What’s New in Cardiac MRI?

July 04, 2026 · 93 articles · 15 research themes · covering June 27, 2026 – July 04, 2026

Overview

This week’s digest is dominated by a clear push toward earlier, more precise cardiovascular risk stratification using advanced imaging and quantitative biomarkers. Across myocarditis/pericarditis, hypertrophic cardiomyopathy, coronary microvascular dysfunction/MINOCA, and heart failure staging, studies converge on the idea that “subclinical” disease can be detected before overt outcomes—often with cardiac MRI (CMR) mapping, strain, and tissue characterization—then followed longitudinally to guide intensity of monitoring and management. Examples include serial CMR for predicting long-term events in acute myocarditis, CMR-derived left atrioventricular coupling index (LACI) for atrial fibrillation/stroke and sudden cardiac death risk in HCM, and microvascular-resistance or CMR-defined microvascular obstruction as prognostic markers after STEMI.

A second major theme is the maturation of imaging workflows—both interpretive and technical—toward scalability and consistency. Multiple papers address reproducibility and harmonization (e.g., stress-test ischemia interpretation variability, automated CMR plane prescription, cross-modal strain agreement), while others highlight AI-driven automation (segmentation, reconstruction, federated learning, and even large-language-model interpretation of standardized CMR descriptions). In parallel, technical advances (low-field CMR, improved sodium quantification, QSM motion compensation, and faster 4D flow reconstruction) aim to make high-quality quantitative imaging more accessible and robust across sites and scanner conditions.

Finally, the digest reflects a broader “precision cardiology” direction: endotype-informed treatment strategies (eplerenone targeting coronary microvascular dysfunction in MINOCA/nonischemic injury), refined selection frameworks for transcatheter mitral repair, and multimodality diagnostic frameworks for complex inflammatory and infiltrative diseases such as cardiac sarcoidosis and amyloidosis. Even when evidence is presented as case reports or reviews, the recurring message is the same—integrate tissue, function, and clinical phenotype to reduce diagnostic uncertainty and better match therapies to the underlying mechanism.

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Myocarditis & Pericarditis (Inflammatory Myopericardial Syndromes)

Prognosis of acute myocarditis beyond hospitalization: Results of a long-term prospective study.

This prospective single-center observational study followed 158 patients (mean age 32±12 years; 12.7% female) hospitalized for acute myocarditis between 2007 and 2022 to assess long-term prognosis beyond discharge. Over follow-up, severe complications such as cardiogenic shock or arrhythmic storm occurred in 3.6%, and outcomes were evaluated using treadmill testing, Holter monitoring, and echocardiography with Cox regression to identify prognostic factors. The findings are significant for counseling and long-term management of acute myocarditis patients using structured post-discharge clinical and functional testing.

de Freitas Vilela MM, Martins AM, Cazeiro D et al. · Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology · (2026) · View on PubMed ↗

Myocardial Calcification as a Rare Cardiac Sequela: When Sepsis Leaves Its Mark.

This case report described a 33-year-old woman who developed myocardial calcification after severe sepsis from disseminated Streptococcus pneumoniae, with initial septic shock and septic shock–associated myocardial injury suggested by marked troponin elevation and normal coronary angiography. The key finding was that repeat chest computed tomography four weeks later showed new extensive left ventricular and papillary muscle calcifications consistent with sepsis-related myocardial calcification. The clinical significance is heightened awareness that severe sepsis can leave rare but persistent structural cardiac sequelae detectable on imaging.

El-Hamad A, Sene PM, El Mehdi El Yamani M et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗

A 12-week Exercise Intervention Among Older Adults With Chronic Coronary Syndrome: Changes and Associations of Movement Behaviors and Cardiovascular Risk Factors.

This 12-week group exercise intervention studied 35 older adults with chronic coronary syndrome (CCS) (mean age ~69.5 years; 82.9% men) using 7-day accelerometry to quantify movement behaviors, alongside cardiopulmonary exercise testing (VO2peak), cardiometabolic risk (CMR) blood markers, and serum brain-derived neurotrophic factor (BDNF). The intervention produced changes in movement behaviors and these changes were associated with improvements in VO2peak and/or CMR and BDNF from baseline to follow-up (reported through 9 months). These findings support movement-behavior–targeted exercise as a clinically meaningful strategy to improve cardiorespiratory fitness and cardiometabolic and neurotrophic biomarkers in CCS patients.

Ullrich A, Bahls M, Voigt L et al. · European journal of sport science · (2026) · View on PubMed ↗ · Free PDF ↗

Analysis of cardiac magnetic resonance characteristics in patients with ejection fraction preserved heart failure.

This retrospective CMR study analyzed 117 HFpEF patients, 65 healthy controls, and 62 high-risk individuals, and used a follow-up cohort (n=228) to assess prognosis, focusing on epicardial adipose tissue (EAT) volume and its relationship to left ventricular function. EAT volume measured by cardiac MRI was associated with left ventricular strain and patient outcomes (heart failure readmission or all-cause death). These findings suggest that CMR-quantified EAT may serve as a prognostic biomarker in HFpEF.

Zhang Y, Li Y, Yang X et al. · Clinical radiology · (2026) · View on PubMed ↗

Cardiac magnetic resonance-derived atrioventricular coupling index for predicting left ventricular reverse remodeling in dilated cardiomyopathy.

This retrospective study evaluated whether a cardiac MRI-derived left atrioventricular coupling index (LACI) predicts left ventricular reverse remodeling (LVRR) in 64 hospitalized patients with dilated cardiomyopathy (DCM) receiving standardized guideline-directed therapy. Patients were classified into LVRR versus non-LVRR groups using echocardiographic criteria at one year, and multivariable models tested incremental predictive value of LACI (and separately left atrial strain or left ventricular strain). The study supports CMR-derived LACI as a potential imaging biomarker to forecast therapeutic reverse remodeling in DCM.

Ke J, Zhang C, Wang X et al. · Clinical radiology · (2026) · View on PubMed ↗

Simultaneous multi-slice Cardiac Diffusion Tensor Imaging with variable CAIPIRINHA shifts and artefact-aware AI.

This technical imaging study introduced ORCAS, a framework combining variable CAIPIRINHA shifts with artefact-aware AI reconstruction to accelerate simultaneous multi-slice cardiac diffusion tensor imaging (cDTI). By decohering inter-slice leakage artefacts across repetitions and improving reconstruction quality, ORCAS aims to reduce the need for long multi-repetition averaging while maintaining adequate signal-to-noise ratio for myocardial microstructure mapping. The work is significant for making cDTI more clinically feasible by shortening acquisition times without sacrificing microstructural information.

Tänzer M, Lim EJ, Qiu HH et al. · Medical image analysis · (2026) · View on PubMed ↗ · Free PDF ↗

Unexplained Supraventricular Tachycardia and Myocardial Injury After Bitter Orange Supplement Use in a Young Woman.

This case report studied a 38-year-old woman who developed supraventricular tachycardia and myocardial injury after 1 week of bitter orange (Citrus aurantium) weight-loss supplement use containing p-synephrine. She had ECG-confirmed supraventricular tachycardia responsive to 6 mg IV adenosine and a marked rise in high-sensitivity troponin I (17.9 to 1,395.7 ng/L) with CT pulmonary angiography excluding pulmonary embolism. The findings are clinically significant because they document sympathomimetic supplement–associated arrhythmia and acute myocardial injury, supporting caution and prompt cardiac evaluation after bitter orange exposure.

Plaitis A, Grigoraki E, Karakosta M et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗

A case report of nonrheumatic myocarditis following group G streptococcus pharyngitis.

This case report studied a 22-year-old man who developed nonrheumatic myocarditis after group G streptococcal pharyngitis. Cardiac magnetic resonance imaging showed focal myocardial hyperintensity on T2-weighted imaging with corresponding elevated T2 values, supporting myocarditis after a rare bacterial trigger. The clinical significance is that it expands recognition of post-bacterial myocarditis presentations and demonstrates CMR T2-based findings that can support diagnosis and management.

Perkins SJ, Lim JGS, Gans C et al. · Radiology case reports · (2026) · View on PubMed ↗ · Free PDF ↗

Cardiac MRI monitoring in acute myocarditis: predicting outcomes through serial imaging.

This prospective multicenter study followed patients with MRI-confirmed acute myocarditis with serial cardiac MRI at baseline (median 6 days after symptom onset), short-term (median 36 days), and long-term (median 392 days) to determine how changes in MRI parameters predict major adverse cardiac events (MACE) at 5-year follow-up. Serial evolution of cardiac MRI findings (including mapping-derived parameters) was evaluated for prognostic value regarding later MACE. The results support using longitudinal cardiac MRI monitoring to risk-stratify acute myocarditis and potentially guide follow-up intensity and management.

Palmisano A, Rancoita PMV, Gatti M et al. · European radiology · (2026) · View on PubMed ↗

Bright Ferritin for Non-Invasive MRI Monitoring of the Fate of Transplanted hPSC-Cardiomyocytes in the Infarcted Rat Heart.

The study tested whether “bright ferritin” MRI can noninvasively track transplanted human pluripotent stem cell–derived cardiomyocytes (hPSC-CMs) in the infarcted rat heart over time. Ferritin-overexpressing hPSCs differentiated into cardiomyocytes were injected into rat left ventricular myocardium, and the transplanted cells were imaged at 3 T over 8 weeks in both healthy and infarcted hearts, with MnCl2 used for on-demand recall. This provides a translational imaging platform to monitor cell fate and persistence after cardiac cell therapy.

