What's New in Cardiac MRI? — July 05, 2026

AI-summarised digest of 92 PubMed articles on Cardiac MRI published in the last 7 days.

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Cardiac MRI biomarkers of fibrosis, inflammation, and tissue remodeling Cardiac MRI mapping, quantitative imaging methods, and physics Cardiac MRI/CT/PET diagnostic pathways and multimodality imaging Cardio-oncology and treatment-related cardiac effects Arrhythmias and electrophysiology risk stratification Ischemia, microvascular dysfunction, and MINOCA/CME Heart failure phenotyping, prognosis, and reverse remodeling Cardiovascular imaging in special populations (pediatrics, pregnancy, rare diseases) Valvular heart disease and transcatheter/surgical planning Transplant immunology and graft outcomes Diabetes, dysglycemia, and kidney-related cardiovascular risk Machine learning, AI, and automated imaging/decision support Standardization, reproducibility, and interobserver variability Clinical decision frameworks and guideline/consensus development Non-cardiac clinical outcomes and public health

What’s New in Cardiac MRI?

July 05, 2026 · 92 articles · 15 research themes · covering June 28, 2026 – July 05, 2026

Overview

Across this week’s set, a dominant theme is the move from “diagnose the disease” to “measure the biology.” Multiple studies use cardiac MRI tissue characterization—especially extracellular volume (ECV), late gadolinium enhancement (LGE), native T1/T2, and strain—to detect diffuse interstitial remodeling, inflammation, and fibrosis before overt clinical endpoints. Examples include HIV-associated systemic inflammation linked to myocardial fibrosis, chronic hepatitis C showing subclinical myocardial ECV elevation, and several amyloidosis cohorts where ECV/strain/LGE features improve prognostic stratification beyond traditional staging or single metrics. Even in acute settings (e.g., reperfused STEMI with microvascular obstruction, myocarditis follow-up, and sepsis-related myocardial calcification), imaging is positioned as a way to predict short- and long-term risk and to separate reversible inflammatory phenotypes from fixed damage.

A second major thread is precision risk stratification for cardiovascular events—particularly arrhythmias and ischemic syndromes that are hard to classify. Studies and reviews emphasize that conventional markers can miss key mechanisms: stress CMR mapping may be insufficient for MINOCA with normal CMR; coronary microembolization biology remains incompletely defined; and conduction-isthmus features may outperform global scar metrics for predicting VT rate. In amyloidosis and ischemic heart disease, deep learning and multi-feature CMR approaches aim to refine sudden arrhythmic death risk beyond ejection fraction alone. Parallel work in electrophysiology highlights that “absence of fibrosis” or “mild valve disease” does not always mean low risk (e.g., malignant MVP), reinforcing multimodal, mechanism-aware evaluation.

Finally, the digest reflects rapid methodological and workflow change. AI and automated pipelines (from NLP extraction of imaging measurements to AI reconstruction for low-field CMR and federated learning robust to domain shift) are increasingly used to scale imaging-derived phenotypes. At the same time, several papers stress the need for standardization—inter-site stress-test interpretation variability, cross-modality agreement for strain, and radiology guidance for extracting more from existing CT datasets. Together, these studies suggest cardiology is converging on scalable, quantitative, and standardized imaging plus decision support to enable earlier intervention and more consistent care.

Cardiac MRI biomarkers of fibrosis, inflammation, and tissue remodeling

Improving arrhythmic risk prediction using cardiac magnetic resonance within deep learning in ischemic heart disease.

This study evaluated whether late gadolinium enhancement cardiac magnetic resonance (LGE-CMR) improves sudden arrhythmic death risk prediction in ischemic heart disease (IHD) patients across two independent cohorts (Dataset 1 n=399; Dataset 2 n=424 from REVIVED-BCIS2). LGE-CMR scar burden/heterogeneity features provided incremental prognostic value beyond conventional clinical markers such as left ventricular ejection fraction. Improved CMR-based deep learning risk stratification could refine clinical selection for preventive therapies against arrhythmic events in IHD.

Sen A, Jones RE, Morgan H et al. · NPJ cardiovascular health · (2026) · View on PubMed ↗

Cardiac MRI-based strain analysis for the assessment of left atrial dysfunction in patients with atrial fibrillation.

This retrospective study assessed whether cardiac magnetic resonance feature tracking (CMR-FT) left atrial (LA) strain parameters detect early LA dysfunction in atrial fibrillation (AF) patients (n=113) compared with age- and sex-matched healthy controls (n=52). AF patients showed impaired LA functional strain metrics (εs, εe, εa) and the study identified sensitive strain indicators for early detection even when conventional static LA measures were less informative. The results are significant because CMR-FT LA strain could improve early characterization of AF-related atrial dysfunction and risk stratification.

Zhou H, Zhu D, Hao S et al. · The international journal of cardiovascular imaging · (2026) · View on PubMed ↗

Enhanced risk stratification in hypertrophic cardiomyopathy through the integration of extracellular volume fraction on cardiovascular magnetic resonance.

This cohort study evaluated whether cardiovascular magnetic resonance (CMR) extracellular volume fraction (ECV)—a marker of diffuse interstitial fibrosis—adds prognostic value beyond late gadolinium enhancement (LGE) in hypertrophic cardiomyopathy (HCM) patients (n=990). During a median 3.2-year follow-up, higher global ECV was associated with HCM-related events (sudden cardiac death, heart failure events, and HCM-related death) and improved risk stratification beyond LGE alone. The scientific significance is that integrating ECV into CMR assessment could better identify HCM patients at higher risk for adverse outcomes.

Lee HJ, Gwak SY, Lee S et al. · European heart journal. Cardiovascular Imaging · (2026) · View on PubMed ↗

Lyme Myopericarditis With Effusive-Constrictive Physiology: Serial CMR Identifies a Reversible Inflammatory Phenotype.

This case report describes a 45-year-old man with Lyme myopericarditis with effusive-constrictive physiology in whom serial cardiac magnetic resonance (CMR) was used to distinguish inflammatory from fixed constrictive physiology. The key finding is that serial CMR demonstrated a reversible inflammatory phenotype rather than irreversible constriction, aligning with management implications for inflammatory disease. Clinically, this supports using serial CMR to guide treatment decisions in complex pericardial syndromes after Lyme exposure.

Alhirtani N, Bigham G, Fabrizio C et al. · JACC. Case reports · (2026) · View on PubMed ↗

Prognosis of acute myocarditis beyond hospitalization: Results of a long-term prospective study.

This prospective single-center study followed 158 patients (mean age 32±12 years; 12.7% female) hospitalized for acute myocarditis between 2007 and 2022 using annual clinical assessment plus treadmill testing, Holter monitoring, and echocardiography. Severe complications such as cardiogenic shock or arrhythmic storm occurred in 3.6%, and the study evaluated long-term prognosis with Cox regression based on admission and follow-up findings (including left ventricular ejection fraction). These data help clinicians risk-stratify patients after acute myocarditis beyond the hospitalization period and guide long-term surveillance intensity.

de Freitas Vilela MM, Martins AM, Cazeiro D et al. · Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology · (2026) · View on PubMed ↗ · Free PDF ↗

Integrative Observational and Genetic Evidence From the UK Biobank Supports Carotid Intima-Media Thickness as a Window Into Cardiac Remodeling.

Using UK Biobank data, this integrative observational and genetic analysis studied 46,102 participants with carotid ultrasound and cardiac magnetic resonance to test whether carotid intima-media thickness (cIMT) reflects early cardiac remodeling and shares genetic architecture with cardiovascular disease. The study linked cIMT phenotypes to cardiac/aortic traits and evaluated genetic associations to support cIMT as a window into cardiac remodeling processes. This provides a mechanistic bridge between subclinical vascular disease and early cardiac structural changes that precede overt cardiovascular events.

Chong SH, Saccoh AF, van Vugt M et al. · Journal of the American Heart Association · (2026) · View on PubMed ↗ · Free PDF ↗

Myocardial Calcification as a Rare Cardiac Sequela: When Sepsis Leaves Its Mark.

This JACC Case Reports article describes a 33-year-old woman who developed myocardial calcification after severe sepsis from disseminated Streptococcus pneumoniae, with markedly elevated troponin but normal coronary angiography. Follow-up chest CT demonstrated new extensive left ventricular and papillary muscle calcifications consistent with sepsis-related myocardial calcification. The case is clinically significant because it highlights a rare but potentially persistent cardiac sequela of sepsis that may require long-term structural and functional follow-up.

El-Hamad A, Sene PM, El Mehdi El Yamani M et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗

CMR Reveals the Influence of Trigger and Classification on the Myocardial Tissue Response in Takotsubo Syndrome.

This CMR study investigated how trigger factors and the InterTAK classification—including the distinction between primary versus secondary Takotsubo syndrome (TTS)—relate to myocardial tissue responses. Using cardiovascular magnetic resonance to measure left ventricular function, myocardial edema, and myocardial injury, the authors found that myocardial tissue responses varied by trigger/classification, supporting biologic heterogeneity between primary and secondary TTS. These results are important for refining TTS phenotyping and potentially tailoring prognosis and management based on CMR-defined pathophysiology.

Gotschy A, Cammann VL, Schweiger V et al. · Circulation. Cardiovascular imaging · (2026) · View on PubMed ↗

Incremental Prognostic Value of Cardiac Magnetic Resonance Beyond Biomarker Staging in Transthyretin Cardiac Amyloidosis.

