What's New in Cardiac MRI? — June 18, 2026
AI-summarised digest of 67 PubMed articles on Cardiac MRI published in the last 7 days.
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What’s New in Cardiac MRI?
June 18, 2026 · 67 articles · 15 research themes · covering June 11, 2026 – June 18, 2026
Overview
Across this week’s PubMed set, a dominant theme is the push toward more quantitative, reproducible cardiovascular imaging—especially with cardiac MRI. Multiple studies and reviews focus on extracting richer tissue and structural information (e.g., LGE “granularity,” 3D LGE for atrial fibrosis, trabecular complexity) rather than relying on binary or qualitative readouts. Methodological work on uncertainty calibration, segmentation variability, multiplicity-aware strain comparisons, and acquisition strategies (including free-breathing cine and ultra-high-field 7T workflows) underscores that clinical translation depends on measurement reliability as much as on model performance.
A second major theme is the rapid expansion of AI/ML for scalable diagnosis and risk stratification, spanning automated image analysis (segmentation, strain, MR reconstruction) and decision support (HCM detection from ECG, explainable prediction of intramyocardial hemorrhage in STEMI, and AI-enabled MR/echo workflows for mitral regurgitation). Several papers emphasize generalizability and calibration—either by reducing adaptation data needs across sites or by building clinically usable outputs (e.g., bedside scores) and calibrated uncertainty.
Finally, the digest highlights how advanced imaging is increasingly used to connect molecular mechanisms and systemic disease to cardiovascular outcomes. Examples include PET/MR characterization of adrenal–cardiac remodeling in primary aldosteronism, proteomic links to HIV-related endothelial dysfunction, and multimodality phenotyping of myocarditis etiologies (viral vs immune-mediated) and constrictive pericarditis. Alongside these mechanistic and phenotyping efforts, interventional and therapeutic studies (e.g., ranolazine trial design for microvascular dysfunction post-STEMI, transcatheter pulmonary valve durability, cortisol-lowering in MACS, and FXN gene therapy in Friedreich ataxia) reflect a broader trend: imaging and biomarkers are being positioned not only to diagnose, but to guide earlier, more tailored management.
Cardiac MRI tissue characterization & scar quantification
Outcomes From the Multicenter ACCRU-LY-1804/CARiBOU TRIAL (Cytarabine, Acalabrutinib and Rituximab Integrated With Bortezomib-Based Outpatient Therapy) in 1st Line Mantle Cell Lymphoma.
This phase 2 multicenter ACCRU-LY-1804/CARiBOU trial studied a first-line, multitargeted regimen for previously untreated mantle cell lymphoma (MCL) in the academic/community ACCRU network, combining alternating VR-CAP and R-cytarabine with continuous acalabrutinib across six 21-day cycles. The primary endpoint was complete metabolic response (CMR) rate, with secondary endpoints including safety, feasibility of stem cell collection, proportion proceeding to autologous stem cell transplant (ASCT), and progression-free and overall survival. If effective and tolerable, this outpatient-integrated chemoimmunotherapy–BTK inhibitor strategy could improve durable responses in frontline MCL.
Smith SD, Sundaram S, Giri S et al. · American journal of hematology · (2026) · View on PubMed ↗
Giant Postischemic Left Ventricular Aneurysm Without Q Waves: Multimodality Imaging-Guided Surgery.
This JACC Case Reports report studied a 55-year-old woman with inferolateral myocardial infarction who developed a giant postischemic left ventricular aneurysm despite serial ECGs showing no pathological Q waves. Multimodality imaging demonstrated progressive left ventricular remodeling with aneurysmal evolution and mural thrombus formation, guiding successful surgical management. The case illustrates that nonanterior aneurysms can be missed on ECG alone and that multimodality imaging is critical for timely diagnosis and treatment.
Gaido L, Attisani M, Scalini F et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗
A simplified geometric CMR method for reproducible quantification of left ventricular thrombus volume : Left Ventricular thrombus: a standardized measurement method.
This post-hoc analysis from the COVERT-MI trial assessed a simplified geometric CMR method for reproducible quantification of left ventricular thrombus (LVT) volume in patients imaged 5 days after reperfusion for ST-segment elevation myocardial infarction. The key finding was that the simplified geometric approach was feasible and showed reproducibility suitable for standardized LVT volume assessment. Standardized, reproducible LVT quantification may improve how thrombus characteristics are linked to clinical evolution and embolic risk after MI.
Fuzeau A, Angoulvant D, Pucheux J et al. · The international journal of cardiovascular imaging · (2026) · View on PubMed ↗ · Free PDF ↗
High resolution, 3D isotropic late gadolinium enhanced imaging for the quantification of left atrial fibrosis and post-ablation scarring.
This prospective study evaluated a high-resolution, 3D isotropic late gadolinium enhancement (LGE) Dixon CMR sequence to quantify left atrial (LA) fibrosis and post-ablation scarring in 40 ablation-naïve atrial fibrillation patients (paroxysmal and persistent) and 20 healthy controls. The key finding was that the isotropic 3D LGE approach enabled more accurate depiction/quantification of LA fibrosis despite the thin atrial wall limitations of conventional LGE. This is significant because improved fibrosis quantification may better characterize atrial myopathy and refine risk stratification and treatment planning for AF.
Fenski M, Hickstein R, Krüger LD et al. · European heart journal. Imaging methods and practice · (2026) · View on PubMed ↗ · Free PDF ↗
Intramyocardial Dissecting Hematoma After Myocardial Infarction Diagnosed by Multimodality Imaging.
This JACC Case Reports report studied a 47-year-old man with myocardial infarction complicated by a rare intramyocardial dissecting hematoma that initially mimicked a left ventricular thrombus. The key finding was that multimodality imaging—especially cardiac MRI—demonstrated extensive anterior transmural infarction with a dissecting intramyocardial cavity consistent with intramyocardial dissection, after anticoagulation and clinical deterioration. Scientifically and clinically, it highlights the diagnostic value of cardiac MRI in distinguishing intramyocardial dissection from LV thrombus when anticoagulation fails and the patient develops cardiogenic shock or ventricular arrhythmias.
Borg BC, Josephs C, Ghincea C et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗
Clinical Importance of All the Characteristics of Late Gadolinium Enhancement from Acquisition to Expert and Artificial Intelligence Analysis: State-of-the-Art.
This state-of-the-art review examined how late gadolinium enhancement (LGE) characteristics on cardiovascular magnetic resonance—termed “LGE granularity” (location, extent, and pattern)—are acquired, processed, and interpreted by experts and artificial intelligence across cardiac diseases. It found that clinical and prognostic performance of LGE depends not only on presence/extent but also on standardized acquisition choices (contrast-media selection, post-processing) and consistent interpretation of detailed LGE features. This supports moving from binary LGE reporting toward comprehensive, reproducible LGE feature extraction to improve myocardial tissue characterization and risk stratification.