Zhuang K, Alibhai FJ, Qiang B et al. · Magnetic resonance in medicine · (2026) · View on PubMed ↗ · Free PDF ↗

Myocarditis and pericarditis in focus: A critical appraisal of the 2025 ESC vs ACC position statements from the Italian society of cardiology working group on cardiomyopathies and pericardial diseases.

This article critically appraises the 2025 ESC position statement versus the 2024–2025 ACC consensus documents for myocarditis and pericarditis, focusing on diagnostic and management approaches in clinical practice. It finds broad convergence that early, accurate diagnosis—often using cardiac magnetic resonance (CMR) rather than immediate biopsy in stable, uncomplicated acute myocarditis—is central, while the ESC proposes a unified “inflammatory myopericardial syndrome (IMPS)” framework and the ACC uses a novel four-stage clinical classification of myocarditis. The significance is that these differing classification and diagnostic pathways may affect how patients with acute myocarditis/pericarditis are stratified and treated across Europe and the US.

Imazio M, Collini V, Merlo M et al. · Trends in cardiovascular medicine · (2026) · 1 citations · View on PubMed ↗ · Free PDF ↗

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Hypertrophic Cardiomyopathy (HCM) Risk Stratification & Remodeling

Trileaflet mitral valve in hypertrophic obstructive cardiomyopathy: A rare anatomical variant requiring surgical intervention.

This case report studied a 68-year-old woman with hypertrophic obstructive cardiomyopathy (HOCM) presenting with palpitations and left ventricular outflow tract obstruction. Multimodal imaging (cardiac magnetic resonance and echocardiography) identified a rare “trileaflet mitral valve” variant with anterior leaflet restriction and a clefted posterior leaflet causing severe mitral regurgitation and systolic anterior motion, and symptoms persisted despite beta-blockers. The clinical significance is that unusual mitral valve anatomy in HOCM may require surgical intervention when medical therapy fails and anatomy-driven obstruction/regurgitation drives prognosis.

Kumar UA, Sitaranjan DR, Taghavi FJ · Perfusion · (2026) · View on PubMed ↗

Clinical Course and Predictors of Heart Failure in Asymptomatic Obstructive Hypertrophic Cardiomyopathy.

This multicenter retrospective cohort study analyzed 341 asymptomatic patients with obstructive hypertrophic cardiomyopathy (NYHA class I, LVEF >50%, LVOT gradient ≥30 mmHg) across four centers (2003–2023) to identify predictors of progression to symptomatic heart failure. The key finding was that specific baseline clinical and echocardiographic features were associated with subsequent development of heart failure in this initially asymptomatic population. Scientifically, it refines risk stratification for obstructive HCM and supports earlier intervention targeting patients most likely to deteriorate.

Schulz A, Maron MS, Peng LW et al. · Journal of the American Heart Association · (2026) · View on PubMed ↗ · Free PDF ↗

Assessment of left atrioventricular coupling index in hypertrophic cardiomyopathy: improving risk stratification with cardiac magnetic resonance (CMR).

This retrospective study assessed the prognostic value of the left atrioventricular coupling index (LACI), defined as left atrial end-diastolic volume divided by left ventricular end-diastolic volume, in 2,240 patients with hypertrophic cardiomyopathy (HCM) using clinical data and cardiac MRI parameters including LGE and left ventricular ejection fraction (LVEF). LACI improved prediction of sudden cardiac death (SCD) events and provided incremental prognostic information beyond guideline-based risk models. These results suggest that CMR-derived LACI could refine SCD risk stratification in HCM.

Zhang D, Qian Y, Gu Z et al. · Clinical radiology · (2026) · View on PubMed ↗

Discordant Cardiomyopathy Phenotypes in Siblings With Homozygous FKRP c.1100T>C.

This case report described two South African Afrikaner siblings with homozygous FKRP c.1100T>C (p.Ile367Thr) who had discordant cardiac phenotypes. The brother developed progressive dilated cardiomyopathy with reduced LVEF and extensive late gadolinium enhancement over 7 years, illustrating variable cardiac involvement despite the same FKRP genotype. The report emphasizes genotype–phenotype divergence in FKRP-related limb-girdle muscular dystrophy R9 and the need for individualized cardiac surveillance.

Mahon N, Coad S, Kiamanesh O · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗

FDG PET for cardiac sarcoidosis: Protocol optimization, quantification, pitfalls, and multimodality imaging integration.

This 2026 review summarized how FDG PET is used for cardiac sarcoidosis (CS) within a multimodality diagnostic framework integrating echocardiography, cardiac MRI, and PET. It highlighted protocol optimization, quantification approaches, common pitfalls, and how PET findings are integrated with other imaging to improve diagnosis and management of CS. The review is clinically significant because standardized FDG PET practices can reduce false results and better support risk assessment for heart failure, conduction disease, ventricular arrhythmias, and sudden cardiac death.

Wopperer SB, Kronzer E, Ivare J et al. · Seminars in nuclear medicine · (2026) · 1 citations · View on PubMed ↗

Left atrioventricular coupling index and atrial fibrillation and stroke in hypertrophic cardiomyopathy: a CMR study.

This CMR-based retrospective study evaluated whether the left atrioventricular coupling index (LACI), which combines left atrial size with left ventricular filling properties, predicts new-onset atrial fibrillation (AF) and thromboembolic events (TIA or ischemic stroke) in 287 patients with hypertrophic cardiomyopathy (HCM). The key finding is that LACI was assessed as an AF/stroke risk marker in HCM because existing AF prediction models perform poorly in this population, implying LACI may better capture atrial remodeling relevant to events. Clinically, if validated, LACI could improve risk stratification for AF and stroke in HCM patients beyond conventional imaging and clinical predictors.

De Raffele M, Casas G, Delgado V et al. · Revista espanola de cardiologia (English ed.) · (2026) · 1 citations · View on PubMed ↗

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Coronary Microvascular Dysfunction (CMD) & MINOCA/Nonischemic Injury

Stratified Medicine with Eplerenone for Myocardial Infarction or Injury and No obstructive Coronary Arteries: A Registry-Based Basket Trial.

This registry-based basket trial evaluated a stratified medicine approach for MINOCA/nonischemic myocardial injury by assessing the prevalence and prognostic implications of coronary microvascular dysfunction and then testing endotype-informed treatment with eplerenone in patients with suspected MINOCA. The study’s key finding was that coronary microvascular dysfunction is sufficiently prevalent in this population to enable stratification, and that patients with this endotype are targeted for eplerenone therapy. Scientifically and clinically, it supports a precision-cardiology framework using coronary microvascular dysfunction to guide mineralocorticoid receptor antagonist therapy in MINOCA/nonischemic myocardial injury.

Sykes R, Tan D, McKinley G et al. · American heart journal · (2026) · View on PubMed ↗ · Free PDF ↗

Stress native mapping does not distinguish patients with previous myocardial infarction with non-obstructive coronary arteries from healthy volunteers.

This study investigated whether stress native T1 and T2 mapping on 1.5T cardiac MRI can distinguish patients with previous myocardial infarction with non-obstructive coronary arteries (MINOCA) from healthy volunteers. In 15 MINOCA patients with normal CMR and matched controls, adenosine stress native T1/T2 and quantitative perfusion mapping did not differentiate the groups. The findings indicate that stress native mapping alone may be insufficient for identifying microvascular dysfunction in this MINOCA subgroup, guiding future diagnostic strategies.

Andersson DF, Johansson RS, Tornvall P et al. · Clinical physiology and functional imaging · (2026) · View on PubMed ↗ · Free PDF ↗

Impact of Microvascular Obstruction on Left Atrial and Ventricular Myocardial Deformation and In-hospital Complications in Reperfused ST-segment Elevation Myocardial Infarction Patients.

This retrospective CMR study examined how microvascular obstruction (MVO), defined on late gadolinium enhancement (LGE) as a hypo-enhanced core within hyper-enhanced myocardium, affects left atrial and ventricular deformation and in-hospital complications in 95 reperfused STEMI patients undergoing CMR within 7 days. The key finding is that MVO presence is associated with worse myocardial deformation parameters and higher in-hospital complication rates compared with patients without MVO. Scientifically and clinically, this supports using CMR LGE-defined MVO as an early prognostic marker to risk-stratify reperfused STEMI patients.

Cau R, Pinna A, Bassareo PP et al. · Journal of thoracic imaging · (2026) · View on PubMed ↗

A Stepwise Multimodality Imaging Approach to Out-of-Hospital Cardiac Arrest in Cystic Fibrosis.

This case report described a 25-year-old man with cystic fibrosis who developed out-of-hospital cardiac arrest with ventricular fibrillation during a pulmonary exacerbation and was evaluated with multimodality imaging after resuscitation. The key finding is that the diagnostic workup (including ECG, high-sensitivity troponin, and transthoracic echocardiography showing regional wall motion abnormalities and mildly reduced left ventricular ejection fraction) helped characterize the cardiac cause in a non–ST-elevation OHCA context. The significance lies in highlighting an imaging-driven diagnostic pathway for young OHCA patients with low pretest probability of atherosclerotic disease.

Frittella S, Iuvara G, Angeli F et al. · The American journal of cardiology · (2026) · View on PubMed ↗ · Free PDF ↗

Detection of Coronary Microvascular Dysfunction in Diabetic Mice Using Arterial Spin Labeling Cardiac MRI: A Multimodality Imaging Comparison.

This prospective animal study compared arterial spin labeling cardiac MRI (ASL-MRI) and transthoracic echocardiography (TTE) for detecting coronary microvascular dysfunction (CMD) in type 1 and type 2 diabetic mouse models, including early-stage 8-week T2DM. The key finding is that ASL-MRI and TTE provide different performance for CMD assessment, and functional indices from imaging correlate with histological microvascular and myocardial remodeling. Scientifically, this supports ASL-MRI as a noninvasive tool for CMD characterization and helps determine which modality best reflects underlying pathology in diabetic disease models.

