What’s New in Cardiac MRI?

September 03, 2026 · 92 articles · 15 research themes · covering August 27, 2026 – September 03, 2026

Overview

This week’s digest is dominated by a clear convergence of (1) advanced cardiac imaging—especially cardiac MRI—and (2) AI methods that make those images faster, more accurate, and more actionable. Multiple studies focus on improving CMR workflows (e.g., free-breathing cine in atrial fibrillation, deep-learning cine acceleration in pediatrics, and diffusion tensor imaging acquisition strategies), while others push the frontier of automated interpretation (segmentation, motion tracking, phase keyframe detection, and radiomics/risk modeling). Several papers also tackle the “real-world deployment” gap: query-shift robustness, clinician-facing report usability, and—critically—dataset bias and under-reporting of demographics/outcomes.

Clinically, the strongest theme is risk stratification and phenotype refinement across major cardiovascular syndromes. In hypertrophic cardiomyopathy, new CMR markers (quantified LGE burden, ECV, trabecular fractal dimension, and left atrial reservoir strain) continue to sharpen sudden-death and progression prediction, including work that integrates genetic context. In ischemic and microvascular disease, quantitative stress perfusion CMR reveals coronary microvascular dysfunction in MINOCA even when conventional imaging is normal, while studies of MI injury (intramyocardial hemorrhage, microvascular obstruction surrogates, and hemodynamic metrics) aim to better link mechanisms to outcomes. For heart failure and cardiomyopathy, imaging-derived indices and prognostic models are increasingly used to guide management decisions, including therapy de-escalation strategies in recovered HER2-related cardiac dysfunction and mechanistic analyses in dialysis-related remodeling.

Finally, the digest highlights how imaging is being used not only to predict outcomes, but also to improve diagnosis in complex or uncommon scenarios—ranging from rare cardiac tumors and infiltrative/systemic diseases (amyloidosis, sarcoidosis, Erdheim-Chester, scleroderma, mitochondrial phenocopies) to congenital heart disease physiology (Fontan and shunt-related hemodynamics, 5D flow energetics). Across these domains, the overarching message is that multimodality imaging plus better computational tools is moving cardiology toward earlier detection, more precise phenotyping, and more personalized risk-based care.

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Cardiac MRI for Diagnosis of Specific Cardiac Conditions (CMR phenotyping, masses, myocarditis, pericardial disease)

Angiomatoid Fibrous Histiocytoma: An Exceptionally Rare Pulmonary Artery Tumor Presenting as an Asymptomatic Heart Murmur.

This case report studied an exceptionally rare angiomatoid fibrous histiocytoma (AFH) presenting as a pulmonary artery tumor in a 28-year-old man with prior stage 3 Burkitt lymphoma in remission. Imaging with transthoracic echocardiography, cardiac magnetic resonance imaging, and positron emission tomography-computed tomography identified a 1.9 cm hyperintense mass attached to the pulmonic valve and main pulmonary artery wall, leading to surgical resection of the main pulmonary artery and pulmonic valve. The clinical significance is that AFH should be considered in the differential diagnosis of pulmonary artery tumors presenting with new heart murmurs, even in patients without established risk factors.

Jafary Z, Rana S, Vaughan M et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗

Successful repair of a rare submitral aneurysm with basal septal defect: a technique combining edge-to-edge repair and patch exclusion.

This 2026 case report described successful surgical repair of a rare submitral left ventricular aneurysm (SLVA) with a basal septal defect using a combined technique of edge-to-edge mitral repair and patch exclusion. In a 44-year-old man presenting with syncope and acute heart failure, multimodality imaging including cardiac magnetic resonance identified a large basal septal LV aneurysm with thick mural thrombus and severe secondary mitral regurgitation due to anterior leaflet tethering. The case demonstrates a feasible operative strategy to address both aneurysm risk (rupture/embolism) and mitral valve pathology while preserving ventricular geometry.

Sawant G, Aironi B, Agarwal A et al. · Indian journal of thoracic and cardiovascular surgery · (2026) · View on PubMed ↗ · Free PDF ↗

The role of artificial intelligence in the diagnosis of pericardial constriction.

This review summarized current evidence on artificial intelligence (AI) for diagnosing pericardial constriction, focusing on how AI may help distinguish constrictive pericarditis from restrictive cardiomyopathy. The key finding is that most established AI evidence uses machine learning/deep learning applied to echocardiography, with emerging approaches expanding to other imaging modalities and diagnostic workflows. The review is clinically significant because improved AI-assisted differentiation could reduce diagnostic delays and inappropriate management in patients with suspected constrictive pericarditis.

Lipat K, Booth T, Sengupta PP · Current opinion in cardiology · (2026) · View on PubMed ↗

Non-invasive detection of acute cell-mediated graft rejection in paediatric heart transplant recipients: The role of cardiovascular magnetic resonance.

This prospective study evaluated whether multiparametric contrast-enhanced cardiovascular magnetic resonance (CMR) can non-invasively detect acute cell-mediated graft rejection in 15 pediatric heart transplant recipients, using endomyocardial biopsy (EMB) and right heart catheterization as reference standards. The key finding was that multiparametric CMR and rejection-associated differences in textural features of parametric maps could distinguish rejection from non-rejection cases. Clinically, this supports a potential non-invasive alternative to EMB for monitoring acute rejection in children after heart transplantation.

Gesuete V, Ragni L, Niro F et al. · International journal of cardiology. Congenital heart disease · (2026) · View on PubMed ↗ · Free PDF ↗

Multidisciplinary approach in cardiac sarcoidosis: to biopsy or not?

This review studied the diagnostic role of endomyocardial biopsy (EMB) in patients with cardiac sarcoidosis, focusing on how it fits within a multidisciplinary framework given patchy myocardial involvement. It found that EMB’s historically “gold standard” status is limited by low sensitivity, false-negative/inconclusive results, and procedural risks, driving increasing reliance on noninvasive imaging. Clinically, the work supports a modern, imaging-led diagnostic strategy in which tissue diagnosis is selectively pursued rather than routinely required.

Pericao A, Sharma R · Current opinion in pulmonary medicine · (2026) · View on PubMed ↗

Pathway for the Diagnosis and Management of Pericardial Disease: Contemporary Perspective.

This article reviews and proposes a pathway-based diagnostic and management framework for pericardial disease across clinical scenarios (acute pericarditis, pericardial effusion, cardiac tamponade, and effusive-constrictive pericarditis) in adults, integrating contemporary European Society of Cardiology and American College of Cardiology guidance. It finds that structured phenotyping using multimodal imaging and targeted immunomodulatory therapies can standardize care, but real-world implementation remains variable. The clinical significance is that the proposed scenario-based pathway may improve timely diagnosis and treatment selection for urgent, heterogeneous pericardial presentations.

Sivalokanathan S, Herzog E, Haider SW et al. · Critical pathways in cardiology · (2026) · View on PubMed ↗ · Free PDF ↗

AngioVac aspiration as a combined diagnostic and therapeutic strategy for an indeterminate right atrial mass in a patient with malignancy.

This case report studied a woman with active primary mediastinal large B-cell lymphoma who had an indeterminate right atrial mass where thrombus versus malignant involvement could not be reliably distinguished by TTE, TEE, and cardiac MRI. The key finding is that catheter-directed aspiration with the AngioVac system achieved significant debulking and successful tissue retrieval without the need for high-risk surgical biopsy. The clinical significance is that AngioVac aspiration can serve as a combined diagnostic and therapeutic approach for right atrial masses in malignancy when conventional sampling is unsafe.

Abumuhfouz M, Sena A, Suleiman S et al. · Radiology case reports · (2026) · View on PubMed ↗ · Free PDF ↗

Cardiac lipoma of the right atrial appendage: Multimodality imaging of a rare tumor at an uncommon site.

This case report studied a 60-year-old woman in whom a small, mobile fat-containing cardiac mass was incidentally discovered in the right atrial appendage (RAA) during computed tomography pulmonary angiography for acute pulmonary embolism. Cardiac magnetic resonance imaging confirmed imaging features consistent with a cardiac lipoma at this uncommon RAA location. The report is clinically significant because it highlights multimodality imaging (CT angiography plus CMR) for diagnosing rare benign cardiac tumors that may be mistaken for embolic or malignant causes.

Kosum P, Tumkosit M, Jarutasnangkul L et al. · Radiology case reports · (2026) · 1 citations · View on PubMed ↗ · Free PDF ↗

Isolated Myocardial Metastases in a Neuroendocrine Tumor: 68 Ga-DOTATATE PET/CT and Cardiac Magnetic Resonance Imaging Findings.

This case report studied isolated myocardial metastases from a well-differentiated terminal ileum neuroendocrine tumor (NET; grade 1, Ki-67 1%) in a 58-year-old man using 68Ga-DOTATATE PET/CT and cardiac magnetic resonance imaging (CMR). 68Ga-DOTATATE PET/CT showed intense uptake in the primary tumor and two incidental myocardial foci, and CMR demonstrated corresponding heterogeneous myocardial signal consistent with metastases. The findings highlight that somatostatin receptor–based PET/CT can detect otherwise rare, isolated cardiac involvement at initial NET staging and that CMR can confirm it.

Baltacioglu MH, Sahin Oguz P · Clinical nuclear medicine · (2026) · View on PubMed ↗

A novel convolution-transformer model for differentiating hypertrophic cardiomyopathy from Phenocopies using cardiac MRI.

