What’s New in Cardiac MRI?

August 02, 2026 · 92 articles · 15 research themes · covering July 26, 2026 – August 02, 2026

Overview

Across this week’s papers, a dominant theme is the rapid maturation of cardiac MRI from “image acquisition” toward “computational measurement.” Multiple studies use deep learning and advanced reconstruction (e.g., online artifact suppression, real-time acceleration, and encoder-focused segmentation architectures) to make CMR faster and more scalable—especially for free-breathing, pediatric, and complex workflow settings. Complementing this, several efforts standardize or automate downstream quantification (e.g., fibrosis mapping to universal coordinates, cine-derived coupling metrics, and AI-assisted volumetrics from 4D flow), aiming to reduce variability and improve comparability across sites and time.

A second major thread is risk stratification using more specific tissue and microvascular signatures rather than relying on single global measures. Studies link CMR-derived fibrosis patterns (including specialized entities like papillary muscle fibrosis and border-zone conduction features) and microvascular injury (persistent vs transient MVO; angiography-derived microcirculatory resistance) to prognosis after STEMI and in arrhythmia-prone conditions. Parallel work in inflammatory and immune-mediated disease (systemic sclerosis, lupus, eosinophilic myocarditis, post-cardiac injury syndromes) emphasizes that multimodality imaging and careful differential diagnosis can prevent misclassification—particularly when imaging mimics other cardiomyopathies or when serologies are atypical.

Finally, the digest highlights a translational push: consensus statements and protocol innovations for athletes and for contrast-free/free-breathing imaging; clinical trials testing immune- or cardiometabolic strategies in CMR-defined phenotypes (with at least one neutral result in post-COVID inflammatory cardiac involvement); and broader public-health and epidemiologic analyses that contextualize cardiovascular risk across populations. Together, these studies point toward a future where imaging is not only diagnostic, but also mechanistic, prognostic, and operationally optimized for real-world care.

---

AI & Deep Learning for Cardiac MRI Reconstruction/Segmentation

Automated whole-heart volumetrics and haemodynamics from 4D flow CMR magnitude images: development and validation of a deep learning model.

This study developed and validated a deep learning model to automate whole-heart volumetrics and hemodynamics from 4D flow CMR magnitude images. In 40 prospectively enrolled patients from the PREFER-CMR registry, the model’s anatomical accuracy was validated against standard cine imaging, with the goal of enabling faster segmentation and analysis from time-resolved 3D anatomical information inherent to 4D flow magnitude images, but the provided abstract is truncated before performance metrics are reported. If validated, this AI approach could reduce post-processing time and improve scalability of 4D flow CMR in clinical and research settings.

Gall A, Grafton-Clarke C, Li R et al. · European heart journal. Imaging methods and practice · (2026) · View on PubMed ↗ · Free PDF ↗

Pre-Imaging Clinical Factors Associated With Cardiac MR Image Quality Using Large Language Model-Enabled Data Extraction.

This retrospective study tested whether pre-imaging clinical information extracted using a large language model (LLM) is independently associated with cardiac MR image quality. Using 1,006 adult patients undergoing clinical cardiac MR (1.5 T and 3 T; cine, black blood, MR angiography, and/or late gadolinium enhancement protocols), image quality was categorized by radiologist reporting conventions into excellent, slightly limited, severely limited, or nondiagnostic. If validated, LLM-derived pre-scan factors could enable earlier identification of patients at risk for poor image quality and reduce repeat examinations.

Yu H, Bondarenko M, Nowroozi A et al. · Journal of magnetic resonance imaging : JMRI · (2026) · 1 citations · View on PubMed ↗ · Free PDF ↗

Dynamic Mode Decomposition (DMD) for Low-Latency Real-Time Cardiac MRI.

The study applied dynamic mode decomposition (DMD) to enable low-latency online reconstruction for 2D real-time cardiac MRI using spiral balanced steady-state free precession (bSSFP) in 10 healthy adults and 6 pregnant participants. DMD reconstruction was assessed against off-line spatiotemporally constrained reconstruction (STCR) and tested at two temporal resolutions, demonstrating feasibility for real-time cardiac imaging with reduced latency. This supports DMD as a computational acceleration technique for real-time cardiac MRI, potentially improving workflow and image availability in both adult and fetal/pregnancy settings.

Yagiz E, Tasdelen B, Ozaslan IK et al. · Magnetic resonance in medicine · (2026) · View on PubMed ↗ · Free PDF ↗

R3Net: Recursive Residual Refinement Network Architecture for Decoder-Free Medical Image Segmentation.

This paper studied R3Net, a recursive residual refinement network architecture for decoder-free medical image segmentation, focusing on improving efficiency by strengthening the encoder without an explicit decoder. R3Net recursively reuses encoder stages and progressively fuses multiscale features via residual pathways to reconstruct high-resolution segmentation features while reducing architectural redundancy. If validated across benchmarks, this approach could lower compute and parameter costs for medical segmentation models used in clinical imaging pipelines.

Huang J, Zhao Y, Li Y et al. · Precision radiation oncology · (2026) · View on PubMed ↗

Rapid online deep artifact suppression for real-time spiral bSSFP CMR with blipped-CAIPI simultaneous multi-slice imaging at 1.5 T.

This technical study investigated rapid online deep artifact suppression to enable real-time spiral bSSFP cardiovascular MRI using blipped-CAIPI simultaneous multi-slice (SMS) imaging at 1.5 T. Using a spiral bSSFP RT sequence with SMS-2 and a 3D U-Net-based deep artifact suppression pipeline, the method was tested in 10 healthy volunteers for prospectively acquired real-time imaging. The significance is that it advances online reconstruction for fast free-breathing CMR, potentially reducing scan time while maintaining functional assessment capability.

Åkesson J, Dragonu I, Heiberg E et al. · Magnetic resonance imaging · (2026) · View on PubMed ↗ · Free PDF ↗

High Resolution Isotropic ‘Pseudo’ 3D Cine imaging with Automated Segmentation using Concatenated 2D Real-time Imaging and Deep Learning.

This study developed and trained four deep learning models to concatenate stacks of free-breathing 2D real-time balanced steady-state free precession (bSSFP) cine images into an isotropic, fully segmented “pseudo” 3D cine dataset for cardiovascular magnetic resonance (CMR), targeting pediatric and congenital heart disease imaging workflows. The key finding was that automated interslice signal correction, interslice respiratory correction, and slice-direction super-resolution enabled generation of an isotropic pseudo-3D cine with full segmentation from real-time 2D acquisitions. This approach could reduce reliance on breath-holds and respiratory navigation while improving 3D functional assessment and segmentation consistency in children and patients with congenital heart disease.

Wrobel M, Yao T, Campbell R et al. · Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · (2026) · View on PubMed ↗ · Free PDF ↗

---

Advanced CMR Tissue Characterization & Biomarkers (Fibrosis/Inflammation/Edema)

Clinical Applications of Cardiac Diffusion MRI: A Scoping Review.

This scoping review summarized clinical applications and emerging trends of cardiac diffusion MRI in in vivo human studies, focusing on diffusion-weighted imaging (DWI) and related techniques such as cardiac diffusion tensor imaging and intravoxel incoherent motion. Using systematic searches of Ovid MEDLINE, Embase, and Cochrane Library through March 2025 and extracting technique and application details, the key finding is a characterization of the breadth of diffusion MRI uses and how the field is evolving, but the abstract text provided is truncated before specific application categories are enumerated. Scientifically, this helps map where diffusion MRI is already clinically relevant and where evidence gaps remain for future trials.

Vora N, Cook M, Harper L et al. · Radiology. Cardiothoracic imaging · (2026) · View on PubMed ↗

Three-dimensional Mapping of Fibrosis Distribution in Desmoplakin Cardiomyopathy from Cardiac MRI.

This retrospective cardiac MRI study mapped late gadolinium enhancement (LGE) fibrosis onto universal ventricular coordinates in patients with desmoplakin cardiomyopathy across mild, moderate, and severe disease. The authors generated high-resolution 3D fibrosis distribution maps that allow spatial characterization of fibrotic patterns within a common ventricular reference framework. These fibrosis “atlases” could improve risk stratification and monitoring by standardizing how myocardial scar is quantified and compared across patients and severity levels.

Jilberto J, McManus B, Moghrabi A et al. · Radiology. Cardiothoracic imaging · (2026) · View on PubMed ↗

Papillary muscle fibrosis on cardiac magnetic resonance imaging: a pictorial review of causes, diagnostic challenges and practical pearls.

This pictorial review summarized causes and diagnostic pitfalls of papillary muscle fibrosis (PMF) on cardiac MRI and provided practical guidance for recognizing it. The key finding was that PMF is increasingly linked to ventricular arrhythmias but can be overlooked—particularly when papillary muscle and blood pool have similar late gadolinium enhancement (LGE) signal intensity. Clinically, improved detection of PMF on CMR can support more accurate diagnosis and arrhythmia risk assessment across ischemic and non-ischemic cardiomyopathies.

Gutierrez M, McCreavy D, Radike M · Clinical radiology · (2026) · View on PubMed ↗

Hypertension and myocardial fibrosis: A systematic review and meta-analysis.

This systematic review and meta-analysis evaluated how hypertension and antihypertensive therapy relate to myocardial fibrosis (MF) in observational and interventional studies, using histology and cardiac MRI measures such as extracellular volume fraction (ECV%) and native T1. The key finding was that hypertension is associated with greater myocardial fibrosis burden across included imaging and histological studies, with blood pressure and treatment-related factors contributing to the relationship. Clinically, the findings reinforce hypertension as a modifiable driver of cardiac remodeling and support using cardiac MRI or histology-derived fibrosis endpoints to refine cardiovascular risk in hypertensive populations.