Miao Q, Shi Y, Li B et al. · Journal of magnetic resonance imaging : JMRI · (2026) · 1 citations · View on PubMed ↗

Prognostic implications of coronary microvascular dysfunction in STEMI with and without metabolic syndrome.

This multicenter prospective study examined prognostic implications of coronary microvascular dysfunction (CMD) in ST-segment elevation myocardial infarction (STEMI) patients with versus without metabolic syndrome (MetS), using an angiography-derived index of microcirculatory resistance to quantify CMD. It finds that the study was designed to clarify how CMD influences cardiovascular outcomes after primary percutaneous coronary intervention (PCI) differently depending on MetS status, addressing uncertainty about CMD’s incremental prognostic value in MetS. Scientifically and clinically, determining whether CMD measured by microcirculatory resistance predicts worse outcomes in MetS-stratified STEMI could refine post-PCI risk assessment and guide targeted management.

Guo Q, Guo Y, Shi S et al. · Revista espanola de cardiologia (English ed.) · (2026) · View on PubMed ↗

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Heart Failure Staging, Prognosis & Therapeutic Strategies

Diagnostic Tests for Stage B Heart Failure.

This review synthesized guideline- and study-based evidence on diagnostic testing for Stage B heart failure (SBHF) in patients with structural heart disease but no overt symptoms. It found that transthoracic echocardiography—particularly speckle-tracking echocardiography for subclinical myocardial remodeling—and circulating biomarkers such as natriuretic peptides and high-sensitivity cardiac troponins improve detection of early myocardial injury before symptom onset. Clinically, this supports earlier risk stratification and monitoring strategies for SBHF using accessible imaging and blood-based biomarkers.

Dang HNN, Luong TV, Huynh Q et al. · Current cardiology reports · (2026) · View on PubMed ↗

Polypill for heart failure with reduced ejection fraction: the POLY-HF randomized trial.

The POLY-HF randomized trial studied whether a once-daily heart failure with reduced ejection fraction (LVEF ≤40%) polypill combining metoprolol succinate (25/50/100/150 mg), spironolactone 12.5 mg, and empagliflozin 10 mg improves outcomes compared with rapid uptitration of individual guideline-directed medical therapy in adults with HFrEF at two centers with a predominantly underserved population. The key finding was that the polypill strategy improved cardiac function compared with enhanced usual care (individual rapid uptitration), supporting feasibility of simplified implementation. Clinically, this suggests a practical medication-delivery approach to increase guideline therapy uptake and improve cardiac outcomes in underserved HFrEF patients.

Pandey A, Keshvani N, Rizvi SK et al. · Nature medicine · (2026) · View on PubMed ↗

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Mitral Valve Disease & Transcatheter Repair (M-TEER)

An integrative approach to patient selection for mitral transcatheter edge-to-edge repair in secondary mitral regurgitation.

This review synthesized evidence and proposed a structured patient-selection framework for mitral transcatheter edge-to-edge repair (M-TEER) in secondary mitral regurgitation (SMR) despite guideline-directed medical therapy. It concluded that differences in outcomes between MITRA-FR and COAPT are largely explained by echocardiographic selection and left-ventricular remodeling, implying that SMR severity should be interpreted relative to ventricular size and remodeling. The clinical significance is improved identification of patients most likely to benefit from M-TEER using multimodality imaging and trial-informed proportionality concepts.

Brusosa M, Flores-Umanzor E, Horlick E · Current opinion in cardiology · (2026) · View on PubMed ↗

Sex-based differences in mitral and tricuspid valve disease in the era of transcatheter therapies: a contemporary review.

This contemporary review synthesized evidence on sex-based differences in mitral and tricuspid valve disease as transcatheter therapies expand. The key finding is that biological sex influences disease epidemiology, pathophysiology, imaging assessment, and procedural outcomes, which can affect clinical decision-making in transcatheter valve care. The significance is that incorporating sex-specific considerations may improve diagnosis and optimize management strategies for mitral and tricuspid valve disorders.

Oletu H, Irivbogbe OA, Akhtar Y · Current problems in cardiology · (2026) · View on PubMed ↗

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Cardiac Sarcoidosis (EMB/FDG PET/Multimodality Diagnosis)

Multidisciplinary approach in cardiac sarcoidosis: to biopsy or not?

This narrative review assessed the contemporary role of endomyocardial biopsy (EMB) in a multidisciplinary diagnostic approach to cardiac sarcoidosis (CS). It highlighted that EMB, historically considered a diagnostic gold standard, has limited sensitivity with false negatives and procedural risks, leading to increasing reliance on noninvasive imaging while still considering when tissue diagnosis is necessary. Clinically, the review supports a more tailored “to biopsy or not” strategy based on imaging findings, clinical phenotype, and the need for histologic confirmation.

Pericao A, Sharma R · Current opinion in pulmonary medicine · (2026) · View on PubMed ↗

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Cardiac Amyloidosis (ATTR/AL) Imaging Biomarkers & Prognosis

Incremental Prognostic Value of Cardiac Magnetic Resonance Beyond Biomarker Staging in Transthyretin Cardiac Amyloidosis.

This multicenter retrospective cohort study evaluated whether adding cardiac magnetic resonance (CMR) parameters to National Amyloidosis Center (NAC) biomarker staging improves prognostic prediction in 266 patients with transthyretin cardiac amyloidosis (ATTR-CA). Incorporating CMR-derived predictors into the NAC stage model provided incremental prognostic value for time to death and was assessed for potential utility in guiding evaluation for advanced heart failure therapies and emerging disease-modifying treatments. The findings suggest CMR can refine risk stratification beyond serum biomarker staging in ATTR-CA, potentially improving patient selection for high-impact therapies.

Chiou T, Minga I, Subashchandran V et al. · European heart journal. Cardiovascular Imaging · (2026) · View on PubMed ↗

Extracellular Volume Mapping by Cardiac MRI Predicts Sudden Cardiac Death in AL Amyloidosis: A South Asian Cohort Study.

This ambispective South Asian cohort study assessed whether cardiac MRI extracellular volume (ECV) measured at diagnosis predicts sudden cardiac death in 188 patients with AL amyloidosis, using serum free light chain restriction and biopsy-proven amyloidosis/cardiac amyloidosis phenotype for inclusion. ECV was calculated from cardiac T1 mapping, with normal ECV defined as <25%, and the study evaluated the association between abnormal ECV (≥25%) and subsequent sudden cardiac death risk. If confirmed, ECV mapping could serve as a noninvasive prognostic biomarker to identify AL amyloidosis patients at higher risk for sudden cardiac death.

Pattnaik SA, Ahamed H, Gutjahr G et al. · Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion · (2026) · View on PubMed ↗ · Free PDF ↗

The Diagnostic and Prognostic Value of Multi-Chamber Strain Analysis by Cardiac MRI in Amyloidosis.

This retrospective study evaluated multi-chamber myocardial strain measured by cardiac MRI in 47 patients with cardiac amyloidosis, and correlated strain with native T1 mapping and Query Amyloid Late Enhancement (QALE) as well as late gadolinium enhancement (LGE), with major adverse cardiovascular events (MACE) assessed on follow-up. Multi-chamber strain parameters showed diagnostic/prognostic utility and were correlated with amyloid-specific CMR measures (native T1/QALE and LGE). These findings support multi-chamber strain as an additional CMR biomarker to improve risk stratification in cardiac amyloidosis beyond conventional mapping and LGE.

Chilkuri SK, Dsouza R, Houbois C et al. · Journal of thoracic imaging · (2026) · View on PubMed ↗

Apical Hypertrophic Cardiomyopathy in ATTR Val142Ile Carrier: When Genes and Phenotype Diverge.

This case report described a 61-year-old African-American man with longstanding apical hypertrophic cardiomyopathy (ApHCM) who was found to carry the pathogenic transthyretin (TTR) variant Val142Ile (V142I). Despite genotype positivity, technetium-99m pyrophosphate scintigraphy (H/CL 1.01, visual grade 0) argued against transthyretin cardiac amyloidosis (ATTR-CM), and cardiac MRI confirmed apical-predominant hypertrophy with patchy late gadolinium enhancement consistent with ApHCM rather than ATTR-CM. The report underscores that TTR V142Ile can show incomplete penetrance and that CMR plus bone-avid scintigraphy are critical to distinguish ATTR-CM from phenocopies to guide management.

Khayat O, Moumneh MB, Salman O et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗

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Ventricular Arrhythmias, VT Ablation & Sudden Cardiac Death Risk

Revisiting the Link Between Substrate and Ventricular Tachycardia Rate: The Critical Role of Conduction Isthmus Structure and Function.

This prospective cohort study examined how substrate features relate to ventricular tachycardia (VT) rate in 62 patients undergoing scar-related VT ablation, using high-density electroanatomical mapping and late gadolinium-enhanced cardiac MRI. The key finding was that conduction isthmus structure and function (isthmus-specific substrate metrics such as activation timing and deceleration zone characteristics) predicted VT rate better than global substrate metrics alone. This is significant because it can refine risk stratification and ablation targeting by focusing on local conduction isthmuses that govern VT dynamics.

Guichard JB, Castrillo-Golvano L, Molero-Pereira S et al. · Heart rhythm · (2026) · View on PubMed ↗ · Free PDF ↗

Treatment of Premature Ventricular Contractions: A Review of Medical Therapy, Catheter Ablation, and Emerging Treatments.

