What's New in Cardiac MRI? — July 10, 2026
AI-summarised digest of 58 PubMed articles on Cardiac MRI published in the last 7 days.
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What’s New in Cardiac MRI?
July 10, 2026 · 58 articles · 15 research themes · covering July 03, 2026 – July 10, 2026
Overview
Across this week’s set of studies and reviews, a dominant theme is the expanding role of cardiac magnetic resonance (CMR) as both a diagnostic “tissue microscope” and a practical risk-stratification tool. Multiple papers focus on improving CMR workflows and quantification—such as streamlined multi-parametric tissue characterization (including free-breathing approaches), ferumoxytol-enhanced whole-heart imaging optimization, and 4D flow validation platforms—while others show how CMR-derived metrics (e.g., ECV for diffuse fibrosis, LGE for scar, mapping parameters, and perfusion measures) can refine prognosis in hypertrophic cardiomyopathy, atrial fibrillation, transplant rejection surveillance, and ischemic injury.
A second major thread is mechanism-informed management of cardiomyopathies and inflammatory cardiac syndromes. Long-term myocarditis outcomes, arrhythmic myocarditis risk reviews, and myocarditis-like presentations tied to genetic or metabolic causes (e.g., desmosomal cardiomyopathy concepts, primary carnitine deficiency, and stress/Takotsubo phenotypes) emphasize that “inflammation” is often a gateway to underlying biology. In parallel, hypereosinophilic syndromes (Loeffler/endomyocarditis) and paraneoplastic eosinophilic myocarditis are highlighted as conditions where multimodal imaging plus targeted therapy (anti-inflammatory and/or myeloma-directed treatment) can be life-saving and potentially reversible.
Finally, several studies underscore the move toward earlier detection and better patient selection—whether for heart failure prevention (Stage B/HFpEF-spectrum risk scores), silent ischemia in obesity, or atrial remodeling and ablation planning using CMR scar surrogates and electrogram-based machine learning. Complementing these clinical advances, reviews and case reports address cardiotoxicity (notably fluoropyrimidines), endothelial activation biomarkers in Fabry disease, and the broader public-health and systems context (e.g., asbestos-related cancer burden, OSA’s cerebrovascular mortality link, and infection-prevention evidence gaps).
Cardiac MRI & Tissue Characterization Methods (CMR workflows, mapping, fibrosis quantification)
Multimodality imaging of extensive caseous-calcific myocardial involvement mimicking a cardiac mass.
This case report used multimodality imaging to evaluate a 73-year-old asymptomatic woman with a presumed cardiac mass on echocardiography. Cardiac MRI characterized extensive caseous-calcific myocardial involvement with septal and posterior mitral annular lesions showing markedly reduced native T1/T2 values, hypoperfusion on first-pass perfusion, and peripheral late gadolinium enhancement around a non-enhancing calcified core. The clinical significance is improved noninvasive differentiation of calcific/infiltrative mimics of cardiac tumors, reducing unnecessary interventions.
Frittella S, Lo Monaco M, Mollace R et al. · The international journal of cardiovascular imaging · (2026) · View on PubMed ↗
[Cardiovascular magnetic resonance imaging: routine use in cardiology and unique strengths].
This narrative review discussed the routine use and unique strengths of cardiovascular magnetic resonance (CMR) in cardiology, focusing on its combined functional assessment and noninvasive tissue characterization. It highlighted key applications including stress perfusion CMR for coronary artery disease and Lake Louise–based CMR for inflammatory myocardial diseases, enabling differentiation between acute and other inflammatory patterns. The scientific significance is consolidating evidence-based CMR roles to support more accurate diagnosis across ischemic and inflammatory cardiac conditions.
Schulz A, Reiter T · Innere Medizin (Heidelberg, Germany) · (2026) · View on PubMed ↗
Clinical Feasibility of Free-Breathing Volumetric Comprehensive Tissue Characterization via the Multi-parametric SAVA Technique.
This work evaluated the clinical feasibility of a free-breathing, volumetric, comprehensive tissue characterization approach using the multi-parametric SAVA technique (3D mSAVA) in patients, including pre-/post-contrast T1, T2, extracellular volume (ECV), and synthesized bright-blood/dark-blood LGE. The authors reported that 3D free-breathing mSAVA produced usable tissue maps and LGE outputs and demonstrated performance/measurement agreement with conventional reference techniques such as standard T1 mapping, T2 mapping, and phase-sensitive inversion recovery (PSIR). This is significant because it supports a more streamlined, clinically adoptable “one-stop” CMR workflow for myocardial tissue characterization.
Jiang Y, Si D, Cai Q et al. · Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · (2026) · View on PubMed ↗ · Free PDF ↗
Ferumoxytol dose optimization for three-dimensional whole-heart magnetic resonance imaging in patients with congenital heart disease.
This prospective study optimized ferumoxytol dosing for 3D whole-heart (WH) CMR at 1.5 T in 45 pediatric and young patients with congenital heart disease using sequential dose escalation regimens (1 mg/kg→2 mg/kg or 2 mg/kg→3 mg/kg). The key finding was that increasing ferumoxytol dose improved physiologic blood-pool nulling behavior, reflected by changes in blood-pool nulling inversion time (TI), and enhanced 3D WH image quality. This is clinically significant because it provides dosing guidance to improve image quality and reliability of ferumoxytol-enhanced CMR in children and young patients.
Erdem S, Hussain T, El Jerbi A et al. · Pediatric radiology · (2026) · View on PubMed ↗ · Free PDF ↗
A Physiologic Left Ventricle Flow Phantom for 4D Flow MRI Applications and CFD Verification.
This engineering study developed a physiologic left ventricle (LV) flow phantom for 4D flow MRI applications and computational fluid dynamics (CFD) verification, designed to reproduce cardiac motion in a closed-loop circulation system. The phantom used a PVA-based hydrogel to provide MRI-compatible contrast and mechanical stability, enabling repeatable end-diastolic and end-systolic geometries for robust model validation. Its significance is providing a controllable, MRI-compatible ground truth platform to reduce in vivo limitations like scan time and motion artifacts when validating 4D flow MRI and CFD pipelines.
