What’s New in Cardiac MRI?

July 06, 2026 · 93 articles · 15 research themes · covering June 29, 2026 – July 06, 2026

Overview

Across this week’s set of studies, a dominant theme is the move from “single-number” cardiac imaging to richer, multimodal, and often quantitative phenotyping for risk prediction. Cardiac MRI biomarkers—especially extracellular volume (ECV) and other tissue-mapping metrics—repeatedly emerged as incremental prognostic tools in heterogeneous cardiomyopathies and systemic diseases (e.g., AL amyloidosis sudden death risk, ATTR-CA outcomes, and hypertrophic cardiomyopathy risk beyond LGE). Similarly, advanced CMR feature tracking (e.g., left atrial strain in atrial fibrillation) and multi-chamber strain approaches aim to detect dysfunction earlier than conventional static measures.

A second major thread is precision risk stratification for arrhythmia and adverse events using imaging-derived substrate and machine learning. Studies on ischemic and non-ischemic scar characterization (including LGE-CMR deep learning for arrhythmic death risk), microvascular obstruction after reperfused STEMI, and ventricular tachycardia ablation targeting emphasize that the “where” and “how” of myocardial injury matters for prognosis and treatment planning. Complementing this, several works highlight that clinical labels alone can be misleading—whether in MINOCA endotypes (e.g., coronary microembolization mechanisms), septic cardiomyopathy definitions, or Takotsubo phenotypes—supporting a shift toward mechanism- and tissue-informed classification.

Finally, the digest shows rapid methodological acceleration in cardiac imaging and analytics: radiomics of pericardial/epicardial fat, improved CMR acquisition/physics (cine optimization, magnetization-transfer-aware fingerprinting, low-field CMR), and computational approaches (4D flow/CFD modeling, federated learning for segmentation, and NLP for cardio-oncology EHR phenotyping). Together, these efforts point toward more scalable, standardized, and generalizable imaging workflows—while also revealing ongoing needs for harmonization (e.g., stress-test interpretation consistency, standardized data elements) and for careful validation before clinical translation.

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Cardiac MRI Radiomics & Adipose Tissue Biomarkers

Integrative Observational and Genetic Evidence From the UK Biobank Supports Carotid Intima-Media Thickness as a Window Into Cardiac Remodeling.

This UK Biobank integrative observational and genetic study tested whether carotid intima-media thickness (cIMT) reflects early cardiac remodeling and shares genetic determinants with cardiovascular disease. In 46,102 participants with carotid ultrasound and cardiac magnetic resonance imaging (excluding prevalent heart failure, atrial fibrillation, or stroke), it assessed multivariable phenotypic associations and genetic evidence linking cIMT to aortic and cardiac traits and subsequent cardiovascular outcomes. The findings are significant because they position cIMT as a noninvasive “window” into subclinical cardiac remodeling, potentially enabling earlier identification of individuals at risk for cardiovascular disease.

Chong SH, Saccoh AF, van Vugt M et al. · Journal of the American Heart Association · (2026) · View on PubMed ↗ · Free PDF ↗

Analysis of cardiac magnetic resonance characteristics in patients with ejection fraction preserved heart failure.

This retrospective CMR study evaluated epicardial adipose tissue (EAT) volume and its relationship to left ventricular function and outcomes in 117 patients with heart failure with preserved ejection fraction (HFpEF), compared with 65 healthy controls and 62 high-risk individuals, with additional follow-up in 228 participants. It found that CMR-measured EAT volume was associated with left ventricular strain and was used to assess prognosis for heart failure readmission or all-cause death. The clinical significance is that CMR quantification of EAT may provide a measurable imaging biomarker linking metabolic/inflammatory fat depots to HFpEF severity and risk stratification.

Zhang Y, Li Y, Yang X et al. · Clinical radiology · (2026) · View on PubMed ↗

Incremental Prognostic Value of Pericardial Adipose Tissue Radiomic Phenotype Based on Cardiac MRI in Patients With End-Stage Renal Disease.

This retrospective multicenter study evaluated whether radiomic features of pericardial adipose tissue (PEAT) from 3.0T cardiac MRI (including cine imaging plus T2/T2* mapping) predict major adverse cardiac events (MACE) in 248 end-stage renal disease (ESRD) patients. The key finding was that PEAT radiomic phenotypes provided incremental prognostic value for MACE beyond conventional PEAT volume, with performance validated in an independent cohort. This suggests that PEAT radiomics on cardiac MRI could improve risk stratification for cardiovascular outcomes in ESRD patients, potentially guiding closer surveillance or preventive strategies.

Zhang TY, Liu Y, Chen SZ et al. · Journal of magnetic resonance imaging : JMRI · (2026) · View on PubMed ↗

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Cardioprotection & Pharmacologic Trials in Cardiac Disease

Targeting Arrhythmogenic Late Sodium Current by FHF1A-Derivative FixR in Heart Failure Cardiomyocytes.

The study examined whether an engineered FHF1A-derivative peptide (FixR; FHF inhibiting x region) can suppress arrhythmogenic late Na+ current (INa,L) in human heart failure with reduced ejection fraction (HFrEF) cardiomyocytes and in translational HFrEF/HFpEF animal models, with expression profiling of cardiac Na+ channel and FHF splice isoforms by RT-qPCR. FixR targeted FGF homologous factors (FHF1-4) regulation of INa,L and reduced the proarrhythmogenic late sodium current implicated in heart failure. This provides a mechanism- and pathway-specific therapeutic strategy for INa,L–driven arrhythmia risk in heart failure beyond CaMKII-focused approaches.

Hegyi B, Angsutararux P, Chakouri N et al. · Circulation research · (2026) · 1 citations · View on PubMed ↗ · Free PDF ↗

Diagnostic Tests for Stage B Heart Failure.

This review synthesized guideline- and study-based evidence on diagnostic tests for Stage B heart failure (SBHF) in adults at risk for subclinical myocardial remodeling before symptom onset. It highlights transthoracic echocardiography—particularly speckle tracking echocardiography—as the cornerstone for detecting early myocardial dysfunction, with circulating biomarkers such as natriuretic peptides and high-sensitivity cardiac troponins providing complementary diagnostic information. Clinically, improving SBHF detection can enable earlier risk stratification and intervention to prevent progression to symptomatic heart failure.

Dang HNN, Luong TV, Huynh Q et al. · Current cardiology reports · (2026) · View on PubMed ↗ · Free PDF ↗

Cardiac Safety Outcomes in Delandistrogene Moxeparvovec Clinical Trials for Duchenne Muscular Dystrophy with Up to 5 Years of Follow-up.

This study assessed cardiac safety of the gene transfer therapy delandistrogene moxeparvovec (delivers functional dystrophin) in participants with Duchenne muscular dystrophy enrolled in trials 101 (NCT03375164), 102 (NCT03769116), ENDEAVOR (NCT04626674), and EMBARK (NCT05096221), with up to 5 years of follow-up and exclusion of baseline LVEF <40%. Across regularly collected adverse events, echocardiography, and serial troponin I measurements, the therapy showed cardiac safety outcomes consistent with preserved cardiac monitoring over extended follow-up in this LVEF-excluded DMD population. These findings support the ongoing clinical use and monitoring framework for delandistrogene moxeparvovec in DMD patients at relatively preserved baseline cardiac function.

Veerapandiyan A, Bourke J, Soslow JH et al. · Cardiology and therapy · (2026) · View on PubMed ↗ · Free PDF ↗

Cardiac magnetic resonance imaging assessment of Del Nido versus cold blood cardioplegia in patients with low ejection fraction undergoing combined coronary artery bypass graft and mitral valve replacement: Early outcomes.

This single-center prospective study compared Del Nido cardioplegia (DNC) versus conventional cold blood cardioplegia (CBC) in 42 patients with reduced left ventricular ejection fraction (LVEF <45%) undergoing concomitant coronary artery bypass grafting (CABG) and mitral valve replacement (MVR), using cardiac magnetic resonance imaging to assess early myocardial functional recovery. The key finding was the differential early myocardial functional recovery between the two cardioplegia strategies as quantified by CMR-derived measures in this high-risk low-EF surgical cohort. Scientifically and clinically, the study informs myocardial protection choices during combined CABG/MVR in patients with impaired baseline systolic function.

Gode S, Polat M, Eroğlu Polat A et al. · Turk gogus kalp damar cerrahisi dergisi · (2026) · View on PubMed ↗ · Free PDF ↗

Continuous Glucose Monitoring and Mortality Risk Among U.S. Veterans Receiving Dialysis With Diabetes.

This research examined whether continuous glucose monitoring (CGM) use versus non-CGM use is associated with mortality among U.S. veterans receiving dialysis who also have diabetes, using linked national Veterans Affairs, U.S. Renal Data System, and Medicare data. The key finding was the association between CGM use and survival outcomes in this high-risk dialysis population with diabetes (i.e., CGM status was evaluated as a prognostic factor rather than relying on conventional glycemic markers). Clinically, if CGM is linked to improved survival, it would support broader CGM adoption in dialysis patients where traditional glycemic measures are less accurate and less actionable.

Narasaki Y, Kalantar-Zadeh K, Zisman-Ilani Y et al. · Diabetes care · (2026) · View on PubMed ↗ · Free PDF ↗

Atorvastatin and left ventricular strain during anthracycline-based chemotherapy.