This article reviewed medical therapy, catheter ablation, and emerging treatments for premature ventricular contractions (PVCs) in patients with and without structural heart disease. The key finding was that treatment selection should be individualized based on symptom burden, PVC frequency, ventricular function, and underlying myocardial disease, with catheter ablation and newer approaches reserved for higher-risk or refractory cases. Clinically, it supports evidence-based decision-making to prevent PVC-induced cardiomyopathy and reduce arrhythmia-related morbidity.

Elattar S, Hodhod A, Basha NR et al. · Cardiology in review · (2026) · View on PubMed ↗

A Case of Brugada Syndrome… or Something Else? Behind Type 1 Brugada Pattern.

This clinical case report evaluated a 51-year-old man with syncope during febrile illness who had a transient spontaneous type-1 Brugada pattern on ECG. Holter monitoring demonstrated multifocal ventricular ectopy including non-sustained ventricular tachycardia (NSVT), prompting consideration that the presentation might reflect an alternative diagnosis beyond classic Brugada syndrome. The case underscores that overt arrhythmogenic substrate or myocardial disease should trigger broader diagnostic workup when Brugada-like ECG patterns are transient.

Scarà A, Borrelli A, Romano S et al. · Clinical case reports · (2026) · View on PubMed ↗ · Free PDF ↗

Filamin C Genetic Cardiomyopathy Presenting as Acute Myocardial Injury.

This JACC Case Reports report described a 46-year-old man with acute myocardial injury characterized by markedly elevated high-sensitivity troponin and nonischemic imaging findings on cardiac MRI. Cardiac MRI showed extensive ring-like subepicardial late gadolinium enhancement involving 10 left ventricular segments without myocardial edema, and genetic testing identified a pathogenic FLNC (filamin C) variant; follow-up at 4 months showed persistent fibrosis with preserved ventricular function and no arrhythmias. The case supports FLNC-related genetic cardiomyopathy as a cause of nonischemic troponin elevation and highlights ring-like LGE as a diagnostic clue.

Alexandrino FB, Curtis B, Nguyen C et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗

Malignant Mitral Valve Prolapse With Life-Threatening Ventricular Arrhythmias: A Multidisciplinary Team-Guided Stepwise Management.

This case report studied a 45-year-old woman with bileaflet myxomatous mitral valve prolapse (MVP) and mitral annular disjunction who developed malignant ventricular arrhythmias despite only mild mitral regurgitation and no detectable myocardial fibrosis on cardiac magnetic resonance (CMR). She experienced recurrent ventricular fibrillation and multiple ICD shocks, raising the question of how to identify imminent risk when severe MR or fibrosis is absent. The report is scientifically and clinically significant because it supports a multidisciplinary, stepwise risk-management approach using combined electrical and mechanical markers rather than relying solely on fibrosis or MR severity.

Javadi N, Jahangir A, Galazka P et al. · JACC. Case reports · (2026) · 1 citations · View on PubMed ↗ · Free PDF ↗

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Cardiac Imaging Biomarkers & Quantitative Strain/Mapping (General)

Diagnostic and Prognostic Utility of Mitral Annular Plane Systolic Excursion: A Systematic Review and Meta-Analysis.

This systematic review and meta-analysis evaluated the diagnostic and prognostic utility of mitral annular plane systolic excursion (MAPSE) across studies using echocardiographic and other imaging modalities. It found that MAPSE, a fast and easily automated measure of longitudinal mitral annular displacement, has evidence supporting both diagnostic performance and prognostic association, with good agreement reported versus cardiovascular magnetic resonance and feasibility across transthoracic, transesophageal, and cardiac CT contexts. The clinical significance is that MAPSE could be incorporated more routinely for risk assessment even though major imaging guidelines have not yet universally recommended it.

Falconer D, Fröjdh F, Wyeth N et al. · Journal of the American Heart Association · (2026) · View on PubMed ↗ · Free PDF ↗

Integrative Observational and Genetic Evidence From the UK Biobank Supports Carotid Intima-Media Thickness as a Window Into Cardiac Remodeling.

This UK Biobank integrative observational and genetic study examined 46,102 participants with carotid ultrasound and cardiac magnetic resonance imaging to test whether carotid intima-media thickness (cIMT) reflects cardiac remodeling and shares genetic architecture with cardiovascular disease. It found phenotypic and genetic associations linking higher cIMT to cardiac structural/functional traits and cardiovascular disease risk, supporting cIMT as a “window” into early cardiac remodeling. The significance is that cIMT may help identify individuals at risk for subclinical cardiac changes using a noninvasive vascular measure plus genetic context.

Chong SH, Saccoh AF, van Vugt M et al. · Journal of the American Heart Association · (2026) · View on PubMed ↗ · Free PDF ↗

CMR Reveals the Influence of Trigger and Classification on the Myocardial Tissue Response in Takotsubo Syndrome.

This CMR study investigated how trigger type and the InterTAK classification (including the newer primary vs secondary distinction) relate to myocardial tissue response in Takotsubo syndrome (TTS). The key finding was that CMR measures of left ventricular function, myocardial edema, and myocardial injury differed according to triggering factor and between primary and secondary TTS categories beyond the established InterTAK framework. This is significant because it supports a more mechanistic, imaging-informed classification of TTS that may better predict pathophysiology and outcomes.

Gotschy A, Cammann VL, Schweiger V et al. · Circulation. Cardiovascular imaging · (2026) · View on PubMed ↗

Comparison of Cardiac MR with PET CT in Evaluation of Myocardial Viability: Single-Center Experience.

This prospective single-center study compared cardiac MRI (including end-diastolic wall thickness [EDWT], regional wall motion abnormalities, and late gadolinium enhancement [LGE]) with PET-CT for myocardial viability assessment in 28 adult patients with PET-CT perfusion/metabolism matched or mismatched defects. Cardiac MRI parameters were evaluated against PET-CT as the gold standard for identifying infarcted/viable myocardium, using both manual and semiautomatic EDWT measurements. The work supports MRI-based viability assessment strategies that could reduce reliance on PET-CT while maintaining diagnostic accuracy.

Arafath MY, Debi U, Singhal M et al. · The Indian journal of radiology & imaging · (2026) · View on PubMed ↗ · Free PDF ↗

Cardiac MRI Identifies Subclinical Myocardial Tissue Abnormalities in Individuals With Hepatitis C Regardless of Myocardial Damage Markers or Fibrosis Stage.

This study used 3T cardiac magnetic resonance (CMR) to measure cardiac extracellular volume (ECV) fraction in 10 untreated individuals with chronic hepatitis C virus (HCV) infection prior to therapy, comparing results with age-matched healthy volunteers. HCV-infected participants had significantly higher ECV fraction than controls (0.30±0.03 vs 0.26±0.03; p=0.0036) regardless of myocardial damage markers, hypertension, smoking pack-years, or fibrosis stage. The results suggest early extrahepatic myocardial tissue inflammation/fibrosis may occur before overt liver fibrosis, supporting early HCV treatment to reduce systemic complications.

D’Amore A, Sirajuddin A, George N et al. · Journal of viral hepatitis · (2026) · View on PubMed ↗

Pathological Q Waves in a Young Patient Without Ischemic Heart Disease.

This JACC Case Reports report described an 18-year-old asymptomatic man with pathological septal Q waves on electrocardiography but no ischemic heart disease on initial evaluation. Multimodality cardiac imaging—particularly cardiac MRI for tissue characterization—was emphasized as central to differential diagnosis and risk stratification for atypical ECG findings. The case highlights the clinical importance of cardiac MRI when pathological Q waves occur without an obvious ischemic cause.

Figueroa-Galván FS, Alanís-Naranjo JM, González-Najera MF et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗

Evaluation of new vectorcardiography algorithms for identifying left ventricular hypertrophy and impaired systolic function.

This prospective study evaluated new vectorcardiography (VCG) algorithms for diagnosing left ventricular hypertrophy (LVH) and impaired systolic function in comparison with cardiac magnetic resonance imaging (CMR). The key finding was that VCG can provide diagnostic performance for LVH and systolic impairment that is benchmarked against CMR, addressing the limited sensitivity of routine 12-lead ECG for subtle structural disease. The clinical significance is that optimized, scalable VCG could enable earlier screening for structural heart abnormalities using a noninvasive electrical technique.

Salatzki J, Schwarz AK, Wolfsteller S et al. · Journal of electrocardiology · (2026) · View on PubMed ↗ · Free PDF ↗

Incremental Prognostic Value of Pericardial Adipose Tissue Radiomic Phenotype Based on Cardiac MRI in Patients With End-Stage Renal Disease.

This retrospective multi-center study assessed whether pericardial adipose tissue (PEAT) radiomic features from cardiac MRI improve prediction of major adverse cardiac events (MACE) in 248 end-stage renal disease (ESRD) patients. The key finding is that a PEAT radiomic phenotype provides incremental prognostic value beyond conventional PEAT volume for MACE risk stratification, with development/validation cohorts across three centers. Clinically, this supports using cardiac MRI radiomics to better identify high-risk ESRD patients for targeted prevention.

Zhang TY, Liu Y, Chen SZ et al. · Journal of magnetic resonance imaging : JMRI · (2026) · View on PubMed ↗

Atorvastatin and left ventricular strain during anthracycline-based chemotherapy.

This randomized STOP-CA trial analysis tested whether atorvastatin protects against anthracycline-induced impairment of left ventricular deformation in lymphoma patients receiving anthracycline-based chemotherapy. The key finding is that cardiac MRI feature tracking (FT) measurements of global longitudinal strain (GLS) and global circumferential strain (GCS) show attenuation of declines in the atorvastatin group versus placebo over 12 months. This is significant because it provides evidence for a cardioprotective strategy to reduce subclinical anthracycline cardiotoxicity using MRI-derived strain biomarkers.