This retrospective multicenter cohort study evaluated whether adding cardiac magnetic resonance (CMR) parameters improves prognostic prediction beyond National Amyloidosis Center (NAC) serum-biomarker staging in transthyretin cardiac amyloidosis (ATTR-CA). In 266 ATTR-CA patients undergoing CMR (2007–2023), Cox regression showed that CMR variables provided incremental prognostic value over NAC stage for time to death. The findings are clinically significant because they support using CMR to better risk-stratify patients and guide evaluation for advanced heart failure therapies and emerging disease-modifying treatments.

Chiou T, Minga I, Subashchandran V et al. · European heart journal. Cardiovascular Imaging · (2026) · View on PubMed ↗

Extracellular Volume Mapping by Cardiac MRI Predicts Sudden Cardiac Death in AL Amyloidosis: A South Asian Cohort Study.

This ambispective South Asian cohort study evaluated 188 patients with biopsy-proven AL amyloidosis (with serum free light chain restriction and cardiac amyloidosis phenotype) to determine whether cardiac MRI extracellular volume (ECV) at diagnosis predicts sudden cardiac death. ECV was calculated from T1 mapping, with abnormal ECV defined as ≥25%, and among evaluable patients (n=22) those with abnormal ECV had higher risk of sudden cardiac death than those with normal ECV. The results support ECV mapping as a prognostic biomarker in AL amyloidosis, potentially improving risk stratification for sudden death.

Pattnaik SA, Ahamed H, Gutjahr G et al. · Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion · (2026) · View on PubMed ↗ · Free PDF ↗

Septic cardiomyopathy: Fact or fiction?

This narrative review studied the concept of septic cardiomyopathy (SCM) as a distinct clinical entity occurring during sepsis, contrasting it with other acute cardiomyopathies such as Takotsubo cardiomyopathy and myocarditis. It summarizes that SCM is characterized by dynamic myocardial dysfunction driven by inflammatory, metabolic, endothelial, and microvascular mechanisms and often shows reversibility within days, but lacks standardized diagnostic criteria. The significance is to improve conceptual clarity and diagnostic approach for clinicians managing acute cardiac dysfunction in sepsis.

Naimi A, Rodriguez M, Qadeer YK et al. · American heart journal plus : cardiology research and practice · (2026) · View on PubMed ↗ · Free PDF ↗

Cardiac MRI Identifies Subclinical Myocardial Tissue Abnormalities in Individuals With Hepatitis C Regardless of Myocardial Damage Markers or Fibrosis Stage.

The study used 3T cardiac magnetic resonance (CMR) to measure cardiac extracellular volume (ECV) fraction in 10 untreated individuals with chronic hepatitis C virus (HCV) infection prior to therapy, compared with age-matched healthy volunteers. HCV-infected participants had higher ECV fraction than controls (0.30±0.03 vs 0.26±0.03, p=0.0036), and this increase was present regardless of myocardial damage markers, hypertension, smoking pack-years, or liver fibrosis stage. These findings suggest subclinical extrahepatic myocardial inflammation/fibrosis occurs before overt liver fibrosis, supporting early HCV treatment to reduce downstream cardiovascular involvement.

D’Amore A, Sirajuddin A, George N et al. · Journal of viral hepatitis · (2026) · View on PubMed ↗

The Diagnostic and Prognostic Value of Multi-Chamber Strain Analysis by Cardiac MRI in Amyloidosis.

Researchers retrospectively evaluated multi-chamber myocardial strain on cardiac MRI in 47 patients with cardiac amyloidosis and correlated strain with native T1 mapping and late gadolinium enhancement (LGE), with follow-up for major adverse cardiovascular events (MACE). The key finding was that strain parameters across ventricles and atria showed diagnostic and prognostic utility and correlated with amyloid imaging metrics (native T1 and QALE/LGE measures). This supports multi-chamber strain as a potentially powerful CMR biomarker for risk stratification in amyloidosis.

Chilkuri SK, Dsouza R, Houbois C et al. · Journal of thoracic imaging · (2026) · View on PubMed ↗

Filamin C Genetic Cardiomyopathy Presenting as Acute Myocardial Injury.

This case report studied a 46-year-old man with acute myocardial injury characterized by a nonischemic imaging pattern on cardiac magnetic resonance (CMR). CMR showed extensive ring-like subepicardial late gadolinium enhancement involving 10 left ventricular segments without myocardial edema, and subsequent genetic testing identified a pathogenic FLNC (filamin C) variant; follow-up at 4 months demonstrated persistent fibrosis with preserved ventricular function and no arrhythmias. The findings support FLNC genetic cardiomyopathy as a cause of acute myocardial injury with distinctive ring-like LGE, emphasizing the role of CMR and genetic testing in nonischemic troponin presentations.

Alexandrino FB, Curtis B, Nguyen C et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗

A case report of nonrheumatic myocarditis following group G streptococcus pharyngitis.

This case report studied nonrheumatic myocarditis following group G streptococcal pharyngitis in a 22-year-old man. The key finding was that cardiac magnetic resonance imaging showed focal myocardial hyperintensity on T2-weighted imaging with elevated T2 values consistent with myocarditis after a rare post-bacterial trigger. Clinically, it highlights that bacterial-associated myocarditis (specifically group G streptococcus) can present with MRI-confirmable myocardial inflammation and should be considered in similar post-infectious chest pain presentations.

Perkins SJ, Lim JGS, Gans C et al. · Radiology case reports · (2026) · View on PubMed ↗ · Free PDF ↗

Impact of Microvascular Obstruction on Left Atrial and Ventricular Myocardial Deformation and In-hospital Complications in Reperfused ST-segment Elevation Myocardial Infarction Patients.

This retrospective study evaluated how microvascular obstruction (MVO), defined on late gadolinium enhancement (LGE) cardiovascular magnetic resonance (CMR), affects left atrial and ventricular myocardial deformation and in-hospital complications in 95 reperfused ST-segment elevation myocardial infarction (STEMI) patients undergoing CMR within 7 days. Patients with MVO showed worse myocardial deformation parameters and higher rates of in-hospital complications than those without MVO. These findings support using CMR LGE-defined MVO as an early prognostic marker for adverse remodeling and short-term clinical risk after reperfused STEMI.

Cau R, Pinna A, Bassareo PP et al. · Journal of thoracic imaging · (2026) · View on PubMed ↗

Incremental Prognostic Value of Pericardial Adipose Tissue Radiomic Phenotype Based on Cardiac MRI in Patients With End-Stage Renal Disease.

This retrospective multicenter study assessed whether pericardial adipose tissue (PEAT) radiomic features extracted from cardiac MRI (including 3.0 T cine and T2/T2* mapping) predict major adverse cardiac events (MACE) in 248 end-stage renal disease (ESRD) patients. PEAT radiomic phenotype provided incremental prognostic value for MACE beyond conventional PEAT volume, with performance validated in an independent cohort. The results suggest PEAT radiomics as a noninvasive imaging biomarker to refine cardiovascular risk stratification in ESRD.

Zhang TY, Liu Y, Chen SZ et al. · Journal of magnetic resonance imaging : JMRI · (2026) · View on PubMed ↗

Systemic inflammation, myocardial fibrosis, and subclinical cardiovascular disease in people living with HIV.

This cross-sectional pilot study examined matched male veterans with and without HIV receiving care at the Providence VA Medical Center to assess how systemic inflammation relates to myocardial fibrosis and subclinical cardiovascular disease using questionnaires, stress testing, echocardiography, cardiac MRI, coronary calcium scoring, and blood inflammatory biomarkers. The key finding was that people living with HIV showed evidence consistent with greater systemic inflammation and more myocardial fibrosis/subclinical cardiac disease compared with controls, linking inflammatory status to cardiac structural changes. These results support a mechanistic role for chronic inflammation in premature cardiovascular aging in HIV and suggest that cardiac MRI–based fibrosis assessment and inflammatory biomarker profiling could help identify higher-risk patients for earlier intervention.

Simkevich M, Chen YY, Parent M et al. · American heart journal · (2026) · View on PubMed ↗ · Free PDF ↗

Cardiac MRI mapping, quantitative imaging methods, and physics

A Comparison of Tissue Property Values Estimated Using Conventional Cardiac MRF and MT-Cardiac MRF.

This study compared tissue property values estimated using conventional cardiac magnetic resonance fingerprinting (cMRF) versus magnetization-transfer–modeled cardiac MRF (MT-cMRF) for T1 and T2 quantification. Explicit modeling of magnetization transfer during reconstruction improved estimation of free-water and bound-pool parameters (T1f, T2f, and bound pool fraction) compared with dictionaries that ignore MT processes, supported by simulations, phantom validation, and data from 14 healthy subjects. The work is significant because MT-aware cMRF may reduce bias and improve quantitative accuracy for myocardial tissue characterization in clinical imaging.

Kaplan S, Liu Z, Hamilton J et al. · Magnetic resonance in medicine · (2026) · View on PubMed ↗ · Free PDF ↗

The importance of spatial resolution in detecting chronic myocardial iron remnants following hemorrhagic myocardial infarction with T2* MRI.

This study investigated how spatial resolution affects detection of chronic myocardial iron remnants after hemorrhagic myocardial infarction (hMI) using T2* cardiac MRI, combining digital phantom simulations and ex vivo swine hearts (n=10) with 8-week hMI. Across voxel sizes (0.4–2.0 mm in-plane; 2–8 mm slice thickness) and multiple signal-to-noise ratio (SNR) levels, the authors assessed detection performance of iron deposits. Scientifically, it provides imaging-physics guidance on optimal T2* acquisition parameters to reliably visualize chronic iron from hMI, which is linked to worse outcomes.

