What's New in Cardiac MRI? — September 26, 2026
AI-summarised digest of 60 PubMed articles on Cardiac MRI published in the last 7 days.
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What’s New in Cardiac MRI?
September 26, 2026 · 60 articles · 15 research themes · covering September 19, 2026 – September 26, 2026
Overview
This week’s digest is dominated by advances in cardiac magnetic resonance (CMR) as a quantitative “biomechanics and tissue characterization” platform. Multiple studies connect CMR-derived measures—such as vascular stiffness/distensibility for abdominal aortic aneurysm risk, hemodynamic forces after STEMI for predicting adverse remodeling, and deformation/strain or fibrosis markers for hypertrophic cardiomyopathy risk—to more precise, earlier risk stratification than conventional clinical variables alone. Complementing this, methodological work (e.g., faster or more motion-robust T1 mapping approaches and dose-sparing contrast strategies) aims to make quantitative CMR more feasible and reliable in real-world patients.
A second major theme is diagnostic refinement in complex cardiomyopathies, especially infiltrative disease. Case-based reports repeatedly show how amyloid phenocopies (including rare amyloid types) can mimic other cardiomyopathies such as HCM, and how “negative” standard tests (e.g., radionuclide uptake) may not fully exclude early or atypical disease—highlighting the value of CMR pattern recognition and, when needed, proteomic/genetic confirmation. In parallel, reviews and frameworks emphasize mechanism-guided evaluation for heterogeneous syndromes like MINOCA/ANOCA and immune checkpoint inhibitor cardiotoxicity, translating imaging and physiology into actionable emergency and longitudinal management.
Finally, the set includes a growing push toward automation and richer data extraction from imaging. AI-driven segmentation/biomarker pipelines and CMR radiomics synthesize information beyond visual interpretation, while novel quantitative constructs (e.g., strain-rate tensor fields, 4D-flow “flow signatures,” and geometric metrics for pulmonary thromboembolism severity) suggest that future clinical workflows may increasingly rely on multidimensional imaging features to predict outcomes and guide interventions.
CMR Quantitative Mapping & Acquisition Optimization (T1/Contrast/Techniques)
Endomyocardial fibrosis in adults: multimodality imaging phenotype and independent predictors of mortality.
This retrospective single-center cohort studied adults (≥18 years) with endomyocardial fibrosis (EMF) diagnosed between 1997 and 2024, using multimodality imaging with transthoracic echocardiography and cardiac magnetic resonance (CMR) when available. The study identified specific imaging/clinical features and independent predictors of all-cause mortality during longitudinal follow-up. These findings improve risk stratification and prognostic counseling in EMF, a rare restrictive cardiomyopathy with apical obliteration and endocardial fibrosis.
Hotta VT, Romero CE, Madrini V et al. · International journal of cardiology · (2026) · View on PubMed ↗ · Free PDF ↗
Impaired myocardial oxygen metabolism and energy efficiency in patients with dilated cardiomyopathy.
This study used non-contrast cardiovascular magnetic resonance (CMR) to assess myocardial oxygen metabolism, cardiac work, and mechano-energetic efficiency in 49 patients with dilated cardiomyopathy (DCM) versus 23 matched controls, alongside cine CMR for LVEF and LV global longitudinal strain (LVGLS), pre/post-contrast T1 mapping for extracellular volume (ECV), and first-pass perfusion. The key finding was that DCM patients showed impaired myocardial oxygen metabolism and reduced energy efficiency compared with controls. Clinically, this supports CMR-derived metabolic/energetic metrics as potential biomarkers for DCM pathophysiology and outcome risk.
Dai L, Qiao J, Wang K et al. · Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · (2026) · View on PubMed ↗ · Free PDF ↗
Intravascular imaging in myocardial infarction and ischemia with nonobstructive coronary arteries.
This review article examined how intravascular imaging—optical coherence tomography (OCT) and intravascular ultrasound (IVUS)—can characterize mechanisms in myocardial infarction with nonobstructive coronary arteries (MINOCA) and angina/ischemia with nonobstructive coronary arteries (ANOCA/INOCA) beyond coronary angiography. It found that targeted intracoronary imaging during the index angiogram is most useful in MINOCA to identify acute epicardial mechanisms, while OCT and IVUS have complementary strengths for thrombus/plaque disruption versus plaque burden/remodeling/intramural hematoma and myocardial bridging. Scientifically and clinically, the work supports mechanism-guided diagnosis and more tailored management strategies for these heterogeneous syndromes.