Florence J, Unger A, Gonçalves T et al. · Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · (2026) · View on PubMed ↗ · Free PDF ↗
Cardiac MRI functional imaging, strain, and remodeling
The correlation of cardiovascular magnetic resonance imaging findings with clinical diagnoses and its acute impact on management changes in a regional Australian hospital.
This retrospective single-center study assessed how cardiovascular magnetic resonance (CMR) findings changed diagnostic accuracy and acute management in 111 adult patients presenting with acute cardiovascular conditions at a regional Australian hospital in 2024. The key finding was that CMR significantly improved diagnostic agreement between pre- and post-CMR diagnoses and led to meaningful management changes after imaging. The study supports CMR as a practical “real-time” decision tool in acute care settings, not only a diagnostic reference standard.
Tan C, Thanabalasingam V, Hiskens MI et al. · Medicine · (2026) · View on PubMed ↗ · Free PDF ↗
Right Ventricular Remodeling in Repaired Tetralogy of Fallot: Imaging, Arrhythmia Risk, and Timing of Pulmonary Valve Replacement.
This narrative review studied right ventricular (RV) remodeling after repaired tetralogy of Fallot (rTOF) and linked imaging findings to arrhythmia risk and the timing of pulmonary valve replacement in patients surviving into adulthood. The key finding was that chronic pulmonary regurgitation, residual RV outflow tract obstruction, fibrosis, and electromechanical dyssynchrony drive dynamic RV dilatation and declining systolic/diastolic function, creating an arrhythmogenic substrate. Clinically, it supports using imaging-based characterization of RV remodeling to guide surveillance and optimize the timing of pulmonary valve replacement to reduce long-term complications.
Fatima H, Akram MB, Sher A et al. · Cardiology in review · (2026) · View on PubMed ↗
AI/ML for cardiac imaging analysis and automation
Filling the Gaps: Generating 4D Dense Cardiac Anatomy from Sparse CMR for Enhanced Tetralogy of Fallot Assessment.
This study developed and validated a deep learning pipeline to generate dense 4D cardiac anatomy from sparse cardiac MRI (CMR) acquisitions for improved assessment of repaired tetralogy of Fallot (rToF). By training on CT-derived isotropic 3D whole-heart segmentations and using simulated CMR-like sparse slices, the method aims to reconstruct comprehensive 3D anatomy despite inter-slice inconsistencies and motion artifacts. If validated clinically, this approach could enhance rToF evaluation by combining CMR accessibility with CT-like spatial detail.
Mauger C, Deng Y, Xu Y et al. · Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · (2026) · View on PubMed ↗ · Free PDF ↗
Advances in artificial intelligence for the evaluation of mitral regurgitation.
This narrative review summarized current and emerging artificial intelligence approaches for the evaluation of mitral regurgitation (MR) across the diagnostic pathway, including upstream screening and advanced multimodality imaging. The key finding was that AI-enabled tools such as digital stethoscopes and deep learning ECG models are increasingly used for scalable enrichment and early detection, but often are not yet standalone definitive diagnostics. Improved AI integration could reduce interobserver variability and streamline MR workup, accelerating clinical decision-making.
Sanchez AA, Sadeghpour A, Asch FM · Current opinion in cardiology · (2026) · View on PubMed ↗
Quantification of mitral regurgitation: from traditional methods to artificial intelligence.
This review article examined how mitral regurgitation (MR) quantification has evolved from traditional echocardiographic geometric, single-frame methods to artificial intelligence approaches that analyze regurgitant flow throughout systole and account for eccentric/multiple/non-holosystolic jets. It reports that AI-based MR quantification can provide automated grading with favorable agreement with cardiac magnetic resonance (CMR) measurements. Improved AI-driven MR quantification is significant because it can reduce geometric assumption errors and improve accuracy for complex MR phenotypes on echocardiography.
Cho K, Su J, Bonnefous O et al. · Cardiovascular ultrasound · (2026) · View on PubMed ↗ · Free PDF ↗
Parameter-efficient adaptation of foundational models for automated myocardial strain analysis.
This study investigated parameter-efficient adaptation of foundational deep learning models for automated myocardial strain analysis in cross-domain cardiac imaging, focusing on segmentation and motion tracking across scanners/institutions. It developed CardiacSAM by fine-tuning the Segment Anything Model (SAM) with Low-Rank Adaptation (LoRA) for cardiac structure segmentation and pairing it with uniGradICON for myocardial motion estimation to enable robust global strain computation with minimal adaptation data. This is significant because it reduces the data burden for deploying automated strain models across new sites while improving generalizability beyond single-dataset training.
Bernardo A, Mato G, Calandrelli M et al. · Biomedical physics & engineering express · (2026) · View on PubMed ↗ · Free PDF ↗
AI/ML for cardiovascular risk prediction and decision support
Artificial Intelligence for the Detection of Hypertrophic Cardiomyopathy From Standard Electrocardiogram.
This study evaluated an artificial intelligence algorithm (Viz HCM; Viz.ai) for detecting hypertrophic cardiomyopathy (HCM) from standard 12-lead ECGs in 150 patients with cMRI-confirmed HCM and 83 control patients without cardiomyopathy. The AI model labeled ECGs as HCM and the study assessed performance and predictors of correct classification against physician-reviewed medical records and cMRI ground truth. Earlier, scalable ECG-based detection of HCM could reduce diagnostic delay and enable earlier risk stratification and treatment planning.
Park J, Kermanshahchi J, Love CJ et al. · JACC. Advances · (2026) · View on PubMed ↗ · Free PDF ↗
A Narrative Review of Risk Assessment Approaches for Implantable Defibrillator Therapy to Prevent Sudden Cardiac Death in Acute Myocardial Infarction.
This narrative review evaluated risk assessment strategies for implantable defibrillator (ICD) therapy to prevent sudden cardiac death in acute myocardial infarction, contrasting traditional left ventricular ejection fraction (LVEF)-based models with emerging multimodal approaches. The key message is that LVEF alone has limited sensitivity/specificity and that newer strategies (including advanced cardiac MRI–based modalities) aim to better stratify risk. More accurate risk models could improve ICD selection after STEMI and reduce both missed high-risk patients and unnecessary device implantation.
Kakavand N, Shojaei Y, Sadri M et al. · Cardiology research and practice · (2026) · View on PubMed ↗ · Free PDF ↗
Predicting Intramyocardial Hemorrhage Before Reperfusion in STEMI Patients With Intrinsically Explainable Artificial Intelligence.
This JACC Advances study evaluated an intrinsically explainable artificial intelligence model to predict intramyocardial hemorrhage (IMH) before reperfusion in 288 ST-segment elevation myocardial infarction (STEMI) patients from the MIRON-PREDICT clinical study (NCT06423625). The key finding was that the explainable AI approach could identify patients at risk for IMH prior to reperfusion and was translated into a practical bedside score using pre-reperfusion electrocardiographic, angiographic, and clinical variables. Clinically, this enables earlier risk stratification and potentially more tailored management for STEMI patients likely to develop IMH.
