What's New in Cardiac MRI? — July 30, 2026
AI-summarised digest of 39 PubMed articles on Cardiac MRI published in the last 7 days.
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What’s New in Cardiac MRI?
July 30, 2026 · 39 articles · 15 research themes · covering July 23, 2026 – July 30, 2026
Overview
Across this week’s set, a dominant theme is the push to make advanced cardiovascular imaging more accurate, faster, and safer in real-world clinical contexts. Multiple studies focus on cardiac MRI acquisition and interpretation improvements—such as pregnancy-adapted protocols to avoid misclassification of physiologic changes, rapid single-shot dark-blood LGE for robust scar detection, and the establishment of demographic- and segment-specific native T1/T2 reference values to distinguish normal variation from pathology. Complementing this, systematic evidence reviews highlight where imaging surrogates remain imperfect (e.g., TTE-derived epicardial adipose tissue vs CT/MRI), and where specific biomarkers (like LGE in peripartum cardiomyopathy) may help risk stratify patients.
A second major thread is quantitative hemodynamics and remodeling biomarkers derived from MRI. Phase-contrast and 4D flow approaches are used to characterize age-related aortic remodeling, intracardiac flow remodeling in athletes, and exercise-related pulmonary vascular physiology relevant to right-ventricular decompensation. In parallel, methodological work (including unsupervised 4D flow reconstruction without manual segmentation and deep learning artifact suppression for real-time CMR) aims to reduce workflow variability and improve physical consistency—key steps toward scaling quantitative MRI beyond specialized centers.
Finally, several articles connect imaging to mechanism and outcomes through AI, electrophysiology, and therapeutics. Imaging-informed arrhythmia strategies (e.g., MRI-derived VT substrate corridors aligned with electroanatomical mapping; anatomy-guided PVC ablation) and AI tools for ECG triage and digital-twin electrophysiology illustrate a broader move toward personalized risk assessment. Meanwhile, mechanistic trials and translational studies use CMR endpoints to test cardioprotective therapies (e.g., SGLT2 inhibitors post-AMI) and safer regenerative approaches (cell therapy designed to avoid ventricular arrhythmias), while autoimmune disease reviews synthesize how heterogeneous, often subclinical cardiac involvement can be phenotyped with multimodality imaging.
Cardiac MRI in Pregnancy & Special Populations
Comprehensive Cardiac Assessment and Assisted Reproductive Technology Considerations in a Long-Lost Patient With Fontan Circulation.
This case study evaluated cardiovascular status and pregnancy/assisted reproductive technology (ART) risk in a 29-year-old woman with Fontan physiology due to tricuspid atresia palliated with a 22-mm extracardiac Fontan. Multimodal assessment using right heart catheterization, cardiac magnetic resonance, ambulatory monitoring, stress echocardiography, and labs found a well-compensated Fontan without high-risk features, supporting prophylactic anticoagulation with enoxaparin (details truncated). The report highlights how structured hemodynamic/thrombotic risk stratification can inform safer ART planning in adults with Fontan circulation.
O’Very SA, Shook JE, DeZorzi CJ · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗
How to Use Cardiovascular Imaging in Pregnancy.
This review studied how cardiovascular imaging modalities (e.g., echocardiography, CMR, and CT) should be used in pregnant patients with suspected or established cardiovascular disease. It found that pregnancy-related physiologic changes (increased blood volume and cardiac output with chamber remodeling) require pregnancy-adapted acquisition protocols and careful distinction between normal and pathological imaging findings. This is clinically significant because it provides a practical framework to improve diagnostic accuracy and longitudinal risk stratification during pregnancy while minimizing misinterpretation.
Van Berendoncks A, Rodriguez Palomares J, De Backer J · Circulation. Cardiovascular imaging · (2026) · View on PubMed ↗
Cardiac MRI Tissue Characterization (T1/T2/LGE) & Reference Standards
Age-, sex-, and segment-specific myocardial T1 and T2 reference values in a healthy cohort: a prospective single-center study.
This prospective single-center study measured age-, sex-, and segment-specific native myocardial T1 and T2 reference values in 183 healthy Caucasian participants using 3T CMR with Modified Look-Locker Inversion-Recovery (MOLLI) for T1 and a standardized T2 mapping approach. The key finding was that reference values vary by demographic factors and myocardial segments, and the authors provided standardized, clinically feasible breath-hold protocols and segment-based reference ranges. This is important for improving diagnostic accuracy when distinguishing normal variation from myocardial pathology in routine CMR.