Wiegand M, Obermeier L, Dillinger H et al. · Annals of biomedical engineering · (2026) · View on PubMed ↗ · Free PDF ↗
Learning curves in Versius-assisted colorectal surgery: a risk-adjusted CUSUM analysis from a single center.
This retrospective single-center study used risk-adjusted CUSUM (RA-CUSUM) learning-curve modeling to evaluate procedure- and operator-specific performance in Versius-assisted robotic colorectal cancer surgery. Across adult patients undergoing right hemicolectomy, sigmoid resection, and anterior rectal resection, learning curves were assessed using skin-to-skin operative time adjusted for patient- and procedure-specific variables. The findings provide a quantitative framework for credentialing and optimizing adoption of the Versius system in colorectal surgery.
Sachańbiński T, Miodoński M, Kropieniewicz J · International journal of colorectal disease · (2026) · View on PubMed ↗ · Free PDF ↗
Cardiac MRI for Ischemia, Microvascular Dysfunction, and Silent Infarction
Unmasking Coronary Microvascular Dysfunction in Hypertrophic Cardiomyopathy: Multimodality Imaging With Stress Cardiac MRI and Coronary CT Angiography.
This case report used multimodality imaging—stress cardiac MRI and coronary CT angiography—to unmask coronary microvascular dysfunction (CMD) in a 21-year-old woman with hypertrophic cardiomyopathy (HCM). Imaging demonstrated CMD consistent with HCM-related microvascular ischemia, integrating functional and anatomic assessment to confirm the diagnosis. The significance is that stress CMR plus coronary CT angiography can clarify CMD mechanisms in HCM when symptoms and standard testing are insufficient.
Ufuk F · Case reports in radiology · (2026) · View on PubMed ↗ · Free PDF ↗
Cardiac myosin-binding protein C in ST-elevation myocardial infarction.
This study assessed cardiac myosin-binding protein C (cMyC) as a biomarker of myocardial injury in reperfused acute ST-segment elevation myocardial infarction (STEMI), comparing its relationship to final infarct size and microvascular obstruction (MVO) measured by late gadolinium enhancement (LGE) CMR and to hs-cTnI. The key finding was that cMyC correlated with acute and final MI size on LGE CMR and was associated with the presence of acute MVO on CMR. This supports cMyC as a potentially earlier and more informative biomarker of infarct severity and microvascular damage than troponins in reperfused STEMI.
Rajakulasingam R, Alaour B, McGrath S et al. · European heart journal. Acute cardiovascular care · (2026) · 1 citations · View on PubMed ↗ · Free PDF ↗
Viability testing for guiding revascularization in ischemic cardiomyopathy.
This review studied the clinical role of myocardial viability testing for guiding revascularization decisions in patients with ischemic cardiomyopathy, focusing on evidence from contemporary revascularization strategies and guideline-directed medical therapy. It reports that major trials such as STICH and follow-up show coronary artery bypass grafting (CABG) improves long-term survival largely independent of myocardial viability status. The finding challenges the traditional assumption that identifying dysfunctional but viable myocardium reliably predicts functional recovery and supports reappraisal of when viability testing should be used in modern practice.
Li KY, Dhingra NK, Patel R et al. · Current opinion in cardiology · (2026) · View on PubMed ↗
Left Ventricular Unloading in Anterior ST-Segment Elevation Myocardial Infarction Without Shock: The ST-Segment Elevation Myocardial Infarction Door to Unload Randomized Controlled Trial.
This randomized controlled trial tested whether mechanical left ventricular (LV) unloading using a transvalvular microaxial flow pump (TV-mAFP) combined with delayed reperfusion reduces infarct size versus reperfusion alone in patients with anterior ST-segment elevation myocardial infarction (STEMI) without cardiogenic shock. The key finding was that the LV unloading strategy aimed to reduce infarct size by lowering LV wall tension/load during the ischemia-reperfusion transition. If confirmed by the trial results, this would support a new adjunctive mechanical approach to PCI in anterior STEMI patients to mitigate progression to heart failure.
Kapur NK, Mangner N, Aghili N et al. · Journal of the American College of Cardiology · (2026) · 5 citations · View on PubMed ↗
Prevalence and prognostic impact of unrecognized myocardial infarction detected by cardiac magnetic resonance in Thai patients with obesity.
This cohort study evaluated Thai patients with obesity (BMI ≥25 kg/m2; n=1,053) without prior myocardial infarction (MI) or coronary revascularization to determine the prevalence and prognostic impact of unrecognized MI (UMI) detected by cardiac magnetic resonance (CMR). CMR-detected UMI was common in this obesity population and was associated with worse subsequent outcomes during follow-up. The findings support CMR as a tool to uncover silent ischemic injury in Asian patients with obesity and to refine cardiovascular risk prediction.
Chayanopparat P, Siriphiphatcharoen P, Laohabut I et al. · PloS one · (2026) · View on PubMed ↗ · Free PDF ↗
Molecular mechanisms of coronary microembolization-induced MINOCA.
This mechanistic review investigated the molecular pathways by which coronary microembolization (CME) can cause myocardial infarction with non-obstructive coronary arteries (MINOCA), emphasizing that diagnosis is often delayed because cardiac MRI is typically performed days after the index event. The authors conclude that CME is a major underlying pathology in MINOCA but that its molecular mechanisms remain insufficiently defined, limiting rapid diagnostic tools and targeted therapies. Scientifically, clarifying CME’s molecular drivers could enable earlier MINOCA diagnosis and development of mechanism-based treatments.
Iske J, Thau H, Mesfin JM et al. · Basic research in cardiology · (2026) · View on PubMed ↗ · Free PDF ↗
Fully quantitative CMR rest perfusion reveals myocardial perfusion abnormality in Kawasaki disease: Association with left ventricular Remodeling.
This prospective single-center study assessed myocardial perfusion abnormality in 87 children with Kawasaki disease using fully quantitative cardiac MRI (rest perfusion) with myocardial blood flow (MBF) corrected for heart rate–blood pressure product (MBFcor), and related perfusion findings to left ventricular remodeling. The study found that perfusion abnormalities were present in Kawasaki disease and were associated with subsequent LV remodeling measures. These results support quantitative CMR rest perfusion as a noninvasive way to characterize myocardial injury distribution and risk of structural remodeling in pediatric Kawasaki disease.
