermodality strain measurements that are not fully interchangeable.
Malik MMUD, Jayaswal RP · Journal of cardiovascular imaging · (2026) · View on PubMed ↗ · Free PDF ↗
Clinical Importance of All the Characteristics of Late Gadolinium Enhancement from Acquisition to Expert and Artificial Intelligence Analysis: State-of-the-Art.
This state-of-the-art review studied how late gadolinium enhancement (LGE) “granularity” (location, extent, and pattern) in cardiovascular magnetic resonance is influenced by acquisition parameters (contrast media choice, post-processing) and by interpretation methods including expert reading and artificial intelligence (AI). It found that beyond simple presence/extent of LGE, detailed characterization of LGE features improves insight into myocardial pathophysiology and can affect diagnostic and prognostic performance depending on the workflow. Scientifically and clinically, standardizing acquisition and analysis of LGE granularity—especially when using AI—could improve reproducibility and risk prediction across cardiac diseases.
Florence J, Unger A, Gonçalves T et al. · Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · (2026) · View on PubMed ↗ · Free PDF ↗
The Feasibility of Low Contrast Dose Dual-energy CT for Quantifying Myocardial Focal Scar via Extracellular Volume Fraction.
This prospective study evaluated whether low-contrast-dose dual-energy CT (DECT) using extracellular volume fraction (ECV) can quantify myocardial focal scar (MFS) compared with cardiac MRI (CMR) late gadolinium enhancement (LGE) and CMR ECV. In 33 patients with confirmed old myocardial infarction, DECT-LIE-derived ECV showed quantitative agreement with CMR-LGE-defined MFS and remote myocardium at matched slices/segments, supporting feasibility of scar quantification with reduced contrast dose. This is significant because it could lower contrast exposure while providing CT-based myocardial scar assessment aligned with CMR reference standards.
Chen F, Jia T, Luo L et al. · The British journal of radiology · (2026) · View on PubMed ↗
Relative importance of weight gain among cardiometabolic risk factors in the development of metabolic dysfunction-associated steatotic liver disease: An observational study using large-scale health examination data.
This retrospective cohort study of 7,687 adults without baseline steatotic liver disease used large-scale health examination data to assess how cardiometabolic risk factors—especially weight gain–related obesity indices such as BMI and waist circumference—predict incident metabolic dysfunction-associated steatotic liver disease (MASLD) over 5 years. Greater weight gain and higher obesity-related measures showed the strongest association with developing MASLD compared with other cardiometabolic risk factors, and the study identified a weight-gain threshold linked to increased risk. These findings support using BMI/waist change as practical risk stratifiers for MASLD prevention and for targeting weight management in cardiometabolic care.
Sahara K, Yokoyama S, Ito T et al. · Internal medicine (Tokyo, Japan) · (2026) · View on PubMed ↗ · Free PDF ↗
Da Vinci® X™, Versius®, and Hugo™ RAS in minimally invasive robotic-assisted hysterectomy: the COMPAR-HYST prospective study.
This prospective COMPAR-HYST study compared three robotic surgical platforms—da Vinci X™, Versius®, and Hugo™ RAS—for minimally invasive robotic-assisted hysterectomy in consecutive adult women scheduled for elective laparoscopic hysterectomy in 2024. The study’s main outcome was optimal hysterectomy performance (a composite measure) along with perioperative outcomes across platforms, using non-randomized 1:1:1 assignment based on day-of-surgery availability. The results are intended to inform platform selection by linking robotic system choice to measurable surgical performance and perioperative safety in routine hysterectomy practice.
Garzon S, Landi S, Da Ros A et al. · Surgical endoscopy · (2026) · View on PubMed ↗ · Free PDF ↗
Correlation Between Computer-Assisted Ultrasonographic Parameters and Histological Findings in Glomerular Diseases: A Multivariate Ordinal Analysis.
This Journal of Clinical Ultrasound study correlated computer-assisted renal ultrasonographic and Doppler parameters with kidney biopsy histology in patients with glomerular diseases. Using multivariate ordinal analysis, it assessed how quantitative measures such as cortical-to-liver/spleen echogenicity ratio, corticomedullary ratio (CMR), renal resistivity index (RRI), splenic resistivity index (SRI), and DI-RISK relate to lupus nephritis activity and chronicity indices. Clinically, it supports the use of standardized, image-analysis–based ultrasound metrics as noninvasive surrogates for biopsy-determined glomerular injury severity.
Araújo NC, da Silveira Rioja L, Suassuna JHR · Journal of clinical ultrasound : JCU · (2026) · View on PubMed ↗
AI for Cardiac Imaging & Biomarker Automation
Advances in artificial intelligence for the evaluation of mitral regurgitation.
This narrative review summarized advances in artificial intelligence across the mitral regurgitation (MR) diagnostic pathway, including upstream screening and multimodality imaging interpretation. The key finding was that AI approaches such as digital stethoscopes and deep learning ECG models are increasingly used for scalable enrichment and risk stratification, but many are not yet standalone diagnostic tools. The clinical significance is that it maps current capabilities and gaps for integrating AI into MR evaluation to reduce time burden and interobserver variability.
Sanchez AA, Sadeghpour A, Asch FM · Current opinion in cardiology · (2026) · View on PubMed ↗
Modeling Aleatoric Uncertainty in Cardiac MRI Segmentation: Probabilistic Detection and Contour Regression.