Körperich H, Shanmugarajah N, Schneider A et al. · Clinical research in cardiology : official journal of the German Cardiac Society · (2026) · View on PubMed ↗ · Free PDF ↗
Cardiac Magnetic Resonance-Derived Parametric Mapping Radiomics for Prediction of Left Ventricular Reverse Remodeling in Patients With Dilated Cardiomyopathy.
This retrospective study assessed whether cardiac magnetic resonance (CMR) parametric mapping radiomics can predict left ventricular reverse remodeling (LVRR) in 74 patients with nonischemic dilated cardiomyopathy treated with optimized medical therapy. Radiomic scores (RadScores) derived from high-dimensional features of parametric mapping images were tested against LVRR defined as LVEF ≥40% with ≥10% increase at least 180 days after CMR. If validated, CMR radiomics could enable earlier, noninvasive prediction of which patients will achieve LVRR and thus refine prognosis and treatment selection in nonischemic dilated cardiomyopathy.
Ide S, Ohtani T, Takao T et al. · Journal of the American Heart Association · (2026) · View on PubMed ↗ · Free PDF ↗
Prognostic value of late gadolinium enhancement in peripartum cardiomyopathy: a systematic review and meta-analysis.
This systematic review and meta-analysis evaluated whether late gadolinium enhancement (LGE) on cardiac magnetic resonance predicts outcomes in peripartum cardiomyopathy (PPCM). Across included studies, LGE was assessed for associations with reduced LVEF, arrhythmia, heart failure decompensation, device implantation, transplantation, and mortality (pooled hazard ratios calculated; results truncated). The findings are clinically important because LGE could serve as a risk stratification biomarker to guide monitoring and management in PPCM.
Nurhafizah A, Huang W, Kezia C et al. · Future cardiology · (2026) · View on PubMed ↗
Single-shot blood-nulled PSIR LGE with fixed inversion time for rapid and reliable scar detection in cardiac MRI.
This prospective single-center study compared segmented white-blood late gadolinium enhancement (LGE) versus single-shot dark-blood (DB) LGE using a fixed inversion time (TI=160 ms) in patients with suspected ischemic or non-ischemic cardiomyopathy undergoing 1.5 T cardiac MRI. The key finding was that fixed-TI single-shot DB LGE enabled rapid, reliable myocardial scar detection and performed comparably to conventional segmented white-blood LGE for presence and localization of scar. This is scientifically and clinically significant because it supports faster, more robust scar imaging workflows that may improve CMR feasibility in routine practice.
Kübler J, Ledesma AJ, Holtackers RJ et al. · European journal of radiology · (2026) · View on PubMed ↗
Myocardial Native T1 Mapping in the German National Cohort (NAKO): Associations with Age, Sex, and Cardiometabolic Risk Factors.
This cross-sectional analysis studied associations between age, sex, and cardiometabolic risk factors with myocardial native T1 mapping in 29,573 participants from the German National Cohort (NAKO). The key finding was that cardiometabolic risk and demographic factors were associated with measurable differences in myocardial native T1, supporting native T1 as a marker of subclinical myocardial target-organ involvement. This is clinically significant because it links population-level risk profiles to quantitative CMR tissue characterization that may help identify early cardiac injury.
Ammann C, Gröschel J, Saad H et al. · Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · (2026) · View on PubMed ↗ · Free PDF ↗
Cardiac MRI Perfusion & Hemodynamic Quantification
Determinants of Abnormal Pulmonary Vasodilatory Response With Exercise in HFpEF: Pulmonary Vascular-Left Atrial Axis Abnormalities.
This study evaluated determinants of an abnormal pulmonary vasodilatory response with exercise in 164 participants undergoing invasive cardiopulmonary exercise testing, including 80 patients with HFpEF, 57 with pre-capillary pulmonary hypertension, and 27 with non-cardiac dyspnea. An unfavorable exercise PVR response (exercise PVR >1.74 Woods units and <22% ∆PVR decrease) was associated with pulmonary vascular–left atrial axis abnormalities and identified high-risk correlates for failure to appropriately reduce PVR during exertion. These findings improve risk stratification for right-ventricular decompensation in HFpEF and related pulmonary vascular disease by linking exercise hemodynamics to specific pulmonary vascular–left atrial physiology.