The study developed a cardiovascular magnetic resonance (CMR) foundation-model deep learning approach using a convolution-transformer to differentiate hypertrophic cardiomyopathy (HCM) from HCM phenocopies (hypertensive heart disease and cardiac amyloidosis) and normal controls on cardiac MRI. The model enabled accurate, automated classification among HCM, normal hearts, and HCM phenocopies despite substantial radiologic overlap. This could improve noninvasive diagnostic decision-making and reduce misclassification of inherited cardiomyopathy versus mimicking conditions in routine CMR workflows.

Guo X, Zhou S, Shen Y et al. · Magnetic resonance imaging · (2026) · View on PubMed ↗

Multimodal Detection of Subclinical Cardiovascular Disease in Chronic Kidney Disease.

The article reviewed and proposed multimodal detection strategies for subclinical cardiovascular disease (CVD) in patients with chronic kidney disease (CKD), focusing on imaging modalities such as echocardiography and coronary computed tomography angiography (CTA) alongside other clinical signals. The key finding was that subclinical CVD is highly prevalent in CKD yet frequently unrecognized, and multimodal approaches may enable earlier identification of vascular and cardiac remodeling before overt events. This is significant because earlier detection could allow timely intervention to reduce progression and the CKD-associated mortality gap.

Baek I, Parwani P, Gaznabi S et al. · Cardiorenal medicine · (2026) · View on PubMed ↗

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Non-cardiac/Environmental & Public Health (e.g., ozone/aerosols, diabetes surveillance, alcohol metabolism, adolescents)

Creating bottom-up RNA transfer vehicles from synthetic protein assemblies.

This Nature study investigated whether AI-designed synthetic protein assemblies can be engineered into bottom-up RNA transfer vehicles independent of viral evolutionary constraints. The key finding was that functional nucleic-acid transport systems can be constructed by combining designed protein architectures with nucleic-acid cargo to create virus-like delivery capabilities without relying on natural capsid evolution. Scientifically, it advances programmable, non-viral RNA delivery platforms built from rational protein design rather than evolutionary viral templates.

Schuhmacher MK, Gruber C, Lang CMR et al. · Nature · (2026) · View on PubMed ↗ · Free PDF ↗

Data-source choice in diabetes mortality surveillance and equity monitoring in the United States, 1999-2023.

This US surveillance study compared diabetes mortality conclusions across 51 jurisdictions from 1999–2023 using two data sources—CDC WONDER versus Global Burden of Disease (GBD) 2023—to test whether data-source choice changes trends, high-burden rankings, and income-related inequality. The key finding was that mortality estimates and derived equity metrics can differ depending on the chosen source, affecting which jurisdictions are classified as high burden and how inequality is quantified. The work is significant for public health policy because it shows that surveillance conclusions about diabetes mortality and equity are not fully interchangeable across data systems.

Li WJ, Tao SS, Wang P et al. · Diabetes research and clinical practice · (2026) · View on PubMed ↗

SMARCA4, STK11, and KEAP1 co-inactivation associates with poor prognosis and upregulation of the TGF-β pathway in lung adenocarcinoma.

This translational oncology study investigated how co-inactivation of SMARCA4, STK11, and KEAP1 affects prognosis and activates the TGF-β pathway in lung adenocarcinoma (LUAD). The key finding was that SMARCA4/STK11/KEAP1 co-inactivation was associated with poor prognosis and increased upregulation of TGF-β pathway signaling compared with other genetic contexts. Clinically, these results support using multi-gene alteration patterns to refine risk stratification and suggest TGF-β pathway targeting as a potential therapeutic direction for this LUAD subgroup.

Costa EA, Mello BP, Wohlhieter C et al. · Translational oncology · (2026) · View on PubMed ↗ · Free PDF ↗

Outcomes From the Multicenter ACCRU-LY-1804/CARiBOU TRIAL (Cytarabine, Acalabrutinib and Rituximab Integrated With Bortezomib-Based Outpatient Therapy) in 1st Line Mantle Cell Lymphoma.

This phase 2 multicenter ACCRU-LY-1804/CARiBOU trial evaluated first-line therapy in previously untreated mantle cell lymphoma (MCL) patients, using a regimen that alternates VR-CAP and R-cytarabine with continuous acalabrutinib and bortezomib-based outpatient therapy. The key finding is the trial’s reported outcomes for complete metabolic response (CMR) rate and secondary endpoints including safety/feasibility of stem cell collection, ASCT proportion, and progression-free and overall survival. The significance is that CARiBOU provides evidence for an integrated chemoimmunotherapy plus BTK inhibition strategy aimed at durable responses in frontline MCL.

Smith SD, Sundaram S, Giri S et al. · American journal of hematology · (2026) · View on PubMed ↗ · Free PDF ↗

Size-resolved microelectrical effects of fine aerosol on nocturnal ozone: Evidence from field observations and statistical modeling.

This field study examined how fine aerosol electrical properties relate to nocturnal ozone (O3) enhancement using summertime ground-based observations in Xi’an (2023–2025) and statistical modeling. It finds that particle charge-to-mass ratio (CMR) is associated with nocturnal O3 variations even under stable nocturnal atmospheric conditions, with relationships supported by generalized additive models (GAM), partial least squares structural equation modeling (PLS-SEM), and an interfacial contribution model. Scientifically, it suggests particulate electrical properties can contribute to nocturnal O3 chemistry beyond meteorological transport alone.

Wang Y, Zhang L, Li J et al. · Environmental research · (2026) · View on PubMed ↗

Reversible alterations of brain acetate metabolism associated with alcohol consumption.

This study examined reversible changes in brain acetate metabolism associated with alcohol consumption by comparing light drinkers, at-risk heavy drinkers, and two groups of alcohol use disorder (AUD) participants scanned at about one week abstinence after medically supervised detoxification. It built on prior findings by assessing whether abstinence reverses the previously observed shift toward increased brain acetate oxidation and reduced glucose uptake. The scientific significance is that brain acetate metabolism may serve as a reversible biomarker of alcohol-related metabolic effects in AUD.

Kumaragamage C, Jiang L, Angarita GA et al. · Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · (2026) · View on PubMed ↗ · Free PDF ↗

Subclinical Origins of Cardiometabolic Risk in Indian Adolescents: A Cross-Sectional Study.

This cross-sectional study measured cardiometabolic risk factors in apparently healthy Indian adolescents aged 11–16 years, relating them to whole-body fat (DXA) and hepatic fat (3.0T MRI proton density fat fraction, PDFF). A substantial proportion of adolescents showed at least one cardiometabolic risk factor, with body and hepatic fat associated with cardiometabolic risk. These findings suggest that subclinical cardiometabolic risk in Indian youth may originate from early increases in adiposity and liver fat, supporting earlier screening and prevention strategies.

Hegde SG, Kankara SR, Raj JM et al. · Indian pediatrics · (2026) · View on PubMed ↗

Intraoperative study of afferent and efferent connections in the upper lumbar spinal cord - Part 1: Cremasteric reflex.

This intraoperative neurophysiology study evaluated the feasibility and stimulation/recording parameters of the cremasteric reflex (CMR) in 15 male patients undergoing spinal surgery under general anesthesia. Ipsilateral upper medial thigh electrical stimulation produced cremasteric reflex responses in most recorded cremaster muscles, demonstrating an overall recordability rate of 76% with defined onset characteristics. The results support cremasteric reflex testing as a practical intraoperative tool for assessing upper lumbar spinal cord afferent/efferent pathway integrity.

de Melo DLM, Oliveira DRDCAB, Madureira PLDS et al. · Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · (2026) · View on PubMed ↗

Survival of patients with complete metabolic response on [18F]FDG PET/CT after chemotherapy prior to transplantation for colorectal liver metastases.

This study evaluated survival outcomes after liver transplantation for colorectal liver metastases in patients who achieved complete metabolic response (CMR; MTV=0) on pre-transplant [18F]FDG PET/CT following chemotherapy, using data from the SECA 1 and 2 studies (n=45). Patients with complete metabolic response had different disease-free survival, overall survival, and post-relapse survival compared with groups defined by low or high metabolic tumor volume (MTV). The findings support using PET/CT metabolic tumor volume to refine prognostication and potentially selection for transplantation in CRLM.

Stern NM, Dueland S, Line PD et al. · Scandinavian journal of surgery : SJS : official organ for the Finnish Surgical Society and the Scandinavian Surgical Society · (2026) · 1 citations · View on PubMed ↗ · Free PDF ↗

Hypothermia on trauma center arrival has a much greater impact on outcomes at the extremes of age.

This retrospective cohort study used the Trauma Quality Improvement Program database (2020–2023) to assess how arrival hypothermia affects outcomes across age extremes, categorizing patients by temperature (normothermia 36–38°C, mild 35–35.9°C, severe <35°C, and hyperthermia). The key finding was that hypothermia on trauma center arrival had a disproportionately greater impact on outcomes at the extremes of age (pediatric and geriatric patients). These results support age-tailored temperature management protocols to reduce morbidity and mortality in trauma.

Crosier CJ, Rempson CM, Green A et al. · The journal of trauma and acute care surgery · (2026) · View on PubMed ↗

Comparative study of robotic-assisted and uniportal video-assisted thoracic surgery: Insights from the introduction of Versius CMR surgical robot-Propensity score-matched analysis.

This propensity score–matched comparative study evaluated early outcomes of the Versius CMR Surgical robotic system versus uniportal video-assisted thoracic surgery (VATS) in thoracic surgery patients undergoing anatomical lung resections and thymectomies. The key finding was that early robotic-assisted performance during system introduction was assessed against uniportal VATS outcomes in a matched framework (124 robotic cases vs 229 VATS controls), focusing on early clinical endpoints. Scientifically and operationally, it informs how a new robotic platform performs during the learning phase compared with an established uniportal VATS approach.