Zhou Z, Ye P, Wang C et al. · International journal of cardiology · (2026) · View on PubMed ↗
Characteristics and outcomes of patients undergoing coronary computed tomography angiography for suspected acute coronary syndrome in the emergency department.
This retrospective emergency-department cohort study characterized outcomes of 198 consecutive patients with suspected acute coronary syndrome (ACS) who underwent coronary computed tomography angiography (CCTA) after cardiology assessment. The primary endpoint was a composite of major adverse cardiovascular events (MACE: all-cause death, acute myocardial infarction, or myocardial revascularization), and the study reported event rates and clinical characteristics in this CCTA-referral population. The results inform how CCTA-based evaluation performs in real-world ED suspected-ACS pathways and may guide triage and downstream management decisions.
Ciliberti G, Compagnucci P, Finori L et al. · The international journal of cardiovascular imaging · (2026) · View on PubMed ↗
Myocarditis, Inflammatory Cardiomyopathies, and Arrhythmic Risk
An unexpected sequel to happiness: happy heart syndrome.
This Oxford Medical Case Reports article described a 65-year-old woman who developed Takotsubo cardiomyopathy triggered by a positive emotional event (happy heart syndrome) after attending a wedding. She presented with anginal chest pain and ECG ST-segment elevation that normalized on repeat ECG with QT prolongation and T-wave inversion, alongside elevated troponin. The report is clinically significant because it reinforces that emotional triggers can precipitate transient cardiomyopathy and that serial ECG and biomarker assessment are important for diagnosis and monitoring.
Rhabneh L, Wafi J, Ababneh R et al. · Oxford medical case reports · (2026) · View on PubMed ↗ · Free PDF ↗
Arrhythmic Myocarditis and Prevention of Sudden Cardiac Death: Current Evidence, Risk Stratification, and Management.
This review synthesized current evidence on arrhythmic myocarditis, focusing on sudden cardiac death (SCD) prevention, including risk stratification and management strategies. It emphasized that ventricular arrhythmias occur in a substantial minority of hospitalized acute myocarditis patients (often early in the inflammatory phase) and that cardiac magnetic resonance findings such as late gadolinium enhancement (LGE) integrate with clinical presentation, ventricular function, arrhythmic burden, and genetic variants for risk assessment. The clinical significance is improved identification of high-risk patients who may require intensified monitoring and targeted therapies to prevent SCD.
Imazio M, Collini V, Tomat M et al. · Hellenic journal of cardiology : HJC = Hellenike kardiologike epitheorese · (2026) · View on PubMed ↗ · Free PDF ↗
From inflammation to inheritance: rethinking myocarditis as the first signal of desmosomal cardiomyopathy.
This narrative review argued that myocarditis may be the first clinical signal of an underlying genetic desmosomal cardiomyopathy rather than purely an acquired inflammatory disorder. It synthesizes evidence linking desmosomal dysfunction (via genetic variants in desmosomal genes) with myocarditis-like presentations and highlights the role of molecular genetics, cardiac magnetic resonance (CMR), and translational pathology in distinguishing these entities. The scientific significance is a shift toward earlier genetic evaluation in selected myocarditis cases to enable diagnosis and management of inherited cardiomyopathies.
AbdelMassih AF, Sankari AC, Mallouka G et al. · The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology · (2026) · View on PubMed ↗ · Free PDF ↗
Improving arrhythmic risk prediction using cardiac magnetic resonance within deep learning in ischemic heart disease.
This study aimed to improve arrhythmic risk prediction in ischemic heart disease (IHD) by integrating late gadolinium enhancement cardiac magnetic resonance (LGE-CMR) scar metrics with deep learning models. Using two independent IHD cohorts (including REVIVED-BCIS2-derived Dataset 2 with n=424 and 50 events, and Dataset 1 with n=399 and 54 events), the authors assessed whether LGE-CMR features add prognostic value beyond conventional markers such as left ventricular ejection fraction. The clinical significance is that deep learning leveraging LGE-CMR may better stratify patients at risk of sudden arrhythmic death, potentially improving selection for preventive therapies.
Sen A, Jones RE, Morgan H et al. · NPJ cardiovascular health · (2026) · View on PubMed ↗ · Free PDF ↗
Sudden Cardiac Arrest and Takotsubo-Like Cardiomyopathy as the Initial Presentation of Primary Carnitine Deficiency.
This JACC Case Reports article described an 18-year-old woman who presented with ventricular fibrillation cardiac arrest and was found to have a Takotsubo-like cardiomyopathy phenotype on cardiac MRI. Genetic testing identified a homozygous pathogenic variant in SLC22A5 (c.43G>T; p.Gly15Trp), confirming autosomal recessive primary carnitine deficiency (PCD). The case underscores that PCD can present as sudden cardiac arrest with stress cardiomyopathy-like imaging, supporting early genetic and metabolic evaluation in unexplained VF/cardiomyopathy.
Talasani N, Przybylski R, Delaney MA et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗
Prognosis of acute myocarditis beyond hospitalization: Results of a long-term prospective study.
This prospective single-center cohort followed 158 patients admitted with acute myocarditis between 2007 and 2022, assessing long-term prognosis using annual clinical evaluation plus treadmill testing, Holter monitoring, and echocardiography. Over follow-up, the study reported the frequency of severe complications (including cardiogenic shock or arrhythmic storm at 3.6%) and evaluated outcomes with Cox regression. These long-term data improve risk stratification beyond hospitalization for acute myocarditis patients using practical follow-up testing.
de Freitas Vilela MM, Martins AM, Cazeiro D et al. · Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology · (2026) · View on PubMed ↗ · Free PDF ↗
Hypereosinophilic Syndromes, Loeffler/Endomyocarditis, and Paraneoplastic Cardiac Disease
Severe hypereosinophilia and eosinophilic myocarditis during secondary plasma cell leukemia: evidence of a paraneoplastic manifestation of aggressive myeloma evolution.
This case report described a 40-year-old woman with IgG lambda multiple myeloma who developed severe hypereosinophilia and eosinophilic myocarditis during progression to secondary plasma cell leukemia. The patient achieved complete remission after daratumumab-based induction therapy and autologous stem cell transplant, supporting eosinophilic myocarditis as a paraneoplastic manifestation of aggressive myeloma evolution. Scientifically and clinically, it highlights a rare but life-threatening cardiovascular complication to consider during advanced plasma cell neoplasms and suggests that controlling the underlying myeloma can reverse the eosinophilic process.
