What's New in Cardiac MRI? — September 04, 2026

AI-summarised digest of 92 PubMed articles on Cardiac MRI published in the last 7 days.

Jump to category

Fetal Cardiac MRI Standardization Hypertrophic Obstructive Cardiomyopathy (HOCM) & Myosin Inhibitors Cardiovascular Magnetic Resonance (CMR) Prognosis & Risk Stratification Myocardial Scar, Fibrosis & Tissue Characterization (CMR/CT/AI) Reperfusion Injury & STEMI Complications Cardiac Tumors & Masses (Imaging/Diagnosis) Takotsubo Syndrome & Stress Cardiomyopathy Arrhythmias, Sudden Cardiac Death (SCD) & Risk Markers Cardiac Imaging AI/Deep Learning & Automated Quantification Systemic Diseases with Cardiac Involvement (SSc, Sarcoid, etc.) Congenital/Genetic Cardiomyopathies & Channelopathies Pulmonary Hypertension & Right Heart Function Pericardial Disease (Constrictive/Effusion/Pericarditis) HIV Care Delivery & Adherence Support Pregnancy-Related Cardiac Care Heart Failure & Ventricular Remodeling (including Strain/ECV) Cardiovascular Imaging Cost-Effectiveness & Policy Other (Non-cardiac) Biomarkers & Mechanistic Studies Cardiac Imaging in Pediatrics & Congenital Heart Disease Valvular Heart Disease & Transcatheter Planning (MR/TPVR) Myocarditis & Inflammatory Cardiomyopathy Coronary Disease, Microvascular Ischemia & MINOCA Pathways Cardiac Imaging Methods & Acquisition Optimization Thromboembolism/Embolization & Vascular Shunts Exercise/Activity & Cardiovascular Outcomes Trauma & Hypothermia Outcomes

What’s New in Cardiac MRI?

September 04, 2026 · 92 articles · 26 research themes · covering August 28, 2026 – September 04, 2026

Overview

Across this week’s set of studies, a dominant theme is the expanding role of advanced cardiac imaging—especially CMR and CT—both for diagnosis and for risk stratification. Multiple cohorts and registries show that tissue characterization (e.g., LGE, T1/ECV, stress CMR, and scar/hemorrhage metrics) improves prognostic prediction beyond conventional clinical assessment, including in challenging populations such as younger patients with suspected CAD, HF with mildly reduced EF, and HCM. Several works also emphasize “accessible alternatives” to more specialized techniques (e.g., conventional T2-weighted IMH instead of T2* mapping; CT-based scar detection using CCTA/CAC with CMR as reference), reflecting a practical push toward scalable imaging biomarkers.

A second major theme is the use of imaging to refine clinical decision-making in specific high-risk cardiac syndromes. Studies and reviews address myocarditis (including post-discharge ventricular arrhythmia recurrence and CMR-based stratification of AV block severity), reperfusion injury after STEMI (IMH and catheter-based microvascular obstruction assessment validated against CMR), and arrhythmia/SCD risk in inherited or structural disease (trabecular complexity in HCM, EMW negativity in congenital LQTS, and scar burden for pacing response). Complementing this, multiple case reports highlight rare but consequential diagnoses—cardiac metastases, unusual tumor locations, syndromic myxomas, and atypical stress cardiomyopathy presentations—underscoring the value of multimodality imaging when standard workups are inconclusive.

Finally, the digest shows rapid growth in AI and workflow standardization for cardiac imaging. Deep learning approaches are being used for motion tracking, keyframe detection, segmentation/radiomics classification of cardiac masses, and automated RV assessment, while structured protocols (e.g., standardized fetal CMR interpretation checklists; structured MINOCA diagnostic pathways) aim to reduce variability and improve reproducibility. Together, these studies suggest a field moving from “imaging as observation” toward “imaging as quantification and decision support,” with increasing attention to implementation in real-world settings (perioperative use, adherence monitoring contexts, and pediatric/CHD feasibility).

Fetal Cardiac MRI Standardization

Value of the Newly Designed Major and Minor Checklists in Diagnosis of Congenital Cardiovascular Disease and Associated Malformation: New Era of Fetal Cardiac MRI.

This study evaluated a newly designed structured major/minor checklist for interpreting fetal cardiac magnetic resonance imaging (FCMRI) in fetuses with suspected congenital cardiovascular disease, using postnatal echocardiography as the reference standard. The structured checklist approach improved diagnostic reliability of FCMRI interpretation compared with unstructured assessment, supporting consistent classification of associated malformations. This provides a practical, standardized “new era” workflow to extend FCMRI’s role when fetal echocardiography is limited (e.g., maternal obesity, uterine fibroids, oligohydramnios, malposition, or late-gestational acoustic shadowing).

Hassan HGEMA, Ragheb SR, Elyasaki AM et al. · Academic radiology · (2026) · View on PubMed ↗

Hypertrophic Obstructive Cardiomyopathy (HOCM) & Myosin Inhibitors

Prospective evaluation of real-world safety, symptoms improvement and adherence to mavacamten among Iranian patients with hypertrophic obstructive cardiomyopathy (PERSIA-HOCM): protocol of a multicentre observational study.

This multicentre, prospective observational protocol (PERSIA-HOCM) will assess real-world safety, symptom improvement, and adherence to mavacamten in Iranian patients with hypertrophic obstructive cardiomyopathy (HOCM). The study is designed to generate prospective effectiveness and tolerability data outside randomized trials, focusing on routine clinical outcomes and adherence in a non-Western population. These results are intended to inform clinical implementation of the cardiac myosin inhibitor mavacamten in everyday practice for HOCM patients.

Ghaseminejad-Raeini A, Karimi MA, Shirinezhad A et al. · BMJ open · (2026) · View on PubMed ↗ · Free PDF ↗

Cardiovascular Magnetic Resonance (CMR) Prognosis & Risk Stratification

Vasodilator stress perfusion CMR for outcome prediction in patients under 45 years with suspected CAD.

This multicenter registry study assessed the long-term prognostic value of vasodilator stress cardiovascular magnetic resonance (CMR) for all-cause mortality in patients younger than 45 years with suspected coronary artery disease. The key finding was that stress CMR provides meaningful outcome prediction in this younger cohort, extending established prognostic evidence to patients <45. Clinically, this supports using vasodilator stress CMR for risk stratification in younger patients where coronary risk assessment is often challenging.

Vesvrotte ER, Garot J, Duhamel S et al. · Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · (2026) · View on PubMed ↗ · Free PDF ↗

Integrated left ventricular mass and left atrial function for prediction of cardiovascular outcomes: the Multi-Ethnic Study of Atherosclerosis.

This cohort analysis in the Multi-Ethnic Study of Atherosclerosis used cardiac MRI to compute an LV mass-to-left atrial (LA) strain ratio (indexed end-diastolic LV mass divided by peak LA strain) and tested whether this integrated metric predicts cardiovascular outcomes. The key finding was that the LV mass/LA strain imbalance identifies early atrioventricular mechanical uncoupling and is associated with subsequent cardiovascular events. Clinically, this provides a CMR-derived risk marker that may detect adverse remodeling earlier than LV mass or LA strain alone.

Salameh E, Hoballah M, Ebrahimihoor E et al. · American journal of physiology. Heart and circulatory physiology · (2026) · View on PubMed ↗

Incremental prognostic value of cardiac magnetic resonance beyond biomarker staging in transthyretin cardiac amyloidosis.

This multicentre retrospective study examined whether adding cardiac magnetic resonance (CMR) parameters to National Amyloidosis Centre (NAC) serum biomarker staging improves prognostication in 266 patients with transthyretin cardiac amyloidosis (ATTR-CA). Using Cox regression for time to death, the authors found that CMR predictors provided incremental prognostic value beyond NAC staging and could refine risk beyond biomarker-only stratification. Scientifically and clinically, this supports integrating CMR into ATTR-CA staging to better identify patients at higher risk and potentially guide evaluation for advanced heart failure therapies and emerging disease-modifying treatments.

Chiou T, Minga I, Subashchandran V et al. · European heart journal. Cardiovascular Imaging · (2026) · 1 citations · View on PubMed ↗

Long-term prognostic value of stress cardiovascular magnetic resonance in patients with hypertension without known coronary artery disease.

This longitudinal study assessed the long-term prognostic value of vasodilator stress cardiovascular magnetic resonance (CMR) in consecutive patients with hypertension without known coronary artery disease (CAD). In follow-up for major cardiovascular events (MACE: cardiovascular death or non-fatal MI), Cox regression was used to determine whether stress CMR findings predicted outcomes. The significance is that stress CMR may help risk-stratify hypertensive patients without known CAD for future adverse events, informing screening and preventive strategies.

Houssany-Pissot S, Garot J, Duhamel S et al. · European heart journal. Cardiovascular Imaging · (2026) · 1 citations · View on PubMed ↗

Myocardial Scar, Fibrosis & Tissue Characterization (CMR/CT/AI)

AI-Powered Detection of Left Ventricular Myocardial Scar from Dual-Sequence CT: Global and Segmental Prediction Validated by CMR.

This retrospective study developed an AI deep learning (nnU-Net) framework to detect myocardial scar from dual-sequence computed tomography (CT) by combining coronary CT angiography (CCTA) and coronary artery calcium (CAC), using cardiac magnetic resonance (CMR) as the reference standard. The model achieved accurate global and segmental scar prediction after automated cardiac segmentation and American Heart Association 17-segment subdivision. Scientifically and clinically, it suggests a CMR-sparing CT-based approach for scar detection when CMR access is limited by cost, time, or expertise.