Youssef K, Vora KP, Gupta R et al. · JACC. Advances · (2026) · View on PubMed ↗ · Free PDF ↗
Cardiac CT and PET for myocardial assessment
Right Ventricular Strain Analysis with PET-derived Feature Tracking: Direct Comparison with Magnetic Resonance using Hybrid PET/MR.
This retrospective hybrid PET/MR study compared right ventricular (RV) strain quantification using a newly developed PET feature tracking technique against magnetic resonance (MR) strain as the reference standard in 123 patients undergoing rest 13N ammonia PETMR. The key finding was that PET-derived RV strain analysis was feasible and could be directly compared with MR-derived strain metrics using semi-automatic MATLAB-based feature tracking. If reproducible, PET-based RV strain could expand functional assessment in settings where PET is already performed.
Katahira M, Fukushima K, Ikeda A et al. · Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · (2026) · View on PubMed ↗
The Feasibility of Low Contrast Dose Dual-energy CT for Quantifying Myocardial Focal Scar via Extracellular Volume Fraction.
This prospective study assessed whether low-contrast-dose dual-energy CT (DECT) using extracellular volume fraction (ECV) can quantify myocardial focal scar (MFS) compared with cardiac magnetic resonance (CMR) ECV and CMR late gadolinium enhancement (LGE) in 33 patients with old myocardial infarction. It found that DECT-LIE-derived ECV (DECT-LIE-ECV) and CMR-ECV could be measured segmentally and that quantitative agreement/performance was evaluated against CMR-LGE-defined MFS and remote myocardium on the same slice. The significance is that low-contrast DECT may provide a radiation/contrast-sparing alternative for quantitative scar assessment when CMR is unavailable or impractical.
Chen F, Jia T, Luo L et al. · The British journal of radiology · (2026) · View on PubMed ↗
Cardiac hemodynamics, flow quantification, and valvular/regurgitation measurement
Agreement between ventricular stroke volumes and great vessel flow using cine and phase-contrast MRI in healthy subjects.
This study assessed agreement between ventricular stroke volumes derived from cine CMR (LV-SV and RV-SV) and great-vessel forward flows measured by phase-contrast CMR (ascending aorta and pulmonary artery) in 15 healthy volunteers. Bland–Altman and intraclass correlation analyses showed systematic biases (notably negative additive bias for RV-PA, RV-Ao, and RV-LV pairs) and quantified the level of concordance across parameter pairs. Establishing how well these CMR-derived measures agree is important for accurate quantification of valvular regurgitation and related hemodynamic calculations.
Kawaguchi A, Kawaguchi W, Hayashi M et al. · Radiological physics and technology · (2026) · View on PubMed ↗ · Free PDF ↗
Aortic Stenosis Progression: Lessons from Multimodality Imaging.
This review studied the progression of calcific aortic stenosis in aging patients and summarized how multimodality imaging characterizes disease biology and severity. It found that echocardiography, cardiac MRI, cardiac CT, and nuclear imaging can quantify valve calcification and metabolic activity, providing “imaging checkpoints” that may be used to track progression and serve as targets for trials aimed at halting progression. Clinically, this supports using multiple imaging modalities to better stage disease and to evaluate whether emerging metabolic or signaling-pathway interventions slow aortic stenosis before severe outcomes occur.
Jain R, Padang R, Postalian A et al. · Mayo Clinic proceedings · (2026) · View on PubMed ↗
Cardiovascular magnetic resonance reclassification of aortic regurgitation after transcatheter aortic valve implantation: A COMPARE-TAVI 1 substudy.
This COMPARE-TAVI 1 substudy compared transthoracic echocardiography (TTE) versus cardiovascular magnetic resonance (CMR) for assessing aortic regurgitation after transcatheter aortic valve implantation (TAVI) in randomized patients receiving Sapien 3/Sapien 3 Ultra or Myval/Myval Octacor valves. The key finding was that CMR provides direct quantification of regurgitant flow and can reclassify post-TAVI aortic regurgitation relative to semiquantitative, operator-dependent TTE using standardized VARC-3 criteria. Scientifically and clinically, this suggests CMR may improve risk stratification and trial endpoint consistency for post-TAVI regurgitation assessment.
Pedersen AAU, Pedersen ALD, Mogensen NSB et al. · Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · (2026) · View on PubMed ↗ · Free PDF ↗
Myocarditis and pericarditis (etiology, phenotyping, and outcomes)
Clinical and Cardiac Magnetic Resonance Phenotype of Probable Viral versus Probable Immune-mediated Acute Myocarditis.
This study compared the clinical presentation, cardiac magnetic resonance (CMR) phenotype, and prognosis of clinically defined probable viral myocarditis (pVM) versus probable immune-mediated myocarditis (pIM) in patients referred for CMR at two tertiary centers. pVM was defined as myocarditis within 14 days of a documented infection, while pIM was defined as acute myocarditis in patients with known systemic autoimmune disease, and the study assessed whether these groups differed in CMR findings and outcomes. The work supports using CMR phenotyping to help stratify myocarditis etiology when endomyocardial biopsy is not routinely performed.
Bernhard B, Fabian E, Stoyanov K et al. · European journal of heart failure · (2026) · View on PubMed ↗
Loeffler Endocarditis: Multimodality Imaging of a Common Cardiac Phenotype in Distinct Hypereosinophilic Syndromes.
This JACC Case Reports article described Loeffler endocarditis in distinct hypereosinophilic syndromes, focusing on multimodality imaging findings in a 43-year-old man with atopy and persistent eosinophilia. Echocardiography showed biventricular apical thrombi and CMR confirmed ventricular thrombi with diffuse subendocardial late gadolinium enhancement consistent with fibrotic-stage disease, with rapid hematologic response to high-dose corticosteroids and anticoagulation. The case highlights how early multimodality imaging can improve recognition of a treatable cardiac phenotype in hypereosinophilic disorders.
Salar T, Feitell S, Parikh V et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗
Hemorrhagic Eosinophilic Pericardial Effusion Associated With Probable Sparganosis.
This case report described a 25-year-old man who developed hemorrhagic eosinophilic pericardial effusion after ingesting undercooked frog meat, with diagnostic workup supporting probable sparganosis (Spirometra infection). The key finding was that extensive testing—including cultures, cytology, imaging (including CMR and PET/CT), and next-generation sequencing—failed to identify an alternative cause, while eosinophilia, eosinophils in pericardial fluid, and markedly elevated IgE supported helminthic etiology. The clinical significance is that sparganosis should be considered in hemorrhagic eosinophilic pericardial effusion after relevant dietary exposure, even when routine diagnostics are inconclusive.
Zhu Y, Wang D, Wu Y et al. · International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · (2026) · View on PubMed ↗ · Free PDF ↗
Myocardial tuberculosis: a diagnostic challenge illustrated by two cases and review of contemporary management.
The study reported two clinical cases of myocardial tuberculosis (one disseminated and one isolated) and reviewed contemporary management in patients with extrapulmonary TB involving the myocardium. Both patients received first-line anti-tuberculosis therapy (with one also receiving corticosteroids and therapeutic anticoagulation), and both had favorable clinical and radiological outcomes. The report highlights that myocardial TB is rare but should be considered in the differential diagnosis of cardiac disease to avoid misdiagnosis and to enable timely, appropriate treatment.
