What's New in Cardiac MRI? — September 25, 2026
AI-summarised digest of 62 PubMed articles on Cardiac MRI published in the last 7 days.
Jump to category
What’s New in Cardiac MRI?
September 25, 2026 · 62 articles · 15 research themes · covering September 18, 2026 – September 25, 2026
Overview
Across this week’s set, cardiac MRI (CMR) is repeatedly positioned as a mechanistic bridge between systemic disease processes and patient-level outcomes. Large cohort work links chronic inflammation—quantified via NMR metabolomics/proteomics markers such as GlycA—and genetic/environmental context to CMR-defined cardiac remodeling and cardiovascular risk. Complementing this, CMR-based tissue characterization (native T1/T2, ECV, and LGE) is used to detect subclinical myocardial injury in inflammatory and autoimmune settings (e.g., SLE with Sjögren’s syndrome) and in cardio-metabolic disease (glycemic markers, type 2 diabetes, and macroalbuminuria with CKD), emphasizing that early structural/functional changes can refine risk beyond traditional clinical measures.
A second dominant theme is improved risk stratification for arrhythmias and remodeling using CMR-derived substrates and multimodality integration. Multiple studies highlight the prognostic value of LGE patterns—septal NI-LGE after MI, LGE burden in mitral valve prolapse, and CMR–FDG PET/CT phenotypes in myocarditis—to better identify patients at higher risk for heart failure progression or ventricular arrhythmias. In non-ischemic cardiomyopathy, frameworks that integrate CMR with electrophysiology and genetics aim to reduce unnecessary ICD implantation while improving sudden cardiac death prevention. Novel CMR approaches (e.g., strain-rate tensor field concepts, hemodynamic flow-force frameworks, and geometric-morphological metrics) further suggest that moving beyond conventional strain/LGE toward physics-informed or geometry-informed biomarkers may enable earlier detection of adverse remodeling.
Finally, the collection underscores the expanding diagnostic frontier of CMR in complex cardiomyopathies—especially genetic cardiomyopathies and amyloidosis. Case reports and cohorts show how variant reclassification (e.g., DSP cardiomyopathy), phenotypic transitions (e.g., Danon to arrhythmogenic cardiomyopathy), and amyloid “mimics” (ATTR/AL and rarer subtypes, including localized amyloidoma and false-negative radionuclide patterns) can change diagnosis and management. Alongside this, computational and acquisition innovations—contrast dose optimization, fetal MRI reconstruction pipelines, and deep-learning segmentation/biomarker extraction—signal a parallel push toward faster, more reproducible imaging workflows that can scale these advanced phenotyping strategies in routine care.
Genetic cardiomyopathies & variant reclassification
Myocarditis-Like Presentation Leads to DSP Arrhythmogenic Cardiomyopathy Diagnosis: From Variant of Uncertain Significance to Diagnosis.
This case report studied a 38-year-old woman with suspected arrhythmogenic cardiomyopathy who had myocarditis-like symptoms and underwent cardiac magnetic resonance (CMR) and genetic testing. Initial testing found a desmoplakin (DSP) variant of uncertain significance (VUS) and follow-up CMR showed persistent multifocal nonischemic late gadolinium enhancement, after which the DSP variant was reclassified as likely pathogenic to establish DSP cardiomyopathy. The report highlights that reclassification of cardiomyopathy gene variants (DSP) can directly change diagnosis and management in patients presenting with myocarditis-like findings.
DeLorenzo O, Farkouh F, Alameh I et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗
Phenotypic Transition From Danon Disease to Arrhythmogenic Cardiomyopathy: Multimodality and Histopathologic Evidence.
This case report studied a phenotypic transition in a 30-year-old woman from Danon disease (LAMP2 gene–related) to arrhythmogenic cardiomyopathy. The key finding was that multimodality cardiac MRI showed extensive ring-like late gadolinium enhancement with biventricular systolic dysfunction consistent with arrhythmogenic cardiomyopathy, supported by histopathologic evidence. The clinical significance is that LAMP2-associated disease can evolve into an arrhythmogenic phenotype, which has implications for long-term surveillance and management of ventricular arrhythmias.
Quintella Sangiorgi Olivetti N, Belitardo GP, Cerqueira Matheus F et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗
Fulminant Biventricular Desmoplakin Cardiomyopathy With a Myocarditis-Like Presentation.
This JACC Case Reports article described a 23-year-old man with fulminant biventricular desmoplakin (DSP) cardiomyopathy presenting with a myocarditis-like illness after months of intermittent fever. Whole-exome sequencing identified a likely pathogenic DSP variant, and cardiac MRI showed extensive circumferential subepicardial ring-like fibrosis with severe biventricular systolic dysfunction. The significance is that DSP cardiomyopathy can mimic myocarditis, so early genetic testing and appropriate risk stratification are crucial when inflammatory causes are excluded.
Byreddi B, Kumar P, Imayavaramban B et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗
Contrast agents & CMR acquisition optimization
Gadopiclenol for Cardiac MRI: Comparison of Myocardial T1 Relaxation Times and Subjective Image Quality at Different Doses in Patients With Anderson-Fabry Disease.
This observational feasibility study evaluated gadopiclenol dosing in 3T cardiac MRI in patients with Anderson-Fabry disease (AFD), comparing myocardial T1 relaxation times and subjective late gadolinium enhancement (LGE) image quality across two contrast doses. Gadopiclenol produced myocardial T1 shortening consistent with its high relaxivity and yielded LGE image quality comparable to expectations while using reduced gadolinium dose. The findings support gadopiclenol as a potentially effective lower-dose contrast agent for cardiac MRI in AFD, pending broader validation.
Kollmann AT, Huflage H, Dazeh RS et al. · Investigative radiology · (2026) · View on PubMed ↗
CT-derived myocardial extracellular volume: current evidence, clinical utility, and the emerging role of photon-counting CT-a systematic review.
This PRISMA-compliant systematic review evaluated current evidence and clinical utility for CT-derived myocardial extracellular volume (ECV), focusing on its role as an alternative to cardiac magnetic resonance (CMR) ECV reference standards. It synthesized data from studies up to December 2025 on how CT ECV is measured and how well it agrees with CMR, highlighting emerging applications and limitations. If validated across protocols, CT-derived ECV could enable broader, routine assessment of diffuse myocardial fibrosis using widely available cardiac CT.
D’Argenzio J, Stucchi F, Tambè V et al. · European radiology experimental · (2026) · View on PubMed ↗ · Free PDF ↗
Inflammatory/immune-mediated conduction disease
Complete Atrioventricular Block in an HLA-B27-Positive Woman Without Overt Spondyloarthritis.