Nishi T, Kume T, Irimpen A et al. · Cardiovascular intervention and therapeutics · (2026) · View on PubMed ↗ · Free PDF ↗
Myocarditis-Like Presentation Leads to DSP Arrhythmogenic Cardiomyopathy Diagnosis: From Variant of Uncertain Significance to Diagnosis.
This JACC Case Reports report described a 38-year-old woman with myocarditis-like presentation (chest pain, elevated troponin, normal coronaries) whose cardiac MRI showed multifocal nonischemic late gadolinium enhancement and who had genetic testing revealing a desmoplakin (DSP) variant of uncertain significance (VUS). Follow-up CMR demonstrated persistent late gadolinium enhancement and the DSP VUS was reclassified as likely pathogenic, establishing DSP arrhythmogenic cardiomyopathy. The case highlights the clinical importance of variant reclassification over time and the role of CMR in confirming genotype-driven cardiomyopathy diagnoses.
DeLorenzo O, Farkouh F, Alameh I et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗
Gadopiclenol for Cardiac MRI: Comparison of Myocardial T1 Relaxation Times and Subjective Image Quality at Different Doses in Patients With Anderson-Fabry Disease.
This observational feasibility study evaluated gadopiclenol, a second-generation gadolinium-based contrast agent, in 3T cardiac MRI for Anderson-Fabry disease (AFD), comparing two gadopiclenol doses for myocardial T1 shortening and late gadolinium enhancement (LGE) image quality. The key finding was that gadopiclenol at different doses produced comparable LGE image quality while leveraging its high relaxivity to achieve effective myocardial contrast with reduced gadolinium exposure. This supports gadopiclenol as a potentially dose-sparing alternative for CMR in AFD.
Kollmann AT, Huflage H, Dazeh RS et al. · Investigative radiology · (2026) · View on PubMed ↗
Complete Atrioventricular Block in an HLA-B27-Positive Woman Without Overt Spondyloarthritis.
This case report described a 43-year-old HLA-B27-positive woman without overt spondyloarthritis who developed complete atrioventricular block (CAVB) requiring dual-chamber pacemaker implantation. Despite the absence of clinical spondyloarthritis, multimodal evaluation including cardiac MRI, fluorodeoxyglucose positron emission tomography, and comprehensive genetic testing supported an inflammatory/conduction-disease context associated with HLA-B27. The report emphasizes that HLA-B27-associated conduction disease can present as isolated CAVB even without overt spondyloarthritis.
Batista Lage JG, Tavares Pinheiro MV, Ferreira de Souza O et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗
Complex bilateral coronary artery fistulas with multiple drainage sites: a multimodality imaging case report.
This European Heart Journal Case Reports article described a 68-year-old patient with exertional dyspnea and dizziness found to have complex bilateral coronary artery fistulas (CAFs) with multiple drainage sites. Multimodality imaging showed CAFs originating from both coronary arteries with drainage into the superior vena cava, right atrium, and descending aorta, and functional assessment supported clinically relevant flow effects. The case illustrates how combined angiography and CT/cardiac imaging can map complex CAF anatomy to guide management decisions.
Ružičić D, Čanković M, Komazec N et al. · European heart journal. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗
Strain Rate Angle Distribution as an Indicator of Post-Infarct Myocardial Remodeling: Proof-of-Concept of a Novel Application of the MRI Derived Strain Rate Tensor Field.
This proof-of-concept study developed and applied a novel MRI-derived strain rate tensor field approach to assess post-infarct left ventricular (LV) remodeling in a rat model of myocardial infarction (MI). The key finding was that strain rate angle distribution from velocity-encoded MRI (tissue phase mapping/TPM-based processing) provided an in vivo indicator of multidirectional myocardial deformation during remodeling. This supports a new quantitative MRI framework that may improve sensitivity to early post-infarct structural changes beyond conventional strain metrics.