Jiang J, Deng J, Dong L et al. · Clinical radiology · (2026) · View on PubMed ↗ · Free PDF ↗

Cardiac MRI unveils the hidden storm: Myocarditis-induced ventricular tachycardia in a young patient with a structurally normal heart.

This case report described a 37-year-old previously healthy man presenting with hemodynamically unstable ventricular tachycardia and elevated troponin but normal coronary arteries and preserved left ventricular systolic function on echocardiography. The key finding was that cardiac MRI revealed subepicardial late gadolinium enhancement and myocardial edema, confirming acute myocarditis as the arrhythmogenic substrate. The significance is that cardiac MRI can uncover myocarditis in young patients with structurally normal hearts, guiding appropriate management of malignant ventricular arrhythmias.

Alkhanafsa M, Aloqaily M, Ababneh R et al. · Radiology case reports · (2026) · View on PubMed ↗ · Free PDF ↗

Quantitative native T1 mapping identifies papillary muscle and intracavitary cardiac lipomas: A multiparametric CMR case series.

This multiparametric CMR case series reported two cardiac lipoma cases—a papillary muscle lipoma in a 47-year-old woman and an intracavitary left ventricular lipoma in a 31-year-old Asian man—using quantitative native T1 mapping. The key finding was that native T1 mapping showed markedly reduced T1 values (250 ms and 405 ms at 1.5 T, respectively) that supported lipoma diagnosis when conventional sequences could leave uncertainty. Scientifically, native T1 mapping may improve differentiation of intracardiac lipomas from other masses in anatomically complex or small lesions.

Montatore M, Rella M, Milo M et al. · Radiology case reports · (2026) · View on PubMed ↗ · Free PDF ↗

Radiation-Induced Acute Cardiac Injury in Patients With Left-Sided Breast Cancer: A Cardiac Magnetic Resonance Study on the Dose-Response Relation.

The study prospectively assessed radiation-induced acute cardiac injury using CMR strain analysis in 64 postoperative patients with left-sided breast cancer undergoing radiotherapy (RT), with cardiac dose calculated for dose-response evaluation. After RT, CMR strain metrics were used to characterize acute injury patterns in relation to radiation exposure to cardiac structures (whole-breast RT vs other regimens). This provides early, imaging-based evidence for how RT dose relates to acute myocardial dysfunction, informing surveillance and risk mitigation strategies in breast cancer patients.

Zheng L, Yang M, Luo C et al. · International journal of radiation oncology, biology, physics · (2026) · View on PubMed ↗ · Free PDF ↗

---

CMR Functional Imaging & Motion/Dyssynchrony Metrics

Impact of Left and Right Bundle Branch Block on Left Ventricular Systolic Function and Myocardial Mechanics Assessed by Speckle-Tracking Echocardiography and Cardiac Magnetic Resonance Feature Tracking: A Systematic Review and Meta-Analysis.

This systematic review and meta-analysis assessed how left bundle branch block (LBBB) and right bundle branch block (RBBB) affect left ventricular systolic function and myocardial mechanics measured by speckle-tracking echocardiography (STE) and cardiac magnetic resonance feature tracking (CMR-FT). The key finding is that bundle branch conduction abnormalities are associated with ventricular dyssynchrony and impaired myocardial mechanics beyond conventional left ventricular ejection fraction (LVEF), with the meta-analysis synthesizing deformation abnormalities for LBBB versus RBBB. Clinically, this supports using STE/CMR-FT to detect subclinical dysfunction in patients with conduction disease and to refine risk stratification.

Sonaglioni A, Lombardo M, Gramaglia GF et al. · Echocardiography (Mount Kisco, N.Y.) · (2026) · View on PubMed ↗

Effects of a Fasting-mimicking Diet on MRI-assessed Cardiac Structure and Function in Participants with Type 2 Diabetes.

This secondary analysis of the prospective Fasting In diabetes Treatment (NCT03811587) randomized trial studied whether a monthly 5-day fasting-mimicking diet (FMD) for 12 months changes cardiac structure and function in adults with type 2 diabetes (T2D). Using 3.0T cardiac MRI at baseline, 6 months, and 12 months (2D cine for LV geometry/systolic function and 4D flow MRI for diastolic function), the study tests FMD effects on LV geometry and function, but the provided abstract is truncated before reporting the primary results. If the full results show benefit, FMD could represent a non-pharmacologic strategy to improve MRI-measured cardiac remodeling in T2D.

Chen R, Westenberg JJM, van den Burg EL et al. · Radiology. Cardiothoracic imaging · (2026) · View on PubMed ↗

Association between Cardiac MRI-derived Global Longitudinal Strain and Clinical Outcomes in Chronic Aortic Regurgitation.

This multicenter retrospective study examined prognostic value of cardiac MRI-derived left ventricular global longitudinal strain (LV GLS) in patients with isolated chronic moderate-to-severe aortic regurgitation (AR). Using cine MRI with feature tracking to measure LV volumes, LVEF, and LV GLS, the key outcome was all-cause death or heart failure-related hospitalization, with multivariable Cox regression used for analysis, but the abstract text provided is truncated before the hazard results are shown. If LV GLS independently predicts outcomes, it would support incorporating strain by cardiac MRI feature tracking into risk assessment for chronic AR beyond LVEF.

Hashimoto G, Enriquez-Sarano M, Koike H et al. · Radiology. Cardiothoracic imaging · (2026) · View on PubMed ↗

Apical hypercontractility mitigates impaired diastolic filling and lower intraventricular haemodynamic forces in human bed rest.

This longitudinal experimental physiology study used cardiac MRI in 24 healthy participants to assess how 60 days of strict head-down tilt bed rest (AGBRESA) affects left ventricular diastolic filling and intraventricular haemodynamic forces, focusing on the role of apical hypercontractility. The key finding was that apical hypercontractility mitigated impaired diastolic filling and reduced intraventricular haemodynamic forces during bed rest. These results are scientifically significant because they identify a compensatory regional contractility mechanism that may help preserve cardiac function early during physical inactivity.

Rabineau J, Al-Darwish F, Mulder E et al. · Experimental physiology · (2026) · View on PubMed ↗ · Free PDF ↗

Quantitative Assessment of Myocardial Velocity and Dyssynchrony in Fontan Circulation Using MR Tissue Phase Mapping.

This prospective study used MR tissue phase mapping (TPM) to quantify myocardial velocity and dyssynchrony in the functional ventricle of 28 Fontan patients compared with 42 matched normal controls. The key finding was that TPM-derived velocity metrics (including peak velocities and time-to-peak in longitudinal, radial, and circumferential directions) and dyssynchrony indices differed in Fontan physiology and related to cardiac function. This is clinically significant because TPM provides a quantitative, voxel-wise motion assessment that may help evaluate mechanical dysfunction and guide follow-up in Fontan circulation.

Lu XZ, Weng KP, Wu MT et al. · NMR in biomedicine · (2026) · View on PubMed ↗

Prognostic Value of a Cardiac Magnetic Resonance-Derived Left Atrioventricular Coupling Index From Routine Cine Images in Dilated Cardiomyopathy: A Multicenter Study.

This multicenter retrospective study analyzed 403 patients with dilated cardiomyopathy (DCM) to determine whether a cardiac MRI-derived left atrioventricular coupling index (LACI) from routine cine images predicts adverse outcomes and adds value beyond conventional markers. The key finding was that LACI had prognostic utility for DCM outcomes and provided incremental risk stratification beyond measures such as left ventricular ejection fraction (LVEF) and late gadolinium enhancement (LGE). Clinically, this supports using a cine-derived CMR metric to improve risk prediction and potentially guide follow-up intensity in DCM.

Jiang YJ, Hou XC, Tao J et al. · Journal of magnetic resonance imaging : JMRI · (2026) · 1 citations · View on PubMed ↗ · Free PDF ↗

Left ventricular global longitudinal strain improves risk stratification in chronic aortic regurgitation.

This retrospective cohort study assessed whether cardiac magnetic resonance feature tracking-derived left ventricular global longitudinal strain (FT-LVGLS) improves risk stratification in 385 patients with chronic moderate-to-severe aortic regurgitation (AR) and minimal/no symptoms. FT-LVGLS was evaluated for association with adverse outcomes and for incremental prognostic value beyond the 2025 ESC/EACTS Class I/IIb surgical indication parameters. If confirmed, FT-LVGLS could refine timing of intervention and risk prediction in chronic AR by capturing subtle LV dysfunction not reflected in guideline criteria alone.

Li B, Liu Y, Dai L et al. · European heart journal. Cardiovascular Imaging · (2026) · 1 citations · View on PubMed ↗

Integrated Left Ventricular Mass and Left Atrial Function for Prediction of Cardiovascular Outcomes: The Multi-Ethnic Study of Atherosclerosis (MESA).

This analysis of Multi-Ethnic Study of Atherosclerosis (MESA) participants used CMR from Exam 1 (2000–2002) and Exam 5 (2010–2012) to test whether a CMR-derived LV mass-to-left atrial (LA) strain ratio predicts cardiovascular outcomes. The key finding was that the LV mass-to-LA strain ratio identifies early atrioventricular mechanical uncoupling/atrial myopathy and predicts subsequent cardiovascular events. Clinically, this provides a CMR-based composite metric that may detect risk earlier than using LV mass or LA strain alone.