This methodological study investigated probabilistic cardiac MRI segmentation that models aleatoric uncertainty for more reliable biomarker estimation of left and right ventricular ejection fraction (LVEF/RVEF). The key finding is that uncertainty-aware segmentation aims to produce calibrated biomarker variance for individual patients rather than only high average segmentation accuracy at the population level. Scientifically, this supports more trustworthy AI-derived cardiac biomarkers by explicitly addressing annotation variability and anatomical ambiguity through probabilistic contour regression.
Zhao Y, Zhang Y, Tourais J et al. · IEEE transactions on medical imaging · (2026) · View on PubMed ↗ · Free PDF ↗
Parameter-efficient adaptation of foundational models for automated myocardial strain analysis.
This study developed and tested a parameter-efficient deep learning approach for automated myocardial strain analysis that adapts foundational models across imaging domains. The key finding was that CardiacSAM (Segment Anything Model fine-tuned with Low-Rank Adaptation/LoRA) combined with uniGradICON for myocardial motion estimation enabled robust cross-scanner myocardial segmentation and strain estimation with minimal additional data for adaptation. This is significant because it reduces the data burden for deploying automated strain analysis in new institutions, improving generalizability for clinical cardiac imaging workflows.
Bernardo A, Mato G, Calandrelli M et al. · Biomedical physics & engineering express · (2026) · View on PubMed ↗ · Free PDF ↗
Cardiac Imaging for Valvular Disease (MR/AS/AR)
Design and Rationale of the REVEAL PET Study: A Study of 124I-evuzamitide to Diagnose Cardiac Amyloidosis.
This phase 3, multicenter, open-label, single-arm REVEAL PET study was designed to test whether 124I-evuzamitide PET/CT can diagnose cardiac amyloidosis in adults being evaluated for suspected disease. The trial rationale is that 124I-evuzamitide is a fibril-targeting radiotracer binding hypersulfated heparan sulfate glycans present across amyloid subtypes, and the study will quantify diagnostic performance at 18 U.S. centers. The results could establish a standardized, noninvasive imaging approach to improve detection of cardiac amyloidosis beyond current clinical pathways.
Dorbala S, Maurer MS, Cuddy SAM et al. · Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · (2026) · View on PubMed ↗
Quantification of mitral regurgitation: from traditional methods to artificial intelligence.
This review summarized how mitral regurgitation (MR) quantification has evolved from traditional echocardiographic geometric methods to artificial intelligence approaches. It reports that machine-learning methods can quantify regurgitant flow across systole, better handle eccentric or multiple jets, and show favorable agreement with cardiac magnetic resonance, with additional AI models capable of grading MR directly from echocardiographic clips. Improved AI-based MR quantification could reduce measurement bias and increase accuracy for clinical decision-making.
Cho K, Su J, Bonnefous O et al. · Cardiovascular ultrasound · (2026) · View on PubMed ↗ · Free PDF ↗
Aortic Stenosis Progression: Lessons from Multimodality Imaging.
This review studied the progression of calcific aortic stenosis in the aging population and synthesized evidence on how multiple signaling pathways drive the transition from sclerotic to severe disease. It found that multimodality imaging—echocardiography, cardiac magnetic resonance, cardiac computed tomography, and nuclear imaging—can assess both valve calcification and metabolic activity to quantify severity and track progression. The review is clinically important because these imaging “checkpoints” may serve as targets for research trials aiming to halt or slow aortic stenosis progression.
Jain R, Padang R, Postalian A et al. · Mayo Clinic proceedings · (2026) · View on PubMed ↗
Cardiovascular magnetic resonance reclassification of aortic regurgitation after transcatheter aortic valve implantation: A COMPARE-TAVI 1 substudy.
This COMPARE-TAVI 1 substudy studied how cardiovascular magnetic resonance (CMR) reclassifies aortic regurgitation (AR) after transcatheter aortic valve implantation (TAVI) compared with transthoracic echocardiography (TTE) using VARC-3 criteria. In randomized patients receiving Sapien 3/Sapien 3 Ultra or Myval/Myval Octacor valves, CMR provided direct quantification of regurgitant flow and was used to evaluate whether TTE’s semiquantitative, operator-dependent measures align with CMR findings. The significance is that CMR may improve post-TAVI AR assessment and reduce misclassification that could affect clinical management and trial endpoints.
Pedersen AAU, Pedersen ALD, Mogensen NSB et al. · Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · (2026) · View on PubMed ↗ · Free PDF ↗
Impact of Concomitant Mitral Regurgitation in Moderate Aortic Stenosis: Assessment of Remodeling and Clinical Outcomes.
This cardiac magnetic resonance (CMR)-based observational study evaluated 742 patients with moderate aortic stenosis (AS) stratified by mitral regurgitation (MR) burden to determine effects on cardiac remodeling and clinical outcomes, comparing moderate AS with isolated severe AS. Concomitant MR in patients with moderate AS was associated with worse remodeling and poorer clinical outcomes than moderate AS without significant MR (and with patterns approaching those seen in severe AS). Clinically, this suggests that MR burden should be incorporated into risk assessment and management decisions for patients who do not meet single-lesion intervention thresholds.
Gabr EM, Xiao M, Saeed M et al. · JACC. Cardiovascular imaging · (2026) · View on PubMed ↗
Cardiac Imaging for Thrombus, Emboli, and Intracardiac Masses
A simplified geometric CMR method for reproducible quantification of left ventricular thrombus volume : Left Ventricular thrombus: a standardized measurement method.