Catini ME, Garibotto M, Morelli MC et al. · Annals of hematology · (2026) · View on PubMed ↗
Loeffler’s Endomyocarditis: Clinical characteristics and outcomes from a tertiary care centre registry.
This retrospective single-center registry study analyzed 18 patients with Loeffler’s endomyocarditis (hypereosinophilic syndrome cardiac involvement) diagnosed between 2017 and 2025 using clinical data, biomarkers, echocardiography, cardiac magnetic resonance (CMR), and endomyocardial biopsy (n=8). Unsupervised hierarchical clustering identified two clinical patterns: an acute inflammatory form with elevated troponin T, C-reactive protein, fever, and subepicardial late gadolinium enhancement, and a more chronic restrictive pattern (as suggested by the reported clustering). The findings are significant because they help stratify disease phenotype using multimodal imaging and biomarkers, which may inform prognosis and management strategies.
Buske P, Krieghoff C, Lücke C et al. · International journal of cardiology · (2026) · View on PubMed ↗
A hidden threat in the apical shadow: a case report regarding Loeffler endocarditis mimicking NSTEMI.
This case report described a 71-year-old man with long-standing idiopathic hyper-eosinophilia who presented with chest pain and dyspnoea and was ultimately diagnosed with Loeffler endocarditis mimicking NSTEMI. Cardiac MRI demonstrated apical endocardial fibrosis with intracavitary thrombus, and the patient was treated with corticosteroids plus vitamin K antagonist anticoagulation. The report highlights the need to consider hyper-eosinophilic syndrome–related Loeffler endocarditis in NSTEMI-like presentations to avoid misdiagnosis and to initiate appropriate anti-inflammatory and anticoagulant therapy.
Caruzzo CA, Rigamonti E, Scopigni FR et al. · European heart journal. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗
Fabry Disease: Diagnosis, Biomarkers, and Cardiac Monitoring
Cardiological aspects of Fabry disease: from diagnosis to therapeutic efficacy assessment.
This review article summarizes how Fabry disease, caused by deficient α-galactosidase A activity leading to lysosomal dysfunction and globotriaosylceramide accumulation, is diagnosed and monitored for cardiac involvement using ECG, echocardiography, cardiac magnetic resonance (CMR), and cardiac biomarkers such as troponin and NT-proBNP. It emphasizes that Fabry cardiomyopathy is the leading cause of morbidity and mortality and frames imaging/biomarker assessment as key for therapeutic efficacy evaluation. The clinical significance is improved recognition and longitudinal monitoring of cardiac disease in Fabry patients to better guide treatment decisions.
Graziani F, Biagini E, Argirò A et al. · Orphanet journal of rare diseases · (2026) · View on PubMed ↗
Multimodality imaging of myocardial injury and coronary microvascular dysfunction in congenital thrombotic thrombocytopenic purpura.
This case report described subclinical cardiac involvement in a patient with congenital thrombotic thrombocytopenic purpura due to ADAMTS13 deficiency who temporarily discontinued enzyme replacement therapy. The patient demonstrated myocardial fibrosis/scarring and impaired myocardial flow reserve, assessed using cardiac magnetic resonance and PET myocardial perfusion imaging. The report highlights that multimodality imaging can detect early cardiac injury in ADAMTS13-related disease even when clinical symptoms are absent.
Kumar A, Khokhlov L, O’Donnell R · The international journal of cardiovascular imaging · (2026) · View on PubMed ↗
VCAM-1 as a biomarker of early cardiac phenotypic changes in Fabry disease.
This exploratory single-center cross-sectional study assessed whether vascular cell adhesion molecule-1 (VCAM-1) is associated with early cardiac phenotypic changes in 14 genetically confirmed Fabry disease (FD) adults from one family carrying the GLA p.Arg363His variant, compared with 30 age- and kidney-function-matched healthy controls. VCAM-1 was linked to early cardiac phenotypic alterations in FD, supporting endothelial activation as an early biomarker signal in this specific GLA variant population. These findings suggest VCAM-1 could help identify early cardiac involvement in FD before overt clinical progression, enabling earlier risk stratification and monitoring.
Lino DODC, Meneses GC, de Almeida IM et al. · BMC cardiovascular disorders · (2026) · View on PubMed ↗ · Free PDF ↗
Hypertrophic Cardiomyopathy (HCM): Prognosis, Imaging Biomarkers, and Phenotyping
Sex-disaggregated data in hypertrophic cardiomyopathy: a targeted literature review, meta-analysis and primary cohort study.
This study combined a targeted literature review, meta-analysis, and a primary cohort analysis to evaluate sex-disaggregated clinical and imaging measures in hypertrophic cardiomyopathy (HCM), including echocardiographic and cardiac MRI parameters and NT-proBNP. The key finding was that sex differences exist in presentation and biomarker/imaging metrics in HCM, supporting that outcomes and disease characteristics are not identical between men and women. Clinically, these results argue for sex-aware interpretation of HCM risk markers and may guide more tailored management and trial stratification.
Lim VG, Kokara M, Jarrett A et al. · Open heart · (2026) · View on PubMed ↗ · Free PDF ↗
Natural History of Asymptomatic Phenotypically Mild HCM: Insights From the SHaRe Registry.
This registry analysis from the Sarcomeric Human Cardiomyopathy Registry (SHaRe) studied the natural history and predictors of major adverse cardiovascular events (MACE) in phenotypically mild hypertrophic cardiomyopathy (HCM) defined by shorter disease duration (<10 years since diagnosis or age ≤30 years), NYHA class I, and no prior MACE. The study identified clinical and disease characteristics associated with incident MACE and characterized progression over follow-up in this early/milder phenotype. These data are clinically significant because they help refine risk stratification and identify which phenotypically mild HCM patients might benefit from disease-modifying strategies.
Topriceanu CC, Balakrishnan ID, Vissing CR et al. · Journal of the American College of Cardiology · (2026) · 1 citations · View on PubMed ↗
Clinical Course and Predictors of Heart Failure in Asymptomatic Obstructive Hypertrophic Cardiomyopathy.
