What's New in Cardiac MRI? — August 14, 2026
AI-summarised digest of 60 PubMed articles on Cardiac MRI published in the last 7 days.
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What’s New in Cardiac MRI?
August 14, 2026 · 60 articles · 15 research themes · covering August 07, 2026 – August 14, 2026
Overview
Across this week’s set of studies, a dominant theme is the expanding role of cardiovascular magnetic resonance (CMR) and other advanced imaging modalities for both diagnosis and risk stratification. Multiple papers focus on improving the reliability and interpretability of CMR-derived biomarkers—ranging from sequence- and population-specific myocardial T1 reference values, to CMR-based assessment of remodeling after interventions (e.g., TIPS, AVR), and to mechanistic tissue characterization in conditions such as radiation injury, noncompaction cardiomyopathy, and persistent plaque hemorrhage despite statin therapy. Several works also push the technical frontier of quantitative imaging (e.g., transmural deformation from 3D echo, automated VENC selection for flow MRI, and automated LV stiffness segmentation from cardiac MRE), aiming to reduce operator dependence and improve reproducibility.
A second major thread is precision phenotyping of cardiovascular disease using mechanistic frameworks and genotype- or pathway-informed risk. In heart failure, studies and reviews emphasize HFpEF heterogeneity through axes such as left atrial (LA) myopathy and coronary microvascular dysfunction, including multimodal imaging-resolved phenotyping in animal models. In arrhythmia and cardiomyopathy, exercise-induced ventricular arrhythmias, unstable VT mapping strategies, and nuanced genotype–phenotype relationships (e.g., compound MYH7 variants, latent instability in arrhythmogenic cardiomyopathy) highlight how “hidden” risk can be unmasked beyond resting clinical features. Complementing this, guideline and pathway papers (e.g., HFrEF guideline appraisal, myocarditis diagnostic pathways, tricuspid regurgitation work-up algorithms) underscore the push toward standardized, evidence-based decision-making.
Finally, the digest reflects a broader translational push linking biomarkers, AI, and targeted therapies to clinical monitoring. AI-focused reviews and studies show how deep learning is moving toward scalable, automated interpretation of imaging-derived phenotypes (including muscle-aware sarcopenic obesity risk). In parallel, oncology and systemic disease research appears in the cardiovascular-adjacent space: PET/CT metabolic response standardization in ICI-treated melanoma, mechanistic KRASG12V degradation strategies, and microbiome-linked cardiometabolic risk (imidazole propionate). Together, these articles suggest a field converging on more quantitative, standardized, and mechanistically grounded approaches—supported by automation and improved imaging—to refine prognosis and guide therapy.
Cardiac MRI (CMR) Biomarkers & Tissue Characterization
Native myocardial T1 reference values in a tunisian cohort using MOLLI and SMART1Map : List of Authors.
This study established native myocardial T1 reference ranges in a Tunisian cohort of 94 healthy volunteers using cardiac MRI sequences MOLLI 5(3)3 and SMART1Map, and assessed sex- and age-related differences as well as inter-site variability of MOLLI across two centers. The key result was that native T1 reference values differed by demographic factors and that MOLLI measurements showed measurable inter-site variability even with identical scanners and protocols. Population- and sequence-specific T1 reference standards improve diagnostic accuracy for myocardial tissue characterization in clinical practice.
Dali M, Benameur N, Deriche M et al. · Scientific reports · (2026) · View on PubMed ↗
Cardiovascular magnetic resonance reveals stable myocardial tissue characteristics despite cardiac remodelling after transjugular intrahepatic portosystemic shunt in liver cirrhosis.
This prospective CMR study assessed myocardial function, remodeling, and tissue characteristics before and after transjugular intrahepatic portosystemic shunt (TIPS) in patients with liver cirrhosis. Despite cardiac remodeling after TIPS, cardiovascular magnetic resonance showed stable myocardial tissue characteristics over follow-up timepoints. The findings suggest that early post-TIPS cardiac structural/functional changes may not necessarily reflect progressive myocardial tissue injury detectable by CMR.
Zange L, Gröschel J, Abdalla H et al. · European heart journal. Cardiovascular Imaging · (2026) · View on PubMed ↗
Myocardial remodeling and fibrosis by cardiovascular magnetic resonance in adults with congenital aortic valve stenosis.
This prospective cardiovascular magnetic resonance (CMR) study assessed myocardial remodeling before and after aortic valve replacement (AVR) in adults with congenital aortic valve stenosis, including patients with at least mild stenosis (Vmax ≥2.5 m/s) or prior AVR. The abstract indicates CMR was used to quantify structural LV remodeling and to identify markers associated with myocardial fibrosis, but the key quantitative findings are truncated. Establishing CMR fibrosis/remodeling markers in congenital aortic stenosis could improve risk stratification and monitoring of myocardial recovery after AVR.
Keuning ZA, van den Bosch AE, Barreto BL et al. · International journal of cardiology · (2026) · View on PubMed ↗
Imaging signatures of high-risk arrhythmogenic genotypes in dilated cardiomyopathy.
This prospective CMR-based study enrolled 90 dilated cardiomyopathy (DCM) patients stratified into high-risk arrhythmogenic variant carriers (HRAv; DSP, FLNC, LMNA, PLN; n=30), TTN truncating variant carriers (TTNtv; n=30), and genotype-negative patients (GN; n=30). It compared comprehensive CMR parameters across these genotype groups and used logistic regression to determine imaging signatures associated with high-risk arrhythmogenic genotypes, but the specific results are truncated. If validated, genotype-linked CMR phenotypes could enable earlier identification of arrhythmia-prone DCM patients for targeted surveillance and management.
Zhang Z, Li Y, Xu Y et al. · International journal of cardiology · (2026) · View on PubMed ↗
Heart failure with reduced ejection fraction: a systematic review of clinical practice guidelines and recommendations.
This systematic review evaluated international clinical practice guidelines for diagnosis and management of heart failure with reduced ejection fraction (HFrEF) in adults, using MEDLINE/EMBASE searches (10 Nov 2024) and AGREE II appraisal across 12 identified guidelines. Seven guidelines met AGREE II “rigour of development” criteria and showed broad consensus on core diagnostic and treatment recommendations for HFrEF. The synthesis supports harmonization of evidence-based HFrEF care and highlights where guideline methodology and recommendations may vary, informing clinicians and guideline developers.
