What's New in Cardiac MRI? — September 18, 2026
AI-summarised digest of 37 PubMed articles on Cardiac MRI published in the last 7 days.
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What’s New in Cardiac MRI?
September 18, 2026 · 37 articles · 15 research themes · covering September 11, 2026 – September 18, 2026
Overview
Across this week’s set of papers, a dominant theme is the push toward more precise cardiovascular phenotyping using advanced imaging—especially cardiac MRI and echocardiography—and increasingly, AI-enabled workflows. Reviews and studies highlight how next-generation reconstruction, AI-supported segmentation, and refined strain/deformation metrics can improve diagnostic accuracy and localize dysfunction beyond traditional global measures. Several CMR-focused investigations also emphasize risk stratification through tissue characterization (e.g., late gadolinium enhancement) and remodeling signatures, including in mitral valve prolapse, post–STEMI remodeling, and atrial tissue changes after pulmonary vein isolation.
A second major thread is “mechanism-to-management” translation: linking pathobiology to clinical decision-making. In infiltrative and genetic cardiomyopathies (cardiac amyloidosis, DSP cardiomyopathy), papers stress earlier detection and phenotype recognition to guide surveillance and risk assessment. In post-MI and inflammatory contexts, work ranges from invasive hemodynamic markers of microvascular obstruction to preclinical studies of viral latency and inflammation-driven remodeling, collectively reinforcing that the heart’s response to injury is shaped by both local tissue processes and systemic immune/metabolic factors.
Finally, the digest includes targeted therapeutic and systems-level advances. Trials and cohort analyses explore whether medical strategies can interrupt remodeling “vicious cycles” (e.g., functional tricuspid regurgitation) and how to safely extend reassurance after normal stress imaging via “warranty periods.” Complementing this, operational and patient-centered imaging strategies (protocol optimization, endotype-informed care for ANOCA) aim to reduce uncertainty and improve access without sacrificing quality—while preclinical studies suggest that metabolic and incretin-pathway therapies may have sex- and context-dependent cardiovascular effects.
AI & Next-Generation Cardiovascular Imaging
Myocardial Strain Evaluation from Cardiovascular MRI and CT: Physiological Principles and Clinical Perspectives.
This review studied how myocardial deformation (strain) can be measured from cardiovascular imaging—specifically cardiac magnetic resonance (CMR) and cardiac computed tomography (CCT)—to provide local, physiology-linked markers of myocardial function. It found that strain reflects emergent deformation driven by mesostructural fiber and sheetlet architecture and that both CMR and CCT have evolving technical methods to quantify it. Clinically, strain-based local assessment may improve sensitivity and specificity for detecting myocardial dysfunction beyond limited global metrics.
Hussein TM, Pourmorteza A, Oshinski JN · The British journal of radiology · (2026) · View on PubMed ↗
Improving Cardiac Magnetic Resonance Scanning Efficiency: Impact on Diagnostic Image Quality and Patient Management.
This JACC case report studied a workflow intervention to improve cardiovascular magnetic resonance (CMR) scanning efficiency using a scanner library of optimized, pathology-driven protocols plus real-time hybrid supervision by an advanced imaging cardiologist. It found that over 12 months (retrospective review of 499 charts: 160 preintervention, 339 postintervention) the dual-intervention strategy reduced CMR scan times by 38.6% with median times dropping from 84.7 minutes (and improved diagnostic image quality and patient management outcomes). The significance is that operational optimization can increase CMR throughput without sacrificing image quality, potentially improving access to cardiac imaging.
Odigie-Okon E, Ogunleye O, Saxena R et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗
Endotype-informed therapy and effects on illness perception and psychological health in patients with chest pain and no obstructive coronary artery disease.
This prospective, multicentre randomized controlled superiority trial studied whether endotype-informed therapy using non-invasive stress perfusion cardiovascular magnetic resonance (CMR) improves illness perception and psychological health in patients with chest pain and no obstructive coronary artery disease (ANOCA) compared with standard angiography-guided care in the CorCMR trial. The key finding (from the truncated abstract) is that defining ischaemic endotypes with stress perfusion CMR and guiding targeted therapy was evaluated as a strategy to reduce diagnostic uncertainty–related symptoms and psychological distress. If effective, this approach would support CMR-based endotyping as a patient-centered diagnostic and therapeutic pathway in ANOCA.