Salameh E, Hoballah M, Ebrahimihoor E et al. · American journal of physiology. Heart and circulatory physiology · (2026) · View on PubMed ↗

---

CMR Vascular Imaging (Aorta/PWV/Distensibility/4D Flow)

Four-dimensional flow CMR-based hemodynamic assessment of ALCAPA: A case report.

This case report used contrast-free four-dimensional flow cardiac magnetic resonance (4D flow CMR) to characterize coronary anatomy and hemodynamics in a patient with anomalous left coronary artery from the pulmonary artery (ALCAPA). Maximum intensity projection from 4D flow CMR demonstrated right coronary artery dilation and the anomalous left coronary ostium arising from the pulmonary artery. The findings suggest 4D flow CMR can noninvasively clarify ALCAPA pathophysiology and help guide treatment planning.

Oka H, Nakau K, Shibagaki Y et al. · Radiology case reports · (2026) · View on PubMed ↗ · Free PDF ↗

Associations between cardiovascular risk factors and diseases with aortic pulse wave velocity and aortic distensibility: magnetic resonance imaging in the Hamburg city health study.

The study investigated associations between cardiovascular risk factors/diseases and cardiovascular magnetic resonance (CMR)-derived aortic pulse wave velocity (PWV) and aortic distensibility (AD) in the population-based Hamburg City Health Study (HCHS) cohort. Using 2D phase-contrast-flow CMR to quantify PWV and AD in the ascending and descending aorta, the authors related these vascular measures to prevalent cardiovascular risk profiles in 2270 participants (median age 66.5 years, 41.5% female). These results support CMR vascular biomarkers as potential tools for population-level cardiovascular risk stratification.

Riedl KA, Di Carluccio E, Huellebrand M et al. · Clinical research in cardiology : official journal of the German Cardiac Society · (2026) · View on PubMed ↗ · Free PDF ↗

---

Cardiac Imaging for Cardiomyopathies & Genetic Disease

Cardiac characteristics of Chinese patients with Danon disease associated with LAMP2 p.Leu325fs variants.

This retrospective clinical-genetic study characterized cardiac features in nine Chinese patients with Danon disease carrying the LAMP2 frameshift variant p.Leu325fs (resulting in premature termination and loss of functional LAMP2 protein). The key finding was the delineation of the specific cardiac phenotype associated with the p.Leu325fs variant, linking lysosomal dysfunction from LAMP2 loss to clinical cardiac manifestations. This improves genotype–phenotype understanding and may support more precise prognosis and management for patients with this specific LAMP2 variant.

Yin K, Li Y, Zhao H et al. · International journal of cardiology. Heart & vasculature · (2026) · View on PubMed ↗ · Free PDF ↗

Cardiac magnetic resonance tissue characterization in endurance athletes with paroxysmal atrial fibrillation phenotype (PAFIYAMA).

This observational cross-sectional study investigated cardiac magnetic resonance (CMR) tissue characterization in endurance athletes with a paroxysmal atrial fibrillation phenotype (PAFIYAMA) to determine whether myocardial fibrosis or diffuse abnormalities underlie the phenotype. Among 63 competitive male endurance athletes (PAFIYAMA n=22; controls n=41), participants underwent CMR including late gadolinium enhancement (LGE) assessment to characterize myocardial substrate. Identifying the myocardial abnormalities associated with PAFIYAMA is important for understanding AF mechanisms in athletes and for refining risk stratification and future interventions.

Garatachea N, Echevarría-Polo M, Hernández-Vicente A et al. · International journal of cardiology · (2026) · View on PubMed ↗ · Free PDF ↗

Disease penetrance and phenotypic spectrum of desmoplakin variant carriers in the population.

This population-based study assessed prevalence and phenotypic penetrance of desmoplakin (DSP) variants in 200,580 UK Biobank participants with exome sequencing, stratifying variants by predicted deleteriousness (pDel), predicted loss of function (pLOF), and ClinVar (ClinV). DSP variant carriers showed measurable disease penetrance with an arrhythmogenic cardiomyopathy phenotypic spectrum that may be underdetected by existing diagnostic criteria. These penetrance estimates can improve risk prediction and screening strategies for DSP-mediated arrhythmogenic cardiomyopathy in the general population.

Gurumoorthi M, Dabbagh GS, Wolfe R et al. · Heart rhythm · (2026) · View on PubMed ↗ · Free PDF ↗

Phenotype, genotype and prognosis of apical hypertrophic cardiomyopathies: a French multicentric cohort.

This French multicenter cohort study evaluated phenotype, genotype, and prognosis in 201 patients with apical hypertrophic cardiomyopathy (ApHCM) after excluding Fabry disease and amyloidosis, and compared them with 419 patients with non-apical HCM. Using echocardiography, cardiac magnetic resonance, genetic testing, and follow-up, the study characterized differences in genetic findings and clinical outcomes between ApHCM and non-apical HCM. These data help clarify the genetic basis and prognostic expectations of ApHCM to inform patient counseling and management.

Martel H, Lucas C, Benjelloun H et al. · European heart journal. Cardiovascular Imaging · (2026) · View on PubMed ↗

This ECG Does Not Fit: Rethinking Left Ventricular Hypertrophy.

This case report describes a 70-year-old man evaluated for progressive left ventricular hypertrophy (LVH) with atypical ECG findings in whom Anderson-Fabry disease (AFD) was suspected. The key finding was that cardiac MRI showed reduced native T1 values and genetic testing confirmed the GLA mutation p.N215S (late-onset AFD), despite confounding comorbidities such as hypertension, diabetes, chronic kidney disease, and prior PCI. The report highlights the diagnostic value of CMR tissue characterization and targeted genetic testing when ECG patterns for LVH are atypical.

Perini Schweiger C, Allocca G, Gugelmo G et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗

Midventricular Hypertrophic Cardiomyopathy With Apical Aneurysm Presenting as Persistent ST-Segment Elevation Mimicking Acute Myocardial Infarction.

This case studied a 62-year-old woman presenting with chest pain and persistent ST-segment elevation, ultimately diagnosed with midventricular hypertrophic cardiomyopathy (HCM) with systolic midcavity obstruction and a left ventricular apical aneurysm. Coronary angiography showed no obstructive coronary disease, while echocardiography and cardiac magnetic resonance confirmed the nonischemic structural cause of the ECG pattern. The report highlights that persistent ST-segment elevation can mimic acute myocardial infarction and that multimodality imaging is crucial to avoid misdiagnosis in HCM with apical aneurysm.

Kyvetos A, Liatakis I, Niarchou P et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗

---

Cardiac Imaging in Inflammatory/Immune-Mediated Heart Disease

Metabolic and redox pathway dysregulation in HIV-associated coronary endothelial dysfunction.

This prospective observational study examined virally suppressed people with HIV (PWH) to determine whether coronary endothelial dysfunction is linked to circulating serum proteomic signatures of metabolic and redox pathway dysregulation, using stress cardiovascular magnetic resonance (CMR) alongside high-throughput proteomics. The key finding was that specific proteomic patterns associated with metabolic/redox pathway dysregulation were present in PWH with coronary endothelial dysfunction despite sustained viral suppression. These results suggest that proteomic biomarkers reflecting metabolic and oxidative stress pathways may help explain persistent cardiovascular risk in treated HIV and could support mechanism-targeted risk stratification.

Keole KS, Bukhari S, Minhas AS et al. · American journal of physiology. Heart and circulatory physiology · (2026) · View on PubMed ↗

Imaging signatures of eosinophilic granulomatosis with polyangiitis-related myocarditis: A case report.

This radiology case report described a 23-year-old man with asthma, persistent hypereosinophilia, and multisystem involvement who was diagnosed with eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome) with suspected myocarditis. The key finding was that cardiac MRI identified myocarditis-related abnormalities consistent with eosinophilic infiltration, using late gadolinium enhancement and edema patterns to support the diagnosis. Clinically, it underscores cardiac MRI as the most sensitive noninvasive tool for detecting cardiac involvement in Churg-Strauss syndrome to enable timely adjustment of immunosuppressive therapy.

Lamassab NEH, Merimi I, Nabila I et al. · Radiology case reports · (2026) · View on PubMed ↗ · Free PDF ↗

Imaging insights into systemic tuberculosis with cardiac involvement: A rare challenging case of tuberculous chronic constrictive pericarditis and myocarditis.

This radiology case report described systemic tuberculosis with cardiac involvement, focusing on a rare presentation of tuberculous chronic constrictive pericarditis and myocarditis. The key finding was that multimodal advanced imaging was used to address diagnostic difficulty in cardiac TB when microbiological confirmation is often lacking. The case highlights the clinical value of multimodal imaging to improve diagnostic accuracy in challenging extrapulmonary tuberculosis with pericardial and myocardial disease.

Jabri M, Boulouiz S, Bazid Z et al. · Radiology case reports · (2026) · View on PubMed ↗ · Free PDF ↗

Cardiogenic shock after ocrelizumab infusion in relapsing-remitting multiple sclerosis.

This case report described a 42-year-old man with relapsing-remitting multiple sclerosis who developed severe, reversible left ventricular systolic dysfunction and cardiogenic shock after ocrelizumab infusion. Extensive evaluation—including coronary angiography, cardiac MRI, and endomyocardial biopsy—excluded ischemic and infectious causes, implicating ocrelizumab as a rare trigger of acute cardiac dysfunction. Clinically, it underscores the need for vigilance and prompt cardiac assessment in patients receiving ocrelizumab who develop symptoms of heart failure or shock.