Zhang X, Yang HJ, Dharmakumar R · Biomedical physics & engineering express · (2026) · View on PubMed ↗ · Free PDF ↗

Sustainable Low-Field Cardiovascular Magnetic Resonance in Changing Healthcare Systems-An Update.

This update reviewed advances enabling sustainable low-field cardiovascular magnetic resonance (LF CMR), particularly around 0.55 Tesla, for cardiac structure/function and tissue characterization in settings with limited resources. The key finding was that optimized hardware (e.g., gradient coils and RF systems) and AI-driven reconstruction can maintain strong diagnostic performance despite lower signal-to-noise ratios. The scientific significance is improved feasibility and scalability of CMR in low- and middle-income countries and other constrained healthcare systems.

Umair M, Marey A, Murali S et al. · NMR in biomedicine · (2026) · View on PubMed ↗ · Free PDF ↗

Simultaneous multi-slice Cardiac Diffusion Tensor Imaging with variable CAIPIRINHA shifts and artefact-aware AI.

This methodological study developed ORCAS, a simultaneous multi-slice (SMS) cardiac diffusion tensor imaging (cDTI) framework using variable CAIPIRINHA shifts and artefact-aware AI reconstruction. The approach targets long acquisition times caused by repeated averaging for SNR and reduces inter-slice leakage artefacts by decohering SMS artefacts across repetitions. The significance is that ORCAS could make in-vivo myocardial microstructure imaging faster and more reliable, enabling broader clinical and research use of cDTI.

Tänzer M, Lim EJ, Qiu HH et al. · Medical image analysis · (2026) · View on PubMed ↗ · Free PDF ↗

Optimizing Cine Cardiac MRI: Technical Advances and Clinical Applications.

This article studied technical advances for optimizing cine cardiac MRI acquisition and their clinical applications, focusing on how pulse sequence parameters (TR, TE, flip angle, bandwidth) and constraints (off-resonance effects, SAR limits, susceptibility artifacts) affect image quality. The key finding was that optimizing these parameters—especially for balanced steady-state free precession (bSSFP) at ≥3T—can improve signal-to-noise ratio and temporal resolution while mitigating artifacts. The significance is practical: better cine cardiac MRI performance can enhance noninvasive cardiac function assessment in routine and challenging scanning conditions (e.g., limited breath-hold or arrhythmia).

Dehghani S, Rajabi A, Rahmati A et al. · Journal of magnetic resonance imaging : JMRI · (2026) · View on PubMed ↗

Improved Myocardial Sodium Quantification at 7 T Using Interleaved 23Na/1H pTx MRI With Motion and Anatomy-Based B1 Correction.

This study investigated improved myocardial 23Na quantification at 7 T by combining interleaved 23Na/1H pTx MRI with retrospective respiratory and cardiac motion correction and a novel anatomy-based B1 bias field correction. Using 1H-derived segmentation (via nnUNet) to drive motion correction and to estimate B1 transmit/receive bias for 23Na, the method improved accuracy and repeatability of sodium measurements. Scientifically, it advances quantitative cardiac sodium MRI toward more reliable assessment of myocardial tissue composition at ultra-high field.

Ruck L, Egger N, Zobler B et al. · Magnetic resonance in medicine · (2026) · View on PubMed ↗ · Free PDF ↗

Enhanced 2D Spiral Cine DENSE MRI Using Low-Rank Denoising for Improved Apparent Signal-to-Noise Ratio, Spatial Resolution, Efficiency, Accuracy, and Accessibility.

This study developed and tested a low-rank denoising method for spiral cine displacement encoding with stimulated echoes (DENSE) MRI to improve signal-to-noise ratio, spatial resolution, efficiency, accuracy, and usability at lower field strength. In 36 human subjects scanned at 3 T (and additional high-resolution acquisitions in 10 healthy volunteers), the denoising approach enhanced DENSE performance compared with standard reconstructions. The technique improves accessibility of quantitative myocardial displacement imaging for both healthy and heart disease populations.

Shih SF, Wu Y, Li S et al. · Magnetic resonance in medicine · (2026) · View on PubMed ↗ · Free PDF ↗

Cardiac MRI/CT/PET diagnostic pathways and multimodality imaging

Characteristics and outcomes of patients undergoing coronary computed tomography angiography for suspected acute coronary syndrome in the emergency department.

This retrospective study characterized outcomes of patients with suspected acute coronary syndrome (ACS) who underwent coronary computed tomography angiography (CCTA) in the emergency department (ED) (n=198). The key finding was the observed event rate for the primary composite endpoint of major adverse cardiovascular events (MACE: all-cause death, acute myocardial infarction, or myocardial revascularization) after ED CCTA triage. Clinically, these data help define the prognostic value of ED CCTA pathways for suspected ACS.

Ciliberti G, Compagnucci P, Finori L et al. · The international journal of cardiovascular imaging · (2026) · View on PubMed ↗

A case of cardiac lymphangioma: diagnosis suggested by cardiac CT and MRI and successful conservative management.

This case report studied a 78-year-old woman with cardiac lymphangioma, using cardiac CT and cardiac MRI to establish diagnosis and guide management. The key finding was that multimodality imaging showed characteristic features (non-enhancing lobulated mass on CT and multilocular cystic high T2 signal on CMR) consistent with lymphangioma, enabling successful conservative management. The clinical significance is that CT/CMR can provide decisive diagnostic support for this rare tumor and may allow non-surgical management when appropriate.

Kurosaka E, Matsuda J, Yanagiya N et al. · Journal of cardiology cases · (2026) · View on PubMed ↗

Atypical Case of Takayasu Aortitis Presenting as Embolic Stroke With Concomitant Massive Thoracic Artery Aneurysm.

This case report studied a 44-year-old woman with hypertension who presented with aphasia and multifocal embolic ischemic stroke, alongside a massive ascending thoracic artery aneurysm and transverse arch aneurysm consistent with atypical Takayasu aortitis. Open surgical repair with a Dacron graft was performed and pathology showed granulomatous inflammation suggestive of autoimmune or infectious etiology. The report highlights that Takayasu aortitis can present atypically with embolic stroke and large thoracic aortic aneurysms, supporting early imaging and surgical-pathologic confirmation to guide management.

Henson JC, Myers JH, Cummins M et al. · Clinical case reports · (2026) · View on PubMed ↗ · Free PDF ↗

Comparison of Cardiac MR with PET CT in Evaluation of Myocardial Viability: Single-Center Experience.

This prospective single-center study evaluated 28 adult patients with PET-CT perfusion/metabolism matched or mismatched defects to compare cardiac MRI parameters of myocardial viability against PET-CT as the reference standard. Key MRI measures included end-diastolic wall thickness (EDWT), regional wall motion abnormalities, and late gadolinium enhancement (LGE) for infarcted tissue, with EDWT assessed both manually and using semiautomatic software. The findings are intended to refine which cardiac MRI viability metrics best track PET-CT viability, supporting more accurate selection of patients for revascularization or risk stratification.

Arafath MY, Debi U, Singhal M et al. · The Indian journal of radiology & imaging · (2026) · View on PubMed ↗ · Free PDF ↗

Computational modeling of left ventricular flow using PC-CMR-derived four-dimensional wall motion.

This engineering study developed computational models of left ventricular (LV) blood flow by integrating cardiac MRI-derived four-dimensional wall motion with PC-CMR (phase-contrast CMR) to drive individualized fluid dynamics simulations. The approach aims to couple imaging-based structural motion quantification with computational fluid dynamics (CFD) to characterize LV hemodynamics without fully coupled fluid-solid modeling. The significance is a step toward personalized, imaging-driven hemodynamic modeling that could improve understanding and prediction of cardiac disease mechanisms.

Peighambari SB, Mukherjee T, Mendiola EA et al. · International journal of engineering science · (2026) · View on PubMed ↗

In vivo evidence of blood flow slippage: failure of the no-slip boundary condition assumption.

The study investigated whether the in vivo “no-slip” boundary condition holds for blood flow by using 4D flow CMR of the descending thoracic aorta in seven healthy adult volunteers combined with Navier–Stokes modeling and data assimilation. Near-wall tangential velocities were estimated at approximately 30–80% of the measured values, indicating failure of the strict no-slip assumption. Scientifically, this supports revising cardiovascular fluid dynamics boundary conditions for more accurate wall shear stress and hemodynamic modeling.

Jarolímová A, Hron J, Tůma K et al. · American journal of physiology. Heart and circulatory physiology · (2026) · View on PubMed ↗

Diagnosis of cardiac pathology on acute electrocardiographic-gated thoracic computed tomography: guidance for the general radiologist.

This article provided guidance for general radiologists on diagnosing cardiac pathology using acute electrocardiographic-gated thoracic computed tomography (CT) angiography datasets. The key message was that, beyond acute aortic syndrome evaluation, the same CT dataset can reveal other potentially life-threatening cardiac causes (including coronary atheromatous disease and related complications) that are often overlooked or misinterpreted. The clinical significance is reduced diagnostic error and improved recognition of cardiac pathology in routine radiology workflows.

Manghat NE, Greco F, Harries I et al. · Clinical radiology · (2026) · View on PubMed ↗

Pathological Q Waves in a Young Patient Without Ischemic Heart Disease.