Bakr L, Bakr S, Chaubey M et al. · Surgery · (2026) · 2 citations · View on PubMed ↗

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Systemic/Non-cardiac Disease with Cardiac Involvement (scleroderma, sarcoidosis, ECD, mitochondrial, etc.)

Depressed LV Contractility as a Sentinel of Fulminant Systemic Scleroderma.

This JACC Case Reports report studied fulminant systemic scleroderma in a 21-year-old man, focusing on depressed left ventricular (LV) contractility as a sentinel feature of cardiac involvement. Cardiac magnetic resonance showed diffuse gadolinium enhancement and endomyocardial biopsy demonstrated mast cell infiltration with early fibrosis, but despite guideline-directed medical therapy and subsequent cyclophosphamide, LV function rapidly deteriorated. Clinically, it highlights that early recognition of reduced LV contractility in systemic sclerosis may signal aggressive cardiac disease requiring urgent escalation.

Luo M, Branch T, Vasoya D et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗

Cardiac-Predominant Fukutinopathy Caused by Novel Compound Heterozygous FKTN Variants: A Diagnostic and Genetic Odyssey.

This JACC Case Reports article studied a 30-year-old Indian man with cardiac-predominant fukutinopathy to define the genetic cause of his dilated cardiomyopathy and persistent QT prolongation. Whole-exome sequencing identified compound heterozygous FKTN variants—c.1112A>G (p.Tyr371Cys, likely pathogenic) and c.1224G>T (p.Lys408Asn, VUS)—confirmed by parental Sanger sequencing, with cardiac magnetic resonance showing subepicardial late gadolinium enhancement and hyperCKemia supporting dystroglycanopathy. The significance is that genotype-directed evaluation can resolve diagnostic uncertainty in atypical, primarily cardiac presentations of FKTN-related disease.

Imayavaramban B, Kumar P, Chowdhury RR et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗

When rare meets rarer: constrictive pericarditis in Erdheim-Chester disease-a case report.

This European Heart Journal Case Reports article studied constrictive pericarditis as an exceptionally rare cardiovascular manifestation of Erdheim-Chester disease (ECD) in a 57-year-old man with multisystem involvement. Multimodality imaging showed extensive cardiovascular disease with marked pericardial thickening and echocardiographic hemodynamic features of constriction, diffuse late gadolinium pericardial enhancement on cardiac magnetic resonance, and circumferential periarterial infiltration on computed tomography. The clinical significance is that constrictive pericarditis should be considered in ECD patients with heart failure symptoms, despite its rarity.

Dimova-Mileva M, Kanchev I, Marinova E et al. · European heart journal. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗

Phenotypic overlap masking MELAS in Turner syndrome: a diagnostic challenge.

This European Heart Journal Case Reports article studied a 51-year-old woman with mosaic Turner syndrome whose phenotype masked MELAS, creating a diagnostic challenge. She had concentric left ventricular hypertrophy with mildly reduced systolic function (LVEF 45%) alongside other features such as childhood-onset hearing loss and hypothyroidism, with the case emphasizing how overlapping manifestations can delay correct MELAS recognition. The significance is that clinicians should consider mitochondrial disease (MELAS) when Turner syndrome patients develop cardiomyopathy and additional systemic features that do not fully fit the Turner phenotype.

Shinozaki T, Sumiyoshi H, Ueshima D et al. · European heart journal. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗

Left ventricular myocardial strain analysis by feature tracking cardiac magnetic resonance in patients with autoimmune rheumatic diseases: A case-control study.

This case-control study in La Clinica terapeutica evaluated left ventricular myocardial strain measured by cardiac magnetic resonance feature tracking (CMR-FT) in patients with autoimmune rheumatic diseases (ARDs) versus healthy controls. Among 30 ARD patients and 10 matched controls, the study aimed to detect subclinical myocardial dysfunction despite preserved conventional cardiac function using sensitive deformation metrics. The scientific significance is that CMR-FT strain analysis may improve early detection of cardiac involvement in ARDs, potentially guiding earlier intervention.

ElMahdy EKA, Ibrahim AS, AbdulRahim SAA et al. · La Clinica terapeutica · (2026) · View on PubMed ↗

Hemorrhagic eosinophilic pericardial effusion associated with probable sparganosis.

This case report studied a 25-year-old man with hemorrhagic eosinophilic pericardial effusion after ingesting undercooked frog meat, investigating probable sparganosis caused by Spirometra plerocercoid larvae. Despite extensive testing—including cultures, cytology, cross-sectional imaging, cardiac MRI, PET/CT, and next-generation sequencing—no alternative cause was found, and serology (ELISA) supported sparganosis. The clinical significance is that sparganosis can present with hemorrhagic eosinophilic pericarditis, and comprehensive multimodal evaluation plus serologic testing can be crucial for diagnosis.

Zhu Y, Wang D, Wu Y et al. · International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · (2026) · View on PubMed ↗ · Free PDF ↗

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Pulmonary Hypertension & Right Heart Function (strain, hemodynamics, RV failure)

Optimal Strain Combinations for Prognostic Prediction in Pulmonary Arterial Hypertension.

This Circulation: Heart Failure study evaluated prognostic value of myocardial strain combinations in patients with pulmonary arterial hypertension (PAH) recruited prospectively from June 2013 to June 2024. Using elastic net Cox regression and stepwise Cox regression with AIC, the authors found that specific combinations of left ventricular global longitudinal strain, right ventricular GLS (including right ventricular free-wall longitudinal strain), and right atrial phasic strain improved prediction of all-cause mortality and a composite endpoint. The clinical significance is that optimized multi-chamber strain models may refine risk stratification in PAH beyond single strain measures.

Guo J, Leng S, He J et al. · Circulation. Heart failure · (2026) · View on PubMed ↗

Sequential Changes in Right Ventricular Straein During the Development of Pulmonary Hypertension Assessed With Magnetic Resonance Feature Tracking: An Animal Study.

This Korean Journal of Radiology animal study investigated sequential right ventricular (RV) strain changes during pulmonary hypertension (PH) development in male Wistar rats using cardiac magnetic resonance (CMR) feature tracking. Rats received monocrotaline to induce PH and were imaged at 1, 2, 3, or 4 weeks (with vehicle-injected controls at 2 and 4 weeks), then euthanized for histology to correlate strain trajectories with vascular remodeling. The significance is that CMR feature tracking can detect early, time-dependent RV functional deterioration that parallels histologic remodeling during PH progression.

Kim NY, Im DJ, Hong YJ et al. · Korean journal of radiology · (2026) · View on PubMed ↗ · Free PDF ↗

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Ischemic Heart Disease & Revascularization (MINOCA/CMD/viability/MI injury)

Angiography-Based Index of Microcirculatory Resistance in Assessing the MVO and Infarct Size in STEMI Patients.

This Clinical Cardiology study assessed whether an angiography-based index of microcirculatory resistance (angio-IMR) can quantify microvascular obstruction (MVO) and infarct size (IS) in ST-segment elevation myocardial infarction (STEMI) patients. In 123 randomized patients receiving either 5 mg intravenous recombinant staphylokinase (r-SAK) or normal saline before PCI, angio-IMR was computed in infarct-related arteries and MVO/IS were measured by cardiac magnetic resonance imaging, with the study reporting associations between angio-IMR and CMR-defined MVO and infarct size (and evaluating thrombolysis effects on angio-IMR). Scientifically and clinically, it supports angio-IMR as a catheter-based surrogate for microvascular injury severity after thrombolysis and PCI.

Wu T, Zhang X, Li C et al. · Clinical cardiology · (2026) · View on PubMed ↗ · Free PDF ↗

Viability testing for guiding revascularization in ischemic cardiomyopathy.

This narrative review summarized evidence on myocardial viability testing to guide revascularization decisions in ischemic cardiomyopathy, focusing on how recent trials challenge the assumption that viability predicts benefit from revascularization. The key finding was that trials such as STICH and follow-up data indicate CABG improves long-term survival largely independently of viability status, in the context of modern guideline-directed medical therapy. Clinically, the review supports re-evaluating when viability testing meaningfully changes management rather than using it as a universal gatekeeper for revascularization.

Li KY, Dhingra NK, Patel R et al. · Current opinion in cardiology · (2026) · View on PubMed ↗

Spatial proximity or vector orientation? Re-evaluating ECG interpretation in anterior myocardial infarction using cardiac magnetic resonance.

This prospective study investigated whether ECG-based localization of anterior myocardial infarction (MI) using anatomical lead proximity versus vector orientation of ST-segment deviation matches CMR-defined myocardial injury. Among 105 patients scanned by CMR 3–7 days after presentation, it compared admission ECG localization categories and simplified ST-axis orientation methods against late gadolinium enhancement (LGE) injury distribution. The findings are significant for improving the accuracy of ECG interpretation in anterior MI by identifying which ECG framework better reflects true myocardial injury patterns on imaging.

Aslanger EK, Aggül B, İnan D et al. · Journal of electrocardiology · (2026) · 1 citations · View on PubMed ↗

Feasibility and Yield of a Diagnostic Protocol for Myocardial Infarction With Nonobstructive Coronary Arteries.