Lu R, Yang T, Li M et al. · Journal of imaging informatics in medicine · (2026) · View on PubMed ↗ · Free PDF ↗

Reperfusion Injury & STEMI Complications

Quantitative intramyocardial hemorrhage assessment by conventional T2-weighted imaging improves risk stratification in reperfused STEMI.

In a single-center retrospective cohort of 453 reperfused ST-elevation myocardial infarction (STEMI) patients undergoing CMR a median of 5 days after reperfusion, the study quantified intramyocardial hemorrhage (IMH) using conventional T2-weighted (T2W) imaging. IMH defined as a hypointense core within edema on T2W images (expressed as a percentage of left ventricular mass) improved risk stratification for a composite of all-cause death and heart failure hospitalization. This supports a more accessible alternative to T2* mapping for prognostic assessment of severe reperfusion injury in STEMI.

Li Z, Chen Z, Zhang M et al. · The international journal of cardiovascular imaging · (2026) · View on PubMed ↗

Angiography-Based Index of Microcirculatory Resistance in Assessing the MVO and Infarct Size in STEMI Patients.

This randomized study in 123 ST-segment elevation myocardial infarction (STEMI) patients tested whether an angiography-based index of microcirculatory resistance (angio-IMR) could assess microvascular obstruction (MVO) and infarct size (IS), and whether pretreatment with 5 mg intravenous recombinant staphylokinase (r-SAK) versus normal saline (NS) altered angio-IMR. Angio-IMR derived from infarct-related arteries was used alongside cardiac magnetic resonance (CMR) to quantify MVO and IS, with the r-SAK arm showing differential post-PCI microvascular effects compared with NS (abstract truncated). Clinically, validating angio-IMR against CMR could improve early, catheter-based risk assessment of MVO/IS after PCI in STEMI and help evaluate thrombolysis strategies.

Wu T, Zhang X, Li C et al. · Clinical cardiology · (2026) · View on PubMed ↗ · Free PDF ↗

Prognostic Value of Coronary Sinus Flow and Aortic Pressure Gradient Quantified by 4D Flow CMR in AMI.

This retrospective study investigated prognostic value of 4D flow CMR-derived coronary sinus flow (CS Flow) and aortic pressure gradients in 103 patients with acute myocardial infarction (AMI) who underwent CMR before PCI. The key finding was that CS Flow (normalized to left ventricular mass) and supra-/sub-aortic valve peak pressure gradients quantified by 4D flow CMR were associated with a composite endpoint including death, unplanned revascularization, recurrent MI, heart failure rehospitalization, and stroke. This is clinically significant because it suggests 4D flow CMR metrics may add prognostic information beyond standard clinical assessment in AMI.

Li Y, Wang S, Li G et al. · Academic radiology · (2026) · View on PubMed ↗

Cardiac Tumors & Masses (Imaging/Diagnosis)

Transient Pneumopericardium During Implantation of an Extravascular Implantable Cardioverter-Defibrillator.

This JACC Case Reports report describes a 48-year-old man with ischemic cardiomyopathy (ejection fraction 14%) who underwent extravascular implantable cardioverter-defibrillator (EV-ICD) implantation after out-of-hospital cardiac arrest. During substernal tunneling, the procedure was complicated by pericardial puncture leading to transient pneumopericardium, which resolved after lead repositioning and subsequent intraoperative testing. The case highlights a specific procedural complication unique to the substernal EV-ICD route and underscores the need for vigilance for pericardial injury.

Ollitrault P, Pellissier A, Ferchaud V et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗

Four Synchronous Myxomas Unmasking Carney Complex: When to Think About Carney Complex?

This case report describes a 39-year-old man with multiple synchronous cardiac myxomas discovered on multimodality imaging (transthoracic and transesophageal echocardiography, CT, and cardiac magnetic resonance). The presence of four distinct highly mobile intracardiac lesions prompted consideration of Carney complex (CNC) as an underlying syndromic cause rather than sporadic solitary myxoma. The clinical significance is that multiple simultaneous myxomas should trigger evaluation for CNC to guide appropriate genetic and systemic workup.

Ballan G, Genovese D, Bortolato A et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗

Angiomatoid Fibrous Histiocytoma: An Exceptionally Rare Pulmonary Artery Tumor Presenting as an Asymptomatic Heart Murmur.

This case report describes a 28-year-old man with a new systolic heart murmur whose imaging revealed an exceptionally rare angiomatoid fibrous histiocytoma (AFH) arising as a pulmonary artery tumor. Transthoracic echocardiography suggested an indeterminate main pulmonary artery lesion, and cardiac magnetic resonance plus PET-CT characterized a 1.9 cm hyperintense mass attached to the pulmonic valve and pulmonary artery wall, leading to surgical resection. The significance is heightened diagnostic awareness that rare pulmonary artery tumors can present indirectly via cardiac auscultation findings.

Jafary Z, Rana S, Vaughan M et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗

AngioVac aspiration as a combined diagnostic and therapeutic strategy for an indeterminate right atrial mass in a patient with malignancy.

This case report studied a woman with active primary mediastinal large B-cell lymphoma who had an indeterminate right atrial mass discovered during evaluation for bacteremia. Because imaging could not reliably distinguish thrombus from malignant involvement and surgery was high risk, catheter-directed AngioVac aspiration was used for combined diagnostic and therapeutic debulking with successful tissue retrieval. The report suggests AngioVac may be a practical alternative when right atrial masses require tissue diagnosis but conventional biopsy or surgery carries prohibitive risk.

Abumuhfouz M, Sena A, Suleiman S et al. · Radiology case reports · (2026) · View on PubMed ↗ · Free PDF ↗

Cardiac lipoma of the right atrial appendage: Multimodality imaging of a rare tumor at an uncommon site.

This case report studied a 60-year-old woman with acute pulmonary embolism in whom a rare right atrial appendage (RAA) cardiac lipoma was incidentally discovered on CT pulmonary angiography. Multimodality imaging including cardiac MRI confirmed a fat-containing RAA mass consistent with lipoma, despite the embolic event being attributed to other causes. The report is clinically significant because it highlights an uncommon tumor location and demonstrates how multimodality imaging can characterize incidental RAA masses noninvasively.

Kosum P, Tumkosit M, Jarutasnangkul L et al. · Radiology case reports · (2026) · 1 citations · View on PubMed ↗ · Free PDF ↗

CardioRadNet: Cardiac mass diagnosis through integrated segmentation and radiomic analysis.

This study introduced CardioRadNet, an integrated deep learning segmentation plus radiomics classification framework using contrast-free T1-weighted cardiac MRI to differentiate benign from malignant cardiac masses. In 127 patients with pathologically confirmed cardiac masses (62 malignant, 65 benign), the model combined automated segmentation with radiomic features to support benign–malignant diagnosis without manual delineation. The approach could streamline and standardize cardiac mass characterization, potentially improving diagnostic efficiency and triage to appropriate therapies.

Ferretti M, Pagliaccia M, Baggiano A et al. · Computer methods and programs in biomedicine · (2026) · View on PubMed ↗ · Free PDF ↗

Isolated Myocardial Metastases in a Neuroendocrine Tumor: 68 Ga-DOTATATE PET/CT and Cardiac Magnetic Resonance Imaging Findings.

This case report described a 58-year-old man with a well-differentiated grade 1 terminal ileum neuroendocrine tumor (Ki-67 1%) undergoing 68Ga-DOTATATE PET/CT for initial staging, with incidental myocardial foci detected. Cardiac MRI demonstrated signal heterogeneity at the corresponding sites, supporting isolated myocardial metastases despite otherwise limited metastatic disease. The report highlights how somatostatin receptor-based PET/CT (68Ga-DOTATATE) combined with cardiac MRI can improve detection and characterization of rare cardiac involvement in NETs.

Baltacioglu MH, Sahin Oguz P · Clinical nuclear medicine · (2026) · View on PubMed ↗

Takotsubo Syndrome & Stress Cardiomyopathy

Psychosocial Stress-Induced Takotsubo Syndrome in a Male Patient: Breaking the Stereotype.

This JACC Case Reports article presents a 48-year-old man with psychosocial stress–triggered Takotsubo syndrome (TTS), an atypical presentation because TTS more commonly affects postmenopausal women. Cardiac magnetic resonance identified four discrete apical thrombi and he had dynamic left ventricular outflow tract obstruction, with recovery after β-blockade and anticoagulation. The report emphasizes that severe TTS complications and thrombus formation can occur even with a lower-risk trigger profile and in male patients.

Beesley H, Soroa M, Lerakis S et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗

Arrhythmias, Sudden Cardiac Death (SCD) & Risk Markers

Hidden in Plain Sight: Electromechanical Window Negativity in Congenital Long QT Syndrome.

This clinical case report describes a 19-year-old woman with KCNH2-related congenital long QT syndrome (LQTS) who had recurrent syncope triggered by abrupt auditory stimuli. Despite normal cardiac magnetic resonance and standard echocardiography, retrospective analysis identified electromechanical window (EMW) negativity, and ambulatory monitoring captured self-terminating torsades de pointes up to 273 beats/min. The finding supports EMW as a practical echocardiographic risk marker that may refine arrhythmic risk stratification beyond genotype and QTc.

Paterson T, Sanders R, Pooranachandran V · Clinical case reports · (2026) · View on PubMed ↗ · Free PDF ↗

Exercise-Induced Ventricular Tachycardia Unmasking High-Risk Anomalous Right Coronary Artery in an Adult.