This post-hoc analysis assessed a simplified geometric CMR method for standardized, reproducible quantification of left ventricular thrombus (LVT) volume in patients imaged 5 days after reperfusion for ST-segment elevation myocardial infarction from the COVERT-MI trial. The key finding was that the geometric approach was feasible and demonstrated reproducibility for LVT volume measurement. Standardized LVT quantification could improve consistency across studies and help clarify how thrombus characteristics relate to clinical evolution and embolic risk.
Fuzeau A, Angoulvant D, Pucheux J et al. · The international journal of cardiovascular imaging · (2026) · View on PubMed ↗ · Free PDF ↗
Rates, Timing and Correlates of Suicide in Norwegian Prisons: A 23-Year National Cohort Study.
This national cohort study examined suicide timing and correlates in Norwegian prisons across a 23-year period using linked registry data for all incarcerated individuals from 1.1.2000 to 31.12.2022. The key finding (as framed by the study objective) is that suicide mortality can be analyzed by imprisonment timing and associated with sociodemographic, criminological, and clinical factors within this high-risk population. The clinical/public health significance is that identifying when and for whom suicide risk is highest can inform targeted prevention strategies in correctional settings.
Bukten A, Mehlum L, Lokdam NT et al. · Archives of suicide research : official journal of the International Academy for Suicide Research · (2026) · View on PubMed ↗ · Free PDF ↗
Intramyocardial Dissecting Hematoma After Myocardial Infarction Diagnosed by Multimodality Imaging.
This JACC case report studied a rare mechanical complication—intramyocardial dissection after myocardial infarction—in a 47-year-old man initially misdiagnosed with left ventricular (LV) thrombus. Despite anticoagulation, the patient deteriorated with cardiogenic shock and ventricular tachycardia, and cardiac magnetic resonance revealed extensive anterior transmural infarction with a dissecting intramyocardial cavity consistent with intramyocardial dissection. The significance is that multimodality imaging, particularly CMR, can distinguish intramyocardial dissection from LV thrombus to guide urgent management when anticoagulation fails.
Borg BC, Josephs C, Ghincea C et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗
Congenital Absence of the Left Atrial Appendage in Atrial Fibrillation With Gastrointestinal Bleeding.
This JACC Case Reports report describes a 78-year-old man with permanent atrial fibrillation (AF) and recurrent obscure gastrointestinal bleeding in whom congenital absence of the left atrial appendage (LAA) was evaluated. Transesophageal echocardiography and cardiac magnetic resonance imaging confirmed congenital LAA absence without atrial thrombus, supporting a tailored approach given the patient’s high bleeding risk. The case highlights how rare LAA anatomy variants can influence thromboembolic risk assessment and anticoagulation/left-atrial-appendage occlusion decision-making in AF.
Nashtar MA, Steinmetz M, Trippe J et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗
Percutaneous Aspiration Thrombectomy for a Large Right Atrial Thrombus in a Critically Ill Patient.
This JACC Case Reports article describes a 52-year-old dialysis-dependent woman with type 1 diabetes and prior pancreas and kidney transplantation who developed a large right atrial (RA) thrombus (4×2 cm) associated with catheter-related sepsis. Using percutaneous aspiration thrombectomy with the FlowTriever system, clinicians achieved near-complete thrombus removal, with residual thrombus treated using systemic anticoagulation. The case supports percutaneous aspiration thrombectomy as a feasible alternative to surgery in critically ill patients with RA thrombi when operative risk is prohibitive.
Nashtar MA, Steinmetz M, Schnitzbauer A et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗
Cardiac MRI/Imaging in Acute Coronary Syndromes & Post-MI Risk
Inhibition of late sodium current (INa) to prevent coronary MICROvascular dysfunction in patients presenting with ST-elevation myocardial infarction and multivessel disease: A phase IIb multicenter, randomized, controlled and open label study (INaMICRON).
This phase IIb multicenter randomized open-label trial (INaMICRON) studied whether early inhibition of the late sodium current with ranolazine, added to guideline-directed medical therapy, can prevent coronary microvascular dysfunction (CMD) in adults presenting with ST-elevation myocardial infarction (STEMI) who underwent successful primary PCI and had at least one significant non-culprit lesion. The trial’s key finding is the study design and rationale that ranolazine-mediated late INa inhibition is expected to favorably modulate microvascular function during the early post-infarction period compared with standard therapy. If confirmed, this would provide a targeted pharmacologic strategy to reduce persistent ischemia and impaired recovery driven by residual CMD after STEMI.
Di Serafino L, Ciaramella L, De Rosa S et al. · International journal of cardiology · (2026) · View on PubMed ↗ · Free PDF ↗
Predicting Intramyocardial Hemorrhage Before Reperfusion in STEMI Patients With Intrinsically Explainable Artificial Intelligence.
This JACC Advances study developed an intrinsically explainable AI model to predict intramyocardial hemorrhage (IMH) before reperfusion in patients with ST-elevation myocardial infarction (STEMI) using data from the MIRON-PREDICT clinical study (288 patients; 252 development, 36 validation). The key finding was that the explainable AI approach produced a bedside-usable pre-reperfusion IMH prediction score using pre-intervention electrocardiographic, angiographic, and clinical variables. Clinically, this enables earlier identification of patients likely to have IMH—an adverse prognostic feature—potentially guiding risk-adapted management before PCI.
Youssef K, Vora KP, Gupta R et al. · JACC. Advances · (2026) · View on PubMed ↗ · Free PDF ↗
Sudden Cardiac Death (SCD) Risk Stratification & ICD Decision-Making
A Narrative Review of Risk Assessment Approaches for Implantable Defibrillator Therapy to Prevent Sudden Cardiac Death in Acute Myocardial Infarction.