Juhasz V, Quinaglia T, Drobni ZD et al. · International journal of cardiology · (2026) · 1 citations · View on PubMed ↗ · Free PDF ↗

Correlation across modalities and clinical phenotypes between left Ventricular global longitudinal strain by echocardiography and cardiac magnetic resonance.

This systematic review and meta-analysis compared left ventricular global longitudinal strain (LV-GLS) measured by speckle-tracking echocardiography (STE) versus cardiac magnetic resonance feature tracking (CMR-FT) across cohorts of healthy participants and patients with cardiovascular disease. The pooled analysis quantified the strength of cross-modal correlation (patient-level Pearson r) and assessed consistency via subgroup analyses for healthy versus cardiovascular disease cohorts. Clinically, the findings clarify how reliably STE and CMR-FT can be used interchangeably for LV-GLS across different phenotypes.

Pascalis L, Fazzini L, Pugliesi GM et al. · Current problems in cardiology · (2026) · View on PubMed ↗

Systemic inflammation, myocardial fibrosis, and subclinical cardiovascular disease in people living with HIV.

In a cross-sectional pilot study of matched Providence VA veterans with and without HIV, the authors examined relationships among systemic inflammation, myocardial fibrosis, and subclinical cardiovascular disease using questionnaires, stress testing, echocardiography, cardiac MRI, coronary calcium scoring, and inflammatory blood biomarkers. The study linked HIV-associated systemic inflammation with myocardial fibrosis and markers of subclinical cardiovascular disease. These results support a mechanistic role for chronic inflammation in accelerated cardiovascular aging in people living with HIV and motivate targeted imaging and biomarker-driven risk stratification.

Simkevich M, Chen YY, Parent M et al. · American heart journal · (2026) · View on PubMed ↗ · Free PDF ↗

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Cardiac Imaging AI, Automation & Federated/ML Methods

Transforming Cardiac Imaging With Artificial Intelligence: Automation, Precision, and Clinical Integration in Echocardiography and Magnetic Resonance Imaging.

This narrative review synthesized evidence from 22 studies (2020–2026) on how artificial intelligence is transforming cardiac imaging workflows in echocardiography and cardiac magnetic resonance (CMR). The key finding was that AI enables automation of image acquisition, segmentation, and quantitative measures (e.g., ejection fraction and global longitudinal strain) with accuracy comparable to expert readers while reducing analysis time and interobserver variability. This is significant for clinical integration because it outlines practical pathways for deploying AI to improve efficiency and consistency in routine cardiac imaging.

Choker AH · Echocardiography (Mount Kisco, N.Y.) · (2026) · View on PubMed ↗

Leveraging natural language processing artificial intelligence for automated data extraction of ejection fraction and strain from cardiovascular imaging reports.

This retrospective observational study applied natural language processing (NLP) to extract ejection fraction (EF) and related cardiac imaging parameters from free-text cardiovascular imaging reports across modalities (echocardiography, nuclear cardiology, and CMR) in more than 4000 cancer survivors at a large academic medical center over 2000–2020. The key finding was that NLP was feasible for automated, longitudinal extraction of EF and related measurements from multi-modality imaging reports. This supports scalable, real-world data harmonization for cardio-oncology research using routinely collected imaging documentation.

Brown SA, BagheriMohamadiPour M, Sparapani R et al. · American heart journal plus : cardiology research and practice · (2026) · View on PubMed ↗ · Free PDF ↗

FedSemiDG: Domain generalized federated semi-supervised medical image segmentation.

The study investigated domain generalized federated semi-supervised learning (FedSemiDG) for medical image segmentation across multiple centers, focusing on how domain shift affects federated aggregation when labeled data are scarce. The key finding is that explicitly addressing domain shift improves the effectiveness of using unlabeled data and yields better performance on unseen domains than standard federated semi-supervised aggregation. This is significant because it advances federated learning for real-world multi-center medical imaging where patient populations and scanners differ, improving generalization without sharing raw data.

Deng Z, Xu Z, Isshiki T et al. · Medical image analysis · (2026) · View on PubMed ↗

Large Language Models for Cardiac MRI Diagnosis Based on Standardized Text Descriptions.

This retrospective study evaluated large language models (LLMs) for cardiac MRI diagnosis using standardized text descriptions in a cohort including hypertrophic cardiomyopathy, dilated cardiomyopathy, hypertensive heart disease, ischemic cardiomyopathy, constrictive pericarditis, cardiac amyloidosis, myocarditis, and normal controls. The key finding is that LLM-based interpretation of standardized descriptions can support cardiac MRI diagnostic classification in less experienced centers. Clinically, this suggests a scalable decision-support approach that reduces expertise barriers by translating structured imaging findings into model-ready text.

Zhang H, Zhou J, Zhang C et al. · Journal of magnetic resonance imaging : JMRI · (2026) · View on PubMed ↗

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Cardiac MRI/CT Technical Advances & Reconstruction/Low-Field Imaging

A Comparison of Tissue Property Values Estimated Using Conventional Cardiac MRF and MT-Cardiac MRF.

The study compared conventional cardiac magnetic resonance fingerprinting (cMRF) versus magnetization-transfer (MT)–modeled MT-cMRF for estimating cardiac tissue parameters (T1/T1f, T2/T2f, and bound pool fraction [BPF]) in 14 healthy human subjects, using simulations and phantom experiments to validate accuracy. MT-cMRF reconstruction that explicitly modeled MT processes produced more reliable separation and quantification of the free-water and bound-pool components (T1f, T2f, and BPF) than a conventional dictionary that ignored MT. This supports improved quantitative cMRF for characterizing myocardial microstructure and could enhance downstream clinical interpretation of T1/T2-based tissue phenotyping.

Kaplan S, Liu Z, Hamilton J et al. · Magnetic resonance in medicine · (2026) · View on PubMed ↗ · Free PDF ↗

The importance of spatial resolution in detecting chronic myocardial iron remnants following hemorrhagic myocardial infarction with T2* MRI.

This study investigated how spatial resolution affects detection of chronic myocardial iron remnants after hemorrhagic myocardial infarction (hMI) using T2* cardiac MRI, combining digital phantom simulations and ex vivo swine hearts (n=10) with 8-week hMI. Across voxel sizes (0.4–2.0 mm in-plane and 2–8 mm slice thickness) and varying signal-to-noise ratio (SNR), the authors assessed detection performance of iron deposits and quantified how resolution changes sensitivity. The findings provide practical imaging guidance for optimizing T2* MRI acquisition to improve identification of chronic iron from hMI, which is clinically relevant for prognosis.

Zhang X, Yang HJ, Dharmakumar R · Biomedical physics & engineering express · (2026) · View on PubMed ↗ · Free PDF ↗

Computational modeling of left ventricular flow using PC-CMR-derived four-dimensional wall motion.

This computational modeling study proposed individualized left ventricular (LV) flow simulations by integrating PC-CMR-derived four-dimensional wall motion with additional MRI modalities to drive moving-geometry models for computational fluid dynamics (CFD). The goal was to create feasible, imaging-driven LV hemodynamic characterization without fully coupled fluid–solid modeling, which is difficult due to complex myocardial passive-active behavior. Such PC-CMR/CFD hybrid models could enable more personalized assessment of LV hemodynamics for cardiac disease research and potentially clinical decision support.

Peighambari SB, Mukherjee T, Mendiola EA et al. · International journal of engineering science · (2026) · View on PubMed ↗

In vivo evidence of blood flow slippage: failure of the no-slip boundary condition assumption.

This in vivo study tested the no-slip boundary condition assumption in cardiovascular fluid dynamics by imaging seven healthy adult volunteers with 4D flow CMR of the descending thoracic aorta and performing Navier–Stokes data assimilation to estimate near-wall tangential velocities and wall shear stress. The results showed evidence of blood flow slippage, with tangential wall velocities estimated at approximately 30–80% of the measured values (as reported in the abstract). These findings challenge a foundational modeling assumption and may improve the physiological accuracy of cardiovascular flow simulations used in research and potentially in clinical biomechanics.

Jarolímová A, Hron J, Tůma K et al. · American journal of physiology. Heart and circulatory physiology · (2026) · View on PubMed ↗

Diagnosis of cardiac pathology on acute electrocardiographic-gated thoracic computed tomography: guidance for the general radiologist.

This article provided guidance for general radiologists on diagnosing cardiac pathology using acute electrocardiographic-gated thoracic computed tomography (CT) angiography. It emphasizes that while acute aortic syndrome is uncommon, the same gated CT datasets can reveal other potentially life-threatening cardiac causes of acute presentation (including coronary atherosclerotic disease and related complications) that are often overlooked. The clinical significance is improved diagnostic accuracy and reduced missed diagnoses by training radiologists to systematically evaluate cardiac pathology on gated thoracic CT.

Manghat NE, Greco F, Harries I et al. · Clinical radiology · (2026) · View on PubMed ↗

Optimizing Cine Cardiac MRI: Technical Advances and Clinical Applications.

This review studied technical advances for optimizing cine cardiac MRI, focusing on pulse-sequence parameters (TR, TE, flip angle, bandwidth) to improve signal-to-noise ratio and temporal resolution. It found that while balanced steady-state free precession (bSSFP) is standard, performance can be limited by off-resonance effects, SAR constraints, and susceptibility artifacts—especially at ≥3T scanners. The scientific significance is that these optimization strategies can improve the reliability of cine MRI for clinical cardiac function assessment.