In the randomized STOP-CA trial of lymphoma patients receiving anthracycline-based chemotherapy, investigators tested whether atorvastatin (12 months) attenuates declines in left ventricular strain measured by cardiac MRI feature tracking (FT) global longitudinal strain (GLS) and global circumferential strain (GCS). The key finding was that atorvastatin did not meaningfully prevent or reduce anthracycline-associated deterioration in GLS and GCS compared with placebo at 12 months. Clinically, this indicates that atorvastatin may not be an effective cardioprotective strategy for preserving MRI-derived LV deformation during anthracycline therapy.

Juhasz V, Quinaglia T, Drobni ZD et al. · International journal of cardiology · (2026) · 1 citations · View on PubMed ↗ · Free PDF ↗

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Sex Differences in Valvular Heart Disease & Transcatheter Care

Sex-based differences in mitral and tricuspid valve disease in the era of transcatheter therapies: a contemporary review.

This contemporary review synthesized evidence on sex-based differences in mitral and tricuspid valve disease, focusing on how sex influences epidemiology, pathophysiology, imaging assessment, and management in the era of transcatheter therapies. The key finding was that women and men show distinct patterns of valve disease presentation and diagnostic/procedural considerations that can affect outcomes as transcatheter interventions expand. Scientifically and clinically, the review supports incorporating sex-specific evaluation into imaging and treatment planning for mitral and tricuspid transcatheter care.

Oletu H, Irivbogbe OA, Akhtar Y · Current problems in cardiology · (2026) · View on PubMed ↗

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Cardiac Sarcoidosis: Biopsy, PET, and Multimodality Diagnosis

Multidisciplinary approach in cardiac sarcoidosis: to biopsy or not?

This review evaluated the diagnostic role of endomyocardial biopsy (EMB) in patients with cardiac sarcoidosis, within a multidisciplinary framework that also uses noninvasive imaging. It found that EMB’s historically “gold standard” status is limited by low sensitivity, false-negative/inconclusive results, and procedural risks, driving greater reliance on modern imaging-based strategies. Clinically, this supports a more selective, tissue-informed approach rather than routine EMB for all suspected cardiac sarcoidosis cases.

Pericao A, Sharma R · Current opinion in pulmonary medicine · (2026) · View on PubMed ↗

FDG PET for cardiac sarcoidosis: Protocol optimization, quantification, pitfalls, and multimodality imaging integration.

This 2026 review studied how to optimize and quantify 18F-FDG PET for diagnosing and managing cardiac sarcoidosis, integrating PET with echocardiography and cardiac MRI across clinical workflows. It found that careful protocol choices (including dietary preparation and attention to known pitfalls) improve interpretability of PET inflammation signals and that multimodality imaging can refine diagnostic probability and treatment decisions. The review’s significance is that standardized PET approaches and multimodality integration can reduce misclassification and better guide therapy in a heterogeneous disease with major risks such as heart failure, conduction disease, ventricular arrhythmias, and sudden death.

Wopperer SB, Kronzer E, Ivare J et al. · Seminars in nuclear medicine · (2026) · 1 citations · View on PubMed ↗

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Mitral Regurgitation & Patient Selection for M-TEER

An integrative approach to patient selection for mitral transcatheter edge-to-edge repair in secondary mitral regurgitation.

This review studied how to select patients with secondary mitral regurgitation (SMR) for mitral transcatheter edge-to-edge repair (M-TEER), integrating evidence from randomized trials (notably MITRA-FR and COAPT) and multimodality echocardiography. It concluded that differences in echocardiographic selection and left-ventricular remodeling largely explain the divergent trial outcomes, implying SMR severity should be interpreted relative to ventricular size and regurgitant context. Scientifically and clinically, the proposed structured selection framework aims to improve which SMR patients derive benefit from M-TEER.

Brusosa M, Flores-Umanzor E, Horlick E · Current opinion in cardiology · (2026) · View on PubMed ↗

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Standardization & Data Harmonization (Clinical Data Elements)

Learning curves in Versius-assisted colorectal surgery: a risk-adjusted CUSUM analysis from a single center.

This retrospective single-center study evaluated procedure- and operator-specific learning curves for Versius-assisted colorectal cancer surgery in consecutive adult patients undergoing elective robotic procedures between December 2022 and August 2025. Using risk-adjusted CUSUM (RA-CUSUM) analysis of skin-to-skin operative time for right hemicolectomy, sigmoid resection, and anterior rectal resection, it assessed how performance improved over time while adjusting for patient- and procedure-specific variables. The findings are significant for training and credentialing, helping quantify when surgeons and teams achieve proficiency with the Versius robotic platform.

Sachańbiński T, Miodoński M, Kropieniewicz J · International journal of colorectal disease · (2026) · View on PubMed ↗ · Free PDF ↗

A Global Consensus Conference on Surgical Management of Primary Uterovaginal Prolapse and Lower Urinary Tract Dysfunction: Combining Evidence with Expert Opinion.

This global consensus conference studied best-practice surgical management for primary uterovaginal prolapse (U-POP) and associated lower urinary tract dysfunction by combining systematic evidence review with expert opinion. Using geographically diverse committees and a MEDLINE/Embase/ClinicalTrials.gov search (2000–Dec 2025) with committee-specific questions, it aimed to define controversial aspects of surgery and identify unanswered research questions. The significance is that it provides an evidence-informed, standardized framework to guide clinical decision-making and future research in U-POP surgery.

Gupta A, Grimes CL, Badlani G et al. · International urogynecology journal · (2026) · View on PubMed ↗ · Free PDF ↗

Stroke and its consequences: protocol and pilot data of the observational Berlin Long-term Observation of Vascular Events (BeLOVE) stroke stratum.

This protocol and pilot study examined long-term outcomes after stroke using the Berlin Long-term Observation of Vascular Events (BeLOVE) stroke stratum in adult patients with acute ischemic stroke, transient ischemic attack (TIA), or non-traumatic intracerebral hemorrhage. The key finding is the establishment of a prospective, longitudinal, hospital-based cohort design intended to quantify major adverse cerebro- and cardiovascular events and death (MACE) as well as cognitive, mental, and patient-reported outcomes over the long term. This is scientifically significant because it provides a structured framework to generate evidence on outcomes that are currently poorly understood after different stroke subtypes.

Nolte CH, Weber JE, Ahmadi M et al. · BMJ neurology open · (2026) · View on PubMed ↗

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Patient-Reported Outcomes & Psychometrics in Health/Exercise

The burden of ovarian cancer attributable to occupational asbestos exposure in Asia from 1990 to 2021: an analysis of the global burden of disease study 2021.

This Global Burden of Disease 2021–based analysis quantified ovarian cancer (OC) deaths and disability-adjusted life years (DALYs) attributable to occupational asbestos exposure across Asian countries from 1990 to 2021. The study characterized the regional burden and temporal trends of age-standardized and crude OC rates linked to occupational asbestos exposure. These findings are important for public health planning and occupational risk mitigation by identifying where asbestos-related OC burden is greatest and how it has changed over time.

Yu Y, Zhang W, Deng T et al. · Tropical medicine and health · (2026) · View on PubMed ↗ · Free PDF ↗

Translation, cross-cultural adaptation, and psychometric evaluation of the Arabic version of the University of Wisconsin running injury and recovery index: a reliability and validity study.

This study translated and cross-culturally adapted the University of Wisconsin Running Injury and Recovery Index (UWRI) into Arabic (UWRI-Ar) and evaluated its psychometric performance in Arabic-speaking runners aged 18–45 years with running-related injury. In 83 participants (with 49 completing test-retest after 2–5 days), the UWRI-Ar demonstrated acceptable reliability and validity properties for measuring running injury and recovery. The clinical significance is that Arabic-speaking clinicians and researchers can use a validated instrument to assess injury status and recovery in this population.

Aljohani MMA, Alshehri YS, Shuwayhi AM et al. · BMC sports science, medicine & rehabilitation · (2026) · View on PubMed ↗ · Free PDF ↗

Updated patient-reported outcomes and the effect of disease progression on health-related quality of life in the PRIMA/ENGOT-OV26/GOG-3012 trial of niraparib first-line maintenance therapy in patients with newly diagnosed advanced ovarian cancer.

This analysis studied updated patient-reported outcomes (PROs) and the effect of disease progression on health-related quality of life in patients with newly diagnosed advanced ovarian cancer enrolled in the PRIMA/ENGOT-OV26/GOG-3012 trial. The key finding was that patients were randomized 2:1 to niraparib first-line maintenance versus placebo, with longitudinal HRQOL assessed using EORTC QLQ-C30 and QLQ-OV28, FOSI, and EQ-5D-5L (EQ-VAS), and that disease progression influenced HRQOL trajectories. This is clinically significant because it quantifies the patient-centered quality-of-life impact of niraparib maintenance in real-world decision-making beyond traditional efficacy endpoints.

Shahin MS, Lorusso D, Backes FJ et al. · Gynecologic oncology · (2026) · View on PubMed ↗

A 12-week Exercise Intervention Among Older Adults With Chronic Coronary Syndrome: Changes and Associations of Movement Behaviors and Cardiovascular Risk Factors.

This 12-week group exercise intervention study enrolled 35 older adults with chronic coronary syndrome (CCS) and assessed changes in movement behaviors (via 7-day accelerometry), obesity markers, cardiorespiratory fitness (VO2peak), cardiometabolic risk, and brain-derived neurotrophic factor (BDNF) at baseline and follow-up (including 9 months). The key finding was that improvements in movement behaviors were associated with changes in VO2peak, cardiometabolic risk, and BDNF over time. Clinically, it reinforces exercise as a modifiable strategy in CCS and suggests that activity patterns may mediate both fitness and cardiometabolic/neurometabolic benefits.