This narrative review evaluated risk assessment strategies for implantable defibrillator (ICD) therapy to prevent sudden cardiac death (SCD) in the setting of acute myocardial infarction. It emphasizes that while ICD decisions have historically relied heavily on left ventricular ejection fraction (LVEF), LVEF-based models have limited sensitivity and specificity, motivating more comprehensive approaches including advanced cardiac magnetic resonance–based modalities. The review is clinically significant because it frames how next-generation, multimodal risk stratification may better identify patients who benefit from ICD therapy after STEMI.
Kakavand N, Shojaei Y, Sadri M et al. · Cardiology research and practice · (2026) · View on PubMed ↗
Sinus Node Dysfunction in Takotsubo Syndrome: An Uncommon Presentation.
This case report studied a 68-year-old patient with Takotsubo syndrome to evaluate conduction system involvement, specifically sinus node dysfunction (SND). After coronary angiography excluded obstructive coronary disease and cardiac magnetic resonance confirmed stress cardiomyopathy, the patient developed SND during hospitalization that persisted despite complete recovery of left ventricular systolic function, ultimately requiring permanent pacemaker implantation. Clinically, it shows that although Takotsubo cardiomyopathy is typically reversible, clinically significant and persistent sinus node dysfunction can occur and may necessitate durable pacing.
Zakynthinos GE, Kalogeras K, Vlachojannis GJ et al. · JACC. Case reports · (2026) · 1 citations · View on PubMed ↗ · Free PDF ↗
Hypertrophic Cardiomyopathy (HCM) Prognosis, Phenotypes, and Screening
Artificial Intelligence for the Detection of Hypertrophic Cardiomyopathy From Standard Electrocardiogram.
This diagnostic study evaluated an artificial intelligence algorithm (Viz HCM, Viz.ai) for detecting hypertrophic cardiomyopathy (HCM) from standard 12-lead ECGs in patients with suspected HCM and in controls without cardiomyopathy. Among 150 analyzable ECGs with HCM confirmed by physician review and cardiac MRI (ground truth) and 83 control patients, the AI algorithm’s performance and predictors of correct classification were assessed against the cMRI-confirmed diagnosis. The clinical significance is that ECG-based AI could enable earlier HCM detection and reduce avoidable risk from delayed diagnosis.
Park J, Kermanshahchi J, Love CJ et al. · JACC. Advances · (2026) · View on PubMed ↗
Left Atrial Reservoir Strain for Predicting Progression to End-Stage in Hypertrophic Cardiomyopathy.
This cohort study evaluated whether left atrial reservoir strain measured by echocardiography predicts progression to end-stage hypertrophic cardiomyopathy (HCM) in 925 HCM patients followed for a median of 6.5 years, with a CMR subcohort of 491 patients. The key finding was that left atrial reservoir strain served as a prognostic factor for progression to end-stage HCM, defined as LVEF <50% without reversible causes. This is clinically significant because it identifies a potentially actionable echocardiographic marker to stratify risk for deterioration in HCM.
Kwak S, Jeong MH, Park CS et al. · European heart journal. Cardiovascular Imaging · (2026) · View on PubMed ↗
Apical Hypertrophic Cardiomyopathy and Elite-Level Sports: A 12-Year Follow-Up Case.
A single elite-level athlete with apical hypertrophic cardiomyopathy (aHCM) was followed for 12 years to assess how long-term participation in elite sports affected cardiac morphology and fibrosis progression. The key finding was that elite sports participation from ages 17 to 31 did not lead to adverse morphologic changes or progression of apical fibrosis, even after stopping professional sports. Clinically, this case supports that aHCM may have a distinct sports interaction profile and highlights the importance of phenotype-specific risk assessment rather than assuming uniform risk across hypertrophic cardiomyopathy subtypes.
Thio Q, van Hattum J, Nijland F et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗
Prognostic Value of MRI-Based Left Ventricular Trabecular Complexity for Sudden Cardiac Death in Hypertrophic Cardiomyopathy.
This prospective study evaluated whether left ventricular (LV) myocardial trabecular complexity quantified by fractal dimension (FD) on 3T cardiac MRI (steady-state free precession cine) predicts sudden cardiac death (SCD) in 835 hypertrophic cardiomyopathy (HCM) patients and examined associations with sarcomere gene variants. The key finding was that higher LV trabecular complexity (FD) measured on MRI was validated as a prognostic marker for SCD risk and related to underlying sarcomere genetic background. This supports using MRI-based trabecular complexity as an additional, noninvasive tool for early SCD risk stratification in HCM alongside genetic information.
Zhang J, Yu M, Pu L et al. · Journal of magnetic resonance imaging : JMRI · (2026) · 1 citations · View on PubMed ↗
Puberty-Associated Emergence of Hypertrophic Cardiomyopathy: When Genetics Meets Growth.
This JACC Case Reports article presents a 13-year-old boy with a strong family history of hypertrophic obstructive cardiomyopathy in whom hypertrophic cardiomyopathy (HCM) phenotypic expression emerged during puberty. The report illustrates genotype-positive status with delayed phenotypic conversion coinciding with growth/puberty-related changes, emphasizing the role of developmental modifiers in HCM expression. Scientifically, it underscores the need for longitudinal surveillance of genotype-positive children through adolescence to detect late-onset disease manifestation.