Bradley CP, McKinley G, Orchard V et al. · European heart journal. Quality of care & clinical outcomes · (2026) · 1 citations · View on PubMed ↗ · Free PDF ↗
The Exciting Future of Cardiovascular Imaging.
This review article studied how emerging technologies—new imaging hardware, reconstruction algorithms, and artificial intelligence—are transforming cardiovascular imaging across echocardiography, computed tomography, cardiac magnetic resonance, and nuclear imaging. It found that these advances collectively improve diagnostic accuracy, refine risk stratification, optimize therapy planning, and enable monitoring of treatment response through AI-supported workflows from acquisition to segmentation/reconstruction. The clinical significance is that integrated AI and next-generation reconstruction are likely to accelerate more precise, personalized cardiovascular care.
Gräni C, Bucciarelli-Ducci C, Dweck MR et al. · JACC. Cardiovascular imaging · (2026) · View on PubMed ↗ · Free PDF ↗
Genetic & Molecular Mechanisms (Ubiquitin Signaling, FXI, DSP) and Translational Biomarkers
Fulminant Biventricular Desmoplakin Cardiomyopathy With a Myocarditis-Like Presentation.
This case report studied a 23-year-old man with desmoplakin (DSP) cardiomyopathy presenting with a myocarditis-like phenotype after intermittent fever. It found rapidly progressive fulminant biventricular failure (LVEF 11%), ventricular ectopy with nonsustained ventricular tachycardia, and CMR showing extensive circumferential subepicardial ring-like fibrosis, with infectious/autoimmune/infiltrative/toxic causes excluded and whole-exome sequencing identifying a likely pathogenic DSP variant. The significance is that DSP cardiomyopathy can mimic myocarditis, so early genetic diagnosis and risk stratification are crucial in young patients with myocarditis-like presentations.
Byreddi B, Kumar P, Imayavaramban B et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗
Association of F11 Gene Variants With Cardiovascular Events and Cardiac Function.
This prospective UK Biobank study investigated associations between F11 gene variants (used to model genetic FXI inhibition) and cardiovascular events and cardiac function in 408,642 European-ancestry participants. It found that genetically proxied FXI inhibition was associated with cardiovascular outcomes and measures of cardiac function (analyzed using Cox and linear regression models with two F11-based genetic scores weighted by activated partial thromboplastin time or circulating FXI levels). The significance is that genetic evidence can clarify whether FXI-targeted antithrombotic strategies may influence heart failure risk and related cardiac phenotypes.
Ye Q, Hu S, Yang R et al. · Journal of the American Heart Association · (2026) · View on PubMed ↗ · Free PDF ↗
Gene-environment interactions shape cytokine-mediated inflammation and cardiovascular risk.
This study examined how cytokine-mediated inflammation interacts with environmental and genetic factors to shape cardiovascular risk and cardiac remodeling in 488,079 UK Biobank participants with metabolomic/proteomic profiling and cardiac magnetic resonance (CMR). It found that chronic inflammation quantified by glycoprotein acetyls (GlycA) by nuclear magnetic resonance spectroscopy, together with machine-learning analyses, related to cardiovascular risk and CMR-derived cardiac phenotypes while being modulated by genetic and environmental influences. The significance is improved mechanistic understanding of inflammation-to-remodeling pathways that could refine cardiovascular risk prediction and stratification.
Corianò M, Tahasildar S, Huang L et al. · European journal of preventive cardiology · (2026) · View on PubMed ↗ · Free PDF ↗
Clinical Pharmacokinetics and Disposition of Imrecoxib.
This narrative review studied the clinical pharmacokinetics and disposition of imrecoxib, a COX-2–preferential nonsteroidal anti-inflammatory drug approved in China for osteoarthritis. It found that after oral dosing imrecoxib reaches peak plasma concentrations in 2–3 hours, that food increases systemic exposure, and that metabolism proceeds sequentially from imrecoxib (M0) to 4’-hydroxymethylimrecoxib (M1), then to 4’-formylimrecoxib (M-CHO), and finally to 4’-carboxyimrecoxib (M2). The significance is that these data inform dosing considerations, special-population use, and drug–drug interaction risk when using imrecoxib clinically.