This case report studied a 43-year-old adult with exercise-induced ventricular tachycardia to uncover a high-risk anomalous right coronary artery anatomy. During exercise stress testing, ventricular ectopy progressed to nonsustained ventricular tachycardia during recovery, and coronary CT angiography identified an anomalous right coronary artery arising from the left sino-coronary region. The report emphasizes that exertion-triggered arrhythmias in adults should prompt coronary anomaly evaluation because AAOCA can present later and carry sudden-death risk.

Eisa A, Rashwan R, Aldarab’ah FM et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗

Refractory Postcardiotomy Right Ventricular Failure Revealing Massive Right Ventricular Lipomatous Replacement: Autopsy-Imaging Correlation.

This autopsy-imaging correlation case report studied refractory post-cardiotomy right ventricular (RV) failure in a 76-year-old woman to determine whether massive RV lipomatous replacement represented benign fat or arrhythmogenic right ventricular cardiomyopathy (ARVC). Despite normal preoperative imaging without abnormal intramyocardial fat on standard sequences, the patient developed refractory RV failure after cardiopulmonary bypass and ultimately underwent autopsy correlation showing massive RV lipomatous replacement. The study underscores the diagnostic challenge of distinguishing lipomatous RV changes from ARVC and the clinical importance of integrating imaging with pathology when RV failure is unexplained.

Landín P, Plateros S, Campelos P et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗

Cardiovascular magnetic resonance-based arrhythmogenic substrate assessment improves sudden cardiac death risk stratification in heart failure with mildly reduced ejection fraction: a multicenter retrospective observational study.

This multicenter retrospective observational study analyzed 1855 patients with heart failure with mildly reduced ejection fraction (HFmrEF) to determine whether cardiovascular magnetic resonance (CMR) markers—late gadolinium enhancement (LGE) and T1 mapping—improve sudden cardiac death (SCD) risk stratification. Using development (n=1417) and external validation (n=438) cohorts, the study tested a CMR-based algorithm incorporating LGE and T1 mapping to better predict SCD than standard approaches (abstract truncated). Scientifically and clinically, CMR tissue characterization may refine SCD prevention strategies in HFmrEF by identifying arrhythmogenic substrate more accurately.

Wang W, Zhu R, Gao Y et al. · The Lancet regional health. Western Pacific · (2026) · View on PubMed ↗ · Free PDF ↗

[Interarterial anomalous right coronary artery in a competitive athlete: case report].

This case report described a 37-year-old competitive endurance athlete in whom pre-participation screening identified an anomalous right coronary artery originating from the left sinus of Valsalva with an interarterial course and intramural segment. Coronary computed tomography angiography demonstrated high-risk anatomical features associated with exertional ischemia and sudden cardiac death risk (abstract truncated). The significance is that dynamic risk assessment in athletes plus CT-based anatomical characterization can inform eligibility and management decisions.

Lodi E, Tardini L, Poli ML et al. · Giornale italiano di cardiologia (2006) · (2026) · View on PubMed ↗

Blood-nulled late gadolinium enhancement increases sensitivity for subtle basal myocardial scar in mitral valve prolapse with annular disjunction.

This case report evaluated whether blood-nulled late gadolinium enhancement (LGE) CMR improves detection of subtle basal myocardial scar in a 67-year-old woman with mitral valve prolapse (MVP) and mitral annular disjunction (MAD). The key finding was that blood-nulled LGE increased sensitivity for a small (3-mm) basal inferolateral/subendocardial scar that can be obscured on conventional bright-blood LGE. Clinically, this suggests blood-nulled LGE may enhance CMR risk stratification for arrhythmogenic MVP/MAD phenotypes when fibrosis is subtle.

Avakian A, Umair M · Radiology case reports · (2026) · View on PubMed ↗ · Free PDF ↗

Prognostic Value of MRI-Based Left Ventricular Trabecular Complexity for Sudden Cardiac Death in Hypertrophic Cardiomyopathy.

This prospective study assessed whether MRI-derived left ventricular trabecular complexity quantified by fractal dimension (FD) predicts sudden cardiac death in 835 hypertrophic cardiomyopathy (HCM) patients, using 3T steady-state free precession (SSFP) cine CMR with blinded image readers. Higher LV trabecular complexity (FD) was associated with increased SCD risk and showed relationships with sarcomere gene variants. The findings support FD-based CMR trabecular complexity as a quantitative risk stratification biomarker that may refine prevention strategies in HCM.

Zhang J, Yu M, Pu L et al. · Journal of magnetic resonance imaging : JMRI · (2026) · 1 citations · View on PubMed ↗ · Free PDF ↗

Cardiac Imaging AI/Deep Learning & Automated Quantification

Creating bottom-up RNA transfer vehicles from synthetic protein assemblies.

The study investigated whether AI-designed synthetic protein assemblies can be functionalized as bottom-up RNA transfer vehicles independent of viral evolutionary constraints. The authors report that nucleic-acid transport functionality can be engineered by combining designed protein architectures with nucleic acid cargo to create virus-like delivery systems. This provides a generative-design route to programmable RNA delivery platforms that could complement or replace evolution-derived viral vectors.

Schuhmacher MK, Gruber C, Lang CMR et al. · Nature · (2026) · View on PubMed ↗ · Free PDF ↗

The role of artificial intelligence in the diagnosis of pericardial constriction.

This narrative review evaluated the role of artificial intelligence (AI) in diagnosing pericardial constriction (constrictive pericarditis) and distinguishing it from restrictive cardiomyopathy. The key finding was that the strongest existing evidence involves machine learning/deep learning applied to echocardiography, with emerging approaches expanding to other imaging modalities. Scientifically, it supports ongoing development of AI-assisted multimodal diagnostic workflows for a condition where accurate differentiation is critical.

Lipat K, Booth T, Sengupta PP · Current opinion in cardiology · (2026) · View on PubMed ↗

Spatial phenotyping of epicardial adipose tissue from cardiac MRI.

This study developed a deep learning framework to spatially phenotype epicardial adipose tissue (EAT) distribution from cardiac MRI by combining automated segmentation with spatial statistical modeling. The key finding was that an asymmetric multi-modal CNN-Transformer network could segment the four cardiac chambers and EAT and then enable quantitative, chamber-resolved characterization of EAT distribution across the whole heart. This advances CVD research by providing a more detailed, spatially resolved EAT measurement tool than conventional global or coarse segmentation approaches.

Feng F, Long T, Hasaballa AI et al. · Medical image analysis · (2026) · View on PubMed ↗ · Free PDF ↗

Deformable image registration for self-supervised cardiac phase detection in cardiac magnetic resonance images of patients with various diseases.

This work developed a self-supervised deep learning method for detecting cardiac keyframes in short-axis (SAX) and four-chamber (4CH) cine CMR using dense deformable image registration to derive motion descriptors. The model automatically detected five keyframes in SAX and four keyframes in 4CH, enabling more detailed sub-phase analysis than approaches limited to end-systole and end-diastole. This technique could improve automated CMR analysis across diverse cardiac diseases by providing robust, motion-aware temporal localization.

Mueller SK, Koehler S, Kiekenap J et al. · Medical image analysis · (2026) · View on PubMed ↗ · Free PDF ↗

ContiMorph: An unsupervised learning framework for cardiac motion tracking with time-continuous diffeomorphism.

This paper developed ContiMorph, an unsupervised deep learning framework for cardiac motion tracking in cardiac image sequences using time-continuous diffeomorphism rather than relying on scaling-and-squaring (SS) integration. The key finding is that ContiMorph uses a frame-aware U-Net plus a time-embedded transformer to learn temporally continuous intra-frame motion fields, improving tracking accuracy by better exploiting temporal continuity. This is significant for more reliable cardiac motion quantification in imaging-based functional assessment and downstream cardiovascular diagnosis.

Jiang M, Ruan X, Zheng L et al. · Medical image analysis · (2026) · View on PubMed ↗

Artificial intelligence for right ventricular assessment: current evidence and future directions.

This review synthesized evidence on using artificial intelligence (AI) for right ventricular (RV) structural and functional assessment across echocardiography, cardiac MRI (CMR), and computed tomography (CT) in clinical settings such as pulmonary hypertension, valvular disease, and congenital heart disease. Overall, AI-based automated RV segmentation and chamber quantification has achieved accuracy approaching interobserver variability, reducing interpreter dependence. The review positions AI as a practical pathway to more reproducible RV phenotyping for risk stratification and longitudinal monitoring, while outlining key validation and implementation needs.

Tan X, Fowler J, Li M et al. · Current opinion in cardiology · (2026) · 1 citations · View on PubMed ↗

CardioMorphNet: Cardiac motion prediction using a shape-guided Bayesian recurrent deep network.

This study developed and tested CardioMorphNet, a shape-guided Bayesian recurrent deep network for 3D cardiac motion prediction using short-axis (SAX) cine cardiac MRI in order to improve deformable registration. By incorporating a recurrent variational autoencoder to model spatiotemporal dependencies across the cardiac cycle and using posterior models for biventricular segmentation, the method addresses intensity-only registration losses that can miss anatomical regions. If validated broadly, CardioMorphNet could enhance CMR-based motion estimation for more reliable cardiac function assessment and detection of abnormalities.

Movahed RA, Rezaee A, Zakeri A et al. · Medical image analysis · (2026) · View on PubMed ↗ · Free PDF ↗

Systemic Diseases with Cardiac Involvement (SSc, Sarcoid, etc.)