De Napoli G, Gotti E, Baldovini C et al. · Multiple sclerosis (Houndmills, Basingstoke, England) · (2026) · View on PubMed ↗

Myopericarditis in Systemic Lupus Erythematosus Unmasking a Concomitant Diagnosis of Marfan Syndrome: A Case Report.

This case report describes acute myopericarditis in a patient with systemic lupus erythematosus (SLE) whose evaluation unmasked a concomitant diagnosis of Marfan syndrome. The key clinical finding was that significant systolic dysfunction from myopericarditis occurred in the setting of overlapping cardiovascular manifestations from SLE and an underlying hereditary connective tissue disorder (Marfan syndrome). Clinically, the report highlights the need to consider rare comorbid diagnoses when SLE patients present with severe cardiac inflammation and atypical or complicated cardiovascular findings.

Cabrera G, Neves G, Dias W et al. · Case reports in rheumatology · (2026) · View on PubMed ↗

Post-traumatic pericarditis following penetrating injury to the heart: a case report.

This case report studied a 22-year-old man who developed post-traumatic pericarditis progressing to transient constrictive pericarditis after a penetrating stab injury to both ventricles. Multimodal imaging was used for diagnosis and follow-up as inflammatory features emerged after the trauma. The significance is that post-cardiac injury syndrome can evolve into constrictive physiology even after penetrating injury, and multimodality imaging can guide timely recognition and management.

Ekhelikar S, Chukwudi I, Lewis G et al. · The international journal of cardiovascular imaging · (2026) · View on PubMed ↗

Inaugural complete heart block in anti-SSA negative systemic lupus erythematosus: the diagnostic role of anti-PM-Scl 100 antibodies.

This case report studied a 21-year-old woman with anti-SSA-negative systemic lupus erythematosus (SLE) who presented with inaugural complete heart block (CHB). Cardiac MRI and standard workup ruled out myocarditis, infiltrative disease, and common reversible causes, and the diagnostic emphasis was placed on anti-PM-Scl 100 antibodies (with mention of subtle “sentinel” signs). Clinically, it highlights that CHB can occur in anti-SSA-negative SLE and that anti-PM-Scl 100 antibodies may be important for diagnosis when typical anti-SSA/Ro antibodies are absent.

Dammene Debbih N, Laouar L, Dekdouk N et al. · Lupus · (2026) · View on PubMed ↗ · Free PDF ↗

Imaging Modalities Related to Cardiac Involvement in Systemic Sclerosis.

This article reviewed imaging modalities relevant to detecting cardiac involvement in systemic sclerosis (SSc), a disease characterized by microvasculopathy, autoimmunity, and fibrosis, with emphasis on clinical phenotypes such as diffuse versus limited cutaneous disease. The key finding was a synthesis of how different imaging techniques (e.g., echocardiography, cardiac magnetic resonance, and other modalities) contribute to identifying cardiac inflammation and fibrosis and to stratifying risk in SSc. Clinically, the review supports more targeted selection and interpretation of cardiac imaging to improve detection and management of SSc-related cardiac disease.

Markousis-Mavrogenis G, Sfikakis PP, Matucci-Cerinic M et al. · Journal of the American Heart Association · (2026) · 1 citations · View on PubMed ↗ · Free PDF ↗

---

Cardiac Imaging in Arrhythmias & Conduction Disorders

Cardiac Magnetic Resonance for the Prediction of Arrhythmic Events in Mitral Valve Prolapse: A Systematic Review and Meta-analysis.

This systematic review and meta-analysis assessed whether cardiac magnetic resonance (CMR) biomarkers—late gadolinium enhancement (LGE), mitral annular disjunction (MAD), and systolic curling—predict arrhythmic events in patients with mitral valve prolapse (MVP) across 15 studies totaling 1,994 patients. All three CMR biomarkers were significantly associated with higher arrhythmic risk, with pooled relative risks of 1.8 for LGE and 1.5 for MAD (and a similarly elevated association for systolic curling). These findings support using CMR-derived structural/functional markers to risk-stratify MVP patients for future arrhythmias.

Papanastasiou CA, Kampaktsis PN, Papalamprakopoulou Z et al. · The American journal of cardiology · (2026) · View on PubMed ↗

Interatrial block in hypertrophic cardiomyopathy: Associations with left atrial remodeling and adverse atrial outcomes.

The study examined interatrial block (IAB) in hypertrophic cardiomyopathy (HCM) and its links to left atrial (LA) remodeling and adverse atrial outcomes in 259 HCM patients without prior atrial fibrillation (AF) or stroke. IAB was defined by P-wave duration >120 ms, and cardiac magnetic resonance (CMR) was used to assess morphologic and functional LA parameters associated with IAB. By establishing prognostic value of IAB alongside CMR-defined LA remodeling, the work suggests a pathway for identifying HCM patients at higher risk for future atrial complications.

Anmad-Shihadeh LA, Teis A, Sabate M et al. · Heart rhythm · (2026) · 1 citations · View on PubMed ↗

Idiopathic 2:1 AV Block With Ventriculophasic Sinus Arrhythmia in a Young Male.

This case studied a 23-year-old man with influenza-like symptoms in whom an ECG incidentally revealed idiopathic 2:1 atrioventricular (AV) block with right bundle branch block and ventriculophasic sinus arrhythmia. After excluding structural and infiltrative disease, exercise stress testing further characterized the conduction abnormality. The clinical significance is that ventriculophasic sinus arrhythmia—typically linked to complete heart block—can also occur with isolated 2:1 AV block, expanding the differential for bradyarrhythmias in young adults.

Tortorici C, Duarte G, Mark JD et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗

Clinical Characteristics of Multifocal PVCs Originating from the Basal Septal Region of the Left Ventricle: Anatomy, mapping and ablation.

This study characterized multifocal premature ventricular complexes (PVCs) originating from the basal septal region of the left ventricle (LV) and proposed an anatomy-guided mapping and ablation strategy. In patients undergoing coronary venous mapping (CVM), ablation targeted the basal LV septum from the anterolateral LV ostium to the posterior LV process, aiming to address morphologically diverse but anatomically clustered PVCs. The clinical significance is a stepwise approach that can improve procedural efficiency and success when multifocal PVCs share a common septal origin.

Gardziejczyk P, Tertulien T, Stuckey M et al. · Heart rhythm · (2026) · View on PubMed ↗

---

Ischemic Heart Disease, MINOCA, and Post-MI Risk Stratification

Molecular mechanisms of coronary microembolization-induced MINOCA.

This basic research article examined the molecular mechanisms by which coronary microembolization (CME) can cause myocardial infarction with non-obstructive coronary arteries (MINOCA), a condition often diagnosed late because cardiac MRI is typically performed days after the index event. The key finding was that CME is a major underlying pathology in MINOCA, but its molecular pathways remain insufficiently defined, limiting rapid diagnostics and targeted therapy. Scientifically, clarifying CME’s molecular drivers could enable earlier MINOCA diagnosis and development of mechanism-based treatments.

Iske J, Thau H, Mesfin JM et al. · Basic research in cardiology · (2026) · View on PubMed ↗ · Free PDF ↗

Myocardial infarction with non-obstructive coronary arteries: A multimodal imaging approach to diagnosis and etiology-targeted therapy.

This review article addressed myocardial infarction with non-obstructive coronary arteries (MINOCA), a heterogeneous diagnosis accounting for about 5–15% of acute myocardial infarction presentations. It emphasized that accurate diagnosis requires systematically excluding non-ischemic mimics and identifying ischemic mechanisms, with intracoronary optical coherence tomography and intravascular ultrasound used to identify culprit coronary pathology and enable etiology-targeted therapy. A structured multimodal diagnostic approach is clinically significant because it can reduce therapeutic inertia and improve management for MINOCA patients.

Abdu FA · Current problems in cardiology · (2026) · 1 citations · View on PubMed ↗

Rethinking post-infarction remodelling: identification and validation of data-driven cardiac MRI phenotypes for risk stratification.

This prospective longitudinal study analyzed reperfused STEMI patients undergoing cardiac MRI at <7 days and at 6 months to identify data-driven left ventricular remodelling (ALVR) phenotypes for risk stratification. Using an unsupervised approach on longitudinal CMR measures, the authors derived and validated prognostic remodelling phenotypes in a derivation cohort (n=337) and an independent validation cohort (n=190), outperforming conventional ALVR definitions based on changes in LV end-diastolic volume index and ejection fraction. The findings support phenotype-based CMR risk stratification after STEMI, potentially enabling earlier and more accurate identification of patients at risk for adverse outcomes.

Xiang JY, Wu J, Zhao Y et al. · European heart journal. Cardiovascular Imaging · (2026) · View on PubMed ↗

Supporting transformer-based cardiac MRI segmentation with text-to-image controllable diffusion pipelines.

This study developed a transformer- and diffusion-model-based framework to support cardiac MRI segmentation using text-to-image controllable diffusion pipelines. The key finding is that combining LoRA (to generate pathology-aware label maps from textual prompts) with ControlNet (to enforce semantic and spatial conditioning) enables generation of anatomically consistent synthetic cardiac MRI scans with corresponding segmentation labels. Scientifically, this provides a method to create fully annotated synthetic datasets that can help train or validate cardiac MRI segmentation models when real labeled data are limited.

Fouadi H, Kas M, Ruichek Y et al. · Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society · (2026) · View on PubMed ↗

Prognostic Value of Scar Spatial Properties on CMR for Major Adverse Cardiovascular Events After Myocardial Infarction.