Tremouilhac EM, Richaud C, Tresorier R et al. · The international journal of cardiovascular imaging · (2026) · View on PubMed ↗ · Free PDF ↗
Left ventricular strain and hemodynamic forces from cine CMR for detecting constrictive physiology in pericarditis.
This retrospective study evaluated whether cine CMR–derived left ventricular strain metrics (global longitudinal strain and global circumferential strain) and hemodynamic force analysis can noninvasively distinguish constrictive physiology from non-constrictive physiology in patients with CMR-confirmed pericarditis. Using routine 1.5T cine images from 2008–2024, the key finding was that cine-based strain and hemodynamic forces improved diagnostic discrimination of constrictive physiology compared with qualitative CMR assessment alone. Clinically, this supports a more quantitative CMR workflow to identify constrictive pericarditis earlier and potentially reduce delays in management.
Vollbrecht TM, Proff A, Juraschitz S et al. · Insights into imaging · (2026) · View on PubMed ↗ · Free PDF ↗
Constrictive Pericarditis and Bilateral Pleural Effusions Unmasked in an HLA-B27 Positive Patient.
This JACC Case Reports article described a 40-year-old HLA-B27–positive patient in whom constrictive pericarditis and bilateral pleural effusions were unmasked after an initial presentation consistent with acute pericarditis. The key finding was that the patient progressed to constrictive physiology and ultimately required radical pericardiectomy after failure of medical therapy, with symptom resolution afterward. The case is significant because it proposes a potential association between HLA-B27 positivity and constrictive pericarditis, which may influence etiologic evaluation in similar patients.
Villalonga M, Al-Dalakta A, El Roumi J et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗
Cardiac amyloidosis and other infiltrative diseases
Multimodality imaging characterization of Perugini scintigraphic grades in transthyretin amyloid cardiomyopathy: a single-center experience.
This single-center retrospective study evaluated multimodality imaging characteristics and diagnostic yield across Perugini scintigraphic grades in transthyretin amyloid cardiomyopathy (ATTR-CM) using technetium-99m pyrophosphate (99mTc-PYP) scintigraphy. By comparing clinical and imaging features among Perugini grades 2 and 3 (both considered diagnostic), the authors aimed to determine whether these grades reflect distinct phenotypes. The findings could refine noninvasive diagnostic interpretation of ATTR-CM and improve prognostic or phenotypic risk stratification based on scintigraphy grade.
Bucius P, Zarambaite E, Lusaite K et al. · Journal of cardiovascular imaging · (2026) · View on PubMed ↗
Design and Rationale of the REVEAL PET Study: A Study of 124I-evuzamitide to Diagnose Cardiac Amyloidosis.
This article presented the design and rationale for the multicenter phase 3 REVEAL PET study evaluating 124I-evuzamitide PET/CT for diagnosing cardiac amyloidosis in adults with suspected disease across 18 U.S. centers. The key scientific premise is that 124I-evuzamitide is a fibril-targeting radiotracer binding hypersulfated heparan sulfate glycans present across multiple amyloid subtypes. A validated diagnostic performance for this tracer could improve noninvasive detection and staging of cardiac amyloidosis.
Dorbala S, Maurer MS, Cuddy SAM et al. · Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · (2026) · View on PubMed ↗
Cardiomyopathies (genetic/phenotypic risk, HCM/ApHCM/Fabry/ACM)
Occult Idiopathic Ventricular Fibrillation After Preoperative Cardiovascular Evaluation.
This case report evaluated a 50-year-old man who experienced occult idiopathic ventricular fibrillation shortly after preoperative cardiovascular clearance for elective surgery. Despite extensive workup—including coronary angiography, cardiac magnetic resonance, electrophysiological study, and genetic testing—no structural heart disease or inherited arrhythmia syndrome was identified, and a dual-chamber implantable cardioverter-defibrillator was implanted for secondary prevention. The report emphasizes that idiopathic ventricular fibrillation can present abruptly even after “normal” preoperative evaluation and supports consideration of ICD therapy when no reversible cause is found.
Ganthan RR, Isber R, Elcicek A et al. · JACC. Case reports · (2026) · View on PubMed ↗
Multimodal phenotypic clustering predicts cardiac outcomes in Fabry disease.
This study developed and tested a multimodal phenotypic clustering framework to predict cardiac outcomes in Fabry disease by integrating sex, genetics, clinical assessments, ECG, imaging, and biomarkers across 98 participants (525 “visit years”). The key finding was that the integrated clustering approach could stratify patients by risk of adverse cardiovascular outcomes more effectively than relying on any single modality. This supports a comprehensive, data-driven cardiac monitoring strategy in Fabry disease to better anticipate progression and guide follow-up intensity.
Shemesh E, Feigin P, Tan CY et al. · Orphanet journal of rare diseases · (2026) · View on PubMed ↗
Phenotype, genotype and prognosis of Apical Hypertrophic Cardiomyopathies: A French multicentric cohort.
This French multicenter cohort study characterized phenotype, genotype, and prognosis in 201 patients with apical hypertrophic cardiomyopathy (ApHCM) confirmed by echocardiography and cardiac magnetic resonance, with genetic testing performed and follow-up for outcomes. Compared with 419 patients with non-apical HCM (excluding patients with Fabry disease and amyloidosis), the study assessed how apical distribution relates to genetic patterns and clinical prognosis. The results help clarify whether ApHCM represents a distinct clinical-genetic entity with different risk compared with non-apical hypertrophic cardiomyopathy.
Martel H, Lucas C, Benjelloun H et al. · European heart journal. Cardiovascular Imaging · (2026) · View on PubMed ↗
Left Atrial Reservoir Strain for Predicting Progression to End-Stage in Hypertrophic Cardiomyopathy.
This cohort study analyzed 925 patients with hypertrophic cardiomyopathy (HCM) followed with echocardiography to identify predictors of progression to end-stage HCM (LVEF <50% without reversible causes), with a CMR subcohort of 491 patients. The key finding was that left atrial reservoir strain measured at baseline was associated with subsequent progression to end-stage disease. Using left atrial reservoir strain for risk prediction could improve prognostication and help identify patients who may benefit from closer monitoring or earlier intervention.
Kwak S, Jeong MH, Park CS et al. · European heart journal. Cardiovascular Imaging · (2026) · View on PubMed ↗
Apical Hypertrophic Cardiomyopathy Misdiagnosed as Hypertensive Heart Disease Due to Anchoring Bias in an African Man: A Case Report.
This case report described an African man with longstanding hypertension who was initially misdiagnosed with hypertensive heart disease but ultimately had apical hypertrophic cardiomyopathy (ApHCM), emphasizing anchoring bias as a contributor to the diagnostic error. The key finding was that the patient’s true diagnosis was ApHCM rather than hypertensive heart disease, reflecting how cognitive bias can override contradictory clinical evidence in settings where CMR is unavailable. Scientifically and clinically, it underscores the need for careful differential diagnosis and access to cardiac magnetic resonance imaging to correctly identify ApHCM in hypertensive patients.