Depressed LV Contractility as a Sentinel of Fulminant Systemic Scleroderma.

This case report studied rapidly progressive systemic scleroderma in a 21-year-old man, focusing on depressed left ventricular (LV) contractility as a sentinel of fulminant cardiac involvement. Cardiac MRI showed diffuse gadolinium enhancement and endomyocardial biopsy demonstrated mast cell infiltration with early fibrosis, followed by rapid deterioration despite guideline-directed therapy and cyclophosphamide. The findings highlight that early LV dysfunction with inflammatory biopsy features may signal impending fulminant systemic sclerosis cardiomyopathy and the need for urgent escalation.

Luo M, Branch T, Vasoya D et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗

Rapidly Progressive Myocarditis and Cardiogenic Shock: The Failing Heart in Systemic Sclerosis.

This case report studied a 49-year-old woman with diffuse systemic sclerosis (SSc) presenting with rapidly progressive myocarditis and cardiogenic shock. Cardiac MRI showed diffuse biventricular myocardial inflammation and endomyocardial biopsy confirmed lymphocytic infiltration, with severe biventricular systolic dysfunction on echocardiography. The report highlights that fulminant lymphocytic myocarditis can be an under-recognized, life-threatening initial cardiac manifestation of SSc requiring prompt recognition and aggressive management.

Mohammad F, Alhajri N, Al-Matrooshi N et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗

Left ventricular myocardial strain analysis by feature tracking cardiac magnetic resonance in patients with autoimmune rheumatic diseases: A case-control study.

This case-control study assessed whether left ventricular myocardial strain measured by cardiac magnetic resonance feature tracking (CMR-FT) can detect subclinical myocardial dysfunction in 30 patients with autoimmune rheumatic diseases (ARDs) versus 10 matched healthy controls. CMR-FT–derived strain parameters were evaluated as more sensitive markers than conventional cardiac function measures for early cardiac involvement (abstract truncated). If validated, CMR-FT could improve screening and risk stratification for cardiotoxicity in ARDs before overt dysfunction appears.

ElMahdy EKA, Ibrahim AS, AbdulRahim SAA et al. · La Clinica terapeutica · (2026) · View on PubMed ↗

Multidisciplinary approach in cardiac sarcoidosis: to biopsy or not?

This review synthesized evidence on cardiac sarcoidosis diagnosis, focusing on whether endomyocardial biopsy (EMB) remains necessary within a multidisciplinary diagnostic approach. It emphasizes that EMB has limited sensitivity with false negatives and procedural risks, while noninvasive imaging is increasingly relied upon due to patchy myocardial involvement. The clinical significance is guidance on when tissue diagnosis may still be warranted versus when imaging-based strategies may suffice in modern practice.

Pericao A, Sharma R · Current opinion in pulmonary medicine · (2026) · View on PubMed ↗

Heart involvements in systemic sclerosis beyond pulmonary hypertension: From conduction, rhythm and function defects to coronary artery disease.

This narrative review summarized cardiac involvement in systemic sclerosis (SSc) beyond pulmonary hypertension, covering conduction, rhythm, and function defects as well as coronary artery disease and microvascular dysfunction. The key finding is that, even independent of pulmonary arterial hypertension, cardiac disease in SSc is common but often underestimated, with clinically manifest disease in roughly 15–35% and subclinical dysfunction in about 70% when advanced screening is used. Scientifically and clinically, it emphasizes the need for comprehensive cardiac evaluation in SSc to reduce morbidity and mortality from diverse cardiac complications.

Barile R, Rotondo C, Giancaspro G et al. · La Revue de medecine interne · (2026) · View on PubMed ↗

Congenital/Genetic Cardiomyopathies & Channelopathies

Cardiac-Predominant Fukutinopathy Caused by Novel Compound Heterozygous FKTN Variants: A Diagnostic and Genetic Odyssey.

This case report studied a 30-year-old man with cardiac-predominant fukutinopathy to define the genetic cause of his dilated cardiomyopathy and persistent QT prolongation. Whole-exome sequencing identified compound heterozygous FKTN variants (c.1112A>G [p.Tyr371Cys] likely pathogenic and c.1224G>T [p.Lys408Asn] of uncertain significance) confirmed by parental Sanger sequencing. The report supports genotype-directed evaluation in atypical, cardiac-only dystroglycanopathy presentations and refines diagnostic pathways for FKTN-related disease.

Imayavaramban B, Kumar P, Chowdhury RR et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗

Sudden Cardiac Arrest and Takotsubo-Like Cardiomyopathy as the Initial Presentation of Primary Carnitine Deficiency.

This case report studied an 18-year-old female with primary carnitine deficiency (PCD) presenting with sudden cardiac arrest and Takotsubo-like cardiomyopathy. Genetic testing identified a homozygous pathogenic SLC22A5 variant (c.43G>T; p.Gly15Trp), and cardiac MRI supported a Takotsubo-like phenotype despite normal anatomy. The findings reinforce that PCD can present with fatal arrhythmias and reversible cardiomyopathy, supporting early genetic testing and timely carnitine-cycle targeted therapy.

Talasani N, Przybylski R, Delaney MA et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗

Phenotypic overlap masking MELAS in Turner syndrome: a diagnostic challenge.

This case report evaluated diagnostic overlap masking MELAS in a 51-year-old woman with mosaic Turner syndrome presenting with concentric left ventricular hypertrophy and mildly reduced systolic function. The clinical phenotype overlapped with other genetic cardiomyopathies, creating a diagnostic challenge for MELAS recognition (abstract truncated). The significance is that careful genetic and metabolic evaluation is needed when cardiomyopathy features in Turner syndrome obscure mitochondrial disease, to avoid mismanagement.

Shinozaki T, Sumiyoshi H, Ueshima D et al. · European heart journal. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗

This case report described a 44-year-old man with suspected PRKAG2-related cardiomyopathy, a metabolic phenocopy of hypertrophic cardiomyopathy, presenting with ventricular hypertrophy and pre-excitation. Cardiac magnetic resonance showed asymmetric hypertrophy with extensive late gadolinium enhancement and early adverse remodeling, suggesting an overlap phenotype between hypertrophic cardiomyopathy and arrhythmogenic left ventricular cardiomyopathy, and genetic testing confirmed a PRKAG2 variant (abstract truncated). Clinically, recognizing PRKAG2-related disease can prevent misclassification and guide appropriate preventive therapy such as primary prevention implantable cardioverter-defibrillator placement.

Quadrini F, Rodio D, Maddaluna P et al. · Giornale italiano di cardiologia (2006) · (2026) · View on PubMed ↗

Pulmonary Hypertension & Right Heart Function

Optimal Strain Combinations for Prognostic Prediction in Pulmonary Arterial Hypertension.

This prospective study evaluated prognostic value of myocardial strain parameters in patients with pulmonary arterial hypertension, analyzing left ventricular global longitudinal strain, right ventricular GLS (including right ventricular free-wall longitudinal strain), and right atrial phasic strain. Using elastic net Cox regression and stepwise Cox regression with Akaike information criterion feature selection, the authors identified optimal strain combinations that predicted all-cause mortality and a composite endpoint. Clinically, the work supports using specific multi-chamber strain patterns to improve risk stratification in pulmonary arterial hypertension.

Guo J, Leng S, He J et al. · Circulation. Heart failure · (2026) · View on PubMed ↗

Sequential Changes in Right Ventricular Straein During the Development of Pulmonary Hypertension Assessed With Magnetic Resonance Feature Tracking: An Animal Study.

This animal study used cardiac magnetic resonance (CMR) feature tracking (FT) to measure sequential right ventricular (RV) strain in Wistar rats during pulmonary hypertension (PH) development after monocrotaline injection, with histological vascular remodeling assessed at 1–4 weeks. RV strain changes over time were evaluated for correlation with the degree of vascular remodeling across PH and vehicle-injected control groups (abstract truncated). Scientifically, CMR-FT–based RV strain trajectories may provide a noninvasive biomarker of PH progression and remodeling dynamics.

Kim NY, Im DJ, Hong YJ et al. · Korean journal of radiology · (2026) · View on PubMed ↗ · Free PDF ↗

5D Flow MRI Reveals Respiration-Driven Changes in Blood Flow Energetics in Congenital Heart Disease.

This study used 5D flow MRI to quantify respiration-driven changes in blood flow energetics in patients with right-sided congenital heart disease (CHD). In 14 Fontan patients, 10 intracardiac shunt patients, and 9 controls, the authors measured kinetic energy and viscous energy loss/inefficiency across four respiratory states (full quantitative results truncated). Demonstrating respiratory modulation of flow energetics with 5D flow MRI could improve hemodynamic monitoring and interpretation of pulmonary flow efficiency in CHD beyond standard 4D flow approaches.

Nallamothu T, Weiss EK, Baraboo J et al. · Magnetic resonance in medicine · (2026) · View on PubMed ↗ · Free PDF ↗

Pericardial Disease (Constrictive/Effusion/Pericarditis)

ECMO-Supported Pericardiectomy in Constrictive Tuberculous Pericarditis With Severe Ventricular Dysfunction.

This case report studied a 20-year-old man with constrictive tuberculous pericarditis complicated by severe biventricular systolic dysfunction (LVEF <15%). After negative conventional TB investigations and lack of improvement with empirical antituberculosis therapy and heart failure management, he underwent ECMO-supported radical pericardiectomy for cardiogenic shock. The report suggests that in severe TB-related constriction with profound ventricular dysfunction, surgical pericardiectomy with temporary mechanical circulatory support can be lifesaving.