This prospective multicentre cohort study evaluated the feasibility and diagnostic yield of a structured MINOCA workup protocol beyond initial invasive coronary angiography (ICA) in patients with myocardial infarction with nonobstructive coronary arteries. It found that a stepwise approach using ad hoc optical coherence tomography (OCT) for culprit lesion identification (followed by additional testing as needed) enabled more definitive final diagnoses despite real-world constraints. Clinically, the protocol supports a practical, resource-aware diagnostic pathway to clarify MINOCA mechanisms after angiography.

Nishimiya K, Yosofi B, Dimitriu-Leen AC et al. · The American journal of cardiology · (2026) · View on PubMed ↗ · Free PDF ↗

Long-term prognostic value of stress cardiovascular magnetic resonance in patients with hypertension without known coronary artery disease.

This longitudinal study assessed the long-term prognostic value of vasodilator stress cardiovascular magnetic resonance (CMR) in consecutive patients with hypertension but no known coronary artery disease (CAD). Following patients referred for stress CMR (2008–2022) for major cardiovascular events (MACE: cardiovascular death or non-fatal MI), Cox regression was used to quantify prognostic associations. The significance is that stress CMR may provide risk stratification for future events in hypertensive patients without known CAD, supporting its role in screening and prevention strategies.

Houssany-Pissot S, Garot J, Duhamel S et al. · European heart journal. Cardiovascular Imaging · (2026) · 1 citations · View on PubMed ↗

Prognostic Value of Coronary Sinus Flow and Aortic Pressure Gradient Quantified by 4D Flow CMR in AMI.

This retrospective study examined whether 4D flow CMR–derived coronary sinus flow (CS Flow) and aortic pressure gradients predict outcomes in patients with acute myocardial infarction (AMI). In 103 AMI patients scanned before PCI, CS Flow (normalized to left ventricular mass) and supra-/sub-aortic valve peak pressure gradients were measured, and a composite endpoint (death, unplanned revascularization, recurrent MI, HF rehospitalization, stroke) was analyzed using stratified models after univariable screening. The clinical significance is that noninvasive 4D flow CMR hemodynamic metrics may help identify AMI patients at higher risk for adverse outcomes.

Li Y, Wang S, Li G et al. · Academic radiology · (2026) · View on PubMed ↗

Microvascular dysfunction and neurovascular signalling impairment in diabetic silent myocardial ischemia.

This article investigates the mechanisms underlying diabetic silent myocardial ischemia (DSMI) in the context of chronic hyperglycemia, focusing on coronary microvascular dysfunction and neurocardiac/neurovascular signaling impairment. It finds that oxidative stress, advanced glycation end-product (AGE) accumulation, and mitochondrial dysfunction reduce nitric oxide (NO) bioavailability and impair coronary flow reserve and capillary integrity, while diabetic peripheral/autonomic neuropathy attenuates nociceptive signaling. The significance is that DSMI pathophysiology links microvascular and neurovascular pathways, suggesting potential targets for preventing or treating this high-risk but symptom-silent condition.

Rajasekaran HK · Microvascular research · (2026) · View on PubMed ↗

Diastolic dysfunction persists 3 months after surgical revascularization in a large animal model of hibernating myocardium.

This large-animal (swine) experimental study investigated whether diastolic dysfunction persists after surgical revascularization in a model of hibernating myocardium created by chronic LAD constriction without infarction. The key finding was that diastolic dysfunction remained 3 months after coronary artery bypass grafting (CABG), indicating incomplete diastolic recovery despite revascularization. Scientifically, it supports the concept that chronic ischemia–driven diastolic impairment may not fully reverse with revascularization, informing expectations for diastolic heart failure with preserved ejection fraction.

Potel KN, Shao A, McLaughlin N et al. · The Journal of thoracic and cardiovascular surgery · (2026) · View on PubMed ↗

Early quantitative stress-perfusion cardiac magnetic resonance reveals perfusion abnormalities consistent with coronary microvascular dysfunction in MINOCA patients with otherwise normal cardiac magnetic resonance findings.

This study evaluated early quantitative stress-perfusion cardiac magnetic resonance (Q-CMR) in MINOCA patients with otherwise normal conventional CMR findings to determine the prevalence of perfusion abnormalities consistent with coronary microvascular dysfunction (CMD). The key finding was that among 46 consecutive MINOCA patients, 23 with normal conventional CMR at rest had quantitative stress-perfusion abnormalities on Q-CMR consistent with CMD, compared with age- and sex-matched healthy controls. Clinically, it supports Q-CMR as a sensitive tool to uncover microvascular dysfunction in MINOCA even when standard CMR appears normal.

Sahar R, Lenell J, Lindahl B et al. · Scientific reports · (2026) · View on PubMed ↗ · Free PDF ↗

Intravenous dexrazoxane for haemorrhagic myocardial infarction: the SHIELD-MI study.

The SHIELD-MI phase IIa study evaluated whether intravenous dexrazoxane (DXZ) given before and after primary percutaneous coronary intervention (PCI) reduces intramyocardial hemorrhage (IMH)–related injury in patients with hemorrhagic myocardial infarction after reperfused STEMI. The key finding was the feasibility of a sequential-cohort, placebo-controlled design with blinded CMR core-lab assessment, testing DXZ 250 mg at baseline and at 4, 8, and 12 hours to target iron-mediated injury from IMH. If effective, this would provide a therapy specifically aimed at IMH, potentially improving outcomes beyond standard reperfusion strategies.

Vora KP, Bhatt K, Doshi S et al. · European heart journal · (2026) · View on PubMed ↗

Stent Retriever Thrombectomy in Patients With Myocardial Infarction The Open-label, Multicenter NATURE Superiority trial.

This open-label, multicenter NATURE superiority trial studied whether adding stent-retriever thrombectomy to conventional percutaneous coronary intervention (PCI) improves outcomes in 156 patients with ST-segment elevation myocardial infarction (STEMI) and large thrombus burden (TIMI thrombus grade ≥3). The key finding reported in the abstract is that the trial was designed to test effects on infarct size by comparing stent-retriever thrombectomy plus PCI versus conventional PCI alone in this high-risk subgroup. Clinically, a demonstrated reduction in infarct size would support routine use (or non-use) of stent-retriever thrombectomy for STEMI patients with heavy intracoronary thrombus burden.

Valgimigli M, Frigoli E, Landi A et al. · Journal of the American College of Cardiology · (2026) · View on PubMed ↗

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Arrhythmias, Sudden Cardiac Death & Device/Risk Decisions (incl. myocarditis/amyloidosis)

Cardiovascular magnetic resonance-based arrhythmogenic substrate assessment improves sudden cardiac death risk stratification in heart failure with mildly reduced ejection fraction: a multicenter retrospective observational study.

This multicenter retrospective observational study evaluated cardiovascular magnetic resonance (CMR) markers—late gadolinium enhancement (LGE) and T1 mapping—for sudden cardiac death (SCD) risk prediction in 1855 patients with heart failure with mildly reduced ejection fraction (HFmrEF) across five tertiary centers. In development (n=1417) and external validation (n=438), CMR-based arrhythmogenic substrate assessment improved SCD risk stratification beyond standard clinical approaches. The findings support incorporating LGE/T1-mapping–derived substrate measures into HFmrEF SCD algorithms to better identify patients who may benefit from preventive therapies.

Wang W, Zhu R, Gao Y et al. · The Lancet regional health. Western Pacific · (2026) · View on PubMed ↗ · Free PDF ↗

Feasibility of cardiac magnetic resonance for assessing atrioventricular block in acute myocarditis.

This retrospective single-center study assessed whether cardiac magnetic resonance (CMR) can evaluate atrioventricular block (AVB) severity in acute myocarditis (AM) patients, comparing non-AVB, nonadvanced AVB, and advanced AVB groups (n=105). The key finding was that CMR functional and tissue parameters differed across AVB severity categories and were associated with adverse clinical outcomes including death, heart failure decompensation requiring readmission, and need for implantable cardioverter-defibrillator or cardiac resynchronisation therapy. Scientifically and clinically, CMR may help noninvasively characterize AVB in AM and improve risk stratification beyond clinical ECG findings.

Liao R, Qian Z, Yin F et al. · Clinical radiology · (2026) · View on PubMed ↗

Blood-nulled late gadolinium enhancement increases sensitivity for subtle basal myocardial scar in mitral valve prolapse with annular disjunction.

This case report studied a 67-year-old woman with mitral valve prolapse (MVP) and mitral annular disjunction (MAD) to determine whether blood-nulled late gadolinium enhancement (LGE) CMR improves detection of subtle basal myocardial scar. It found that conventional bright-blood LGE could obscure subendocardial fibrosis blending with the bright blood pool, whereas blood-nulled LGE better revealed the small (3-mm) posterior MAD–associated basal inferolateral scar substrate. The clinical significance is improved CMR risk stratification for arrhythmogenic MVP/MAD by increasing sensitivity for subtle fibrosis that may be missed on standard LGE.

Avakian A, Umair M · Radiology case reports · (2026) · View on PubMed ↗ · Free PDF ↗

Incremental prognostic value of cardiac magnetic resonance beyond biomarker staging in transthyretin cardiac amyloidosis.

This multicentre retrospective study evaluated whether adding cardiac magnetic resonance (CMR) parameters improves prognosis beyond National Amyloidosis Centre (NAC) serum biomarker staging in patients with transthyretin cardiac amyloidosis (ATTR-CA). In 266 ATTR-CA patients who underwent CMR (2007–2023), Cox regression analyses showed incremental prognostic value of CMR variables over the NAC stage model for time to death. The scientific significance is that CMR can refine risk stratification and potentially guide evaluation for advanced heart failure therapies and emerging disease-modifying treatments.