This JACC Case Reports article described an 18-year-old asymptomatic man with pathological septal Q waves on electrocardiography but without known ischemic heart disease. The key clinical finding was that multimodality cardiac imaging—especially cardiac magnetic resonance for tissue characterization—was central to differential diagnosis and risk stratification in this atypical ECG presentation. The significance is that pathological Q waves in young patients require careful imaging-based evaluation to identify non-ischemic causes and guide management.

Figueroa-Galván FS, Alanís-Naranjo JM, González-Najera MF et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗

Apical Hypertrophic Cardiomyopathy in ATTR Val142Ile Carrier: When Genes and Phenotype Diverge.

This case report studied a 61-year-old African-American man with apical hypertrophic cardiomyopathy (ApHCM) who was found to carry the pathogenic transthyretin (TTR) Val142Ile (V142I) variant. Despite genotype positivity, technetium-99m pyrophosphate scintigraphy (H/CL 1.01, visual grade 0) excluded transthyretin cardiac amyloidosis, and cardiac magnetic resonance showed apical-predominant hypertrophy with patchy late gadolinium enhancement consistent with ApHCM rather than ATTR cardiomyopathy. The report highlights that TTR V142I can have incomplete, age-dependent penetrance and that multimodality imaging is essential to distinguish ATTR-CM from phenocopies to guide appropriate management.

Khayat O, Moumneh MB, Salman O et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗

Imaging of Myocardial Carcinoid Metastasis.

This JACC case series studied two patients with metastatic neuroendocrine tumors (NETs) presenting with isolated myocardial carcinoid metastases. In both cases, cardiac metastases were first detected on Gallium-68 DOTATATE PET/CT and then characterized with cardiac magnetic resonance (CMR), while transthoracic echocardiography had limited ability to identify myocardial involvement. The report highlights the clinical importance of multimodality imaging—especially DOTATATE PET/CT plus CMR—for detecting and characterizing cardiac metastases in NET patients.

Ranganath S, Ynalvez L, Ryoo Ali HJ et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗

Evaluation of new vectorcardiography algorithms for identifying left ventricular hypertrophy and impaired systolic function.

This prospective study evaluated new vectorcardiography (VCG) algorithms for identifying left ventricular hypertrophy (LVH) and impaired systolic function in a clinical cohort, using cardiac magnetic resonance imaging as the reference standard. The key finding was that VCG can provide diagnostic performance for LVH and systolic impairment that is meaningfully compared against CMR, supporting VCG as a potentially rapid, scalable screening tool. Scientifically and clinically, it positions VCG as an alternative to routine ECG for earlier detection of subtle structural heart disease when CMR is not feasible for screening.

Salatzki J, Schwarz AK, Wolfsteller S et al. · Journal of electrocardiology · (2026) · View on PubMed ↗ · Free PDF ↗

Cardiac Safety Outcomes in Delandistrogene Moxeparvovec Clinical Trials for Duchenne Muscular Dystrophy with Up to 5 Years of Follow-up.

This study evaluated cardiac safety outcomes of the gene transfer therapy delandistrogene moxeparvovec (delivered to express functional dystrophin) in clinical trials for Duchenne muscular dystrophy (DMD) with up to 5 years of follow-up. Across trials (101, 102, ENDEAVOR, and EMBARK) with regular adverse-event monitoring and serial echocardiography (with exclusion of patients with LVEF <40%), the therapy demonstrated an overall cardiac safety profile over extended follow-up. The findings are significant for long-term risk assessment and clinical monitoring strategies for DMD patients receiving dystrophin gene therapy.

Veerapandiyan A, Bourke J, Soslow JH et al. · Cardiology and therapy · (2026) · View on PubMed ↗ · Free PDF ↗

Cardiac magnetic resonance imaging assessment of Del Nido versus cold blood cardioplegia in patients with low ejection fraction undergoing combined coronary artery bypass graft and mitral valve replacement: Early outcomes.

This prospective single-center study compared Del Nido cardioplegia (DNC) versus conventional cold blood cardioplegia (CBC) in patients with reduced left ventricular ejection fraction undergoing concomitant coronary artery bypass grafting (CABG) and mitral valve replacement (MVR), using cardiac magnetic resonance imaging to assess early myocardial functional recovery. The two cardioplegia strategies were evaluated for differences in early recovery metrics derived from CMR in 42 patients with LVEF <45%. The findings are significant for optimizing myocardial protection strategies in high-risk cardiac surgery patients with impaired systolic function.

Gode S, Polat M, Eroğlu Polat A et al. · Turk gogus kalp damar cerrahisi dergisi · (2026) · View on PubMed ↗ · Free PDF ↗

Atorvastatin and left ventricular strain during anthracycline-based chemotherapy.

In the randomized STOP-CA trial, this study evaluated whether atorvastatin protects against anthracycline-associated declines in left ventricular (LV) deformation measured by cardiac MRI feature tracking (FT) in lymphoma patients treated with anthracyclines. Atorvastatin did not meaningfully prevent reductions in global longitudinal strain (GLS) and global circumferential strain (GCS) over 12 months compared with placebo. Clinically, the findings argue against routine cardioprotection with atorvastatin solely to preserve MRI-derived LV strain during anthracycline chemotherapy.

Juhasz V, Quinaglia T, Drobni ZD et al. · International journal of cardiology · (2026) · 1 citations · View on PubMed ↗ · Free PDF ↗

Arrhythmias and electrophysiology risk stratification

Revisiting the Link Between Substrate and Ventricular Tachycardia Rate: The Critical Role of Conduction Isthmus Structure and Function.

This prospective cohort study in 62 patients undergoing ablation for scar-related ventricular tachycardia (VT) compared global scar substrate metrics versus conduction-isthmus-specific structure/function features to predict VT rate. The key finding was that conduction-isthmus properties provided critical predictive value for VT rate beyond global substrate measures. Clinically, this could refine risk stratification and ablation targeting by focusing on conduction isthmus characteristics rather than relying solely on global scar metrics.

Guichard JB, Castrillo-Golvano L, Molero-Pereira S et al. · Heart rhythm · (2026) · View on PubMed ↗ · Free PDF ↗

Treatment of Premature Ventricular Contractions: A Review of Medical Therapy, Catheter Ablation, and Emerging Treatments.

This narrative review studied the management of premature ventricular contractions (PVCs) by comparing medical therapy, catheter ablation, and emerging treatments across patients with and without structural heart disease. The key finding was that treatment choice should be driven by symptom burden, PVC frequency, ventricular function, and underlying myocardial disease, given the risk of PVC-induced cardiomyopathy and potential malignant arrhythmia triggers. Clinically, it supports a risk-stratified approach to PVC evaluation and therapy selection.

Elattar S, Hodhod A, Basha NR et al. · Cardiology in review · (2026) · View on PubMed ↗

A Case of Brugada Syndrome… or Something Else? Behind Type 1 Brugada Pattern.

This case report studied a 51-year-old man with syncope during a febrile illness who had a transient spontaneous type-1 Brugada ECG pattern. Holter monitoring revealed multifocal ventricular ectopy including non-sustained ventricular tachycardia (NSVT), and the authors emphasize that overt myocardial scar or biventricular arrhythmogenic substrate should prompt consideration of diagnoses other than primary Brugada syndrome. Clinically, it underscores the need for careful structural assessment (e.g., to detect scar/arrhythmogenic substrate) when Brugada-like ECG patterns occur transiently with systemic illness.

Scarà A, Borrelli A, Romano S et al. · Clinical case reports · (2026) · View on PubMed ↗ · Free PDF ↗

Unexplained Supraventricular Tachycardia and Myocardial Injury After Bitter Orange Supplement Use in a Young Woman.

This case report studied a 38-year-old woman who developed unexplained supraventricular tachycardia and myocardial injury after using a bitter orange (Citrus aurantium) weight-loss supplement containing p-synephrine. She presented with palpitations and atypical chest pain, had SVT terminated with 6 mg IV adenosine, and showed a marked rise in high-sensitivity troponin I from 17.9 to 1,395.7 ng/L with subsequent exclusion of pulmonary embolism on computed tomography pulmonary angiography. The case is significant because it documents a sympathomimetic supplement–associated arrhythmia and myocardial injury, supporting careful medication/supplement history and prompt evaluation of cardiotoxicity.

Plaitis A, Grigoraki E, Karakosta M et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗

Malignant Mitral Valve Prolapse With Life-Threatening Ventricular Arrhythmias: A Multidisciplinary Team-Guided Stepwise Management.

This case report studied malignant arrhythmogenic mitral valve prolapse (MVP) in a 45-year-old woman with bileaflet myxomatous MVP, mitral annular disjunction, and mild mitral regurgitation who developed polymorphic ventricular tachycardia and recurrent ventricular fibrillation despite medical therapy and multiple ICD shocks. The key finding was that life-threatening ventricular arrhythmias can occur in malignant MVP even without severe MR and without detectable myocardial fibrosis on cardiac magnetic resonance imaging, emphasizing the value of combined electrical and mechanical risk markers for imminent sudden cardiac risk. Clinically, it supports a multidisciplinary, stepwise management approach and suggests that absence of fibrosis or severe MR should not preclude aggressive risk stratification and intervention in suspected malignant MVP.

Javadi N, Jahangir A, Galazka P et al. · JACC. Case reports · (2026) · 1 citations · View on PubMed ↗ · Free PDF ↗

Ischemia, microvascular dysfunction, and MINOCA/CME

Molecular mechanisms of coronary microembolization-induced MINOCA.