This retrospective multicenter study evaluated predictors of progression to symptomatic heart failure in 341 asymptomatic adults with obstructive hypertrophic cardiomyopathy (NYHA class I, LVEF >50%, LV outflow tract gradient ≥30 mm Hg) using transthoracic echocardiography and clinical follow-up. The key finding was identification of clinical and echocardiographic factors associated with later development of symptomatic heart failure among patients who were initially asymptomatic. Clinically, the results help refine risk stratification and monitoring intensity for asymptomatic obstructive HCM patients to prevent or delay symptomatic deterioration.
Schulz A, Maron MS, Peng LW et al. · Journal of the American Heart Association · (2026) · View on PubMed ↗ · Free PDF ↗
Enhanced risk stratification in hypertrophic cardiomyopathy through the integration of extracellular volume fraction on cardiovascular magnetic resonance.
This European Heart Journal—Cardiovascular Imaging study tested whether cardiovascular magnetic resonance–derived extracellular volume fraction (ECV), a marker of diffuse interstitial fibrosis, adds prognostic value beyond late gadolinium enhancement (LGE) in 990 hypertrophic cardiomyopathy (HCM) patients. Over a median 3.2-year follow-up, ECV and LGE were associated with HCM-related events (including sudden cardiac death, heart failure events, and HCM-related death), and integrating ECV improved risk stratification. Clinically, adding global ECV to standard CMR fibrosis assessment could better identify HCM patients at higher risk for adverse outcomes.
Lee HJ, Gwak SY, Lee S et al. · European heart journal. Cardiovascular Imaging · (2026) · View on PubMed ↗
Atrial Fibrillation & Atrial Remodeling (imaging, genetics, ablation substrate)
Atrial Fibrosis Imaging: Correlation of Late Gadolinium Enhancement Magnetic Resonance Imaging With High-Definition Voltage Electroanatomical Mapping Across Different Thresholds.
This study evaluated whether late gadolinium enhancement (LGE) cardiac magnetic resonance imaging (CMR) atrial fibrosis quantification correlates with high-definition voltage electroanatomical mapping across different thresholds in 60 ablation-naïve atrial fibrillation (AF) patients undergoing first-time catheter ablation. The authors found that LGE-derived fibrosis measures showed meaningful agreement with electroanatomical voltage mapping, with the strength of correlation depending on the voltage threshold used. These findings support using CMR LGE as a noninvasive surrogate for atrial scar characterization to better guide AF substrate assessment and potentially improve ablation planning.
Efremidis T, Nyktari E, Kariki O et al. · Journal of cardiovascular electrophysiology · (2026) · View on PubMed ↗
Identifying the Presence and Characteristics of Mid-Myocardial and Epicardial Fibrosis From Intracardiac Electrograms in Patients Undergoing Ventricular Arrhythmia Ablation Using a Transformer-Based Self-Supervised Classifier.
This study developed and tested a transformer-based self-supervised machine learning classifier to infer mid-myocardial and epicardial fibrosis characteristics from intracardiac electrograms in patients undergoing ventricular arrhythmia ablation. The key finding was that electrogram-derived features could be used to identify scar beyond the endocardial surface, addressing limitations of relying on delayed enhancement CMR alone during procedures. This is significant because it could enable real-time, device-compatible substrate mapping to improve procedural targeting and outcomes in ventricular arrhythmia ablation.
Liu X, Qayyum A, Bandyopadhyay S et al. · Circulation. Arrhythmia and electrophysiology · (2026) · View on PubMed ↗
Multiomics Insights Into the Role of Spondin-1 in the Pathogenesis and Prognosis of Atrial Fibrillation.
This multiomics study investigated molecular drivers of atrial fibrillation (AF) by integrating Mendelian randomization and colocalization using plasma protein quantitative trait loci (pQTL) and atrial expression quantitative trait loci (eQTL) with AF genome-wide association studies. It prioritized SPON1 (spondin-1) and supported its relevance using single-nucleus RNA sequencing, spatial transcriptomics, and experimental validation. The work identifies SPON1 as a candidate protein target and helps connect genetic regulation to AF structural remodeling and prognosis.
Long X, Zhang Y, Gao X et al. · Journal of the American Heart Association · (2026) · View on PubMed ↗ · Free PDF ↗
Cardiac MRI-based strain analysis for the assessment of left atrial dysfunction in patients with atrial fibrillation.
This retrospective study evaluated whether left atrial (LA) dysfunction in atrial fibrillation (AF) can be detected earlier using cardiac magnetic resonance feature tracking (CMR-FT) LA strain parameters in 113 AF patients versus 52 matched healthy controls. AF patients showed impaired LA functional strain metrics (εs, εe, εa) and were stratified into AF1 (abnormal LAVI/LAEF) and AF2 (normal LAVI/LAEF), indicating that CMR-FT strain can capture early dysfunction beyond conventional static LA measures. The findings suggest CMR-FT LA strain could improve early identification of AF-related atrial impairment and refine risk assessment.
Zhou H, Zhu D, Hao S et al. · The international journal of cardiovascular imaging · (2026) · View on PubMed ↗ · Free PDF ↗
Heart Failure Prevention & Early Disease (Stage B/HFpEF spectrum)
Integrative Observational and Genetic Evidence From the UK Biobank Supports Carotid Intima-Media Thickness as a Window Into Cardiac Remodeling.
This UK Biobank integrative observational and genetic analysis studied associations between carotid intima-media thickness (cIMT) and cardiac remodeling/aortic traits, and tested shared genetic architecture with cardiovascular disease in 46,102 participants with carotid ultrasound and cardiac magnetic resonance imaging. The key finding was that cIMT shows phenotypic and genetic links to cardiac remodeling traits, supporting cIMT as a window into early cardiac structural changes. This provides a mechanistic bridge between subclinical atherosclerosis and cardiac remodeling, potentially improving early risk detection for future cardiovascular disease.
Chong SH, Saccoh AF, van Vugt M et al. · Journal of the American Heart Association · (2026) · View on PubMed ↗ · Free PDF ↗
The HFpEF-ABA score predicts adverse cardiac remodelling and incident heart failure: a UK biobank study.