Okema JN, Chukwuocha C, Danvictor E et al. · International medical case reports journal · (2026) · View on PubMed ↗
Apical Hypertrophic Cardiomyopathy and Elite-Level Sports: A 12-Year Follow-Up Case.
This 12-year follow-up case report followed an asymptomatic elite athlete diagnosed with apical hypertrophic cardiomyopathy (aHCM) from ages 17 to 31 years. The key finding was that sustained elite-level sports participation did not lead to adverse morphological changes or progression of apical fibrosis, even after retirement from professional sports. Clinically, it suggests that aHCM may have a different sports-related risk profile than other hypertrophic cardiomyopathy phenotypes, informing individualized counseling.
Thio Q, van Hattum J, Nijland F et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗
Prognostic Value of MRI-Based Left Ventricular Trabecular Complexity for Sudden Cardiac Death in Hypertrophic Cardiomyopathy.
This prospective study validated MRI-based left ventricular trabecular complexity using fractal dimension (FD) for sudden cardiac death (SCD) prediction in 835 hypertrophic cardiomyopathy (HCM) patients and examined relationships with sarcomere variants. The key finding was that LV trabecular complexity measured on 3T SSFP cine imaging was prognostically informative for SCD risk and associated with underlying sarcomere genetic variation. Scientifically, it suggests FD-derived myocardial microstructural complexity could improve early risk stratification for preventive interventions in HCM.
Zhang J, Yu M, Pu L et al. · Journal of magnetic resonance imaging : JMRI · (2026) · 1 citations · View on PubMed ↗
Cardiovascular effects of systemic diseases and therapies
AAVrh.10hFXN Gene Therapy for the Cardiomyopathy of Friedreich Ataxia: A Nonrandomized Clinical Trial.
This nonrandomized clinical trial studied AAVrh.10hFXN gene therapy (AAVrh.10 serotype vector delivering the normal human FXN coding sequence) in adults with Friedreich ataxia (FA) cardiomyopathy caused by pathogenic variants in the frataxin (FXN) gene. The study reports safety and preliminary efficacy outcomes following systemic administration of AAVrh.10hFXN, building on preclinical evidence that the same approach reverses cardiomyopathy in FXN-deficient mice. If confirmed in larger studies, this FXN gene-replacement strategy could provide a disease-modifying treatment for FA-related cardiomyopathy, a major cause of death in FA.
Crystal RG, Weinsaft JW, Kaminsky SM et al. · JAMA cardiology · (2026) · View on PubMed ↗
Rapid Onset of Iron Overload Cardiomyopathy in Cirrhosis.
This JACC Case Reports article describes two patients with cirrhosis who developed rapid iron overload cardiomyopathy (IOC) without hereditary hemochromatosis or transfusion-dependent anemia. Both patients presented with new or worsening severe cardiomyopathy with markedly reduced left ventricular ejection fraction, demonstrating that IOC can emerge quickly in cirrhosis. Clinically, the cases suggest that iron overload should be considered in cirrhotic patients with unexplained or rapidly progressive heart failure.
Nouraee CM, Swain WH, Harmon DM et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗
Metabolic and Redox Pathway Dysregulation in HIV-Associated Coronary Endothelial Dysfunction.
This prospective observational study investigated whether coronary endothelial dysfunction in virally suppressed people with HIV (PWH) is associated with circulating proteomic signatures of metabolic and redox pathway dysregulation, using stress cardiovascular magnetic resonance (CMR) and high-throughput serum proteomics in 45 virally suppressed PWH and 29 age-matched controls. The key finding was that endothelial dysfunction correlated with specific serum proteomic patterns consistent with metabolic and redox pathway dysregulation. These mechanistic biomarkers may help explain residual cardiovascular risk in treated HIV and could guide targeted prevention strategies.
Keole KS, Bukhari S, Minhas A et al. · American journal of physiology. Heart and circulatory physiology · (2026) · View on PubMed ↗
Association of Subclinical Cardiac Remodeling With Incident Cancer in the MESA Cohort.
This study examined whether CMR-derived measures of subclinical cardiac remodeling are associated with incident cancer in the Multi-Ethnic Study of Atherosclerosis (MESA) cohort using multivariable Cox proportional hazards models. The key finding was that specific CMR remodeling metrics were linked to higher or lower risk of developing cancer over follow-up. If validated, CMR-based detection of early cardiac remodeling could provide a novel cardiovascular–oncology risk marker.
Cai X, White Q, Juarez J et al. · Journal of the American Heart Association · (2026) · View on PubMed ↗ · Free PDF ↗
Lymphatic endothelial cells actively shape immune responses in the lungs.
This review synthesized experimental evidence on how lymphatic endothelial cells actively shape immune responses in the lungs, focusing on organ-specific lymphatic endothelial functions. The key finding was that pulmonary lymphatic endothelial cells regulate inflammation and adaptive immunity through mechanisms such as PAR1-mediated permeabilization of lymphatic junctions and other junctional/immune-modulatory pathways. Understanding these mechanisms could inform therapeutic strategies to control lung inflammation and remodeling.
Rivers AK, Migues Ramirez C, Cleary SJ · Current opinion in immunology · (2026) · View on PubMed ↗ · Free PDF ↗
Hydroxychloroquine-associated cardiomyopathy with nondiagnostic noninvasive evaluation: diagnostic value of endomyocardial biopsy in a case-based review.
This case-based review described diagnostic challenges in hydroxychloroquine (HCQ)-associated cardiomyopathy when noninvasive testing is nondiagnostic, focusing on the diagnostic value of endomyocardial biopsy. In a 57-year-old woman with Sjögren’s disease treated with HCQ 400 mg daily for ~21 years (cumulative dose ~3,000 g), endomyocardial biopsy provided diagnostic clarification after symptoms such as syncope and dyspnea emerged. The clinical significance is that biopsy may be crucial for confirming HCQ cardiotoxicity when standard noninvasive evaluations fail to establish a diagnosis.
Alkhatib A, Al-Kofahi M, Abumuhfouz M et al. · Rheumatology international · (2026) · View on PubMed ↗
Primary Aldosteronism: CXCR4- and FAP-Targeted PET/MR for Adrenal-Cardiac Axis.
This Circulation: Cardiovascular Imaging study used CXCR4-targeted 68Ga-Pentixafor PET/MR and FAP-targeted 68Ga-FAPI-04 PET combined with cardiac MRI to characterize the adrenal–cardiac axis in 82 participants with primary aldosteronism (40 total: 21 aldosterone-producing adenoma and 19 idiopathic hyperaldosteronism) versus essential hypertension (42). The key finding was that in vivo imaging of CXCR4-associated activity and fibroblast activation protein (FAP)–associated fibroblast activation could link adrenocortical activity to myocardial remodeling processes in primary aldosteronism. This is significant because it provides mechanistic, molecular imaging evidence for cardiovascular risk in PA beyond hemodynamic load and may guide targeted risk assessment or therapy.