Elmorshidy M, Helal A, El-Din M et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗

When rare meets rarer: constrictive pericarditis in Erdheim-Chester disease-a case report.

This case report described a 57-year-old man with multisystem Erdheim-Chester disease (ECD) who developed exceptionally rare constrictive pericarditis. Multimodality imaging showed marked pericardial thickening with constrictive physiology on echocardiography, diffuse late gadolinium pericardial enhancement on cardiac magnetic resonance, and circumferential periarterial infiltration on computed tomography (abstract truncated). The report highlights that MAPK-driven ECD can cause clinically significant pericardial constriction and that CMR can be pivotal for diagnosis and extent-of-disease assessment.

Dimova-Mileva M, Kanchev I, Marinova E et al. · European heart journal. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗

Pathway for the Diagnosis and Management of Pericardial Disease: Contemporary Perspective.

This contemporary perspective article reviewed and proposed a pathway-based diagnostic and management framework for pericardial disease across clinical scenarios such as chest pain, hemodynamic collapse, dyspnea, and other presentations. The key finding is that updated European Society of Cardiology and American College of Cardiology consensus guidance—incorporating improved phenotyping, multimodal imaging, and targeted immunomodulatory therapies—can be operationalized into structured clinical pathways. This is significant because it aims to standardize real-world decision-making and improve timely, scenario-appropriate care for pericardial syndromes.

Sivalokanathan S, Herzog E, Haider SW et al. · Critical pathways in cardiology · (2026) · View on PubMed ↗ · Free PDF ↗

Hemorrhagic eosinophilic pericardial effusion associated with probable sparganosis.

This case report studied a 25-year-old man who developed hemorrhagic eosinophilic pericardial effusion after ingesting undercooked frog meat, with diagnostic workup for sparganosis caused by Spirometra larvae. Despite extensive testing including cultures, cytology, cross-sectional imaging, cardiac MRI, PET/CT, and next-generation sequencing, the clinical picture was supported by peripheral eosinophilia, eosinophils in pericardial fluid, markedly elevated IgE, and positive serology by enzyme-linked immunosorbent assay. The report highlights that sparganosis should be considered in hemorrhagic eosinophilic pericardial effusion after relevant food exposure, even when standard microbiologic and imaging evaluations are unrevealing.

Zhu Y, Wang D, Wu Y et al. · International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · (2026) · View on PubMed ↗ · Free PDF ↗

HIV Care Delivery & Adherence Support

Evolution of ART Medication Adherence Support and Monitoring Across IeDEA Sites: Results From Three Waves of Consortium-Wide Site Assessment Surveys, 2017, 2020 and 2023.

This consortium-wide survey study evaluated how ART adherence support and monitoring recommendations were implemented across IeDEA sites in adults with HIV using serial cross-sectional assessments in 2017, 2020, and 2023. Across 43 countries (with 131 clinics completing all three waves), the authors characterized clinic resources and routine adherence support/monitoring practices over time. The results provide actionable evidence on gaps and trends in adherence-support implementation that can inform improvements in HIV care delivery.

Brazier E, Odhiambo F, Edwards JK et al. · Journal of the International AIDS Society · (2026) · View on PubMed ↗ · Free PDF ↗

Managing pregnancy in women with pre-existing cardiomyopathies: A case series.

This case series described pregnancy management and outcomes in women with pre-existing cardiomyopathies, focusing on dilated, hypertrophic, and arrhythmogenic phenotypes. Key complications managed included arrhythmias, rising left ventricular outflow tract obstruction, and heart failure across pregnancy, delivery, and postpartum periods (abstract truncated). The significance is that phenotype-specific planning with biomarkers and tailored pharmacologic/device management can reduce maternal–fetal risk in cardiomyopathy pregnancies.

Bruce C, Montanaro C, Wander G et al. · Case reports in women’s health · (2026) · View on PubMed ↗ · Free PDF ↗

Cardiac volumes, function, and arterial stiffness five years after severe preeclampsia: A comparison with sedentary and active controls.

This study compared cardiac volumes, function, and arterial stiffness five years after severe preeclampsia in 10 women with severe preeclampsia versus 20 normotensive pregnancy controls, including lifestyle-matched and physically active subgroups. Using cardiac magnetic resonance (CMR), the investigators assessed long-term cardiovascular impact and related it to activity level and arterial stiffness measures (abstract truncated). The findings are clinically relevant for identifying women at elevated future cardiovascular risk after severe preeclampsia and for evaluating whether physical activity modifies that risk.

Edvinsson C, Steding-Ehrenborg K, Venkateshvaran A et al. · Clinical physiology and functional imaging · (2026) · View on PubMed ↗ · Free PDF ↗

Heart Failure & Ventricular Remodeling (including Strain/ECV)

Lower- Versus Conventional-Sodium Dialysate and Left Ventricular Mass in Patients Receiving Hemodialysis: Causal Analyses of a Randomized Clinical Trial.

This study used causal pathway modeling within a randomized clinical trial in home and self-care satellite hemodialysis patients to explain why allocation to lower dialysate sodium ([Na+]) did not reduce left ventricular mass index (LVMI) measured by cardiac magnetic resonance imaging. Lower [Na+] reduced interdialytic weight gain and B-type natriuretic peptide (BNP) and suggested less extracellular fluid volume by bioimpedance, but the modeled causal effects did not translate into a measurable LVMI reduction. These findings refine mechanistic expectations for dialysate sodium strategies and highlight that BNP/volume changes may not be sufficient to reverse LV remodeling on the studied timescale.

Marshall MR, Vandal AC, Chan CT et al. · Kidney medicine · (2026) · View on PubMed ↗ · Free PDF ↗

Precision-guided heart failure interventions: The expanding role of advanced cardiac imaging and artificial intelligence.

This review article discussed precision-guided heart failure interventions and emphasized how advanced cardiac imaging and artificial intelligence are increasingly used to guide therapy selection and procedural planning. The key finding was that imaging-driven phenotyping across anatomy, myocardial substrate, and physiology is central to tailoring interventions such as transcatheter valve therapies, cardiac resynchronization/pacing, complex coronary interventions, invasive hemodynamic assessment, and implantable pressure sensors. The clinical significance is improved personalization of heart failure care as treatment options expand beyond pharmacology.

Albulushi A, Al-Farhan H · American heart journal plus : cardiology research and practice · (2026) · View on PubMed ↗ · Free PDF ↗

The Relationship Between Physical Activity and Left Ventricular Remodeling in Childhood Cancer Survivors Treated With Anthracyclines: A Cross-Sectional Study.

This cross-sectional study in childhood cancer survivors treated with anthracyclines examined how moderate-to-vigorous physical activity (MVPA), measured by accelerometry, relates to cardiac remodeling assessed by cardiovascular magnetic resonance. The key finding was the association between MVPA and CMR-derived remodeling parameters including indexed end-diastolic LV mass (LVMi), LV end-diastolic volume (LVEDVi), mass:volume ratio, and LV ejection fraction (LVEF). Scientifically and clinically, it supports physical activity as a potentially modifiable factor influencing early anthracycline-related cardiac changes.

Narayan HK, Chen S, Wong FL et al. · Pediatric blood & cancer · (2026) · View on PubMed ↗

Enhanced risk stratification in hypertrophic cardiomyopathy through the integration of extracellular volume fraction on cardiovascular magnetic resonance.

This study analyzed 990 consecutive hypertrophic cardiomyopathy (HCM) patients undergoing cardiovascular magnetic resonance (CMR) to test whether extracellular volume fraction (ECV) adds prognostic value beyond late gadolinium enhancement (LGE). Higher global ECV was associated with increased risk of HCM-related events (including sudden cardiac death, heart failure events, and HCM-related death) and improved risk stratification over LGE alone. These findings support incorporating CMR-derived ECV as a marker of diffuse interstitial fibrosis to better predict outcomes in HCM.

Lee HJ, Gwak SY, Lee S et al. · European heart journal. Cardiovascular Imaging · (2026) · 1 citations · View on PubMed ↗

Left atrial reservoir strain for predicting progression to end-stage in hypertrophic cardiomyopathy.

This multicenter observational study analyzed 925 patients with hypertrophic cardiomyopathy (HCM) followed with echocardiography to identify predictors of progression to end-stage HCM, defined as left ventricular ejection fraction (LVEF) <50% without reversible causes. It focused on whether left atrial reservoir strain measured at baseline predicted progression, with a CMR subcohort of 491 patients for additional characterization. The clinical significance is that left atrial reservoir strain could provide a noninvasive prognostic biomarker to identify HCM patients at higher risk of deterioration toward end-stage disease.

Kwak S, Jeong MH, Park CS et al. · European heart journal. Cardiovascular Imaging · (2026) · 1 citations · View on PubMed ↗

Lead-Site Myocardial Scar Predicts Echocardiographic Response to Left Bundle Branch Area Pacing.

This retrospective clinical study assessed whether lead-site myocardial scar burden predicts echocardiographic response to left bundle branch area pacing (LBBAP) in heart failure patients with left bundle branch block (LBBB). Among 87 HF patients with LBBB and LVEF ≤35% who underwent cardiac MRI and successful LBBAP, scar at the lead deployment site was evaluated against a 6-month echocardiographic response definition (full statistical results truncated). If scar burden at the pacing site predicts response, CMR-based scar assessment could personalize patient selection and improve resynchronization outcomes with LBBAP.