Zhao S, Li C, Mallillin MC et al. · Clinical pharmacokinetics · (2026) · View on PubMed ↗
Molecular mechanism of HUWE1-HAPSTR1-USP7-mediated ubiquitin chain amplification on nuclear proteins.
This mechanistic study examined how the HUWE1–HAPSTR1–USP7 axis amplifies ubiquitin chains on nuclear proteins, focusing on HUWE1’s role as a ubiquitin chain amplifier. It found that HUWE1 captures pre-ubiquitinated substrates and assembles long ubiquitin chains with K11–K48 branch points, with HAPSTR1 and USP7 regulating the process, supported by structural and biochemical analyses. The significance is a clearer molecular mechanism for stress-adaptive protein degradation that may inform therapeutic targeting of ubiquitin signaling in disease.
Yatskevich S, Mohapatra J, Mroue R et al. · Molecular cell · (2026) · View on PubMed ↗
Assessment of carcinogenic, mutagenic, and reprotoxic (CMR) substance exposure levels outside supplied-air respirators during shipboard spray painting in confined spaces.
This case report studied occupational exposure to carcinogenic, mutagenic, and reprotoxic (CMR) substances during shipboard spray painting in confined spaces among 15 workers across five shipyard companies in South Korea, using activated charcoal tubes and passive samplers placed outside supplied-air respirator facepieces. Environmental sampling during active spray painting (15 workers, eight measurement sites, three painting products) quantified actual external exposure levels to mixed organic solvents and other CMR-related chemicals. The findings highlight that supplied-air respirators may not fully prevent real-world CMR exposure during confined-space spray painting, supporting the need for improved exposure controls and monitoring.
Kim YJ, Kim KY · Industrial health · (2026) · View on PubMed ↗ · Free PDF ↗
The changing therapeutic landscape of small-cell lung cancer.
This Lancet review summarized the evolving therapeutic landscape for small-cell lung cancer (SCLC), focusing on how advances in understanding SCLC biology and cell-surface targets are enabling new treatment strategies beyond standard chemotherapy. It highlights that identifying uniquely or differentially expressed cell-surface proteins has led to targeted therapies with early evidence of efficacy. The significance is that SCLC treatment is shifting toward biology-driven targeted approaches, potentially improving outcomes in a disease historically resistant to cytotoxic therapies.
Ross JS, Hockemeyer KG, Redin E et al. · Lancet (London, England) · (2026) · 2 citations · View on PubMed ↗
Mitral Valve Prolapse & Arrhythmogenic Phenotypes
Myocardial late gadolinium enhancement is strongly associated with ventricular arrhythmias in mitral valve prolapse.
This observational study evaluated whether myocardial late gadolinium enhancement (LGE) on CMR is associated with ventricular arrhythmias in 45 consecutive patients with mitral valve prolapse (MVP). It found that higher myocardial LGE burden—quantified as percent of left ventricular mass and analyzed by tertiles (0%, 1–4%, and ≥5%)—was strongly associated with ventricular arrhythmias detected by 24-hour Holter monitoring and exercise stress testing. The significance is that CMR myocardial LGE can help identify MVP patients at higher risk for ventricular arrhythmias and may support risk stratification for preventive management.
Vedernikov NL, Goitein O, Goldkorn R et al. · The international journal of cardiovascular imaging · (2026) · View on PubMed ↗ · Free PDF ↗
Accessory Pathways in Arrhythmogenic Right Ventricular Cardiomyopathy: A Two-Case Series and Literature Review.
This two-case series and literature review studied arrhythmogenic right ventricular cardiomyopathy (ARVC) patients with exceptionally rare accessory pathways, focusing on concealed pathways without ventricular pre-excitation in two young individuals. The authors identified supraventricular tachycardia mediated by a left lateral retrograde-only accessory pathway in a 27-year-old male with family history of sudden cardiac death, and reported a second ARVC case with a concealed accessory pathway (details truncated). Clinically, recognizing accessory pathways in ARVC—especially concealed retrograde pathways—can refine electrophysiology evaluation and risk management for arrhythmia and sudden death.