This retrospective study evaluated post-myocardial infarction patients in whom scar border zone channel features were quantified using ADAS 3D post-processing on cardiac MRI. The key finding was that spatial properties of the abnormal electrical conduction border zone channel (BZC), rather than conventional border zone characterization, improved prediction of major adverse cardiovascular events (including arrhythmic outcomes) after MI. These results support using CMR-derived scar spatial metrics to better stratify post-MI patients for future adverse events, potentially informing risk-guided management.

Zhao X, Wang L, Chen W et al. · Academic radiology · (2026) · View on PubMed ↗

---

Microvascular Dysfunction & Perfusion Metrics (CMR/PET/Angio-IMR/MVO)

Prognostic Implications of Coronary Microvascular Dysfunction in ST-Elevation Myocardial Infarction by Obesity Status.

In a multicenter prospective cohort of 497 ST-elevation myocardial infarction (STEMI) patients undergoing primary percutaneous coronary intervention (PPCI), this study examined whether coronary microvascular dysfunction (CMD) measured by the angiography-derived index of microcirculatory resistance (angio-IMR) predicts long-term cardiovascular outcomes across obesity categories. CMD was defined as angio-IMR > 40 U, and the abstract reports that CMD prevalence was comparable across BMI groups, while the detailed outcome associations were truncated. Clinically, linking angio-IMR-defined CMD with prognosis may support more tailored post-PPCI risk assessment in STEMI patients stratified by obesity.

Guo Q, Guo Y, Shi S et al. · Diabetes, obesity & metabolism · (2026) · View on PubMed ↗ · Free PDF ↗

Time-resolved aortic 3D shape reconstruction from a limited number of cine 2D MRI slices.

This study investigated a method to reconstruct time-resolved, subject-specific 3D aortic geometry from a limited number of standard cine 2D MRI slices by combining a statistical shape model with a differentiable volumetric mesh optimization algorithm. In synthetic testing and in vivo imaging of 30 subjects (19 volunteers and 11 aortic patients), the approach demonstrated feasibility and reconstruction accuracy using optimally positioned slices. The technique could reduce MRI acquisition burden while enabling patient-specific, time-resolved aortic assessment for research and potentially clinical planning.

Wolkerstorfer G, Buoso S, Schlenker R et al. · Computer methods and programs in biomedicine · (2026) · View on PubMed ↗ · Free PDF ↗

Prognostic impact of persistent microvascular obstruction on cardiac magnetic resonance after STEMI: A systematic review and meta-analysis.

This systematic review and meta-analysis evaluated prognostic differences between persistent versus transient (or absent) microvascular obstruction (MVO) on follow-up cardiac magnetic resonance (CMR) in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI). Across included cohort studies, the analysis compared outcomes based on MVO persistence status as determined by CMR follow-up imaging. Distinguishing persistent MVO from transient/no MVO is clinically significant because it may refine post-STEMI risk prediction and guide intensity of follow-up and therapy.

Gadelmawla AF, Taha AM, Alkuwaiti FA et al. · International journal of cardiology · (2026) · 1 citations · View on PubMed ↗ · Free PDF ↗

Angiography-Derived Index of Microcirculatory Resistance Predicts Microvascular Obstruction and Infarct Size in Patients With STEMI.

This study evaluated the angiography-derived index of microcirculatory resistance (AccuIMR) in 482 patients with ST-segment elevation myocardial infarction (STEMI) from a retrospective analysis of a prospective multicenter registry. AccuIMR was assessed against microvascular obstruction and infarct size measured by cardiac magnetic resonance (CMR), linking angiographic microvascular dysfunction to tissue-level injury. The significance is that AccuIMR may provide a practical, angiography-based predictor of microvascular obstruction and infarct size, potentially improving risk stratification after STEMI.

Sheng X, Hu Y, Zhang Y et al. · JACC. Asia · (2026) · View on PubMed ↗

---

Cardiac Imaging in Congenital/Structural Heart Disease (Fetal/Pediatric/Complex Anatomy)

Left ventricular diverticulum: A case report and differential diagnosis in an asymptomatic woman.

This case report described a 68-year-old asymptomatic woman with systemic hypertension in whom transthoracic echocardiography suggested an interventricular communication due to an apparent septal discontinuity and hypertrophic moderator band. The key finding was that cardiac MRI clarified the diagnosis as a left ventricular diverticulum, a congenital myocardial outpouching that can mimic other ventricular anomalies. The clinical significance is that CMR helps resolve important differential diagnoses for ventricular outpouchings, which can carry different prognoses and management implications.

Andrea D’Arma GM, Montatore M, Masino F et al. · Radiology case reports · (2026) · View on PubMed ↗ · Free PDF ↗

Atypical Atrial Flutter Unveiling Cor Triatriatum Sinister in a Stable Adult.

This case report studied a 64-year-old man with asymptomatic atrial flutter in whom transesophageal echocardiography (TEE) and cardiac magnetic resonance imaging (CMR) were used to identify cor triatriatum sinister (CTS). TEE excluded intracardiac thrombus and incidentally revealed a left atrial membrane, with CMR confirming nonobstructive CTS, enabling successful TEE-guided electrical cardioversion and anticoagulation. The report highlights that CTS can present with atrial arrhythmias in stable adults and that multimodality imaging can guide safe cardioversion.

Panjiyar B, Herrera AJ, Hermann J et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗

Topsy-Turvy Heart: Multimodality Prenatal and Postnatal Imaging for Clinical Management.

This case studied prenatal and postnatal imaging of a newborn diagnosed with “topsy-turvy heart” (axial rotation of the heart) and an aortopulmonary window, with suspected associated airway abnormalities. Using combined fetal echocardiography and fetal cardiac MRI, clinicians characterized complex intracardiac anatomy before birth, and the infant immediately developed severe respiratory failure requiring mechanical ventilation. The report underscores the clinical value of multimodality fetal imaging for anticipating extracardiac complications in rare congenital heart disease.

Meyer D, Geiger J, Weber R et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗

---

Cardiac Imaging Workflows & Protocol Optimization (Contrast-free, Free-breathing, Pediatric dosing)

A minimally invasive pre-operative measure of total pulmonary resistance is associated with early adverse outcomes following total cavopulmonary connection.

This European Heart Journal Imaging Methods and Practice study developed a minimally invasive pre-operative estimate of total pulmonary resistance (TPR) at the bidirectional cavopulmonary connection (BCPC) stage using jugular venous pressure as a surrogate for central venous pressure (CVP). The key finding (not fully shown due to truncation) is that higher TPR is associated with early adverse outcomes after total cavopulmonary connection (TCPC), including early Fontan failure and/or prolonged post-operative ICU stay. Scientifically and clinically, this could enable earlier identification of high-risk patients for TCPC and guide perioperative management strategies.

Nadarajan N, Muthurangu V, Quail MA · European heart journal. Imaging methods and practice · (2026) · View on PubMed ↗ · Free PDF ↗

Right ventricular longitudinal function is associated with exercise capacity in pre-capillary pulmonary hypertension: a multimodality imaging study.

This multimodality imaging study evaluated associations between right ventricular (RV) longitudinal function and exercise capacity in 49 patients with pre-capillary pulmonary hypertension (PHprecap). Patients underwent 6-minute walk distance (6MWD), NT-proBNP sampling, right heart catheterization, and RV assessment by echocardiography and cardiac magnetic resonance imaging (CMR) within 24 hours, and the abstract indicates RV longitudinal dysfunction is linked to exercise capacity (with reported impaired RV function rates by CMR and echo). If confirmed in the full analysis, RV longitudinal metrics from echo/CMR could improve functional risk prediction in PHprecap beyond traditional risk strata.

Jumatate R, Labaf A, Ingvarsson A et al. · European heart journal. Imaging methods and practice · (2026) · View on PubMed ↗ · Free PDF ↗

Determinants of Abnormal Pulmonary Vasodilatory Response With Exercise in HFpEF: Pulmonary Vascular-Left Atrial Axis Abnormalities.

This two-step invasive cardiopulmonary exercise testing study investigated determinants of abnormal pulmonary vasodilatory response with exercise in 164 participants, including 80 HFpEF patients, 57 with pre-capillary PH, and 27 with non-cardiac dyspnea. An unfavorable exercise PVR response was defined as exercise PVR >1.74 Woods units with <22% ∆PVR decrease during exercise, and the study then identifies high-risk correlates specifically for HFpEF within this framework, but the provided abstract is truncated before listing the correlates. Clinically, defining HFpEF-specific pulmonary vascular-left atrial axis abnormalities could help target therapies to prevent exercise-induced right ventricular failure.

Garcia-Arango M, Kristo A, El Shaer A et al. · Comprehensive Physiology · (2026) · View on PubMed ↗ · Free PDF ↗

Right ventricular remodeling and circulating metabolic profiles of patients with chronic thromboembolic pulmonary hypertension before and after pulmonary endarterectomy.

This prospective study characterized right ventricular (RV) remodeling and circulating metabolic profiles in 10 patients with chronic thromboembolic pulmonary hypertension (CTEPH) before and after pulmonary endarterectomy (PEA), compared with 10 controls with normal RV function undergoing aortic surgery. Using longitudinal RV imaging and histology alongside metabolomic profiling (18F labeling mentioned in the truncated methods), the key finding is expected to describe how RV structure/function and circulating metabolites change after PEA, but the abstract text provided does not include the results. If the full report identifies metabolite patterns linked to RV reverse remodeling, these biomarkers could guide future mechanistic studies and therapeutic development in CTEPH.

