What's New in Cardiac MRI? — September 05, 2026

AI-summarised digest of 91 PubMed articles on Cardiac MRI published in the last 7 days.

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Arrhythmias and electrophysiology (including device/ECG risk markers) Cardio-oncology and cancer therapy–related cardiovascular toxicity Congenital heart disease and pediatric cardiac imaging/hemodynamics Cardiac MRI/CT biomarkers for prognosis and risk stratification Myocardial injury after ischemia/infarction (CMR tissue characterization) Cardiac imaging AI and automated analysis (segmentation, motion, radiomics) Cardiac sarcoidosis, pericardial disease, and systemic inflammatory causes Non-medical imaging/biomarker methods beyond cardiology (e.g., atmospheric science, dialysis causality) Cardiovascular complications of systemic diseases (autoimmune, genetic metabolic, dystrophinopathies) Cardiovascular imaging in pregnancy and special populations Cardiac MRI for cardiomyopathies (HCM and other genetic/structural diseases) Heart failure and precision/AI-guided intervention planning Exercise, lifestyle, and functional testing as cardiovascular risk modifiers Non-cardiac oncology (imaging endpoints and cancer biology) Valvular heart disease and transcatheter repair planning

What’s New in Cardiac MRI?

September 05, 2026 · 91 articles · 15 research themes · covering August 29, 2026 – September 05, 2026

Overview

Across this week’s set, a dominant theme is the move toward more precise, imaging-derived risk stratification—especially using advanced cardiac MRI (CMR) tissue characterization and quantitative functional metrics. Multiple studies show that “metabolic” or “tissue” signals after therapy (e.g., FDG PET/CT metabolic tumor volume in colorectal liver metastases; CMR-derived ECV in HCM; CMR stress perfusion in younger patients; CMR markers in myocarditis, AV block, and HFmrEF) can outperform conventional clinical variables for predicting outcomes. In parallel, several works emphasize that CMR can serve as a noninvasive surrogate for invasive procedures (e.g., pediatric heart-transplant rejection monitoring) and can refine surveillance in populations where standard assessment is limited.

A second major thread is the rapid expansion of AI and automated imaging pipelines to improve reproducibility and scalability. Studies and reviews cover automated scar detection from CT with CMR as reference, deep-learning keyframe detection for cine CMR, motion tracking frameworks, and radiomics/segmentation approaches for cardiac masses and myocarditis subtyping. Together, these efforts aim to reduce interobserver variability, shorten analysis time, and enable broader deployment of advanced imaging biomarkers in routine care.

Finally, the digest highlights how advanced imaging is being integrated into complex clinical decision-making across diverse cardiovascular contexts: electrophysiology workflows for post-infarct VT, selection frameworks for transcatheter mitral repair, and structured diagnostic pathways for MINOCA using OCT. Case reports and reviews further broaden the clinical lens—covering rare but high-stakes etiologies (e.g., constrictive pericarditis from tuberculosis/Erdheim-Chester, systemic sclerosis–associated fulminant myocarditis, and unusual cardiac tumors), and underscoring the value of multimodality imaging when presentations are atypical or syndromic.

Arrhythmias and electrophysiology (including device/ECG risk markers)

Integration of Functional Mapping and Image-Guided Structural Information in Ventricular Tachycardia Ablation - Sense2 Mapping.

This prospective multicenter propensity-matched registry studied 166 post-infarct ventricular tachycardia (VT) patients undergoing Sense2 ventricular tachycardia ablation, integrating cardiac MRI/CT-derived scar data into functional mapping. Compared with conventional ablation strategies, incorporating MRI/CT scar information into the functional mapping workflow reduced protracted mapping/procedure time and improved ablation targeting and clinical outcomes. The approach supports a more efficient, image-guided substrate mapping workflow for post-infarct VT ablation in routine practice.

Papageorgiou N, Bangash F, Ladopoulou D et al. · Heart rhythm · (2026) · View on PubMed ↗ · Free PDF ↗

Transient Pneumopericardium During Implantation of an Extravascular Implantable Cardioverter-Defibrillator.

This JACC Case Reports report describes a 48-year-old man with ischemic cardiomyopathy (EF 14%) who underwent extravascular implantable cardioverter-defibrillator (EV-ICD) implantation for secondary prevention after monomorphic VT arrest. Substernal tunneling caused pericardial puncture leading to transient pneumopericardium, which resolved after lead repositioning and completion of intraoperative testing. The case highlights a specific procedural complication unique to the substernal EV-ICD route and informs risk awareness during implantation.

Ollitrault P, Pellissier A, Ferchaud V et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗

Hidden in Plain Sight: Electromechanical Window Negativity in Congenital Long QT Syndrome.

This report studied electromechanical window (EMW) negativity as a risk marker in a 19-year-old woman with KCNH2-related congenital long QT syndrome (LQTS) who had recurrent syncope triggered by abrupt auditory stimuli. Despite normal cardiac MRI and standard echocardiography, ambulatory monitoring captured self-terminating torsades de pointes up to 273 beats/min, and retrospective analysis identified EMW negativity within routine echocardiographic imaging. Scientifically and clinically, it suggests EMW negativity can refine arrhythmic risk stratification beyond genotype and QTc duration in KCNH2 LQTS.

Paterson T, Sanders R, Pooranachandran V · Clinical case reports · (2026) · View on PubMed ↗ · Free PDF ↗

Exercise-Induced Ventricular Tachycardia Unmasking High-Risk Anomalous Right Coronary Artery in an Adult.

This JACC Case Reports article studied exercise-induced ventricular tachycardia in a 43-year-old adult that unmasked a high-risk anomalous right coronary artery (AAOCA). Exercise stress testing showed frequent ventricular ectopy progressing to nonsustained VT during recovery, and coronary CT angiography identified an anomalous right coronary artery arising from the left sino–aortic region. The case is clinically important because it supports considering AAOCA in adults with exertional arrhythmias and using CCTA to define anatomy for management decisions.

Eisa A, Rashwan R, Aldarab’ah FM et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗

[Interarterial anomalous right coronary artery in a competitive athlete: case report].

This case report studied a 37-year-old competitive endurance athlete undergoing pre-participation screening for congenital coronary anomalies, specifically anomalous right coronary artery origin from the left sinus of Valsalva with an interarterial course and intramural segment. Coronary computed tomography angiography identified high-risk anatomy consistent with increased risk of myocardial ischemia and sudden cardiac death under exercise-related hemodynamic stress. The finding is significant because it supports using CT angiography to stratify dynamic, anatomy-exercise risk in athletes and inform management decisions.

Lodi E, Tardini L, Poli ML et al. · Giornale italiano di cardiologia (2006) · (2026) · View on PubMed ↗

Blood-nulled late gadolinium enhancement increases sensitivity for subtle basal myocardial scar in mitral valve prolapse with annular disjunction.

This case report studied whether blood-nulled late gadolinium enhancement (LGE) CMR can detect subtle basal myocardial scar in a 67-year-old woman with mitral valve prolapse (MVP) and mitral annular disjunction (MAD) that was not clearly visible on conventional bright-blood LGE. It found that blood-nulled LGE increased sensitivity for a small (3-mm) posterior MAD–associated basal inferolateral scar, aligning with arrhythmia findings from 24-hour Holter monitoring. The clinical significance is improved CMR detection of arrhythmogenic fibrosis in MVP/MAD, potentially strengthening risk stratification for ventricular arrhythmias.

Avakian A, Umair M · Radiology case reports · (2026) · View on PubMed ↗ · Free PDF ↗

Cardio-oncology and cancer therapy–related cardiovascular toxicity

Circulating Biomarkers in Cardio-Oncology: Prediction and Prognostication.

This narrative review summarized evidence on circulating biomarkers used for prediction and prognostication of cancer therapy–related cardiovascular toxicity in cardio-oncology. Cardiac troponins and natriuretic peptides were identified as the most consistently prognostic biomarkers, while biomarker-guided treatment strategies remain limited by variable performance and lack of definitive outcome data. Clinically, the review highlights which blood tests are most useful for risk stratification and where evidence gaps remain for changing therapy based on biomarker results.

Kim J, Lee B, White A et al. · Current cardiology reports · (2026) · View on PubMed ↗ · Free PDF ↗

Survival of patients with complete metabolic response on [18F]FDG PET/CT after chemotherapy prior to transplantation for colorectal liver metastases.

This study evaluated 45 patients with colorectal liver metastases undergoing transplantation after chemotherapy, comparing outcomes in those with complete metabolic response (CMR; [18F]FDG PET/CT MTV=0) versus patients with low or high metabolic tumor volume (MTV) derived from pre-transplant [18F]FDG PET/CT and diagnostic CT (SECA 1 and 2 cohorts). Patients with CMR on [18F]FDG PET/CT showed improved disease-free survival and overall survival compared with groups with non-zero MTV, indicating that PET/CT metabolic activity after chemotherapy is a strong prognostic marker. Clinically, using [18F]FDG PET/CT–defined CMR (MTV=0) can help risk-stratify CRLM patients for transplantation and potentially guide post-transplant surveillance and treatment decisions.

Stern NM, Dueland S, Line PD et al. · Scandinavian journal of surgery : SJS : official organ for the Finnish Surgical Society and the Scandinavian Surgical Society · (2026) · 1 citations · View on PubMed ↗ · Free PDF ↗

Congenital heart disease and pediatric cardiac imaging/hemodynamics

Value of the Newly Designed Major and Minor Checklists in Diagnosis of Congenital Cardiovascular Disease and Associated Malformation: New Era of Fetal Cardiac MRI.