Ding J, Wang K, Song J et al. · Circulation. Cardiovascular imaging · (2026) · View on PubMed ↗
Cardiovascular effects of metyrapone treatment in patients with mild autonomous cortisol secretion: a secondary analysis.
This secondary analysis studied cardiovascular effects of cortisol-lowering therapy with metyrapone in 15 patients with mild autonomous cortisol secretion (MACS) from a prospective, open-label, single-center study at the Medical University of Vienna. After 12 weeks of evening metyrapone dosing (500 mg at 6 p.m. and 250 mg at 10 p.m.), the study evaluated changes in blood pressure regulation, cardiac fat depots, heart function and morphology, and other cardiovascular risk factors. The significance is that it tests whether pharmacologic suppression of cortisol can improve cardiovascular phenotype in MACS, informing potential medical management strategies.
Niziolek H, Just I, Baumgartner C et al. · The Journal of clinical endocrinology and metabolism · (2026) · View on PubMed ↗ · Free PDF ↗
Cardiovascular imaging in oncology and immune-related toxicity
Pectus Excavatum-Induced Preload Insufficiency Presenting as Long-Standing Sinus Tachycardia.
This case report studied a 65-year-old woman with long-standing sinus tachycardia refractory to high-dose beta-blockade, ultimately attributed to severe pectus excavatum causing cardiac compression. Right heart catheterization showed markedly low filling pressures (mean right atrial pressure 1 mm Hg) with preserved cardiac output, and cardiovascular magnetic resonance demonstrated severe pectus excavatum (Haller index 8.1) with anterior cardiac compression. The findings highlight preload insufficiency from chest wall deformity as a reversible cause of persistent sinus tachycardia and support multimodal hemodynamic imaging for diagnosis.
Alkhatib R, Zghyer F, Hatab T et al. · JACC. Case reports · (2026) · View on PubMed ↗
Chest Pain With Immune Checkpoint Inhibitor Therapy: Harnessing the Power of Multimodality Imaging.
This case report examined a 53-year-old woman with metastatic lung adenocarcinoma receiving the immune checkpoint inhibitor pembrolizumab who presented with worsening pleuritic chest pain. Serial computed tomography showed progressive pericardial thickening with elevated inflammatory markers and transaminitis, consistent with a cardiovascular immune-related adverse event (pericarditis) rather than infection or pulmonary embolism. The report underscores the clinical value of multimodality imaging to recognize and diagnose ICI-associated pericarditis early.
Roy R, Liu L, Li H et al. · JACC. Case reports · (2026) · View on PubMed ↗
Fulminant Eosinophilic Myocarditis After Sequential Biologic Therapy in Ulcerative Colitis.
This case report studied a 35-year-old man with ulcerative colitis who developed fulminant eosinophilic myocarditis after sequential biologic therapy, most recently vedolizumab, with corticosteroid withdrawal. He rapidly progressed to cardiogenic shock with severe biventricular dysfunction (left ventricular ejection fraction 10%) and hypereosinophilia (2,154/µL), with cardiac magnetic resonance suggesting diffuse myocardial involvement and endomyocardial biopsy confirming eosinophilic myocarditis. The case highlights a potentially life-threatening immune-mediated myocarditis phenotype linked to biologic therapy transitions and the need for urgent biopsy/imaging-guided management.
Lee J, Kim D, Hong D et al. · JACC. Case reports · (2026) · View on PubMed ↗
Benralizumab as a steroid-sparing rescue therapy in ANCA-negative eosinophilic granulomatosis with polyangiitis: real-world experience from three cases and review of the literature.
This real-world case series and literature review evaluated benralizumab, an anti–IL-5 receptor monoclonal antibody that rapidly depletes eosinophils, as steroid-sparing rescue therapy in three patients with ANCA-negative eosinophilic granulomatosis with polyangiitis (EGPA). Across the cases, benralizumab was used for severe disease that was steroid-dependent or refractory despite conventional immunosuppression, with attention to clinical manifestations, eosinophil kinetics, and glucocorticoid reduction. These observations support benralizumab as a potential targeted option for type 2–driven ANCA-negative EGPA when steroid minimization is needed.
Sebastian A, Kosałka-Węgiel J, Puchala M et al. · Rheumatology international · (2026) · View on PubMed ↗ · Free PDF ↗
Sudden Death in Young Competitive Athletes Due to Arrhythmogenic Cardiomyopathy: A 4-Decade National Referral Center Experience.
This national referral-center registry study examined the prevalence and characteristics of arrhythmogenic cardiomyopathy (ACM) among young competitive athletes (≤40 years) who died suddenly, using data from a juvenile sudden death registry in North-East Italy spanning 1985–2024 and applying the 1994 and 2010 diagnostic criteria. ACM accounted for 29% of sudden cardiac deaths in athletes, and the analysis characterized cases according to clinical and pathology guidelines. The findings emphasize that ACM remains a substantial contributor to athlete sudden death and support the value of improved preparticipation screening and diagnostic awareness.
De Gaspari M, Pilichou K, Zorzi A et al. · Circulation. Arrhythmia and electrophysiology · (2026) · View on PubMed ↗ · Free PDF ↗
Myopericarditis After Combined Idarubicin and Quizartinib in FLT3-ITD-Positive AML.
This JACC Case Reports report describes a 64-year-old man with FLT3-ITD–positive acute myelogenous leukemia who developed myopericarditis after combined idarubicin and quizartinib (with cytarabine) during induction therapy. Cardiac injury was suggested by fever, hypotension, troponin I elevation, and diffuse ST-segment elevation, and cardiac magnetic resonance imaging showed late gadolinium enhancement consistent with myopericarditis. The case highlights a clinically important potential interaction between anthracycline cardiotoxic exposure and FLT3 inhibition with quizartinib, informing monitoring and risk mitigation in AML patients.
Spahr ZR, Vasquez MA, Tangella A et al. · JACC. Case reports · (2026) · 1 citations · View on PubMed ↗ · Free PDF ↗
Fluoropyrimidine Cardiotoxicity With Overlapping Vasospastic and Pericardial Features: A Diagnostic Challenge.
This JACC Case Reports article presents a diagnostic challenge in a 57-year-old man with HER2-positive gastric cancer receiving FOLFOX-6M plus trastuzumab who developed fluoropyrimidine (5-fluorouracil) cardiotoxicity with overlapping vasospastic and pericardial features. During 5-FU infusion he developed severe chest pain with ECG changes and marked QTc prolongation despite negative biomarkers, followed later by new concave ST-segment elevation, while echocardiography and coronary CT angiography were initially normal. The report underscores that fluoropyrimidine cardiotoxicity can present with mixed coronary spasm and inflammatory pericardial patterns, complicating diagnosis and management.