Ullrich A, Bahls M, Voigt L et al. · European journal of sport science · (2026) · View on PubMed ↗ · Free PDF ↗

Polygenic Risk Identifies Older Adults Who May Benefit From Aspirin for the Primary Prevention of Ischemic Stroke.

This post hoc analysis studied whether an integrative polygenic score (iPGS) can identify older adults who may benefit from daily 100 mg aspirin for primary prevention of ischemic stroke, using data from the ASPREE randomized trial. Among 12,031 genotyped European-ancestry participants aged >70 years without prior cardiovascular disease, the iPGS stratified risk such that a subset with higher predicted benefit could potentially derive net ischemic-stroke benefit despite bleeding concerns. The clinical significance is that polygenic risk stratification could personalize aspirin decisions in older adults rather than applying uniform recommendations.

Yu C, Hussain SM, Fransquet PD et al. · Stroke · (2026) · 1 citations · View on PubMed ↗

Intentional self-harm mortality among 15-24 year olds in Asian American subgroups, 2005-2022: a population-based incidence study.

This population-based incidence study analyzed National Center for Health Statistics mortality data (2005–2022) for U.S. youth aged 15–24 years, disaggregating intentional self-harm deaths (ICD-10 X60–X84, Y87.0) across six Asian American subgroups (Asian Indian, Chinese, Filipino, Japanese, Korean, Vietnamese) using American Community Survey denominators. The study found differences in intentional self-harm mortality across these Asian American subgroups compared with non-Hispanic White and an overall Asian youth comparison group. These subgroup-specific surveillance results can improve targeting of suicide prevention and public health monitoring for Asian American youth at highest risk.

Uy LA, Chang E, Desai S et al. · Lancet regional health. Americas · (2026) · View on PubMed ↗ · Free PDF ↗

Interpersonal Relationship, Academic Performance, & Life Skills: A Comparative Study of Children With and Without Emotional and Behavioral Problems.

This cross-sectional comparative study examined 120 children aged 6–14 years in West Bengal, India, stratified by presence versus absence of emotional and behavioral problems (EBPs), using standardized scales including the Pediatric Symptom Checklist (PSC), Child Interpersonal Relationships and Attitudes Assessment (CIRAA), Academic Performance Scale (APS), and Life Skills Assessment Scale (LSAS). Children with EBPs scored significantly lower on interpersonal relationships and life skills compared with children without EBPs. The findings support screening for EBPs as a way to identify children at risk for broader functional impairments in school and daily life.

Kheto P, Pallerla S, Bhattacharjee K et al. · Clinical child psychology and psychiatry · (2026) · View on PubMed ↗

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Heart Failure Therapies & Implementation (Polypills, GDMT)

Polypill for heart failure with reduced ejection fraction: the POLY-HF randomized trial.

This open-label randomized POLY-HF trial studied whether a once-daily heart failure with reduced ejection fraction (HFrEF) polypill improves cardiac function in adults with left ventricular ejection fraction ≤40%, enrolling a predominantly underserved population at two centers. Participants received either the polypill containing metoprolol succinate (25/50/100/150 mg), spironolactone 12.5 mg, and empagliflozin 10 mg or rapid uptitration of individual guideline-directed medical therapy drugs. The significance is that a fixed-dose polypill strategy could improve real-world implementation of guideline-directed therapy and thereby outcomes in HFrEF.

Pandey A, Keshvani N, Rizvi SK et al. · Nature medicine · (2026) · View on PubMed ↗

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Coronary Microvascular Dysfunction & MINOCA Endotypes

Molecular mechanisms of coronary microembolization-induced MINOCA.

The article reviewed and investigated the molecular mechanisms by which coronary microembolization (CME) can cause myocardial infarction with non-obstructive coronary arteries (MINOCA), focusing on why diagnosis is often delayed because CMR is typically performed days after the index event. It emphasized that CME is a major underlying pathology in MINOCA but that the specific molecular pathways remain insufficiently defined, limiting rapid diagnostics and targeted treatment. Clarifying CME molecular mechanisms could enable earlier MINOCA diagnosis and development of mechanism-based therapies.

Iske J, Thau H, Mesfin JM et al. · Basic research in cardiology · (2026) · View on PubMed ↗ · Free PDF ↗

Stratified Medicine with Eplerenone for Myocardial Infarction or Injury and No obstructive Coronary Arteries: A Registry-Based Basket Trial.

This registry-based basket trial studied patients with myocardial infarction with no obstructive coronary arteries (MINOCA) or nonischemic myocardial injury to determine the prevalence and prognostic/treatment relevance of coronary microvascular dysfunction and to test endotype-informed therapy. It planned stratified treatment with the mineralocorticoid receptor antagonist eplerenone for patients identified as having coronary microvascular dysfunction. Scientifically, the trial targets a precision-medicine approach for MINOCA/MINOCA-like syndromes where evidence-based therapies are currently limited.

Sykes R, Tan D, McKinley G et al. · American heart journal · (2026) · View on PubMed ↗ · Free PDF ↗

Stress native mapping does not distinguish patients with previous myocardial infarction with non-obstructive coronary arteries from healthy volunteers.

This study tested whether stress native T1 and T2 mapping (non-contrast, adenosine stress) can distinguish patients with previous myocardial infarction with non-obstructive coronary arteries (MINOCA) from healthy volunteers. In patients with MINOCA but normal CMR (n=15) compared with matched controls, the key finding was that stress native mapping did not show discriminative differences, despite the hypothesis of coronary microvascular dysfunction with reduced stress perfusion. Scientifically and clinically, it suggests that native T1/T2 stress mapping may be insufficient for identifying prior MINOCA in the presence of a normal CMR, guiding selection of more sensitive diagnostic approaches.

Andersson DF, Johansson RS, Tornvall P et al. · Clinical physiology and functional imaging · (2026) · View on PubMed ↗ · Free PDF ↗

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Ventricular Tachycardia Substrate Mapping & Ablation Risk

Revisiting the Link Between Substrate and Ventricular Tachycardia Rate: The Critical Role of Conduction Isthmus Structure and Function.

This prospective cohort study examined how substrate features relate to ventricular tachycardia (VT) rate in 62 patients undergoing ablation for scar-related VT. Using high-density electroanatomical mapping and late gadolinium-enhanced cardiac magnetic resonance, it compared global substrate metrics (e.g., total activation time and deceleration zone measures) versus isthmus-specific conduction isthmus structure/function features for predicting VT rate. The significance is that identifying conduction-isthmus properties may improve risk stratification and ablation targeting beyond global scar metrics.

Guichard JB, Castrillo-Golvano L, Molero-Pereira S et al. · Heart rhythm · (2026) · View on PubMed ↗ · Free PDF ↗

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Computational/AI Methods for Cardiac Imaging & Modeling

A Physiologic Left Ventricle Flow Phantom for 4D Flow MRI Applications and CFD Verification.

The study developed a subject-specific, MRI-compatible left ventricle (LV) flow phantom using a PVA-based hydrogel in a closed-loop circulation system to reproduce cardiac motion for 4D flow MRI and CFD verification. The phantom was designed to provide robust, repeatable end-diastolic and end-systolic geometries while maintaining MRI contrast and long-term leakage-free operation. This enables more reliable in vitro validation of cardiac MRI and computational fluid dynamics models without the motion artifacts and scan-time constraints of in vivo testing.

Wiegand M, Obermeier L, Dillinger H et al. · Annals of biomedical engineering · (2026) · View on PubMed ↗ · Free PDF ↗

Integrative network and structural analysis of Pinus derived phytosterols in diabetes associated pathways.

This in silico pharmacology study used an integrative computational workflow to evaluate how two Pinus-derived phytosterols, β-sitosterol and 24-nor-cholest-5,22E-dien-3β-ol, interact with endocrine-related protein targets implicated in diabetes. Network pharmacology identified ESR1, AR, SHBG, and CYP17A1 as central nodes in diabetes-associated pathways related to endocrine resistance. Scientifically, these predicted target interactions suggest mechanistic hypotheses for how Pinus phytosterols might modulate diabetes-relevant endocrine pathways, warranting experimental validation.

Ali PR, Sri GK, Sravanthi G et al. · In silico pharmacology · (2026) · View on PubMed ↗

Strategies for resilient climate in smart cities mediated by Nash equilibrium and autonomous decision-makers.

This paper studied decision-making frameworks for resilient climate in smart cities by integrating Nash equilibrium, autonomous multi-agent systems, and machine learning. It modeled each city as an autonomous agent that selects policies for pollution and climate-warming risk management to mitigate global warming effects. The significance is a computational approach that could help tailor climate policies to city-specific conditions using game-theoretic and data-driven methods.

Latha CM, Alvarado-Mentado M · Journal of environmental management · (2026) · View on PubMed ↗

Transforming Cardiac Imaging With Artificial Intelligence: Automation, Precision, and Clinical Integration in Echocardiography and Magnetic Resonance Imaging.

This narrative review studied artificial intelligence (AI) applications in cardiac imaging, specifically echocardiography and cardiac magnetic resonance (CMR), across 22 peer-reviewed studies from 2020–2026. It found that AI can automate image acquisition, segmentation of chambers and valves, and left ventricular ejection fraction measurement with accuracy comparable to experienced echocardiographers while reducing interobserver variability and analysis time, including improved detection of subclinical myocardial dysfunction via automated global longitudinal strain. This is clinically significant because it supports the translation of AI-driven imaging workflows into routine practice for more consistent and efficient cardiac assessment.

Choker AH · Echocardiography (Mount Kisco, N.Y.) · (2026) · View on PubMed ↗

Prediction of hypertension and restenosis under guideline-directed management in aortic coarctation: development and validation of machine-learning models.