This study evaluated a newly designed major/minor checklist system for interpreting fetal cardiac magnetic resonance imaging (FCMRI) by correlating structured FCMRI interpretations with postnatal echocardiographic outcomes in fetuses with suspected congenital cardiovascular disease and malformations. The structured checklist improved diagnostic reliability/consistency of FCMRI interpretation compared with unstructured assessment. The checklist framework could standardize fetal CMR reporting and improve prenatal diagnostic accuracy when fetal echocardiography is limited (e.g., maternal obesity or acoustic shadowing).

Hassan HGEMA, Ragheb SR, Elyasaki AM et al. · Academic radiology · (2026) · View on PubMed ↗

Early-Diastolic Right Ventricle-Pulmonary Artery Pressure Gradient by Doppler Echocardiography to Guide Cardiac Magnetic Resonance Assessment of Pulmonary Regurgitation after Right Ventricular Outflow Tract Reconstruction.

This retrospective study evaluated whether an echocardiographic early-diastolic right ventricle–pulmonary artery pressure gradient (Echo-EaDPG), calculated from early-diastolic peak pulmonary regurgitation velocity (ΔP = 4v2), can guide cardiac magnetic resonance (CMR) assessment of pulmonary regurgitation after right ventricular outflow tract (RVOT) reconstruction in pediatric patients with repaired tetralogy of Fallot or related conditions. The key finding was that Echo-EaDPG could serve as a practical complementary hemodynamic marker to inform when and how CMR should be used for quantifying pulmonary regurgitation. Scientifically and clinically, it provides a feasible echocardiographic surrogate for PR severity in follow-up settings where CMR is not routinely available.

Kawamura J, Ueno K, Shimozono T et al. · Echocardiography (Mount Kisco, N.Y.) · (2026) · View on PubMed ↗ · Free PDF ↗

Advanced Cardiac Imaging Techniques for Detection of Myocardial Ischemia in Children with Coronary Artery Abnormalities.

This review studied advanced cardiac imaging approaches for detecting myocardial ischemia in children with coronary artery abnormalities, including post–Kawasaki vasculopathy, transplant-related allograft vasculopathy, congenital coronary anomalies (e.g., anomalous aortic origin of a coronary artery), and post-surgical coronary reimplantation complications. The key finding (truncated) was that pediatric ischemia detection requires specialized imaging strategies because symptoms are often absent or atypical and standard screening (e.g., resting ECG) is limited. Scientifically and clinically, it supports selecting appropriate imaging modalities to diagnose ischemia and prevent ventricular dysfunction and sudden cardiac death in high-risk pediatric coronary conditions.

Jin JB, Williams JL, Wang SM et al. · Cardiology and therapy · (2026) · View on PubMed ↗ · Free PDF ↗

Non-invasive detection of acute cell-mediated graft rejection in paediatric heart transplant recipients: The role of cardiovascular magnetic resonance.

This prospective study tested whether multiparametric cardiovascular magnetic resonance (CMR) can non-invasively detect acute cell-mediated graft rejection in pediatric heart transplant recipients, using endomyocardial biopsy (EMB) and right heart catheterization as reference standards. The key finding was that multiparametric CMR could identify rejection status and that textural features derived from parametric maps differed between rejection and non-rejection cases. Clinically, this supports CMR as a potential noninvasive alternative to EMB for monitoring rejection in children after heart transplantation.

Gesuete V, Ragni L, Niro F et al. · International journal of cardiology. Congenital heart disease · (2026) · View on PubMed ↗ · Free PDF ↗

One Anatomy, Multiple Valve Choices: Interobserver Agreement in Selecting Transcatheter Pulmonary Valve.

This study assessed interobserver agreement in selecting transcatheter pulmonary valve replacement (TPVR) device type, size, and position using 3D patient-specific anatomies reconstructed from cardiac magnetic resonance (CMR) images. Six experienced observers independently evaluated 60 pediatric and adult anatomies, and the study quantified agreement across valve choices (self-expanding, balloon-expandable, and surgical approach) and positioning. The significance is that it provides evidence on the reproducibility of TPVR planning workflows, which is important for standardizing device selection and improving procedural consistency.

Pérez-Cualtán CE, Cabrales J, Garay F et al. · Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions · (2026) · View on PubMed ↗ · Free PDF ↗

Intraoperative Cardiac Events During Pediatric Cardiac Magnetic Resonance Imaging Under Anesthesia: A Retrospective Cohort Study.

This single-center retrospective cohort study analyzed pediatric patients (≤18 years) with congenital heart disease (CHD) undergoing cardiac magnetic resonance imaging (MRI) under anesthesia from 2013–2025 to determine the incidence and predictors of intraoperative cardiac events using a composite framework of intraoperative cardiovascular instability. The key finding was that intraoperative cardiac events occurred during pediatric cardiac MRI under anesthesia and could be predicted by patient/procedural factors captured in the instability framework. Clinically, this helps refine peri-anesthesia monitoring and risk stratification for children undergoing non-surgical but physiologically vulnerable imaging procedures.

Wingert T, Liang J, Feldman K et al. · Paediatric anaesthesia · (2026) · View on PubMed ↗ · Free PDF ↗

Impact of Systemic-to-Pulmonary Artery Shunt Embolization on Right Heart Hemodynamics in Patients with Bronchiectasis.

This interventional study enrolled patients with bronchiectasis complicated by systemic-to-pulmonary artery shunts (SPS) and assessed right heart hemodynamics using right heart catheterization (and cardiac MR in those who tolerated it) before and within 24–48 hours after SPS embolization. The key finding was that SPS embolization improved right heart hemodynamic parameters, including measures such as stroke volume, cardiac index/output, and pulmonary pressures, shortly after the procedure. This supports SPS embolization as a hemodynamically beneficial treatment strategy in bronchiectasis-associated shunt physiology.

Wu H, Jiang F, Guo L et al. · Journal of vascular and interventional radiology : JVIR · (2026) · View on PubMed ↗

Multicenter comparison of hybrid and Norwood procedures in patients with Fontan circulation.

This multicenter registry study compared hybrid stage 1 palliation (HS1P) versus the Norwood procedure in patients with Fontan circulation using propensity score matching. The primary composite outcome (including death, transplant listing, protein-losing enteropathy, plastic bronchitis, arrhythmias, or pulmonary artery reintervention) and cardiac magnetic resonance variables were compared between strategies, with secondary analyses examining HS1P shunt type (Sano vs Blalock–Taussig). The results inform surgical decision-making for initial palliation strategies in Fontan candidates and highlight the role of CMR variables in outcome assessment.

Kobayashi K, Schiff M, Seese L et al. · The Journal of thoracic and cardiovascular surgery · (2026) · View on PubMed ↗ · Free PDF ↗

Cardiac MRI/CT biomarkers for prognosis and risk stratification

Prospective evaluation of real-world safety, symptoms improvement and adherence to mavacamten among Iranian patients with hypertrophic obstructive cardiomyopathy (PERSIA-HOCM): protocol of a multicentre observational study.

This multicentre observational protocol (PERSIA-HOCM) is designed to prospectively evaluate real-world safety, symptom improvement, and adherence to mavacamten in Iranian patients with hypertrophic obstructive cardiomyopathy (HOCM). The study will generate prospective effectiveness and tolerability data outside randomized trials, focusing on routine clinical use in a non-Western population. The results are intended to inform clinicians about mavacamten’s real-world risk–benefit profile and adherence feasibility in HOCM care.

Ghaseminejad-Raeini A, Karimi MA, Shirinezhad A et al. · BMJ open · (2026) · View on PubMed ↗ · Free PDF ↗

Vasodilator stress perfusion CMR for outcome prediction in patients under 45 years with suspected CAD.

This retrospective analysis of a prospective multicenter registry assessed long-term prognostic value of vasodilator stress cardiovascular magnetic resonance (CMR) for all-cause mortality in patients younger than 45 years with suspected coronary artery disease. Vasodilator stress CMR findings were associated with subsequent mortality risk over extended follow-up. The study extends CMR risk stratification evidence to younger patients, supporting stress CMR as a tool for outcome prediction in this under-studied age group.

Vesvrotte ER, Garot J, Duhamel S et al. · Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · (2026) · View on PubMed ↗ · Free PDF ↗

Psychosocial Stress-Induced Takotsubo Syndrome in a Male Patient: Breaking the Stereotype.

This case report describes a 48-year-old man who developed Takotsubo syndrome (TTS) after psychosocial stress, an atypical presentation given that TTS more commonly affects postmenopausal women. Cardiac MRI showed dynamic left ventricular outflow tract obstruction and four discrete apical thrombi, and the patient recovered fully with β-blockade and anticoagulation. The case broadens clinical awareness that severe TTS complications and thrombus can occur even with nontraditional triggers and in male patients.

Beesley H, Soroa M, Lerakis S et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗

Angiomatoid Fibrous Histiocytoma: An Exceptionally Rare Pulmonary Artery Tumor Presenting as an Asymptomatic Heart Murmur.

This case report studied an exceptionally rare angiomatoid fibrous histiocytoma (AFH) arising as a primary pulmonary artery tumor in a 28-year-old man with prior stage 3 Burkitt lymphoma in remission who presented with a new systolic heart murmur. Multimodality imaging (transthoracic echocardiography, cardiac MRI, and PET-CT) identified a 1.9 cm hyperintense mass attached to the pulmonic valve and main pulmonary artery, leading to surgical resection of the main pulmonary artery and pulmonic valve. Clinically, it highlights AFH as a diagnostic consideration for pulmonary artery tumors presenting with murmur and emphasizes the value of advanced imaging to guide definitive management.