Leiria TLL, de Lima GG, Baroni AC et al. · Indian pacing and electrophysiology journal · (2026) · View on PubMed ↗ · Free PDF ↗
Mitral valve prolapse: New clinical and scientific insights in 2026.
This review studied mitral valve prolapse (MVP) and its evolving clinical and scientific understanding, including anatomical subtypes (Barlow’s disease vs fibroelastic deficiency) and arrhythmogenic features. It found that a “malignant” MVP phenotype—bileaflet prolapse with mitral annular disjunction (MAD) and myocardial fibrosis—has emerged as a substrate for ventricular arrhythmias and sudden cardiac death. The clinical significance is that modern imaging (e.g., echocardiography and related modalities) can help identify high-risk MVP patients for closer surveillance and potential targeted management.
Yamaguchi M, Madhyastha R, Furukawa K et al. · Journal of cardiology · (2026) · View on PubMed ↗
Cardiac Amyloidosis & Valvular Disease
Subclinical cardiomyopathy in premanifest carriers of late-onset hereditary transthyretin amyloidosis with polyneuropathy.
This study investigated subclinical cardiomyopathy in premanifest carriers of late-onset hereditary transthyretin amyloidosis with polyneuropathy (ATTRv-PN), specifically those with the transthyretin p.A117S variant. It found that cardiomyopathy risk (estimated using the Mayo ATTR-CM score) and early cardiac involvement could be detected in the premanifest stage using echocardiography, 99mTc-pyrophosphate (PYP) SPECT, and cardiac magnetic resonance, and that these cardiac phenotypes correlated with clinical and neurological measures. The significance is earlier identification of cardiac involvement before overt symptoms, enabling timely monitoring and potential intervention in ATTRv-PN.
Wang TW, Su MY, Cheng MF et al. · Journal of the Formosan Medical Association = Taiwan yi zhi · (2026) · View on PubMed ↗ · Free PDF ↗
VALVE DISEASES IN CARDIAC AMYLOIDOSIS: WHAT WE HAVE TO KNOW.
This review studied valvular manifestations in cardiac amyloidosis, focusing on how amyloid deposition from immunoglobulin light chains (AL) or transthyretin (ATTR) affects valves, especially aortic stenosis (AS). It found that AS is the most prevalent valvular manifestation—particularly in wild-type ATTR—and that concomitant cardiac amyloidosis and AS can interact synergistically to worsen ventricular loading and outcomes. Clinically, improved recognition of valve disease patterns in CA is important for risk assessment and management of patients with infiltrative cardiomyopathy.
Lisi DD, Salvo FD, Castro F et al. · Current problems in cardiology · (2026) · View on PubMed ↗ · Free PDF ↗
Cardiac Sarcoidosis & Device-Related Arrhythmia Risk
Monitoring disease activity in eosinophilic granulomatosis with polyangiitis: a scoping review.
This scoping review studied methods to monitor disease activity and treatment response in eosinophilic granulomatosis with polyangiitis (EGPA), focusing on limitations of conventional tools like the Birmingham Vasculitis Activity Score (BVAS). It found that current monitoring approaches span biomarkers, imaging, and other procedures, but that many tools inadequately capture EGPA-specific respiratory and eosinophilic features. The significance is that a structured inventory of available monitoring strategies can guide development of better EGPA-specific disease activity measures.
Tesi M, Fibbi I, Rella C et al. · Clinical and experimental rheumatology · (2026) · View on PubMed ↗
High prevalence of coxsackievirus B antibodies in patients with cardiac sarcoidosis: a retrospective cohort study.
This retrospective cohort study evaluated whether coxsackievirus B (CVB) antibodies are associated with cardiac sarcoidosis (CS) by comparing CVB seropositivity in CS patients with available antibody testing at the University of Kansas Health System (2011–2025) to external comparator cohorts. The key finding was a high prevalence of CVB antibodies among patients with cardiac sarcoidosis (exact percentages truncated). Scientifically, this supports CVB as a potential infectious trigger or biomarker candidate in CS and may help improve early detection of cardiac involvement in sarcoidosis.
Donnelly KL, Wilmoth J, Osborne W et al. · Open heart · (2026) · View on PubMed ↗ · Free PDF ↗
Life-threatening ventricular arrhythmias in cardiac sarcoidosis with implantable devices: Incidence and predictors in a UK cohort.