This case report studied a 43-year-old HLA-B27-positive woman without overt spondyloarthritis who presented with symptomatic complete atrioventricular block (CAVB) requiring dual-chamber pacemaker implantation. Despite the absence of clinical spondyloarthritis, the workup using cardiac magnetic resonance, fluorodeoxyglucose positron emission tomography, and comprehensive genetic testing supported an inflammatory/conduction association in the setting of recurrent HLA-B27-positive anterior uveitis and autoimmune comorbidities (Hashimoto thyroiditis). The case underscores that HLA-B27-associated conduction disease can present as isolated CAVB even without overt spondyloarthritis, informing diagnostic evaluation in younger adults.
Batista Lage JG, Tavares Pinheiro MV, Ferreira de Souza O et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗
Multimodality imaging for rare structural coronary anomalies
Complex bilateral coronary artery fistulas with multiple drainage sites: a multimodality imaging case report.
This multimodality imaging case report studied a 68-year-old patient with exertional dyspnea and dizziness in whom coronary artery fistulas (CAFs) were evaluated using coronary angiography and multislice computed tomography. Imaging demonstrated complex bilateral CAFs arising from both coronary arteries with multiple drainage sites including the superior vena cava, right atrium, and descending aorta. The report illustrates how combined anatomic and physiologic imaging can characterize highly complex CAF anatomy to guide management decisions.
Ružičić D, Čanković M, Komazec N et al. · European heart journal. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗
Multidisciplinary single stage surgical management of advanced breast carcinoma with concomitant left atrial myxoma.
This case report described multidisciplinary single-stage surgical management of a 58-year-old woman with locally advanced invasive mucinous breast carcinoma and a concomitant left atrial myxoma. Echocardiography incidentally found a left atrial mass, while cardiac MRI and FDG PET-CT suggested a cardiac neoplasm but could not exclude metastasis, prompting surgical decision-making that addressed both malignancy context and embolic risk. The report highlights how integrated imaging and coordinated surgery can manage rare co-occurrence of atrial myxoma with active breast cancer.
Haval S, Garg A, Pawar R et al. · Interdisciplinary cardiovascular and thoracic surgery · (2026) · View on PubMed ↗ · Free PDF ↗
Presumed Primary Cardiac Angiosarcoma With Atrioventricular Groove Rupture and Right Coronary Artery Compromise: A Case Report and Literature Review.
This case report and literature review evaluated a patient with presumed primary cardiac angiosarcoma presenting with hemorrhagic pericardial effusion and an atrioventricular groove lesion causing rupture and right coronary artery compromise. The key finding was that multimodality imaging enabled recognition of the mechanism of catastrophic complication and supported emergency salvage surgery when complete resection was unlikely. Clinically, it emphasizes early multidisciplinary planning and rapid surgical decision-making in suspected cardiac angiosarcoma with groove involvement and coronary compromise.
Akbari F, Parvizi R, Mobadersani M et al. · Clinical case reports · (2026) · View on PubMed ↗ · Free PDF ↗
Novel CMR methods for myocardial mechanics/remodeling
Strain Rate Angle Distribution as an Indicator of Post-Infarct Myocardial Remodeling: Proof-of-Concept of a Novel Application of the MRI Derived Strain Rate Tensor Field.
This proof-of-concept study investigated a novel MRI-derived strain rate tensor field approach—specifically strain rate angle distribution—as an indicator of post-infarct myocardial remodeling in a rat model of myocardial infarction (MI). Using velocity-encoded MRI with tissue phase mapping (TPM) to compute strain rate tensors, the authors showed that strain rate angle distribution can capture multidirectional deformation changes associated with remodeling. The technique could improve in vivo assessment of LV remodeling beyond conventional strain metrics, potentially enhancing translational risk monitoring after MI.
Totland L, Bendiksen BA, Nordén ES et al. · Magnetic resonance in medicine · (2026) · View on PubMed ↗ · Free PDF ↗
Growth of Cardiac Fibromas During Infancy.
This retrospective single-center study investigated the natural history of cardiac fibromas by measuring growth in 36 infants and children using serial cardiovascular magnetic resonance (CMR) and/or cardiac computed tomography (CT), including cases before and after surgery. Contrary to the historical assumption of stability, the study found that unoperated cardiac fibromas can increase in size during infancy/childhood. The results have clinical significance for surveillance strategies and risk assessment of arrhythmia and hemodynamic complications in pediatric fibroma patients.
Jurow K, Sperotto F, Geva T et al. · Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · (2026) · View on PubMed ↗ · Free PDF ↗
Peripartum cardiomyopathy presenting as postpartum cardiogenic shock: a multimodality imaging approach.
This case report studied peripartum cardiomyopathy presenting as postpartum cardiogenic shock in a peripartum patient, emphasizing rapid exclusion of alternative causes. The key finding was that a multimodality imaging approach using computed tomography and cardiac magnetic resonance helped characterize the acute heart failure etiology in the peripartum setting. The scientific/clinical significance is that combining CT and CMR can improve diagnostic speed and accuracy when postpartum cardiogenic shock requires urgent differential diagnosis.
Pretelt ECG, Romanque P, Alegría Bobadilla J et al. · The international journal of cardiovascular imaging · (2026) · View on PubMed ↗
Absolute myocardial mass difference and ventriculo-arterial coupling in morphologically defined left ventricular non-compaction: A multiparametric cardiovascular magnetic resonance study.
This retrospective multiparametric CMR study investigated whether absolute myocardial mass difference (AD) reflects structural-functional remodeling in morphologically defined left ventricular non-compaction (LVNC) and how it relates to hemodynamic and flow-related parameters. Among 99 LVNC patients meeting Petersen and Grothoff CMR criteria and 66 matched controls, AD was evaluated alongside ventriculo-arterial coupling and other CMR-derived hemodynamic/flow measures to determine associations with dynamic adaptation rather than static morphology alone. If confirmed, AD could improve CMR phenotyping of LVNC by linking morphology to functional/hemodynamic consequences relevant to prognosis and management.
Bulut SSD, Emir SN · Acta radiologica (Stockholm, Sweden : 1987) · (2026) · View on PubMed ↗
β-hydroxy-β-methylbutyrate improves fast-twitch muscle function, histopathology and mitochondrial respiration in the D2.mdx dystrophic mouse.