Guimaron S, Mercier J, Hautbergue T et al. · JHLT open · (2026) · View on PubMed ↗ · Free PDF ↗

Reduced regadenoson dose using heart rate-targeted titration in paediatric stress perfusion CMR.

This retrospective pediatric CMR study assessed feasibility, safety, and diagnostic performance of heart rate–targeted incremental regadenoson titration (aiming for ≥20% heart-rate increase) versus fixed weight-based dosing in 31 consecutive children undergoing stress perfusion CMR for known or suspected coronary artery disease. The key finding was that HR-targeted titration was technically successful in most studies and enabled individualized coronary vasodilation while potentially reducing excessive regadenoson exposure. This approach may improve tolerability and optimize diagnostic quality in pediatric stress perfusion CMR by tailoring adenosine-receptor agonist dosing to physiologic response.

Quail MA, Tann O, Linton R et al. · European heart journal. Imaging methods and practice · (2026) · View on PubMed ↗ · Free PDF ↗

Estimating the Sodium Content: A Case Series of Benign and Malignant Renal Tumours Using 23Na-MRI at 3 T.

This prospective case series applied 3T 23Na-MRI to estimate sodium content in localized renal tumors from 10 patients, including renal oncocytoma and chromophobe and clear cell renal cell carcinoma subtypes. The key finding was the feasibility of using sodium MRI–derived sodium content estimates to characterize and potentially differentiate benign versus malignant renal tumors. Scientifically and clinically, quantifying tumor sodium non-invasively could improve early subtyping of indeterminate renal masses and guide management decisions.

Horvat-Menih I, Birchall JR, Zamora-Morales MJ et al. · NMR in biomedicine · (2026) · View on PubMed ↗ · Free PDF ↗

Comparison of Left Ventricular Ejection Fraction and Disease Classification by Cardiac Magnetic Resonance and Echocardiography.

This retrospective study compared left ventricular ejection fraction (LVEF) measured by cardiac magnetic resonance (CMR) versus transthoracic echocardiography (TTE) and evaluated determinants of discordance in patients imaged within 1 week. The key finding details were truncated in the abstract, but the study specifically assessed how modality differences affect clinical classification using European Society of Cardiology heart failure thresholds (50% and 35%). The results are intended to inform which imaging modality more reliably supports guideline-based LVEF-driven clinical decisions.

Le Y, An J, Liang L et al. · The American journal of cardiology · (2026) · View on PubMed ↗

Aorta and coronary artery assessment using high-contrast respiratory motion corrected and ECG-gated 3D T2-prepared GRE MRI with Dixon fat-water separation in patients with and without prior aortic root surgery at 3 T.

This prospective study evaluated a novel non-contrast, ECG-gated, respiratory motion-corrected 3T cardiovascular MRI sequence—T2-prepared GRE with Dixon fat-water separation (T2p GD)—for assessing the aorta and coronary arteries in 55 patients with and without prior aortic root surgery. The key finding was that the sequence was validated against standard contrast-enhanced MR angiography (CE-MRA), with diagnostic performance and signal-to-noise ratio reported in the full study but truncated in the abstract text. If broadly reproducible, T2p GD could enable accurate aortic/coronary assessment without contrast in patients where gadolinium is undesirable.

Cereghetti GM, Huber LP, Todorski I et al. · European journal of radiology · (2026) · View on PubMed ↗

Vascular compliance phenotyping in pulmonary arterial hypertension (a PVDOMICS study).

Using adult participants from the PVDOMICS cohort (World Symposium Group 1 pulmonary arterial hypertension), this study derived pulmonary vascular compliance from right heart catheterization measurements and examined associations with cardiac morphology, exercise metrics, and mortality. The abstract indicates the goal was to identify phenotypic factors linked to compliance and evaluate its prognostic relationships, but the specific results were truncated. If compliance proves prognostically robust, it could become a clinically actionable hemodynamic biomarker for risk stratification in pulmonary arterial hypertension.

Wilson TG, Oppegard L, Pi H et al. · JHLT open · (2026) · View on PubMed ↗ · Free PDF ↗

Automation Software for Transesophageal Echocardiography in Cardiac Patients: A Scoping Review.

This scoping review mapped evidence on automation software for transesophageal echocardiography (TEE) in cardiac patients, comparing automated measurements with manual techniques and summarizing validation outcomes. It aimed to identify how well current tools perform, where they have been validated, and what evidence gaps remain given heterogeneity across software and workflows. Clarifying the state of automated TEE is scientifically and clinically important for improving efficiency and reproducibility in peri-procedural cardiac imaging.

Ghijselings I, Elst J, Rex S et al. · Journal of cardiothoracic and vascular anesthesia · (2026) · View on PubMed ↗

Free-Breathing 3D Whole Heart and Aorta Cine MRI Without Contrast Agent-Comparison to Clinical Standard.

This prospective study evaluated a free-breathing 3D whole-heart and aorta cine MRI protocol without a contrast agent at 1.5 T, designed to simultaneously assess cardiac function and aortic anatomy in a single acquisition. Tested in 24 healthy volunteers (mean age ~31.8 years, 50% female), the technique was compared against a clinical standard protocol requiring conventional breath-hold acquisitions. A contrast-free, free-breathing approach could improve patient tolerance and streamline cardiac MRI workflows while preserving diagnostic capability.

Chen R, Lu H, Cernicanu A et al. · Journal of magnetic resonance imaging : JMRI · (2026) · View on PubMed ↗ · Free PDF ↗

Poor R-wave progression fails to detect anterior myocardial fibrosis in MESA.

The study evaluated whether poor R-wave progression (PRWP) on 12-lead ECG identifies anterior myocardial fibrosis on cardiac magnetic resonance (CMR) in Multi-Ethnic Study of Atherosclerosis (MESA) Examination 5 participants. PRWP—defined as RV3 ≤3 mm with RV3 > RV2 (and tested against a Zema MI sensitivity criterion)—showed poor sensitivity for detecting the strict CMR reference of ischemic/transmural scar with ≥2 left anterior descending (LAD) segments or LV scar burden ≥5%. These findings indicate that PRWP is not a reliable surrogate for anterior-wall fibrosis on modern CMR, limiting its clinical use for risk stratification of subclinical myocardial injury.

de Alencar JN, Morales PAS · International journal of cardiology · (2026) · View on PubMed ↗

Reference intervals for myocardial T1, T2, and extracellular volume in clinically normal dogs and cats at 3-Tesla magnetic resonance imaging: a single-center study.

This single-center study established reference intervals for myocardial native T1, native T2, and extracellular volume fraction (ECV) in clinically normal dogs and cats using 3-T cardiac MRI with ECG gating under general anesthesia. The authors generated species-specific mapping-based reference ranges using midventricular short-axis native T1/T2 mapping sequences adapted from human protocols and derived ECV from native values. These reference intervals support more accurate interpretation of cardiac MRI tissue characterization in veterinary cardiology and research.

Fries RC, Kadotani S, Toborowsky C et al. · American journal of veterinary research · (2026) · View on PubMed ↗

Indications, protocols, and interpretation of cardiovascular imaging for the evaluation and management of athletes. A Clinical Consensus Statement of the European Association of Preventive Cardiology (EAPC) and the European Association of Cardiovascular Imaging (EACVI) of the European Society of Cardiology (ESC). Part 2-Cardiovascular Magnetic Resonance, Cardiac CT and Nuclear Imaging.

This European Society of Cardiology (ESC) clinical consensus statement studied how to use cardiovascular imaging modalities to evaluate and manage athletes, focusing on cardiovascular magnetic resonance (CMR), cardiac CT, and nuclear imaging. It provides multimodality guidance on indications, protocols, and interpretation to distinguish physiological athlete remodeling from pathological substrates associated with exercise-related adverse events. The consensus is clinically significant because it standardizes advanced imaging workflows for risk stratification in sports cardiology.

Maestrini V, Gati S, D’Ascenzi F et al. · European heart journal. Cardiovascular Imaging · (2026) · 2 citations · View on PubMed ↗

Indications, protocols, and interpretation of cardiovascular imaging for the evaluation and management of athletes: a clinical consensus statement of the European Association of Preventive Cardiology (EAPC) and the European Association of Cardiovascular Imaging (EACVI) of the ESC: Part 1-Exercise imaging.

This ESC/EAPC-EACVI consensus statement studied exercise imaging in athletes, emphasizing exercise stress echocardiography (ESE) as a key noninvasive tool. It synthesizes evidence and offers practical recommendations for indications, protocols, and interpretation to assess cardiac reserve, unmask concealed cardiomyopathies, and stratify risk in competitive and recreational athletes. The guidance is significant for harmonizing exercise-imaging practice to improve detection of pathology masked by resting physiological adaptation.

D’Ascenzi F, Sanz-de la Garza M, Maestrini V et al. · European heart journal. Cardiovascular Imaging · (2026) · View on PubMed ↗ · Free PDF ↗

Impact of age, heart rate, and body surface area on myocardial native T1, T2, and extracellular volume fraction in pediatric patients at 1.5 Tesla cardiac magnetic resonance imaging.

This pediatric reference-values study assessed how age, heart rate, and body surface area affect myocardial native T1, T2, and extracellular volume fraction measured by 1.5 Tesla cardiac MRI. The key finding was that these physiological variables meaningfully influence global LV parametric mapping values (native T1, T2, and ECV), motivating population-specific reference ranges for children. The results improve interpretability of CMR tissue mapping in pediatrics and support more accurate assessment of diffuse fibrosis (native T1/ECV) and edema (T2) in clinical practice.