Viñas-Mendieta AE, Valencia-Hernandez HA, Ruiz-Mori E et al. · JACC. Case reports · (2026) · 1 citations · View on PubMed ↗ · Free PDF ↗
Osteosarcoma in a Young Patient: When the Tumor Reaches the Heart.
This case report described a 17-year-old boy with prior osteosarcoma who developed a cardiac metastasis presenting as a mobile intracardiac mass near the tricuspid subvalvular apparatus. The key finding was that echocardiography and cardiac magnetic resonance (with heterogeneous signal and late gadolinium enhancement) suggested malignancy, and surgical resection with histopathology confirmed metastatic osteosarcoma. The report is clinically important because it emphasizes that cardiac metastases from osteosarcoma, though rare, should be considered when intracardiac masses are detected in young patients with cancer history.
Melem IC, Baratta SJ, Gutierrez G et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗
Eosinophilic Cardiomyopathy in Eosinophilic Granulomatosis With Polyangiitis After Dupilumab Therapy.
This case report described a 64-year-old man who developed eosinophilic cardiomyopathy after dupilumab therapy, with progression to eosinophilic granulomatosis with polyangiitis–like disease features. The key finding was that endomyocardial biopsy confirmed eosinophilic myocarditis, and treatment with high-dose corticosteroids plus cyclophosphamide led to rapid clinical improvement. Scientifically and clinically, it highlights a rare but severe cardiac complication temporally associated with dupilumab-induced eosinophilia, supporting prompt cardiac evaluation and aggressive therapy when myocarditis is suspected.
Agredano I, Michiels V, Argacha JF et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗
Cardiac imaging in special populations (pediatrics, COVID-19, athletes, HIV)
Long-term CMR Findings in Pediatric COVID-19 Related Myocarditis.
This retrospective study evaluated long-term cardiac magnetic resonance (CMR) findings in 21 pediatric patients (mean age 13.1 years) with suspected COVID-19–related myocarditis, imaged at <30 days, 30–364 days, and ≥365 days using the 2009 Lake Louise criteria. While acute abnormalities were common, the study focused on whether myocarditis-related CMR abnormalities persisted across early, mid, and long-term intervals. These data help define the expected durability of CMR-detected myocardial injury after COVID-19–associated myocarditis/MIS-C in children and can inform follow-up strategies.
Vasquez Choy AL, Adebo DA, Patel MD et al. · Pediatric cardiology · (2026) · View on PubMed ↗
Association Between HIV Infection Duration and Left Ventricular Concentric Remodeling and Myocardial Fibrosis: A Cross-Sectional Study Using Cardiac MRI.
This prospective cross-sectional cardiac MRI study assessed whether HIV infection duration is associated with left ventricular concentric remodeling and myocardial fibrosis using 1.5T SSFP cine and MOLLI sequences in 83 HIV-infected participants (short-duration <5 years vs long-duration ≥5 years) and 34 matched HIV-negative controls. The key finding was that longer HIV infection duration correlated with worse MRI markers of concentric remodeling and increased myocardial fibrosis burden. Clinically, this supports using cardiac MRI tissue and geometry metrics to detect chronic HIV-related cardiac injury and to identify patients who may benefit from earlier cardiovascular risk management.
Deng C, Sun W, Gao T et al. · Journal of magnetic resonance imaging : JMRI · (2026) · View on PubMed ↗ · Free PDF ↗
Interventional cardiology and device therapy outcomes
Prospective Midterm Outcomes of the PULSTA Self-Expandable Transcatheter Pulmonary Valve: The PULSTA CE Approval Study.
This prospective, multinational, nonrandomized PULSTA CE approval study evaluated the midterm safety, hemodynamic performance, and durability of the PULSTA self-expandable transcatheter pulmonary valve (PULSTA Carpentier Edwards) in 58 patients across 11 centers. The study’s key focus was whether the self-expanding valve could reduce the need for repeated surgical pulmonary valve replacements by maintaining function over midterm follow-up. These results are clinically important for selecting transcatheter pulmonary valve therapy in patients with congenital or surgically repaired right ventricular outflow tract dysfunction.
Lee SY, Kim GB, Carminati M et al. · Circulation. Cardiovascular interventions · (2026) · View on PubMed ↗
Impact of systemic-to-pulmonary artery shunt embolization on right heart hemodynamics in patients with bronchiectasis.
This clinical study enrolled 20 patients with bronchiectasis complicated by systemic-to-pulmonary artery shunt (SPS) and assessed right heart hemodynamics before and within 24–48 hours after SPS embolization using right heart catheterization and, when tolerated, cardiac MRI. The key finding was that SPS embolization led to measurable improvements in right heart hemodynamic parameters (including stroke volume, cardiac index/output, pulmonary artery pressure, and related measures) shortly after the procedure. Early hemodynamic improvement after embolization supports SPS embolization as a potentially effective intervention for bronchiectasis-associated shunt physiology.
Wu H, Jiang F, Guo L et al. · Journal of vascular and interventional radiology : JVIR · (2026) · View on PubMed ↗
Inhibition of late sodium current (INa) to prevent coronary MICROvascular dysfunction in patients presenting with ST-elevation myocardial infarction and multivessel disease: A phase IIb multicenter, randomized, controlled and open label study (INaMICRON).
This phase IIb multicenter randomized open-label trial (INaMICRON) studied whether early inhibition of the late sodium current with ranolazine, added to guideline-directed medical therapy, can prevent or improve coronary microvascular dysfunction in adults with ST-elevation myocardial infarction (STEMI) who underwent successful primary PCI and have at least one significant non-culprit lesion. The key finding is that the trial design will test ranolazine’s effect on microvascular function during the early post-infarction phase by comparing standard therapy versus standard therapy plus ranolazine in a 1:1 randomization. Scientifically and clinically, if effective, this strategy could reduce residual ischemia and improve recovery by targeting microvascular dysfunction rather than only epicardial revascularization.
Di Serafino L, Ciaramella L, De Rosa S et al. · International journal of cardiology · (2026) · View on PubMed ↗ · Free PDF ↗
Imaging methodology, acquisition protocols, and uncertainty calibration
Free-Breathing Dynamic, Regularized, Adaptive Cluster Optimization (DRACO) Cine Cardiac MRI in Atrial Fibrillation.
This prospective study tailored and evaluated DRACO (dynamic regularized adaptive clustering optimization) for free-breathing cardiac cine MRI in 20 patients with atrial fibrillation (AF) and 10 sinus-rhythm controls using 3.0T bSSFP ECG-gated segmented cine with sorted golden-step and real-time acquisition to handle both cardiac and respiratory motion. DRACO enabled high-quality, quantifiable cine imaging under free-breathing conditions in AF while simultaneously addressing cardiac/respiratory motion complexity. The approach could improve non–breath-hold cardiac MRI feasibility and measurement reliability for arrhythmia patients who cannot reliably perform breath-holds.
Ming Z, Pogosyan A, Dong X et al. · Journal of magnetic resonance imaging : JMRI · (2026) · View on PubMed ↗
Parasitically coupled 16-port massive MIMO antenna for mmWave applications.