Jafary Z, Rana S, Vaughan M et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗

Optimal Strain Combinations for Prognostic Prediction in Pulmonary Arterial Hypertension.

This Circulation: Heart Failure study analyzed prognostic performance of combinations of myocardial strain parameters in patients with pulmonary arterial hypertension (PAH) prospectively recruited from June 2013 to June 2024. Using elastic net Cox regression and stepwise Cox regression with AIC-based selection, the study identified an optimal set of strain measures (including left ventricular global longitudinal strain, right ventricular GLS/free-wall longitudinal strain, and right atrial phasic strain) that best predicted all-cause mortality and a composite endpoint. The findings are significant because they provide a data-driven approach to selecting echocardiographic strain features for risk stratification in PAH.

Guo J, Leng S, He J et al. · Circulation. Heart failure · (2026) · View on PubMed ↗

Refractory Postcardiotomy Right Ventricular Failure Revealing Massive Right Ventricular Lipomatous Replacement: Autopsy-Imaging Correlation.

This case report studied refractory post-cardiotomy right ventricular (RV) failure in a 76-year-old woman and used autopsy-imaging correlation to characterize massive RV lipomatous replacement. Despite preoperative echocardiography and cardiac MRI showing preserved biventricular function without abnormal fat on standard sequences, the patient developed refractory RV failure after cardiopulmonary bypass requiring escalating support including venoarterial extracorporeal membrane oxygenation. Scientifically, it highlights the diagnostic challenge of distinguishing benign RV fat from arrhythmogenic right ventricular cardiomyopathy (ARVC) and shows how postmortem correlation can clarify imaging limitations.

Landín P, Plateros S, Campelos P et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗

Cardiovascular magnetic resonance-based arrhythmogenic substrate assessment improves sudden cardiac death risk stratification in heart failure with mildly reduced ejection fraction: a multicenter retrospective observational study.

This multicenter retrospective observational study assessed whether cardiovascular magnetic resonance (CMR) markers—late gadolinium enhancement (LGE) and T1 mapping—improve sudden cardiac death (SCD) risk stratification in 1855 patients with heart failure with mildly reduced ejection fraction (HFmrEF), using a development cohort (n=1417) and external validation cohort (n=438). The key finding was that CMR-based arrhythmogenic substrate assessment enhanced SCD prediction beyond standard approaches. Clinically, it provides a more accurate risk stratification algorithm to guide preventive management in HFmrEF patients.

Wang W, Zhu R, Gao Y et al. · The Lancet regional health. Western Pacific · (2026) · View on PubMed ↗ · Free PDF ↗

A cross-sectional online survey evaluating how anaesthesiologists view cardiovascular magnetic resonance imaging reports as a tool for perioperative risk evaluation.

This cross-sectional online survey studied anaesthesiologists’ perceptions and use of cardiovascular magnetic resonance (CMR) reports for perioperative risk evaluation. The key finding (truncated) was how frequently and in what ways clinicians incorporate preexisting CMR findings into perioperative decision-making. The significance is that it informs how CMR results are translated into practice and identifies gaps in understanding that could improve perioperative risk stratification.

Fischer K, Harms R, Fini JN et al. · BJA open · (2026) · View on PubMed ↗ · Free PDF ↗

Successful repair of a rare submitral aneurysm with basal septal defect: a technique combining edge-to-edge repair and patch exclusion.

This case report studied a 44-year-old man with syncope and acute heart failure due to a rare submitral left ventricular aneurysm (SLVA) with a basal septal defect, focusing on surgical technique. Cardiac MRI identified a large basal septal LV aneurysm with thick mural thrombus and severe secondary mitral regurgitation, and the key procedural finding (truncated) was successful repair using a combined edge-to-edge mitral repair plus patch exclusion of the aneurysm. The clinical significance is that this hybrid approach may reduce risks such as rupture and systemic embolism while preserving ventricular geometry in complex SLVA anatomy.

Sawant G, Aironi B, Agarwal A et al. · Indian journal of thoracic and cardiovascular surgery · (2026) · View on PubMed ↗ · Free PDF ↗

Integrated left ventricular mass and left atrial function for prediction of cardiovascular outcomes: the Multi-Ethnic Study of Atherosclerosis.

This study evaluated whether a cardiac magnetic resonance (CMR)-derived left ventricular (LV) mass-to-left atrial (LA) strain ratio predicts cardiovascular outcomes in participants of the Multi-Ethnic Study of Atherosclerosis. The key finding was that the LV mass/LA strain imbalance (indexed end-diastolic LV mass divided by peak LA strain) identified early atrioventricular mechanical uncoupling and was associated with subsequent cardiovascular events. Clinically, this CMR-derived coupling metric may enable earlier risk stratification before overt structural atrial or ventricular disease.

Salameh E, Hoballah M, Ebrahimihoor E et al. · American journal of physiology. Heart and circulatory physiology · (2026) · View on PubMed ↗

Feasibility of cardiac magnetic resonance for assessing atrioventricular block in acute myocarditis.

This retrospective single-center study evaluated whether cardiac magnetic resonance (CMR) can assess atrioventricular block (AVB) severity in patients with acute myocarditis (AM). The key finding was that CMR functional and tissue parameters differed between non-AVB, nonadvanced AVB, and advanced AVB groups and were associated with adverse clinical outcomes including death, heart failure decompensation requiring readmission, and need for implantable cardioverter-defibrillator or cardiac resynchronisation therapy. The significance is that CMR may provide a noninvasive way to phenotype AVB severity and risk in acute myocarditis.

Liao R, Qian Z, Yin F et al. · Clinical radiology · (2026) · View on PubMed ↗

Cost-effectiveness of imaging modalities in coronary heart disease: A comprehensive review.

This comprehensive review evaluated the cost-effectiveness of imaging modalities used in coronary heart disease (CHD), focusing on myocardial perfusion imaging (MPI) with SPECT and PET. The key finding was that economic evaluations in CHD emphasize the need to match the imaging modality to clinical context while accounting for differences in performance, downstream testing, and healthcare costs as technologies evolve. The significance is that the review provides decision-relevant guidance for selecting CHD imaging strategies that balance diagnostic value with cost.

Milan E, Giubbini R, Vitola J et al. · Seminars in nuclear medicine · (2026) · 1 citations · View on PubMed ↗

Incremental prognostic value of cardiac magnetic resonance beyond biomarker staging in transthyretin cardiac amyloidosis.

This multicentre retrospective study evaluated whether adding CMR parameters to National Amyloidosis Centre (NAC) serum biomarker staging improves prognostic prediction in 266 patients with transthyretin cardiac amyloidosis (ATTR-CA). Using Cox regression for time to death, it found that CMR provided incremental prognostic value beyond NAC stage and could help guide evaluation for advanced heart failure therapies and emerging disease-modifying treatments. The significance is that CMR may refine staging and treatment selection in ATTR-CA beyond biomarker-only risk models.

Chiou T, Minga I, Subashchandran V et al. · European heart journal. Cardiovascular Imaging · (2026) · 1 citations · View on PubMed ↗

Spatial proximity or vector orientation? Re-evaluating ECG interpretation in anterior myocardial infarction using cardiac magnetic resonance.

This prospective study examined how ECG interpretation methods for anterior myocardial infarction (MI)—based on anatomical lead proximity versus vector orientation of ST-segment deviation—match CMR-defined myocardial injury. In 105 patients imaged by CMR 3–7 days after presentation, it re-evaluated conventional ECG localization categories and simplified ST-axis orientation against late gadolinium enhancement (LGE) injury distribution. The significance is that it tests the validity of ECG localization assumptions against direct imaging, which could improve accuracy of infarct localization and assessment of injury extent.

Aslanger EK, Aggül B, İnan D et al. · Journal of electrocardiology · (2026) · 1 citations · View on PubMed ↗

Long-term prognostic value of stress cardiovascular magnetic resonance in patients with hypertension without known coronary artery disease.

This longitudinal cohort study followed consecutive patients with hypertension without known coronary artery disease who underwent vasodilator stress cardiovascular magnetic resonance (CMR) from December 2008 to January 2022 to assess long-term prognostic value for major adverse cardiovascular events (MACE). Stress perfusion CMR findings were associated with subsequent MACE risk during follow-up, demonstrating prognostic utility in this screening population. Scientifically and clinically, the results support using vasodilator stress CMR to risk-stratify hypertensive patients without known CAD for earlier detection of occult coronary disease.

Houssany-Pissot S, Garot J, Duhamel S et al. · European heart journal. Cardiovascular Imaging · (2026) · 1 citations · View on PubMed ↗

AngioVac aspiration as a combined diagnostic and therapeutic strategy for an indeterminate right atrial mass in a patient with malignancy.

This radiology case report described a woman with primary mediastinal large B-cell lymphoma and an indeterminate right atrial mass where thrombus versus malignant involvement was uncertain on transthoracic echocardiography (TTE), transesophageal echocardiography (TEE), and cardiac MRI. The key finding was that catheter-directed aspiration using the AngioVac system enabled significant debulking and successful tissue retrieval, resolving the diagnostic uncertainty while avoiding high-risk surgery. Clinically, it supports AngioVac as a combined diagnostic-therapeutic option for right atrial masses in patients with malignancy when surgical biopsy is prohibitive.