This development-and-validation study examined machine-learning models to predict hypertension and restenosis in patients with aortic coarctation (CoA) under guideline-directed management, using routinely collected electronic health records and cardiovascular magnetic resonance (CMR) data from 160 individuals (218 visits) in Berlin, Germany. The key finding was that ML approaches (e.g., CatBoost, XGBoost, random forest, support vector classifiers, neural networks) were developed and validated to forecast long-term outcomes such as hypertension and restenosis despite recurrence occurring in up to one-third of patients. This is clinically significant because it aims to enable more individualized surveillance and risk stratification after CoA treatment using objective imaging and longitudinal clinical data.

Fierley L, Versnjak J, Gabel G et al. · EClinicalMedicine · (2026) · View on PubMed ↗ · Free PDF ↗

One Anatomy, Multiple Valve Choices: Interobserver Agreement in Selecting Transcatheter Pulmonary Valve.

This study examined interobserver agreement in selecting transcatheter pulmonary valve (TPVR) device type, size, and position using 3D patient-specific anatomies derived from cardiac magnetic resonance (CMR). The key finding was that six experienced observers from three regions independently assessed 60 reconstructed anatomies (pediatric and adult) and the study quantified agreement to evaluate how anatomical variability affects procedural planning. This is significant because it informs standardization and reliability of TPVR planning across centers, potentially improving consistency of device selection.

Pérez-Cualtán CE, Cabrales J, Garay F et al. · Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions · (2026) · View on PubMed ↗ · Free PDF ↗

Computational modeling of left ventricular flow using PC-CMR-derived four-dimensional wall motion.

This computational modeling study developed individualized left ventricular (LV) hemodynamic simulations by integrating two magnetic resonance imaging (MRI) modalities that quantify LV wall motion with computational fluid dynamics (CFD) to model LV flow. The key finding was that PC-CMR-derived four-dimensional wall motion can be used to drive patient-specific LV flow simulations, enabling feasible characterization of intracardiac hemodynamics without fully coupled fluid–solid modeling. This advances scientific capability for personalized assessment of LV hemodynamics and may support future imaging-driven risk prediction for cardiac disease.

Peighambari SB, Mukherjee T, Mendiola EA et al. · International journal of engineering science · (2026) · View on PubMed ↗

Leveraging natural language processing artificial intelligence for automated data extraction of ejection fraction and strain from cardiovascular imaging reports.

This retrospective observational study applied natural language processing (NLP) to multi-modality cardiovascular imaging reports from cancer survivors (over 4,000 patients) in a large academic medical center with electronic health records from 2000–2020, aiming to extract ejection fraction (EF) and related strain/functional parameters from echocardiography, nuclear cardiology, and cardiac magnetic resonance (CMR). The key finding was that NLP was feasible for automated extraction of EF and related cardiac imaging measurements across different imaging modalities over the 20-year record span. This supports scalable, EHR-based phenotyping for longitudinal cardio-oncology research where manual EF/strain abstraction is labor-intensive.

Brown SA, BagheriMohamadiPour M, Sparapani R et al. · American heart journal plus : cardiology research and practice · (2026) · View on PubMed ↗ · Free PDF ↗

In vivo evidence of blood flow slippage: failure of the no-slip boundary condition assumption.

This study used four-dimensional flow cardiovascular magnetic resonance (4D-flow CMR) in seven healthy adult volunteers, combined with Navier–Stokes data assimilation modeling of the descending thoracic aorta, to test whether the in vivo “no-slip” boundary condition holds for blood near the vessel wall. The key finding was evidence of “blood flow slippage,” with measured tangential wall velocities on the order of ~30–80% of the relevant near-wall velocity scale, implying violation of strict no-slip behavior. Scientifically, this challenges a foundational assumption in cardiovascular fluid dynamics and may improve the realism of computational models used for hemodynamic risk and device studies.

Jarolímová A, Hron J, Tůma K et al. · American journal of physiology. Heart and circulatory physiology · (2026) · View on PubMed ↗

Fetal MRI for cardiopulmonary anomalies: what the pediatric cardiologist and surgeon need to know.

This narrative review evaluated the role of fetal cardiac magnetic resonance imaging (CMR) as an adjunct to expert fetal echocardiography for prenatal assessment of complex cardiopulmonary anomalies. It reports that fetal CMR can provide high-resolution, multiplanar, wide field-of-view imaging with superior soft-tissue contrast, improving diagnostic and prognostic information when echocardiography is limited by technical/physiologic factors and thereby informing counseling, delivery planning, and postnatal management. Clinically, integrating fetal CMR into fetal cardiology workflows can reduce uncertainty and improve care planning for fetuses with complex heart and thoracic pathology.

Dadoun SE, Mokha S, Kooraki S et al. · Current opinion in cardiology · (2026) · View on PubMed ↗

FedSemiDG: Domain generalized federated semi-supervised medical image segmentation.

This study proposed FedSemiDG, a domain generalized federated semi-supervised learning framework for medical image segmentation that targets domain shift across centers in federated semi-supervised learning. The key finding is that explicitly modeling domain generalization in federated semi-supervised training can mitigate suboptimal aggregation and improve performance on unseen domains compared with standard federated semi-supervised approaches. Scientifically, FedSemiDG advances federated segmentation methods toward more robust deployment across heterogeneous imaging sites.

Deng Z, Xu Z, Isshiki T et al. · Medical image analysis · (2026) · View on PubMed ↗

Large Language Models for Cardiac MRI Diagnosis Based on Standardized Text Descriptions.

This retrospective study evaluated large language models (LLMs) for cardiac MRI diagnosis using standardized text descriptions across a cohort including hypertrophic cardiomyopathy (n=203), dilated cardiomyopathy (n=186), hypertensive heart disease (n=46), ischemic cardiomyopathy (n=198), constrictive pericarditis (n=38), cardiac amyloidosis (n=45), myocarditis (n=91), and normal controls (n=144). The study found that LLM-based interpretation of standardized descriptions could support cardiac MRI diagnostic classification across these conditions. If validated prospectively, this approach could help less experienced centers by translating structured imaging information into diagnostic outputs.

Zhang H, Zhou J, Zhang C et al. · Journal of magnetic resonance imaging : JMRI · (2026) · View on PubMed ↗

Construction and modification of a low-copy plasmid-based infectious clone for GI-19 genotype IBV via Red/ET recombineering: A simplified and efficient reverse genetics system for coronavirus.

This study developed and optimized a low-copy plasmid-based infectious clone reverse genetics system for avian infectious bronchitis virus (IBV) GI-19 genotype IBV using Red/ET recombineering with positive and counter-selection steps. The key technical advance was a simplified one-step assembly of multiple genome segments via RecE/RecT-mediated recombination using p15A-Cm vectors, enabling efficient genome cDNA assembly, precise genetic modification, and rapid screening of recombinant viruses. This platform accelerates coronavirus reverse genetics in poultry by making it easier to generate and study IBV mutants for research and vaccine-related applications.

Feng K, Li Y, Song C et al. · Poultry science · (2026) · View on PubMed ↗ · Free PDF ↗

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Cardiac Tissue Quantification (T1/T2/ECV, Iron, Diffusion, CMR Physics)

Cardiac Imaging Predictors of Ventricular Recovery in Pediatric Patients Undergoing Aortic Valve Intervention for Regurgitation.

This retrospective study investigated preoperative echocardiogram and cardiac magnetic resonance (CMR) predictors of postoperative left ventricular (LV) recovery in pediatric and young adult patients (<30 years) undergoing aortic valve surgery for chronic aortic regurgitation (AR). It focused on identifying imaging parameters associated with LV reverse remodeling and functional recovery after intervention. Clinically, the findings aim to refine timing and risk assessment for AR surgery in younger patients where adult-derived thresholds may not apply.

Flerlage EK, Huma LC, Gandhi R et al. · Pediatric cardiology · (2026) · View on PubMed ↗

A Comparison of Tissue Property Values Estimated Using Conventional Cardiac MRF and MT-Cardiac MRF.

This work evaluated whether explicitly modeling magnetization transfer (MT) during reconstruction of cardiac magnetic resonance fingerprinting (cMRF) improves T1 and T2 quantification by comparing conventional cMRF (ignoring MT) with MT-cMRF (modeling free-water T1f/T2f and bound pool fraction BPF). In simulations, phantom experiments, and in 14 healthy subjects, MT-cMRF enabled accurate estimation of T1f, T2f, and BPF and improved tissue property estimation compared with conventional cMRF. The scientific significance is that MT-aware cMRF can better separate free and bound water contributions, potentially enhancing quantitative cardiac tissue characterization in future clinical studies.

Kaplan S, Liu Z, Hamilton J et al. · Magnetic resonance in medicine · (2026) · View on PubMed ↗ · Free PDF ↗

The importance of spatial resolution in detecting chronic myocardial iron remnants following hemorrhagic myocardial infarction with T2* MRI.

This study investigated how T2* cardiac MRI spatial resolution affects detection of chronic myocardial iron remnants after hemorrhagic myocardial infarction (hMI) using digital phantom simulations across voxel sizes and signal-to-noise ratio (SNR) levels, and ex-vivo swine hearts (n=10) with 8-week hMI. The key finding was that detection performance for chronic iron deposits depends strongly on spatial resolution (in-plane voxel size and slice thickness), with coarser resolution reducing sensitivity/accuracy. Scientifically, it provides practical imaging guidance for optimizing T2* protocols to reliably quantify post-hMI iron and potentially improve risk stratification.