Chiou T, Minga I, Subashchandran V et al. · European heart journal. Cardiovascular Imaging · (2026) · 1 citations · View on PubMed ↗

Incidence and predictors of major arrhythmic events after acute myocarditis complicated by ventricular arrhythmias: A systematic review and meta-analysis.

This systematic review and meta-analysis (registered in PROSPERO) examined recurrence rates and predictors of major arrhythmic events after discharge in patients with acute myocarditis complicated by sustained ventricular arrhythmias. The key finding was that postdischarge risk of major arrhythmic events is nontrivial and that specific clinical or electrophysiologic predictors can stratify recurrence risk. Clinically, improved predictor identification can guide ICD decision-making and follow-up intensity after myocarditis-associated ventricular arrhythmias.

M’Rabet S, Kaboré EG, Rav-Acha M et al. · Heart rhythm · (2026) · View on PubMed ↗

Novel insights on ventricular arrhythmias in cardiac amyloidosis: an updated narrative review.

This narrative review examined ventricular arrhythmia mechanisms and risk stratification in patients with cardiac amyloidosis, comparing light-chain (AL) versus transthyretin (ATTR) disease patterns and the role of cardiac magnetic resonance (CMR). It found that while CMR can predict all-cause mortality, it does not reliably distinguish patients likely to experience shockable arrhythmic events from those who will die from progressive heart failure or electromechanical dissociation, weakening the evidence base for prophylactic implantable cardioverter-defibrillator (ICD) use. Clinically, the review underscores the need for better arrhythmia-specific risk markers beyond CMR mortality prediction in cardiac amyloidosis.

Butturini C, Fortunato S, Setti M et al. · Revista espanola de cardiologia (English ed.) · (2026) · View on PubMed ↗

From Scar to Stereotactic Arrhythmia Radioablation With inHEART-Guided Targeting: A Comprehensive Evaluation of Stereotactic Ablation for Ventricular Tachycardia in a Single-Center Experience.

This single-center clinical evaluation studied stereotactic arrhythmia radioablation for ventricular tachycardia using inHEART-guided targeting, including workflow development and dosimetric/clinical outcomes in the first 18 treated patients. The key finding was that the inHEART multimodality platform enabled 3D substrate segmentation and imaging integration (from contrast-enhanced cardiac CT with late-enhancement imaging, with optional CMR) to support stereotactic ablation planning and delivery. The significance is that it provides early real-world evidence for a comprehensive, imaging-integrated workflow for radioablation of ventricular tachycardia substrates.

Brun T, Mignon P, Massabeau C et al. · Practical radiation oncology · (2026) · View on PubMed ↗

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Heart Failure & Cardiomyopathy Management (including therapy de-escalation and pregnancy)

Managing pregnancy in women with pre-existing cardiomyopathies: A case series.

This 2026 case series described pregnancy management and outcomes in women with pre-existing cardiomyopathies, including dilated, hypertrophic, and arrhythmogenic cardiomyopathy, emphasizing phenotype- and genetics-driven risk. Across cases, major complications included arrhythmias, rising left ventricular outflow tract obstruction (in obstructive phenotypes), and heart failure, with management spanning biomarkers plus pharmacologic and device strategies during pregnancy, delivery, and postpartum. Clinically, the report highlights the need for pre-conception risk profiling and tailored monitoring/therapy in cardiomyopathy pregnancies to reduce maternal and fetal complications.

Bruce C, Montanaro C, Wander G et al. · Case reports in women’s health · (2026) · View on PubMed ↗ · Free PDF ↗

Lower- Versus Conventional-Sodium Dialysate and Left Ventricular Mass in Patients Receiving Hemodialysis: Causal Analyses of a Randomized Clinical Trial.

This causal analysis used a randomized clinical trial framework to investigate why allocation to lower dialysate sodium ([Na+]) reduced interdialytic weight gain and BNP but did not reduce left ventricular mass index (LVMI) measured by cardiac magnetic resonance in home/self-care hemodialysis patients. The analysis modeled causal pathways between dialysate [Na+] allocation, intermediate physiologic variables, and LVMI to explain the unexpected lack of LVMI reduction. The results help refine mechanistic understanding of how dialysate sodium influences cardiac remodeling and may guide future interventions targeting LV hypertrophy in hemodialysis.

Marshall MR, Vandal AC, Chan CT et al. · Kidney medicine · (2026) · View on PubMed ↗ · Free PDF ↗

Precision-guided heart failure interventions: The expanding role of advanced cardiac imaging and artificial intelligence.

This article reviewed how precision-guided heart failure interventions increasingly rely on advanced cardiac imaging and artificial intelligence to tailor care across diverse heart failure phenotypes. The key finding was that integrating imaging/AI into domains of anatomy, myocardial substrate, and physiology supports more targeted use of transcatheter valve therapies, cardiac resynchronization/pacing, complex coronary interventions, invasive hemodynamics, implantable pressure sensors, and advanced heart failure therapies. Scientifically and clinically, this framework supports more individualized diagnosis and treatment selection to improve outcomes in heart failure.

Albulushi A, Al-Farhan H · American heart journal plus : cardiology research and practice · (2026) · View on PubMed ↗ · Free PDF ↗

The Relationship Between Physical Activity and Left Ventricular Remodeling in Childhood Cancer Survivors Treated With Anthracyclines: A Cross-Sectional Study.

This cross-sectional study examined the relationship between moderate-to-vigorous physical activity (MVPA) measured by accelerometry and cardiac remodeling measured by cardiovascular magnetic resonance in childhood cancer survivors treated with anthracyclines (≥2-year survivors). The key finding was that MVPA was associated with differences in CMR-derived LV remodeling parameters, including indexed end-diastolic LV mass (LVMi), LV end-diastolic volume (LVEDVi), mass:volume ratio, and LV ejection fraction (LVEF). These results suggest that physical activity may modulate early anthracycline-related cardiotoxic remodeling, informing survivorship risk reduction strategies.

Narayan HK, Chen S, Wong FL et al. · Pediatric blood & cancer · (2026) · View on PubMed ↗

Safety of withdrawal of pharmacological treatment after recovery from HER2 therapy-related cardiac dysfunction: the HER-SAFE trial.

The HER-SAFE trial studied whether heart failure therapy (HFT) can be safely withdrawn in breast cancer survivors who had recovered from anti-HER2 therapy–related cardiac dysfunction (CTRCD), enrolling patients with asymptomatic status, left ventricular ejection fraction (LVEF) ≥50%, and normalized biomarkers. In this open-label, multicentre randomized controlled trial, participants were assigned to HFT withdrawal versus continuation after prior mild, moderate, or severe CTRCD, with the trial designed to test safety of stopping pharmacologic therapy in this recovered population. If withdrawal is shown to be safe, it could reduce long-term medication burden in HER2-treated breast cancer survivors without compromising cardiac recovery.

Dowsing B, Dehbi HM, Andres MS et al. · European heart journal · (2026) · View on PubMed ↗ · Free PDF ↗

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Hypertrophic Cardiomyopathy (HCM) Imaging, Risk, and Genetics

[Ventricular hypertrophy and pre-excitation: a diagnostic clue to PRKAG2-related cardiomyopathy].

This case report described a 44-year-old man with ventricular hypertrophy, pre-excitation, and supraventricular arrhythmias consistent with PRKAG2-related cardiomyopathy, a metabolic phenocopy of hypertrophic cardiomyopathy. Cardiac magnetic resonance showed asymmetric hypertrophy with extensive late gadolinium enhancement and early adverse remodeling, suggesting an overlap phenotype between hypertrophic cardiomyopathy and arrhythmogenic left ventricular cardiomyopathy, and genetic testing confirmed a heterozygous PRKAG2 variant. The case underscores CMR features and PRKAG2 genetic testing as diagnostic tools to avoid misclassification and to guide prevention decisions such as primary-prevention implantable cardioverter-defibrillator placement.

Quadrini F, Rodio D, Maddaluna P et al. · Giornale italiano di cardiologia (2006) · (2026) · View on PubMed ↗

Enhanced risk stratification in hypertrophic cardiomyopathy through the integration of extracellular volume fraction on cardiovascular magnetic resonance.

This cohort study assessed whether CMR-derived extracellular volume fraction (ECV), a marker of diffuse interstitial fibrosis, adds prognostic value beyond late gadolinium enhancement (LGE) in hypertrophic cardiomyopathy (HCM) patients (n=990) followed for a median of 3.2 years. The key finding was that integrating global ECV improved risk stratification for HCM-related events—a composite of sudden cardiac death events, heart failure events, and HCM-related death—beyond LGE alone. Clinically, this supports using ECV to better identify higher-risk HCM patients and refine prognostic counseling and management.

Lee HJ, Gwak SY, Lee S et al. · European heart journal. Cardiovascular Imaging · (2026) · 1 citations · View on PubMed ↗

Left atrial reservoir strain for predicting progression to end-stage in hypertrophic cardiomyopathy.

This longitudinal study analyzed 925 patients with hypertrophic cardiomyopathy (HCM) to determine whether left atrial reservoir strain predicts progression to end-stage HCM, with a CMR subcohort of 491 patients. The key finding is that left atrial reservoir strain provides prognostic information for progression to end-stage disease (LVEF <50% without reversible causes) over a median follow-up of 6.5 years. Clinically, it supports using left atrial strain as an echocardiographic risk marker to identify patients likely to deteriorate toward end-stage HCM.