Abumuhfouz M, Sena A, Suleiman S et al. · Radiology case reports · (2026) · View on PubMed ↗ · Free PDF ↗

Cardiac lipoma of the right atrial appendage: Multimodality imaging of a rare tumor at an uncommon site.

This radiology case report described a 60-year-old woman in whom a small, mobile fat-containing mass in the right atrial appendage (RAA) was incidentally discovered on computed tomography pulmonary angiography during evaluation for acute pulmonary embolism. The key finding was that cardiac magnetic resonance imaging confirmed imaging features consistent with a benign cardiac lipoma at an uncommon RAA site. The clinical significance is heightened awareness that RAA lipomas can mimic other intracardiac masses and may be detected incidentally during thromboembolic workups.

Kosum P, Tumkosit M, Jarutasnangkul L et al. · Radiology case reports · (2026) · 1 citations · View on PubMed ↗ · Free PDF ↗

Myocardial injury after ischemia/infarction (CMR tissue characterization)

AI-Powered Detection of Left Ventricular Myocardial Scar from Dual-Sequence CT: Global and Segmental Prediction Validated by CMR.

This single-center retrospective study evaluated whether intramyocardial hemorrhage (IMH) quantified on conventional T2-weighted (T2W) CMR improves risk stratification in 453 reperfused ST-elevation myocardial infarction (STEMI) patients. IMH defined as a hypointense core within edema on T2W imaging (expressed as % left ventricular mass) predicted a composite of all-cause death and heart failure hospitalization. The findings suggest a more accessible alternative to T2* mapping for prognostic assessment of reperfusion injury in STEMI.

Lu R, Yang T, Li M et al. · Journal of imaging informatics in medicine · (2026) · View on PubMed ↗ · Free PDF ↗

Angiography-Based Index of Microcirculatory Resistance in Assessing the MVO and Infarct Size in STEMI Patients.

This randomized study evaluated an angiography-based index of microcirculatory resistance (angio-IMR) for assessing microvascular obstruction (MVO) and infarct size (IS) in 123 ST-segment elevation myocardial infarction (STEMI) patients undergoing percutaneous coronary intervention (PCI), comparing pre-PCI thrombolysis with 5 mg intravenous recombinant staphylokinase (r-SAK) versus normal saline (NS). The key finding was the relationship of angio-IMR with CMR-detected MVO and infarct size, and how thrombolysis with r-SAK influenced post-PCI angio-IMR. Clinically, angio-IMR may improve physiologic risk assessment of microvascular injury after STEMI and help interpret the impact of thrombolytic strategy on downstream myocardial damage.

Wu T, Zhang X, Li C et al. · Clinical cardiology · (2026) · View on PubMed ↗ · Free PDF ↗

Sequential Changes in Right Ventricular Straein During the Development of Pulmonary Hypertension Assessed With Magnetic Resonance Feature Tracking: An Animal Study.

This animal study used cardiac magnetic resonance (CMR) feature tracking to measure sequential right ventricular (RV) strain during pulmonary hypertension (PH) development in male Wistar rats after monocrotaline injection (with vehicle controls), and correlated imaging findings with histological vascular remodeling. The key finding was that RV strain changed over time in parallel with the progression of PH and vascular remodeling. Scientifically, it supports CMR feature tracking as a sensitive, noninvasive marker of RV functional deterioration during PH evolution.

Kim NY, Im DJ, Hong YJ et al. · Korean journal of radiology · (2026) · View on PubMed ↗ · Free PDF ↗

Feasibility and Yield of a Diagnostic Protocol for Myocardial Infarction With Nonobstructive Coronary Arteries.

This prospective multicenter cohort study enrolled patients with myocardial infarction with nonobstructive coronary arteries (MINOCA) who underwent invasive coronary angiography (ICA) between December 2020 and June 2024 to evaluate a structured diagnostic protocol using ad hoc optical coherence tomography (OCT) for culprit lesion identification. The key finding was that the stepwise protocol beyond initial ICA was feasible and yielded diagnostic workup results despite real-world constraints, with OCT used to identify culprit lesions when appropriate. Clinically, this supports implementing OCT-guided MINOCA evaluation to improve final diagnosis and downstream management in patients who lack obstructive coronary disease.

Nishimiya K, Yosofi B, Dimitriu-Leen AC et al. · The American journal of cardiology · (2026) · View on PubMed ↗ · Free PDF ↗

Prognostic Value of Coronary Sinus Flow and Aortic Pressure Gradient Quantified by 4D Flow CMR in AMI.

This retrospective study evaluated 103 acute myocardial infarction (AMI) patients who underwent CMR prior to percutaneous coronary intervention (PCI) to test whether 4D flow CMR-derived coronary sinus flow (CS flow, normalized to left ventricular mass) and aortic pressure gradients (supra- and sub-aortic peak pressure gradients) predicted outcomes. The key finding was that specific 4D flow CMR hemodynamic measures (CS flow and/or aortic pressure gradients) stratified risk for a composite endpoint including all-cause death, unplanned revascularization, recurrent MI, heart failure rehospitalization, and stroke. This is clinically significant because it suggests 4D flow CMR can provide prognostic biomarkers in AMI beyond standard imaging.

Li Y, Wang S, Li G et al. · Academic radiology · (2026) · View on PubMed ↗

Cardiac magnetic resonance in patients with acute myocardial infarction: The added clinical value.

This review summarized the added clinical value of cardiac magnetic resonance (CMR) in patients with acute myocardial infarction (AMI), emphasizing that CMR is a reference noninvasive modality for comprehensive myocardial injury assessment. The key finding was that CMR can uniquely characterize infarct size, ischemic area at risk, microvascular obstruction, intramyocardial hemorrhage, and interstitial remodeling using advanced late gadolinium enhancement and parametric mapping (native T1, T2, T2*, extracellular volume). Clinically, these tissue-level biomarkers improve prediction of adverse left ventricular remodeling and long-term outcomes beyond standard functional measures like ejection fraction.

Alberti M, Faggioni L, Cioni D et al. · Vascular pharmacology · (2026) · 1 citations · View on PubMed ↗

Cardiac imaging AI and automated analysis (segmentation, motion, radiomics)

Quantitative intramyocardial hemorrhage assessment by conventional T2-weighted imaging improves risk stratification in reperfused STEMI.

This retrospective study developed an AI-powered dual-sequence CT framework to detect myocardial scar using coronary CT angiography (CCTA) and coronary artery calcium (CAC), with CMR as the reference standard. A deep learning nnU-Net model performed automated cardiac segmentation and AHA 17-segment subdivision, enabling global and segmental scar prediction validated against CMR. The technique could reduce reliance on CMR by providing automated scar detection from CT in patients where CMR is limited.

Li Z, Chen Z, Zhang M et al. · The international journal of cardiovascular imaging · (2026) · View on PubMed ↗

Spatial phenotyping of epicardial adipose tissue from cardiac MRI.

This study developed a deep learning framework to spatially phenotype epicardial adipose tissue (EAT) from cardiac MRI by combining automated segmentation with spatial statistical modeling. The key finding was that an asymmetric multi-modal CNN-Transformer network could segment the four cardiac chambers and EAT and then quantify chamber-resolved EAT distribution across the whole heart. Scientifically, this enables more precise mapping of EAT heterogeneity, which may improve understanding of EAT’s role in cardiovascular disease risk.

Feng F, Long T, Hasaballa AI et al. · Medical image analysis · (2026) · View on PubMed ↗ · Free PDF ↗

Deformable image registration for self-supervised cardiac phase detection in cardiac magnetic resonance images of patients with various diseases.

This study proposed a self-supervised deep learning approach using deformable image registration to detect cardiac keyframes for phase detection in short-axis (SAX) and four-chamber (4CH) cine CMR across multiple disease types. The key finding was that the method could automatically detect five keyframes (SAX) and four keyframes (4CH) by learning motion descriptors from self-supervised deformable registration rather than relying only on LV volume curves. Scientifically, improved keyframe detection can enable more accurate temporal alignment and sub-phase analysis for downstream CMR quantification and motion assessment.

Mueller SK, Koehler S, Kiekenap J et al. · Medical image analysis · (2026) · View on PubMed ↗ · Free PDF ↗

ContiMorph: An unsupervised learning framework for cardiac motion tracking with time-continuous diffeomorphism.

This paper studied an unsupervised deep-learning framework, ContiMorph, for time-continuous cardiac motion tracking in image sequences. It introduces a frame-aware U-Net with a time-embedded transformer to learn temporally continuous intra-frame motion fields, addressing limitations of prior methods that rely on scaling-and-squaring (SS) integration for discrete Lagrangian motion fields. The significance is improved motion-tracking accuracy by better exploiting temporal continuity, which can enhance downstream cardiac function assessment and cardiovascular disease diagnosis.

Jiang M, Ruan X, Zheng L et al. · Medical image analysis · (2026) · View on PubMed ↗

Free-Breathing Dynamic, Regularized, Adaptive Cluster Optimization (DRACO) Cine Cardiac MRI in Atrial Fibrillation.