This article investigated the molecular mechanisms by which coronary microembolization (CME) leads to myocardial infarction with non-obstructive coronary arteries (MINOCA), focusing on the pathobiology underlying delayed diagnosis and therapy. The key finding is that the molecular basis of CME-driven MINOCA remains incompletely defined, limiting development of rapid diagnostic tools and targeted treatments. Clarifying CME molecular pathways is scientifically significant because it could enable earlier MINOCA diagnosis and more specific, mechanism-based therapy.

Iske J, Thau H, Mesfin JM et al. · Basic research in cardiology · (2026) · View on PubMed ↗

Stratified Medicine with Eplerenone for Myocardial Infarction or Injury and No obstructive Coronary Arteries: A Registry-Based Basket Trial.

This registry-based basket trial studied whether endotype-informed treatment with the mineralocorticoid receptor antagonist eplerenone improves outcomes in patients with suspected MINOCA/nonischemic myocardial injury stratified by coronary microvascular dysfunction. The study implemented coronary microvascular dysfunction assessment to identify an eplerenone-targeted subgroup, aiming to test a stratified therapy approach where evidence-based MINOCA treatments are lacking. If effective, this would support a precision-cardiology strategy linking coronary microvascular dysfunction endotypes to targeted pharmacotherapy with eplerenone in MINOCA/nonischemic myocardial injury.

Sykes R, Tan D, McKinley G et al. · American heart journal · (2026) · View on PubMed ↗ · Free PDF ↗

Stress native mapping does not distinguish patients with previous myocardial infarction with non-obstructive coronary arteries from healthy volunteers.

Researchers tested whether non-contrast adenosine stress native T1 and T2 mapping on 1.5T CMR can distinguish patients with previous myocardial infarction with non-obstructive coronary arteries (MINOCA) from healthy volunteers. In 15 MINOCA patients with normal CMR, stress native T1/T2 and quantitative perfusion mapping did not differentiate them from age- and sex-matched controls. Clinically, this suggests that stress native mapping may be insufficient for detecting microvascular dysfunction in MINOCA when standard CMR is normal, guiding future biomarker selection.

Andersson DF, Johansson RS, Tornvall P et al. · Clinical physiology and functional imaging · (2026) · View on PubMed ↗ · Free PDF ↗

Detection of Coronary Microvascular Dysfunction in Diabetic Mice Using Arterial Spin Labeling Cardiac MRI: A Multimodality Imaging Comparison.

This prospective animal study compared arterial spin labeling cardiac MRI (ASL-MRI) and transthoracic echocardiography (TTE) for detecting coronary microvascular dysfunction (CMD) in type 1 and type 2 diabetic mouse models, including early-stage 8-week T2DM. ASL-MRI and TTE showed differing sensitivity for CMD detection, and functional imaging indices correlated with histological measures of microvascular injury and myocardial remodeling across T1DM, T2DM, and control groups. The work supports ASL-MRI as a noninvasive multimodality tool for CMD characterization in diabetes and provides a framework for linking imaging biomarkers to pathology.

Miao Q, Shi Y, Li B et al. · Journal of magnetic resonance imaging : JMRI · (2026) · 1 citations · View on PubMed ↗

Heart failure phenotyping, prognosis, and reverse remodeling

Diagnostic Tests for Stage B Heart Failure.

This narrative review synthesized evidence on diagnostic tests for stage B heart failure (SBHF), focusing on identifying subclinical myocardial remodeling and early injury before symptom onset. It highlights transthoracic echocardiography—particularly speckle tracking echocardiography—as a cornerstone diagnostic modality, alongside biomarkers such as natriuretic peptides and high-sensitivity cardiac troponins. The clinical significance is improved selection and interpretation of diagnostic tools to detect SBHF earlier and guide preventive strategies.

Dang HNN, Luong TV, Huynh Q et al. · Current cardiology reports · (2026) · View on PubMed ↗ · Free PDF ↗

Clinical Course and Predictors of Heart Failure in Asymptomatic Obstructive Hypertrophic Cardiomyopathy.

This multicenter retrospective cohort study evaluated 341 asymptomatic patients with obstructive hypertrophic cardiomyopathy (NYHA I, LVEF >50%, LV outflow tract gradient ≥30 mmHg) across four centers (2003–2023) using transthoracic echocardiography and longitudinal follow-up to identify predictors of progression to symptomatic heart failure. The study focused on clinical and echocardiographic factors associated with heart failure development in patients who were initially asymptomatic. These findings can refine risk prediction and monitoring strategies for obstructive HCM before symptoms emerge.

Schulz A, Maron MS, Peng LW et al. · Journal of the American Heart Association · (2026) · View on PubMed ↗ · Free PDF ↗

Diagnostic and Prognostic Utility of Mitral Annular Plane Systolic Excursion: A Systematic Review and Meta-Analysis.

This systematic review and meta-analysis assessed the diagnostic and prognostic utility of mitral annular plane systolic excursion (MAPSE) across imaging modalities including transthoracic echocardiography, transesophageal echocardiography, and cardiovascular magnetic resonance. The key finding was that MAPSE—an easily measured longitudinal motion metric—has evidence supporting its clinical value for diagnosis and prognosis, with cross-modality measurement feasibility and potential guideline relevance. Establishing MAPSE’s performance could enable faster, standardized assessment of cardiac function and outcomes in routine practice.

Falconer D, Fröjdh F, Wyeth N et al. · Journal of the American Heart Association · (2026) · View on PubMed ↗ · Free PDF ↗

Polypill for heart failure with reduced ejection fraction: the POLY-HF randomized trial.

The POLY-HF randomized trial tested whether a once-daily polypill strategy improves cardiac function in adults with heart failure with reduced ejection fraction (LVEF ≤40%) compared with rapid uptitration of individual guideline-directed medical therapy. Participants were randomized to a polypill containing metoprolol succinate (25/50/100/150 mg), spironolactone 12.5 mg, and empagliflozin 10 mg versus enhanced standard titration at two centers in a predominantly underserved population. If effective, this approach could improve real-world implementation of guideline-directed therapy and outcomes in HFrEF by simplifying medication initiation and titration.

Pandey A, Keshvani N, Rizvi SK et al. · Nature medicine · (2026) · View on PubMed ↗

Assessment of left atrioventricular coupling index in hypertrophic cardiomyopathy: improving risk stratification with cardiac magnetic resonance (CMR).

This retrospective study assessed the prognostic value of the left atrioventricular coupling index (LACI), defined as left atrial end-diastolic volume divided by left ventricular end-diastolic volume, in 2,240 hypertrophic cardiomyopathy (HCM) patients using clinical data and cardiac magnetic resonance (CMR). LACI was evaluated for predicting sudden cardiac death (SCD) events and for incremental risk stratification beyond guideline-based models, alongside CMR measures including late gadolinium enhancement (LGE) and left ventricular ejection fraction (LVEF). If validated, LACI could improve SCD risk prediction in HCM by adding a CMR-derived marker of left atrioventricular coupling to existing guideline frameworks.

Zhang D, Qian Y, Gu Z et al. · Clinical radiology · (2026) · View on PubMed ↗

Analysis of cardiac magnetic resonance characteristics in patients with ejection fraction preserved heart failure.

This retrospective CMR study analyzed 117 heart failure with preserved ejection fraction (HFpEF) patients, 65 healthy controls, and 62 high-risk individuals to quantify epicardial adipose tissue (EAT) volume and relate it to left ventricular function and outcomes. Over follow-up, EAT volume and CMR-derived left ventricular strain were assessed for association with heart failure readmission or all-cause death, aiming to clarify prognostic value in HFpEF. The work is clinically relevant because CMR-based EAT quantification could help refine risk assessment and potentially guide management strategies in HFpEF.

Zhang Y, Li Y, Yang X et al. · Clinical radiology · (2026) · View on PubMed ↗

Cardiac magnetic resonance-derived atrioventricular coupling index for predicting left ventricular reverse remodeling in dilated cardiomyopathy.

This retrospective study evaluated whether a cardiac magnetic resonance-derived left atrioventricular coupling index (LACI) predicts left ventricular reverse remodeling (LVRR) in 64 hospitalized dilated cardiomyopathy (DCM) patients receiving standardized guideline-directed therapy. Patients were classified into LVRR versus non-LVRR groups using echocardiographic criteria within one year, and multivariable models were built to test LACI’s predictive value, including comparisons with models incorporating left atrial strain or left ventricular strain. If LACI improves prediction, it could support CMR-based stratification of DCM patients likely to achieve reverse remodeling under medical therapy.

Ke J, Zhang C, Wang X et al. · Clinical radiology · (2026) · View on PubMed ↗

Cardiovascular imaging in special populations (pediatrics, pregnancy, rare diseases)

Fully quantitative CMR rest perfusion reveals myocardial perfusion abnormality in Kawasaki disease: Association with left ventricular Remodeling.

This prospective single-center study measured fully quantitative cardiac magnetic resonance (CMR) rest perfusion in children with Kawasaki disease (KD) (n=87) to map myocardial blood flow abnormalities and relate them to left ventricular (LV) remodeling. Myocardial blood flow (MBF), corrected for heart rate–blood pressure product (MBFcor), was associated with patterns of LV remodeling, linking perfusion injury to subsequent structural changes. These findings are clinically significant because quantitative CMR perfusion may help identify KD patients at risk for adverse LV remodeling.