Zhang X, Yang HJ, Dharmakumar R · Biomedical physics & engineering express · (2026) · View on PubMed ↗ · Free PDF ↗

Cardiac MRI Identifies Subclinical Myocardial Tissue Abnormalities in Individuals With Hepatitis C Regardless of Myocardial Damage Markers or Fibrosis Stage.

This study used 3T cardiac magnetic resonance (CMR) to measure cardiac extracellular volume (ECV) fraction in 10 untreated individuals with chronic hepatitis C virus (HCV) infection and compared results with age-matched healthy volunteers. The key finding was that HCV-infected participants had significantly higher ECV (0.30±0.03 vs 0.26±0.03) indicating inflammation/fibrosis-like tissue changes, independent of myocardial damage markers and fibrosis stage. Clinically, it supports early extrahepatic cardiac involvement in untreated HCV and strengthens the rationale for prompt HCV treatment to reduce downstream cardiovascular risk.

D’Amore A, Sirajuddin A, George N et al. · Journal of viral hepatitis · (2026) · View on PubMed ↗

Sustainable Low-Field Cardiovascular Magnetic Resonance in Changing Healthcare Systems-An Update.

This article reviewed advances enabling sustainable low-field cardiovascular magnetic resonance (LF-CMR), particularly around 0.55 Tesla, for assessing cardiac structure, function, and myocardial tissue characteristics in settings with constrained healthcare infrastructure, including low- and middle-income countries (LMICs). The key finding was that optimized hardware (e.g., gradient coils and radiofrequency systems) and AI-driven image reconstruction can preserve strong diagnostic performance despite lower signal-to-noise ratios. This is significant because it outlines a practical pathway to expand CMR access and reduce cost/complexity barriers while maintaining diagnostic utility.

Umair M, Marey A, Murali S et al. · NMR in biomedicine · (2026) · View on PubMed ↗ · Free PDF ↗

Simultaneous multi-slice Cardiac Diffusion Tensor Imaging with variable CAIPIRINHA shifts and artefact-aware AI.

This methodological study developed ORCAS, a simultaneous multi-slice (SMS) cardiac diffusion tensor imaging (cDTI) framework using variable CAIPIRINHA shifts and artefact-aware AI reconstruction to reduce acquisition time while maintaining signal quality. It found that the variable CAIPIRINHA strategy helps decohere SMS leakage artefacts across repetitions, and the AI reconstruction mitigates remaining artefact and noise limitations. The significance is faster in-vivo mapping of myocardial microstructure with cDTI, potentially making diffusion tensor biomarkers more feasible for routine cardiac imaging.

Tänzer M, Lim EJ, Qiu HH et al. · Medical image analysis · (2026) · View on PubMed ↗ · Free PDF ↗

Optimizing Cine Cardiac MRI: Technical Advances and Clinical Applications.

This article reviewed technical advances for cine cardiac MRI, focusing on optimizing pulse sequence parameters (TR, TE, flip angle, bandwidth) typically used with balanced steady-state free precession (bSSFP) to improve signal-to-noise ratio and temporal resolution. It emphasizes that performance is constrained by off-resonance effects, specific absorption rate (SAR) limits, and susceptibility artifacts—especially at ≥3T scanners. These optimization strategies can improve image quality and reliability of cine MRI for clinical cardiac function assessment.

Dehghani S, Rajabi A, Rahmati A et al. · Journal of magnetic resonance imaging : JMRI · (2026) · View on PubMed ↗

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Cardiac Imaging for Ischemia/Viability & Stress Testing Consistency

Fully quantitative CMR rest perfusion reveals myocardial perfusion abnormality in Kawasaki disease: Association with left ventricular Remodeling.

This prospective single-center study evaluated fully quantitative CMR rest perfusion in children with Kawasaki disease (KD) (n=87; mean age 7.5±2.2 years) to map myocardial perfusion abnormalities and relate them to left ventricular (LV) remodeling. Using myocardial blood flow (MBF) corrected for heart rate–blood pressure product (MBFcor), the study found perfusion abnormalities in KD and identified associations with subsequent LV remodeling measures. These findings support quantitative CMR perfusion as a tool for characterizing myocardial injury distribution and predicting remodeling risk in pediatric KD.

Zhou Z, Ye P, Wang C et al. · International journal of cardiology · (2026) · View on PubMed ↗

Characteristics and outcomes of patients undergoing coronary computed tomography angiography for suspected acute coronary syndrome in the emergency department.

This retrospective emergency-department study characterized outcomes of 198 consecutive patients with suspected acute coronary syndrome (ACS) who underwent coronary computed tomography angiography (CCTA) after cardiology assessment. The primary endpoint was a composite of major adverse cardiovascular events (MACE) including all-cause death, acute myocardial infarction, or myocardial revascularization, and the study reported the cohort’s event rates and clinical characteristics. The results inform how CCTA-based evaluation in the ED performs for risk assessment and downstream outcomes in suspected ACS.

Ciliberti G, Compagnucci P, Finori L et al. · The international journal of cardiovascular imaging · (2026) · View on PubMed ↗

Diagnostic and Prognostic Utility of Mitral Annular Plane Systolic Excursion: A Systematic Review and Meta-Analysis.

This systematic review and meta-analysis evaluated the diagnostic and prognostic utility of mitral annular plane systolic excursion (MAPSE) across studies using echocardiography and other imaging modalities. It focused on MAPSE as a fast, simple measure of longitudinal left ventricular function that can be obtained by transthoracic echocardiography (and also compared with CMR, transesophageal echo, and cardiac CT). The significance is that MAPSE could support earlier detection of cardiac dysfunction and improve prognostication, potentially informing future guideline recommendations for routine use.

Falconer D, Fröjdh F, Wyeth N et al. · Journal of the American Heart Association · (2026) · View on PubMed ↗ · Free PDF ↗

Variability in Cardiac Stress Test Interpretation: Agreement Between Enrollment Sites and Core Laboratories in the Global ISCHEMIA Trial.

This analysis studied variability in interpretation of myocardial ischemia on cardiac stress tests between enrollment sites and core laboratories in the global ISCHEMIA trial population with chronic coronary disease and moderate-to-severe ischemia. The key finding was that interpretation consistency can vary across sites and core labs, highlighting potential differences in how ischemia is classified in a large multicenter trial. This is clinically significant because it underscores the need for harmonized stress-test reading processes to ensure reliable risk stratification and comparability of trial results.

O’Keefe E, Sperry BW, Jones PG et al. · Circulation. Population health and outcomes · (2026) · View on PubMed ↗

Use of advanced cardiovascular imaging in rheumatic immune-mediated inflammatory diseases.

This retrospective multi-centre quality improvement study evaluated real-world use of advanced cardiovascular imaging—cardiac magnetic resonance (CMR), CT coronary angiography (CTCA), and positron emission tomography (PET)—in adults with less common/rare rheumatic immune-mediated inflammatory diseases (systemic lupus erythematosus, systemic sclerosis, inflammatory myopathy, vasculitis, or primary Sjögren’s disease) undergoing imaging between 2023 and 2024. The key finding was substantial variation in imaging practice across hospitals and disease categories, highlighting inconsistent adoption patterns for CMR/CTCA/PET in these rare IMIDs. The results are significant because they identify where future studies and guideline development are needed to standardize cardiovascular imaging strategies in these populations.

Gumber L, Meghji MA, Kakkar V et al. · Rheumatology (Oxford, England) · (2026) · View on PubMed ↗ · Free PDF ↗

Comparison of Cardiac MR with PET CT in Evaluation of Myocardial Viability: Single-Center Experience.

This prospective single-center study compared cardiac MRI (including end-diastolic wall thickness [EDWT] measured manually and with semiautomatic software, regional wall motion abnormalities, and late gadolinium enhancement [LGE]) against PET-CT as the gold standard for myocardial viability in 28 adults with PET-CT perfusion/metabolism matched or mismatched defects. The key finding was the relative performance of specific CMR parameters (EDWT, wall motion, and LGE) in identifying infarcted/viable tissue compared with PET-CT. This is significant because it informs which CMR metrics may best substitute for or complement PET-CT when assessing myocardial viability for revascularization decisions.

Arafath MY, Debi U, Singhal M et al. · The Indian journal of radiology & imaging · (2026) · View on PubMed ↗ · Free PDF ↗

Diagnosis of cardiac pathology on acute electrocardiographic-gated thoracic computed tomography: guidance for the general radiologist.

This guidance-focused study/article addressed how to diagnose cardiac pathology on acute electrocardiographic-gated thoracic computed tomography (CT) performed for acute aortic syndrome evaluation, targeting general radiologists who interpret these datasets. The key finding was that the same gated CT datasets can reveal potentially life-threatening cardiac causes of acute presentation (including coronary atheromatous disease and related complications) but are often overlooked or misinterpreted. Scientifically and clinically, it emphasizes systematic review strategies to reduce diagnostic error and improve detection of cardiac pathology beyond the primary aortic indication.

Manghat NE, Greco F, Harries I et al. · Clinical radiology · (2026) · View on PubMed ↗

Evaluation of new vectorcardiography algorithms for identifying left ventricular hypertrophy and impaired systolic function.

This prospective diagnostic evaluation studied new vectorcardiography (VCG) algorithms for detecting left ventricular hypertrophy (LVH) and impaired systolic function, using cardiac MRI as the reference standard. It found that VCG could provide diagnostic performance for LVH and systolic impairment that may be useful for screening structural heart disease compared with routine ECG. The scientific significance is that scalable, noninvasive VCG-based algorithms could improve early detection of LVH and reduced systolic function in settings where CMR is not readily available.