This prospective study evaluated a free-breathing adaptation of Dynamic, Regularized, Adaptive Cluster Optimization (DRACO) cine cardiac MRI in atrial fibrillation (AF), enrolling 10 sinus rhythm subjects and 20 AF subjects and imaging at 3.0 T using balanced SSFP with ECG-gated segmented cine and real-time acquisition. The key finding was that tailored free-breathing DRACO could simultaneously handle cardiac and respiratory motion to generate high-quality, quantifiable cine images in AF. Scientifically and clinically, this advances MRI feasibility for arrhythmia patients who cannot reliably perform breath-holds, potentially improving assessment of AF-related cardiac function.

Ming Z, Pogosyan A, Dong X et al. · Journal of magnetic resonance imaging : JMRI · (2026) · 1 citations · View on PubMed ↗ · Free PDF ↗

Artificial intelligence for right ventricular assessment: current evidence and future directions.

This review article synthesized current evidence and future directions for artificial intelligence (AI) in right ventricular (RV) assessment across echocardiography, cardiac magnetic resonance (CMR), and computed tomography (CT). The key finding was that AI can achieve automated RV segmentation and chamber quantification accuracy approaching interobserver variability, addressing a major limitation of RV imaging interpretation. The scientific and clinical significance is improved reproducibility for RV-based risk stratification in pulmonary hypertension, valvular disease, and congenital heart disease, while identifying remaining gaps for broader deployment.

Tan X, Fowler J, Li M et al. · Current opinion in cardiology · (2026) · 1 citations · View on PubMed ↗

CardioMorphNet: Cardiac motion prediction using a shape-guided Bayesian recurrent deep network.

This study developed CardioMorphNet, a shape-guided Bayesian recurrent deep network for 3D cardiac motion prediction using short-axis (SAX) cine cardiac magnetic resonance (CMR) images, targeting cardiac motion estimation in patients with cardiac abnormalities. The model uses a recurrent variational autoencoder to capture spatiotemporal dependencies across the cardiac cycle and incorporates posterior models for bi-ventricular segmentation to improve deformable registration beyond intensity-only similarity losses. Clinically, this could enhance CMR-derived motion/functional assessment and potentially improve detection and characterization of cardiomyopathies and other cardiac disorders.

Movahed RA, Rezaee A, Zakeri A et al. · Medical image analysis · (2026) · View on PubMed ↗ · Free PDF ↗

Stratification of children with myocarditis using radiomics signatures in LGE cardiovascular MRI.

This work investigated whether radiomics features extracted from late gadolinium enhancement (LGE) cardiovascular MRI can stratify pediatric myocarditis patients by quantifying LGE texture and spatial location. Using radiomics analyses with attention to variability via a digital phantom and resampling strategies, the study derived signatures intended to distinguish pediatric myocarditis subgroups beyond qualitative LGE interpretation. Such MRI radiomics stratification could support more personalized prognosis and risk-adapted management in children with myocarditis.

Laube AP, Huellebrand M, Ter-Minassian L et al. · Computer methods and programs in biomedicine · (2026) · View on PubMed ↗ · Free PDF ↗

CardioRadNet: Cardiac mass diagnosis through integrated segmentation and radiomic analysis.

This study introduced CardioRadNet, an integrated deep learning segmentation plus radiomics classification framework to differentiate benign from malignant cardiac masses using contrast-free T1-weighted cardiac MRI. In 127 pathologically confirmed cases (62 malignant, 65 benign), the approach combined automated segmentation with radiomic features to improve cardiac mass diagnosis without requiring contrast agents. If externally validated, CardioRadNet could streamline and standardize non-contrast cardiac MRI workflows for more accurate triage of rare but clinically critical cardiac masses.

Ferretti M, Pagliaccia M, Baggiano A et al. · Computer methods and programs in biomedicine · (2026) · View on PubMed ↗ · Free PDF ↗

Cardiac sarcoidosis, pericardial disease, and systemic inflammatory causes

Four Synchronous Myxomas Unmasking Carney Complex: When to Think About Carney Complex?

This case report describes a 39-year-old man with multiple synchronous cardiac myxomas discovered during evaluation for ventricular extrasystoles. Multimodality imaging (transesophageal echocardiography, CT, and cardiac MRI) identified four distinct highly mobile lesions, prompting consideration of Carney complex (CNC) as an underlying syndromic cause. The report emphasizes that multiple concurrent myxomas should trigger evaluation for CNC rather than assuming sporadic solitary tumors.

Ballan G, Genovese D, Bortolato A et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗

ECMO-Supported Pericardiectomy in Constrictive Tuberculous Pericarditis With Severe Ventricular Dysfunction.

This case report studied a 20-year-old man with constrictive tuberculous pericarditis causing severe biventricular systolic dysfunction (LVEF <15%) who underwent radical pericardiectomy supported by veno-arterial extracorporeal membrane oxygenation (ECMO) after deterioration despite empirical antituberculosis therapy and optimal heart failure care. The key finding was that ECMO-supported pericardiectomy enabled stabilization and management of refractory cardiogenic shock in the setting of profound ventricular dysfunction. Clinically, it suggests ECMO can be a lifesaving bridge to surgery when tuberculous constrictive pericarditis leads to extreme ventricular failure and conventional medical therapy is insufficient.

Elmorshidy M, Helal A, El-Din M et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗

When rare meets rarer: constrictive pericarditis in Erdheim-Chester disease-a case report.

This case report studied a 57-year-old man with multisystem Erdheim-Chester disease (ECD) who developed exceptionally rare constrictive pericarditis. The key finding was multimodality imaging confirmation of constrictive physiology with marked pericardial thickening on echocardiography, diffuse late gadolinium pericardial enhancement on cardiac magnetic resonance, and circumferential periarterial infiltration on computed tomography. Clinically, it highlights that ECD can present with constrictive pericarditis and that integrated imaging is crucial for diagnosis and management planning.

Dimova-Mileva M, Kanchev I, Marinova E et al. · European heart journal. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗

The role of artificial intelligence in the diagnosis of pericardial constriction.

This review studied the emerging role of artificial intelligence (AI) in diagnosing pericardial constriction, emphasizing how AI may help distinguish constrictive pericarditis from restrictive cardiomyopathy. The key finding (truncated) was that most established AI evidence uses machine learning/deep learning applied to echocardiography, with newer approaches expanding to additional imaging modalities. The significance is that AI could improve diagnostic accuracy in a condition where multimodality integration is often required and misdiagnosis has major clinical consequences.

Lipat K, Booth T, Sengupta PP · Current opinion in cardiology · (2026) · View on PubMed ↗

Multidisciplinary approach in cardiac sarcoidosis: to biopsy or not?

This review studied the diagnostic strategy for cardiac sarcoidosis (CS), comparing endomyocardial biopsy (EMB) against noninvasive imaging within a multidisciplinary diagnostic framework. It concludes that EMB—despite being historically treated as a gold standard—has limited sensitivity with false negatives and can be procedurally risky, leading to increasing reliance on imaging-based approaches. The significance is that it informs modern clinical decision-making on whether tissue confirmation is necessary for diagnosis and management of CS in real-world practice.

Pericao A, Sharma R · Current opinion in pulmonary medicine · (2026) · View on PubMed ↗

Pathway for the Diagnosis and Management of Pericardial Disease: Contemporary Perspective.

This contemporary perspective article reviewed and proposed an updated pathway-based diagnostic and management framework for pericardial disease across five clinical scenarios (e.g., chest pain and hemodynamic collapse) integrating modern consensus guidance. The key finding was that structured, scenario-driven algorithms can standardize multimodal imaging and targeted immunomodulatory therapy implementation despite variable real-world uptake. Clinically, this supports more consistent diagnosis and treatment selection for acute pericarditis, pericardial effusion, cardiac tamponade, and effusive-constrictive pericarditis.

Sivalokanathan S, Herzog E, Haider SW et al. · Critical pathways in cardiology · (2026) · View on PubMed ↗ · Free PDF ↗

Hemorrhagic eosinophilic pericardial effusion associated with probable sparganosis.

This case report described a 25-year-old man with hemorrhagic eosinophilic pericardial effusion after ingesting undercooked frog meat, with diagnostic workup including imaging (CT, cardiac MRI, PET/CT) and next-generation sequencing. The key finding was that the clinical picture—peripheral eosinophilia, eosinophils in pericardial fluid, markedly elevated IgE, and lack of an alternative diagnosis—supported probable sparganosis (Spirometra infection) as the cause. The significance is that sparganosis should be considered in eosinophilic hemorrhagic pericardial effusion after relevant dietary exposure, even when standard cultures and imaging are unrevealing.

Zhu Y, Wang D, Wu Y et al. · International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · (2026) · View on PubMed ↗ · Free PDF ↗

Non-medical imaging/biomarker methods beyond cardiology (e.g., atmospheric science, dialysis causality)

Creating bottom-up RNA transfer vehicles from synthetic protein assemblies.

This Nature study investigated whether AI-designed synthetic protein assemblies can be engineered into bottom-up RNA transfer vehicles independent of viral evolutionary constraints. The authors functionalized designed protein architectures to create nucleic acid transport systems capable of delivering RNA, demonstrating a non-viral route to nucleic acid delivery using generative protein design. This is significant for developing programmable, evolution-independent gene delivery platforms for research and potential therapeutic applications.

Schuhmacher MK, Gruber C, Lang CMR et al. · Nature · (2026) · View on PubMed ↗ · Free PDF ↗

Evolution of ART Medication Adherence Support and Monitoring Across IeDEA Sites: Results From Three Waves of Consortium-Wide Site Assessment Surveys, 2017, 2020 and 2023.