This UK Biobank study evaluated whether the HFpEF-ABA score (age, BMI, atrial fibrillation) predicts adverse cardiac remodeling and incident heart failure in 416,374 community participants without baseline heart failure, using cardiac magnetic resonance (CMR) phenotyping for dual validation. The HFpEF-ABA score was associated with higher risk of adverse remodeling and future heart failure events. Clinically, the score could enable earlier preventive risk stratification for HFpEF-spectrum disease in unselected populations if validated as a screening tool.
Shi Q, Gao Y, Chen D et al. · ESC heart failure · (2026) · View on PubMed ↗ · Free PDF ↗
Diagnostic Tests for Stage B Heart Failure.
This narrative review summarized diagnostic approaches for Stage B heart failure (SBHF), focusing on guideline- and study-supported methods to detect subclinical myocardial remodeling and early injury before symptoms. It emphasized transthoracic echocardiography—particularly speckle tracking echocardiography—as a cornerstone, and highlighted circulating biomarkers such as natriuretic peptides and high-sensitivity cardiac troponins. The review’s significance is to consolidate practical diagnostic strategies for identifying SBHF earlier, potentially enabling earlier intervention to prevent progression to symptomatic heart failure.
Dang HNN, Luong TV, Huynh Q et al. · Current cardiology reports · (2026) · View on PubMed ↗ · Free PDF ↗
Valvular Heart Disease & Transcatheter Repair Selection (M-TEER)
Obstructive sleep apnea and rising cerebrovascular disease mortality in the United States, 1999-2020: A retrospective analysis.
This retrospective analysis examined obstructive sleep apnea (OSA) and its association with cerebrovascular disease mortality in the United States from 1999 to 2020, stratifying results by gender, race, urbanization, and geographic region. The study found that cerebrovascular disease mortality rose in parallel with OSA-related burden over time, indicating an increasing public health impact. These findings are significant for clinicians and policymakers because they support OSA as a modifiable risk factor to reduce long-term cerebrovascular mortality.
Zafar F, Jha M, Min S et al. · Sleep & breathing = Schlaf & Atmung · (2026) · View on PubMed ↗
Left ventricular excessive trabeculation: pathophysiology, diagnostic challenges, and prognostic significance.
This review article discussed left ventricular excessive trabeculation (LVET), covering its pathophysiology, diagnostic challenges, and prognostic significance, and contrasted it with the traditional concept of left ventricular non-compaction (LVNC). It concluded that LVET likely represents a heterogeneous phenotypic trait with multiple etiologies—ranging from genetic/developmental mechanisms to acquired hemodynamic adaptations—rather than a single uniform cardiomyopathy. The scientific and clinical significance is that it informs more nuanced diagnosis and risk interpretation when encountering LVET on imaging.
Beltrami M, Maestrini V, Baritussio A et al. · Heart failure reviews · (2026) · View on PubMed ↗
Diagnostic and Prognostic Utility of Mitral Annular Plane Systolic Excursion: A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis assessed the diagnostic and prognostic utility of mitral annular plane systolic excursion (MAPSE) across imaging modalities (transthoracic echocardiography, transesophageal echocardiography, and cardiovascular magnetic resonance) in human cardiovascular disease. It found that MAPSE is a fast, simple, and potentially automatable measure with evidence supporting its use for diagnosis and prognosis, despite the lack of major guideline recommendations for routine measurement. Scientifically and clinically, the synthesis supports MAPSE as a practical longitudinal function marker and motivates guideline consideration and standardization of measurement.
Falconer D, Fröjdh F, Wyeth N et al. · Journal of the American Heart Association · (2026) · View on PubMed ↗ · Free PDF ↗
Trileaflet mitral valve in hypertrophic obstructive cardiomyopathy: A rare anatomical variant requiring surgical intervention.
This case report described a 68-year-old woman with hypertrophic obstructive cardiomyopathy (HOCM) whose multimodal imaging (cardiac MRI and echocardiography) revealed a rare trileaflet mitral valve variant with anterior leaflet restriction and a clefted posterior leaflet causing severe mitral regurgitation and left ventricular outflow tract obstruction. Because symptoms persisted despite beta-blocker therapy, she underwent surgical intervention. The report highlights that unusual mitral valve anatomy can drive obstruction and regurgitation in HOCM and may necessitate surgery when medical therapy fails.
Kumar UA, Sitaranjan DR, Taghavi FJ · Perfusion · (2026) · View on PubMed ↗
An integrative approach to patient selection for mitral transcatheter edge-to-edge repair in secondary mitral regurgitation.
This review synthesized evidence and proposed a structured patient-selection framework for mitral transcatheter edge-to-edge repair (M-TEER) in secondary mitral regurgitation (SMR), integrating randomized trial data (including MITRA-FR and COAPT), proportionality concepts, and multimodality imaging. It highlighted that differing echocardiographic selection and left-ventricular remodeling likely explain divergent trial outcomes, implying SMR severity should be interpreted relative to ventricular size. The clinical significance is improving identification of SMR patients most likely to benefit from M-TEER to reduce ineffective procedures and optimize outcomes.
Brusosa M, Flores-Umanzor E, Horlick E · Current opinion in cardiology · (2026) · View on PubMed ↗
Cardiac Sarcoidosis & Endomyocardial Biopsy (EMB) Utility
Multidisciplinary approach in cardiac sarcoidosis: to biopsy or not?
This narrative review assessed the contemporary diagnostic role of endomyocardial biopsy (EMB) in cardiac sarcoidosis (CS) within a multidisciplinary framework, focusing on whether tissue diagnosis remains necessary given patchy myocardial involvement. It emphasized that EMB has historically been considered a gold standard but has limited sensitivity with false negatives and procedural risks, driving increased reliance on noninvasive imaging. The review’s significance is guiding clinicians on when EMB is most likely to add diagnostic value versus when modern imaging strategies may suffice.
Pericao A, Sharma R · Current opinion in pulmonary medicine · (2026) · View on PubMed ↗
Congenital/Structural Heart Disease & Flow Hemodynamics (4D flow, RVOT, PPVI planning)
Characteristic flow of different right ventricular outflow tract morphology in repaired tetralogy of fallot patients studied by 4D-flow cardiac magnetic resonance images.