Riaza-Martin L, Escudero-Fernandez JM, Riera-Soler L et al. · Pediatric radiology · (2026) · View on PubMed ↗ · Free PDF ↗

SPACE: Pathophysiology of Platypnea-Orthodeoxia Syndrome With Aortic Aneurysm in 5 Steps.

This JACC Case Reports article presents a 47-year-old woman with platypnea-orthodeoxia syndrome in the setting of an ascending aortic aneurysm and bicuspid aortic valve. The key finding was that multimodal imaging showed persistent right-to-left shunting across a patent foramen ovale despite normal pulmonary vascular resistance, driven by aneurysm-related cardiac axis displacement and mechanical compression of the interatrial septum/right atrium plus a prominent Eustachian valve. The case underscores that anatomical and flow-redirecting mechanisms can cause positional hypoxemia, and that surgical correction of the aneurysm with PFO closure can be curative.

Hanses U, Osteresch R, Rühle S et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗

---

Multimodality Imaging for Diagnostic Differentials (PET/CT, CMR, Echo, Nuclear)

Quantitative 99mTc-PYP SPECT/CT at 90 minutes improves diagnostic stratification in transthyretin cardiac amyloidosis.

This retrospective single-center study evaluated 170 patients with suspected cardiac amyloidosis to test whether quantitative 99mTc-PYP SPECT/CT at 90 minutes post-injection improves diagnostic stratification beyond standard planar imaging at 60 and 180 minutes. The key finding was that adding quantitative SPECT/CT at 90 minutes increased diagnostic specificity, particularly improving classification in patients with low planar uptake (e.g., Perugini score 1). Scientifically and clinically, the results support an optimized imaging protocol to better distinguish transthyretin cardiac amyloidosis from mimics and reduce indeterminate planar scans.

Nazerani-Zemann T, Stanzel S, Weitzer F et al. · European journal of nuclear medicine and molecular imaging · (2026) · View on PubMed ↗ · Free PDF ↗

18F-fluorodeoxyglucose positron emission tomography and rest myocardial perfusion imaging in non-granulomatous myocarditis.

This multicenter prospective observational feasibility study evaluated combined 18F-fluorodeoxyglucose (FDG) PET/CT and rest myocardial perfusion imaging (rMPI) in patients with suspected non-granulomatous myocarditis, with endomyocardial biopsy (EMB) or adjudicated clinical diagnosis as the reference standard. The key diagnostic performance results were not fully available in the provided abstract text. If validated, combining FDG-PET/CT with rMPI could improve noninvasive diagnosis and characterization of non-granulomatous myocarditis.

Lucinian YA, Martineau P, Harel F et al. · European journal of nuclear medicine and molecular imaging · (2026) · View on PubMed ↗

Bridging Diagnostic Gaps in AL Cardiac Amyloidosis: The Emerging Role of 68 Ga-FAPI PET/CT.

The report described a 56-year-old man with suspected AL cardiac amyloidosis whose conventional workup (cardiac MRI, bone marrow biopsy, endomyocardial biopsy, and equivocal 99mTc-pyrophosphate scintigraphy) was inconclusive. 68Ga-FAPI-46 PET/CT showed intense myocardial uptake, prompting repeat bone marrow biopsy that confirmed AL amyloidosis. This case highlights the emerging role of 68Ga-FAPI PET/CT as a bridging diagnostic tool when biopsy and standard imaging are discordant or non-diagnostic.

Kumar SA, Goyal H, Ahmed AS et al. · Clinical nuclear medicine · (2026) · View on PubMed ↗ · Free PDF ↗

Wild-Type Transthyretin Amyloid Cardiomyopathy With Positive 18F-FDG/13N-Ammonia Cardiac Positron Emission Tomography.

This case report studied an 85-year-old man with wild-type transthyretin amyloid cardiomyopathy (wtATTR-CM) whose diagnosis was initially confounded by imaging that mimicked cardiac sarcoidosis. 18F-FDG/13N-ammonia PET/CT showed matching perfusion defects with focal FDG uptake, and despite methotrexate he developed progressive heart failure with worsening echocardiographic findings including increasing LV wall thickness and impaired global longitudinal strain. The case emphasizes that atypical PET/CT patterns can delay wtATTR-CM diagnosis and supports careful differential diagnosis when imaging suggests inflammatory cardiomyopathy.

Elalfy A, Kholeif Z, Rashwan R et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗

---

Therapeutic Trials & Real-World Treatment Studies (Cardiac/Immune/Dystrophin/DMD/SGLT2i)

Use of SGLT2 Inhibitors in Dystrophin Deficient Cardiomyopathy: A Multi-center Study Using the ACTION Registry.

This multi-center ACTION dystrophinopathy registry study evaluated use of sodium-glucose cotransporter-2 inhibitors (SGLT2i) in 80 patients with dystrophin-deficient cardiomyopathy (Duchenne muscular dystrophy). The study reports initiation of SGLT2i (median age 19.6 years) and aims to characterize indications, effects on cardiac function, and adverse effects, but the provided abstract text is truncated before the key results are stated. If confirmed in the full report, these real-world data could support evidence-based SGLT2i use for cardiomyopathy in dystrophin-deficient patients where published guidance is currently lacking.

Harris RE, Wittlieb-Weber CA, Villa C et al. · Pediatric cardiology · (2026) · View on PubMed ↗

Aspirin therapy after heart transplantation is associated with higher myocardial perfusion reserve assessed by cardiovascular magnetic resonance imaging.

This multicenter observational study in heart-transplant recipients in Sweden assessed whether aspirin therapy is associated with myocardial perfusion reserve (MPR) as a noninvasive marker of cardiac allograft vasculopathy (CAV) using cardiovascular magnetic resonance (CMR) and coronary angiography. The key finding was that patients receiving aspirin after heart transplantation had higher myocardial perfusion reserve compared with those not on aspirin. This suggests aspirin may be linked to reduced CAV-related perfusion impairment, supporting its potential role in long-term allograft vascular protection.

Jablonowski R, Löfman IH, Andersson HB et al. · JHLT open · (2026) · View on PubMed ↗ · Free PDF ↗

Management of Iron Overload in Infants and Toddlers With Diamond-Blackfan Anemia Syndrome: A French-Italian Study.

This retrospective multicenter French-Italian study evaluated iron chelation timing and indications in 167 transfused infants and toddlers with Diamond-Blackfan anemia syndrome (DBAS) from national registries. Thirty-eight percent (64/167) initiated chelation before age 3 years, with typical triggers of serum ferritin ≥500 ng/mL (median 1340 ng/mL) and >10 transfusions, and most received deferasirox. Early chelation in very young DBAS patients appears feasible and is clinically important to prevent early, potentially severe transfusional iron overload.

Torchio F, Lecalvez B, Garelli E et al. · American journal of hematology · (2026) · View on PubMed ↗ · Free PDF ↗

Losartan and prednisolone for post-COVID syndrome and cardiac inflammation: a randomized, double-blind, placebo-controlled trial.

In the Myoflame-19 randomized, double-blind, placebo-controlled trial, 279 participants with post-COVID syndrome and inflammatory cardiac involvement on cardiovascular magnetic resonance were randomized to losartan plus prednisolone versus matching placebos for 16 weeks. The primary endpoint—change in left ventricular ejection fraction—was neutral, with no meaningful between-group difference (modified intention-to-treat: n=124 vs n=122). The trial’s results suggest that targeting immune/endothelial dysfunction and low-grade inflammation with losartan and prednisolone does not improve LV systolic function in this CMR-defined post-COVID inflammatory phenotype.

Puntmann VO, Nagel E, Beitzke D et al. · Nature communications · (2026) · View on PubMed ↗ · Free PDF ↗

Deramiocel heart-derived cellular therapy in advanced Duchenne muscular dystrophy (HOPE-3): a phase 3, randomised, double-blind, placebo-controlled trial.

This phase 3, multicenter, randomized, double-blind, placebo-controlled trial studied deramiocel (human allogeneic cardiosphere-derived cells) in participants aged ≥10 years with advanced Duchenne muscular dystrophy (DMD). Deramiocel was evaluated for efficacy and safety to support prior HOPE-2 findings, using an intravenous infusion approach (details truncated in the abstract). Scientifically, the trial tests whether a heart-derived cellular therapy can improve outcomes in advanced DMD beyond earlier phase studies, with potential implications for treating both skeletal and cardiac muscle decline.

McDonald CM, Villa C, Soslow JH et al. · Lancet (London, England) · (2026) · View on PubMed ↗ · Free PDF ↗

---

Non-cardiac Oncology/Imaging Biomarkers (PET/CT, Lymphoma, Melanoma, NSCLC)

The Prognostic Role of Interim [18F]FDG PET/CT in Diffuse Large B-Cell Lymphoma: An Updated Systematic Review and Meta-analysis.

This updated systematic review and meta-analysis evaluated whether interim 18F-FDG PET/CT (iPET/CT) predicts progression-free survival (PFS) in patients with diffuse large B-cell lymphoma (DLBCL), pooling complete metabolic response rates and hazard ratios from studies published through December 31, 2025. The key finding was the pooled prognostic performance of iPET/CT for PFS using a random-effects model, addressing prior inconsistencies related to scan timing and interpretation. Clinically, iPET/CT could support earlier treatment risk-adaptation in DLBCL if its prognostic accuracy is sufficiently robust across included cohorts.