This UK cohort study analyzed consecutive patients with cardiac sarcoidosis who received a cardiac implantable electronic device (CIED) between 2006 and 2024 to determine the incidence and predictors of life-threatening ventricular arrhythmias (VAs). It found that device-detected sustained VAs vary across guideline-based ICD indication categories defined by the 2014 Heart Rhythm Society (Class I, Class IIa, or Neither), and the study aimed to identify predictors of these events. The significance is that better prediction of sustained VA risk can refine ICD decision-making and sudden death prevention strategies in cardiac sarcoidosis.
Ahmed R, Behary Paray N, Azzu A et al. · Current problems in cardiology · (2026) · View on PubMed ↗
Hypertrophic Cardiomyopathy (HCM) & Prognostic Imaging
Dyssynchrony-Induced Cardiomyopathy in Children: Mechanisms, Diagnosis, and Contemporary Management.
This narrative review studied dyssynchrony-induced cardiomyopathy in children by synthesizing mechanisms, diagnostic criteria, and contemporary management strategies, emphasizing when electrical activation abnormalities drive reversible ventricular dysfunction. It concludes that dyssynchrony-induced cardiomyopathy is defined by sustained electrical activation abnormality with concordant mechanical dyssynchrony and adverse remodeling, with improvement after correction of the electrical substrate, with pediatric causality strongest for chronic right ventricular pacing and ventricular pre-excitation. Scientifically and clinically, the review provides a framework to distinguish causal dyssynchrony from secondary remodeling and to target electrical substrate correction to improve outcomes in pediatric patients.
Das BB, Singh HR · Pediatric cardiology · (2026) · View on PubMed ↗
Hypertrophic cardiomyopathy: state of the art on diagnosis and current therapeutic approach.
This article reviewed the state of the art in hypertrophic cardiomyopathy (HCM), emphasizing diagnosis, genetic testing, risk stratification, and current therapeutic approaches across the heterogeneous clinical spectrum. It consolidates how modern cardiovascular imaging and genetic evaluation refine phenotypic characterization and prognostic assessment for patients with HCM. The significance is a practical framework for clinicians to improve individualized management and surveillance, including sudden cardiac death risk assessment.
La Franca E, Parisi F, Lucchino A et al. · Cardiovascular ultrasound · (2026) · View on PubMed ↗ · Free PDF ↗
Left Atrium Myocardial Remodeling and Prognostic Marker Derived from CMR Feature Tracking in Pediatric Hypertrophic Cardiomyopathy.
This retrospective study examined left atrial (LA) myocardial remodeling and prognostic value of LA strain derived from cardiac magnetic resonance (CMR) feature tracking in pediatric patients with hypertrophic cardiomyopathy (HCM). Using CMR feature-tracking strain parameters and Cox regression analysis, it assessed whether LA strain is associated with adverse outcomes in children, extending prior adult evidence to a pediatric population. The significance is that CMR-FT–derived LA strain may serve as an early prognostic marker to improve risk stratification in pediatric HCM.
Chen X, Tang Y, Ma X et al. · Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · (2026) · View on PubMed ↗ · Free PDF ↗
Incretin Therapies & Sex-Specific Cardiometabolic Remodeling (Preclinical)
Anthracycline cardiotoxicity: role of metabolic vulnerability induced by cardiac pressure overload.
This preclinical study investigated how metabolic vulnerability interacts with cardiac pressure overload to influence anthracycline cardiotoxicity using two-month-old male and female Yucatan pigs subjected to aortic banding (left ventricular pressure overload) or sham surgery, followed by low-risk doxorubicin dosing. After four months, animals received five weekly intravenous injections of doxorubicin (1 mg/kg) or vehicle, creating groups including doxorubicin-only and banding-only conditions to test mechanistic links between pressure overload and doxorubicin injury (details truncated). The work is significant because it targets mechanistic drivers of anthracycline toxicity—potentially enabling risk stratification and metabolic-based cardioprotective therapies in patients with hypertension or valvular disease.