This study tested whether 8 weeks of supplementation with the leucine metabolite β-hydroxy-β-methylbutyrate (HMB) improves muscle outcomes in D2.mdx dystrophic mice, a dystrophin-deficient model of Duchenne muscular dystrophy (DMD). HMB improved fast-twitch muscle function and histopathology and enhanced mitochondrial respiration compared with untreated dystrophic controls. These findings support HMB as a potential mitochondria-targeted adjunct therapy for DMD, with relevance strengthened by evaluation beyond the earlier juvenile mdx peak-damage window.
Giourmas N, Lalunio H, Calzoni M et al. · The Journal of physiology · (2026) · View on PubMed ↗ · Free PDF ↗
Myocardial Strain Evaluation from Cardiovascular MRI and CT: Physiological Principles and Clinical Perspectives.
This review article synthesized the physiological principles and clinical perspectives of measuring myocardial deformation (strain) using cardiovascular MRI (CMR) and cardiac CT (CCT). The key finding is that strain provides locally specific, physiology-linked markers of myocardial function that can complement or outperform global indices in detecting and characterizing cardiac disease. Clinically, it frames how CMR- and CT-based strain techniques may improve diagnosis, monitoring, and outcome prediction across cardiovascular conditions.
Hussein TM, Pourmorteza A, Oshinski JN · The British journal of radiology · (2026) · View on PubMed ↗
Post-myocardial infarction remodeling & hemodynamic forces
Septal Nonischemic Late Gadolinium Enhancement After Myocardial Infarction Is Associated With Adverse Remodeling and Improves Risk Stratification for Heart Failure Outcomes.
This retrospective cohort study analyzed 948 patients with prior myocardial infarction on cardiac magnetic resonance (excluding coexisting myocarditis or nonischemic cardiomyopathies) to assess prognostic value of septal nonischemic late gadolinium enhancement (NI-LGE). NI-LGE, defined as midwall or subepicardial enhancement, was associated with adverse cardiac remodeling and improved risk stratification for heart failure outcomes using competing-risk analysis. The results support septal NI-LGE as a clinically actionable CMR marker for identifying post-MI patients at higher risk of heart failure progression.
Zhou P, Zhao K, Aisikaier K et al. · Journal of the American Heart Association · (2026) · View on PubMed ↗ · Free PDF ↗
Giant Coronary Artery Aneurysms and Severe Biventricular Failure: Multimodality Imaging-Guided Conservative Management.
This JACC case report studied a 35-year-old man with acute heart failure and severe biventricular dysfunction in whom giant multivessel coronary artery aneurysms with mural thrombi were evaluated using multimodality imaging. Cardiac MRI showed transmural late gadolinium enhancement confined to the anterior and lateral walls with partial recovery of biventricular function, and the patient was managed conservatively guided by imaging findings. The case suggests that imaging-defined extent of myocardial injury and functional recovery may support conservative management in selected patients with giant coronary artery aneurysms.
Davila Flores D, Pitta Acevedo M, Vargas Cabrera O et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗
Hemodynamic forces provide incremental predictive value for left ventricular remodeling after STEMI.
This study assessed whether cardiac MRI-derived hemodynamic forces (HDF) add prognostic value for adverse left ventricular remodeling (ALVR) after ST-segment elevation myocardial infarction (STEMI). In 147 STEMI patients scanned by CMR within 7 days and again at 5 months post–percutaneous coronary intervention (PCI), ALVR was defined as a ≥15% increase in left ventricular end-systolic volume, and multivariable models tested baseline clinical, conventional CMR, strain, and HDF predictors. The findings indicate that HDF parameters can incrementally predict ALVR beyond conventional risk markers, potentially enabling earlier identification of patients at risk for post-MI remodeling.
Hu M, Yue X, Chen Y et al. · Magnetic resonance imaging · (2026) · View on PubMed ↗
Diabetes, kidney disease, and cardio-renal remodeling assessed by CMR
Glycemic Status, Cardiac Structure, and Function by Magnetic Resonance Imaging: The Jackson Heart Study.
This analysis within the Jackson Heart Study evaluated associations between glycemic status markers and cardiac structure/function measured by cardiac magnetic resonance in Black adults. Using CMR-derived measures including Eulerian peak systolic circumferential strain, LV mass, volumes, ejection fraction, and a LV remodeling index, the study linked glycemic markers to LV remodeling patterns indicative of subclinical dysfunction. The findings support CMR-based phenotyping of early myocardial changes across glycemic states in a high-risk population.
Kaze AD, Ani C, Fox ER et al. · Journal of the American Heart Association · (2026) · 1 citations · View on PubMed ↗ · Free PDF ↗
Impact of type 2 diabetes on myocardial mechanics, fibrosis, and prognosis in hypertrophic cardiomyopathy: A cardiac magnetic resonance study.
This retrospective CMR cohort study assessed how coexisting type 2 diabetes mellitus (T2DM) affects myocardial mechanics, fibrosis, and prognosis in 582 hypertrophic cardiomyopathy (HCM) patients (127 with T2DM, 455 without). T2DM was associated with worse CMR-derived myocardial mechanics and greater fibrosis burden, and mediation analysis suggested CMR parameters helped explain the HbA1c–outcome relationship. These findings support using CMR biomarkers to refine risk stratification and management intensity in HCM patients with T2DM.
Cao Y, Li Y, Ming Z et al. · International journal of cardiology · (2026) · View on PubMed ↗
Navigating coronary microvascular dysfunction: an echocardiographic triage algorithm for cardiac magnetic resonance and coronary computed tomography angiography.
This study proposed an echocardiography-guided triage algorithm to noninvasively detect coronary microvascular dysfunction (CMD) and route selected patients to definitive cardiac magnetic resonance (CMR) and coronary CT angiography (CCTA). Using transthoracic echocardiography with global longitudinal strain (GLS) and a Doppler-derived coronary sinus flow (CSF) index as the initial screen, patients with abnormal results were referred for CMR for tissue characterization and quantitative phase assessment. The algorithm’s goal is earlier CMD detection and improved risk stratification without relying on invasive testing for all patients.
Güleşir ME · Journal of ultrasound · (2026) · View on PubMed ↗
Macroalbuminuria as a marker of cardiac damage in patients with type 2 diabetes: insights from multimodality cardiac imaging and biomarkers.
This cross-sectional multimodality study assessed whether macroalbuminuria is associated with cardiac structure and function in 49 adults with type 2 diabetes (T2D) and stage 3 chronic kidney disease (CKD), compared with 20 controls, using cardiac MRI, transthoracic echocardiography (TTE), and nine serum biomarkers including soluble suppression of tumorigenicity 2 (sST2). Patients with macroalbuminuria showed worse cardiac injury/stress profiles, with biomarker patterns (including sST2-related myocardial stress/fibrosis signaling) aligning with adverse cardiac imaging findings. The results support macroalbuminuria as a clinically useful marker of subclinical cardiac damage in T2D with CKD, informing cardiovascular risk assessment beyond renal outcomes.