Mashiah G, Schamroth N, Yaeger-Yarom G et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗
Arrhythmogenic Cardiomyopathy & Athlete Sudden Death
Outcomes From the Multicenter ACCRU-LY-1804/CARiBOU TRIAL (Cytarabine, Acalabrutinib and Rituximab Integrated With Bortezomib-Based Outpatient Therapy) in 1st Line Mantle Cell Lymphoma.
This phase 2 multicenter ACCRU-LY-1804/CARiBOU trial studied first-line cytarabine, acalabrutinib, rituximab, and bortezomib-based outpatient therapy in previously untreated mantle cell lymphoma (MCL) patients, with complete metabolic response (CMR) as the primary endpoint. The trial evaluated safety/feasibility outcomes (including stem cell collection and rates proceeding to ASCT) and efficacy endpoints (PFS and OS) for this multitargeted regimen using alternating VR-CAP and R-cytarabine plus continuous acalabrutinib. The results are clinically significant for defining an effective, outpatient-capable induction strategy aimed at durable complete responses in MCL.
Smith SD, Sundaram S, Giri S et al. · American journal of hematology · (2026) · View on PubMed ↗
Heart Failure, Congestion, and Hemodynamic Phenotyping
Primary Aldosteronism: CXCR4- and FAP-Targeted PET/MR for Adrenal-Cardiac Axis.
This study investigated the adrenal–cardiac axis in primary aldosteronism (PA) by integrating CXCR4-targeted 68Ga-Pentixafor PET/MR and FAP-targeted 68Ga-FAPI-04 PET/cardiac MRI in 82 participants (40 with PA including aldosterone-producing adenoma and idiopathic hyperaldosteronism, plus essential hypertension controls). The key finding was that in vivo PET/MR signals reflecting CXCR4-associated inflammatory activity and FAP-associated fibroblast activation in the adrenal-cardiac axis were measurable and linked to myocardial remodeling processes in PA. Scientifically, it provides mechanistic imaging evidence connecting adrenocortical activity to myocardial fibrosis pathways, potentially enabling targeted risk assessment beyond hemodynamics.
Ding J, Wang K, Song J et al. · Circulation. Cardiovascular imaging · (2026) · View on PubMed ↗
Cardiovascular effects of metyrapone treatment in patients with mild autonomous cortisol secretion: a secondary analysis.
This secondary analysis studied cardiovascular effects of cortisol-lowering therapy with metyrapone in 15 patients with mild autonomous cortisol secretion (MACS) before and after 12 weeks of evening dosing (500 mg at 6 p.m. and 250 mg at 10 p.m.). The key finding was that metyrapone treatment altered cardiovascular parameters related to blood pressure regulation, cardiac fat depots, and cardiac function/morphology compared with baseline after treatment. Clinically, these results support the concept that reducing cortisol excess can improve cardiovascular risk factors and cardiac phenotype in MACS patients.
Niziolek H, Just I, Baumgartner C et al. · The Journal of clinical endocrinology and metabolism · (2026) · View on PubMed ↗ · Free PDF ↗
MRI staging of haemodynamic congestion and clinical outcomes.
This European Radiology study evaluated cardiovascular magnetic resonance (MRI)–derived hemodynamic congestion markers—MRI-wedge pressure and pulmonary blood volume index (PBVi)—and their prognostic value for clinical outcomes. Patients were categorized into four MRI hemodynamic stages (normal profile, isolated volume overload, isolated pressure overload, combined overload), and the MRI markers were assessed for association with non-invasive indicators of myocardial fibrosis. The scientific significance is that MRI-based staging of filling pressure and pulmonary blood volume may improve risk stratification and connect congestion phenotypes to fibrotic remodeling without invasive catheterization.
Mantini C, Sorella A, Falco D et al. · European radiology · (2026) · View on PubMed ↗ · Free PDF ↗
Congenital Heart Disease & Complex Surgical Planning
Filling the Gaps: Generating 4D Dense Cardiac Anatomy from Sparse CMR for Enhanced Tetralogy of Fallot Assessment.
This study developed and validated a deep learning pipeline to generate 4D dense cardiac anatomy for repaired tetralogy of Fallot (rToF) by reconstructing dense 3D four-chamber anatomy from sparse CMR-like slices, using CT-derived isotropic 3D whole-heart segmentations for training. The key finding was that CT-trained deep learning can bridge the gap between clinically accessible CMR (with sparse anisotropic slices and motion artifacts) and CT’s spatial resolution to improve comprehensive anatomical assessment in rToF. This is scientifically and clinically significant because it could enhance preoperative/postoperative rToF evaluation without requiring CT for every patient.
Mauger C, Deng Y, Xu Y et al. · Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · (2026) · View on PubMed ↗
Evaluation of an unbalanced right dominant atrioventricular canal with a single 4D flow dataset.
This Journal of Cardiothoracic Surgery case report describes pre-operative imaging for a pediatric patient with an unbalanced, right-dominant atrioventricular (AV) canal using a novel cardiac MRI approach based on a single 4D flow dataset. The technique enabled accurate assessment of ventricular volumes and AV valve sizes, which informed the decision toward single-ventricle palliation rather than biventricular repair. The report suggests that streamlined 4D flow MRI acquisition can improve surgical planning in complex congenital heart disease.
Ream S, Schoeneberg L, King W · Journal of cardiothoracic surgery · (2026) · View on PubMed ↗ · Free PDF ↗
Right Heart Disease, RV Remodeling, and Shunt Physiology
Impact of systemic-to-pulmonary artery shunt embolization on right heart hemodynamics in patients with bronchiectasis.