Yin F, Xu S, Qian Z et al. · Pacing and clinical electrophysiology : PACE · (2026) · View on PubMed ↗

Cardiovascular Imaging Cost-Effectiveness & Policy

A cross-sectional online survey evaluating how anaesthesiologists view cardiovascular magnetic resonance imaging reports as a tool for perioperative risk evaluation.

This cross-sectional online survey assessed how anaesthesiologists perceive and use cardiovascular magnetic resonance (CMR) findings for perioperative cardiovascular risk evaluation. The key finding was the degree to which preexisting CMR results were incorporated into perioperative decision-making and which factors predicted CMR use and understanding (as reported in the survey results). Clinically, the study identifies gaps in adoption and interpretation of CMR reports that could affect perioperative risk stratification in patients with cardiovascular disease.

Fischer K, Harms R, Fini JN et al. · BJA open · (2026) · View on PubMed ↗ · Free PDF ↗

Cost-effectiveness of imaging modalities in coronary heart disease: A comprehensive review.

This comprehensive review assessed the cost-effectiveness of coronary heart disease imaging modalities, focusing on myocardial perfusion imaging (MPI) using SPECT and PET. The review summarizes economic evidence indicating that modality choice should be aligned with clinical indications and evolving technology to optimize value. Clinically, it supports more deliberate selection of SPECT vs PET MPI strategies to balance diagnostic benefit and healthcare costs in coronary heart disease.

Milan E, Giubbini R, Vitola J et al. · Seminars in nuclear medicine · (2026) · 1 citations · View on PubMed ↗

Other (Non-cardiac) Biomarkers & Mechanistic Studies

Data-source choice in diabetes mortality surveillance and equity monitoring in the United States, 1999-2023.

This US population study compared diabetes mortality surveillance conclusions across 51 jurisdictions from 1999–2023 using two data sources—CDC WONDER versus Global Burden of Disease 2023 (GBD 2023)—to evaluate effects on trends, high-burden classification, and income-related inequality. The key finding was that the choice of data source can change observed mortality rates and downstream conclusions about where the highest burden lies and how inequality evolves over time. Scientifically and for public health equity monitoring, this demonstrates that surveillance policy decisions should account for source-dependent discrepancies.

Li WJ, Tao SS, Wang P et al. · Diabetes research and clinical practice · (2026) · View on PubMed ↗

SMARCA4, STK11, and KEAP1 co-inactivation associates with poor prognosis and upregulation of the TGF-β pathway in lung adenocarcinoma.

This study analyzed co-inactivation of the tumor suppressor genes SMARCA4, STK11, and KEAP1 in lung adenocarcinoma (LUAD) and assessed associated pathway activity, including TGF-β signaling. Co-inactivation was linked to poor prognosis and was associated with upregulation of the TGF-β pathway. These findings support using multigene loss patterns (SMARCA4/STK11/KEAP1) to refine risk stratification and identify TGF-β pathway–targetable biology in LUAD.

Costa EA, Mello BP, Wohlhieter C et al. · Translational oncology · (2026) · View on PubMed ↗ · Free PDF ↗

Cardiac Safety Outcomes in Delandistrogene Moxeparvovec Clinical Trials for Duchenne Muscular Dystrophy with Up to 5 Years of Follow-up.

This study assessed cardiac safety outcomes of the gene transfer therapy delandistrogene moxeparvovec (delivers a functional dystrophin gene product) in clinical trials for Duchenne muscular dystrophy (DMD) with up to 5 years of follow-up. Across trials 101, 102, ENDEAVOR, and EMBARK (excluding baseline LVEF <40%), adverse events and serial cardiac echocardiography were used to characterize cardiac safety, with troponin I monitored regularly. These findings support longer-term cardiac safety characterization for delandistrogene moxeparvovec in DMD populations relevant to clinical adoption and monitoring strategies.

Veerapandiyan A, Bourke J, Soslow JH et al. · Cardiology and therapy · (2026) · View on PubMed ↗ · Free PDF ↗

Microvascular dysfunction and neurovascular signalling impairment in diabetic silent myocardial ischemia.

This article reviewed mechanisms of diabetic silent myocardial ischemia (DSMI) in the context of coronary microvascular dysfunction and impaired neurovascular signaling driven by chronic hyperglycemia. It highlights that oxidative stress, advanced glycation end-product (AGE) accumulation, and mitochondrial dysfunction reduce nitric oxide (NO) bioavailability and worsen coronary flow reserve and capillary integrity while diabetic peripheral/autonomic neuropathy blunts nociceptive signaling. Clinically, targeting microvascular and neurovascular pathways may improve detection and treatment of DSMI, a high-risk condition that presents without typical angina symptoms.

Rajasekaran HK · Microvascular research · (2026) · View on PubMed ↗

Outcomes From the Multicenter ACCRU-LY-1804/CARiBOU TRIAL (Cytarabine, Acalabrutinib and Rituximab Integrated With Bortezomib-Based Outpatient Therapy) in 1st Line Mantle Cell Lymphoma.

This phase 2 multicenter ACCRU-LY-1804/CARiBOU trial evaluated first-line mantle cell lymphoma (MCL) treatment using a multitarget regimen combining cytarabine, acalabrutinib, and rituximab integrated with bortezomib-based outpatient therapy. The study’s key outcomes included complete metabolic response (CMR) rate and safety/feasibility endpoints such as stem cell collection and progression-free and overall survival. If effective and tolerable, this regimen could improve the depth and durability of response in previously untreated MCL by integrating BTK inhibition (acalabrutinib) with chemoimmunotherapy and proteasome inhibition (bortezomib).

Smith SD, Sundaram S, Giri S et al. · American journal of hematology · (2026) · View on PubMed ↗ · Free PDF ↗

Size-resolved microelectrical effects of fine aerosol on nocturnal ozone: Evidence from field observations and statistical modeling.

This field study investigated how particle electrical properties—specifically particle charge-to-mass ratio (CMR)—relate to nocturnal ozone (O3) enhancement in Xi’an during 2023–2025 using statistical modeling (generalized additive models and PLS-SEM) and an interfacial contribution model. The key finding was that particle CMR was significantly associated with variations in nocturnal O3 under stable nocturnal conditions, beyond meteorological transport effects. Scientifically, it supports a role for aerosol electrical properties in nocturnal O3 chemistry and helps refine atmospheric models of nighttime air quality.

Wang Y, Zhang L, Li J et al. · Environmental research · (2026) · View on PubMed ↗

Repurposing Empagliflozin for Duchenne Muscular Dystrophy-Associated Cardiomyopathy: Protocol for a Pharmacokinetics, Safety and Proof-of-Concept Trial in Children.

This protocol describes a single-arm, open-label phase 2 pharmacokinetics, safety, and proof-of-concept trial repurposing empagliflozin in children with Duchenne muscular dystrophy (DMD)-associated cardiomyopathy. The study will characterize empagliflozin pharmacokinetics, assess safety and ease-of-swallow, and explore efficacy and efficacy markers in this pediatric population. If successful, it would provide early translational evidence for SGLT2 inhibition as a disease-modifying or cardioprotective strategy in DMD-related heart failure.

Lava SAG, Laurence C, Mallory J et al. · Cardiology and therapy · (2026) · View on PubMed ↗ · Free PDF ↗

Reversible alterations of brain acetate metabolism associated with alcohol consumption.

This study examined how alcohol consumption alters brain acetate metabolism in four groups—light drinkers, at-risk heavy drinkers, alcohol use disorder (AUD) patients in long-term recovery, and AUD treatment-seekers—using medically supervised detoxification with scanning at about one week abstinence. The results showed reversible changes in brain acetate metabolism associated with alcohol exposure and abstinence status, consistent with prior observations that alcohol shifts brain fuel utilization between glucose and acetate pathways. These findings improve mechanistic understanding of alcohol-related metabolic adaptations and may inform biomarker development for AUD severity or treatment response.

Kumaragamage C, Jiang L, Angarita GA et al. · Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · (2026) · View on PubMed ↗ · Free PDF ↗

Intraoperative study of afferent and efferent connections in the upper lumbar spinal cord - Part 1: Cremasteric reflex.

This intraoperative neurophysiology study assessed the feasibility and stimulation/recording parameters of the cremasteric reflex (CMR) in male patients undergoing spinal surgery under general anesthesia. Electrical stimulation of the upper medial thigh using a multipulse train produced cremaster muscle responses in 23 of 30 muscles across 15 participants, with an overall recordability rate of 76% (latency/other metrics truncated). Demonstrating reliable intraoperative recording of the cremasteric reflex may support mapping of upper lumbar spinal cord afferent/efferent pathways during surgery.

de Melo DLM, Oliveira DRDCAB, Madureira PLDS et al. · Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · (2026) · View on PubMed ↗

Survival of patients with complete metabolic response on [18F]FDG PET/CT after chemotherapy prior to transplantation for colorectal liver metastases.

This study evaluated survival outcomes after liver transplantation for colorectal liver metastases (CRLM) in patients who achieved complete metabolic response (CMR) on pre-transplant [18F]FDG PET/CT following chemotherapy. Among 45 patients from SECA 1 and 2, metabolic tumor volume (MTV) derived from [18F]FDG PET/CT was used to stratify patients into MTV 0 (CMR), MTV low, and MTV high groups, and the abstract truncates the specific survival comparisons. If PET/CT-defined CMR (MTV=0) predicts better disease-free and overall survival post-transplant, it could improve selection and prognostication for CRLM transplantation.