Olloquiegui XI, Andueza SE, Izco MP et al. · Journal of physiology and biochemistry · (2026) · View on PubMed ↗ · Free PDF ↗
Left ventricular remodeling by cardiac magnetic resonance in children with advanced chronic kidney disease: an analysis of the Chronic Kidney Disease in Children (CKiD) study.
This exploratory analysis of the Chronic Kidney Disease in Children (CKiD) study used cardiac MRI (CMR) to characterize left ventricular remodeling and myocardial strain in children with advanced chronic kidney disease (CKD). The study related CMR-derived measures of myocardial morphology/function to CKD severity, showing that advanced CKD is associated with adverse LV remodeling and abnormal strain patterns. These data strengthen the case for CMR as a sensitive tool for early detection of cardiovascular involvement in pediatric CKD, potentially guiding monitoring and risk reduction.
Reyes LZ, Roem J, Lang SM et al. · Pediatric nephrology (Berlin, Germany) · (2026) · View on PubMed ↗ · Free PDF ↗
Associations of CMR-based pulse wave velocity and aortic distensibility with infrarenal ultrasound-based aortic parameters in the Hamburg City Health Study.
Using data from the Hamburg City Health Study, this study assessed whether cardiac MRI-derived pulse wave velocity (PWV) and aortic distensibility (AD) relate to infrarenal abdominal aortic aneurysm (AAA) risk markers measured by ultrasound. PWV and AD of the ascending and descending aorta were quantified with 2D phase-contrast velocity-encoding CMR, while ultrasound measured infrarenal aortic maximum diameter and peak flow velocity to classify ectasia (25–29 mm) and aneurysm (≥30 mm). The results support CMR vascular stiffness metrics as potential screening and cardiovascular risk stratification tools for infrarenal aortic disease.
Riedl KA, Di Carluccio E, Lund G et al. · Clinical research in cardiology : official journal of the German Cardiac Society · (2026) · View on PubMed ↗ · Free PDF ↗
Echocardiographic Trajectories of Right Ventricular Size and Function in Children Following Tetralogy of Fallot Repair: A Decade of Stability.
This single-center retrospective cohort study evaluated echocardiographic trajectories of right ventricular (RV) size and function over the first 10 years after tetralogy of Fallot repair (TOFr) in children. By analyzing serial echocardiograms obtained at least one year apart for patients repaired between 3/2012 and 12/2023, the investigators tested the hypothesis that RV remodeling remains relatively stable throughout childhood despite pulmonary regurgitation–related volume overload. The decade-long stability characterization can inform surveillance strategies and timing of interventions for RV dysfunction in pediatric TOF survivors.
Galan JA, Jones AL, Numata R et al. · Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography · (2026) · View on PubMed ↗
Cardiac involvement in neurofibromatosis type 1: real-world baseline and follow-up findings from a tertiary single-center cohort.
This tertiary single-center cohort study assessed cardiac involvement in 114 pediatric patients with neurofibromatosis type 1 (NF1) using ECG, echocardiography, and blood pressure measurement, with Holter ECG and cardiac MRI performed when indicated. The study found that cardiac abnormalities were common at baseline (30.7% on initial evaluation after excluding isolated patent findings) and characterized a spectrum of abnormalities associated with demographic/clinical factors. Scientifically and clinically, it provides real-world baseline and follow-up data to support cardiac surveillance strategies in children with NF1.
Öz Yıldız S, İmanlı M, Aykan HH et al. · European journal of pediatrics · (2026) · View on PubMed ↗
CMR risk stratification in hypertrophic cardiomyopathy (HCM)
Vascular changes in hypertrophic cardiomyopathy.
This review summarized evidence on vascular changes in hypertrophic cardiomyopathy (HCM), focusing on both microvascular dysfunction and structural vascular remodeling. It synthesized modalities used to assess vascular function (including cardiac and peripheral vascular assessments) and related these vascular abnormalities to fibrosis, disease progression, and clinical outcomes. The review highlights the mechanistic and prognostic importance of vascular pathology in HCM and frames how vascular imaging/function tests may complement standard cardiac evaluation.
Visch JE, Nassar A, Burchell G et al. · Cardiovascular research · (2026) · View on PubMed ↗ · Free PDF ↗
Prognostic significance of cardiac magnetic resonance parameters in hypertrophic cardiomyopathy: a multicentre study.
This multicentre retrospective study evaluated prognostic CMR parameters in hypertrophic cardiomyopathy (HCM) patients by comparing left ventricular global longitudinal strain (LVGLS), left atrial strain (LAS), and late gadolinium enhancement (LGE) for prediction of major adverse cardiac events (MACE). Using CMR feature-tracking (FT) for LV strain and LAS and LGE quantification, the investigators identified independent CMR predictors of MACE among HCM patients scanned between 2008 and 2022 across five sites. If validated, these CMR-derived functional and fibrosis markers could improve risk stratification for heart failure, arrhythmias, and sudden cardiac death in HCM.
Ho SY, Yiu K, Leung KH et al. · The international journal of cardiovascular imaging · (2026) · View on PubMed ↗ · Free PDF ↗
Cardiac amyloidosis diagnosis, phenotyping, and treatment (multimodality)
Obstructive Intramural Coronary Amyloidosis: Uncommon or Under-Recognized Cause of Microvascular Angina?
This case studied an 83-year-old man with long-standing angina and persistently elevated troponin but normal coronary angiography, to evaluate obstructive intramural coronary amyloidosis (OICA) as a cause of microvascular angina. Endomyocardial biopsy demonstrated extensive transthyretin (TTR) amyloid deposition almost exclusively within intramural coronary arterioles, establishing OICA as the mechanism of his ischemic symptoms. The report highlights that TTR OICA can be an under-recognized, biopsy-confirmable cause of microvascular angina-like presentations despite negative noninvasive cardiac amyloid testing.
Fazzini L, D’Elia E, Sciatti E et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗
Epicardial Amyloidoma Mimicking Secondary Cardiac Lymphoma: A Sneeze Away From the Diagnosis.
This case studied a man with indolent B-cell lymphoma and monoclonal gammopathy to determine whether an epicardial cardiac mass represented malignancy versus localized amyloid deposition (amyloidoma). Multimodality imaging (cardiac MRI with marked enhancement and increased extracellular volume, plus nondiagnostic PET and bone scintigraphy) suggested secondary cardiac lymphoma or Erdheim-Chester disease, but surgical biopsy with Congo red staining identified epicardial amyloidoma. The findings emphasize that localized cardiac amyloid deposition can closely mimic secondary cardiac lymphoma, requiring tissue diagnosis to avoid misclassification.