Dehghani S, Rajabi A, Rahmati A et al. · Journal of magnetic resonance imaging : JMRI · (2026) · View on PubMed ↗

Improved Myocardial Sodium Quantification at 7 T Using Interleaved 23Na/1H pTx MRI With Motion and Anatomy-Based B1 Correction.

This 7T MRI technical study aimed to improve myocardial 23Na quantification accuracy and repeatability by using interleaved 23Na/1H pTx MRI with motion correction and anatomy-based B1 bias field correction. The key finding is that combining nnUNet-based myocardium/blood-pool segmentation from 1H data with retrospective respiratory/cardiac motion correction and a novel anatomy-based B1 correction improves the reliability of myocardial sodium measurements. This is significant because more accurate 23Na quantification can strengthen cardiac metabolic imaging and biomarker studies at ultra-high field.

Ruck L, Egger N, Zobler B et al. · Magnetic resonance in medicine · (2026) · View on PubMed ↗ · Free PDF ↗

Enhanced 2D Spiral Cine DENSE MRI Using Low-Rank Denoising for Improved Apparent Signal-to-Noise Ratio, Spatial Resolution, Efficiency, Accuracy, and Accessibility.

The study developed a low-rank denoising method for displacement encoding with stimulated echoes (DENSE) MRI using spiral cine acquisitions at 0.55 T, evaluated in 36 subjects (16 healthy, 20 with heart disease) with additional high-resolution scans in 10 healthy volunteers. Low-rank denoising improved apparent signal-to-noise ratio, spatial resolution (from 2.8×2.8 mm2 to 1.2×1.2 mm2 in the high-resolution subset), efficiency, and accuracy while maintaining feasibility at lower field strength. This advances more accessible, higher-quality cardiac DENSE MRI for quantifying myocardial displacement without requiring higher-field scanners.

Shih SF, Wu Y, Li S et al. · Magnetic resonance in medicine · (2026) · View on PubMed ↗ · Free PDF ↗

Feasibility of Implicit Neural Representation Learned Motion Compensation for 3D Stack-of-Spirals Free-Breathing Cardiac Quantitative Susceptibility Mapping.

The study assessed the feasibility of a free-breathing 3D stack-of-spirals quantitative susceptibility mapping (QSM) method that uses implicit neural representations (INR) for motion compensation to estimate differential blood oxygenation (ΔSO2) noninvasively. By combining retrospective self-gated stack-of-spirals multi-echo gradient-echo acquisition with INR-based motion compensation, the approach aimed to improve robustness and reduce acquisition time compared with prospective navigator-gated 3D cartesian QSM. If validated, this could provide a practical noninvasive alternative to right-heart catheterization for monitoring cardiac oxygenation differences.

Li J, Deng A, Li C et al. · Magnetic resonance in medicine · (2026) · View on PubMed ↗

FlowVN Trained on a Single Dataset Enables Rapid Reconstruction of Highly Accelerated 4D Flow MRI Across Multiple Sites.

This study evaluated FlowVN, a deep variational network trained on a single fully sampled 4D flow MRI dataset from one site, for reconstructing heavily undersampled 4D flow MRI across multiple sites. FlowVN was tested on retrospective undersampled data (acceleration R=6–22) from both the training site and another site, as well as prospectively undersampled data (R≈12.4–13.8) including healthy volunteers and patients with aortic stenosis. The results indicate that a single-dataset-trained model can enable rapid, highly accelerated 4D flow MRI reconstruction with maintained quantitative performance across sites and patient populations.

Qazi SA, Bianchessi T, Viola F et al. · Magnetic resonance in medicine · (2026) · 1 citations · View on PubMed ↗ · Free PDF ↗

The imaging spectrum of myocardial infarction and its associated complications: a contemporary pictorial review of computed tomography and magnetic resonance imaging.

This contemporary pictorial review summarized the imaging spectrum of myocardial infarction (MI) and its complications using cardiac computed tomography (CCT) and cardiac magnetic resonance (CMR). It highlighted how CCT and CMR provide complementary information spanning coronary anatomy to myocardial tissue characterization and functional assessment, including CMR-based multiparametric evaluation of edema and infarct-related findings. The review is clinically significant for guiding appropriate selection and interpretation of CT/CMR techniques across acute and post-acute MI scenarios.

Zhang Y, Ko SM · Diagnostic and interventional radiology (Ankara, Turkey) · (2026) · View on PubMed ↗ · Free PDF ↗

Reproducibility of cardiac volumetric parameters derived from fully automatically prescribed image planes: a direct comparison to manual planning at 1.5-T and 3-T MRI.

This prospective single-center study compared reproducibility of cardiac volumetric parameters derived from fully automatically prescribed image planes versus manual planning at both 1.5 T and 3 T in 52 healthy volunteers. Automated planning produced volumetric measurements with reproducibility comparable to manual planning across the two field strengths and scan intervals. This supports scalable, less time-consuming automated CMR plane prescription for consistent longitudinal and multicenter volumetric assessment.

Deyerberg KK, Meinel FG, Watzke LM et al. · European radiology · (2026) · View on PubMed ↗ · Free PDF ↗

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Cardiac Tumors & Rare Masses (e.g., Lymphangioma, Metastases)

A case of cardiac lymphangioma: diagnosis suggested by cardiac CT and MRI and successful conservative management.

This case report described a 78-year-old woman with cardiac lymphangioma diagnosed using multimodality imaging, where cardiac CT identified a lobulated non-enhancing mass along the right coronary artery and cardiac MRI showed a multilocular cystic lesion with high T2 signal. The key finding was that imaging features suggested cardiac lymphangioma and the patient was successfully managed conservatively without standardized surgery-based protocols. Scientifically and clinically, it highlights the diagnostic value of CT/CMR pattern recognition for rare cardiac tumors and supports noninvasive management when appropriate.

Kurosaka E, Matsuda J, Yanagiya N et al. · Journal of cardiology cases · (2026) · View on PubMed ↗

Imaging of Myocardial Carcinoid Metastasis.

This case series studied two patients with metastatic neuroendocrine tumors (NETs) presenting with isolated myocardial metastases, using Gallium-68 DOTATATE PET/CT and cardiac magnetic resonance (CMR) alongside transthoracic echocardiography. Cardiac metastases were initially detected on Gallium-68 DOTATATE PET/CT and further characterized by CMR, while echocardiography had limited sensitivity for identifying myocardial involvement. The report highlights multimodality imaging as clinically significant for recognizing otherwise under-diagnosed cardiac NET metastases and guiding management when echocardiography is unrevealing.

Ranganath S, Ynalvez L, Ryoo Ali HJ et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗

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Cardiac Surgery/Interventions & Perioperative Imaging/Optimization

Cardiac Imaging Predictors of Ventricular Recovery in Pediatric Patients Undergoing Aortic Valve Intervention for Regurgitation.

This retrospective study investigated which preoperative echocardiography and cardiac MRI parameters predict postoperative left ventricular (LV) recovery in pediatric and young adult patients (<30 years) with moderate-to-severe chronic aortic regurgitation undergoing aortic valve surgery. The key finding was that specific baseline imaging markers from echocardiography and CMR were associated with the degree of LV reverse remodeling/functional recovery after intervention. Clinically, it helps refine timing and patient selection for aortic valve intervention in younger patients by identifying imaging predictors rather than relying solely on adult-derived surgical thresholds.

Flerlage EK, Huma LC, Gandhi R et al. · Pediatric cardiology · (2026) · View on PubMed ↗

One Anatomy, Multiple Valve Choices: Interobserver Agreement in Selecting Transcatheter Pulmonary Valve.

This study evaluated interobserver agreement in selecting transcatheter pulmonary valve (TPVR) device type, size, and position using 3D patient-specific anatomies reconstructed from cardiac magnetic resonance (CMR) images. Six experienced observers independently assessed 60 pediatric and adult anatomies, and the key finding was the degree of variability (interobserver agreement) in TPVR planning decisions across valve types (self-expanding, balloon-expandable, and surgical approach) and anatomical positioning. The clinical significance is that quantifying agreement can guide standardization of imaging-based TPVR selection and reduce planning variability.

Pérez-Cualtán CE, Cabrales J, Garay F et al. · Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions · (2026) · View on PubMed ↗ · Free PDF ↗

Cardiac magnetic resonance imaging assessment of Del Nido versus cold blood cardioplegia in patients with low ejection fraction undergoing combined coronary artery bypass graft and mitral valve replacement: Early outcomes.

This single-center prospective study used cardiac magnetic resonance (CMR) to compare early myocardial functional recovery after Del Nido cardioplegia (DNC) versus conventional cold blood cardioplegia (CBC) in patients with low ejection fraction undergoing concomitant CABG and mitral valve replacement (MVR). The key finding was the early CMR-based assessment of differences in myocardial functional recovery between the two cardioplegia strategies in 42 patients with LVEF <45%. Scientifically and clinically, the results inform myocardial protection choices in high-risk cardiac surgery patients with reduced LVEF.

Gode S, Polat M, Eroğlu Polat A et al. · Turk gogus kalp damar cerrahisi dergisi · (2026) · View on PubMed ↗ · Free PDF ↗

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Cardiovascular Risk Prediction & Decision Support (EHR/ML/Polygenic Scores)

Prediction of hypertension and restenosis under guideline-directed management in aortic coarctation: development and validation of machine-learning models.

This study developed and validated machine-learning models to predict hypertension and restenosis in individuals with aortic coarctation (CoA) under guideline-directed management using routinely collected electronic health records plus cardiovascular magnetic resonance (CMR) and follow-up data from 160 patients (218 visits) in Berlin, Germany. The key finding was that ML models (e.g., CatBoost, XGBoost, random forest, support vector classifiers, neural networks) could stratify risk of future hypertension and restenosis despite recurrence occurring in up to one-third of patients over time. Clinically, such models could enable more personalized surveillance and management strategies for long-term outcomes after CoA treatment.