Albano D, Chauvie S, Rizzo A et al. · Clinical lymphoma, myeloma & leukemia · (2026) · View on PubMed ↗ · Free PDF ↗

Beyond target lesions: Prognostic value of longitudinal AI-derived whole-body [1⁸F]FDG PET/CT metrics in metastatic melanoma.

This study assessed whether an AI-based semi-automated tool for longitudinal whole-body [18F]FDG PET/CT quantification of total metabolic tumor volume (TMTV) and total lesion glycolysis (TLG) predicts outcomes in 43 patients with unresectable metastatic melanoma treated with immune checkpoint inhibitors (ICIs). The abstract indicates the investigators compared AI-derived longitudinal PET metrics with established metabolic response criteria, but the specific prognostic effect sizes were truncated. If confirmed, AI-derived longitudinal TMTV/TLG could refine risk stratification beyond conventional “target lesion” response in ICI-treated metastatic melanoma.

Sachpekidis C, Vagenas TP, Müller M et al. · European journal of nuclear medicine and molecular imaging · (2026) · 1 citations · View on PubMed ↗ · Free PDF ↗

Compatibility of different PET/CT criteria in evaluating treatment response and survival in non-small cell lung cancer patients treated with immunotherapy.

The study evaluated how different 18F-FDG PET/CT response criteria (PERCIST, PECRIT, PERCIMT, and imPERCIST5) agree and how they relate to overall survival (OS) in 35 metastatic non-small cell lung cancer (NSCLC) patients receiving second-line or later immunotherapy. Treatment response categories (complete metabolic response, partial metabolic response, stable metabolic disease, progressive metabolic disease) were assigned based on each criterion using pre-treatment and first post-treatment PET/CT scans. The findings clarify which PET/CT metric best tracks survival in immunotherapy-treated NSCLC, supporting more consistent response assessment in clinical practice.

Eroğlu İ, Aydos U, Ateş YÜ et al. · Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · (2026) · View on PubMed ↗

---

Cardiovascular Epidemiology & Public Health/Policy (including non-imaging reviews)

Trends in heart failure-related mortality among breast cancer patients in the United States from 1999 to 2024.

This retrospective CDC WONDER database analysis (1999–2024) quantified trends in heart failure–related mortality among women with breast cancer aged ≥25 years, stratifying by race/ethnicity and geographic region. The key finding was the temporal pattern of HF-related mortality rates in this population over the 25-year period. These trend data are clinically significant for identifying high-burden subgroups and informing surveillance and cardio-oncology prevention strategies.

Jaiswal V, Kumar D, Kalra K et al. · American journal of preventive cardiology · (2026) · View on PubMed ↗ · Free PDF ↗

Lymphatic endothelial cells actively shape immune responses in the lungs.

This narrative review summarized experimental evidence on how pulmonary lymphatic endothelial cells actively shape immune responses in the lungs, including mechanisms such as PAR1-mediated permeabilization of lymphatic junctions. The key finding is that lung lymphatic endothelial cells are not passive conduits but actively regulate acute inflammation, adaptive immunity, and tissue remodeling in organ-specific ways. Scientifically, the review highlights lymphatic endothelial signaling pathways (e.g., PAR1) as potential targets for controlling inflammatory lung diseases and their long-term remodeling.

Rivers AK, Migues Ramirez C, Cleary SJ · Current opinion in immunology · (2026) · View on PubMed ↗ · Free PDF ↗

The intersection of infectious diseases and cardiovascular disease in Africa: A narrative review.

This narrative review examined the intersection of infectious diseases and cardiovascular disease in sub-Saharan Africa (SSA), focusing on how neglected tropical diseases and latent parasitic infections—especially in people with HIV/AIDS—can affect the heart. The key finding was that infectious and immunosuppression-related reactivation in SSA, compounded by environmental and healthcare constraints, contributes to cardiovascular complications through diverse etiologies and clinical presentations. The significance is that it frames region-specific infectious risk as a driver of cardiovascular morbidity, supporting integrated prevention and diagnostic strategies in SSA populations.

Ogah OS, Umuerri EM, Hahnle J et al. · Journal of the National Medical Association · (2026) · View on PubMed ↗

Mortality among people who had contact with the criminal justice system during adolescence: a systematic review and meta-analysis.

This systematic review and meta-analysis synthesized cohort evidence on mortality among people who had contact with the criminal justice system during adolescence (before age 20). The key finding was that such youth have increased risk of death compared with the general population, and the review extracted causes of death including non-communicable disease, communicable disease, injury, substance-related causes, suicide, and homicide. Scientifically, the synthesis clarifies the magnitude and drivers of excess mortality in this high-risk population and can inform targeted public health and policy interventions.

Martinez A, Janca E, Willoughby M et al. · Social science & medicine (1982) · (2026) · 1 citations · View on PubMed ↗ · Free PDF ↗

Cardiovascular Complications in Hemoglobinopathies: Pathophysiology, Clinical Spectrum, and Management.

This narrative review summarized cardiovascular complications in hemoglobinopathies, focusing on sickle cell disease and thalassemia syndromes and their pathophysiology, clinical spectrum, and management. It highlights that improved survival from transfusion practices, iron chelation, and disease-modifying therapies has revealed a broad range of cardiac and vascular manifestations including cardiomyopathy, heart failure, pulmonary hypertension, arrhythmias, microvascular ischemia, and valvular dysfunction. Understanding these mechanisms and phenotypes is important for developing targeted cardiovascular screening and management strategies in patients with hemoglobinopathies.

Bradach D, Salavarria KC, Diaz-Arribasplata S et al. · European journal of haematology · (2026) · View on PubMed ↗

Safety and efficacy of intravenous thrombolytics among patients with emergent intracranial stenting after thrombectomy: Subanalysis of the RESISTANT registry.

The subanalysis of the RESISTANT registry studied safety and efficacy of intravenous thrombolysis (IVT) in acute ischemic stroke patients who underwent endovascular therapy (EVT) with emergent intracranial stenting for intracranial atherosclerotic disease (ICAD)-large vessel occlusion (LVO). Among consecutive patients across 36 centers in 7 countries, the primary endpoint was the 90-day modified Rankin Scale (mRS) ordinal shift, with secondary outcomes including excellent functional outcome (mRS 0–1). The results inform whether adding IVT before EVT with adjuvant stenting improves outcomes without increasing harm in this specific high-risk stroke subgroup.

Mujanovic A, Olivé-Gadea M, Diana F et al. · International journal of stroke : official journal of the International Stroke Society · (2026) · View on PubMed ↗ · Free PDF ↗

Procedural and Therapy Peripheral Intravenous Catheters: A Framework for Safety, Quality and Patient-Centred Care.

This narrative review developed a conceptual framework for peripheral intravenous catheters that differentiates devices by dwell time and therapeutic purpose to improve safety, quality, and patient-centered care. It synthesized evidence from clinical guidelines, expert consensus, and a PubMed search (through November 25, 2024) using SANRA quality criteria for narrative reviews. The framework is intended to guide standardized catheter selection and reduce device-related complications across clinical settings.

Drugeon B, Rickard CM, Peters N et al. · Journal of advanced nursing · (2026) · 1 citations · View on PubMed ↗ · Free PDF ↗

Strategies for resilient climate in smart cities mediated by Nash equilibrium and autonomous decision-makers.

This study developed a decision-making framework for resilient climate in smart cities by integrating Nash equilibrium, autonomous multi-agent systems, and machine learning. It modeled each city as an autonomous agent that selects pollution and climate-warming risk management policies to mitigate global warming effects under uncertainty. The approach is significant for translating game-theoretic and AI-based strategies into actionable, city-specific climate policy planning.

Latha CM, Alvarado-Mentado M · Journal of environmental management · (2026) · View on PubMed ↗

Integrating Multimodal Data and Genomics for a Comprehensive Assessment of Cardiovascular Aging and Its Impact.

Using UK Biobank data, this study integrated multimodal cardiovascular imaging/physiology biomarkers (including CMR) with genomics to quantify cardiovascular aging and test its genetic architecture and prognostic relevance. The key finding was that machine-learning models combining CMR, ECG, arterial stiffness, and carotid ultrasound biomarkers produced a cardiovascular aging measure with measurable genetic determinants and prognostic associations. Scientifically, it advances a comprehensive, data-driven framework linking cardiovascular aging phenotypes to genetic risk and outcomes.

Abula A, Yuan Y, Li X et al. · Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · (2026) · View on PubMed ↗ · Free PDF ↗

Evolving paradigms in lymph node surgery in endometrial cancer: insights from the multicenter E-PEC trial.

This multicenter retrospective cohort study analyzed temporal trends in lymph node surgery and staging for endometrial cancer in selected German academic centers between 2018 and 2022 as part of the E-PEC trial project. Patients undergoing primary surgical treatment for newly diagnosed endometrial cancer were included, while those receiving primary systemic or chemoradiation therapy were excluded, and staging approaches were stratified by year of surgery. The significance is that it documents evolving surgical paradigms in lymph node management, informing how practice patterns change over time in real-world endometrial cancer care.

Eser B, Papior D, Salmanton-García J et al. · Archives of gynecology and obstetrics · (2026) · View on PubMed ↗ · Free PDF ↗

---

---

Generated automatically on August 02, 2026. Covers PubMed articles published July 26, 2026 – August 02, 2026. Summaries are AI-generated; always consult the original publication for clinical or research decisions.