Vella A, Disabato G, Roncoroni L et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗
Apolipoprotein A-IV Cardiac Amyloidosis as a Diagnostic Pitfall: Beyond the Noninvasive Algorithm.
This case studied a 71-year-old man with reduced kidney function and heart failure with concentric LV hypertrophy and an apical-sparing strain pattern to identify the amyloid type when standard noninvasive algorithms were negative. Despite negative bone scintigraphy and monoclonal protein screening, endomyocardial biopsy followed by mass spectrometry-based proteomics identified a nontransthyretin cardiac amyloidosis subtype (beyond typical ATTR/AL pathways). The report underscores that proteomics on biopsy can resolve diagnostic pitfalls when imaging and screening tests fail to classify cardiac amyloidosis.
Koppelaar AJ, Zwetsloot PP, von der Thüsen JH et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗
Multimodality Imaging Reveals Rare Hereditary Transthyretin Amyloidosis Mimicking Hypertrophic Cardiomyopathy.
This case studied a 52-year-old Moroccan woman with prior nonobstructive hypertrophic cardiomyopathy phenotype to determine whether multimodality imaging could reveal hereditary transthyretin (TTR) cardiac amyloidosis. Cardiac MRI showed asymmetric hypertrophy with papillary muscle involvement plus markedly elevated native T1 and extracellular volume, and bone scintigraphy demonstrated intense tracer uptake consistent with ATTR. The study is clinically significant because it shows how hereditary ATTR can masquerade as hypertrophic cardiomyopathy, supporting comprehensive imaging and genetic confirmation in ventricular hypertrophy phenocopies.
Panelo M, Tuya-Acosta Y, Soto-Priore A et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗
Transthyretin Cardiac Amyloidosis in a Safety-Net Hospital: A Case Series of 10 Afro-Caribbean Patients.
This case series studied 10 Afro-Caribbean patients diagnosed with transthyretin cardiac amyloidosis (ATTR-CA) in a safety-net hospital, in the context of the Val122Ile (V142Ile) variant prevalence. All patients had positive 99mTc-PYP scintigraphy, with presentations ranging from heart failure (7/10) to syncope with high-degree atrioventricular block and pericardial tamponade (3/10). The findings highlight underdiagnosis risk in Afro-Caribbean populations and support using 99mTc-PYP-based diagnostic pathways to detect ATTR-CA despite demographic disparities.
Rattan K, Allison EL, Palmer WA et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗
Donut Morphology of Cardiac Amyloidosis: A Glazed Over Diagnosis.
This case studied a 74-year-old man with heart failure with preserved ejection fraction, atrial fibrillation, and carpal tunnel syndrome who had a false-negative cardiac amyloid radionuclide imaging result performed elsewhere. Cardiac MRI revealed isolated circumferential basal wall thickening with localized subendocardial late gadolinium enhancement and extracellular volume changes, consistent with transthyretin cardiac amyloidosis in a nondiffuse (early) pattern. The report is significant because it shows that “donut”/localized amyloid distribution can produce false-negative technetium-99m pyrophosphate imaging, so MRI and clinical context should prompt further evaluation.
Aggarwal P, Alpert C, Davies D · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗
When Hematologic Response Does Not Translate to Cardiac Recovery in AL Amyloidosis.
This case studied a 66-year-old woman with AL (light-chain) cardiac amyloidosis to examine why hematologic response may not translate into cardiac recovery. Although daratumumab-based chemotherapy substantially reduced free λ light chains after plasma cell myeloma was confirmed by bone marrow biopsy, cardiac status did not recover, with CMR supporting infiltrative cardiomyopathy. The report is clinically important because it reinforces that cardiac outcomes in AL amyloidosis can lag behind hematologic response, especially in advanced disease.
Futela P, Vinod P, Pushparaji B et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗
Rare Hereditary Cardiac Amyloidosis Treated With SGLT2 Inhibitor: Beyond ATTR/AL.
This case studied a 61-year-old man with progressive heart failure and family history of amyloidosis to evaluate a rare hereditary cardiac amyloidosis beyond typical ATTR or AL. Cardiac MRI and echocardiography supported infiltrative amyloidosis, light-chain CA was excluded, and genetic testing identified an apolipoprotein (Apo) mutation consistent with apolipoprotein-related hereditary cardiac amyloidosis, after which an SGLT2 inhibitor was used. The significance is that SGLT2 inhibition may be a therapeutic option to consider in non-ATTR/non-AL hereditary cardiac amyloidosis phenotypes when evidence is otherwise limited.
Voran JC, Radić Ž, Kilian LS et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗
Hereditary Transthyretin Cardiac Amyloidosis With Severe Left Ventricular Outflow Tract Obstruction Mimicking Hypertrophic Obstructive Cardiomyopathy.
This case studied a 49-year-old man initially diagnosed with hypertrophic obstructive cardiomyopathy due to septal hypertrophy and severe LVOT obstruction. Cardiac MRI showed diffuse subendocardial late gadolinium enhancement while bone scintigraphy showed low-grade myocardial uptake, and genetic testing identified a pathogenic TTR variant causing hereditary transthyretin cardiac amyloidosis. The report is significant because it documents severe LVOT obstruction as a rare ATTR presentation, supporting genetic and amyloid-focused evaluation in HCM-like cases.
Nissan B, Magadale N, Kaplinskiy V et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗
Smartwatch-Detected Sinus Tachycardia Unmasking AL Cardiac Amyloidosis in a Young Adult.
This case studied a 36-year-old woman in whom smartwatch-detected sinus tachycardia prompted evaluation for immunoglobulin light-chain (AL) cardiac amyloidosis. Cardiac MRI raised suspicion for amyloidosis and Mayo Clinic stage III IgA lambda AL was confirmed by laboratory testing and histology. The report is clinically significant because wearable technology can accelerate recognition of AL cardiac amyloidosis in young adults with subtle or nonspecific symptoms, enabling earlier diagnosis and treatment.
O’Dea G, O’Gorman P, Giblin GT · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗
Amyloid Light Chain Amyloidosis Involving the Heart and Temporal Arteries, Mimicking Giant Cell Arteritis.