Datta S, Majumder S, Gulsin GS et al. · European heart journal. Quality of care & clinical outcomes · (2026) · 3 citations · View on PubMed ↗ · Free PDF ↗
Late-onset radiation-induced myocardial fibrosis after lung cancer radiotherapy: correlation of cardiac MRI with radiation treatment planning CT.
This case report studied a 55-year-old man with prior left circumflex (LCx) ST-elevation myocardial infarction (STEMI) who developed late-onset radiation-induced myocardial fibrosis after lung cancer external beam radiotherapy. Cardiac MRI showed nonischemic late gadolinium enhancement (LGE), valvular thickening, and pericardial effusion, and correlation with radiation treatment planning CT supported radiation-induced myocardial fibrosis despite the prior STEMI history. The significance is that CMR plus treatment-planning CT can distinguish radiation injury from prior ischemic scar, guiding appropriate long-term management.
Masuodi B, Kataria S · The international journal of cardiovascular imaging · (2026) · View on PubMed ↗
Cardiac magnetic resonance imaging predictors of outcomes in noncompaction cardiomyopathy: A systematic review and meta-analysis.
This systematic review and meta-analysis studied cardiac MRI (CMR) predictors of outcomes in left ventricular noncompaction cardiomyopathy (NCCM) by comparing CMR structural parameters between NCCM patients and controls and assessing associations with major adverse cardiovascular and cerebrovascular events (MACCE). It found that reported CMR-derived measures in NCCM show inconsistent relationships with MACCE across included case-control studies, prompting a pooled evaluation of which imaging characteristics may be prognostically informative. Scientifically, the work clarifies which CMR features are most likely to stratify risk in NCCM, supporting more evidence-based prognostication.
Gegenava M, Nieman K, Caliskan K et al. · The international journal of cardiovascular imaging · (2026) · View on PubMed ↗
Cardiac MRI (CMR) Mechanics, Flow & Advanced Quantification
Physics-Informed Reconstruction of Transmural Myocardial Deformation from 3D Echocardiography: Validation Against Cardiac MRI.
This methodological study developed a physics-informed reconstruction framework to estimate transmural myocardial deformation by reconstructing the full finite strain tensor from 3D echocardiography, and validated it against cardiac MRI in a small cohort. The key result was that the reconstructed transmural deformation measures agreed with cardiac MRI-based reference deformation, demonstrating feasibility of the approach for capturing out-of-plane transmural mechanics. If validated in larger studies, this could improve clinical quantification of myocardial mechanics beyond conventional 2D/standard 3D echocardiography.
Pradhan SP, Yavari A, Lindley ID et al. · Annals of biomedical engineering · (2026) · View on PubMed ↗
Correlation of seismocardiography variables with echocardiographic and cardiac magnetic resonance measurements.
This study evaluated correlations between wearable seismocardiography (SCG) markers and cardiac function measures from transthoracic echocardiography (TTE) and cardiac magnetic resonance (CMR) in 26 adults (healthy and cardiovascular disease cohorts). SCG variables showed measurable associations with systolic and diastolic function parameters derived from TTE/CMR. These findings support SCG as a potentially low-cost, noninvasive adjunct for cardiac function assessment, pending larger validation across disease phenotypes.
Agam A, Korsgaard E, Kragholm K et al. · Biomedical physics & engineering express · (2026) · View on PubMed ↗ · Free PDF ↗
Toward self-contained cardiac magnetic resonance elastography: Deep learning-based segmentation of the left ventricular myocardium.
This study evaluated deep learning methods for automated segmentation of the left ventricular myocardium using cardiac magnetic resonance elastography (MRE) data, aiming toward a self-contained cardiac MRE workflow without manual annotation or additional structural MRI. Using cardiac MRE data from 16 healthy male volunteers, the key finding was that segmentation performance depends on input representation and the degree of automation strategy, informing how to design fully automated pipelines. Scientifically, it advances reproducible, scalable LV stiffness assessment by reducing operator dependence in cardiac MRE analysis.
Atamaniuk V, Anders M, Obrzut M et al. · Magnetic resonance imaging · (2026) · View on PubMed ↗ · Free PDF ↗
Systolic Septal Curvature Ratio as a Cardiac MRI Marker of Right Ventricular Loading in Pediatric Congenital Heart Disease.
This retrospective study evaluated the cardiac MRI-derived systolic septal-to-free wall curvature ratio as a marker of right ventricular (RV) loading in 149 pediatric patients (2020–2025) across congenital heart disease subgroups with different loading conditions. It found that septal curvature geometry on MRI (via the systolic septal curvature ratio) varied with RV loading and correlated with volumetric, functional, and hemodynamic parameters more specifically than standard global remodeling metrics. This provides a practical CMR marker to quantify RV loading-related interventricular mechanics in pediatric congenital heart disease, potentially improving assessment and follow-up.
Yucel IK, Kose KB, Ozyılmaz I et al. · Pediatric cardiology · (2026) · View on PubMed ↗
Autonomous Velocity Encoding (VENC) Selection Improves Precision of Quantitative Flow Measurement.
This study evaluated an autonomous workflow for selecting the optimal velocity encoding (VENC) in phase-contrast MRI to improve quantitative flow measurement precision without technologist input. Using retrospective scans (254 scans from 113 patients plus 18 healthy volunteers) and a prospective cohort of patients with abnormal flow, it found that autonomous VENC selection can improve measurement precision and potentially reduce scan time by better matching VENC to subject-specific peak velocities and flow-jet characteristics. The clinical significance is more reliable, faster quantitative flow MRI for assessing cardiovascular hemodynamics.
Daudé P, Ramasawmy R, Mancini C et al. · Journal of magnetic resonance imaging : JMRI · (2026) · View on PubMed ↗ · Free PDF ↗
Echocardiography/Multimodal Imaging for Rare Cardiac Conditions
Multimodality Imaging of a Massive Intrapericardial Mediastinal Hemangioma: A Diagnostic Challenge.