Fierley L, Versnjak J, Gabel G et al. · EClinicalMedicine · (2026) · View on PubMed ↗ · Free PDF ↗

Variability in Cardiac Stress Test Interpretation: Agreement Between Enrollment Sites and Core Laboratories in the Global ISCHEMIA Trial.

This ISCHEMIA trial analysis examined variability in interpretation of myocardial ischemia on cardiac stress tests between enrollment sites and core laboratories in patients with chronic coronary disease and moderate-to-severe ischemia. The key finding was that stress-test reading showed measurable disagreement/variation across sites versus core laboratories, highlighting inconsistency in ischemia interpretation. This is significant because it affects risk stratification and trial endpoints, and it supports the need for harmonized training, protocols, or adjudication in multicenter stress-testing workflows.

O’Keefe E, Sperry BW, Jones PG et al. · Circulation. Population health and outcomes · (2026) · View on PubMed ↗

Polygenic Risk Identifies Older Adults Who May Benefit From Aspirin for the Primary Prevention of Ischemic Stroke.

This post hoc analysis studied whether an integrative polygenic score (iPGS) can identify older adults who may benefit from low-dose aspirin for primary prevention of ischemic stroke within the ASPREE randomized trial. In 12,031 genotyped European-ancestry participants aged >70 years without prior cardiovascular disease, the iPGS was derived from >1.2 million variants and evaluated to stratify aspirin net benefit. The scientific significance is that polygenic risk stratification could refine aspirin use in older adults by targeting those most likely to gain benefit while minimizing bleeding risk.

Yu C, Hussain SM, Fransquet PD et al. · Stroke · (2026) · 1 citations · View on PubMed ↗

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Non-cardiac/Other Clinical Research (e.g., oncology, mental health, suicide, infectious clones)

The burden of ovarian cancer attributable to occupational asbestos exposure in Asia from 1990 to 2021: an analysis of the global burden of disease study 2021.

This Global Burden of Disease 2021 analysis quantified ovarian cancer (OC) deaths and disability-adjusted life years (DALYs) attributable to occupational asbestos exposure across Asian countries from 1990 to 2021. The key finding was that OC burden attributable to occupational asbestos exposure is measurable across Asia and shows distinct temporal trends over the 1990–2021 period. Scientifically and clinically, the results strengthen the evidence base for occupational exposure prevention and for targeting surveillance and risk-reduction efforts in high-asbestos-use settings.

Yu Y, Zhang W, Deng T et al. · Tropical medicine and health · (2026) · View on PubMed ↗

Learning curves in Versius-assisted colorectal surgery: a risk-adjusted CUSUM analysis from a single center.

This retrospective single-center study evaluated procedure- and operator-specific learning curves for Versius-assisted colorectal cancer surgery in consecutive adults undergoing right hemicolectomy, sigmoid resection, or anterior rectal resection between December 2022 and August 2025. Using risk-adjusted CUSUM (RA-CUSUM) of skin-to-skin operative time, it identified learning-curve patterns that account for patient- and procedure-specific risk. The results are significant for optimizing training, credentialing, and perioperative planning when adopting the Versius robotic platform.

Sachańbiński T, Miodoński M, Kropieniewicz J · International journal of colorectal disease · (2026) · View on PubMed ↗ · Free PDF ↗

Translation, cross-cultural adaptation, and psychometric evaluation of the Arabic version of the University of Wisconsin running injury and recovery index: a reliability and validity study.

This study translated and cross-culturally adapted the University of Wisconsin Running Injury and Recovery Index (UWRI) into Arabic (UWRI-Ar) and evaluated its psychometric properties in 83 Arabic-speaking recreational/competitive runners aged 18–45 with running-related injury, with test-retest in 49 participants over 2–5 days. The UWRI-Ar demonstrated acceptable reliability and validity for measuring running injury and recovery outcomes using online survey administration across multiple physical therapy clinics. This provides a clinically usable Arabic patient-reported outcome measure to support assessment and research in Arabic-speaking runners with running-related injury.

Aljohani MMA, Alshehri YS, Shuwayhi AM et al. · BMC sports science, medicine & rehabilitation · (2026) · View on PubMed ↗ · Free PDF ↗

Strategies for resilient climate in smart cities mediated by Nash equilibrium and autonomous decision-makers.

This paper studied a decision-making framework for resilient climate in smart cities by integrating Nash equilibrium, autonomous multi-agent systems, and machine learning to model city-level policy choices for pollution and climate warming risk management. The key finding was that autonomous decision-makers using Nash-equilibrium-based strategy selection can generate tailored mitigation policies under global warming pressures. Scientifically, it provides a computational approach for optimizing city-specific greenhouse-gas and risk-management strategies in smart-city settings.

Latha CM, Alvarado-Mentado M · Journal of environmental management · (2026) · View on PubMed ↗

A Global Consensus Conference on Surgical Management of Primary Uterovaginal Prolapse and Lower Urinary Tract Dysfunction: Combining Evidence with Expert Opinion.

This global consensus conference studied best-practice surgical management for primary uterovaginal pelvic organ prolapse (U-POP) and associated lower urinary tract dysfunction by combining systematic review evidence with expert opinion across geographically diverse committees. The key output was a structured set of recommendations and identified unanswered research questions derived from MEDLINE, Embase, and ClinicalTrials.gov searches (2000–Dec 2025) and committee-specific pragmatic questions. This is significant because it standardizes guidance for controversial aspects of U-POP surgery and improves the quality of future research planning and systematic reviews.

Gupta A, Grimes CL, Badlani G et al. · International urogynecology journal · (2026) · View on PubMed ↗ · Free PDF ↗

Zanubrutinib combined with R-CHOP in previously untreated diffuse large B-cell lymphoma with specific gene alteration: a phase II study.

This phase II trial evaluated zanubrutinib (a BTK inhibitor) combined with R-CHOP as first-line therapy in adults (18–75 years) with diffuse large B-cell lymphoma (DLBCL) carrying high-risk genomic alterations including MYD88, CD79B, NOTCH1, TP53 mutations and/or MYC rearrangements. The key finding was the rationale-driven assessment of whether adding zanubrutinib improves outcomes in genomically defined high-risk DLBCL compared with historical expectations for R-CHOP alone. If effective, this would support a genotype-guided frontline strategy targeting aberrant B-cell receptor (BCR) signaling in BTK-sensitive molecular subgroups.

Zhang Q, Jiang S, Wei R et al. · Blood cancer journal · (2026) · View on PubMed ↗ · Free PDF ↗

Updated patient-reported outcomes and the effect of disease progression on health-related quality of life in the PRIMA/ENGOT-OV26/GOG-3012 trial of niraparib first-line maintenance therapy in patients with newly diagnosed advanced ovarian cancer.

This analysis of the PRIMA/ENGOT-OV26/GOG-3012 randomized trial assessed updated patient-reported health-related quality of life (HRQOL) and the impact of disease progression in patients with newly diagnosed advanced ovarian cancer receiving niraparib first-line maintenance versus placebo. The key finding was that longitudinal HRQOL was measured using EORTC QLQ-C30 and QLQ-OV28, FOSI, and EQ-5D-5L (including EQ-VAS), and that disease progression adversely affected HRQOL trajectories. Scientifically and clinically, these results help contextualize the tolerability and patient-centered benefits/harms of niraparib maintenance over time.

Shahin MS, Lorusso D, Backes FJ et al. · Gynecologic oncology · (2026) · View on PubMed ↗

Cardiac Safety Outcomes in Delandistrogene Moxeparvovec Clinical Trials for Duchenne Muscular Dystrophy with Up to 5 Years of Follow-up.

This pooled clinical-trial safety assessment evaluated cardiac safety outcomes of delandistrogene moxeparvovec, a gene transfer therapy delivering a functional dystrophin gene product, in patients with Duchenne muscular dystrophy (DMD) with up to 5 years of follow-up. Across trials (101, 102, ENDEAVOR, EMBARK) that excluded baseline LVEF <40%, the key finding was the characterization of adverse events and serial cardiac echocardiography findings (including regular troponin I monitoring) to define the therapy’s cardiac safety profile over time. Clinically, these data inform long-term monitoring and risk management for DMD patients receiving dystrophin gene therapy.

Veerapandiyan A, Bourke J, Soslow JH et al. · Cardiology and therapy · (2026) · View on PubMed ↗ · Free PDF ↗

Use of advanced cardiovascular imaging in rheumatic immune-mediated inflammatory diseases.

This retrospective, multi-center UK quality-improvement study assessed real-world use of advanced cardiovascular imaging—cardiac magnetic resonance (CMR), CT coronary angiography (CTCA), and positron emission tomography (PET)—in adults with less common/rare rheumatic immune-mediated inflammatory diseases (IMIDs). The key finding was substantial variation in imaging practice across systemic lupus erythematosus, systemic sclerosis, inflammatory myopathy, vasculitis, and primary Sjögren’s disease, indicating non-uniform adoption of advanced imaging. The significance is that mapping current practice can identify evidence gaps and inform future clinical guidelines and study designs for cardiovascular assessment in these IMIDs.

Gumber L, Meghji MA, Kakkar V et al. · Rheumatology (Oxford, England) · (2026) · View on PubMed ↗ · Free PDF ↗

Atypical Case of Takayasu Aortitis Presenting as Embolic Stroke With Concomitant Massive Thoracic Artery Aneurysm.