Garcia-Arango M, Kristo A, El Shaer A et al. · Comprehensive Physiology · (2026) · View on PubMed ↗ · Free PDF ↗
Impact of Rate-Pressure Product Correction of Myocardial Blood Flow on the Prognostic Relevance in Patients with Heart Failure.
This study evaluated whether correcting quantitative perfusion CMR–derived myocardial blood flow (MBF) for rate-pressure product (RPP) changes prognostic performance in patients with heart failure. In 641 heart failure patients and 184 healthy volunteers, resting MBF was RPP-corrected and myocardial perfusion reserve (MPR) was recalculated, with prognosis assessed using a composite endpoint including heart failure hospitalization and all-cause mortality (details truncated). If RPP correction improves risk stratification, it could standardize QP-CMR interpretation and strengthen prognostic use of perfusion metrics in heart failure.
Anderton T, Chambers B, Farooq M et al. · European heart journal. Cardiovascular Imaging · (2026) · View on PubMed ↗ · Free PDF ↗
Targeted Flow Cardiac MRI in Neonates with Intracardiac Shunts: A Novel Multi-Modality Imaging Approach to Hemodynamic Assessment.
This study investigated targeted flow cardiac MRI in neonates/infants with intracardiac shunts to non-invasively assess pulmonary-to-systemic flow ratio (Qp:Qs) using no, minimal, or baseline sedation. The key finding was that cardiac MRI could be implemented as a multi-modality hemodynamic approach to help distinguish contributions of pulmonary vascular resistance versus intracardiac shunts in infants with possible pulmonary hypertension. This is significant because it offers a less invasive, MRI-based pathway for hemodynamic assessment when echocardiography and clinical evaluation are insufficient.
Simpkin CT, Taylor AC, MacLean J et al. · The Journal of pediatrics · (2026) · View on PubMed ↗ · Free PDF ↗
Echocardiography vs CT/MRI Surrogates (Adipose/Other Biomarkers)
The Role of Echocardiography in the Assessment of Epicardial Adipose Tissue: A Systematic Review and Meta-analysis.
This systematic review and meta-analysis studied whether transthoracic echocardiography (TTE) can serve as a valid surrogate for epicardial adipose tissue (EAT) volumetric assessment compared with reference volumetric methods such as cardiac MRI and cardiac CT. The key finding was that the evidence base linking TTE-derived EAT measures to volumetric EAT quantification is incomplete and varies in disease-specific validity, limiting definitive conclusions about broader clinical utility. This is significant because it clarifies the current limitations of using echocardiography for preventive and longitudinal cardiometabolic risk assessment when CT/MRI are constrained.
Pala B, Piscione M, Cribari F et al. · Current obesity reports · (2026) · View on PubMed ↗ · Free PDF ↗
4D Flow & Phase-Contrast MRI Hemodynamics
Investigating Biventricular Intracardiac Flow Remodeling in Marathon Athletes With 4D Flow Cardiac MRI.
This study investigated biventricular intracardiac flow remodeling in marathon athletes using 4D flow cardiac MRI and assessed associations with markers of exercise-induced cardiac remodeling. The key finding was characterization of specific intracardiac flow components in athletes and their relationship to remodeling features that may mimic early cardiomyopathy. This matters scientifically because 4D flow MRI could provide hemodynamic biomarkers to distinguish physiologic athletic remodeling from early disease.
Tang M, Ren W, Liu G et al. · Journal of magnetic resonance imaging : JMRI · (2026) · View on PubMed ↗
Phase-contrast cardiac MRI assessment of aortic reservoir-flow coupling across adult age groups.
This single-center observational study assessed phase-contrast cardiac MRI measures of aortic reservoir-flow coupling across adult age groups (18–33, 34–60, and >60 years) using a 3.0 T Siemens MAGNETOM Skyra scanner. The key finding was that reservoir-flow coupling metrics differed across age strata, reflecting age-related aortic remodeling and changes in stroke-volume input and regional flow organization. This is significant because it supports phase-contrast MRI as a quantitative tool for characterizing age-associated alterations in aortic hemodynamics relevant to cardiovascular risk.