This JACC Case Reports article presents a 68-year-old man with a massive intrapericardial mediastinal hemangioma who had a severe iodinated contrast allergy. To avoid iodinated contrast, clinicians used an iodine-free multimodality strategy combining 2’-deoxy-2’-[F-18] fluoro-D-glucose PET/CT, cardiac magnetic resonance, and contrast-enhanced ultrasound, guided by 3D reconstruction for surgical planning. The clinical significance is demonstrating a practical diagnostic and operative pathway for thoracic/cardiac masses when iodinated contrast is contraindicated.
Weng J, Han J, Mao Y et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗
Membranous Interventricular Septal Aneurysm (MVSA) as a rare potential cause of embolic stroke: a case report and literature review.
This case report and literature review investigated membranous interventricular septal aneurysm (MVSA) as a rare cardioembolic source of stroke in a 42-year-old woman with recurrent cortical ischemic strokes. After an exhaustive diagnostic work-up found no alternative embolic source, MVSA was identified as the likely cause, and the authors reviewed similar reported cases to characterize clinical and radiological features. Clinically, recognizing MVSA in cryptogenic/recurrent embolic stroke can prompt appropriate cardiac evaluation and management to prevent recurrence.
Mariotti G, Lanfranconi S, Spaziani C et al. · Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · (2026) · View on PubMed ↗
Osteosarcoma in a Young Patient: When the Tumor Reaches the Heart.
This JACC Case Reports article describes a 17-year-old boy with prior osteosarcoma who developed cardiac metastasis presenting with dyspnea and palpitations. Transthoracic echocardiography and cardiac magnetic resonance (including late gadolinium enhancement) identified a mobile intracardiac mass, and surgical pathology confirmed metastatic osteosarcoma. The case underscores that cardiac metastasis from osteosarcoma, though rare, should be considered when imaging reveals intracardiac masses with malignant features.
Melem IC, Baratta SJ, Gutierrez G et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗
Radiation-Associated Mesothelioma With Mixed Constrictive-Restrictive Physiology After Mantle-Field Radiotherapy.
This case report describes a 60-year-old woman with radiation-associated mesothelioma decades after mantle-field radiotherapy for Hodgkin lymphoma who developed mixed constrictive–restrictive physiology. Echocardiography and cardiac catheterization suggested constrictive physiology, while cardiac magnetic resonance was nondiagnostic; PET-CT demonstrated hypermetabolic pleural, mediastinal, and pericardial lesions consistent with malignancy. The report emphasizes that late post-radiation malignancy can produce complex cardiothoracic hemodynamics and may require multimodality imaging for diagnosis.
Bensaber R, Serratrice J, Poku NK · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗
Beyond Echocardiography: Multimodality Imaging of a Mitral Valve Blood Cyst in Cryptogenic Stroke.
This case report described a 52-year-old woman with acute ischemic stroke in whom echocardiography identified a thin-walled, mobile mitral valve cystic mass and hypertrophic obstructive cardiomyopathy. The key finding was that noncontrast cardiac MRI showed the cyst’s internal signal was isointense with the left ventricular blood pool throughout the cardiac cycle, which definitively distinguished a blood cyst from solid neoplasms and caseous mitral annular calcification. The clinical significance is that multimodality imaging—especially cardiac MRI—can prevent misdiagnosis and inappropriate management of rare mitral valve lesions causing embolic stroke.
Güleşir ME, Topal B, Uğraş UA et al. · Journal of clinical ultrasound : JCU · (2026) · View on PubMed ↗
When chest pain and troponin elevation aren’t acute coronary syndrome: a cardiovascular case report of atypical pheochromocytoma.
This cardiovascular case report studied a 44-year-old woman with atypical pheochromocytoma presenting with chest pain and markedly elevated high-sensitivity troponin, initially mimicking non-ST-segment elevation myocardial infarction. Urgent coronary angiography showed angiographically normal coronary arteries, redirecting the diagnostic workup toward pheochromocytoma. The clinical significance is that catecholamine-secreting tumors can present as ACS-like syndromes, so clinicians should consider pheochromocytoma when troponin elevation occurs with non-obstructive coronaries.
Achour F, Cherkaoui S, Zarzour J et al. · European heart journal. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗
Relapsing-Remitting Perimyocarditis and Emerging Acute Myeloid Leukemia.
This case report studied relapsing-remitting perimyocarditis as an initial presentation of acute myeloid leukemia (AML) in a 66-year-old man after Coxsackievirus B exposure. Initial CMR and work-ups were negative, but repeat CMR demonstrated biventricular dysfunction with new lateral wall late gadolinium enhancement, myocardial edema, and circumferential pericardial effusion, and endomyocardial biopsy confirmed severe lymphocytic myocarditis. The significance is that recurrent “viral-like” perimyocarditis with evolving CMR findings should prompt consideration of underlying hematologic malignancy such as AML, even when early tests are unrevealing.
Zipperer-Giblin MB, Bowman JI, Patel N et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗
Cardiac Amyloidosis (Diagnosis, Monitoring, Mechanisms, Therapy)
Vutrisiran Treatment and Changes in Cardiac Parameters and Amyloid Burden Assessed by Cardiovascular MRI.
This JAMA Cardiology analysis evaluated how vutrisiran treatment (an RNA interference therapeutic suppressing hepatic TTR production) was associated with changes in cardiac structure/function and amyloid burden measured by multiparametric cardiovascular magnetic resonance (CMR) in transthyretin amyloid cardiomyopathy (ATTR-CM). The study leveraged CMR tissue characterization, including extracellular volume (ECV) mapping, to track cardiac amyloid load after treatment, but the abstract excerpt is truncated before reporting the main effect size. Demonstrating CMR-detected amyloid and cardiac parameter changes with vutrisiran would support CMR as a mechanistic and clinical monitoring tool in ATTR-CM trials and practice.
Razvi Y, Sheikh A, Patel RK et al. · JAMA cardiology · (2026) · View on PubMed ↗
p.(V142I)-Associated Variant Transthyretin Amyloid Cardiomyopathy Complicating Complex Congenital Heart Disease: A Lethal Combination.
This JACC Case Reports article describes a 51-year-old Nigerian man with complex congenital heart disease (double outlet right ventricle) who developed variant transthyretin amyloid cardiomyopathy (ATTRv-CM). Cardiac amyloidosis was suspected on echocardiography and confirmed using cardiac magnetic resonance and bone scintigraphy, with genetic sequencing later identifying homozygosity for the p.(V142I) transthyretin variant. The case highlights a lethal genotype–phenotype combination (p.(V142I) ATTRv-CM with complex congenital heart disease) and supports early multimodality evaluation when amyloidosis is suspected.