Galán-Arriola C, Pérez-Camargo D, Jorge I et al. · European heart journal · (2026) · 7 citations · View on PubMed ↗ · Free PDF ↗
Cardiovascular Effects of Chronic GIPR and GLP-1R Agonism in Lean and Diet-Induced Obese Mice: Sex Differences and Dose-Dependent Remodeling.
In lean and diet-induced obese male and female mice, this study used continuous 1-month infusion of a GIP receptor (GIPR) agonist or GLP-1 receptor (GLP-1R) agonist at multiple doses to define short-term cardiovascular effects and sex-specific cardiac remodeling patterns. The key finding was that GIPR versus GLP-1R agonism produced distinct, sex-dependent remodeling responses in the heart under both chow and diet-induced obesity conditions. These results inform how incretin-pathway therapies may differentially affect cardiovascular structure/function across sexes and metabolic states.
Göktaş SŞ, Francisco A, Duarte JMN et al. · American journal of physiology. Heart and circulatory physiology · (2026) · View on PubMed ↗ · Free PDF ↗
Myocardial Infarction Remodeling & CMR Risk Stratification
Long-Term Warranty Period of Stress CMR and SPECT in Stable Angina: Implications for Repeat Testing.
This study analyzed long-term prognostic value and operational “warranty periods” for normal results of stress cardiac magnetic resonance (CMR) versus single-photon emission computed tomography (SPECT) in stable angina, building on the CE-MARC trial cohort of 752 patients. The key aim was to compare long-term outcomes after normal functional imaging and to determine how long a normal stress CMR or SPECT result remains reassuring (methods and results truncated). Clinically, establishing warranty periods can guide repeat testing intervals and reduce unnecessary imaging while maintaining safe prognostic surveillance.
Bisaccia G, Swoboda PP, Younger JF et al. · JACC. Cardiovascular imaging · (2026) · View on PubMed ↗
Right Atrial Cardiomyopathy Assessed by Late Gadolinium Enhancement Cardiac MRI Following Pulmonary Vein Isolation in Patients with Atrial Fibrillation.
This prospective imaging study assessed right atrial (RA) tissue remodeling in atrial fibrillation (AF) patients before and after pulmonary vein isolation (PVI) using 3D late gadolinium enhancement cardiac MRI (LGE-CMR). In 54 AF patients (baseline and 3 months post-PVI) with 18 healthy volunteers as controls, RA-LGE was quantified with intensity-threshold categories (>1.20 total LGE, 1.20–1.32 border-zone, >1.32 dense LGE), and one-year AF recurrence was evaluated (results truncated). The significance is that 3D LGE-CMR may provide tissue-level markers of reverse RA remodeling after PVI, potentially linking imaging changes to recurrence risk.
van Pouderoijen N, Hopman LHGA, Post M et al. · Heart rhythm · (2026) · View on PubMed ↗ · Free PDF ↗
Traditional left ventricular indices outperform novel cardiovascular magnetic resonance-derived left atrial parameters in predicting adverse left ventricular remodelling after ST-segment elevation myocardial infarction.
In a post-hoc analysis of the EURO-ICE trial (n=200) of anterior ST-segment elevation myocardial infarction (STEMI), the investigators compared prognostic performance of conventional left ventricular (LV) indices versus novel cardiac magnetic resonance (CMR)-derived left atrial (LA) parameters (including LA strain and left atrioventricular coupling index, LACI) for early adverse LV remodeling. Traditional LV indices outperformed the CMR-derived LA parameters in predicting early adverse LV remodeling. Clinically, this suggests that routine LV functional measures may be more reliable than LA-derived CMR metrics for early risk stratification after anterior STEMI.
Yosofi B, Zelis JM, Raafs A et al. · International journal of cardiology · (2026) · 1 citations · View on PubMed ↗ · Free PDF ↗
Adult Congenital Heart Disease (Repaired TOF) & Long-Term Surveillance
Physiological rather than pathological cardiac remodeling in olympic-style elite weightlifters: an imaging and biomarker study.
This cross-sectional imaging and biomarker study investigated whether long-term Olympic-style resistance training produces physiological rather than pathological cardiac remodeling in 13 elite male weightlifters (≥5 years experience) versus 13 age-matched healthy controls. Using echocardiographic longitudinal strain and cardiac MRI metrics (native T1, extracellular volume [ECV], and late gadolinium enhancement [LGE]) alongside serum biomarkers (including galectin-3, soluble ST2, TNF-α, endothelin-1, TGF-β, and cardiac troponin), the study tested for maladaptive fibrosis signals (results truncated). The clinical significance is that it helps distinguish adaptive athlete’s heart from early pathological remodeling that could predispose to cardiomyopathy.