Lv J, Ye Y, Zeng T et al. · Biomedizinische Technik. Biomedical engineering · (2026) · View on PubMed ↗ · Free PDF ↗
AI/Deep Learning for Cardiac Imaging Reconstruction & Quantification
Rapid online deep artifact suppression for real-time spiral bSSFP CMR with blipped-CAIPI simultaneous multi-slice imaging at 1.5 T.
This MRI methods study evaluated rapid online deep artifact suppression for real-time spiral bSSFP cardiovascular magnetic resonance using blipped-CAIPI simultaneous multi-slice (SMS-2) at 1.5 T in 10 healthy volunteers. A 3D U-Net-based deep artifact suppression pipeline enabled online reconstruction of RT-SMS spiral bSSFP images, addressing limitations of iterative reconstructions that previously prevented real-time use. The technique is scientifically significant because it can shorten free-breathing CMR functional imaging while maintaining image quality for practical clinical workflows.
Åkesson J, Dragonu I, Heiberg E et al. · Magnetic resonance imaging · (2026) · View on PubMed ↗
High Resolution Isotropic ‘Pseudo’ 3D Cine imaging with Automated Segmentation using Concatenated 2D Real-time Imaging and Deep Learning.
This study developed a deep learning framework to generate isotropic “pseudo” 3D cine CMR by concatenating stacks of 2D free-breathing real-time cines and performing automated segmentation in pediatric and congenital heart disease contexts. Four deep learning models were trained to perform interslice signal correction, interslice respiratory correction, and slice-direction super-resolution (with additional segmentation components) to produce a fully segmented isotropic pseudo-3D cine dataset. The approach is clinically significant because it aims to combine the speed of real-time 2D imaging with the volumetric consistency needed for comprehensive assessment in children and patients with congenital heart disease.
Wrobel M, Yao T, Campbell R et al. · Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · (2026) · View on PubMed ↗
Patient-specific unsupervised neural reconstruction of cardiac blood flow from 4D flow MRI.
This methodological study introduced SMURF (Scalable Method for Unsupervised Reconstruction of Flow), an unsupervised neural reconstruction framework that infers probabilistic cardiac geometry and velocity fields directly from 4D flow MRI magnitude and phase data without manual segmentation or post hoc velocity filtering. In 12 pediatric 4D flow MRI cases (four normal and eight Fontan), SMURF produced reconstructions that matched expert segmentations and enabled consistent flow estimation on finer grids. The scientific significance is that it reduces workflow variability and improves physical consistency of cardiac blood flow quantification from 4D flow MRI.
Hans A, Singh A, Loke YH et al. · Medical image analysis · (2026) · View on PubMed ↗ · Free PDF ↗
AI/Computational Modeling & Digital Twins for Arrhythmia Risk
Body surface potential driven personalisation of electrophysiological digital twins in hypertrophic cardiomyopathy.
Researchers developed a body surface potential (BSP)-driven workflow to personalize electrophysiological digital twins in patients with hypertrophic cardiomyopathy (HCM) using electrocardiographic imaging (ECGI) and Bayesian model calibration. The key finding was that BSP data can be used to construct patient-specific ventricular electrophysiology models that better capture inter-patient heterogeneity in arrhythmia-relevant properties. This is significant because it provides a mechanistic, patient-specific framework that could improve arrhythmic risk assessment beyond standard ECG-based methods.
Malik S, Cicci L, Qayyum A et al. · PLoS computational biology · (2026) · View on PubMed ↗ · Free PDF ↗
Cardiac Arrhythmias & Electrophysiology (Imaging-Guided Ablation/Risk)
Clinical Characteristics of Multifocal PVCs Originating from the Basal Septal Region of the Left Ventricle: Anatomy, mapping and ablation.
This study characterized clinical features and developed a stepwise mapping and ablation approach for multifocal premature ventricular complexes (PVCs) originating from the basal septal region of the left ventricle in patients undergoing coronary venous mapping (CVM). In 24 patients with multifocal septal PVCs, ablation targeted the basal LV septum from the anterolateral LV ostium to the posterior LV process, leveraging the concept that morphologically diverse PVCs can arise from a confined anatomical substrate. The work is significant for improving procedural strategy and success rates in complex ventricular arrhythmias by using anatomy-guided mapping rather than morphology alone.
Gardziejczyk P, Tertulien T, Stuckey M et al. · Heart rhythm · (2026) · View on PubMed ↗
Structural and Functional Characteristics of Cardiac MRI-Detected Corridors in Ischemic Ventricular Tachycardia.