Stern NM, Dueland S, Line PD et al. · Scandinavian journal of surgery : SJS : official organ for the Finnish Surgical Society and the Scandinavian Surgical Society · (2026) · 1 citations · View on PubMed ↗ · Free PDF ↗

Cardiac Imaging in Pediatrics & Congenital Heart Disease

Advanced Cardiac Imaging Techniques for Detection of Myocardial Ischemia in Children with Coronary Artery Abnormalities.

This review summarized advanced cardiac imaging techniques for detecting myocardial ischemia in children with coronary artery abnormalities due to non-atherosclerotic causes such as Kawasaki disease vasculopathy, transplant-related allograft vasculopathy, congenital coronary anomalies, and post–coronary reimplantation complications. The key finding was that ischemia detection in this pediatric setting requires multimodality imaging strategies because symptoms are often absent or atypical and standard screening (e.g., resting ECG) is limited. The clinical significance is improved diagnostic accuracy and earlier identification of ischemia risk in children with diverse coronary pathologies.

Jin JB, Williams JL, Wang SM et al. · Cardiology and therapy · (2026) · View on PubMed ↗ · Free PDF ↗

Non-invasive detection of acute cell-mediated graft rejection in paediatric heart transplant recipients: The role of cardiovascular magnetic resonance.

This prospective study in 15 pediatric heart transplant recipients used multiparametric, contrast-enhanced cardiovascular magnetic resonance (CMR) followed by endomyocardial biopsy (EMB) and right heart catheterization to detect acute cell-mediated graft rejection non-invasively. Multiparametric CMR parameters and rejection-associated textural features of parametric maps distinguished rejection from non-rejection cases. This supports CMR as a potential non-invasive adjunct to EMB for monitoring acute rejection in children after heart transplantation.

Gesuete V, Ragni L, Niro F et al. · International journal of cardiology. Congenital heart disease · (2026) · View on PubMed ↗ · Free PDF ↗

Pathophysiologic Consequences of Early Coarctation Stenting in a Longitudinal Porcine Model.

This study used a longitudinal porcine model of surgically induced coarctation of the aorta (COA) to compare sham animals, COA controls, and COA animals receiving early intravascular stent implantation with serial balloon dilations to adult aortic diameters. Early COA stenting produced measurable mid-term pathophysiologic cardiovascular consequences by 20 weeks compared with COA controls (with successful stent implantation and subsequent serial dilations). These findings support the need to understand long-term vascular remodeling and functional outcomes after early COA stent strategies before translating novel stent technologies to pediatric patients.

Gober LM, Stellon MA, Culver MA et al. · Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions · (2026) · View on PubMed ↗ · Free PDF ↗

Intraoperative Cardiac Events During Pediatric Cardiac Magnetic Resonance Imaging Under Anesthesia: A Retrospective Cohort Study.

This retrospective cohort study evaluated intraoperative cardiac events in children (≤18 years) with congenital heart disease undergoing cardiac MRI under anesthesia from 2013–2025. Using a recently proposed composite framework for intraoperative cardiovascular instability, it assessed the incidence and predictors of peri-procedural cardiovascular instability during a non-surgical imaging setting. The results are intended to improve peri-anesthesia risk stratification and monitoring strategies for pediatric CHD patients undergoing cardiac MRI.

Wingert T, Liang J, Feldman K et al. · Paediatric anaesthesia · (2026) · View on PubMed ↗ · Free PDF ↗

Unmasking subclinical cardiomyopathy: The role of cardiopulmonary exercise testing when screening genotype-positive phenotype negative relatives.

This single-centre case series evaluated whether cardiopulmonary exercise testing (CPET) can detect subclinical cardiomyopathy in gene-positive, phenotype-negative relatives from families with likely/definite pathogenic cardiomyopathy variants. Gene-positive relatives underwent extensive phenotyping (ECG, echocardiography, Holter monitoring, and cardiac MRI), and the study assessed CPET’s added value for unmasking early disease (full results truncated). If CPET improves detection beyond standard imaging/ECG in G+P− relatives, it could refine cascade screening and risk stratification for inherited cardiomyopathy.

Abela M, Scicluna J, Debattista J et al. · International journal of cardiology · (2026) · View on PubMed ↗

Multicenter comparison of hybrid and Norwood procedures in patients with Fontan circulation.

This multicenter registry study compared hybrid stage 1 palliation (HS1P) versus the Norwood operation for patients with Fontan circulation using the Fontan Outcomes Registry. After propensity score matching, the authors compared a composite outcome (including death, transplant listing, protein-losing enteropathy, plastic bronchitis, arrhythmias, and pulmonary artery reintervention) and cardiac magnetic resonance variables, with additional subgroup analyses by shunt type (Sano vs Blalock–Taussig) (results truncated). The work is clinically significant because it informs which surgical pathway may yield better outcomes for Fontan candidates.

Kobayashi K, Schiff M, Seese L et al. · The Journal of thoracic and cardiovascular surgery · (2026) · View on PubMed ↗ · Free PDF ↗

Valvular Heart Disease & Transcatheter Planning (MR/TPVR)

Successful repair of a rare submitral aneurysm with basal septal defect: a technique combining edge-to-edge repair and patch exclusion.

This case report described surgical management of a 44-year-old man with a rare submitral left ventricular aneurysm (SLVA) with a basal septal defect, using multimodality imaging including cardiac MRI to characterize a large aneurysm with thick mural thrombus and severe secondary mitral regurgitation. The key finding was successful repair combining edge-to-edge mitral repair with patch exclusion of the aneurysm. Clinically, the technique offers a practical operative strategy for a high-mortality condition where both aneurysm exclusion and mitral pathology must be addressed while preserving ventricular geometry.

Sawant G, Aironi B, Agarwal A et al. · Indian journal of thoracic and cardiovascular surgery · (2026) · View on PubMed ↗ · Free PDF ↗

An integrative approach to patient selection for mitral transcatheter edge-to-edge repair in secondary mitral regurgitation.

This review proposed an integrative patient-selection framework for mitral transcatheter edge-to-edge repair (M-TEER) in secondary mitral regurgitation (SMR) by combining randomized trial evidence, proportionality concepts, and multimodality imaging. It argues that differences in outcomes between MITRA-FR and COAPT are largely explained by echocardiographic selection and left-ventricular remodeling, implying that SMR severity should be interpreted relative to ventricular size and regurgitant context. The significance is a structured approach to identify SMR patients most likely to benefit from M-TEER and avoid under- or over-selection.

Brusosa M, Flores-Umanzor E, Horlick E · Current opinion in cardiology · (2026) · View on PubMed ↗

One Anatomy, Multiple Valve Choices: Interobserver Agreement in Selecting Transcatheter Pulmonary Valve.

This study assessed interobserver agreement among six experienced clinicians selecting transcatheter pulmonary valve replacement (TPVR) device type, size, and position using 60 3D patient-specific anatomies reconstructed from cardiac magnetic resonance (CMR). Observers showed variable agreement in valve type (self-expanding vs balloon-expandable vs surgical approach), sizing, and positioning, and the authors explored a framework to quantify and interpret consensus. The findings are important for standardizing TPVR planning and improving reproducibility of device selection across centers.

Pérez-Cualtán CE, Cabrales J, Garay F et al. · Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions · (2026) · View on PubMed ↗ · Free PDF ↗

Advances in artificial intelligence for the evaluation of mitral regurgitation.

This review summarized current evidence for artificial intelligence (AI) across the diagnostic pathway for mitral regurgitation (MR), spanning pre-imaging screening to advanced multimodality imaging. It found that AI tools such as digital stethoscopes and deep learning ECG models are promising for scalable enrichment and risk stratification but often function as adjuncts rather than standalone diagnostic systems. The review’s significance is guiding how AI should be integrated into MR workflows to reduce interobserver variability and improve efficiency while maintaining diagnostic accuracy.

Sanchez AA, Sadeghpour A, Asch FM · Current opinion in cardiology · (2026) · View on PubMed ↗

Mitral Regurgitation Assessment Using a Novel Automated Three-Dimensional Color-Flow Quantification: Comparison with Two-Dimensional Proximal Isovelocity Surface Area and Cardiac Magnetic Resonance.

This retrospective study evaluated a novel automated three-dimensional color-flow quantification tool (3D Auto CFQ) for mitral regurgitation (MR) severity and regurgitant volume in 185 patients with MR who underwent transesophageal echocardiography (TEE). Compared with two-dimensional proximal isovelocity surface area (2D PISA), 3D Auto CFQ provided feasible MR quantification with performance that was benchmarked against CMR-derived measures (as the reference standard). The results suggest that automated 3D TEE color-flow quantification could improve MR quantification accuracy by reducing 2D geometric assumptions and single-frame limitations.

Kim K, Lee SH, Lee HJ et al. · Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography · (2026) · View on PubMed ↗

Myocarditis & Inflammatory Cardiomyopathy

Feasibility of cardiac magnetic resonance for assessing atrioventricular block in acute myocarditis.

This retrospective single-center study evaluated atrioventricular block (AVB) severity in 105 acute myocarditis patients using cardiac magnetic resonance (CMR) functional and tissue parameters, comparing non-AVB, nonadvanced AVB, and advanced AVB groups. Patients with AVB—especially advanced AVB—showed worse CMR-derived functional/tissue characteristics and were more likely to experience adverse clinical outcomes. The results suggest CMR can improve risk stratification of AVB severity in acute myocarditis beyond clinical assessment alone.