Yargic MP, Akin S, Duzgun SA et al. · European journal of applied physiology · (2026) · View on PubMed ↗
Right ventricular-pulmonary arterial coupling in transfusion-dependent thalassemia: a cross-sectional cardiac MRI study.
This cross-sectional cardiac MRI study evaluated right ventricle–pulmonary artery coupling (RVPAc) in transfusion-dependent thalassemia (TDT) and its associations with demographics, clinical variables, MRI findings, and heart failure. Using the E-MIOT project, the authors analyzed 1154 consecutive TDT patients and compared them with 167 age- and sex-matched healthy controls, calculating RVPAc as a ratio of right ventricular and pulmonary artery measures (details truncated). The significance is that RVPAc could serve as an imaging biomarker for cardiopulmonary dysfunction in TDT, supporting earlier identification of patients at risk for heart failure.
Meloni A, Saba L, Pistoia L et al. · European radiology · (2026) · View on PubMed ↗
Repaired tetralogy of Fallot across adulthood: from right ventricular remodelling to targeted intervention.
This review synthesized current evidence on adults with repaired tetralogy of Fallot (rTOF), focusing on mechanisms driving progressive right ventricular (RV) dilatation, dysfunction, dyssynchrony, and myocardial fibrosis due to chronic pulmonary regurgitation and/or residual right ventricular outflow tract obstruction. It highlights multimodality imaging, pulmonary valve replacement (PVR), arrhythmia risk stratification, and aortopathy surveillance, along with emerging pharmacologic approaches, as key components of contemporary management. The clinical significance is improved long-term surveillance and targeted intervention to prevent heart failure and ventricular arrhythmias in the growing rTOF adult population.
Cienkowski K, Moll M, Cienkowska A et al. · Heart failure reviews · (2026) · View on PubMed ↗ · Free PDF ↗
Post–Acute Ischemic Stroke Cardiac Rhythm/Conduction Surveillance
Sex Differences in Cardiac Rhythm and Conduction Abnormalities After Noncardioembolic Ischemic Stroke.
This study screened 673 patients (39% women) with first noncardioembolic acute ischemic stroke (AIS) and no prior cardiac disease at a tertiary stroke center to assess sex-specific newly diagnosed cardiac rhythm and conduction abnormalities within 1 year. Women and men differed in the incidence/pattern of post-AIS cardiac rhythm/conduction abnormalities despite standardized post-stroke cardiac evaluation including 24-hour in-hospital telemetry, 24-hour blood pressure monitoring, and echocardiography. These findings support sex-tailored cardiovascular surveillance after noncardioembolic AIS to improve early detection of clinically relevant arrhythmia/conduction complications.
Schmick A, Rohner MH, Gebhard C et al. · Journal of the American Heart Association · (2026) · View on PubMed ↗ · Free PDF ↗
Microvascular Dysfunction & Invasive Hemodynamic Markers in MI
Pre-perfusion coronary wedge pressure and microvascular obstruction in anterior ST elevation myocardial infarction (STEMI): An analysis from the EUROICE study.
Using data from the EURO-ICE study, this analysis evaluated whether pre-perfusion coronary wedge pressure (CWP) measured during balloon occlusion predicts microvascular obstruction (MVO) on cardiac magnetic resonance (CMR) and relates to adverse left ventricular (LV) remodeling in anterior STEMI patients undergoing timely primary percutaneous coronary intervention (PPCI). Pre-perfusion CWP provided additional insight into microvascular compromise occurring during coronary occlusion, complementing post-reperfusion invasive indices such as index of microvascular resistance (IMR). This supports CWP as a practical invasive marker to better identify patients at risk for MVO and subsequent LV remodeling even when reperfusion has already occurred.
Butt H, van Beek K, Sajjad U et al. · International journal of cardiology · (2026) · View on PubMed ↗
Right-Sided Valvular Disease (Tricuspid Regurgitation) & RV Remodeling Trials
Effect of empagliflozin with or without carvedilol on tricuspid regurgitation and right ventricular remodeling: PROVE trial.