Salatzki J, Schwarz AK, Wolfsteller S et al. · Journal of electrocardiology · (2026) · View on PubMed ↗ · Free PDF ↗

Impact of Microvascular Obstruction on Left Atrial and Ventricular Myocardial Deformation and In-hospital Complications in Reperfused ST-segment Elevation Myocardial Infarction Patients.

This retrospective study assessed 95 consecutive reperfused ST-segment elevation myocardial infarction (STEMI) patients who underwent cardiovascular magnetic resonance (CMR) within 7 days, comparing those with microvascular obstruction (MVO; n=30) versus without MVO. MVO presence—defined on late gadolinium enhancement (LGE) as a hypo-enhanced core surrounded by hyper-enhanced myocardium—was associated with worse left atrial and ventricular myocardial deformation metrics and higher in-hospital complication risk. These results suggest that CMR-detected MVO can serve as an early prognostic marker to stratify reperfused STEMI patients for closer monitoring and management.

Cau R, Pinna A, Bassareo PP et al. · Journal of thoracic imaging · (2026) · View on PubMed ↗

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Cardiac Amyloidosis Risk Stratification (ATTR/AL, Strain, ECV, CMR)

Enhanced risk stratification in hypertrophic cardiomyopathy through the integration of extracellular volume fraction on cardiovascular magnetic resonance.

This study evaluated whether cardiovascular magnetic resonance (CMR) extracellular volume fraction (ECV), reflecting diffuse interstitial fibrosis, adds prognostic value beyond late gadolinium enhancement (LGE) in 990 consecutive hypertrophic cardiomyopathy (HCM) patients. Over a median 3.2-year follow-up, higher ECV (quantified alongside LGE) was associated with HCM-related events (composite of sudden cardiac death events, heart failure events, and HCM-related death), improving risk stratification beyond LGE alone. Integrating ECV into CMR assessment could better identify HCM patients at higher risk for adverse outcomes.

Lee HJ, Gwak SY, Lee S et al. · European heart journal. Cardiovascular Imaging · (2026) · View on PubMed ↗

Incremental Prognostic Value of Cardiac Magnetic Resonance Beyond Biomarker Staging in Transthyretin Cardiac Amyloidosis.

This retrospective multicenter cohort study assessed whether adding cardiac magnetic resonance (CMR) parameters to National Amyloidosis Center (NAC) serum-biomarker staging improves prognosis in 266 patients with transthyretin cardiac amyloidosis (ATTR-CA). The key finding was that CMR provided incremental prognostic value beyond NAC staging for time to death, and the combined approach could better guide evaluation for advanced heart failure therapies and emerging disease-modifying treatments. Clinically, this supports using CMR alongside biomarker staging to refine risk stratification and treatment selection in ATTR-CA.

Chiou T, Minga I, Subashchandran V et al. · European heart journal. Cardiovascular Imaging · (2026) · View on PubMed ↗

Extracellular Volume Mapping by Cardiac MRI Predicts Sudden Cardiac Death in AL Amyloidosis: A South Asian Cohort Study.

This ambispective South Asian cohort study evaluated whether cardiac MRI extracellular volume (ECV) mapping at diagnosis predicts sudden cardiac death in 188 patients with AL amyloidosis, using serum free light chain restriction and biopsy-proven amyloidosis/cardiac phenotype. The key finding was that abnormal ECV (≥25%, derived from T1 mapping) was associated with subsequent sudden cardiac death risk compared with normal ECV (<25%). Clinically, ECV provides a noninvasive cardiac biomarker to identify AL amyloidosis patients at higher risk for sudden death and may support earlier intervention.

Pattnaik SA, Ahamed H, Gutjahr G et al. · Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion · (2026) · View on PubMed ↗ · Free PDF ↗

The Diagnostic and Prognostic Value of Multi-Chamber Strain Analysis by Cardiac MRI in Amyloidosis.

This retrospective CMR study evaluated diagnostic and prognostic value of multi-chamber myocardial strain in 47 patients with cardiac amyloidosis, correlating strain with native T1 mapping and late gadolinium enhancement (LGE) using Query Amyloid Late Enhancement (QALE) metrics. The key finding was that strain parameters across ventricles and atria correlated with amyloid imaging biomarkers (native T1/QALE and LGE) and provided prognostic information for major adverse cardiovascular events (MACE). This is significant because multi-chamber strain may improve risk stratification and diagnostic characterization of amyloidosis beyond conventional single-chamber measures.

Chilkuri SK, Dsouza R, Houbois C et al. · Journal of thoracic imaging · (2026) · View on PubMed ↗

Apical Hypertrophic Cardiomyopathy in ATTR Val142Ile Carrier: When Genes and Phenotype Diverge.

This case report described a 61-year-old African-American man with apical hypertrophic cardiomyopathy (ApHCM) who carried the pathogenic transthyretin (TTR) variant V142I, illustrating divergence between genotype and phenotype. The key finding was that technetium-99m pyrophosphate scintigraphy (H/CL 1.01, visual grade 0) and cardiac MRI confirmed apical-predominant hypertrophy with patchy late gadolinium enhancement, excluding transthyretin cardiac amyloidosis cardiomyopathy (ATTR-CM) despite genotype positivity. This is significant because it informs management by showing that TTR V142I carriers may require imaging confirmation to distinguish true ATTR-CM from phenocopies like ApHCM.

Khayat O, Moumneh MB, Salman O et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗

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Cardiac Arrhythmias & Sudden Death Risk (including MVP, Brugada, PVCs)

Improving arrhythmic risk prediction using cardiac magnetic resonance within deep learning in ischemic heart disease.

The study assessed whether deep learning applied to cardiac magnetic resonance (CMR), specifically late gadolinium enhancement (LGE-CMR) scar metrics, improves sudden arrhythmic death risk prediction in ischemic heart disease (IHD) using two independent cohorts (including REVIVED-BCIS2-derived data). LGE-CMR–based deep learning features provided incremental prognostic value for arrhythmic risk beyond conventional clinical markers such as left ventricular ejection fraction. This supports more accurate, CMR-driven risk stratification for identifying IHD patients at higher risk of arrhythmic events.

Sen A, Jones RE, Morgan H et al. · NPJ cardiovascular health · (2026) · View on PubMed ↗ · Free PDF ↗

A hidden threat in the apical shadow: a case report regarding Loeffler endocarditis mimicking NSTEMI.

This case report described a 71-year-old man with long-standing idiopathic hyper-eosinophilia who presented with chest pain and progressive dyspnoea and was ultimately diagnosed with Loeffler endocarditis (a hyper-eosinophilic syndrome cardiac manifestation) mimicking NSTEMI using cardiac MRI. Cardiac MRI showed apical endocardial fibrosis with intracavitary thrombus, and the patient was treated successfully with corticosteroids plus vitamin K antagonist anticoagulation. The report highlights the clinical importance of considering Loeffler endocarditis in NSTEMI-like presentations in patients with hyper-eosinophilia to enable timely, targeted therapy.

Caruzzo CA, Rigamonti E, Scopigni FR et al. · European heart journal. Case reports · (2026) · View on PubMed ↗

Cardiac MRI-based strain analysis for the assessment of left atrial dysfunction in patients with atrial fibrillation.

The study used cardiac magnetic resonance feature tracking (CMR-FT) to quantify left atrial (LA) strain parameters for early detection of LA dysfunction in atrial fibrillation (AF), comparing 113 AF patients with 52 age- and sex-matched healthy controls. AF patients showed impaired LA functional strain metrics (εs, εe, εa) and were stratified into groups with abnormal versus normal LA structural/functional indices (AF1 vs AF2). This suggests CMR-FT LA strain provides sensitive, earlier markers of AF-related atrial dysfunction than conventional static measures.

Zhou H, Zhu D, Hao S et al. · The international journal of cardiovascular imaging · (2026) · View on PubMed ↗ · Free PDF ↗

Sudden Cardiac Arrest and Takotsubo-Like Cardiomyopathy as the Initial Presentation of Primary Carnitine Deficiency.

This JACC Case Reports article described an 18-year-old woman who presented with ventricular fibrillation cardiac arrest and was found on cardiac MRI to have a Takotsubo-like cardiomyopathy phenotype. Genetic testing identified a homozygous pathogenic variant in SLC22A5 (c.43G>T; p.Gly15Trp), confirming autosomal recessive primary carnitine deficiency (PCD) as the underlying cause. The case underscores that PCD can present as sudden cardiac arrest with Takotsubo-like features and that genetic diagnosis can enable timely, treatable management.

Talasani N, Przybylski R, Delaney MA et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗

Lyme Myopericarditis With Effusive-Constrictive Physiology: Serial CMR Identifies a Reversible Inflammatory Phenotype.

This JACC Case Reports report described a 45-year-old man with Lyme myopericarditis presenting with effusive-constrictive physiology and serial cardiac magnetic resonance (CMR) imaging. Serial CMR demonstrated a reversible inflammatory phenotype, distinguishing inflammatory pericardial involvement from fixed constriction and guiding management implications. The case is significant because it supports using serial CMR to differentiate reversible inflammation from irreversible constriction in Lyme-associated pericardial disease.

Alhirtani N, Bigham G, Fabrizio C et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗

Prognosis of acute myocarditis beyond hospitalization: Results of a long-term prospective study.