Zathar Z, Choy CH, Al-Sakini N et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗
Vitronectin-driven amyloid deposition disrupts mitochondrial homeostasis via integrin-mediated pathway in a humanized mouse model of transthyretin cardiac amyloidosis.
This preclinical study used humanized knock-in mice expressing wild-type transthyretin (hTTRWT) or the V142I mutant (hTTRV142I) to test whether vitronectin (VTN)-driven amyloid deposition disrupts mitochondrial homeostasis via an integrin-mediated pathway in transthyretin cardiac amyloidosis. The authors reported that VTN-associated amyloid deposition impaired mitochondrial homeostasis and worsened cardiac structure/function, with mechanistic support for an integrin-dependent signaling route. These results identify a potential VTN–integrin–mitochondria axis as a therapeutic target for ATTR cardiac amyloidosis.
Qiu Z, Fan Y, Qin J et al. · European heart journal · (2026) · View on PubMed ↗
First Successful Cardiac Myosin Inhibitor Use for Donor-Derived HCM After Heart Transplant.
This case report describes the first successful use of the cardiac myosin inhibitor mavacamten (Camzyos) for donor-derived hypertrophic cardiomyopathy (HCM) after heart transplantation in a 55-year-old woman. After postoperative day 1 onset of severe dynamic left ventricular outflow tract obstruction and persistent gradients despite calcium channel blocker and later beta-blocker therapy, cardiac magnetic resonance confirmed donor-derived HCM and mavacamten was initiated. The clinical significance is that mavacamten may offer an effective, earlier therapeutic option for rare post-transplant donor-derived HCM with severe obstruction.
Mohammed HA, Pillai A, Scatola A et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗
False-negative 99mTc-PYP bone scintigraphy in early cardiac amyloidosis: a rapidly progressive case in a young woman.
This case report studied a 33-year-old woman with dyspnea in whom early cardiac amyloidosis was suspected by echocardiography and cardiac magnetic resonance showing left ventricular hypertrophy. Despite suspicion, technetium-99m pyrophosphate (99mTc-PYP) bone scintigraphy was initially false-negative, and 14 months later repeat imaging showed Grade 2 uptake leading to a diagnosis of cardiac amyloidosis. The clinical significance is that early 99mTc-PYP negativity does not exclude cardiac amyloidosis in young patients, so repeat testing and ongoing evaluation may be necessary.
Polat E, Güler Ö, Güngör C · Cardiovascular journal of Africa · (2026) · View on PubMed ↗ · Free PDF ↗
Iron overload cardiomyopathy.
This review studied iron overload cardiomyopathy (IOC) in patients with hereditary haemochromatosis and transfusion-dependent haemoglobinopathies, focusing on cellular iron entry and downstream injury pathways. It found that excess non-transferrin-bound iron enters cardiomyocytes via L-type/T-type calcium channels, divalent metal transporter 1 (DMT1), and ZIP14, driving oxidative stress (Fenton reaction), mitochondrial dysfunction, calcium dysregulation, and ferroptosis. Scientifically and clinically, defining these mechanisms supports targeted diagnostic strategies and potential pathway-directed therapies to reduce morbidity and mortality in IOC.
Papingiotis G, Mantzourani M, Gogas H et al. · Heart failure reviews · (2026) · View on PubMed ↗
Cardiac Amyloidosis: Pathogenesis, Diagnosis, and Treatment.
This narrative review studied the pathogenesis, diagnosis, and treatment of cardiac amyloidosis, emphasizing systemic protein misfolding into beta-pleated sheet fibrils and interstitial deposition that impairs organ function. It found that the most common cardiac-involving systemic types are light-chain (AL) and transthyretin (ATTR) amyloidosis, and it summarized contemporary diagnostic evaluation and recent therapeutic developments. Clinically, consolidating diagnostic and treatment advances supports earlier recognition and more effective management of a condition with substantial population-level prevalence.
Beckmann S, Akin I, Haghikia A et al. · Deutsches Arzteblatt international · (2026) · View on PubMed ↗
Heart Failure (HFpEF/HFrEF) Phenotyping & Pathophysiology
Dilated Cardiomyopathy in a Woman With SPG4-Associated Hereditary Spastic Paraplegia.
This case report studied a 54-year-old woman with genetically confirmed SPG4-associated hereditary spastic paraplegia (SPG4-HSP) who developed dilated cardiomyopathy. Echocardiography and cardiac magnetic resonance demonstrated nonischemic dilated cardiomyopathy with reduced ejection fraction and dyssynchrony, while extended cardiomyopathy gene testing was negative. The findings suggest SPG4-HSP may have clinically relevant systemic cardiac involvement and support routine cardiac evaluation in such patients.
Gude S, Kleiven Ø, Edvardsen T · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗
Multiple manifestations of coronary microvascular dysfunction in a double-hit mouse model of HFpEF.
In a double-hit mouse model of heart failure with preserved ejection fraction (HFpEF), C57BL/6 mice were induced by high-fat diet plus chronic nitric oxide synthase inhibition (L-NAME) and then phenotyped for coronary microvascular dysfunction (CMD) using multimodal non-invasive imaging. The study found multiple CMD manifestations detectable by cine/strain cardiac MRI, dynamic contrast-enhanced MRI using galbumin and a redox-sensitive agent (3CP), and Doppler-based coronary flow reserve with vasodilator challenges, with corroboration by ex vivo coronary micro-CT angiography and transmission electron microscopy. This mechanistic, imaging-resolved platform advances early CMD phenotyping in HFpEF and can support targeted therapeutic testing.
Kwiatkowski G, Tyrankiewicz U, Mosiołek S et al. · Vascular pharmacology · (2026) · View on PubMed ↗
New perspectives on chagasic cardiomyopathy: A narrative review of genetics, magnetic resonance imaging and therapeutic alternatives.