Kwak S, Jeong MH, Park CS et al. · European heart journal. Cardiovascular Imaging · (2026) · 1 citations · View on PubMed ↗

Prognostic Value of MRI-Based Left Ventricular Trabecular Complexity for Sudden Cardiac Death in Hypertrophic Cardiomyopathy.

This prospective study evaluated 835 hypertrophic cardiomyopathy (HCM) patients using cardiac MRI to quantify left ventricular myocardial trabecular complexity via fractal dimension (FD) from 3T steady-state free precession (SSFP) cine imaging. Higher LV trabecular complexity (FD) was validated as a prognostic marker for sudden cardiac death risk and was analyzed in relation to sarcomere gene variants. The scientific significance is that MRI-based trabecular complexity could improve risk stratification for SCD in HCM alongside genetic information.

Zhang J, Yu M, Pu L et al. · Journal of magnetic resonance imaging : JMRI · (2026) · 1 citations · View on PubMed ↗ · Free PDF ↗

Unmasking subclinical cardiomyopathy: The role of cardiopulmonary exercise testing when screening genotype-positive phenotype negative relatives.

This single-centre case series studied genotype-positive, phenotype-negative relatives from families with likely/definite pathogenic cardiomyopathy variants to determine whether cardiopulmonary exercise testing (CPET) can unmask subclinical cardiomyopathy beyond standard screening. The key finding was that CPET provided additional detection of subclinical disease in gene-positive phenotype-negative relatives when conventional ECG/echo/Holter/cardiac MRI screening was unremarkable. Clinically, CPET may improve cascade-testing risk stratification and guide earlier intervention in at-risk relatives.

Abela M, Scicluna J, Debattista J et al. · International journal of cardiology · (2026) · View on PubMed ↗

Incremental prognostic value of late gadolinium enhancement in hypertrophic cardiomyopathy in a large contemporary cohort.

This large contemporary cohort study assessed the incremental prognostic value of late gadolinium enhancement (LGE) in hypertrophic cardiomyopathy (HCM) using cardiac MRI in 3,035 patients followed for a median of 8.8 years. The key finding was that higher %LGE was independently associated with the primary endpoint (hazard ratio ~1.05 per 1% increase; p<0.001), including cardiovascular death and appropriate ICD discharges. This is significant because quantifying LGE can refine risk stratification and guide management decisions such as ICD consideration in HCM.

Keen SK, Shah S, Sheashaa H et al. · Cardiovascular research · (2026) · View on PubMed ↗

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Risk Stratification & Prognosis Using CMR Biomarkers (LGE/T1/ECV/Strain/Indices)

[Interarterial anomalous right coronary artery in a competitive athlete: case report].

This case report evaluated a 37-year-old competitive endurance athlete found on pre-participation screening to have an interarterial anomalous right coronary artery originating from the left sinus of Valsalva with an intramural course. Coronary computed tomography angiography identified high-risk anatomical features associated with exercise-related ischemia and sudden cardiac death risk. The report emphasizes that dynamic risk in athletes depends on both coronary anatomy and exertional hemodynamic stress, supporting careful imaging-based risk assessment in sports clearance.

Lodi E, Tardini L, Poli ML et al. · Giornale italiano di cardiologia (2006) · (2026) · View on PubMed ↗

Cardiac volumes, function, and arterial stiffness five years after severe preeclampsia: A comparison with sedentary and active controls.

This study compared cardiovascular magnetic resonance (CMR) measures of cardiac volumes, function, and arterial stiffness five years after severe preeclampsia versus normotensive pregnancies in 30 women (10 lifestyle-matched and 10 physically active controls plus 10 with severe preeclampsia). The key finding was that women with prior severe preeclampsia showed measurable long-term cardiovascular alterations on CMR relative to controls, indicating persistent vascular and cardiac impact. Scientifically and clinically, it supports CMR-based phenotyping as a way to identify women at elevated future cardiovascular risk after severe preeclampsia.

Edvinsson C, Steding-Ehrenborg K, Venkateshvaran A et al. · Clinical physiology and functional imaging · (2026) · View on PubMed ↗ · Free PDF ↗

Integrated left ventricular mass and left atrial function for prediction of cardiovascular outcomes: the Multi-Ethnic Study of Atherosclerosis.

This study evaluated whether a cardiac magnetic resonance (CMR)-derived left ventricular (LV) mass-to-left atrial (LA) strain ratio predicts cardiovascular outcomes in participants from the Multi-Ethnic Study of Atherosclerosis who underwent CMR at exams 1 (2000–2002) and 5 (2010–2012). The key finding was that LV mass-to-LA strain imbalance, reflecting early atrioventricular mechanical uncoupling, identified higher risk for subsequent cardiovascular events beyond considering LV mass or LA strain alone. Clinically, this CMR-derived ratio could improve early risk stratification for atrioventricular uncoupling and atrial myopathy before overt structural disease.

Salameh E, Hoballah M, Ebrahimihoor E et al. · American journal of physiology. Heart and circulatory physiology · (2026) · View on PubMed ↗

Noninvasive Diagnosis of Heart Failure With Preserved Ejection Fraction Using the Left Atrioventricular Coupling Index.

This retrospective multicenter study compared three imaging modalities for calculating the left atrioventricular coupling index (LACI)—defined as left atrial minimal volume divided by left ventricular end-diastolic volume—as a noninvasive surrogate for left ventricular diastolic dysfunction in 1,680 patients undergoing evaluation for heart failure with preserved ejection fraction (HFpEF). The key finding was the diagnostic performance of LACI-based approaches for identifying HFpEF compared with the invasive reference standard of right heart catheterization. This is clinically important because it could reduce reliance on invasive hemodynamic testing by enabling more accessible HFpEF diagnosis.

Janssen-Telders C, Ābele J, Meijboom LJ et al. · Journal of the American Heart Association · (2026) · View on PubMed ↗ · Free PDF ↗

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Cardiac Imaging AI Bias, Representation & Clinical Implementation

A cross-sectional online survey evaluating how anaesthesiologists view cardiovascular magnetic resonance imaging reports as a tool for perioperative risk evaluation.

This cross-sectional online survey assessed how anaesthesiologists perceive and use cardiovascular magnetic resonance (CMR) reports for perioperative risk evaluation. The key finding was that incorporation of pre-existing CMR findings into perioperative decision-making varied, reflecting differences in perceived utility and understanding of CMR report content. The study highlights a practical barrier to translating CMR into perioperative care and supports improving report standardization and clinician education.

Fischer K, Harms R, Fini JN et al. · BJA open · (2026) · View on PubMed ↗ · Free PDF ↗

Toward Robust and Harmonious Adaptation for Cross-modal Retrieval.

This work addressed robust cross-modal retrieval (CMR) under query shift in real-world settings where the full target-domain query set is not available for general-to-customized adaptation. The key finding was that query shift introduces online and distributional changes that degrade existing general-to-customized cross-modal retrieval methods, motivating a more robust and harmonious adaptation strategy. Clinically, this supports more reliable retrieval of relevant data across modalities (e.g., imaging and text) for downstream medical AI tasks when deployment conditions differ from training.

Li H, Liu Z, Yang M et al. · IEEE transactions on pattern analysis and machine intelligence · (2026) · View on PubMed ↗ · Free PDF ↗

Echo Chambers: Bias and Representation in Cardiac Imaging Datasets for Artificial Intelligence.

This review examined bias and representation in publicly available cardiac imaging datasets used for artificial intelligence across echocardiography, cardiac MRI, and cardiac CT. The key finding was that ~80% of datasets originate from high-income countries, demographic information is reported in fewer than two-thirds, and there are major gaps in racial/ethnic outcome reporting and model performance across groups. This is significant because it highlights inequities in training data that can lead to biased AI performance and underscores the need for more diverse, outcome-linked datasets.

Gorijavolu R, Jaiswal N, Pratap JS et al. · Current cardiology reports · (2026) · View on PubMed ↗

Artificial Intelligence-enhanced cardiac MRI reporting: expert validation and patient-centered outcomes.

In a prospective study of 75 consecutive outpatients undergoing cardiac MRI at two Italian tertiary centers, the authors tested whether ChatGPT-4o could generate simplified, patient-facing explanations and tailored clinical recommendations from physician-dictated CMR reports. The key finding was that ChatGPT-4o improved accessibility of CMR information while maintaining accuracy and safety as assessed by expert validation and patient-centered outcomes. This is clinically significant because it may help patients understand CMR findings and support non-imaging clinicians with clearer, actionable summaries.

Frontera A, Kotinas A, Musella A et al. · The international journal of cardiovascular imaging · (2026) · View on PubMed ↗

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Cardiac MRI AI & Deep Learning (Segmentation, Reconstruction, Motion, Radiomics)

Spatial phenotyping of epicardial adipose tissue from cardiac MRI.

This study developed a deep learning framework to spatially phenotype epicardial adipose tissue (EAT) distribution across the heart using cardiac MRI, segmenting the four chambers and EAT with an asymmetric multi-modal CNN-Transformer. The key finding was that combining automated cardiac MRI segmentation with spatial statistical modeling enabled quantitative, chamber-resolved characterization of EAT distribution rather than relying on limited or non-spatially resolved approaches. Scientifically, this provides a tool to better link EAT spatial patterns to cardiovascular disease risk and mechanisms.

Feng F, Long T, Hasaballa AI et al. · Medical image analysis · (2026) · View on PubMed ↗ · Free PDF ↗

Deformable image registration for self-supervised cardiac phase detection in cardiac magnetic resonance images of patients with various diseases.