This retrospective study used 4D-flow cardiac magnetic resonance (CMR) to characterize right ventricular outflow tract (RVOT) flow patterns in 120 patients with repaired tetralogy of Fallot (rTOF), classifying RVOT morphology as tubular or pyramidal (with other morphologies excluded due to small numbers). The key finding was that RVOT morphology type (tubular vs pyramidal) is associated with distinct flow characteristics relevant to hemodynamics and potential suitability for transcatheter pulmonic valve implantation (PPVI). This supports morphology-informed planning for PPVI by linking CMR-derived RVOT geometry to functional flow behavior.
Srivichean A, Chungsomprasong P, Sanwong Y et al. · BMC medical imaging · (2026) · View on PubMed ↗ · Free PDF ↗
Transplant Rejection Surveillance (ddcfDNA + CMR)
Abnormal Cardiac Magnetic Resonance Imaging Mapping Parameters in Pediatric Heart Transplant Patients with Elevated Donor-Derived Cell Free DNA.
This retrospective study in pediatric heart transplant patients compared multiparametric CMR trends (biventricular volumes and ejection fraction, T2 mapping, T1 mapping with extracellular volume fraction) with donor-derived cell-free DNA (ddcfDNA) measured within 30 days to distinguish patients with high versus low ddcfDNA. The key finding was that CMR mapping parameters differed in association with elevated versus low ddcfDNA, indicating that CMR tissue metrics track rejection surveillance signals. Clinically, combining ddcfDNA with multiparametric CMR could improve noninvasive detection of biopsy-proven rejection risk in pediatric transplant care.
Watanabe K, Magnetta DA, Laternser C et al. · Pediatric cardiology · (2026) · View on PubMed ↗ · Free PDF ↗
Cardiovascular Oncology & Cardiac Tumors/Sarcoma
Rare Late Cardiac Involvement Following Resected Primary Limb Dedifferentiated Liposarcoma: A Case Report.
This case report described rare late cardiac involvement after resection of primary limb dedifferentiated liposarcoma (DDLPS) in a 68-year-old woman who developed progressive dyspnea and was found to have a mediastinal mass with pericardial involvement. Cardiovascular magnetic resonance (CMR) demonstrated imaging features consistent with malignant sarcoma (e.g., heterogeneous enhancement and tissue characteristics). The report highlights the clinical significance of considering metastatic or secondary cardiac sarcoma in patients with prior DDLPS who develop new cardiopulmonary symptoms.
Alizadehasl A, Baghyari S, Salimi M · Clinical case reports · (2026) · View on PubMed ↗ · Free PDF ↗
Cardiovascular Pharmacology & Cardiotoxicity (drug-induced injury)
Long-term follow-up of a phase 1/2 trial of anti-GDF-15 antibody visugromab plus anti-PD-1 antibody nivolumab in anti-PD-1/-L1 relapsed/refractory solid tumors.
This phase 1/2a GDFATHER-01 trial evaluated the anti-GDF-15 antibody visugromab combined with the anti–PD-1 antibody nivolumab in heavily pretreated patients with anti–PD-1/PD-L1-relapsed/refractory locally advanced or metastatic non-squamous NSCLC, urothelial carcinoma, or hepatocellular carcinoma. Long-term follow-up reported durable objective responses with the V+N regimen in this anti–PD-1/PD-L1-resistant population. These findings support GDF-15 blockade as a clinically relevant strategy to overcome resistance to PD-1/PD-L1 immunotherapy and justify further development of the combination.
Melero I, de Miguel M, Cabanas EG et al. · Journal of hematology & oncology · (2026) · View on PubMed ↗
Cost-effectiveness of imaging modalities in coronary heart disease: A comprehensive review.
This comprehensive review evaluated the cost-effectiveness of coronary heart disease imaging modalities, focusing on myocardial perfusion imaging (MPI) using SPECT and PET and summarizing relevant economic evaluation studies. Across the reviewed literature, the authors emphasize that the relative value of SPECT versus PET depends on clinical selection, diagnostic performance, and healthcare cost context. The review is significant for guiding evidence-based selection of nuclear cardiology imaging strategies to improve outcomes while controlling costs.
Milan E, Giubbini R, Vitola J et al. · Seminars in nuclear medicine · (2026) · View on PubMed ↗
Fluoropyrimidine Cardiotoxicity: Role of Uridine Triacetate and Pharmacogenomic Insights from a Case of 5-FU-Induced Cardiogenic Shock.
This article reviewed fluoropyrimidine cardiotoxicity and highlighted pharmacogenomic considerations through an illustrative case of 5-fluorouracil (5-FU)-induced cardiogenic shock in a young woman without prior cardiovascular disease. It emphasizes that severe fluoropyrimidine toxicity can extend beyond coronary vasospasm to include acute heart failure, arrhythmias, and rarely fulminant cardiogenic shock, with potential roles for uridine triacetate (an antidote) and patient-specific pharmacogenomic factors in management. The clinical significance is improved recognition and treatment planning for life-threatening fluoropyrimidine cardiotoxicity, including potential use of uridine triacetate and risk-aware prescribing.
Filomia S, Del Buono MG, Saponara G et al. · Journal of cardiovascular pharmacology · (2026) · View on PubMed ↗
Targeting Arrhythmogenic Late Sodium Current by FHF1A-Derivative FixR in Heart Failure Cardiomyocytes.
This study investigated whether an engineered peptide, FixR (FHF inhibiting x region), can target the arrhythmogenic late sodium current (INa,L) pathway mediated by FHF1A in heart failure cardiomyocytes. Using reverse-transcriptase quantitative PCR to profile cardiac sodium channel and FHF splice isoforms in human HFrEF and HFpEF samples and translational animal models, the authors tested FixR’s effects and found that inhibiting the FHF1A-related modulation of INa,L can reduce proarrhythmic late sodium current activity. The work is significant because it identifies a potential mechanism- and splice-factor-targeted therapeutic strategy to lower arrhythmia risk in heart failure.
Hegyi B, Angsutararux P, Chakouri N et al. · Circulation research · (2026) · 1 citations · View on PubMed ↗ · Free PDF ↗
Integrative network and structural analysis of Pinus derived phytosterols in diabetes associated pathways.