Liao R, Qian Z, Yin F et al. · Clinical radiology · (2026) · View on PubMed ↗

Stratification of children with myocarditis using radiomics signatures in LGE cardiovascular MRI.

This study investigated whether radiomics signatures derived from late gadolinium enhancement (LGE) cardiovascular MRI can stratify pediatric myocarditis cases by quantifying LGE texture and location. Using radiomic feature extraction with attention to variability via resampling strategies and non-negative matrix factorization (NMF), the authors derived signatures intended to distinguish clinically heterogeneous myocarditis presentations. The approach aims to convert qualitative LGE assessment into quantitative biomarkers that could improve risk stratification and outcome prediction in children.

Laube AP, Huellebrand M, Ter-Minassian L et al. · Computer methods and programs in biomedicine · (2026) · View on PubMed ↗ · Free PDF ↗

Incidence and predictors of major arrhythmic events after acute myocarditis complicated by ventricular arrhythmias: A systematic review and meta-analysis.

This systematic review and meta-analysis quantified recurrence rates and predictors of major arrhythmic events (MAEs) after discharge in patients with acute myocarditis complicated by ventricular arrhythmias (sustained VAs). The authors searched PubMed, Web of Science, and Cochrane Library through December 2024 and used PROSPERO-registered methods (CRD420250594422), focusing on postdischarge VA recurrence and risk factors (full pooled results truncated). Identifying reliable predictors could guide ICD decision-making and post-discharge monitoring strategies in this high-risk myocarditis subgroup.

M’Rabet S, Kaboré EG, Rav-Acha M et al. · Heart rhythm · (2026) · View on PubMed ↗

Coronary Disease, Microvascular Ischemia & MINOCA Pathways

Viability testing for guiding revascularization in ischemic cardiomyopathy.

This review evaluated the clinical role of myocardial viability testing to guide revascularization decisions in ischemic cardiomyopathy in the context of contemporary revascularization strategies and guideline-directed medical therapy. It highlights that trials such as STICH and follow-up data show survival benefit from CABG that is not dependent on viability status, challenging the traditional viability paradigm. The scientific significance is a shift toward more selective or alternative decision frameworks for revascularization rather than relying on viability testing alone.

Li KY, Dhingra NK, Patel R et al. · Current opinion in cardiology · (2026) · View on PubMed ↗

Spatial proximity or vector orientation? Re-evaluating ECG interpretation in anterior myocardial infarction using cardiac magnetic resonance.

This prospective study tested how ECG interpretation methods for anterior myocardial infarction (MI)—anatomical lead proximity versus ST-segment vector orientation—match CMR-defined myocardial injury distribution in 105 patients scanned 3–7 days after presentation. The key finding was that CMR (using late gadolinium enhancement to map injury) provided a direct reference that re-evaluated the validity of conventional ECG localization approaches. This is significant because it may improve the accuracy of ECG-based infarct localization/extent assessment when CMR is used as the injury ground truth.

Aslanger EK, Aggül B, İnan D et al. · Journal of electrocardiology · (2026) · 1 citations · View on PubMed ↗

Feasibility and Yield of a Diagnostic Protocol for Myocardial Infarction With Nonobstructive Coronary Arteries.

This prospective multicenter cohort study evaluated the feasibility and diagnostic yield of a structured MINOCA (myocardial infarction with nonobstructive coronary arteries) diagnostic protocol beyond initial invasive coronary angiography (ICA) in MINOCA patients enrolled from December 2020 to June 2024. The protocol used a stepwise approach with ad hoc optical coherence tomography (OCT) for culprit lesion identification after ICA, aiming to determine the final underlying diagnosis. Clinically, it supports a practical imaging-guided pathway to increase diagnostic completeness in MINOCA despite real-world constraints.

Nishimiya K, Yosofi B, Dimitriu-Leen AC et al. · The American journal of cardiology · (2026) · View on PubMed ↗ · Free PDF ↗

Cardiac Imaging Methods & Acquisition Optimization

Free-Breathing Dynamic, Regularized, Adaptive Cluster Optimization (DRACO) Cine Cardiac MRI in Atrial Fibrillation.

This prospective study evaluated a free-breathing adaptation of DRACO (Dynamic Regularized Adaptive Cluster Optimization) cine cardiac MRI in atrial fibrillation (AF) patients. In 20 AF patients and 10 sinus rhythm controls at 3.0 T using bSSFP cine with ECG-gated segmented acquisition, the tailored DRACO approach aimed to simultaneously manage cardiac and respiratory motion to produce high-quality quantifiable cine images. The significance is enabling reliable cine MRI in AF without breath-holding, potentially improving assessment of cardiac function in arrhythmia patients.

Ming Z, Pogosyan A, Dong X et al. · Journal of magnetic resonance imaging : JMRI · (2026) · 1 citations · View on PubMed ↗ · Free PDF ↗

Optimized Reduced Field of View and Fat Suppression Methods for Interleaved Multislice In Vivo Cardiac Diffusion Tensor Imaging.

This MRI methods study optimized reduced field-of-view (FOV) and fat-suppression strategies for interleaved multislice in vivo cardiac diffusion tensor imaging (cDTI). Using two-slice motion-compensated spin-echo datasets from 20 healthy volunteers, the authors compared reduced PE FOV approaches (including 2DRF pulse and flip-angle schemes such as 180°/90° in the phase-encode direction and a proposed flip-back sequence) to improve signal-to-noise ratio and reduce artifacts (results truncated). Improved cDTI acquisition efficiency and artifact control could enhance clinical feasibility of cardiac microstructure mapping.

Luo Y, Ferreira PF, Wen K et al. · Magnetic resonance in medicine · (2026) · 1 citations · View on PubMed ↗ · Free PDF ↗

Evaluation of Third-Order Motion-Compensated Cardiac Diffusion Tensor Imaging Across Cardiac Phases Using an Ultra-High-Performance Clinical Scanner.

This study evaluated a third-order motion-compensated spin echo sequence (M3-MCSE) for cardiac diffusion tensor imaging (cDTI) across cardiac phases on a 3T clinical scanner with ultra-high-performance gradients. In 20 healthy subjects, cDTI was acquired at peak systole and diastasis using STEAM, second-order MCSE (M2-MCSE), and M3-MCSE, and image quality and diffusion metrics were compared; five additional subjects had diffusion-weighted images at multiple diastolic trigger delays to assess motion-induced signal loss (results truncated). If M3-MCSE better preserves diffusion signal across the cardiac cycle, it could improve robustness of cDTI for clinical and research use.

Wen K, Ferreira PF, Di Biase Oemick A et al. · Magnetic resonance in medicine · (2026) · View on PubMed ↗ · Free PDF ↗

Thromboembolism/Embolization & Vascular Shunts

Impact of Systemic-to-Pulmonary Artery Shunt Embolization on Right Heart Hemodynamics in Patients with Bronchiectasis.

This study evaluated right heart hemodynamic changes in 20 patients with bronchiectasis complicated by systemic-to-pulmonary artery shunts (SPS) undergoing SPS embolization, using right heart catheterization and (in some patients) cardiac MRI before and 24–48 hours after the procedure. Embolization improved right heart hemodynamics, including stroke volume, cardiac index/output, and pulmonary artery pressures, alongside changes in shunt oxygen saturation. These early post-embolization physiologic improvements support SPS embolization as a targeted intervention to reduce right-sided volume/pressure burden in bronchiectasis-associated shunt disease.

Wu H, Jiang F, Guo L et al. · Journal of vascular and interventional radiology : JVIR · (2026) · View on PubMed ↗

Exercise/Activity & Cardiovascular Outcomes

Subclinical Origins of Cardiometabolic Risk in Indian Adolescents: A Cross-Sectional Study.

This cross-sectional study measured anthropometry, hepatic fat, and cardiometabolic risk factors in apparently healthy Indian adolescents aged 11–16 years. Using 3.0T MRI proton density fat fraction (PDFF) for hepatic fat and DXA for whole-body fat, the authors found that cardiometabolic risk factors were present in a substantial minority of participants (at least one CMR factor in 32.5%, with further associations truncated in the abstract). These findings suggest that subclinical cardiometabolic risk can begin in adolescence and may be detectable using MRI/DXA-based body-fat phenotyping in Indian youth.

Hegde SG, Kankara SR, Raj JM et al. · Indian pediatrics · (2026) · View on PubMed ↗

Trauma & Hypothermia Outcomes

Hypothermia on trauma center arrival has a much greater impact on outcomes at the extremes of age.

This retrospective cohort study analyzed trauma patients in the Trauma Quality Improvement Program (2020–2023) with valid arrival temperatures, stratifying outcomes by age (pediatric vs geriatric vs other ages) and by hypothermia severity (normothermia 36–38°C, mild 35–35.9°C, severe <35°C). Hypothermia at trauma center arrival showed a disproportionately greater association with worse outcomes at the extremes of age, with the strongest impact observed in pediatric and geriatric patients. These findings support prioritizing rapid temperature control and hypothermia prevention during initial trauma resuscitation, especially for very young and older patients.

Crosier CJ, Rempson CM, Green A et al. · The journal of trauma and acute care surgery · (2026) · View on PubMed ↗

Generated automatically on September 04, 2026. Covers PubMed articles published August 28, 2026 – September 04, 2026. Summaries are AI-generated; always consult the original publication for clinical or research decisions.

← All Cardiac MRI Digests