This case report studied amyloid light-chain (AL) amyloidosis in a 74-year-old man who initially presented with jaw claudication and temporal artery tenderness and was misdiagnosed as giant cell arteritis. Cardiac magnetic resonance suggested infiltrative cardiomyopathy due to amyloid, and AL amyloidosis was confirmed by temporal artery biopsy, with treatment using bortezomib, cyclophosphamide, and dexamethasone. The report highlights that AL amyloidosis can mimic giant cell arteritis and should be considered when infiltrative cardiac features emerge, enabling earlier, targeted plasma-cell–directed therapy.
Rashed A, Fernandes E, Saito R et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗
Successful Heart Transplantation in a Patient With Triple Infiltrative Cardiomyopathy: Sarcoidosis, AL and TTR Amyloidosis.
This case report evaluated a patient with triple infiltrative cardiomyopathy—cardiac sarcoidosis plus both AL and transthyretin (TTR) amyloidosis—after heart transplantation. The coexistence of sarcoidosis and AL/TTR amyloid was identified in myocardial tissue using liquid chromatography tandem mass spectrometry, supported by advanced cardiac magnetic resonance and fluorodeoxyglucose positron emission tomography. The findings are clinically significant because they demonstrate that multiple infiltrative processes can coexist in the same heart, affecting diagnostic strategy and management planning.
Nikolaidis LA, Hassan OA, Khariton Y et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗
Apolipoprotein A-IV Cardiac Amyloidosis Presenting as Massive Ventricular Wall Thickening Mimicking Hypertrophic Cardiomyopathy.
This case report studied apolipoprotein A-IV (AApoAIV) cardiac amyloidosis in a 64-year-old woman initially thought to have hypertrophic cardiomyopathy. Multimodality imaging showed severe left ventricular wall thickening with hypertrophic-cardiomyopathy–like physiology, but technetium-99m pyrophosphate scintigraphy showed no myocardial uptake and the final diagnosis was consistent with AApoAIV amyloidosis. The report is significant because it shows how AApoAIV amyloidosis can masquerade as hypertrophic cardiomyopathy and underscores the need for amyloid-specific evaluation when imaging patterns are atypical.
Coderre R, Tersalvi G, Adigun RO et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗
Unmasking AL Cardiac Amyloidosis During Familial Cardiomyopathy Screening.
This case report examined how AL cardiac amyloidosis can be uncovered during familial cardiomyopathy screening in a 65-year-old asymptomatic man. Echocardiography and cardiac magnetic resonance showed severe biventricular hypertrophy with late gadolinium enhancement despite normal extracellular volume, and bone scintigraphy showed no cardiac tracer uptake (Perugini grade 0), prompting further AL-focused diagnostic workup. The clinical significance is that AL amyloidosis may be missed in “familial hypertrophic cardiomyopathy” pathways, so multimodality imaging and appropriate amyloid testing can enable earlier diagnosis and risk stratification.
Barberis Barcia G, Toranzo-Nieto I, González-Calle V et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗
p.(V142I)-Associated Variant Transthyretin Amyloid Cardiomyopathy Complicating Complex Congenital Heart Disease: A Lethal Combination.
This case report studied p.(V142I)-associated transthyretin amyloid cardiomyopathy (ATTRv-CM) in a 51-year-old Nigerian man with complex congenital heart disease (double outlet right ventricle). The key finding was that cardiac amyloidosis was suspected on echocardiography and confirmed by cardiac magnetic resonance and bone scintigraphy, with genetic sequencing identifying homozygosity for the TTR p.(V142I) variant. The significance is that this lethal ATTRv-CM variant can complicate congenital heart disease, emphasizing the need for early amyloid evaluation in high-risk ancestry and genotype contexts.
Zathar Z, Choy CH, Al-Sakini N et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗
Exploration of Arrhythmia Burden in Cardiac Amyloidosis Using Implantable Loop Recorders: The EXCALIBUR Study.
The EXCALIBUR study prospectively characterized arrhythmic burden in 110 treatment-naïve patients with newly diagnosed transthyretin amyloid cardiomyopathy (ATTR-CM) or light-chain cardiac amyloidosis (AL-CA) using implantable loop recorders. It aimed to relate objectively measured arrhythmia burden to amyloid subtype and disease characteristics through comprehensive phenotyping including cardiac magnetic resonance (CMR). Quantifying real-world arrhythmia burden may improve risk prediction and guide monitoring and therapy decisions in cardiac amyloidosis.
Ioannou A, Patel R, Mansell J et al. · Journal of the American College of Cardiology · (2026) · 2 citations · View on PubMed ↗ · Free PDF ↗
Pulmonary vascular disease (CTEPH/CPTE) imaging & risk stratification
Evaluating the Accuracy and Efficiency of Virtual Reality Segmentation for Black-Blood Fetal Cardiac MRI.
This retrospective feasibility study evaluated a virtual reality–based volumetric segmentation pipeline (Elucis, Realize Medical) for black-blood fetal cardiac MRI to generate 3D congenital heart disease (CHD) models. The key finding was that the VR segmentation workflow could be applied to fetal cardiac MRI images to support 3D model generation for CHD assessment. The significance is that more efficient, reproducible segmentation could improve fetal CHD modeling when fetal echocardiography is limited by positioning or maternal factors.
Azar S, Friesen R, Rejeti SBY et al. · Pediatric cardiology · (2026) · View on PubMed ↗
Navigating the irradiated ureter: multi-institutional outcomes of robotic ureteral reconstruction for radiation-induced strictures.
This multi-institutional retrospective study evaluated robotic ureteral reconstruction outcomes for radiation-induced ureteral strictures using the CORRUS database (2018–2024). The key finding was the reported multi-institutional surgical outcomes for patients undergoing robotic reconstruction for strictures caused by prior pelvic radiation. The clinical significance is that robotic reconstruction may offer a feasible approach in a challenging irradiated field where scarring and impaired tissue mobility complicate conventional surgery.
Lee M, Wegner G, Santos R et al. · World journal of urology · (2026) · View on PubMed ↗
Geometric morphological parameters from cardiac magnetic resonance imaging in assessment of chronic pulmonary thromboembolism, a prospective pilot study.
This prospective pilot study evaluated whether cardiac magnetic resonance (CMR) geometric-morphological metrics—biventricular fractal dimension (FD) and perimeter-area ratio (PAR) measured on short-axis cine images—can assess and stratify chronic pulmonary thromboembolism (CPTE) in 53 CPTE patients (16 with chronic thromboembolic pulmonary disease (CTEPD) and 37 with chronic thromboembolic pulmonary hypertension (CTEPH)) and 53 matched healthy controls. The study found that CMR-derived geometric-morphological parameters differed between CPTE subgroups and controls and were associated with right-heart catheterization findings obtained within 24 hours. These CMR metrics may provide a noninvasive imaging approach to risk stratification in CPTE/CTEPH, potentially improving selection for management and follow-up.