This narrative review summarized evidence (2020–2026) on chagasic cardiomyopathy, focusing on how genetic variants relate to disease severity, the diagnostic utility of cardiac magnetic resonance imaging, and therapeutic alternatives including trypanocidal and advanced support treatments in endemic settings such as Peru. It reports that current data challenge a simple link between parasite lineage and cardiac severity, instead implicating the host inflammatory response as the primary driver. The significance is improved risk stratification and diagnostic strategy for American trypanosomiasis–related cardiomyopathy, potentially guiding more effective management pathways.
Velasco Hurtado JM, Quispe Zavala D, Vilela Luchini C et al. · Medwave · (2026) · View on PubMed ↗ · Free PDF ↗
Left Atrial Myopathy as a Phenotypic Axis in HFpEF: Implications for Pulmonary Hypertension, Exercise Intolerance, and Targeted Therapy.
This review examined left atrial (LA) myopathy as a mechanistic and phenotypic axis in patients with heart failure with preserved ejection fraction (HFpEF), focusing on implications for pulmonary hypertension and exercise intolerance. It found that LA myopathy involves structural remodeling, fibrosis, impaired compliance, and electrical dysfunction and may be central to HFpEF heterogeneity rather than only a consequence of elevated left-sided filling pressures. Clinically, this supports targeted therapy development aimed at LA myopathy to improve outcomes in HFpEF subgroups.
Jabeen M, Younas S, Majid A et al. · Cardiology in review · (2026) · View on PubMed ↗
Left Atrial Myopathy Across the Spectrum of Pediatric Heart Disease: Imaging, Mechanobiology, and Clinical Consequences.
This review studied left atrial (LA) myopathy across pediatric heart disease, synthesizing evidence from pediatric imaging (including speckle-tracking echocardiography) and mechanobiology to relate LA structure and mechanics to clinical outcomes. It found that LA dysfunction—often detectable before overt ventricular failure—reflects early, potentially reversible cardiovascular injury and can modulate ventricular filling, pulmonary venous pressures, cardiac output, and neurohormonal signaling. Clinically, recognizing LA biomechanical impairment in children may improve early risk stratification and guide monitoring for progression in congenital and acquired pediatric cardiac conditions.
Muqaddas R, Nawaz S, Ali S et al. · Cardiology in review · (2026) · View on PubMed ↗
Arrhythmias & Electrophysiology (including VT/SVT/SCD risk)
Extensive spontaneous coronary artery dissection complicated by ventricular tachycardia storm and cardiogenic shock.
This BMJ Case Reports article describes a clinical case of extensive spontaneous coronary artery dissection (SCAD) of the left anterior descending artery complicated by ventricular tachycardia storm and cardiogenic shock in a man in his 40s presenting with ST-segment elevation myocardial infarction. The patient was managed conservatively but required repeated direct-current cardioversions, intravenous amiodarone and lidocaine, and intra-aortic balloon pump support due to refractory instability. The report highlights the potential for life-threatening arrhythmias and shock in extensive SCAD and underscores the need for rapid escalation of supportive and antiarrhythmic care.
Ng YW, Hill L, Smyth AI et al. · BMJ case reports · (2026) · View on PubMed ↗
Occult Idiopathic Ventricular Fibrillation After Preoperative Cardiovascular Evaluation.
This case report describes a 50-year-old man who developed occult idiopathic ventricular fibrillation shortly after preoperative cardiovascular clearance for elective surgery. Despite extensive evaluation including coronary angiography, cardiac magnetic resonance, electrophysiological study, and genetic testing, no structural heart disease or inherited arrhythmia syndrome was identified, and a dual-chamber implantable cardioverter-defibrillator was implanted. The report highlights the need for vigilance for malignant arrhythmias even after “normal” preoperative workups when idiopathic ventricular fibrillation is suspected.
Ganthan RR, Isber R, Elcicek A et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗
LGL-Phenocopy With Dual AV Nodal Physiology and Malignant SVT: A Diagnostic Pitfall With Sudden Deaths.
This JACC Case Reports article described a 45-year-old man presenting with malignant supraventricular tachycardia (SVT) and a short PR interval without preexcitation (Lown-Ganong-Levine phenocopy), with family history of sudden cardiac death in three siblings. The key finding was that ECG during symptoms showed SVT (~220 bpm) with Hisian extrasystole and QRS variability, and post-conversion ECG revealed short PR with dual atrioventricular nodal physiology—demonstrating that this “phenocopy” can be associated with malignant substrates. Clinically, it underscores the need for careful evaluation of short-PR phenotypes rather than assuming benignity, especially when sudden death risk is present.
Negm AY, Zhfan S, Khalil M et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗
Feasibility and Safety of Strategic Multielectrode Positioning Guided by S3 Protocol for Hemodynamically Unstable Ventricular Tachycardia: The S3-STaMP Project.
This study evaluated the feasibility and safety of Strategic Multielectrode Positioning (STaMP) mapping guided by the S3 protocol in 30 patients undergoing scar-related ventricular tachycardia (VT) ablation with hemodynamically unstable, nontolerated VT. The key finding was that STaMP/S3 functional mapping enabled rapid identification of diastolic components of VT circuits in unstable settings, supporting procedural feasibility and safety in this high-risk population. Scientifically, it advances mapping strategies for VT ablation when conventional approaches are limited by hemodynamic collapse.
Pittorru R, Rosseel T, Pierucci N et al. · JACC. Clinical electrophysiology · (2026) · View on PubMed ↗
Compound MYH7 Mutations: Risk Stratification Challenges in an Affected Family.
This JACC case report studied a 54-year-old man from a familial hypertrophic cardiomyopathy (HCM) pedigree undergoing sudden cardiac death (SCD) risk stratification, alongside his daughter’s genotype-positive obstructive HCM. The key finding was that the daughter carried two pathogenic MYH7 variants (Ala655Thr and Gly571Arg) while the father carried only Ala655Thr, yet the father had mild septal hypertrophy and nonsustained ventricular tachycardia. The report underscores challenges in SCD risk stratification for compound MYH7 mutations and genotype-positive individuals with borderline phenotypes.
Hammad A, Yeung A, Goldschmidt H et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗
Exercise-induced ventricular arrhythmias: a marker of risk in arrhythmogenic cardiomyopathy.