Zhou Z, Ye P, Wang C et al. · International journal of cardiology · (2026) · View on PubMed ↗

Sudden Cardiac Arrest and Takotsubo-Like Cardiomyopathy as the Initial Presentation of Primary Carnitine Deficiency.

This JACC Case Reports article describes an 18-year-old female with primary carnitine deficiency (PCD) presenting with ventricular fibrillation cardiac arrest and a Takotsubo-like cardiomyopathy phenotype on cardiac magnetic resonance (CMR). Genetic testing identified a homozygous pathogenic SLC22A5 variant (c.43G>T; p.Gly15Trp), establishing autosomal recessive PCD as the cause of the initial cardiac presentation. The clinical significance is that recognizing PCD with CMR patterns and confirming SLC22A5 mutations can enable timely, treatable management after life-threatening arrhythmia.

Talasani N, Przybylski R, Delaney MA et al. · JACC. Case reports · (2026) · View on PubMed ↗

Cardiac Imaging Predictors of Ventricular Recovery in Pediatric Patients Undergoing Aortic Valve Intervention for Regurgitation.

This retrospective study of patients younger than 30 years with moderate-to-severe chronic aortic regurgitation undergoing aortic valve surgery evaluated preoperative echocardiogram and cardiac MRI predictors of postoperative left ventricular (LV) recovery. The key finding was that specific baseline imaging parameters from echocardiography and CMR were associated with LV reverse remodeling/functional recovery after intervention. This is clinically significant because it may improve timing and selection for pediatric/young adult aortic valve intervention beyond adult-derived surgical thresholds.

Flerlage EK, Huma LC, Gandhi R et al. · Pediatric cardiology · (2026) · View on PubMed ↗

Use of advanced cardiovascular imaging in rheumatic immune-mediated inflammatory diseases.

This retrospective multi-center quality improvement study examined real-world use of advanced cardiovascular imaging—cardiac magnetic resonance (CMR), CT coronary angiography (CTCA), and PET—in adults with less common/rare rheumatic immune-mediated inflammatory diseases (IMIDs) including systemic lupus erythematosus, systemic sclerosis, inflammatory myopathy, vasculitis, and primary Sjögren’s disease. Imaging utilization varied across hospitals and IMID subgroups, indicating heterogeneity in practice patterns for cardiovascular risk evaluation. These results are important for informing future guideline development and designing studies to standardize when and how advanced imaging is used in rare rheumatic IMIDs.

Gumber L, Meghji MA, Kakkar V et al. · Rheumatology (Oxford, England) · (2026) · View on PubMed ↗ · Free PDF ↗

Discordant Cardiomyopathy Phenotypes in Siblings With Homozygous FKRP c.1100T>C.

This case report studied two South African Afrikaner siblings with discordant cardiac phenotypes who were both homozygous for the FKRP c.1100T>C (p.Ile367Thr) variant. The brother developed progressive cardiomyopathy with dilatation and extensive late gadolinium enhancement over 7 years, whereas the sibling’s cardiac phenotype differed despite the same homozygous genotype. The report underscores that FKRP genotype does not deterministically predict cardiac phenotype severity or pattern, informing counseling and the need for individualized cardiac surveillance in FKRP-related disease.

Mahon N, Coad S, Kiamanesh O · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗

Fetal MRI for cardiopulmonary anomalies: what the pediatric cardiologist and surgeon need to know.

This review studied the role of fetal cardiac magnetic resonance imaging (fetal CMR) in prenatal evaluation of cardiopulmonary anomalies, focusing on how pediatric cardiologists and surgeons should integrate it with expert fetal echocardiography. The key finding was that fetal CMR provides high-resolution, multiplanar imaging with superior soft-tissue contrast and a wide field of view, enabling diagnostic or prognostic information when echocardiography is limited by technical/physiologic factors. Scientifically and clinically, it supports an evidence-based framework for using fetal CMR to inform counseling, delivery planning, and postnatal management.

Dadoun SE, Mokha S, Kooraki S et al. · Current opinion in cardiology · (2026) · View on PubMed ↗

A Stepwise Multimodality Imaging Approach to Out-of-Hospital Cardiac Arrest in Cystic Fibrosis.

This case report studied a 25-year-old man with cystic fibrosis who developed ventricular fibrillation during a pulmonary exacerbation and was evaluated for cardiac ischemia without ST-segment elevation using electrocardiography, high-sensitivity troponin, and transthoracic echocardiography. Despite an anterolateral T-wave inversion pattern and a marked troponin rise/fall with regional wall motion abnormalities, the presentation occurred in the setting of non-atherosclerotic triggers during illness. The report highlights the diagnostic challenge of OHCA without ST-elevation in young patients and the need for multimodality evaluation beyond coronary occlusion.

Frittella S, Iuvara G, Angeli F et al. · The American journal of cardiology · (2026) · View on PubMed ↗ · Free PDF ↗

Role of predelivery fetal echocardiography, cardiac magnetic resonance imaging and acute maternal hyperoxygenation in predicting urgency of neonatal balloon atrial septostomy in fetal dextro-transposition of the great arteries.

This prospective single-center cohort study of pregnancies with fetal dextro-transposition of the great arteries (TGA) with intact ventricular septum or a small VSD (≤4 mm) evaluated whether predelivery fetal echocardiography and cardiac magnetic resonance imaging (CMR) in room air and during acute maternal hyperoxygenation could predict neonatal hypoxia and the need for urgent balloon atrial septostomy (BAS) within 3 hours after birth. The key finding was that specific predelivery imaging features measured under these conditions were predictive of postnatal oxygenation failure and urgency of BAS. Clinically, using fetal echocardiography/CMR with maternal hyperoxygenation could improve perinatal risk stratification and enable earlier planning for urgent BAS in TGA.

Jaeggi E, Sun L, Saito M et al. · Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology · (2026) · View on PubMed ↗

Valvular heart disease and transcatheter/surgical planning

Trileaflet mitral valve in hypertrophic obstructive cardiomyopathy: A rare anatomical variant requiring surgical intervention.

This case report described a 68-year-old woman with hypertrophic obstructive cardiomyopathy who had a rare trileaflet mitral valve anatomy (anterior leaflet restriction with a clefted posterior leaflet) causing severe mitral regurgitation and left ventricular outflow tract obstruction (resting gradient up to 87 mmHg). Symptoms persisted despite beta-blocker therapy, and she underwent surgical intervention based on symptomatic and prognostic considerations using multimodal imaging with echocardiography and cardiac magnetic resonance. The report highlights an uncommon structural mechanism of obstruction/regurgitation in HOCM that may require surgery when medical therapy fails.

Kumar UA, Sitaranjan DR, Taghavi FJ · Perfusion · (2026) · View on PubMed ↗

An integrative approach to patient selection for mitral transcatheter edge-to-edge repair in secondary mitral regurgitation.

This review proposed an integrative patient-selection framework for mitral transcatheter edge-to-edge repair (M-TEER) in secondary mitral regurgitation by synthesizing randomized trial evidence (including MITRA-FR and COAPT) with proportionality concepts and multimodality imaging. The key message was that differences in echocardiographic selection and left-ventricular remodeling help explain divergent trial outcomes, implying that SMR severity should be interpreted relative to ventricular size and regurgitant context. Clinically, this supports more precise identification of patients most likely to benefit from M-TEER beyond guideline-directed medical therapy.

Brusosa M, Flores-Umanzor E, Horlick E · Current opinion in cardiology · (2026) · View on PubMed ↗

One Anatomy, Multiple Valve Choices: Interobserver Agreement in Selecting Transcatheter Pulmonary Valve.

This study evaluated interobserver agreement among six experienced observers selecting transcatheter pulmonary valve (TPVR) device type, size, and position using 3D patient-specific anatomies reconstructed from cardiac magnetic resonance images. Observers showed variable agreement for valve type (self-expanding vs balloon-expandable vs surgical approach) and for sizing/positioning across 60 pediatric and adult anatomies, highlighting that anatomical variability and interpretation differences can affect procedural planning. The results are significant for standardizing TPVR planning workflows and improving consistency in device selection to reduce planning-related procedural risk.

Pérez-Cualtán CE, Cabrales J, Garay F et al. · Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions · (2026) · View on PubMed ↗ · Free PDF ↗

Sex-based differences in mitral and tricuspid valve disease in the era of transcatheter therapies: a contemporary review.

This contemporary review studied sex-based differences in mitral and tricuspid valve disease presentation, imaging assessment, and management in the era of transcatheter therapies. The review summarizes evidence that women and men differ in epidemiology and pathophysiology of valvular disease and may experience different diagnostic and procedural considerations as transcatheter approaches expand. Scientifically, it emphasizes incorporating sex-specific factors into evaluation and procedural planning to improve outcomes in mitral and tricuspid transcatheter care.

Oletu H, Irivbogbe OA, Akhtar Y · Current problems in cardiology · (2026) · View on PubMed ↗

Transplant immunology and graft outcomes

CTLA4-Ig + Anti-IL-6/IL-6R Treatment Results in Long-term Allograft Survival and Function in Highly HLA-sensitized Patients.

This study evaluated the combination of CTLA4-Ig with anti–IL-6/IL-6 receptor therapy in highly HLA-sensitized (HS) transplant recipients at high risk for cell-mediated rejection (CMR) and antibody-mediated rejection (AMR). The key reported outcome was long-term allograft survival and preserved allograft function with this regimen in HS patients, addressing a clinical need for CNI-limiting scenarios where conversion to CNI-free strategies can provoke donor-specific antibody (DSA) rebound and rejection. The results support a potential immunotherapy strategy to improve long-term transplant outcomes in HS patients, particularly when calcineurin inhibitor (CNI) toxicity limits standard regimens.