Patients with bronchiectasis complicated by systemic-to-pulmonary artery shunts (SPS) were studied to determine whether right heart hemodynamics improve after SPS embolization, using right heart catheterization and (in those who tolerated it) cardiac magnetic resonance imaging before and within 24–48 hours after embolization. The key finding was that SPS embolization led to measurable changes in right heart hemodynamic parameters (including stroke volume, cardiac index/output, pulmonary artery pressure, pulmonary artery wedge pressure, and shunt oxygen saturation) shortly after the procedure. This supports SPS embolization as a potentially effective intervention for improving cardiopulmonary hemodynamics in bronchiectasis patients with shunt physiology.
Wu H, Jiang F, Guo L et al. · Journal of vascular and interventional radiology : JVIR · (2026) · View on PubMed ↗
Right Ventricular Remodeling in Repaired Tetralogy of Fallot: Imaging, Arrhythmia Risk, and Timing of Pulmonary Valve Replacement.
This review studied right ventricular (RV) remodeling after repaired tetralogy of Fallot (rTOF) in relation to cardiac magnetic resonance/imaging findings, arrhythmia risk, and the timing of pulmonary valve replacement in repaired TOF patients. It highlights that chronic pulmonary regurgitation, residual RV outflow tract obstruction, myocardial fibrosis, and electromechanical dyssynchrony drive a dynamic remodeling process characterized by RV dilatation, declining systolic/diastolic function, altered interventricular interaction, and formation of arrhythmogenic substrate. Clinically, these mechanisms support imaging- and electrophysiology-informed risk stratification and more timely pulmonary valve replacement to mitigate progression to heart failure and ventricular arrhythmias.
Fatima H, Akram MB, Sher A et al. · Cardiology in review · (2026) · View on PubMed ↗
Flow-Driven Right-to-Left Shunting Through the Patent Foramen Ovale Causing Hypoxemia and Embolism in a Partial Uhl Anomaly.
This case report studied a 49-year-old woman with partial Uhl anomaly and hypoxemia/embolism to determine how a patent foramen ovale (PFO) contributed to right-to-left shunting. Multimodality imaging showed diffuse right ventricular myocardial thinning with global systolic dysfunction and torrential functional tricuspid regurgitation, and despite normal right-sided pressures, a permanent flow-driven right-to-left shunt through the PFO caused hypoxemia and embolic events. Clinically, it highlights that in rare congenital right-sided failure states, non-pressure-dependent flow redirection across a PFO can drive shunt physiology and stroke risk even without elevated right atrial pressures.
Laboratto LE, Vannoni G, Nieto G et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗
Right Ventricular Apical Hypoplasia With a Novel Morphologic Presentation: The “Christmas Hat” Sign.
This case report studied a 9-year-old boy with congenital right ventricular (RV) apical hypoplasia to characterize a novel morphology. Multimodal imaging showed a severely hypoplastic, dysplastic RV with lobulated contours, and cardiac magnetic resonance demonstrated compensatory “Christmas hat” morphology in which the left ventricular apex was elongated and projected rightward. Scientifically, it expands the phenotypic spectrum of RV apical hypoplasia and supports cardiac MRI as a key technique for defining distinctive ventricular configurations.
Meléndez-Ramírez G, Patrón-Chi SA, Figueroa-Galván FS et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗
Pericardial Disease (Constrictive/Pericarditis/Effusion)
Left ventricular strain and hemodynamic forces from cine CMR for detecting constrictive physiology in pericarditis.
Patients with CMR-confirmed pericarditis were retrospectively analyzed using cine CMR to compute left ventricular strain and hemodynamic forces (HDF) to noninvasively distinguish constrictive physiology (CP) from non-constrictive physiology (NCP). The key finding was that cine-based strain metrics (including global longitudinal and circumferential strain) combined with HDF analysis improved diagnostic discrimination of CP versus NCP compared with largely qualitative CMR assessment. This is significant because it supports a more quantitative, noninvasive CMR approach for timely identification of constrictive physiology in pericarditis.
Vollbrecht TM, Proff A, Juraschitz S et al. · Insights into imaging · (2026) · View on PubMed ↗ · Free PDF ↗
Constrictive Pericarditis and Bilateral Pleural Effusions Unmasked in an HLA-B27 Positive Patient.
This case report studied constrictive pericarditis in a 40-year-old man who was HLA-B27 positive and presented with progressive dyspnea, fevers, and cough. The patient’s acute pericarditis progressed to constrictive physiology and, after failure of medical therapy, radical pericardiectomy led to symptom resolution. The report highlights a potential (previously underdescribed) association between HLA-B27–related disease and constrictive pericarditis, supporting consideration of autoimmune/spondyloarthropathy pathways in unexplained CP.
Villalonga M, Al-Dalakta A, El Roumi J et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗
Myocarditis and Infectious/Parasitic Cardiac Involvement
Hemorrhagic Eosinophilic Pericardial Effusion Associated With Probable Sparganosis.
A 25-year-old man with hemorrhagic eosinophilic pericardial effusion after ingesting undercooked frog meat was investigated for probable sparganosis using extensive diagnostic testing including cardiac magnetic resonance imaging, PET/CT, and next-generation sequencing. The study concluded that sparganosis was the most likely cause after repeated cultures, cytology, imaging, and molecular testing failed to identify an alternative etiology. The clinical significance is that sparganosis should be considered in eosinophilic hemorrhagic pericardial effusion when exposure history and eosinophilia/IgE strongly suggest helminth infection.