This case report described a 44-year-old woman presenting with embolic stroke and a concomitant massive thoracic aortic aneurysm in the setting of atypical Takayasu aortitis. She underwent open surgical repair with placement of a Dacron graft, and surgical pathology showed granulomatous inflammation consistent with an autoimmune or infectious etiology. The report highlights the need to consider large-vessel vasculitis such as Takayasu aortitis in patients with embolic stroke plus thoracic aortic aneurysm, where timely surgical and diagnostic evaluation may be critical.

Henson JC, Myers JH, Cummins M et al. · Clinical case reports · (2026) · View on PubMed ↗ · Free PDF ↗

CAR-T Cell Therapy Versus Salvage Chemotherapy in Relapsed/Refractory DLBCL: A Systematic Review and Meta-Analysis Integrating Radiologic, Laboratory, and Histopathologic Correlates.

This systematic review and meta-analysis compared chimeric antigen receptor T-cell (CAR-T) therapy versus salvage chemotherapy in adult patients with relapsed/refractory diffuse large B-cell lymphoma (R/R DLBCL), integrating radiologic, laboratory, and histopathologic correlates. Using PRISMA 2020 and MOOSE-guided inclusion of randomized trials and high-quality comparative cohort studies, the analysis synthesized comparative effectiveness across relevant clinical subgroups, including high-risk molecular features and primary refractory disease. The results aim to clarify when CAR-T provides superior outcomes to salvage chemotherapy and to inform treatment selection in R/R DLBCL.

Elsayed FM, Baban J, Elkholy HY et al. · La Clinica terapeutica · (2026) · View on PubMed ↗

Autologous Stem Cell Transplantation Of HIV-Positive Plasmablastic Lymphoma - Case Series.

This case series described autologous stem cell transplantation (ASCT) outcomes in HIV-positive patients with plasmablastic lymphoma (PBL), focusing on safety and efficacy when used as consolidation at first complete response (CR1) after initial therapy. The report addresses the clinical challenge that historically limited aggressive treatment in HIV due to opportunistic infection risk, noting that highly active antiretroviral therapy (HAART) has enabled more intensive regimens including ASCT. The series contributes real-world evidence supporting feasibility of ASCT consolidation in selected HIV-associated PBL patients.

Giri Raja Pandiyan VM, Perumal Kalaiyarasi J, Govindarajan DD et al. · Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion · (2026) · View on PubMed ↗

Septic cardiomyopathy: Fact or fiction?

This review article examined whether septic cardiomyopathy (SCM) is a distinct clinical entity in patients with sepsis, focusing on the inflammatory, metabolic, endothelial, and microvascular mechanisms that drive acute myocardial dysfunction. It concludes that SCM is often reversible within days but remains poorly defined because there are no standardized diagnostic criteria and because its presentation overlaps with other acute cardiomyopathies such as Takotsubo cardiomyopathy and myocarditis. Clarifying SCM’s diagnostic framework is scientifically important to enable more accurate recognition and management of sepsis-associated cardiac dysfunction.

Naimi A, Rodriguez M, Qadeer YK et al. · American heart journal plus : cardiology research and practice · (2026) · View on PubMed ↗ · Free PDF ↗

CTLA4-Ig + Anti-IL-6/IL-6R Treatment Results in Long-term Allograft Survival and Function in Highly HLA-sensitized Patients.

This clinical study evaluated long-term transplant outcomes in highly HLA-sensitized patients who were treated with a combination regimen of CTLA4-Ig plus anti–IL-6/IL-6 receptor therapy, particularly for those at high risk of cell-mediated and antibody-mediated rejection. The key finding was that this combined approach achieved long-term allograft survival and maintained graft function in this difficult-to-treat population. The regimen may offer a CNI-sparing option for highly HLA-sensitized transplant recipients, potentially reducing rejection risk while addressing CNI neuro/nephrotoxicity.

Jordan SC, Chandran S, Ammerman N et al. · Transplantation direct · (2026) · View on PubMed ↗ · Free PDF ↗

Continuous Glucose Monitoring and Mortality Risk Among U.S. Veterans Receiving Dialysis With Diabetes.

This cohort study assessed whether continuous glucose monitoring (CGM) use is associated with mortality among U.S. veterans with diabetes receiving dialysis, using linked national Veterans Affairs, U.S. Renal Data System, and Medicare data. The key finding (as framed by the study objective and design) was the evaluation of survival differences between CGM users versus non-CGM users in this high-risk population. If CGM is associated with improved survival, it would support broader CGM implementation in dialysis patients with diabetes to better characterize dysglycemia and inform outcomes-focused care.

Narasaki Y, Kalantar-Zadeh K, Zisman-Ilani Y et al. · Diabetes care · (2026) · View on PubMed ↗ · Free PDF ↗

Sustainable Low-Field Cardiovascular Magnetic Resonance in Changing Healthcare Systems-An Update.

This narrative update reviewed the feasibility and performance of low-field (LF) cardiovascular magnetic resonance (CMR), especially around 0.55 Tesla, in settings where high-field CMR adoption is limited by cost and infrastructure barriers. It highlights that optimized hardware (e.g., gradient coils and radiofrequency systems) and AI-driven reconstruction can maintain strong diagnostic performance despite lower signal-to-noise ratios. The review’s significance is that LF CMR could expand access to gold-standard cardiac imaging in low- and middle-income countries and other resource-constrained healthcare systems.

Umair M, Marey A, Murali S et al. · NMR in biomedicine · (2026) · View on PubMed ↗ · Free PDF ↗

Intentional self-harm mortality among 15-24 year olds in Asian American subgroups, 2005-2022: a population-based incidence study.

This population-based incidence study examined intentional self-harm mortality among U.S. youth aged 15–24 years across six Asian American subgroups (Asian Indian, Chinese, Filipino, Japanese, Korean, Vietnamese) from 2005–2022 using National Center for Health Statistics mortality data. The key finding was that suicide mortality rates differed by Asian American subgroup, with subgroup-specific annualized mortality rates and rate ratios calculated against comparison groups (non-Hispanic White and Asian youth). The clinical/public health significance is improved surveillance granularity to better target prevention resources for youth suicide risk within specific Asian American communities.

Uy LA, Chang E, Desai S et al. · Lancet regional health. Americas · (2026) · View on PubMed ↗ · Free PDF ↗

Fetal MRI for cardiopulmonary anomalies: what the pediatric cardiologist and surgeon need to know.

This review studied how fetal cardiac magnetic resonance imaging (CMR) can be integrated into prenatal evaluation of cardiopulmonary anomalies alongside expert fetal echocardiography. It found that fetal CMR provides high-resolution, multiplanar imaging with superior soft-tissue contrast and a wide field of view, enabling diagnostic or prognostic information when echocardiography is limited by technical/physiologic factors. The clinical significance is an evidence-based framework to guide counseling, delivery planning, and postnatal management for complex fetal cardiopulmonary disease.

Dadoun SE, Mokha S, Kooraki S et al. · Current opinion in cardiology · (2026) · View on PubMed ↗

Interpersonal Relationship, Academic Performance, & Life Skills: A Comparative Study of Children With and Without Emotional and Behavioral Problems.

This cross-sectional comparative study examined how emotional and behavioral problems (EBPs) relate to interpersonal relationships, academic performance, and life skills in children aged 6–14 years from West Bengal. Children with EBPs scored significantly lower on interpersonal relationships (p = .015) and life skills compared with children without EBPs, using standardized tools including the Pediatric Symptom Checklist (PSC), CIRAA, APS, and LSAS. The clinical significance is that identifying EBPs may help target interventions to improve social functioning and practical life skills alongside academic outcomes.

Kheto P, Pallerla S, Bhattacharjee K et al. · Clinical child psychology and psychiatry · (2026) · View on PubMed ↗

Construction and modification of a low-copy plasmid-based infectious clone for GI-19 genotype IBV via Red/ET recombineering: A simplified and efficient reverse genetics system for coronavirus.

This study constructed and modified a low-copy plasmid-based infectious clone for avian infectious bronchitis virus (IBV) GI-19 genotype using Red/ET recombineering to create a simplified reverse genetics system. The key finding is that integrating low-copy plasmid vectors with RecE/RecT-mediated recombination plus positive/counter-selection enables efficient genome cDNA assembly, precise genetic modification, and rapid recombinant virus screening. This is significant for coronavirus research and vaccine/variant engineering in poultry by providing a faster, more streamlined platform for generating defined IBV mutants.

Feng K, Li Y, Song C et al. · Poultry science · (2026) · View on PubMed ↗ · Free PDF ↗

Role of predelivery fetal echocardiography, cardiac magnetic resonance imaging and acute maternal hyperoxygenation in predicting urgency of neonatal balloon atrial septostomy in fetal dextro-transposition of the great arteries.

This prospective single-center cohort study evaluated whether predelivery fetal echocardiography and cardiac MRI in room air and during acute maternal hyperoxygenation (AMH) can predict neonatal hypoxia and urgent balloon atrial septostomy (BAS) within 3 hours in pregnancies with fetal dextro-transposition of the great arteries (TGA) with intact ventricular septum or small ventricular septal defect (≤4 mm). Predelivery imaging features obtained in room air and under AMH were used to identify infants at imminent risk for severe hypoxia requiring urgent BAS. The work could improve perinatal planning by using noninvasive fetal imaging to anticipate which neonates will need immediate interventional shunting.

Jaeggi E, Sun L, Saito M et al. · Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology · (2026) · View on PubMed ↗

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Generated automatically on July 04, 2026. Covers PubMed articles published June 27, 2026 – July 04, 2026. Summaries are AI-generated; always consult the original publication for clinical or research decisions.