Jordan SC, Chandran S, Ammerman N et al. · Transplantation direct · (2026) · View on PubMed ↗ · Free PDF ↗

Continuous Glucose Monitoring and Mortality Risk Among U.S. Veterans Receiving Dialysis With Diabetes.

Using linked national Veterans Affairs, U.S. Renal Data System, and Medicare data, the study assessed the association between continuous glucose monitoring (CGM) use versus non-CGM use and mortality among U.S. veterans receiving dialysis who also have diabetes. The key finding was that CGM use was associated with mortality risk differences compared with non-CGM use (direction and magnitude reported in the full text). Clinically, it suggests CGM may be a prognostic marker—and potentially a modifiable tool—for dysglycemia management in the dialysis population.

Narasaki Y, Kalantar-Zadeh K, Zisman-Ilani Y et al. · Diabetes care · (2026) · View on PubMed ↗ · Free PDF ↗

Machine learning, AI, and automated imaging/decision support

Strategies for resilient climate in smart cities mediated by Nash equilibrium and autonomous decision-makers.

This paper studied a decision-making framework for global warming mitigation in smart cities using Nash equilibrium, autonomous multi-agent systems, and machine learning, with each city modeled as an autonomous agent. The key finding was that integrating game-theoretic (Nash equilibrium) and autonomous agent decision-making with ML can generate city-specific policy strategies for pollution and climate-warming risk management. Scientifically, it provides a computational approach to coordinate mitigation policies across cities under interdependent dynamics.

Latha CM, Alvarado-Mentado M · Journal of environmental management · (2026) · View on PubMed ↗

Transforming Cardiac Imaging With Artificial Intelligence: Automation, Precision, and Clinical Integration in Echocardiography and Magnetic Resonance Imaging.

This narrative review synthesized evidence from 22 studies (2020–2026) on how artificial intelligence (AI) is transforming cardiac imaging in echocardiography and cardiac MRI (CMR). The key finding was that AI enables automated acquisition and segmentation in echocardiography and CMR, with performance for measures such as left ventricular ejection fraction and automated global longitudinal strain approaching expert-level accuracy while reducing analysis time and interobserver variability. Scientifically and clinically, it supports the feasibility of integrating AI into routine imaging workflows to improve precision and efficiency.

Choker AH · Echocardiography (Mount Kisco, N.Y.) · (2026) · View on PubMed ↗

Prediction of hypertension and restenosis under guideline-directed management in aortic coarctation: development and validation of machine-learning models.

This development-and-validation study used routinely collected electronic health records plus cardiovascular MRI and follow-up data from 160 individuals (218 visits) with aortic coarctation to build machine-learning models predicting hypertension and restenosis under guideline-directed management. The key finding was that ML models (including CatBoost, XGBoost, random forest, support vector classifiers, neural networks, and logistic approaches) could predict these long-term outcomes using clinical and imaging features. Clinically, this could enable earlier identification of patients at high risk for recurrent hypertension or restenosis after CoA treatment.

Fierley L, Versnjak J, Gabel G et al. · EClinicalMedicine · (2026) · View on PubMed ↗ · Free PDF ↗

Leveraging natural language processing artificial intelligence for automated data extraction of ejection fraction and strain from cardiovascular imaging reports.

This retrospective observational study applied natural language processing (NLP) to extract ejection fraction (EF) and related strain parameters from free-text cardiovascular imaging reports across modalities (echocardiography, nuclear cardiology, and CMR) in more than 4000 cancer survivors over 2000–2020. The key finding was that NLP was feasible for automated, longitudinal extraction of EF and related cardiac imaging measurements from heterogeneous report formats. This enables scalable real-world data generation for cardio-oncology research and may reduce manual chart abstraction burden.

Brown SA, BagheriMohamadiPour M, Sparapani R et al. · American heart journal plus : cardiology research and practice · (2026) · View on PubMed ↗ · Free PDF ↗

FedSemiDG: Domain generalized federated semi-supervised medical image segmentation.

This paper studied FedSemiDG, a domain generalized federated semi-supervised learning framework for medical image segmentation that addresses domain shift during federated aggregation. The key finding was that explicitly modeling domain generalization in federated semi-supervised learning improves performance in unseen domains compared with approaches that do not account for domain shift. Scientifically, it advances federated learning methods that can leverage unlabeled multi-center data while improving robustness to distribution changes across imaging sites.

Deng Z, Xu Z, Isshiki T et al. · Medical image analysis · (2026) · View on PubMed ↗

Large Language Models for Cardiac MRI Diagnosis Based on Standardized Text Descriptions.

This retrospective study evaluated large language models (LLMs) for cardiac MRI diagnosis using standardized text descriptions across multiple cardiac disease categories. The key finding was that LLM-based interpretation of structured descriptions could support diagnostic classification across hypertrophic cardiomyopathy, dilated cardiomyopathy, hypertensive heart disease, ischemic cardiomyopathy, constrictive pericarditis, cardiac amyloidosis, myocarditis, and normal controls. Clinically, it suggests a scalable pathway for less experienced centers to improve cardiac MRI diagnostic support without relying solely on image-based expertise.

Zhang H, Zhou J, Zhang C et al. · Journal of magnetic resonance imaging : JMRI · (2026) · View on PubMed ↗

Standardization, reproducibility, and interobserver variability

Variability in Cardiac Stress Test Interpretation: Agreement Between Enrollment Sites and Core Laboratories in the Global ISCHEMIA Trial.

This analysis assessed variability in interpretation of myocardial ischemia on cardiac stress testing between enrollment sites and core laboratories within the global ISCHEMIA trial population of patients with chronic coronary disease and moderate-to-severe ischemia. Interpretation differed across sites and core labs, indicating nontrivial inconsistency in how ischemia was classified despite a trial setting. These findings are clinically important because stress-test interpretation variability can influence eligibility, risk stratification, and downstream management decisions in chronic coronary disease.

O’Keefe E, Sperry BW, Jones PG et al. · Circulation. Population health and outcomes · (2026) · View on PubMed ↗

Correlation across modalities and clinical phenotypes between left Ventricular global longitudinal strain by echocardiography and cardiac magnetic resonance.

This systematic review and meta-analysis studied cross-modal agreement between left ventricular global longitudinal strain (LV-GLS) measured by speckle-tracking echocardiography (STE) and cardiac MRI feature tracking (CMR-FT) in the same cohorts. Pooled patient-level correlations (Pearson r) across modalities were quantified overall and by subgroup (healthy vs cardiovascular disease), showing how consistently STE and CMR-FT track LV-GLS across clinical phenotypes. The findings inform whether and how LV-GLS values can be compared or used interchangeably across imaging platforms in practice.

Pascalis L, Fazzini L, Pugliesi GM et al. · Current problems in cardiology · (2026) · View on PubMed ↗

Clinical decision frameworks and guideline/consensus development

Learning curves in Versius-assisted colorectal surgery: a risk-adjusted CUSUM analysis from a single center.

This retrospective single-center study analyzed learning curves for Versius-assisted colorectal cancer surgery in consecutive adults undergoing right hemicolectomy, sigmoid resection, or anterior rectal resection (Dec 2022–Aug 2025) using risk-adjusted CUSUM (RA-CUSUM) of skin-to-skin operative time. Procedure- and operator-specific learning trajectories were modeled after adjusting for patient- and procedure-related variables, identifying how performance improved over time for different operations. Quantifying these learning curves supports safer implementation and credentialing of the Versius robotic platform in colorectal cancer surgery.

Sachańbiński T, Miodoński M, Kropieniewicz J · International journal of colorectal disease · (2026) · View on PubMed ↗ · Free PDF ↗

Multidisciplinary approach in cardiac sarcoidosis: to biopsy or not?

This narrative review synthesized evidence on cardiac sarcoidosis diagnosis, focusing on whether endomyocardial biopsy (EMB) remains necessary within a multidisciplinary diagnostic framework. It emphasized that EMB has historically been considered a gold standard but has limited sensitivity with false negatives and procedural risks, driving increased reliance on noninvasive imaging. The review’s significance is guiding contemporary diagnostic pathways that balance tissue confirmation against modern imaging strategies for cardiac sarcoidosis.

Pericao A, Sharma R · Current opinion in pulmonary medicine · (2026) · View on PubMed ↗

A Global Consensus Conference on Surgical Management of Primary Uterovaginal Prolapse and Lower Urinary Tract Dysfunction: Combining Evidence with Expert Opinion.

This global consensus conference studied best-practice surgical management for primary uterovaginal prolapse (U-POP) and lower urinary tract dysfunction by combining systematic review evidence with expert opinion. The key output was a structured, committee-based synthesis of evidence and identification of unanswered questions to guide clinical decision-making and future research methodology. Its significance lies in standardizing guidance for controversial aspects of U-POP surgery and training junior researchers in systematic review/meta-analysis approaches.

Gupta A, Grimes CL, Badlani G et al. · International urogynecology journal · (2026) · View on PubMed ↗ · Free PDF ↗

FDG PET for cardiac sarcoidosis: Protocol optimization, quantification, pitfalls, and multimodality imaging integration.