In the PROVE randomized 2×2 factorial trial (n=56) enrolling patients with significant functional tricuspid regurgitation (TR), investigators tested sustained-release carvedilol (carvedilol SR), empagliflozin, or their combination for effects on right ventricular (RV) remodeling and TR severity over 12 months. The trial assessed whether these therapies reduced RV end-systolic volume index and improved TR by breaking the TR–RV remodeling vicious cycle. If effective, this would provide an evidence-based medical strategy to reverse RV remodeling and reduce TR progression in patients with functional TR.
Kim GY, Lim SM, Yang DH et al. · Journal of cardiovascular imaging · (2026) · View on PubMed ↗ · Free PDF ↗
Cardiac Immunity, Viral Latency, and Post-MI Repair (Preclinical)
Cytomegalovirus Latency Fuels Inflammation Following Myocardial Infarction.
This study used C57BL/6J mice with latent murine cytomegalovirus (CMV) infection to determine how latency alters cardiac immune cell dynamics at baseline and during post-myocardial infarction (MI) repair. Latent CMV promoted inflammation after MI by reshaping immune cell responses, supported by spectral flow cytometry and bulk/single-cell RNA/T-cell receptor (TCR) sequencing. Mechanistically, it links CMV latency to impaired post-MI repair, providing a potential targetable pathway for improving outcomes after MI.
Dapergola E, Šustić M, Ashour D et al. · Circulation research · (2026) · View on PubMed ↗ · Free PDF ↗
Associations between accelerometer-measured physical activity, sedentary behaviour and pericardial adiposity: a prospective cohort study of UK Biobank participants.
In a prospective UK Biobank cohort of 16,685 participants with cardiac magnetic resonance assessment and wrist-worn triaxial accelerometer data, the study examined associations between objectively measured physical activity (light, moderate, vigorous) and sedentary behavior with pericardial adiposity. Physical activity levels were associated with pericardial fat measures, with sedentary behavior showing an adverse relationship after multivariable adjustment. This supports using accelerometer-derived activity and sedentary metrics to identify individuals at risk for increased pericardial adiposity, a potential cardiovascular risk marker.
Yang W, Chen Z, Li S et al. · BMJ public health · (2026) · View on PubMed ↗ · Free PDF ↗
Cardiac Tumors & Rare Masses (Imaging Case Reports)
Imaging features of right atrial lipoma on multimodality imaging: A case report.
This case report studied multimodality imaging findings of a right atrial cardiac lipoma in a 53-year-old asymptomatic female. Transthoracic echocardiography identified a mass at the junction of the superior vena cava and the right atrium, with further characterization pursued using transesophageal echocardiography and additional imaging modalities. Recognizing the variable morphology of right atrial lipomas on multimodality imaging can improve diagnostic accuracy and guide appropriate management of this rare benign primary cardiac tumor.
Xie Q, Fang A, Chen X et al. · Medicine · (2026) · View on PubMed ↗ · Free PDF ↗
Biosensors & Noninvasive Metabolic Detection
Machine learning-assisted optimization of a BK7/Ag/As₂S₃/graphene surface plasmon resonance biosensor for high-sensitivity urine glucose detection.
This study investigated a theoretically optimized multilayer surface plasmon resonance (SPR) biosensor (BK7/Ag/As2S3/graphene) for non-invasive urine glucose detection at 633 nm, using electromagnetic optimization and a Gradient Boosting Regressor (GBR) predictive framework. The key finding was that incorporating an ultrathin As2S3 dielectric spacer and a graphene sensing layer with systematic SPR optimization enabled high-sensitivity glucose detection in urine. Scientifically, this supports a pathway to more stable, non-enzymatic/less enzyme-dependent glucose sensing compared with conventional electrochemical approaches.
Arun Kumar U, Alavudeen Basha A, Elshafie H et al. · Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy · (2026) · View on PubMed ↗ · Free PDF ↗
Generated automatically on September 18, 2026. Covers PubMed articles published September 11, 2026 – September 18, 2026. Summaries are AI-generated; always consult the original publication for clinical or research decisions.