Zhu Y, Wang D, Wu Y et al. · International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · (2026) · View on PubMed ↗ · Free PDF ↗
Cardiac function and myocardial strain analysis at 7T using B1 shimming in comparison to 3T magnetic resonance imaging.
Ten volunteers underwent cardiac MRI cine imaging at 3T and 7T to compare myocardial volumetric and strain measurements using B1 shimming workflows, including acquisition of B1 maps at 7T to compute a single B1 phase-shim vector for the entire exam. The key finding was that B1 shimming enabled more consistent image quality at 7T and allowed comparison of strain parameters (long- and short-axis) against 3T reference measurements. Scientifically, this advances technical feasibility for quantitative cardiac strain at ultra-high field (7T) by mitigating transmit B1 heterogeneity.
Jung B, Hundertmark M, Peters AA et al. · The international journal of cardiovascular imaging · (2026) · View on PubMed ↗ · Free PDF ↗
Myocardial tuberculosis: a diagnostic challenge illustrated by two cases and review of contemporary management.
Two patients with myocardial tuberculosis—one with disseminated disease and one with isolated myocardial involvement—were studied alongside a review of contemporary management, with both receiving first-line anti-tuberculosis therapy (and one receiving corticosteroids and therapeutic anticoagulation). The key finding was that myocardial tuberculosis can present with variable and misleading clinical/radiologic features, yet outcomes were favorable with appropriate anti-tuberculosis treatment. Clinically, the article emphasizes considering myocardial tuberculosis in the differential diagnosis of myocarditis-like presentations, especially when standard diagnoses are not definitive.
Tremouilhac EM, Richaud C, Tresorier R et al. · The international journal of cardiovascular imaging · (2026) · View on PubMed ↗ · Free PDF ↗
Amazonian toxoplasmosis complicated by severe hypoxemic pneumonia and myopericarditis in an immunocompetent adult.
This BMC Infectious Diseases case report describes Amazonian toxoplasmosis in an immunocompetent adult complicated by severe hypoxemic pneumonia and myopericarditis. The key finding is documented cardiac involvement (myopericarditis) in a previously healthy young adult, emphasizing that cardiac abnormalities may be clinically silent and underdiagnosed early. The report is significant because it raises awareness that severe toxoplasmosis can involve the heart even without immunosuppression, guiding clinicians to consider cardiac evaluation when symptoms are severe.
Fréville B, Herrebrecht C, Samawak C et al. · BMC infectious diseases · (2026) · View on PubMed ↗ · Free PDF ↗
Isolated Cardiac Hydatid Disease Presenting as Ventricular Remodeling and Tamponade.
This case report examined a 16-year-old woman with isolated cardiac hydatid (Echinococcus) disease presenting with ventricular remodeling and cardiac tamponade. Multimodality imaging identified a large intact pericardial hydatid cyst with adjacent myocardial thinning, concentric hypertrophy of uninvolved left ventricular segments, active pericarditis, and pericardial effusion producing tamponade physiology. The report is significant because it documents an exceptionally rare echinococcal presentation where pericardial involvement can directly remodel myocardium and cause life-threatening tamponade.
Yousuf Q, Rashid A, Choh NA et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗
Eosinophilic/Inflammatory Cardiac Disease & Hypereosinophilic Syndromes
Metabolic and Redox Pathway Dysregulation in HIV-Associated Coronary Endothelial Dysfunction.
This prospective observational study examined whether coronary endothelial dysfunction in virally suppressed people with HIV (PWH) is linked to circulating proteomic signatures reflecting metabolic and redox pathway dysregulation. Integrating in vivo stress cardiovascular magnetic resonance with high-throughput serum proteomics in 45 virally suppressed PWH (and 29 age-matched controls), the study identified pathway-level proteomic alterations associated with endothelial dysfunction. These findings are significant because they provide mechanistic leads for persistent cardiovascular risk in treated HIV despite viral suppression.
Keole KS, Bukhari S, Minhas A et al. · American journal of physiology. Heart and circulatory physiology · (2026) · View on PubMed ↗
Loeffler Endocarditis: Multimodality Imaging of a Common Cardiac Phenotype in Distinct Hypereosinophilic Syndromes.
This case report described Loeffler endocarditis in a 43-year-old man with long-standing atopy and persistent eosinophilia due to a hypereosinophilic syndrome. Echocardiography and CMR demonstrated intracardiac (biventricular apical) thrombi with diffuse subendocardial late gadolinium enhancement consistent with fibrotic-stage disease, with rapid hematologic response to high-dose corticosteroids and anticoagulation. The report highlights multimodality imaging as a key tool for early recognition of Loeffler endocarditis in distinct hypereosinophilic syndromes.
Salar T, Feitell S, Parikh V et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗
Lymphatic endothelial cells actively shape immune responses in the lungs.
This narrative review summarized experimental evidence on how lung lymphatic endothelial cells actively shape immune responses. It highlights mechanisms such as PAR1-mediated permeabilization of lymphatic junctions that influence acute inflammation, adaptive immunity, and tissue remodeling. The review supports lymphatic endothelial biology as a potential therapeutic target for controlling pulmonary inflammatory and immune processes.
Rivers AK, Migues Ramirez C, Cleary SJ · Current opinion in immunology · (2026) · View on PubMed ↗ · Free PDF ↗
Hydroxychloroquine-associated cardiomyopathy with nondiagnostic noninvasive evaluation: diagnostic value of endomyocardial biopsy in a case-based review.