This review studied how to optimize and interpret fluorodeoxyglucose (FDG) positron emission tomography (PET) for diagnosing and managing cardiac sarcoidosis (CS), focusing on protocol optimization, quantification, and common pitfalls. It summarizes multimodality integration with echocardiography and cardiac magnetic resonance (CMR) within a probabilistic framework and emphasizes PET’s role in clinical decision-making for CS. The article is significant because standardized FDG-PET approaches and awareness of pitfalls can improve diagnostic accuracy and risk stratification in a heterogeneous disease.

Wopperer SB, Kronzer E, Ivare J et al. · Seminars in nuclear medicine · (2026) · 1 citations · View on PubMed ↗

Polygenic Risk Identifies Older Adults Who May Benefit From Aspirin for the Primary Prevention of Ischemic Stroke.

This post hoc analysis studied whether an integrative polygenic score (iPGS) can identify older adults who may benefit from daily 100-mg aspirin for primary prevention of ischemic stroke within the ASPREE randomized, placebo-controlled trial. The key finding was that polygenic risk stratification could delineate a subgroup of participants in whom the net benefit of aspirin may outweigh bleeding risk, rather than applying aspirin uniformly to all older adults. This is significant because it advances precision prevention by using genome-wide variant–derived risk (iPGS from >1.2 million variants) to guide aspirin decisions in adults aged >70 years without prior cardiovascular disease.

Yu C, Hussain SM, Fransquet PD et al. · Stroke · (2026) · 1 citations · View on PubMed ↗

Non-cardiac clinical outcomes and public health

The burden of ovarian cancer attributable to occupational asbestos exposure in Asia from 1990 to 2021: an analysis of the global burden of disease study 2021.

This Global Burden of Disease 2021-based analysis quantified ovarian cancer burden attributable to occupational asbestos exposure across Asia from 1990 to 2021. The key finding is the regional magnitude and temporal trends of asbestos-attributable ovarian cancer outcomes (deaths and disability-adjusted life years) using age-standardized and crude rates. The scientific and public-health significance is that it informs occupational risk reduction policies and prioritization of prevention and surveillance in high-exposure Asian settings.

Yu Y, Zhang W, Deng T et al. · Tropical medicine and health · (2026) · View on PubMed ↗ · Free PDF ↗

Translation, cross-cultural adaptation, and psychometric evaluation of the Arabic version of the University of Wisconsin running injury and recovery index: a reliability and validity study.

This psychometric study translated and cross-culturally adapted the University of Wisconsin Running Injury and Recovery Index into Arabic (UWRI-Ar) and evaluated reliability and validity in Arabic-speaking runners with running-related injury. In 83 participants (with 49 completing retest after 2–5 days), the UWRI-Ar demonstrated acceptable measurement properties based on test-retest reliability and validity analyses. The validated Arabic instrument enables culturally appropriate assessment of running injury status and recovery for clinicians and researchers in Arabic-speaking populations.

Aljohani MMA, Alshehri YS, Shuwayhi AM et al. · BMC sports science, medicine & rehabilitation · (2026) · View on PubMed ↗ · Free PDF ↗

Zanubrutinib combined with R-CHOP in previously untreated diffuse large B-cell lymphoma with specific gene alteration: a phase II study.

This phase II trial studied zanubrutinib (a BTK inhibitor) combined with R-CHOP as frontline therapy in previously untreated diffuse large B-cell lymphoma (DLBCL) patients aged 18–75 years with high-risk molecular alterations. The key finding was the feasibility/efficacy assessment of this regimen in genomically defined high-risk disease characterized by alterations such as MYD88, CD79B, NOTCH1, TP53 mutations, or MYC rearrangements. If results are favorable, it would support a gene-guided escalation strategy using BTK inhibition to improve outcomes beyond standard R-CHOP in high-risk DLBCL.

Zhang Q, Jiang S, Wei R et al. · Blood cancer journal · (2026) · View on PubMed ↗ · Free PDF ↗

This study analyzed updated patient-reported health-related quality of life (HRQOL) and how disease progression affects HRQOL in patients with newly diagnosed advanced ovarian cancer enrolled in the PRIMA/ENGOT-OV26/GOG-3012 trial randomized to niraparib first-line maintenance versus placebo. Niraparib maintained HRQOL over time, and disease progression was associated with clinically meaningful worsening across multiple patient-reported instruments (including EORTC QLQ-C30/OV28, FOSI, and EQ-VAS). These findings support the clinical value of niraparib by demonstrating not only survival benefit but also preservation of patient-centered outcomes during first-line maintenance therapy.

Shahin MS, Lorusso D, Backes FJ et al. · Gynecologic oncology · (2026) · View on PubMed ↗

CAR-T Cell Therapy Versus Salvage Chemotherapy in Relapsed/Refractory DLBCL: A Systematic Review and Meta-Analysis Integrating Radiologic, Laboratory, and Histopathologic Correlates.

This systematic review and meta-analysis studied randomized trials and high-quality comparative cohort studies in adults with relapsed/refractory diffuse large B-cell lymphoma (R/R DLBCL) comparing CAR-T cell therapy versus salvage chemotherapy. The analysis integrated radiologic, laboratory, and histopathologic correlates to estimate comparative effectiveness across heterogeneous high-risk and primary refractory molecular contexts. The work is significant for informing treatment sequencing and expected outcomes when choosing between CAR-T and salvage chemotherapy in R/R DLBCL.

Elsayed FM, Baban J, Elkholy HY et al. · La Clinica terapeutica · (2026) · View on PubMed ↗

Autologous Stem Cell Transplantation Of HIV-Positive Plasmablastic Lymphoma - Case Series.

This case series studied HIV-positive patients with plasmablastic lymphoma (PBL) treated with autologous stem cell transplantation (ASCT) as consolidation at first complete response (CR1) in the era of highly active antiretroviral therapy (HAART). The report focuses on safety and efficacy outcomes of ASCT in a population historically excluded from intensive therapy due to opportunistic infection risk. Clinically, it suggests ASCT can be feasible in selected HIV-associated PBL patients, supporting individualized aggressive treatment when viral control and supportive care are optimized.

Giri Raja Pandiyan VM, Perumal Kalaiyarasi J, Govindarajan DD et al. · Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion · (2026) · View on PubMed ↗

A 12-week Exercise Intervention Among Older Adults With Chronic Coronary Syndrome: Changes and Associations of Movement Behaviors and Cardiovascular Risk Factors.

This 12-week exercise intervention study followed 35 older adults with chronic coronary syndrome (CCS) to assess changes in movement behaviors (via 7-day accelerometry), obesity markers, cardiorespiratory fitness (VO2peak), cardiometabolic risk, and brain-derived neurotrophic factor (BDNF). The study examined whether baseline-to-9-month changes in movement behaviors were associated with VO2peak, cardiometabolic risk, and BDNF. The findings are intended to clarify which behavioral activity patterns most strongly relate to cardiovascular fitness and biomarker improvement in CCS.

Ullrich A, Bahls M, Voigt L et al. · European journal of sport science · (2026) · View on PubMed ↗ · Free PDF ↗

Intentional self-harm mortality among 15-24 year olds in Asian American subgroups, 2005-2022: a population-based incidence study.

This population-based incidence study examined intentional self-harm mortality among U.S. youth aged 15–24 years across six Asian American subgroups (Asian Indian, Chinese, Filipino, Japanese, Korean, Vietnamese) from 2005–2022 using National Center for Health Statistics mortality data. The key finding was that suicide mortality rates differed by Asian American subgroup, indicating that overall Asian American estimates mask important within-group variation. The clinical/public health significance is improved surveillance and targeted prevention strategies for specific Asian American youth subpopulations using ICD-10 intentional self-harm codes (X60–X84, Y87.0).

Uy LA, Chang E, Desai S et al. · Lancet regional health. Americas · (2026) · View on PubMed ↗ · Free PDF ↗

Interpersonal Relationship, Academic Performance, & Life Skills: A Comparative Study of Children With and Without Emotional and Behavioral Problems.

This cross-sectional comparative study examined how emotional and behavioral problems (EBPs) relate to interpersonal relationships, academic performance, and life skills in children aged 6–14 years from West Bengal. The key finding was that children with EBPs scored significantly lower on interpersonal relationships and life skills compared with children without EBPs (with additional domain differences reported across standardized measures). The significance is that EBPs are associated with measurable functional impairments, supporting early identification and targeted psychosocial interventions in pediatric populations.

Kheto P, Pallerla S, Bhattacharjee K et al. · Clinical child psychology and psychiatry · (2026) · View on PubMed ↗

Construction and modification of a low-copy plasmid-based infectious clone for GI-19 genotype IBV via Red/ET recombineering: A simplified and efficient reverse genetics system for coronavirus.

This study constructed and modified a low-copy plasmid-based infectious clone for avian infectious bronchitis virus (IBV) GI-19 genotype using Red/ET recombineering to enable a streamlined reverse genetics workflow. The authors integrated low-copy plasmid vectors with RecE/RecT-mediated recombination plus positive/counter-selection to assemble multiple genome segments and rapidly screen recombinant viruses. This provides an efficient platform for precise genetic modification of IBV, accelerating functional studies and vaccine/attenuation research in poultry.

Feng K, Li Y, Song C et al. · Poultry science · (2026) · View on PubMed ↗ · Free PDF ↗

Generated automatically on July 05, 2026. Covers PubMed articles published June 28, 2026 – July 05, 2026. Summaries are AI-generated; always consult the original publication for clinical or research decisions.

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