This engineering study designed and tested a compact 16-port parasitically coupled massive MIMO antenna for mmWave applications, using five triangular parasitic elements plus a triangular feed-line element and impedance matching with a defected ground and stubs. The antenna was optimized to resonate at 40 GHz and demonstrated a feasible multiport massive MIMO implementation by replicating a single-element design with a modified ground plane. Such compact, high-frequency multiport antenna designs are significant for improving performance and integration in mmWave massive MIMO systems.
Mishra B, Sharma H, Misra NK et al. · Scientific reports · (2026) · View on PubMed ↗ · Free PDF ↗
Cardiac function and myocardial strain analysis at 7T using B1 shimming in comparison to 3T magnetic resonance imaging.
This volunteer study compared cardiac function and myocardial strain measurements at 7T versus 3T MRI using B1 shimming, acquiring cine long- and short-axis images in 10 participants. The key finding was that an efficient 7T workflow using a single B1 shim set derived from B1 mapping (single B1 phase shim vector applied across the exam) enabled assessment of volumetric and strain parameters while addressing transmit B1 inhomogeneity. Demonstrating workable B1-shimmed 7T cine/strain quantification is significant for advancing ultra-high-field cardiac MRI toward more reliable functional and mechanical measurements.
Jung B, Hundertmark M, Peters AA et al. · The international journal of cardiovascular imaging · (2026) · View on PubMed ↗ · Free PDF ↗
Modeling Aleatoric Uncertainty in Cardiac MRI Segmentation: Probabilistic Detection and Contour Regression.
This study investigated probabilistic cardiac MRI segmentation methods to model aleatoric (data) uncertainty for biomarker estimation of left and right ventricular ejection fraction (LVEF/RVEF) in the context of AI-based contour regression. It found that evaluating uncertainty at the biomarker level (not just average segmentation accuracy) is necessary for calibrated, reliable per-patient biomarker precision. This is significant because properly calibrated uncertainty can improve diagnostic trustworthiness and support safer clinical deployment of cardiac MRI segmentation models.
Zhao Y, Zhang Y, Tourais J et al. · IEEE transactions on medical imaging · (2026) · View on PubMed ↗ · Free PDF ↗
Segmental strain in chronic ischemic cardiomyopathy: clarifying the role of multiple-comparison adjustment and the clinical interpretation of limits of agreement.
This methodological correspondence studied how multiple-comparison adjustment affects interpretation of segmental left ventricular longitudinal strain in chronic ischemic cardiomyopathy, building on an intermodality comparison between feature-tracking CMR (FT-CMR) and 2D speckle-tracking echocardiography (2D-STE) in 55 stable patients. The key finding was that segment-level paired comparisons require explicit multiplicity handling and that limits of agreement should not be interpreted as implying interchangeability of the two modalities for individual or longitudinal assessment. This is significant because it clarifies how to correctly analyze and apply strain measurements to avoid overconfident clinical conclusions when comparing imaging techniques.
Malik MMUD, Jayaswal RP · Journal of cardiovascular imaging · (2026) · View on PubMed ↗ · Free PDF ↗
Non-cardiac biomedical/behavioral epidemiology (health systems, suicide, etc.)
Size-Resolved Microelectrical Effects of Fine Aerosol on Nocturnal Ozone: Evidence from Field Observations and Statistical Modeling.
This environmental field study investigated how particle electrical properties relate to nocturnal ozone (O3) enhancement under stable nighttime atmospheric conditions using observations in Xi’an from 2023–2025. Using generalized additive models (GAM), partial least squares structural equation modeling (PLS-SEM), and an interfacial contribution model, the authors assessed associations between particle charge-to-mass ratio (CMR) and nocturnal O3 variations. The results suggest that particulate electrical characteristics may contribute to nocturnal O3 chemistry beyond meteorological transport alone, informing more complete atmospheric models.
Wang Y, Zhang L, Li J et al. · Environmental research · (2026) · View on PubMed ↗
Current landscape of paediatric and young adult cardio-oncology care in Latin America.
This cross-sectional survey characterized the current landscape of pediatric/adolescent cardio-oncology care across Latin America, focusing on workforce training, clinical infrastructure, diagnostic resources, follow-up strategies, and research capacity. The study found substantial gaps and variability in program implementation and resources across the region. Mapping these deficiencies is clinically significant because it identifies where capacity-building and standardized care pathways are most needed for childhood cancer survivors at elevated lifetime cardiovascular risk.
Stelmaszewski EV, Biancolini J, Gonzalez Ortiz A et al. · Cardiology in the young · (2026) · View on PubMed ↗
Nurses’ Clinical Decision-Making During Peripherally Inserted Central Catheter Dressing Application and Removal: A Qualitative Study.
This qualitative study investigated nurses’ clinical decision-making during PICC dressing application and removal using the Think Aloud method with registered nurses in two Australian quaternary cancer care wards (adult and paediatric). The key finding was that nurses’ reasoning could be mapped to Dual Process Theory and analyzed via Framework Analysis, revealing how they balance rule-based procedures with experiential judgment during dressing-related tasks. The study is significant because it can inform targeted training and standardization to improve safety and consistency of PICC care in oncology settings.
Larsen EN, Wickins J, Marsh N et al. · Seminars in oncology nursing · (2026) · View on PubMed ↗ · Free PDF ↗
Rates, Timing and Correlates of Suicide in Norwegian Prisons: A 23-Year National Cohort Study.
This national cohort study examined suicide timing and correlates among people incarcerated in Norwegian prisons from 2000–2022 using linked registry data (nPRIS). The key finding was that suicide risk varies by imprisonment timing and is associated with sociodemographic, criminological, and clinical factors. The clinical significance is that identifying when risk is highest and which factors cluster with suicide can inform targeted prevention strategies within correctional settings.
Bukten A, Mehlum L, Lokdam NT et al. · Archives of suicide research : official journal of the International Academy for Suicide Research · (2026) · View on PubMed ↗ · Free PDF ↗
Relative importance of weight gain among cardiometabolic risk factors in the development of metabolic dysfunction-associated steatotic liver disease: An observational study using large-scale health examination data.
This retrospective cohort observational study used large-scale health examination data to determine how weight gain compares with other cardiometabolic risk factors in driving incident metabolic dysfunction-associated steatotic liver disease (MASLD) in 7,687 individuals without steatotic liver disease at baseline. It assessed baseline cardiometabolic risk factors and 5-year weight changes to estimate associations with incident MASLD and to identify a threshold of weight gain linked to increased risk relative to other risk factors. The significance is that it clarifies which obesity-related metric (e.g., BMI and waist circumference) and how much weight gain most strongly predicts MASLD development, supporting targeted prevention.
Sahara K, Yokoyama S, Ito T et al. · Internal medicine (Tokyo, Japan) · (2026) · View on PubMed ↗ · Free PDF ↗
Generated automatically on June 18, 2026. Covers PubMed articles published June 11, 2026 – June 18, 2026. Summaries are AI-generated; always consult the original publication for clinical or research decisions.