This consortium-wide survey study assessed implementation of HIV guideline–recommended medication adherence support and monitoring across International epidemiology Databases to Evaluate AIDS (IeDEA) sites for adults with HIV in 43 countries using serial cross-sectional clinic surveys from 2017 (n=206), 2020 (n=200), and 2023 (n=214). The key finding was the characterization of how clinic resources and routine adherence support/monitoring practices evolved across the three survey waves. The results are significant for identifying gaps and informing scale-up strategies for adherence support and monitoring in real-world ART programs globally.

Brazier E, Odhiambo F, Edwards JK et al. · Journal of the International AIDS Society · (2026) · View on PubMed ↗ · Free PDF ↗

Lower- Versus Conventional-Sodium Dialysate and Left Ventricular Mass in Patients Receiving Hemodialysis: Causal Analyses of a Randomized Clinical Trial.

This causal analysis studied home and self-care satellite hemodialysis patients to explain why a randomized trial’s allocation to lower dialysate sodium ([Na+]) reduced interdialytic weight gain and BNP but did not reduce left ventricular mass index (LVMI) measured by cardiac magnetic resonance. The key finding (truncated) was the quantification of the causal pathway linking dialysate [Na+] allocation through intermediate physiological variables to LVMI. Clinically, it helps determine which mechanisms drive LVMI in dialysis patients and what dialysate-related targets may be insufficient for reversing cardiac remodeling.

Marshall MR, Vandal AC, Chan CT et al. · Kidney medicine · (2026) · View on PubMed ↗ · Free PDF ↗

Formoterol fumarate attenuates atherosclerosis and improves cardiometabolic dysfunction in ApoE-deficient mice.

This preclinical study tested whether formoterol fumarate, a long-acting β2-adrenergic receptor agonist, attenuates atherosclerosis and cardiometabolic dysfunction in 8-week-old male ApoE-deficient (ApoE KO) mice. Across two doses (0.1 and 0.3 mg/kg/day) for 8 weeks, the key finding (truncated) was improved cardiometabolic and vascular outcomes alongside reduced atherosclerotic burden and organ damage biomarkers. The scientific significance is that β2-agonist therapy may offer a novel, multi-organ protective strategy against atherosclerosis-associated dysfunction in a cardiometabolic disease model.

Juvenal H, Gu W, Zhao Z et al. · Vascular pharmacology · (2026) · View on PubMed ↗

Data-source choice in diabetes mortality surveillance and equity monitoring in the United States, 1999-2023.

This study examined whether the choice of data source changes conclusions about diabetes mortality trends, high-burden jurisdictions, and income-related inequality in the United States from 1999–2023. Using CDC WONDER versus Global Burden of Disease 2023 estimates and multiple statistical methods (e.g., Joinpoint regression, Moran’s I, slope index of inequality, concentration index), the key finding (truncated) was the degree of discrepancy and its impact on trend and equity interpretations. The significance is methodological: surveillance and equity monitoring may yield different policy-relevant conclusions depending on the mortality data source used.

Li WJ, Tao SS, Wang P et al. · Diabetes research and clinical practice · (2026) · View on PubMed ↗

Pathophysiologic Consequences of Early Coarctation Stenting in a Longitudinal Porcine Model.

This longitudinal porcine preclinical study used a swine model of coarctation of the aorta (COA) to compare sham, COA controls, and early COA stenting with serial dilations to adult aortic diameters, assessing mid-to-long-term cardiovascular consequences at terminal study (20 weeks). The key finding was that early stent implantation with serial dilation produced measurable longitudinal cardiovascular pathophysiologic changes compared with COA controls (details truncated in the abstract). Scientifically, it informs how early endovascular treatment may alter vascular remodeling and downstream cardiovascular risk, guiding future stent technology and timing decisions.

Gober LM, Stellon MA, Culver MA et al. · Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions · (2026) · View on PubMed ↗ · Free PDF ↗

Size-resolved microelectrical effects of fine aerosol on nocturnal ozone: Evidence from field observations and statistical modeling.

This study used summertime ground-based observations in Xi’an (2023–2025) to examine how the particle charge-to-mass ratio (CMR) relates to abnormal nocturnal ozone (O3) enhancements under stable nocturnal conditions, applying generalized additive models (GAM), partial least squares structural equation modeling (PLS-SEM), and a simplified interfacial contribution model. The key finding was that particulate electrical properties (via CMR) were significantly associated with nocturnal O3 variations, providing evidence that particle charge can modulate nocturnal O3 chemistry beyond meteorological transport. These results suggest that incorporating aerosol electrical characteristics into atmospheric models could improve mechanistic prediction of nocturnal O3 episodes.

Wang Y, Zhang L, Li J et al. · Environmental research · (2026) · View on PubMed ↗

Reversible alterations of brain acetate metabolism associated with alcohol consumption.

This study examined reversible changes in brain acetate metabolism associated with alcohol consumption by comparing light drinkers, at-risk heavy drinkers, and two groups of individuals with alcohol use disorder (AUD) during medically supervised detoxification at about one week abstinence. The key finding was that brain acetate metabolism shifts with alcohol exposure and recovery status, consistent with prior observations that alcohol alters brain substrate utilization and that heavy drinkers may have increased capacity for acetate oxidation. These results support acetate metabolism as a potentially informative biomarker and mechanistic target in AUD-related neurochemical changes.

Kumaragamage C, Jiang L, Angarita GA et al. · Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · (2026) · View on PubMed ↗ · Free PDF ↗

Intraoperative study of afferent and efferent connections in the upper lumbar spinal cord - Part 1: Cremasteric reflex.

This intraoperative neurophysiology study assessed the feasibility and recording parameters of the cremasteric reflex (CMR) in males under general anesthesia during upper lumbar spinal surgery. Electrical multipulse train stimulation of the upper medial thigh produced cremasteric reflex responses in 23 of 30 cremaster muscles across 15 participants, with an overall recordability rate of 76%. Establishing reliable intraoperative CMR monitoring could expand neurophysiological tools for assessing spinal cord and peripheral reflex pathway integrity during surgery.

de Melo DLM, Oliveira DRDCAB, Madureira PLDS et al. · Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · (2026) · View on PubMed ↗

Cardiovascular complications of systemic diseases (autoimmune, genetic metabolic, dystrophinopathies)

Depressed LV Contractility as a Sentinel of Fulminant Systemic Scleroderma.

This JACC Case Reports article studied fulminant systemic scleroderma (SSc) presenting with depressed left ventricular (LV) contractility in a 21-year-old man. Cardiac MRI showed diffuse gadolinium enhancement and endomyocardial biopsy demonstrated mast cell infiltration with early fibrosis, but despite guideline-directed medical therapy and subsequent cyclophosphamide, cardiac function rapidly deteriorated and the patient died. The case underscores that depressed LV contractility can be an early sentinel of severe cardiac involvement in systemic sclerosis and supports prompt recognition and aggressive management.

Luo M, Branch T, Vasoya D et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗

Cardiac-Predominant Fukutinopathy Caused by Novel Compound Heterozygous FKTN Variants: A Diagnostic and Genetic Odyssey.

This case report studied a cardiac-predominant dystroglycanopathy (fukutinopathy) in a 30-year-old Indian man with dilated cardiomyopathy, persistent QT prolongation, subepicardial late gadolinium enhancement on cardiac MRI, and hyperCKemia. Whole-exome sequencing identified compound heterozygous FKTN variants (c.1112A>G [p.Tyr371Cys] likely pathogenic and c.1224G>T [p.Lys408Asn] of uncertain significance) with parental Sanger sequencing confirming trans inheritance. Clinically, it demonstrates the diagnostic value of genetic testing for FKTN in patients with isolated cardiac phenotypes and guides genotype-directed evaluation in suspected dystroglycanopathies.

Imayavaramban B, Kumar P, Chowdhury RR et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗

Rapidly Progressive Myocarditis and Cardiogenic Shock: The Failing Heart in Systemic Sclerosis.

This JACC Case Reports article studied rapidly progressive myocarditis leading to cardiogenic shock in a 49-year-old woman with diffuse systemic sclerosis (SSc). Echocardiography showed severe biventricular systolic dysfunction with markedly elevated cardiac biomarkers, and cardiac MRI demonstrated diffuse biventricular myocardial inflammation that was confirmed by endomyocardial biopsy showing lymphocytic infiltration. The case is significant because it emphasizes that fulminant myocarditis with shock can be an under-recognized initial cardiac manifestation of SSc requiring urgent diagnosis and treatment.

Mohammad F, Alhajri N, Al-Matrooshi N et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗

Sudden Cardiac Arrest and Takotsubo-Like Cardiomyopathy as the Initial Presentation of Primary Carnitine Deficiency.

This case report studied primary carnitine deficiency (PCD) presenting with sudden cardiac arrest and Takotsubo-like cardiomyopathy in an 18-year-old female. Genetic testing identified a homozygous pathogenic variant in SLC22A5 (c.43G>T; p.Gly15Trp), and cardiac MRI showed a Takotsubo-like phenotype after ventricular fibrillation cardiac arrest with otherwise normal anatomy. Clinically, it reinforces that SLC22A5-related PCD is a treatable cause of life-threatening arrhythmia and cardiomyopathy that should be considered in unexplained sudden cardiac arrest.

Talasani N, Przybylski R, Delaney MA et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗

Phenotypic overlap masking MELAS in Turner syndrome: a diagnostic challenge.