In 43 consecutive patients undergoing ischemic ventricular tachycardia (VT) ablation, the study correlated late gadolinium–enhanced cardiac MRI corridors identified with ADAS-3D software with electroanatomical mapping (EAM) substrate mapping using isochronal late activation mapping (ILAM). ADAS-3D–derived corridors showed relationships with mapped arrhythmogenic substrate and were evaluated as predictors of arrhythmogenicity and clinical outcomes after ablation. This is clinically important because MRI-derived substrate “corridors” could help refine VT risk stratification and ablation targeting in ischemic cardiomyopathy.
Dogan M, Coteli C, Aytemir K et al. · Pacing and clinical electrophysiology : PACE · (2026) · View on PubMed ↗
Specificity of the Occlusion Myocardial Infarction-Trained PMcardio “Queen of Hearts” AI-ECG in Inflammatory Myopericardial Syndromes.
This single-center retrospective study evaluated the ECG-level specificity of the occlusion myocardial infarction (OMI)-trained PMcardio “Queen of Hearts” AI-ECG model for OMI classification in emergency department patients with adjudicated inflammatory myopericardial syndromes (IMPS) from 2010–2025. The key finding was that the AI-ECG’s specificity for OMI classification in IMPS was quantified, addressing the risk of unnecessary catheterization laboratory activation when IMPS mimics OMI on ECG. This is clinically significant because it informs safe deployment of AI-ECG triage tools in inflammatory conditions that commonly confound standard ECG interpretation.
Bennar W, Garin D, Saidi RM et al. · JACC. Advances · (2026) · View on PubMed ↗ · Free PDF ↗
Congenital/Structural Heart Disease & Fetal/Neonatal Imaging
Topsy-Turvy Heart: Multimodality Prenatal and Postnatal Imaging for Clinical Management.
This JACC Case Reports article presented a prenatal and postnatal imaging strategy for a newborn diagnosed with topsy-turvy heart and an aortopulmonary window, emphasizing associated airway abnormalities. Using combined fetal echocardiography and fetal cardiac magnetic resonance, clinicians characterized complex intracardiac anatomy prenatally, but the infant developed severe respiratory failure requiring mechanical ventilation immediately after birth. The case supports multimodality fetal imaging to improve perinatal planning in extremely rare congenital heart disease with high risk of airway and respiratory complications.
Meyer D, Geiger J, Weber R et al. · JACC. Case reports · (2026) · View on PubMed ↗
Cardiomyopathy & Myocardial Remodeling (Including Exercise/Activity Effects)
The Relationship Between Physical Activity and Left Ventricular Remodeling in Childhood Cancer Survivors Treated With Anthracyclines: A Cross-Sectional Study.
This prospective observational cross-sectional study examined the relationship between moderate-to-vigorous physical activity (MVPA) and left ventricular remodeling in childhood cancer survivors treated with anthracyclines. Using accelerometry-derived MVPA and cardiovascular magnetic resonance measures of indexed LV mass (LVMi), LV end-diastolic volume (LVEDVi), mass:volume ratio, and LVEF, the study evaluated how activity and patient factors associate with remodeling (results truncated). Clinically, identifying activity–remodeling links could inform survivorship exercise recommendations to mitigate anthracycline cardiotoxicity.
Narayan HK, Chen S, Wong FL et al. · Pediatric blood & cancer · (2026) · View on PubMed ↗
Heart Failure Biomarkers & Prognostic Modeling
Left Ventricular Dimension as an Independent Factor Associated with Amino-Terminal pro-Brain Natriuretic Peptide Values in Heart Failure.
Using a multicenter retrospective dataset of 8,361 patients across acute (n=4,374) and chronic (n=3,987) heart failure cohorts, the study evaluated whether left ventricular end-diastolic diameter (LVEDD) is independently associated with circulating amino-terminal pro–brain natriuretic peptide (NT-proBNP) levels. The key finding was that LV dimension (LVEDD) independently correlated with NT-proBNP concentrations across the heart failure spectrum. This is significant because it refines interpretation of NT-proBNP by identifying a structural contributor that may affect biomarker levels and clinical assessment.