This in silico study examined two Pinus-derived phytosterols—β-sitosterol and 24-nor-cholest-5,22E-dien-3β-ol—for interactions with endocrine-related protein targets implicated in diabetes, using integrative network pharmacology and structural analysis. Network analysis identified ESR1, AR, SHBG, and CYP17A1 as central nodes in diabetes-associated endocrine resistance pathways. These computational findings suggest specific steroid-hormone axis targets that could be prioritized for future experimental validation of phytosterol-based diabetes therapeutics.
Ali PR, Sri GK, Sravanthi G et al. · In silico pharmacology · (2026) · View on PubMed ↗ · Free PDF ↗
Infectious/Inflammatory Systemic Disease & Pericardial Disease (e.g., Lyme) and Other Non-cardiac Themes
Frontiers in Ocular Therapy: Linking Nanoparticles to Patho- Therapeutic Outcomes in Keratitis Treatment.
This narrative review examined how nanoparticle-based ocular drug delivery could improve patho-therapeutic outcomes in keratitis caused by bacterial, fungal, or viral pathogens, focusing on limitations of conventional antimicrobials such as poor corneal bioavailability and rapid tear clearance. It found that nanotechnology approaches (e.g., improved delivery, targeting, and combination strategies) are promising to overcome these barriers and address drug resistance. The review’s significance is to guide future development of more effective, targeted anti-infective therapies for keratitis.
Tiwari R, G D, Mohan VK et al. · Recent advances in anti-infective drug discovery · (2026) · View on PubMed ↗
Prevention of arterial catheter-related bloodstream infections: current evidence and future directions.
This review synthesized current evidence and future directions for preventing arterial catheter-related bloodstream infections (AC-CRBSI) in patients requiring arterial catheters for hemodynamic monitoring and blood sampling. It identified that insertion and maintenance practices—despite limited AC-specific trials—include strategies analogous to central line prevention and that evidence is inconsistent and underdeveloped for arterial catheters. The clinical significance is to inform more standardized surveillance and to prioritize research to determine optimal AC-CRBSI prevention bundles.
Donner V, Sadeghi CD, Catho G et al. · Critical care (London, England) · (2026) · View on PubMed ↗ · Free PDF ↗
Association between CMR-derived pulmonary artery pulse wave velocity and pulmonary risk factors: the multi-ethnic study of atherosclerosis COPD study.
In the multi-ethnic MESA COPD prospective cohort, this study used cardiac magnetic resonance (CMR) with 2-D phase-contrast flow imaging to quantify pulmonary artery pulse wave velocity (PA-PWV) and tested associations with pulmonary risk factors, particularly smoking history. PA-PWV measured in the main, right, and left pulmonary arteries (using validated semi-automated software) showed relationships with smoking exposure, indicating that pulmonary arterial stiffness can reflect pulmonary risk in this population. These results support PA-PWV as a potentially useful CMR-derived marker for pulmonary vascular risk stratification in COPD-related settings.
Huurman R, Xie E, Ohyama Y et al. · Magnetic resonance imaging · (2026) · View on PubMed ↗
Transcriptomic characterization of Coccidioides morphological states using RiboMarker-enhanced RNA sequencing.
This study characterized small RNA (sRNA) and transcriptomic differences across three Coccidioides posadasii morphologies—arthroconidia, mycelia, and spherules—using RiboMarker-enhanced RNA sequencing with separate intracellular and extracellular RNA fractions. By applying RiboMarker sRNA and RNA fragment library preparation, the authors achieved improved transcriptome coverage and profiled sRNA expression patterns associated with fungal life-stage transitions. The significance is that it expands understanding of sRNA-mediated regulation of virulence across Coccidioides morphological states, informing future targets for antifungal strategies.
Howard JM, Manning AC, Clark RC et al. · G3 (Bethesda, Md.) · (2026) · View on PubMed ↗ · Free PDF ↗
Elevated hydrostatic pressure promotes organic carbon mineralization in reservoir sediments.
The study examined how elevated hydrostatic pressure (0.1–2.1 MPa) affects organic carbon mineralization in reservoir sediments using a custom-built hydrostatic pressure simulation system with non-sterilized sediment–water incubations. Increasing pressure significantly accelerated sediment organic carbon mineralization, with the apparent carbon mineralization rate at 2.1 MPa reported as 1.45-, 2.01-, and 1.72-fold higher than lower-pressure conditions. These findings suggest that reservoir-induced pressure changes can enhance microbial-driven carbon loss, improving predictions of carbon cycling and biogeochemical impacts of damming.
Zhang Y, Xiao S, Liu D et al. · Water research · (2026) · View on PubMed ↗
Lyme Myopericarditis With Effusive-Constrictive Physiology: Serial CMR Identifies a Reversible Inflammatory Phenotype.
This 45-year-old man with Lyme disease developed myopericarditis with effusive-constrictive physiology, and serial cardiac magnetic resonance (CMR) was used to distinguish inflammatory from fixed constrictive physiology. The case demonstrated a reversible inflammatory phenotype on serial CMR after initial treatment for acute pericarditis, despite persistent symptoms and new left ventricular systolic dysfunction. Clinically, this supports using serial CMR to guide management decisions in Lyme-associated pericardial disease where treatment hinges on whether constriction is inflammatory and potentially reversible.
Alhirtani N, Bigham G, Fabrizio C et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗
The burden of ovarian cancer attributable to occupational asbestos exposure in Asia from 1990 to 2021: an analysis of the global burden of disease study 2021.
Using Global Burden of Disease Study 2021 data, this analysis quantified ovarian cancer (OC) deaths and disability-adjusted life years (DALYs) attributable to occupational asbestos exposure across Asian countries from 1990 to 2021. The study characterized the regional and temporal trends in age-standardized and crude OC burden linked to asbestos exposure. Scientifically and for public health, it strengthens evidence for asbestos as a modifiable occupational carcinogen and helps target prevention and surveillance strategies in Asia.
Yu Y, Zhang W, Deng T et al. · Tropical medicine and health · (2026) · View on PubMed ↗ · Free PDF ↗
Generated automatically on July 10, 2026. Covers PubMed articles published July 03, 2026 – July 10, 2026. Summaries are AI-generated; always consult the original publication for clinical or research decisions.