This retrospective study evaluated exercise-induced ventricular arrhythmias (EIVAs) as a risk marker in patients with arrhythmogenic cardiomyopathy (ACM), including individuals with a pathogenic/likely pathogenic (P/LP) gene variant and negative or borderline phenotype. It found that EIVAs during exercise testing were prevalent and carried prognostic significance, with patients stratified into lower versus higher exercise intensity groups after diagnosis. The scientific significance is that exercise testing can unmask latent electrical instability in ACM and improve risk stratification beyond resting phenotype.
Mengozzi L, Sriskandarajah R, Minopoli C et al. · Heart (British Cardiac Society) · (2026) · View on PubMed ↗
Valvular Heart Disease (TR/AVR) & Structural Interventions
Percutaneous and Surgical Left Atrial Appendage Occlusion in Non-Valvular Atrial Fibrillation: Contemporary Narrative Review.
This contemporary narrative review synthesized evidence on left atrial appendage occlusion (LAAO) performed surgically (S-LAAO) or percutaneously (pLAAO) in non-valvular atrial fibrillation patients, focusing on randomized trials and systematic reviews. It highlights comparative gaps in direct evidence while summarizing procedural safety, thromboembolic outcomes, and imaging-based completeness of left atrial appendage exclusion. Clinically, clarifying how S-LAAO and pLAAO compare can guide selection of LAAO approach for AF patients who cannot take oral anticoagulation.
Chestaro JA, Price H, Matthews J et al. · Current problems in cardiology · (2026) · View on PubMed ↗
Tricuspid regurgitation: standardized stepwise work-up from referral to expert heart valve centre.
This review studied a standardized stepwise work-up for tricuspid regurgitation (TR) from referral to an expert heart valve centre, integrating etiology, disease stage, comorbidities, operative risk, and anatomical feasibility. It found that structured multimodal assessment and algorithm-driven referral improve selection of appropriate surgical versus transcatheter strategies in a condition historically managed conservatively. The clinical significance is better alignment of treatment choice with patient-specific risk and anatomy, aiming to improve outcomes in TR.
Dreyfus J, Praz F, Hahn R et al. · European heart journal · (2026) · 2 citations · View on PubMed ↗ · Free PDF ↗
Coronary Artery Disease (CAD) Imaging, Plaque Biology & Thromboembolism
Intracardiac Thrombi Mimicking Cardiac Metastases in a Patient With Lung Adenocarcinoma.
This case report studied a 50-year-old man with newly diagnosed lung adenocarcinoma and venous thromboembolism who developed two right-sided intracardiac masses despite therapeutic anticoagulation. Cardiac magnetic resonance suggested cardiac metastases, but histopathology of the excised atrial mass showed an organizing thrombus and the remaining ventricular lesion resolved after 1 month of therapeutic enoxaparin. The report highlights that cancer-associated intracardiac thrombi can mimic metastatic disease on CMR, emphasizing the need for tissue diagnosis and careful anticoagulation response assessment.
Lembo M, De Vivo R, La Mura L et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗
Characterization of intraplaque haemorrhage in statin-treated patients with stable coronary artery disease: multi-modality imaging with non-contrast T1-weighted cardiac magnetic resonance, optical coherence tomography, and near-infrared spectroscopy.
This multimodality imaging study characterized intraplaque hemorrhage in 121 statin-treated patients with stable coronary artery disease by using non-contrast T1-weighted cardiac magnetic resonance (CMR), optical coherence tomography (OCT), and near-infrared spectroscopy (NIRS)/intravascular ultrasound (IVUS). It found that plaque-to-myocardium ratio (PMR) ≥1.0 lesions—histologically validated to correspond to intraplaque hemorrhage—still exhibited residual intraplaque hemorrhage features despite ongoing statin therapy. Scientifically, it refines understanding of why CMR-detected intraplaque hemorrhage persists under lipid-lowering treatment and may inform imaging-based risk assessment.
Nakata J, Hosoda H, Kataoka Y et al. · European heart journal. Imaging methods and practice · (2026) · View on PubMed ↗ · Free PDF ↗
Vascular Biology & Risk (Aortic stiffness, OSA, vascular aging)
CMR-based aortic stiffness parameters in a symptomatic high risk obstructive sleep apnea cohort: results from the population-based Hamburg City Health Study.
This population-based Hamburg City Health Study analysis used CMR-derived aortic stiffness parameters—pulse wave velocity (PWV), ascending/descending aortic distensibility (AD AoAsc/AD AoDesc), and pulse pressure (PP)—to test associations with symptomatic high-risk obstructive sleep apnea (OSA). The study found relationships between OSA status and aortic stiffness measures, supporting OSA as a vascular aging risk factor detectable by CMR. These results strengthen the case for using CMR vascular biomarkers to identify and monitor cardiovascular risk in OSA.
Riedl KA, Reuter K, Böttcher A et al. · BMC cardiovascular disorders · (2026) · View on PubMed ↗
Immunotherapy & Cancer-Related Cardiac/Oncology Imaging
Prognostic value of different metabolic response criteria in patients with advanced melanoma treated with immunotherapy: a comparative analysis of PECRIT, PERCIMT, and EORTC criteria.
This retrospective study evaluated prognostic performance of [18F]FDG-PET/CT metabolic response criteria (PECRIT, PERCIMT, and EORTC) in patients with advanced melanoma treated with immune checkpoint inhibitors (ICIs). Across baseline and interim PET/CT scans, the study compared how per-patient metabolic response categories (CMR/PMR/SMD/PMD) predicted outcomes under each criterion. These findings help standardize PET/CT response assessment in ICI-treated melanoma, potentially improving risk stratification and treatment monitoring.
Di Giorgio A, Comito F, Bonazzi N et al. · European journal of nuclear medicine and molecular imaging · (2026) · View on PubMed ↗
Targeted Cancer Therapeutics & Resistance Mechanisms
Targeted KRASG12V Degradation In Vivo Elicits Lung Adenocarcinoma Regression with Subsequent Relapse from Dysregulated Proteolysis.
This preclinical study used a lung adenocarcinoma mouse model to test targeted degradation of KRASG12V via a PROTAC-like approach, examining tumor regression and subsequent relapse mechanisms. Targeted KRASG12V degradation produced rapid, cancer cell-autonomous tumor regression, but transcriptional/histologic/immunophenotypic analyses indicated dysregulated proteolysis associated with relapse after initial response. The work supports KRAS-targeting PROTAC strategies as a mechanistically grounded alternative to KRAS inhibition while highlighting proteolysis-related resistance risks.