This study proposed a self-supervised deep learning approach using deformable image registration to detect cardiac phase keyframes in short-axis (SAX) and four-chamber (4CH) cine CMR across patients with various diseases. The key finding was that the method could automatically identify five keyframes (SAX) and four keyframes (4CH) by learning motion descriptors from registration-derived temporal information, addressing limitations of methods that only infer end-systole and end-diastole from LV volume curves. Scientifically, improved keyframe detection can enable more robust automated CMR analysis and sub-phase assessment for diverse cardiac conditions.

Mueller SK, Koehler S, Kiekenap J et al. · Medical image analysis · (2026) · View on PubMed ↗ · Free PDF ↗

ContiMorph: An unsupervised learning framework for cardiac motion tracking with time-continuous diffeomorphism.

This paper studied ContiMorph, an unsupervised learning framework for cardiac motion tracking in cardiac image sequences, aiming to overcome limitations of scaling-and-squaring (SS)–based discrete integration that reduce use of temporal continuity. It found that combining a frame-aware U-Net with a time-embedded transformer enables learning time-continuous intra-frame motion fields, improving tracking accuracy relative to approaches constrained by SS integration. Scientifically, the method advances temporally consistent cardiac motion estimation, which can benefit downstream functional assessment and disease diagnosis.

Jiang M, Ruan X, Zheng L et al. · Medical image analysis · (2026) · View on PubMed ↗

CardioMorphNet: Cardiac motion prediction using a shape-guided Bayesian recurrent deep network.

This study developed and tested CardioMorphNet, a shape-guided Bayesian recurrent deep network for 3D cardiac motion prediction using short-axis (SAX) cine cardiac MRI. By using a recurrent variational autoencoder to model spatiotemporal dependencies and incorporating posterior models for bi-ventricular segmentation, the method targets improved deformable registration that emphasizes cardiac anatomy rather than purely intensity-based similarity losses. Scientifically, it advances AI-based CMR motion estimation that could improve downstream assessment of cardiac function and disease detection.

Movahed RA, Rezaee A, Zakeri A et al. · Medical image analysis · (2026) · View on PubMed ↗ · Free PDF ↗

Stratification of children with myocarditis using radiomics signatures in LGE cardiovascular MRI.

This study investigated whether radiomics signatures derived from late gadolinium enhancement (LGE) cardiovascular MRI can stratify pediatric myocarditis patients. Using radiomic feature extraction from LGE texture and location (with attention to resampling variability via a digital phantom and methods such as non-negative matrix factorization), it aimed to identify quantitative signatures associated with different clinical courses/outcomes. The clinical significance is that LGE radiomics could move pediatric myocarditis assessment beyond qualitative interpretation toward data-driven risk stratification.

Laube AP, Huellebrand M, Ter-Minassian L et al. · Computer methods and programs in biomedicine · (2026) · View on PubMed ↗ · Free PDF ↗

CardioRadNet: Cardiac mass diagnosis through integrated segmentation and radiomic analysis.

This study developed CardioRadNet, an integrated deep learning segmentation plus radiomics classification framework to diagnose cardiac masses using contrast-free T1-weighted cardiac MRI. In 127 patients with pathologically confirmed cardiac masses (62 malignant, 65 benign), the model aimed to differentiate benign versus malignant lesions without relying on manual delineation. The clinical significance is that automated segmentation and radiomics on routine contrast-free T1 CMR could improve diagnostic workflow and triage for rare cardiac masses.

Ferretti M, Pagliaccia M, Baggiano A et al. · Computer methods and programs in biomedicine · (2026) · View on PubMed ↗ · Free PDF ↗

EFFNet: Efficient feature fusion network for left ventricular hypertrophy identification based on 12-lead electrocardiogram signals.

This study developed and tested EFFNet, an efficient feature fusion deep learning model for left ventricular hypertrophy (LVH) identification using 12-lead electrocardiogram (ECG) signals. The key finding was that EFFNet combines CNN-derived morphological features with algorithm-derived amplitude features via a mixture-of-experts module to improve LVH classification performance using 5-fold cross-validation. Clinically, it suggests a more sensitive ECG-based approach for LVH detection than conventional criteria, potentially enabling earlier identification of LVH-related cardiovascular risk.

Yu R, Jia L, Pu Y et al. · Heart rhythm · (2026) · View on PubMed ↗

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Valvular Heart Disease & Transcatheter Repair Planning/Selection (MR/TPVR/M-TEER)

An integrative approach to patient selection for mitral transcatheter edge-to-edge repair in secondary mitral regurgitation.

This review studied how to select patients with secondary mitral regurgitation (SMR) for mitral transcatheter edge-to-edge repair (M-TEER) by integrating randomized trial evidence (notably MITRA-FR and COAPT) with proportionality concepts and multimodality imaging. It found that divergent trial outcomes are largely explained by differences in echocardiographic selection and left-ventricular remodeling, implying SMR severity should be interpreted relative to ventricular size and regurgitant context. Scientifically and clinically, the proposed structured selection framework aims to better identify SMR patients most likely to benefit from M-TEER despite heterogeneity in disease mechanisms.

Brusosa M, Flores-Umanzor E, Horlick E · Current opinion in cardiology · (2026) · View on PubMed ↗

One Anatomy, Multiple Valve Choices: Interobserver Agreement in Selecting Transcatheter Pulmonary Valve.

This study evaluated interobserver agreement among six experienced clinicians selecting transcatheter pulmonary valve (TPVR) device type, size, and position using 3D patient-specific anatomies reconstructed from cardiac magnetic resonance images. Using Cohens’ kappa–based agreement metrics (as described in the methods), it found measurable variability in TPVR planning decisions across observers for valve type (self-expanding vs balloon-expandable vs surgical approach), size, and positioning. The results are significant for improving standardization of TPVR planning and for designing more reproducible, anatomy-based device selection workflows.

Pérez-Cualtán CE, Cabrales J, Garay F et al. · Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions · (2026) · View on PubMed ↗ · Free PDF ↗

Advances in artificial intelligence for the evaluation of mitral regurgitation.

This review summarizes advances in artificial intelligence (AI) for evaluating mitral regurgitation (MR) across the diagnostic pathway, including upstream screening and advanced multimodality imaging. It finds that AI approaches such as digital stethoscopes and deep learning–based electrocardiographic models can enable scalable detection and risk stratification, but currently function more as enrichment tools than standalone diagnostics. The clinical significance is that it maps where AI is ready for integration versus where further validation is needed to improve MR assessment and reduce interobserver variability.

Sanchez AA, Sadeghpour A, Asch FM · Current opinion in cardiology · (2026) · View on PubMed ↗

Mitral Regurgitation Assessment Using a Novel Automated Three-Dimensional Color-Flow Quantification: Comparison with Two-Dimensional Proximal Isovelocity Surface Area and Cardiac Magnetic Resonance.

This retrospective study evaluated 185 patients with mitral regurgitation (MR) who underwent transesophageal echocardiography (TEE), comparing a novel automated three-dimensional color-flow quantification tool (3D Auto CFQ) against two-dimensional proximal isovelocity surface area (2D PISA) and cardiac MRI. The key finding was the feasibility and performance of 3D Auto CFQ for quantifying MR severity and regurgitant volume (RVol) relative to established 2D and CMR reference methods. The clinical significance is that automated 3D TEE color-flow quantification may reduce geometric assumptions and improve MR quantification accuracy compared with conventional 2D approaches.

Kim K, Lee SH, Lee HJ et al. · Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography · (2026) · View on PubMed ↗

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Congenital Heart Disease & Fontan/Cyanotic Physiology (including hemodynamics and imaging)

Pathophysiologic Consequences of Early Coarctation Stenting in a Longitudinal Porcine Model.

This study used a longitudinal porcine model of coarctation of the aorta (COA) to examine pathophysiologic consequences of early COA stenting with serial dilation to adult aortic diameters in swine (sham, COA controls, and COA stents). The key finding is that early stent implantation with staged dilation produces measurable longitudinal cardiovascular changes compared with COA controls, indicating that early intervention alters downstream vascular and cardiovascular physiology. Scientifically, it supports preclinical evidence that timing and technique of COA stenting can have mid-term consequences relevant to optimizing pediatric COA management.

Gober LM, Stellon MA, Culver MA et al. · Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions · (2026) · View on PubMed ↗ · Free PDF ↗

Impact of Systemic-to-Pulmonary Artery Shunt Embolization on Right Heart Hemodynamics in Patients with Bronchiectasis.

This study evaluated bronchiectasis patients with systemic-to-pulmonary artery shunts (SPS) to determine whether right heart hemodynamics improve after SPS embolization, using right heart catheterization and cardiac MR in selected patients. After embolization, key hemodynamic measures (including stroke volume, cardiac index/output, pulmonary artery pressures, and shunt oxygen saturation) were assessed before and within 24–48 hours post-procedure, showing the study’s central effect of embolization on right-sided circulation. Scientifically, it supports using invasive hemodynamic endpoints (and CMR when feasible) to quantify early physiologic response to SPS embolization in bronchiectasis.

Wu H, Jiang F, Guo L et al. · Journal of vascular and interventional radiology : JVIR · (2026) · View on PubMed ↗

Multicenter comparison of hybrid and Norwood procedures in patients with Fontan circulation.

This multicenter registry analysis compared hybrid stage 1 palliation (HS1P) versus the Norwood procedure in patients with Fontan circulation using the Fontan Outcomes Registry with Clinical Examinations and propensity score matching. The study found differences in the composite outcome and related cardiac magnetic resonance variables between strategies, with additional subgroup comparisons by shunt type (Sano vs Blalock–Taussig). These data inform surgical decision-making for initial palliation pathways that affect downstream Fontan outcomes.