This case report studied a 51-year-old woman with mosaic Turner syndrome whose clinical and cardiac features (including concentric left ventricular hypertrophy and mildly reduced systolic function, LVEF 45%) overlapped with mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS), creating a diagnostic challenge. The key finding was that phenotypic overlap with Turner syndrome can mask MELAS and delay correct diagnosis. The clinical significance is that clinicians should consider mitochondrial disease (e.g., MELAS) when Turner syndrome patients present with atypical multisystem findings, to avoid mismanagement from diagnostic anchoring.

Shinozaki T, Sumiyoshi H, Ueshima D et al. · European heart journal. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗

Left ventricular myocardial strain analysis by feature tracking cardiac magnetic resonance in patients with autoimmune rheumatic diseases: A case-control study.

This case-control study evaluated left ventricular myocardial strain measured by cardiac magnetic resonance feature tracking (CMR-FT) in 30 patients with autoimmune rheumatic diseases (ARDs) versus 10 matched healthy controls. The key finding was that CMR-FT strain analysis detected subclinical left ventricular dysfunction in ARD patients despite preserved conventional cardiac function. Scientifically and clinically, it supports CMR-FT as a sensitive tool for early detection of myocardial involvement in ARDs.

ElMahdy EKA, Ibrahim AS, AbdulRahim SAA et al. · La Clinica terapeutica · (2026) · View on PubMed ↗

Rheumatoid arthritis and multisite cardiac aneurysms involving the LVOT, valves, and intervalvular Fibrosa: A case-based systematic review.

This case-based systematic review examined rheumatoid arthritis (RA)–associated aneurysmal or pseudoaneurysmal cardiac involvement affecting the left ventricular outflow tract (LVOT), valves, and intervalvular fibrosa. The key finding was that such RA-related aneurysms/pseudoaneurysms are exceptionally rare and have been reported mainly as isolated case reports with variable clinical presentation, imaging/pathology findings, and management strategies. The significance is that clinicians should consider RA-related peri-annular/subvalvular fibrous complications when evaluating unusual LVOT/aortic root aneurysms in RA patients.

Alberti M, Cito V, Capozza P et al. · Vascular pharmacology · (2026) · 1 citations · View on PubMed ↗

Cardiac Safety Outcomes in Delandistrogene Moxeparvovec Clinical Trials for Duchenne Muscular Dystrophy with Up to 5 Years of Follow-up.

This report studied cardiac safety outcomes of the gene transfer therapy delandistrogene moxeparvovec in Duchenne muscular dystrophy (DMD) patients across multiple clinical trials with up to 5 years of follow-up. Across trials (101, 102, ENDEAVOR, and EMBARK) that excluded patients with LVEF <40%, it evaluated adverse events, serial echocardiography, and biomarker monitoring including troponin I. The significance is that it characterizes the cardiac risk profile of dystrophin gene delivery over longer follow-up, informing benefit–risk assessment for DMD patients receiving this therapy.

Veerapandiyan A, Bourke J, Soslow JH et al. · Cardiology and therapy · (2026) · View on PubMed ↗ · Free PDF ↗

Heart involvements in systemic sclerosis beyond pulmonary hypertension: From conduction, rhythm and function defects to coronary artery disease.

This narrative review summarized cardiac involvement in systemic sclerosis (SSc) beyond pulmonary hypertension, focusing on conduction and rhythm abnormalities, cardiac function defects, and progression to coronary artery disease including coronary microvascular dysfunction. The key finding was that, even independent of pulmonary arterial hypertension, SSc commonly causes clinically overt cardiac disease (15–35%) and subclinical dysfunction (~70%) detectable with advanced screening, contributing to morbidity and mortality. Scientifically, it highlights the need for systematic cardiac surveillance and multimodal evaluation in SSc to detect early coronary and electrical complications.

Barile R, Rotondo C, Giancaspro G et al. · La Revue de medecine interne · (2026) · View on PubMed ↗

Microvascular dysfunction and neurovascular signalling impairment in diabetic silent myocardial ischemia.

This mechanistic review examined diabetic silent myocardial ischemia (DSMI) in the context of diabetic microvascular dysfunction and neurovascular signaling impairment. The key finding was that chronic hyperglycemia-driven oxidative stress, advanced glycation end-product (AGE) accumulation, and mitochondrial dysfunction reduce nitric oxide (NO) bioavailability and impair coronary flow reserve and capillary integrity, while diabetic peripheral/autonomic neuropathy blunts nociceptive signaling. Clinically, clarifying these pathways supports developing targeted therapies to prevent silent ischemic events in diabetes despite absent symptoms.

Rajasekaran HK · Microvascular research · (2026) · View on PubMed ↗

Repurposing Empagliflozin for Duchenne Muscular Dystrophy-Associated Cardiomyopathy: Protocol for a Pharmacokinetics, Safety and Proof-of-Concept Trial in Children.

This protocol describes a single-arm, open-label phase 2 pharmacokinetics, safety, and proof-of-concept trial repurposing empagliflozin for Duchenne muscular dystrophy (DMD)-associated cardiomyopathy in children. The trial will characterize empagliflozin pharmacokinetics, assess safety and ease-of-swallow, and explore efficacy and efficacy markers in this pediatric DMD population. If successful, empagliflozin could become a targeted disease-modifying or heart-failure–preventive therapy for DMD cardiomyopathy where current treatments remain inadequate.

Lava SAG, Laurence C, Mallory J et al. · Cardiology and therapy · (2026) · View on PubMed ↗ · Free PDF ↗

Cardiovascular imaging in pregnancy and special populations

Managing pregnancy in women with pre-existing cardiomyopathies: A case series.

This case series studied pregnancy management in women with pre-existing cardiomyopathies, including dilated, hypertrophic, and arrhythmogenic cardiomyopathy, focusing on maternal and fetal outcomes across pregnancy, delivery, and postpartum. The key finding was that pregnancy courses differed by cardiomyopathy phenotype, with major complications including arrhythmia, rising left ventricular outflow tract obstruction, and heart failure, and that management relied on pre-conception planning, biomarkers, and tailored pharmacologic/device strategies. Clinically, it underscores the need for phenotype-specific risk assessment and coordinated multidisciplinary management for safer pregnancy in women with cardiomyopathy.

Bruce C, Montanaro C, Wander G et al. · Case reports in women’s health · (2026) · View on PubMed ↗ · Free PDF ↗

Cardiac volumes, function, and arterial stiffness five years after severe preeclampsia: A comparison with sedentary and active controls.

This study investigated cardiovascular outcomes 5 years after severe preeclampsia in women (n=10) compared with normotensive pregnancy controls (n=20, including lifestyle-matched and physically active groups) using cardiac magnetic resonance. The key finding (details truncated) was the comparative assessment of cardiac volumes, function, and arterial stiffness across groups, powered to detect ~5% differences by CMR. Scientifically, it aims to clarify long-term cardiovascular mechanisms after severe preeclampsia and identify whether physical activity modifies later cardiovascular risk.

Edvinsson C, Steding-Ehrenborg K, Venkateshvaran A et al. · Clinical physiology and functional imaging · (2026) · View on PubMed ↗ · Free PDF ↗

Cardiac MRI for cardiomyopathies (HCM and other genetic/structural diseases)

This case report studied a 44-year-old man with suspected hypertrophic cardiomyopathy phenotype and a maternal family history, focusing on PRKAG2-related cardiomyopathy with ventricular hypertrophy and pre-excitation. Cardiac magnetic resonance showed asymmetric hypertrophy with extensive late gadolinium enhancement and early adverse remodeling, and after primary prevention ICD implantation genetic testing identified a heterozygous PRKAG2 variant (truncated in abstract). Clinically, the report highlights ventricular hypertrophy plus pre-excitation as a diagnostic clue to PRKAG2-related cardiomyopathy to avoid misclassification and guide appropriate genetic evaluation and risk management.

Quadrini F, Rodio D, Maddaluna P et al. · Giornale italiano di cardiologia (2006) · (2026) · View on PubMed ↗

Enhanced risk stratification in hypertrophic cardiomyopathy through the integration of extracellular volume fraction on cardiovascular magnetic resonance.

This study evaluated whether cardiovascular magnetic resonance (CMR) extracellular volume fraction (ECV), a marker of diffuse interstitial fibrosis, improves risk prediction in 990 consecutive hypertrophic cardiomyopathy (HCM) patients beyond late gadolinium enhancement (LGE). During a median 3.2-year follow-up, higher ECV provided incremental prognostic value for HCM-related events (including sudden cardiac death, heart failure, and HCM-related death) over LGE alone. The results are scientifically and clinically important because they suggest adding global ECV to CMR risk stratification could better identify HCM patients at higher risk for adverse outcomes.

Lee HJ, Gwak SY, Lee S et al. · European heart journal. Cardiovascular Imaging · (2026) · 1 citations · View on PubMed ↗

Left atrial reservoir strain for predicting progression to end-stage in hypertrophic cardiomyopathy.

This prospective cohort study analyzed 925 patients with hypertrophic cardiomyopathy (HCM) undergoing serial echocardiography to identify predictors of progression to end-stage HCM (left ventricular ejection fraction <50% without reversible causes), with a cardiovascular magnetic resonance (CMR) subcohort of 491 patients. The key finding was that left atrial reservoir strain measured by echocardiography/CMR-related assessment was predictive of progression to end-stage HCM during a median 6.5-year follow-up. This supports using left atrial reservoir strain as an imaging biomarker to improve risk stratification and guide earlier management in HCM.