Martín A, García-Pérez IM, San José S et al. · Cancer research · (2026) · 1 citations · View on PubMed ↗ · Free PDF ↗
Microbiome & Metabolic/CV Risk Biomarkers
Gut microbiota-derived imidazole propionate predicts cardiometabolic risk in patients with coronary artery disease.
This study measured circulating gut microbiota-derived imidazole propionate (ImP) and evaluated its prognostic value for cardiometabolic outcomes in patients with coronary artery disease using independent prospective cohorts of acute coronary syndrome (ACS) and chronic coronary syndrome (CCS). Higher ImP levels predicted worse cardiometabolic risk across these CAD cohorts, consistent with ImP’s proposed proatherogenic effects on myeloid inflammation, endothelial function, and glucose metabolism. ImP may serve as a microbiome-linked biomarker to refine risk prediction in CAD.
Wenzl FA, Wang P, Kahles F et al. · European heart journal · (2026) · 10 citations · View on PubMed ↗ · Free PDF ↗
Genome sequence of Propionimicrobium lymphophilum ARP01 isolated from the human vaginal tract.
This genome announcement reports the whole-genome sequencing of Propionimicrobium lymphophilum strain ARP01 isolated from a vaginal swab of a healthy 52-year-old Caucasian woman. Sequencing was performed using Oxford Nanopore Technologies, producing a single-contig genome assembly of 2.2 Mbp. The dataset provides a reference genome that can support future studies of vaginal microbiome biology and potential clinical associations.
Peel AR, Churchill H, Hayward MR et al. · Microbiology resource announcements · (2026) · View on PubMed ↗ · Free PDF ↗
AI/Deep Learning for Cardiovascular Imaging & Risk Stratification
Artificial Intelligence in Cardiovascular Imaging and Risk Stratification: From Algorithmic Discovery to Meaningful Clinical Implication.
This review synthesized evidence on how artificial intelligence (AI)—including deep learning, foundation models, and multimodal integration—has been applied to cardiovascular imaging and risk stratification from 2023 to 2026. The key finding is that AI can automate quantitative, patient-specific interpretation that addresses limitations of operator-dependent, time-intensive manual imaging analysis and static population thresholds. Clinically, this positions AI as a pathway toward more scalable and meaningful cardiovascular risk assessment, though translation and validation remain central challenges.
Xia X, Khan WU, Khan Q et al. · Trends in cardiovascular medicine · (2026) · View on PubMed ↗
Imaging-Derived Sarcopenic Obesity and Cardiovascular Outcomes: Insights Into Heart Failure Risk and Muscle Biology.
This study investigated whether imaging-derived sarcopenic obesity measures predict cardiovascular outcomes, focusing on heart failure risk and muscle biology, using deep learning applied to cardiovascular imaging. The key finding was that a translatable deep learning pipeline quantifying pectoralis major muscle mass (to define sarcopenic obesity) provided prognostic insight beyond conventional obesity metrics. Scientifically and clinically, this supports muscle-aware phenotyping from routine imaging as a way to refine heart failure risk stratification and connect it to genomic/transcriptomic correlates.
Sanghvi MM, Nicholls HL, Kaplan TM et al. · Journal of the American College of Cardiology · (2026) · 1 citations · View on PubMed ↗
Diagnostic/Clinical Pathways, Guidelines & Safety
Cardiac safety of chronic inhibition of the myostatin-activin pathway with bimagrumab in healthy older adults.
This randomized, double-blind, placebo-controlled trial evaluated the cardiac safety of chronic inhibition of the myostatin-activin pathway with bimagrumab in 68 healthy older adults (60–86 years) over 6 months with additional follow-up. The key finding was that extended pathway inhibition did not reveal major adverse changes in cardiovascular parameters compared with placebo during the study period. This supports the short-to-mid term cardiac safety profile of bimagrumab in an older adult population.
Rooks D, Yates DP, Neelakantham S et al. · The Journal of clinical endocrinology and metabolism · (2026) · 1 citations · View on PubMed ↗ · Free PDF ↗
Modified natural cycle versus hormone replacement therapy embryo transfer in women over 40 years old: a retrospective analysis.
This retrospective multicenter cohort study compared modified natural cycle embryo transfer (mNC-ET) versus hormone replacement therapy embryo transfer (HRT-ET) in 16,579 women aged ≥40 years undergoing single embryo transfer (SET) across 21 clinics in Spain and Italy (26,039 SETs; 2019–2023). The study evaluated live birth rate and other outcomes using euploid frozen transfers for autologous cycles and both fresh and frozen transfers for egg-donor cycles, but the provided abstract is truncated before reporting the key comparative results. If mNC-ET and HRT-ET differ in live birth or safety outcomes in women 40–49, this could directly inform endometrial preparation strategy for older patients undergoing IVF with SET.
Molinaro P, Napoleoni E, Alonso C et al. · Fertility and sterility · (2026) · View on PubMed ↗
Reperfusion Injury and Infarct Size: Why Translation has Been Difficult, and How We Move Forward.
This review article examined why cardioprotection strategies have been difficult to translate into clinical benefit in reperfused ST-elevation myocardial infarction (STEMI) and proposed a framework for future trials. It reports that contemporary cardioprotection studies in enriched STEMI cohorts have largely been neutral, including trials such as STEMI-DTU, PiCSO-AMI-I, EURO-ICE, and COOL AMI EU, with cardiovascular magnetic resonance (CMR) infarct size as an endpoint. The scientific significance is a roadmap for designing more actionable, pathway-informed cardioprotection trials rather than relying on prior translational assumptions.
Bulluck H, Hausenloy DJ · Current cardiology reports · (2026) · View on PubMed ↗
Myocarditis in the Modern Era: Navigating Diagnosis, Innovative Treatments, the COVID-19 Challenge and the Role of Artificial Intelligence.
This narrative review examined modern approaches to myocarditis diagnosis and treatment, including the impact of COVID-19 and the emerging role of artificial intelligence, across diverse etiologies (infectious, autoimmune, and drug-induced). It highlights that cardiac magnetic resonance (CMR) using the Lake Louise Criteria, supplemented by parametric imaging, has improved noninvasive diagnostic accuracy compared with reliance on invasive biopsy. The review’s significance is to guide clinicians toward updated diagnostic pathways and to frame how AI may augment interpretation and decision-making in myocarditis care.