Núñez J, Lupón J, Jenkins FS et al. · The American journal of medicine · (2026) · View on PubMed ↗
Therapeutics & Mechanistic Trials Using CMR Endpoints
Deramiocel heart-derived cellular therapy in advanced Duchenne muscular dystrophy (HOPE-3): a phase 3, randomised, double-blind, placebo-controlled trial.
This phase 3, multicenter, randomized, double-blind, placebo-controlled trial studied deramiocel (human allogeneic cardiosphere-derived cells) in participants aged ≥10 years with advanced Duchenne muscular dystrophy. Deramiocel was tested for efficacy and safety to support prior HOPE-2 results, with outcomes assessed after intravenous infusion compared with placebo. If effective, this would provide a clinically actionable cell-therapy option targeting progressive skeletal and cardiac myopathy in a genetically defined DMD population.
McDonald CM, Villa C, Soslow JH et al. · Lancet (London, England) · (2026) · View on PubMed ↗
SGLT2 Inhibitor on Infarct Size and LV Remodeling by CMR in Patients With AMI.
This prospective, open-label randomized controlled trial enrolled adults ≥18 years at high risk for heart failure after successful percutaneous coronary intervention (PCI) for acute myocardial infarction (AMI) to test whether sodium-glucose cotransporter 2 (SGLT2) inhibitor therapy reduces infarct size and left ventricular (LV) remodeling assessed by cardiac MRI (CMR). The key finding was the effect of SGLT2 inhibitor treatment on CMR measures of myocardial injury and subsequent LV remodeling after AMI. The study is significant because it links a clinically used drug class to mechanistic CMR endpoints that may explain cardioprotection after AMI.
Choi KH, Lee SH, Kim SM et al. · JACC. Cardiovascular interventions · (2026) · View on PubMed ↗
Human Induced Pluripotent Stem Cell-Derived Committed Cardiac Progenitors Generate Cardiac Tissue Grafts in a Swine Ischemic Cardiomyopathy Model Without Triggering Ventricular Arrhythmias.
This preclinical study tested whether human induced pluripotent stem cell (hiPSC)-derived committed cardiac progenitor cells (CCPs) delivered by transendocardial injection, combined with cardiac fibroblast-derived extracellular matrix (cECM), can generate functional cardiac tissue grafts without ventricular arrhythmias in a swine ischemic cardiomyopathy model. The approach produced cardiac tissue grafts that improved contractility while avoiding ventricular arrhythmia triggering, addressing a key safety barrier seen with hiPSC-derived cardiomyocyte therapies. The findings support a potentially safer cell-therapy strategy for post–myocardial infarction repair in large-animal models.
Raval AN, Schmuck EG, Leonov V et al. · Journal of the American Heart Association · (2026) · View on PubMed ↗ · Free PDF ↗
Systemic Autoimmune Rheumatic Diseases & Cardiac Imaging Phenotypes
Imaging Modalities Related to Cardiac Involvement in Systemic Sclerosis.
This review article summarized imaging modalities relevant to cardiac involvement in systemic sclerosis (SSc), a disease driven by microvasculopathy, autoimmunity, and fibrosis. It discusses how different imaging techniques are used to detect and characterize SSc-related cardiac inflammation and fibrosis, as well as associated pulmonary vascular disease that contributes to morbidity and mortality. The review is significant for guiding clinicians in selecting appropriate imaging strategies to evaluate cardiac complications in a high-risk, predominantly female rheumatologic population.
Markousis-Mavrogenis G, Sfikakis PP, Matucci-Cerinic M et al. · Journal of the American Heart Association · (2026) · 1 citations · View on PubMed ↗ · Free PDF ↗
Cardiac Imaging Phenotypes in Systemic Inflammatory Disorders and Perspectives: What Have We Learned and Where Do We Need to Go Next?
This review examined cardiac imaging phenotypes across systemic autoimmune rheumatic diseases (SARDs) and summarized what is known about cardiovascular involvement detected by echocardiography, cardiac MRI, and other imaging modalities. It highlights that cardiovascular disease in SARDs is often subclinical and heterogeneous, and that imaging phenotyping could improve early detection, characterization, and monitoring. The work is significant because it frames a pathophysiology-driven agenda for future imaging studies to better translate SARD-related cardiac risk into clinical practice.
Buch MH, Plein S · Journal of the American Heart Association · (2026) · 1 citations · View on PubMed ↗ · Free PDF ↗
Rare Cardiac Complications (Case Reports) & Diagnostic Imaging
Post-traumatic pericarditis following penetrating injury to the heart: a case report.