Kwak S, Jeong MH, Park CS et al. · European heart journal. Cardiovascular Imaging · (2026) · 1 citations · View on PubMed ↗

Prognostic Value of MRI-Based Left Ventricular Trabecular Complexity for Sudden Cardiac Death in Hypertrophic Cardiomyopathy.

This prospective study evaluated MRI-based left ventricular (LV) myocardial trabecular complexity using fractal dimension (FD) to predict sudden cardiac death (SCD) in 835 patients with hypertrophic cardiomyopathy (HCM), using 3 T SSFP cine imaging with blinded interpretation. The key finding was that higher LV trabecular complexity (FD) was associated with increased SCD risk and showed relationships with sarcomere genetic variants. This provides a noninvasive CMR-derived risk marker that could refine SCD prevention strategies in HCM.

Zhang J, Yu M, Pu L et al. · Journal of magnetic resonance imaging : JMRI · (2026) · 1 citations · View on PubMed ↗ · Free PDF ↗

Heart failure and precision/AI-guided intervention planning

Precision-guided heart failure interventions: The expanding role of advanced cardiac imaging and artificial intelligence.

This article reviewed precision-guided heart failure interventions and the expanding roles of advanced cardiac imaging and artificial intelligence across contemporary heart failure care. The key finding was that integrating imaging/AI into three precision domains—anatomy, myocardial substrate, and physiology—supports more tailored decisions for interventions such as transcatheter valve therapy, cardiac resynchronization/pacing, complex coronary procedures, invasive hemodynamic assessment, and implantable pressure sensors. Scientifically and clinically, the synthesis highlights how imaging-driven phenotyping can improve selection of therapies beyond standard pharmacologic approaches.

Albulushi A, Al-Farhan H · American heart journal plus : cardiology research and practice · (2026) · View on PubMed ↗ · Free PDF ↗

Viability testing for guiding revascularization in ischemic cardiomyopathy.

This review studied the clinical role of myocardial viability testing to guide revascularization decisions in patients with ischemic cardiomyopathy, focusing on how dysfunctional-but-viable myocardium is used to predict recovery after CABG. It reports that contemporary evidence—particularly from the STICH trial and follow-up—shows CABG improves long-term survival largely independent of viability status, challenging the traditional viability-guided paradigm. The finding is clinically significant because it supports re-evaluating viability testing’s routine use when modern guideline-directed medical therapy and current revascularization strategies are available.

Li KY, Dhingra NK, Patel R et al. · Current opinion in cardiology · (2026) · View on PubMed ↗

Exercise, lifestyle, and functional testing as cardiovascular risk modifiers

The Relationship Between Physical Activity and Left Ventricular Remodeling in Childhood Cancer Survivors Treated With Anthracyclines: A Cross-Sectional Study.

This cross-sectional study assessed how moderate-to-vigorous physical activity (MVPA), measured by accelerometry, relates to LV remodeling in childhood cancer survivors treated with anthracyclines using cardiovascular magnetic resonance (CMR). The key finding was that MVPA was associated with CMR-derived measures of cardiac remodeling, including indexed end-diastolic LV mass (LVMi), LV end-diastolic volume (LVEDVi), mass:volume ratio, and LV ejection fraction (LVEF). The clinical significance is that physical activity may be a modifiable factor linked to earlier anthracycline-related remodeling trajectories, potentially informing survivorship risk management.

Narayan HK, Chen S, Wong FL et al. · Pediatric blood & cancer · (2026) · View on PubMed ↗

Subclinical Origins of Cardiometabolic Risk in Indian Adolescents: A Cross-Sectional Study.

This cross-sectional study assessed cardiometabolic risk in apparently healthy Indian adolescents (ages 11–16) by relating body fat and hepatic fat to cardiometabolic risk factors. Using MRI proton density fat fraction (PDFF) on a 3.0T system and whole-body fat by dual-energy X-ray absorptiometry (DXA), the study found that a substantial proportion of adolescents had at least one cardiometabolic risk factor and that fat measures were associated with these risk markers. The findings suggest subclinical cardiometabolic risk may begin in adolescence and could be identified using noninvasive imaging and routine clinical measures.

Hegde SG, Kankara SR, Raj JM et al. · Indian pediatrics · (2026) · View on PubMed ↗

Unmasking subclinical cardiomyopathy: The role of cardiopulmonary exercise testing when screening genotype-positive phenotype negative relatives.

This case series evaluated whether cardiopulmonary exercise testing (CPET) can unmask subclinical cardiomyopathy in gene-positive, phenotype-negative (G+P-) relatives identified through cascade testing in cardiomyopathy families. Among relatives who underwent extensive phenotyping (ECG, echocardiography, Holter monitoring, and cardiac MRI), CPET was assessed for its ability to detect abnormalities not evident on conventional screening. If CPET improves sensitivity in G+P- relatives, it could refine surveillance strategies and earlier intervention timing for individuals at genetic risk.

Abela M, Scicluna J, Debattista J et al. · International journal of cardiology · (2026) · View on PubMed ↗

Non-cardiac oncology (imaging endpoints and cancer biology)

SMARCA4, STK11, and KEAP1 co-inactivation associates with poor prognosis and upregulation of the TGF-β pathway in lung adenocarcinoma.

This translational oncology study investigated lung adenocarcinoma (LUAD) tumors with co-inactivation of SMARCA4, STK11, and KEAP1 and tested how these alterations relate to prognosis and TGF-β pathway activity. The key finding was that SMARCA4/STK11/KEAP1 co-inactivation was associated with poor prognosis and increased upregulation of the TGF-β pathway. Clinically, the results suggest that this multigene loss pattern could identify a high-risk LUAD subgroup with potential relevance for TGF-β–targeted therapeutic strategies.

Costa EA, Mello BP, Wohlhieter C et al. · Translational oncology · (2026) · View on PubMed ↗ · Free PDF ↗

Outcomes From the Multicenter ACCRU-LY-1804/CARiBOU TRIAL (Cytarabine, Acalabrutinib and Rituximab Integrated With Bortezomib-Based Outpatient Therapy) in 1st Line Mantle Cell Lymphoma.

This phase 2 multicenter ACCRU-LY-1804/CARiBOU trial evaluated first-line therapy for previously untreated mantle cell lymphoma (MCL) using a regimen combining alternating VR-CAP and R-cytarabine with continuous acalabrutinib over six 21-day cycles, with bortezomib-based outpatient therapy integration. The key finding was the trial’s reported complete metabolic response (CMR) rate as the primary endpoint, along with feasibility/safety outcomes and progression-free survival (PFS) and overall survival (OS) measures (abstract truncated). Clinically, the results inform whether this multitargeted chemoimmunotherapy approach can achieve durable responses and potentially enable more patients to proceed to stem cell collection and autologous stem cell transplant (ASCT).

Smith SD, Sundaram S, Giri S et al. · American journal of hematology · (2026) · View on PubMed ↗ · Free PDF ↗

Valvular heart disease and transcatheter repair planning

An integrative approach to patient selection for mitral transcatheter edge-to-edge repair in secondary mitral regurgitation.

This review studied how to select patients for mitral transcatheter edge-to-edge repair (M-TEER) in secondary mitral regurgitation (SMR) by integrating evidence from randomized trials, proportionality concepts, and multimodality imaging. It finds that differences in outcomes between MITRA-FR and COAPT are largely attributable to echocardiographic selection and left-ventricular remodeling, implying SMR severity should be interpreted relative to ventricular size and regurgitant context. The clinical significance is a structured approach to identifying SMR patients most likely to benefit from M-TEER despite ongoing variability in trial inclusion criteria.

Brusosa M, Flores-Umanzor E, Horlick E · Current opinion in cardiology · (2026) · View on PubMed ↗

Advances in artificial intelligence for the evaluation of mitral regurgitation.

This review synthesized evidence on artificial intelligence (AI) tools for mitral regurgitation (MR) evaluation across the diagnostic pathway, including pre-imaging screening and multimodality imaging, and discussed clinical integration. The key finding was that AI-enabled digital stethoscopes and deep learning–based electrocardiographic models can support scalable upstream detection and population-level risk stratification, but currently act mainly as enrichment tools rather than standalone diagnostics. Clinically, this positions AI as an adjunct to reduce time and interobserver variability in MR workup while highlighting the need for stronger validation for independent decision-making.

Sanchez AA, Sadeghpour A, Asch FM · Current opinion in cardiology · (2026) · View on PubMed ↗

Mitral Regurgitation Assessment Using a Novel Automated Three-Dimensional Color-Flow Quantification: Comparison with Two-Dimensional Proximal Isovelocity Surface Area and Cardiac Magnetic Resonance.

This retrospective study evaluated a novel automated three-dimensional color-flow quantification (3D Auto CFQ) tool for mitral regurgitation (MR) severity and regurgitant volume in 185 consecutive patients undergoing transesophageal echocardiography (TEE), comparing it with two-dimensional proximal isovelocity surface area (2D PISA). 3D Auto CFQ showed feasibility and performance for MR quantification relative to 2D PISA, addressing limitations of 2D geometric assumptions and single-frame analysis. If validated prospectively, automated 3D TEE-based MR quantification could improve accuracy and standardization of MR assessment for clinical decision-making and trials.

Kim K, Lee SH, Lee HJ et al. · Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography · (2026) · View on PubMed ↗

Generated automatically on September 05, 2026. Covers PubMed articles published August 29, 2026 – September 05, 2026. Summaries are AI-generated; always consult the original publication for clinical or research decisions.

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