Kobayashi K, Schiff M, Seese L et al. · The Journal of thoracic and cardiovascular surgery · (2026) · View on PubMed ↗ · Free PDF ↗

5D Flow MRI Reveals Respiration-Driven Changes in Blood Flow Energetics in Congenital Heart Disease.

This 5D flow MRI study assessed respiration-driven changes in blood flow energetics in right-sided congenital heart disease, comparing 14 Fontan patients, 10 intracardiac shunt patients, and 9 controls. The key finding was that respiratory state significantly altered kinetic energy and viscous energy loss metrics, revealing flow inefficiency patterns not captured by standard 4D flow approaches. Scientifically and clinically, 5D flow MRI may enable more accurate hemodynamic monitoring and optimization of management in congenital heart disease where breathing affects pulmonary flow.

Nallamothu T, Weiss EK, Baraboo J et al. · Magnetic resonance in medicine · (2026) · View on PubMed ↗ · Free PDF ↗

Sport Type Alone Does Not Reliably Predict Distinct Cardiac Phenotypes in Athletes.

This study tested whether sport-type classification frameworks from ESC and AHA/ACC guidelines predict cardiac remodeling phenotypes measured by cardiac MRI in 1,024 elite athletes and controls. The key finding was that sport type alone did not reliably predict distinct CMR-determined remodeling phenotypes when CMR metrics were converted to sex-specific z-scores (remodeling defined as z≥1.645). This is significant for sports cardiology because it suggests that guideline sport categories may be insufficient for phenotype prediction, emphasizing the need for direct imaging-based assessment.

van Diepen MA, Prakken NHJ, van der Zwaard S et al. · European journal of preventive cardiology · (2026) · View on PubMed ↗ · Free PDF ↗

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Cardiac MRI Quantification & Imaging Protocol Optimization

Intraoperative Cardiac Events During Pediatric Cardiac Magnetic Resonance Imaging Under Anesthesia: A Retrospective Cohort Study.

This retrospective cohort study evaluated intraoperative cardiac events during pediatric cardiac magnetic resonance imaging (MRI) under anesthesia in children ≤18 years with congenital heart disease (CHD). It reports the incidence and predictors of intraoperative cardiovascular instability using a recently proposed composite framework for perioperative instability. Clinically, defining event rates and risk factors in this non-surgical but physiologically vulnerable setting can inform anesthesia monitoring and risk stratification for pediatric cardiac MRI.

Wingert T, Liang J, Feldman K et al. · Paediatric anaesthesia · (2026) · View on PubMed ↗ · Free PDF ↗

Free-Breathing Dynamic, Regularized, Adaptive Cluster Optimization (DRACO) Cine Cardiac MRI in Atrial Fibrillation.

This prospective study evaluated a tailored free-breathing version of DRACO (Dynamic Regularized Adaptive Cluster Optimization) cine cardiac MRI in atrial fibrillation (AF), comparing performance in 20 AF patients versus 10 sinus rhythm controls at 3.0T using bSSFP cine with ECG-gated segmented acquisition. The key finding is that DRACO can generate high-quality, quantifiable cine images under free-breathing conditions in AF while simultaneously addressing cardiac and respiratory motion. The scientific and clinical significance is improved feasibility of cine cardiac MRI for AF patients who cannot reliably perform breath-holds, potentially enabling more consistent assessment of cardiac function in routine practice.

Ming Z, Pogosyan A, Dong X et al. · Journal of magnetic resonance imaging : JMRI · (2026) · 1 citations · View on PubMed ↗ · Free PDF ↗

Artificial intelligence for right ventricular assessment: current evidence and future directions.

This review studied the current evidence for artificial intelligence (AI) methods that automate right ventricular (RV) structural and functional assessment across echocardiography, cardiac MRI (CMR), and computed tomography (CT). It found that AI-driven automated RV segmentation and chamber quantification can achieve accuracy approaching interobserver variability, addressing interpreter variability and technical difficulty. Clinically, this supports AI as a pathway to more reproducible RV measurements for risk stratification in pulmonary hypertension, valvular disease, and congenital heart disease.

Tan X, Fowler J, Li M et al. · Current opinion in cardiology · (2026) · 1 citations · View on PubMed ↗

Optimized Reduced Field of View and Fat Suppression Methods for Interleaved Multislice In Vivo Cardiac Diffusion Tensor Imaging.

This MRI method optimization study developed and tested reduced field-of-view (FOV) and fat-suppression strategies for interleaved multislice in vivo cardiac diffusion tensor imaging (cDTI). Using two-slice motion-compensated spin-echo data from 20 healthy volunteers, the authors compared reduced phase-encode FOV pulse schemes (including 2DRF and flip-back approaches) to improve signal-to-noise ratio while minimizing artifacts. The work supports more robust, clinically feasible cDTI acquisition by reducing scan-related artifacts and improving image quality.

Luo Y, Ferreira PF, Wen K et al. · Magnetic resonance in medicine · (2026) · 1 citations · View on PubMed ↗ · Free PDF ↗

Evaluation of Third-Order Motion-Compensated Cardiac Diffusion Tensor Imaging Across Cardiac Phases Using an Ultra-High-Performance Clinical Scanner.

This study evaluated a third-order motion-compensated cardiac diffusion tensor imaging sequence (M3-MCSE) across cardiac phases on a clinical 3T scanner with ultra-high-performance gradients, comparing it with STEAM and second-order MCSE (M2-MCSE). In 20 healthy subjects, diffusion tensor imaging metrics and image quality were compared at peak systole and diastasis, and additional subjects were scanned at multiple diastolic trigger delays to quantify motion-induced signal loss. The results indicate whether higher-order motion compensation improves cDTI reliability across the cardiac cycle, advancing diffusion imaging for cardiac microstructure assessment.

Wen K, Ferreira PF, Di Biase Oemick A et al. · Magnetic resonance in medicine · (2026) · View on PubMed ↗ · Free PDF ↗

Agreement between single and multiple ROI strategies for hepatic T1 and ECV mapping in tetralogy of Fallot and Fontan circulation.

This prospective agreement study assessed hepatic native T1 and extracellular volume (ECV) mapping in patients with repaired tetralogy of Fallot (TOF) and Fontan circulation, comparing a single wide region-of-interest (ROI) strategy versus multiple small ROIs on cardiac MRI. The key finding was the level of agreement between the two ROI approaches for quantifying hepatic native T1 and ECV in this specific congenital heart disease population. The results are significant because they help standardize hepatic CMR quantification methods when evaluating congestion/fibrosis-related biomarkers in repaired TOF and Fontan physiology.

Innocenzi AM, Fernandes FP, Secco JCP et al. · Abdominal radiology (New York) · (2026) · View on PubMed ↗ · Free PDF ↗

A scoping review of photon-counting detector computed tomography in cardiovascular imaging.

This scoping review summarized evidence on photon-counting detector CT (PCD-CT) for cardiovascular imaging across 59 included studies published between January 2021 and September 2025. The key finding was that, despite heterogeneity in protocols and endpoints, PCD-CT enables high-resolution, multi-energy cardiovascular imaging and shows diagnostic performance signals in domains such as coronary, myocardial, structural/valvular, pulmonary-cardiopulmonary function, and aortic/peripheral territories. Scientifically, it maps current capabilities and gaps, guiding future comparative studies and protocol standardization for PCD-CT in cardiovascular care.

Alis D, Önal MO, Orman M et al. · Diagnostic and interventional radiology (Ankara, Turkey) · (2026) · 1 citations · View on PubMed ↗ · Free PDF ↗

Accelerated Cardiac MRI Using Deep Learning Cine Imaging: Validation in Pediatric Patients both with and without Congenital Heart Disease.

This prospective validation study assessed accelerated cardiac MRI using deep learning cine reconstruction in pediatric patients with and without congenital heart disease (CHD), comparing DL-accelerated cine imaging against conventional breath-held 2D bSSFP cine. The key finding was that DL-based cine imaging at multiple acceleration levels (with breath-held acquisitions over 3-RR intervals) was validated in pediatric cohorts including CHD patients, aiming to preserve diagnostic accuracy while reducing acquisition burden. The significance is that deep learning cine acceleration could improve feasibility and image quality in children who struggle with repeated breath holds during cardiac MRI.

Kochav J, Ma J, Jambawalikar S et al. · Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · (2026) · View on PubMed ↗ · Free PDF ↗

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Thrombus, Embolism & Antithrombotic-Relevant Imaging (LVT and related)

Meta-analysis of imaging techniques for the diagnosis of left ventricular thrombus following acute myocardial infarction.

This meta-analysis evaluated the diagnostic performance of common imaging modalities for detecting left ventricular thrombus (LVT) after acute myocardial infarction (AMI) by searching Medline, Embase, and the Cochrane Library through May 2025. The key finding was that multiple imaging techniques have variable accuracy for LVT diagnosis in post-AMI patients, with comparative performance summarized across 14 included studies. Clinically, optimizing the choice of imaging modality can improve early LVT detection and guide appropriate antithrombotic therapy to reduce embolic risk.

Low CJ, Leow AS, Teo YN et al. · Journal of thrombosis and thrombolysis · (2026) · View on PubMed ↗

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Generated automatically on September 03, 2026. Covers PubMed articles published August 27, 2026 – September 03, 2026. Summaries are AI-generated; always consult the original publication for clinical or research decisions.