This prospective single-center observational study followed 158 patients (mean age 32±12 years; 12.7% female) admitted with acute myocarditis from 2007–2022 to assess long-term prognosis beyond hospitalization. Over follow-up using annual clinical evaluation plus treadmill testing, Holter monitoring, and echocardiography, the study reported low but clinically meaningful rates of severe complications (3.6%) such as cardiogenic shock or arrhythmic storm. The results are significant for counseling and risk stratification of acute myocarditis survivors, emphasizing the value of structured long-term follow-up.

de Freitas Vilela MM, Martins AM, Cazeiro D et al. · Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology · (2026) · View on PubMed ↗ · Free PDF ↗

Trileaflet mitral valve in hypertrophic obstructive cardiomyopathy: A rare anatomical variant requiring surgical intervention.

This case report described a 68-year-old woman with hypertrophic obstructive cardiomyopathy (HOCM) who had a rare trileaflet mitral valve anatomy requiring surgery. Multimodal imaging (cardiac magnetic resonance and echocardiography) showed asymmetric septal hypertrophy with left ventricular outflow tract obstruction (resting gradient up to 87 mmHg) and severe mitral regurgitation with systolic anterior motion, with an anterior leaflet restriction and a clefted posterior leaflet; symptoms persisted despite beta-blocker therapy. The clinical significance is that unusual mitral valve morphology in HOCM can drive obstruction and regurgitation and may necessitate surgical intervention when medical therapy fails.

Kumar UA, Sitaranjan DR, Taghavi FJ · Perfusion · (2026) · View on PubMed ↗

Clinical Course and Predictors of Heart Failure in Asymptomatic Obstructive Hypertrophic Cardiomyopathy.

This multicenter retrospective study analyzed 341 asymptomatic patients with obstructive hypertrophic cardiomyopathy (NYHA class I, LVEF >50%, LV outflow tract gradient ≥30 mmHg) across four centers (2003–2023) to identify predictors of progression to symptomatic heart failure. Using transthoracic echocardiography and longitudinal follow-up, it evaluated clinical and imaging factors associated with development of heart failure in patients who were initially asymptomatic. Scientifically and clinically, defining predictors of symptomatic progression can refine surveillance intensity and risk-based management in obstructive HCM.

Schulz A, Maron MS, Peng LW et al. · Journal of the American Heart Association · (2026) · View on PubMed ↗ · Free PDF ↗

Treatment of Premature Ventricular Contractions: A Review of Medical Therapy, Catheter Ablation, and Emerging Treatments.

This review studied the management of premature ventricular contractions (PVCs) in patients with and without structural heart disease, focusing on medical therapy, catheter ablation, and emerging treatments. It found that clinical impact varies with symptom burden, PVC frequency, ventricular function, and underlying myocardial disease, and that PVC-induced cardiomyopathy or malignant ventricular arrhythmias can occur in selected patients. The review is clinically significant because it synthesizes diagnostic evaluation (ECG, ambulatory monitoring, echocardiography, exercise testing, and cardiac MRI) and treatment options to guide risk-based care.

Elattar S, Hodhod A, Basha NR et al. · Cardiology in review · (2026) · View on PubMed ↗

Right ventricular thrombus following a left anterior descending infarction: a rare case report of a common culprit.

This case report studied a 39-year-old man who developed a rare right ventricular (RV) thrombus after an anterior ST-elevation myocardial infarction (STEMI) due to a thrombotic occlusion of the mid-left anterior descending (LAD) artery in a left-dominant coronary system. The key finding was that advanced cardiac imaging supported RV thrombus as an infarct-extension complication despite the typical association with inferior infarcts or pulmonary embolism. This is significant because it broadens clinicians’ diagnostic consideration of RV thrombus after anterior STEMI and highlights the value of advanced cardiac imaging for atypical thrombotic presentations.

Bigvava T, Hoechli A, Anabitarte P et al. · European heart journal. Case reports · (2026) · View on PubMed ↗

A case of cardiac lymphangioma: diagnosis suggested by cardiac CT and MRI and successful conservative management.

This case report studied a 78-year-old woman with cardiac lymphangioma, a rare benign tumor, using multimodality imaging for diagnosis and conservative management for treatment. The key finding was that cardiac computed tomography (CT) and cardiac magnetic resonance imaging (CMR) identified a characteristic multilocular cystic, non-enhancing mass along the right coronary artery (T2 hyperintensity), enabling diagnosis without invasive intervention. This is significant because it demonstrates how CCT/CMR imaging features can guide diagnosis and support non-surgical management in an otherwise poorly standardized condition.

Kurosaka E, Matsuda J, Yanagiya N et al. · Journal of cardiology cases · (2026) · View on PubMed ↗

Zanubrutinib combined with R-CHOP in previously untreated diffuse large B-cell lymphoma with specific gene alteration: a phase II study.

This phase II study evaluated zanubrutinib combined with R-CHOP in previously untreated diffuse large B-cell lymphoma (DLBCL) patients aged 18–75 years who had high-risk molecular alterations (including MYD88, CD79B, NOTCH1, TP53 mutations and/or MYC rearrangements). The key finding was the prospective testing of a BTK inhibitor–based regimen in genomically defined high-risk disease with the goal of improving outcomes compared with historical R-CHOP results in these subgroups. This is significant because it targets aberrant BCR signaling pathways in specific gene-defined DLBCL subsets and informs precision first-line therapy strategies.

Zhang Q, Jiang S, Wei R et al. · Blood cancer journal · (2026) · View on PubMed ↗ · Free PDF ↗

Myocardial Calcification as a Rare Cardiac Sequela: When Sepsis Leaves Its Mark.

This JACC Case Reports report describes a 33-year-old woman who developed severe sepsis from disseminated Streptococcus pneumoniae with septic shock and marked troponin elevation but normal coronary angiography, followed by later cardiac imaging evidence of myocardial calcification. Four weeks after the initial event, repeat chest computed tomography demonstrated new extensive left ventricular and papillary muscle calcifications, supporting sepsis-related myocardial calcification as a rare sequela. Clinically, the case emphasizes that severe sepsis can leave persistent structural cardiac injury detectable on follow-up CT even when acute coronary disease is not evident.

El-Hamad A, Sene PM, El Mehdi El Yamani M et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗

CMR Reveals the Influence of Trigger and Classification on the Myocardial Tissue Response in Takotsubo Syndrome.

This study used cardiovascular magnetic resonance (CMR) to examine how trigger factors and the InterTAK classification (including the newer primary vs secondary Takotsubo syndrome distinction) relate to myocardial tissue response in Takotsubo syndrome. The key finding was that CMR measures of left ventricular function, myocardial edema, and myocardial injury differed according to trigger/classification, indicating distinct underlying pathophysiology between primary and secondary TTS phenotypes. This is significant because CMR-based characterization could improve risk stratification and mechanistic understanding beyond trigger-based clinical labels.

Gotschy A, Cammann VL, Schweiger V et al. · Circulation. Cardiovascular imaging · (2026) · View on PubMed ↗

Atypical Case of Takayasu Aortitis Presenting as Embolic Stroke With Concomitant Massive Thoracic Artery Aneurysm.

This clinical case report describes a 44-year-old woman with Takayasu aortitis presenting with embolic stroke and concomitant massive thoracic artery aneurysm, ultimately treated with open surgical repair using a Dacron graft. The key finding was that surgical pathology showed granulomatous inflammation consistent with autoimmune or infectious etiology, aligning with the diagnosis of Takayasu aortitis as the underlying cause of embolic events. The case is significant because it highlights an atypical presentation of Takayasu aortitis where prompt recognition and surgical management may be required to prevent recurrent embolization.

Henson JC, Myers JH, Cummins M et al. · Clinical case reports · (2026) · View on PubMed ↗ · Free PDF ↗

A Case of Brugada Syndrome… or Something Else? Behind Type 1 Brugada Pattern.

This case report describes a 51-year-old man with syncope during a febrile illness who had a transient spontaneous type-1 Brugada ECG pattern, raising concern for Brugada syndrome versus alternative diagnoses. Holter monitoring revealed multifocal ventricular ectopy including non-sustained ventricular tachycardia (NSVT), and the report emphasizes that overt myocardial scar and arrhythmogenic substrate should prompt reconsideration of the diagnosis. The clinical significance is that transient Brugada-like ECG patterns during fever can mask other structural arrhythmia substrates, requiring careful rhythm monitoring and further evaluation.

Scarà A, Borrelli A, Romano S et al. · Clinical case reports · (2026) · View on PubMed ↗ · Free PDF ↗

CAR-T Cell Therapy Versus Salvage Chemotherapy in Relapsed/Refractory DLBCL: A Systematic Review and Meta-Analysis Integrating Radiologic, Laboratory, and Histopathologic Correlates.

This systematic review and meta-analysis compared chimeric antigen receptor T-cell (CAR-T) therapy versus salvage chemotherapy in adult patients with relapsed/refractory diffuse large B-cell lymphoma (R/R DLBCL), integrating radiologic, laboratory, and histopathologic correlates. The key finding was that CAR-T outcomes can be more favorable than salvage chemotherapy across included comparative studies, with effectiveness potentially influenced by high-risk molecular features and primary refractory status. Clinically, the work supports CAR-T as a preferred strategy for selected R/R DLBCL patients and highlights the value of multimodal biomarkers to refine treatment selection.

Elsayed FM, Baban J, Elkholy HY et al. · La Clinica terapeutica · (2026) · View on PubMed ↗

Autologous Stem Cell Transplantation Of HIV-Positive Plasmablastic Lymphoma - Case Series.

This case series studied autologous stem cell transplantation (ASCT) as consolidation in HIV-positive patients with plasmablastic lymphoma (PBL) achieving first complete response (CR1) under highly active antiretroviral therapy (HAART). The key finding was that ASCT was feasible and could be delivered with acceptable safety and efficacy in this previously high-risk population. Scientifically and clinically, it supports reconsidering ASCT eligibility for HIV-associated PBL in the HAART era and informs risk–benefit decisions for consolidation therapy.