Mohee K, Antoun I, Ambrogetti R et al. · Cardiology research and practice · (2026) · View on PubMed ↗ · Free PDF ↗
Data-source choice in diabetes mortality surveillance and equity monitoring in the United States, 1999-2023.
This epidemiologic study examined how choosing different data sources affects diabetes mortality surveillance and equity monitoring in the United States from 1999–2023 by comparing CDC WONDER versus Global Burden of Disease 2023 (GBD 2023) across 51 jurisdictions. The key finding was that mortality trend conclusions, identification of high-burden jurisdictions, and measures of income-related inequality could differ depending on the data source used. The clinical/public-health significance is that surveillance systems should account for data-source choice to avoid biased equity assessments and misdirected interventions.
Li WJ, Tao SS, Wang P et al. · Diabetes research and clinical practice · (2026) · View on PubMed ↗
Advanced Cardiac Imaging Techniques for Detection of Myocardial Ischemia in Children with Coronary Artery Abnormalities.
This review studied advanced cardiac imaging approaches for detecting myocardial ischemia in children with coronary artery abnormalities, covering non-atherosclerotic etiologies such as post–Kawasaki vasculopathy, transplant-related allograft vasculopathy, anomalous aortic origin of a coronary artery, and post–coronary reimplantation complications. It found that ischemia detection is uniquely challenging in pediatrics due to atypical or absent symptoms and limitations of traditional screening (e.g., resting ECG), motivating use of more advanced imaging modalities tailored to the specific coronary pathology. The clinical significance is improved diagnostic accuracy for pediatric ischemia, supporting earlier intervention and reducing risk of ventricular dysfunction and sudden cardiac death.
Jin JB, Williams JL, Wang SM et al. · Cardiology and therapy · (2026) · View on PubMed ↗ · Free PDF ↗
Methods/Devices/Engineering in Medicine (including spectroscopy, robotics, FSI, mapping)
Robust Audio-Visual Question Answering with Missing Modality in Training and Testing.
This paper studied robust audio-visual question answering (AVQA) under missing-modality conditions by introducing Training-time Modality-Missing AVQA (TM-AVQA), where audio-missing and/or visual-missing samples can occur during both training and testing. The key finding is that the proposed training/testing formulation improves AVQA robustness when one modality is absent, addressing practical failures such as hardware loss or privacy-driven removal. This advances multimodal model reliability for real-world dynamic-scene question answering.
Zhou J, Li Z, Hu D et al. · IEEE transactions on pattern analysis and machine intelligence · (2026) · View on PubMed ↗
Guiding Pacemaker Implantation With Multimodality Imaging in an Adult With Ventricular Septal Defect.
This JACC Case Reports article describes a 57-year-old adult with congenital ventricular septal defect and prior surgical repairs who developed complete heart block requiring pacemaker implantation. Multimodality imaging was used to plan the procedure by clarifying complex septal anatomy and identifying optimal lead positioning strategies to improve procedural safety. The significance is that imaging-guided planning can reduce technical difficulty and enhance safety in pacemaker placement for adults with congenital heart disease.
Singh AK, Eastwood C, Wong C · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗
Development and evaluation of a Raman detector for non-destructive identification and quantitation of cytostatic drugs in different primary packaging containers.
A dedicated Raman spectroscopy detector was developed and evaluated for non-destructive identification and quantitation of cytostatic drugs directly through closed primary packaging, tested on aqueous solutions of cyclophosphamide and gemcitabine at 1–45 mg/mL. The key finding was that Raman measurements enabled reliable detection and quantitation of these drugs in clinically relevant concentration ranges using sealed infusion glass containers. This supports improved hospital/community pharmacy quality control for personalized chemotherapy by reducing open handling while maintaining analytical accuracy.
Siegmund P, Klinken-Uth S, Michel A et al. · Journal of pharmaceutical and biomedical analysis · (2026) · View on PubMed ↗
Transcatheter atrial flow regulator implantation in children with pulmonary arterial hypertension in resource-limited settings: a single-centre experience.
This single-centre retrospective experience evaluated transcatheter atrial flow regulator implantation in six children with severe World Health Organization Group 1 pulmonary arterial hypertension in resource-limited settings. The key finding was that the atrial flow regulator was feasible to implant in this pediatric population where access to parenteral prostacyclin is often constrained, providing right-heart decompression via a controlled interatrial shunt. The significance is that this device-based strategy may offer a practical alternative to costly or logistically difficult chronic prostacyclin therapy in low-resource settings.
Das B, Maiya S, Khan B et al. · Cardiology in the young · (2026) · View on PubMed ↗
From Case Studies to Cohort of Patients: Automating FSI Simulations to Uncover Downstream Effects of Ascending Aortic Grafts.
This computational engineering study developed a fully automated patient-specific fluid-structure interaction (FSI) pipeline to assess downstream hemodynamic effects after ascending aortic grafting with a synthetic Dacron graft. The key finding was that graft–native compliance mismatch can be modeled to quantify altered hemodynamics that may contribute to downstream descending aortic dissection and adverse vascular remodeling. The significance is that automated FSI simulations can help predict post-operative risks and potentially guide grafting strategies to reduce downstream complications.
Ianniruberto I, Astori D, Saitta S et al. · Annals of biomedical engineering · (2026) · View on PubMed ↗ · Free PDF ↗
Learning curve of Versius-assisted radical prostatectomy: role of prior experience and proctoring.
This prospective cohort study assessed the learning curve for Versius-assisted radical prostatectomy in patients with localized prostate cancer, comparing surgeons with extensive prior robotic experience versus those with laparoscopic experience only under structured proctoring. The key finding was that prior robotic/laparoscopic experience and proctoring influenced objective proficiency metrics such as console time and novel hand motion measures. Clinically, it supports how training background and mentorship can accelerate safe adoption of the Versius robotic platform.
Fernández-Conejo G, González Álvarez C, Del Olmo Durán P et al. · BJU international · (2026) · View on PubMed ↗ · Free PDF ↗
Generated automatically on August 14, 2026. Covers PubMed articles published August 07, 2026 – August 14, 2026. Summaries are AI-generated; always consult the original publication for clinical or research decisions.