This case report described post-traumatic pericarditis progressing to transient constrictive pericarditis in a 22-year-old man after a penetrating stab wound to both ventricles. Multimodal imaging was used to establish diagnosis and guide follow-up as inflammatory pericardial disease evolved after non-iatrogenic cardiac trauma. The report highlights the diagnostic value of multimodality imaging for recognizing rare post-cardiac injury syndromes and their potential constrictive physiology.
Ekhelikar S, Chukwudi I, Lewis G et al. · The international journal of cardiovascular imaging · (2026) · View on PubMed ↗
Inaugural complete heart block in anti-SSA negative systemic lupus erythematosus: the diagnostic role of anti-PM-Scl 100 antibodies.
This case report studied inaugural complete heart block in a 21-year-old woman with anti-SSA-negative systemic lupus erythematosus, focusing on diagnostic biomarkers. Despite negative anti-SSA/Ro, cardiac MRI and standard workup excluded common reversible causes, and the diagnostic emphasis was placed on anti-PM-Scl 100 antibodies (with microvascular assessment) as a key clue. The report is clinically significant because it broadens the antibody spectrum to consider when adult SLE presents with rare conduction disease.
Dammene Debbih N, Laouar L, Dekdouk N et al. · Lupus · (2026) · View on PubMed ↗
Familial arrhythmogenic cardiomyopathy presenting with aborted sudden cardiac arrest in an adolescent: a novel DSP variant.
This case report described a 15-year-old girl with aborted sudden cardiac arrest whose imaging suggested left-dominant arrhythmogenic cardiomyopathy and whose genetic testing identified a novel DSP (desmoplakin) variant. The key finding was that the identified DSP variant co-segregated with affected relatives on family screening, supporting a familial arrhythmogenic cardiomyopathy diagnosis. The clinical significance is that early genetic diagnosis and risk stratification can guide management, including cardioverter-defibrillator implantation, in adolescents at risk.
Marques AR, Novais Pimenta J, Grangeia A et al. · Cardiology in the young · (2026) · View on PubMed ↗
Rheumatoid arthritis and multisite cardiac aneurysms involving the LVOT, valves, and intervalvular Fibrosa: A case-based systematic review.
This case-based systematic review compiled reported instances of rheumatoid arthritis (RA)–associated aneurysmal or pseudoaneurysmal cardiac involvement affecting the left ventricular outflow tract (LVOT), valves, and intervalvular fibrosa. The key finding was that such RA-related aneurysmal complications are exceptionally rare and were characterized across clinical presentation, imaging findings, pathology, and therapies in the published cases. This is significant because it consolidates evidence to support earlier recognition and management of uncommon but potentially life-threatening RA cardiac complications.
Alberti M, Cito V, Capozza P et al. · Vascular pharmacology · (2026) · View on PubMed ↗
A 46-Year-Old Man Presenting With Chest Pain Due to Apical Hypertrophic Cardiomyopathy (Yamaguchi Syndrome) Diagnosed by Multimodal Cardiac Imaging.
This case report evaluated a 46-year-old man presenting with chest pain and giant negative T-waves on ECG, ultimately diagnosed with apical hypertrophic cardiomyopathy (ApHCM, Yamaguchi syndrome) using multimodal cardiac imaging. The key finding was that multimodal imaging supported ApHCM and excluded coronary occlusion/myocardial infarction despite ACS-like symptoms and ECG changes. The report underscores the diagnostic value of advanced imaging to differentiate rare ApHCM from acute coronary syndromes.
Passos MD, de Araújo DLM, Mariano LÁ et al. · The American journal of case reports · (2026) · View on PubMed ↗ · Free PDF ↗
Chronic draining xiphisternal fistula associated with fractured right coronary artery stent and transdiaphragmatic inflammatory extension: a multimodality imaging and surgical correlation.
This case report investigated a rare chronic coronary stent complication presenting as a draining xiphisternal fistula in a 53-year-old man with type 2 diabetes and ischemic heart disease. Multimodality imaging and surgical correlation linked the fistula to a fractured right coronary artery (RCA) stent with transdiaphragmatic inflammatory extension, explaining the delayed indolent course mimicking superficial infection. The report emphasizes the need for advanced imaging to diagnose and plan surgery for late, stent-related inflammatory fistulization.