Du J, Guo Y, Yu H et al. · European radiology experimental · (2026) · View on PubMed ↗ · Free PDF ↗
CMR late gadolinium enhancement (LGE) and arrhythmia risk
Malignant Early Repolarization Syndrome Unmasked by Acute Respiratory Distress Syndrome in a Young Adult.
This case report studied malignant early repolarization syndrome (ERS) in a previously healthy 24-year-old man whose idiopathic ventricular fibrillation was unmasked during acute respiratory distress syndrome (ARDS). The key finding was recurrent VF triggered by short-coupled premature ventricular complexes during hypoxemia and hypokalemia, with inferolateral J-point elevation on ECG and suppression with quinidine and isoproterenol. The significance is that systemic stressors like ARDS can precipitate lethal ERS arrhythmias, supporting heightened monitoring and targeted antiarrhythmic strategies during critical illness.
Sah S, Doshi P, Bhandari J et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗
Multimodality Assessment for Sudden Cardiac Death Risk Stratification in Non-Ischemic Cardiomyopathy: A Case-Based Framework Integrating Cardiac Magnetic Resonance, Electrophysiologic Observations, and Genetics.
This case-based framework article addressed sudden cardiac death (SCD) risk stratification in non-ischemic cardiomyopathy (NICM) by integrating cardiac magnetic resonance (CMR) findings—especially late gadolinium enhancement (LGE)—with electrophysiologic observations and genetics. It emphasizes that CMR alone incompletely captures arrhythmic substrate and that multimodality integration can better identify patients at risk while reducing unnecessary ICD implantation. Clinically, this approach aims to improve personalized SCD prevention strategies in NICM beyond left ventricular ejection fraction (LVEF) alone.
Litt MJ, Oraii A, Garcia FC et al. · Indian pacing and electrophysiology journal · (2026) · View on PubMed ↗ · Free PDF ↗
Chagas Cardiomyopathy: New-Onset Biventricular Failure and Refractory Ventricular Arrhythmias.
This case report described two men with Chagas disease (Trypanosoma cruzi infection) presenting with severe biventricular failure and refractory ventricular arrhythmias, including a 52-year-old from El Salvador with nonischemic late gadolinium enhancement on cardiac imaging. The key finding was that Chagas cardiomyopathy can present as acute, life-threatening biventricular dysfunction with ventricular arrhythmias requiring inotropes and a wearable cardioverter-defibrillator despite guideline-directed medical therapy. Clinically, it highlights the need to consider T. cruzi in nonischemic cardiomyopathy with late gadolinium enhancement and refractory ventricular arrhythmias, especially in patients with relevant geographic exposure.
Metri AA, Rehman OU, Kaiprath AR et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗
Myocardial late gadolinium enhancement is strongly associated with ventricular arrhythmias in mitral valve prolapse.
This study assessed whether cardiac MRI findings—specifically myocardial late gadolinium enhancement (LGE)—are associated with ventricular arrhythmias in 45 consecutive patients with mitral valve prolapse (MVP) using 24-hour Holter monitoring and exercise stress testing. Myocardial LGE burden (expressed as % of left ventricular mass and stratified into tertiles: 0%, 1–4%, and ≥5%) was strongly associated with ventricular arrhythmias, including premature ventricular beats and ventricular tachycardia. Clinically, quantifying LGE on CMR may help risk-stratify MVP patients for ventricular arrhythmias and guide closer monitoring or preventive management.
Vedernikov NL, Goitein O, Goldkorn R et al. · The international journal of cardiovascular imaging · (2026) · View on PubMed ↗ · Free PDF ↗
Fetal cardiac MRI modeling & reconstruction pipelines
Towards Faster Fetal 3D CINE Cardiac MRI Reconstruction Using Region-Optimized Virtual Coils (ROVir).
This feasibility study developed and evaluated a computationally efficient fetal 3D balanced SSFP (bSSFP) CINE cardiac MRI reconstruction pipeline in 10 volunteers using region-optimized virtual coils (ROVir) for coil compression, compared with singular value decomposition (SVD) coil compression. ROVir reduced radial streaking artifacts, increased effective temporal resolution, and improved diagnostic image quality versus the prior SVD-based approach. Faster, higher-quality fetal cardiac MRI reconstruction could improve clinical workflow and diagnostic confidence in fetal cardiology imaging.
Piek M, Töger J, Heiberg E et al. · Magnetic resonance in medicine · (2026) · View on PubMed ↗ · Free PDF ↗
Aortic valve disease physiology (AS/TAV) using imaging flow metrics
Hemodynamic Flow Signatures: A Novel Paradigm for the Evaluation of Transcatheter Aortic Valve Performance.
This article proposed a hemodynamic flow–based framework for evaluating transcatheter aortic valve (TAV) performance, contrasting limitations of echocardiography with the capabilities of 4D flow CMR. It argues that 4D flow CMR can quantify systolic flow displacement (eccentricity), systolic flow reversal ratio (conduit inefficiency), wall shear stress, and energetic efficiency to detect persistent nonphysiological flow even when transvalvular gradients improve. The approach could improve assessment of TAV success and help identify patients at risk despite apparently adequate pressure-gradient outcomes.
Maznyczka A, De Backer O, Bapat VN et al. · Circulation. Cardiovascular interventions · (2026) · View on PubMed ↗ · Free PDF ↗
Transaortic flow is associated with symptom-driven aortic valve replacement in aortic stenosis.
This prospective, multicentre observational PRIMID study examined whether transaortic flow-rate (TFR), calculated from stroke volume divided by left ventricular ejection time, is associated with symptom-driven aortic valve replacement (AVR) in asymptomatic patients with moderate-to-severe aortic stenosis (AS). In follow-up of at least one year (with symptom-driven AVR as the primary outcome), higher or abnormal TFR was linked to subsequent development of symptoms leading to AVR. The findings suggest that TFR from echocardiography/physiology-based assessment may refine timing of intervention in AS beyond conventional severity measures.
Pallikadavath S, Hogrefe K, Kelly DJ et al. · The international journal of cardiovascular imaging · (2026) · View on PubMed ↗ · Free PDF ↗
Machine learning & computational imaging for cardiac MRI
CardioSynergyNet: A Closed-Loop Multi-Task Deep Learning Architecture for Cardiac Segmentation and Biomarkers with Diagnosis from Paired ED-ES Cine-MRI.