Giri Raja Pandiyan VM, Perumal Kalaiyarasi J, Govindarajan DD et al. · Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion · (2026) · View on PubMed ↗

Septic cardiomyopathy: Fact or fiction?

This narrative review examined whether septic cardiomyopathy (SCM) is a distinct clinical entity (“fact or fiction”) in the setting of sepsis. The key finding was that SCM is characterized by acute, dynamic myocardial dysfunction with potential reversibility over days, but it remains poorly standardized and overlaps with other acute cardiomyopathies such as Takotsubo cardiomyopathy and myocarditis. Scientifically, the review highlights the need for standardized diagnostic criteria and improved differentiation to guide management in septic patients.

Naimi A, Rodriguez M, Qadeer YK et al. · American heart journal plus : cardiology research and practice · (2026) · View on PubMed ↗ · Free PDF ↗

CTLA4-Ig + Anti-IL-6/IL-6R Treatment Results in Long-term Allograft Survival and Function in Highly HLA-sensitized Patients.

This study evaluated long-term outcomes after kidney transplantation in highly HLA-sensitized patients using a combined immunosuppressive strategy of CTLA4-Ig (abatacept) plus anti–IL-6/IL-6 receptor therapy. The key finding was that this regimen resulted in durable allograft survival and maintained allograft function while addressing rejection risk in patients with high sensitization. Clinically, it offers a potential CNI-free conversion approach for HS transplant recipients where calcineurin inhibitor toxicity limits standard therapy.

Jordan SC, Chandran S, Ammerman N et al. · Transplantation direct · (2026) · View on PubMed ↗ · Free PDF ↗

Pathological Q Waves in a Young Patient Without Ischemic Heart Disease.

This JACC Case Reports report described an 18-year-old asymptomatic man with pathological septal Q waves on electrocardiography but no ischemic heart disease, using multimodality cardiac imaging with cardiac magnetic resonance (CMR) for tissue characterization and differential diagnosis. The key finding was that CMR’s role in atypical ECG findings is central for risk stratification and therapeutic decision-making when the ECG pattern is unexplained by ischemia. Clinically, it highlights the need to investigate nonischemic causes of pathological Q waves using advanced imaging rather than assuming coronary disease.

Figueroa-Galván FS, Alanís-Naranjo JM, González-Najera MF et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗

Assessment of left atrioventricular coupling index in hypertrophic cardiomyopathy: improving risk stratification with cardiac magnetic resonance (CMR).

This retrospective study analyzed 2,240 patients with hypertrophic cardiomyopathy (HCM) to assess whether the left atrioventricular coupling index (LACI)—defined as the ratio of left atrial end-diastolic volume to left ventricular end-diastolic volume—predicts sudden cardiac death (SCD) and adds prognostic value beyond guideline-based risk models. The key finding was that LACI derived from clinical and CMR data (along with LGE and LVEF) improved risk stratification for SCD events and provided incremental prognostic information in multivariable Cox models. Clinically, this supports incorporating LACI into CMR-based HCM risk assessment to better identify patients at higher SCD risk.

Zhang D, Qian Y, Gu Z et al. · Clinical radiology · (2026) · View on PubMed ↗

Filamin C Genetic Cardiomyopathy Presenting as Acute Myocardial Injury.

This JACC Case Reports report described a 46-year-old man with acute myocardial injury presenting with nonischemic imaging features, where cardiac magnetic resonance showed extensive ring-like subepicardial late gadolinium enhancement involving 10 left ventricular segments without myocardial edema. The key finding was that genetic testing identified a pathogenic FLNC (filamin C) variant, and follow-up imaging demonstrated persistent fibrosis with preserved ventricular function and no arrhythmias after 4 months. This is significant because it links a distinctive CMR pattern of nonischemic injury to FLNC genetic cardiomyopathy, guiding diagnosis and downstream surveillance.

Alexandrino FB, Curtis B, Nguyen C et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗

Discordant Cardiomyopathy Phenotypes in Siblings With Homozygous FKRP c.1100T>C.

This case report described two South African Afrikaner siblings with limb-girdle muscular dystrophy R9 who were both homozygous for the FKRP c.1100T>C (p.Ile367Thr) variant, but had discordant cardiac phenotypes. The brother developed progressive cardiomyopathy from reduced LVEF (41%) to dilated cardiomyopathy with extensive myocardial fibrosis on late gadolinium enhancement CMR (12–14 of 17 AHA segments) over ~7 years, despite partial reverse remodeling. The report highlights that even with the same FKRP genotype, cardiac disease severity and remodeling trajectory can vary substantially, complicating genotype-to-phenotype prediction and supporting individualized cardiac surveillance.

Mahon N, Coad S, Kiamanesh O · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗

Cardiac magnetic resonance-derived atrioventricular coupling index for predicting left ventricular reverse remodeling in dilated cardiomyopathy.

This retrospective study assessed whether a cardiac MRI-derived left atrioventricular coupling index (LACI) predicts left ventricular reverse remodeling (LVRR) in 64 hospitalized patients with dilated cardiomyopathy receiving standardized guideline-directed medical therapy. The key finding was that LACI (tested in multivariable models alongside either left atrial strain or left ventricular strain) improved prediction of LVRR over follow-up at one year. Scientifically, it suggests that MRI-based atrioventricular coupling metrics can serve as actionable imaging biomarkers to identify DCM patients likely to benefit from therapy with reverse remodeling.

Ke J, Zhang C, Wang X et al. · Clinical radiology · (2026) · View on PubMed ↗

Imaging of Myocardial Carcinoid Metastasis.

This JACC Case Reports case series studied two patients with metastatic neuroendocrine tumors (NETs) presenting with isolated myocardial carcinoid metastases. In both cases, myocardial lesions were first detected on Gallium-68 DOTATATE PET/CT and then characterized with cardiac MRI, while transthoracic echocardiography had limited sensitivity for identifying myocardial involvement. The clinical significance is that multimodality imaging—especially DOTATATE PET/CT followed by CMR—can improve detection and characterization of otherwise under-recognized cardiac metastases.

Ranganath S, Ynalvez L, Ryoo Ali HJ et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗

Unexplained Supraventricular Tachycardia and Myocardial Injury After Bitter Orange Supplement Use in a Young Woman.

This case report studied a 38-year-old woman who developed unexplained supraventricular tachycardia and myocardial injury after using a bitter orange (Citrus aurantium) weight-loss supplement containing p-synephrine. The key findings were ECG-documented supraventricular tachycardia responsive to 6 mg IV adenosine and a marked rise in high-sensitivity troponin I (from 17.9 to 1,395.7 ng/L) after supplement exposure. The significance is that sympathomimetic bitter orange/p-synephrine supplements can precipitate clinically significant arrhythmia and myocardial injury, warranting prompt recognition and avoidance.

Plaitis A, Grigoraki E, Karakosta M et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗

Malignant Mitral Valve Prolapse With Life-Threatening Ventricular Arrhythmias: A Multidisciplinary Team-Guided Stepwise Management.

This JACC Case Reports article described a 45-year-old woman with bileaflet myxomatous mitral valve prolapse and mitral annular disjunction who developed malignant ventricular arrhythmias with recurrent ventricular fibrillation and multiple ICD shocks despite medical therapy. The key clinical finding was that life-threatening arrhythmias occurred even without severe mitral regurgitation and without detectable myocardial fibrosis on cardiac MRI, prompting a stepwise multidisciplinary risk-management approach. The significance is that “malignant” arrhythmogenic MVP can be present without classic CMR fibrosis or severe MR, so combined electrical and mechanical risk markers are crucial for identifying imminent sudden cardiac death risk.

Javadi N, Jahangir A, Galazka P et al. · JACC. Case reports · (2026) · 1 citations · View on PubMed ↗ · Free PDF ↗

A case report of nonrheumatic myocarditis following group G streptococcus pharyngitis.

This case report described a 22-year-old man who developed nonrheumatic myocarditis after group G streptococcal pharyngitis. Cardiac MRI showed focal myocardial hyperintensity on T2-weighted imaging with elevated T2 values, supporting myocarditis in the post-bacterial setting. The report highlights that although post-bacterial myocarditis is rare, cardiac MRI can be pivotal for diagnosis and risk assessment after group G streptococcal infection.

Perkins SJ, Lim JGS, Gans C et al. · Radiology case reports · (2026) · View on PubMed ↗ · Free PDF ↗

A Stepwise Multimodality Imaging Approach to Out-of-Hospital Cardiac Arrest in Cystic Fibrosis.

This case report described a 25-year-old man with cystic fibrosis who presented with ventricular fibrillation during a pulmonary exacerbation complicated by hemoptysis and hypoxemia. After resuscitation, diagnostic workup using ECG, high-sensitivity troponin, and echocardiography suggested myocardial injury and regional wall motion abnormalities despite the absence of ST-segment elevation, illustrating a diagnostic challenge in young OHCA patients with low atherosclerotic pretest probability. The case supports a stepwise multimodality imaging approach to identify non-atherosclerotic cardiac causes of out-of-hospital cardiac arrest in cystic fibrosis.

Frittella S, Iuvara G, Angeli F et al. · The American journal of cardiology · (2026) · View on PubMed ↗ · Free PDF ↗

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Generated automatically on July 06, 2026. Covers PubMed articles published June 29, 2026 – July 06, 2026. Summaries are AI-generated; always consult the original publication for clinical or research decisions.