A 57-year-old woman with Sjögren’s disease treated with hydroxychloroquine (HCQ) 400 mg daily for ~21 years (~3,000 g cumulative dose) was evaluated for suspected HCQ-associated cardiomyopathy using comprehensive clinical assessment and endomyocardial biopsy after nondiagnostic noninvasive testing. The case-based review highlights that endomyocardial biopsy can provide diagnostic value when standard noninvasive evaluation fails to confirm HCQ cardiotoxicity. Clinically, this supports earlier consideration of invasive tissue diagnosis to guide management in patients with long-term HCQ exposure and evolving cardiac dysfunction.
Alkhatib A, Al-Kofahi M, Abumuhfouz M et al. · Rheumatology international · (2026) · View on PubMed ↗
Eosinophilic Cardiomyopathy in Eosinophilic Granulomatosis With Polyangiitis After Dupilumab Therapy.
This case report studied eosinophilic cardiomyopathy in a 64-year-old man with eosinophilic granulomatosis with polyangiitis (EGPA) that emerged after dupilumab therapy (IL-4Rα antagonist). Three months after starting dupilumab, he developed marked hypereosinophilia, elevated cardiac biomarkers, left ventricular dysfunction on echocardiography/CMR, and endomyocardial biopsy-confirmed eosinophilic myocarditis. The report is clinically significant because it links dupilumab-associated eosinophilia to severe eosinophilic myocardial involvement and supports prompt immunosuppression (high-dose corticosteroids plus cyclophosphamide) when biopsy confirms the diagnosis.
Agredano I, Michiels V, Argacha JF et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗
Association Between HIV Infection Duration and Left Ventricular Concentric Remodeling and Myocardial Fibrosis: A Cross-Sectional Study Using Cardiac MRI.
This prospective cross-sectional cardiac MRI study assessed the relationship between HIV infection duration and left ventricular (LV) concentric remodeling and myocardial fibrosis in 83 HIV-infected adults (short-duration <5 years vs long-duration ≥5 years) and 34 matched HIV-negative controls. It found that longer HIV infection duration was associated with worse LV structural remodeling (e.g., higher LV mass and mass-to-volume ratio) and increased myocardial fibrosis markers on MRI (using 1.5T SSFP cine and MOLLI T1 mapping). These findings suggest that cumulative HIV exposure contributes to progressive myocardial injury and that cardiac MRI metrics may help identify patients at higher risk of cardiovascular disease progression.
Deng C, Sun W, Gao T et al. · Journal of magnetic resonance imaging : JMRI · (2026) · View on PubMed ↗ · Free PDF ↗
Cardio-Oncology, Cancer-Related Cardiac Effects, and Cancer Imaging
AngioVac aspiration as a combined diagnostic and therapeutic strategy for an indeterminate right atrial mass in a patient with malignancy.
This case report studied catheter-directed AngioVac aspiration in a woman with primary mediastinal large B-cell lymphoma who had an indeterminate right atrial mass during evaluation for bacteremia. AngioVac aspiration achieved significant debulking and successful tissue retrieval, supporting a combined diagnostic–therapeutic approach when TTE/TEE/cardiac MRI could not reliably distinguish thrombus from malignant involvement and surgery was high risk. The report highlights AngioVac as a potentially safer alternative to surgical biopsy for right atrial masses in patients with active malignancy.
Abumuhfouz M, Sena A, Suleiman S et al. · Radiology case reports · (2026) · View on PubMed ↗
Sudden Death in Young Competitive Athletes Due to Arrhythmogenic Cardiomyopathy: A 4-Decade National Referral Center Experience.
This national referral-center registry study evaluated arrhythmogenic cardiomyopathy (ACM) as a cause of sudden cardiac death in young competitive athletes (≤40 years) in North-East Italy from 1985–2024, analyzing clinical and pathology data using the 1994 and 2010 diagnostic criteria. ACM accounted for 29% of athlete sudden deaths, with the study assessing prevalence and characteristics in the context of increased preparticipation screening awareness. These findings emphasize ACM’s substantial contribution to athletic sudden death and support continued refinement of screening and diagnostic criteria.
De Gaspari M, Pilichou K, Zorzi A et al. · Circulation. Arrhythmia and electrophysiology · (2026) · View on PubMed ↗
Current landscape of paediatric and young adult cardio-oncology care in Latin America.
This cross-sectional survey characterized the current landscape of pediatric and adolescent cardio-oncology care across Latin America, focusing on workforce training, infrastructure, diagnostic resources, follow-up strategies, and research capacity. The study found substantial variability and gaps in program implementation and resources across the region. These findings are important for guiding regional capacity-building to reduce long-term cardiovascular morbidity in childhood cancer survivors.
Stelmaszewski EV, Biancolini J, Gonzalez Ortiz A et al. · Cardiology in the young · (2026) · View on PubMed ↗
Osteosarcoma in a Young Patient: When the Tumor Reaches the Heart.
This case report studied cardiac metastasis from osteosarcoma in a 17-year-old boy with prior osteosarcoma who developed dyspnea and palpitations. Transthoracic echocardiography and cardiac magnetic resonance identified a mobile intracardiac mass attached to the tricuspid subvalvular apparatus with late gadolinium enhancement, and surgical resection with histopathology confirmed metastatic osteosarcoma. The findings emphasize that multimodality cardiac imaging can enable earlier recognition of rare intracardiac osteosarcoma metastases that are often diagnosed late.
Melem IC, Baratta SJ, Gutierrez G et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗
Generated automatically on June 17, 2026. Covers PubMed articles published June 10, 2026 – June 17, 2026. Summaries are AI-generated; always consult the original publication for clinical or research decisions.