This paper introduced CardioSynergyNet, a closed-loop multi-task deep learning architecture for paired end-diastolic (ED) and end-systolic (ES) cine-MRI that jointly performs cardiac segmentation, biomarker extraction, and diagnosis. Using a weight-shared encoder plus Cross-Phase Deformation Attention (CPDA) and a Differentiable Biomarker Extraction Layer (DBEL), the model targets eight clinical biomarkers derived from segmentation and supports diagnosis without sacrificing task accuracy. A unified model could streamline cardiac MRI analysis and improve consistency of biomarker-based diagnosis from ED–ES cine data.
Alqahtani S · Tomography (Ann Arbor, Mich.) · (2026) · View on PubMed ↗ · Free PDF ↗
Cardiac MRI biomarkers of inflammation & systemic risk
Comparison of cardiac MRI features of fibrosis and strain for early cardiac dysfunction assessment in patients with systemic lupus erythematosus and Sjögren’s syndrome.
This CMR study compared cardiac involvement in systemic lupus erythematosus (SLE) patients with and without coexisting Sjögren’s syndrome (SS) by enrolling 36 SLE+SS, 36 SLE-only, and 20 matched healthy controls. It assessed LV global strain, native T1/T2, extracellular volume fraction (ECV), and late gadolinium enhancement (LGE) to determine whether SS modifies cardiac dysfunction and remodeling. The results support CMR-based characterization of subclinical myocardial injury and may help stratify cardiac risk in SLE patients with SS.
Yang Z, Wang LL, Meng X et al. · Lupus science & medicine · (2026) · View on PubMed ↗ · Free PDF ↗
Pregnancy-associated MINOCA: Diagnostic challenges and emergency management in young women.
This narrative review focused on pregnancy-associated myocardial infarction with nonobstructive coronary arteries (MINOCA), emphasizing diagnostic challenges and emergency management in young women during pregnancy and the early postpartum period. It highlights that pregnancy-amplified conditions—such as hypertensive disorders of pregnancy (HDP), gestational diabetes mellitus (GDM), antiphospholipid syndrome (APS), inherited thrombophilia, and spontaneous coronary artery dissection—can contribute to MINOCA-like presentations, but mechanistic evidence is uneven. Clinically, the review underscores the need for heightened suspicion and tailored emergency evaluation in pregnant/postpartum patients with suspected MINOCA to rapidly identify treatable causes.
Abdu FA · The American journal of emergency medicine · (2026) · View on PubMed ↗
Mortality and recurrent events after first hospitalisation for heart failure and pulmonary heart disease: a community-based prospective study of 0.5 million Chinese adults.
This community-based prospective study followed 512,724 Chinese adults in the Kadoorie Biobank to compare prognosis after first hospitalization for heart failure (HF) versus pulmonary heart disease (PHD), using linked hospital and death registry data. HF and PHD showed different 28-day case-fatality ratios and 5-year cumulative mortality and recurrent hospitalization patterns after first admission. The results are significant for identifying prognostic disparities between HF and PHD in low- and middle-income settings and for informing risk stratification and follow-up intensity.
Ndip Agbor V, Chen Y, Wright N et al. · BMJ public health · (2026) · View on PubMed ↗
FDG-PET/CT-based treatment response predicts recurrence and overall survival in locally advanced cervical cancer.
This retrospective study analyzed 133 patients with locally advanced cervical cancer to determine whether FDG-PET/CT treatment response metrics predict recurrence and overall survival, comparing standard SUVmax with volume-based parameters metabolic tumor volume (MTV) and total lesion glycolysis (TLG). The key finding was that PET-CT response assessed using these parameters could stratify patients by risk of recurrence and overall survival, with volume-based measures providing additional predictive value beyond SUVmax. This is clinically important because it supports using quantitative FDG-PET/CT response biomarkers to guide prognosis and potentially tailor post-treatment management in locally advanced cervical cancer.
Markus M, Sartor H, Bjurberg M et al. · BMC medical imaging · (2026) · View on PubMed ↗ · Free PDF ↗
CMR and FDG PET/CT Imaging Phenotypes and their Association with Outcomes in Patients with Known or Suspected Myocarditis.
This registry-based study examined 1,646 patients who underwent FDG PET/CT for known or suspected myocarditis to test whether FDG PET/CT adds prognostic value beyond cardiac MRI (CMR) and to define imaging phenotypes. The key finding was that specific CMR–FDG PET/CT imaging phenotypes were associated with outcomes, indicating that metabolic activity on FDG PET/CT can refine risk prediction when interpreted alongside CMR findings. Scientifically, it supports an integrated CMR-plus-FDG PET/CT approach for prognostication in inflammatory cardiomyopathy.
Rojulpote CS, Hankinson SJ, Carre S et al. · Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · (2026) · View on PubMed ↗ · Free PDF ↗
Association of F11 Gene Variants With Cardiovascular Events and Cardiac Function.
This prospective study used UK Biobank data (n=408,642; European ancestry) to test whether genetic scores representing F11 (factor XI) inhibition are associated with cardiovascular events and cardiac function. The key finding was that genetically proxied FXI inhibition (via F11-based scores) was associated with increased risk of heart failure and atrial fibrillation and with measurable differences in cardiac function. This is significant because it links FXI-targeted antithrombotic strategies to potential downstream cardiac risk, informing safer therapeutic development and patient selection.
Ye Q, Hu S, Yang R et al. · Journal of the American Heart Association · (2026) · View on PubMed ↗ · Free PDF ↗
Gene-environment interactions shape cytokine-mediated inflammation and cardiovascular risk.
This study evaluated how cytokine-mediated inflammation and gene–environment interactions influence cardiovascular risk and cardiac phenotypes in 488,079 UK Biobank participants using nuclear magnetic resonance (NMR) metabolomics/proteomics, cardiac magnetic resonance (CMR), and longitudinal outcomes. Glycoprotein acetyls (GlycA) quantified chronic inflammation and, together with genetic and environmental factors, shaped cytokine-mediated inflammatory signaling linked to adverse cardiac remodeling and cardiovascular risk (as assessed by machine-learning analyses). These findings support GlycA as a mechanistic biomarker connecting systemic inflammation to CMR-defined cardiac phenotypes and highlight the importance of integrating genetic and environmental context for cardiovascular risk prediction.
Corianò M, Tahasildar S, Huang L et al. · European journal of preventive cardiology · (2026) · View on PubMed ↗ · Free PDF ↗
Generated automatically on September 25, 2026. Covers PubMed articles published September 18, 2026 – September 25, 2026. Summaries are AI-generated; always consult the original publication for clinical or research decisions.