Ansari ZR, Hamdulay ZA, Khan A et al. · The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology · (2026) · View on PubMed ↗ · Free PDF ↗
Exercise-Induced Ventricular Tachycardia Unmasking High-Risk Anomalous Right Coronary Artery in an Adult.
This JACC Case Reports study examined a 43-year-old physically active adult with exercise-induced symptoms to identify the cause of ventricular ectopy progressing to nonsustained ventricular tachycardia during recovery. Coronary CT angiography (CCTA) revealed a high-risk anomalous right coronary artery arising from the left sinus, unmasked by exercise stress testing. The significance is that it highlights adult presentation of AAOCA and supports exercise-triggered evaluation and CCTA confirmation to guide management and reduce sudden cardiac death risk.
Eisa A, Rashwan R, Aldarab’ah FM et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗
Non-Cardiac/Physics Methods (Imaging Physics/Materials) & Non-Cardiac Oncology
Evolving paradigms in lymph node surgery in endometrial cancer: insights from the multicenter E-PEC trial.
This multicenter retrospective E-PEC analysis studied temporal trends in lymph node surgery for newly diagnosed endometrial cancer in six German university hospitals from 2018 to 2022. The investigators characterized how lymph node staging approaches changed over time among patients undergoing primary surgical treatment (excluding those receiving primary systemic or chemoradiation therapy). These findings inform evidence-based surgical practice and may guide standardization of lymph node management in endometrial cancer.
Eser B, Papior D, Salmanton-García J et al. · Archives of gynecology and obstetrics · (2026) · View on PubMed ↗
Clinical Impact of Discordant Minimal Residual Disease Assessment in Adult Patients with Acute Lymphoblastic Leukemia Undergoing Allogeneic Hematopoietic Cell Transplantation.
This retrospective clinical study assessed how discordant measurable residual disease (MRD) results across multiparametric flow cytometry (MFC), next-generation sequencing (NGS), and BCR::ABL1 RT-qPCR affect outcomes in 182 adults with B-cell precursor acute lymphoblastic leukemia (B-ALL) undergoing allogeneic hematopoietic cell transplantation (allo-HCT). MRD was compared across paired timepoints (after remission induction, after consolidation, and pre-HCT) and correlated with clinical outcomes (results truncated). The work is significant because it addresses how inter-assay MRD discordance may complicate MRD-guided allo-HCT decisions in adult B-ALL.
Yoon JH, Jung J, Lee S et al. · Transplantation and cellular therapy · (2026) · View on PubMed ↗
Terahertz-Nanoscale Visualization of the Microscopic Spin-Charge Architecture of Colossal Magnetoresistive Switching.
This physics study used cryogenic cryogenic magneto-THz scattering-type scanning near-field optical microscopy (cm-THz-sSNOM) to visualize the microscopic spin-charge architecture during colossal magnetoresistive (CMR) switching in a terahertz regime. The key advance was achieving near-field THz spectroscopic resolution of the CMR transition at sub-10 nm scales while overcoming prior constraints of magnetic field control, cryogenic conditions, and nanometer resolution (details truncated). Scientifically, the work provides a pathway to directly probe THz electrodynamics of spin switching, informing fundamental limits and design of spin-electronic devices.
Haeuser S, Chan RK, Kim RHJ et al. · Advanced science (Weinheim, Baden-Wurttemberg, Germany) · (2026) · View on PubMed ↗ · Free PDF ↗
Eosinophilic gastrointestinal diseases.
This Nature Reviews Disease Primers article studied eosinophilic gastrointestinal diseases (EGID) across affected GI segments, including eosinophilic esophagitis, gastritis, enteritis, and colitis, and how to distinguish them from secondary causes of eosinophilia. It found that EGID is defined by prominent eosinophilic inflammation with segment-specific symptoms in the absence of secondary etiologies such as parasitic infection, medications, vasculitis, allergic syndromes, hematologic disorders, or other inflammatory diseases. This is significant because it provides an evidence-based diagnostic framework that guides clinicians toward appropriate evaluation and targeted therapy.
Lenti MV, Rossi CM, Dellon ES et al. · Nature reviews. Disease primers · (2026) · View on PubMed ↗
Generated automatically on July 30, 2026. Covers PubMed articles published July 23, 2026 – July 30, 2026. Summaries are AI-generated; always consult the original publication for clinical or research decisions.