Totland L, Bendiksen BA, Nordén ES et al. · Magnetic resonance in medicine · (2026) · View on PubMed ↗ · Free PDF ↗
Septal Nonischemic Late Gadolinium Enhancement After Myocardial Infarction Is Associated With Adverse Remodeling and Improves Risk Stratification for Heart Failure Outcomes.
This retrospective CMR cohort study analyzed 948 patients with prior myocardial infarction, excluding those with coexisting nonischemic cardiomyopathies or myocarditis, to evaluate prognostic significance of nonischemic late gadolinium enhancement (NI-LGE) patterns. NI-LGE—defined as midwall or subepicardial enhancement—was associated with adverse LV remodeling and improved risk stratification for heart failure outcomes using competing risk analysis. Clinically, septal NI-LGE after MI emerges as a practical CMR marker to identify patients at higher risk for subsequent heart failure.
Zhou P, Zhao K, Aisikaier K et al. · Journal of the American Heart Association · (2026) · View on PubMed ↗ · Free PDF ↗
Native myocardial T1 mapping using rapid 1.5T T1FLASH and T1 MOLLI during breath-hold and free-breathing.
This prospective study evaluated native myocardial T1 mapping at 1.5T in 14 healthy volunteers comparing rapid T1FLASH and modified Look-Locker inversion recovery with motion correction (T1 MOLLI MOCO) acquired during breath-hold versus free-breathing. The key finding is that rapid T1FLASH enables shorter breath-hold T1 mapping, addressing motion/artifact limitations of conventional breath-hold T1 mapping, while performance was assessed against T1 MOLLI MOCO. This is clinically significant because it may improve feasibility and image quality of quantitative CMR T1 mapping in patients who cannot reliably perform breath-holds.
Röwer LM, Hussen-Demir Y, Verde PE et al. · BMC cardiovascular disorders · (2026) · View on PubMed ↗ · Free PDF ↗
Obstructive Intramural Coronary Amyloidosis: Uncommon or Under-Recognized Cause of Microvascular Angina?
This JACC Case Reports study investigated an 83-year-old man with obstructive intramural coronary amyloidosis (OICA) presenting as microvascular angina with persistently elevated troponin despite normal coronary angiography and nondiagnostic CMR. The key finding was that endomyocardial biopsy demonstrated extensive transthyretin amyloid deposition predominantly within intramural coronary arterioles, establishing OICA as the cause. The clinical significance is that it highlights an under-recognized diagnostic pathway for cardiac amyloidosis when patients have ischemic symptoms and troponin elevation but no obstructive coronary disease.
Fazzini L, D’Elia E, Sciatti E et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗
Epicardial Amyloidoma Mimicking Secondary Cardiac Lymphoma: A Sneeze Away From the Diagnosis.
This case report studied a man with indolent B-cell lymphoma and monoclonal gammopathy who developed an epicardial mass mimicking malignant cardiac infiltration. The key finding was that despite CMR and PET/bone scintigraphy being suspicious for secondary cardiac lymphoma or Erdheim-Chester disease, surgical biopsy revealed localized amyloid deposition (amyloidoma) confirmed by Congo red staining. This is significant because it warns that localized cardiac amyloid can closely mimic lymphoma on multimodality imaging, potentially preventing misdiagnosis and inappropriate therapy.
Vella A, Disabato G, Roncoroni L et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗
Apolipoprotein A-IV Cardiac Amyloidosis as a Diagnostic Pitfall: Beyond the Noninvasive Algorithm.
This case report studied a 71-year-old man with reduced kidney function and new-onset heart failure with concentric LV hypertrophy and an apical-sparing strain pattern, where standard noninvasive cardiac amyloidosis algorithms were negative. The key finding was that CMR suggested an infiltrative phenotype, but only mass spectrometry–based proteomics after biopsy clarified the diagnosis as apolipoprotein A-IV cardiac amyloidosis. The clinical significance is that it demonstrates a diagnostic pitfall: rare amyloid types may require proteomic confirmation even when conventional noninvasive testing is unrevealing.
Koppelaar AJ, Zwetsloot PP, von der Thüsen JH et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗
Multimodality Imaging Reveals Rare Hereditary Transthyretin Amyloidosis Mimicking Hypertrophic Cardiomyopathy.
This case report studied a 52-year-old Moroccan woman previously diagnosed with nonobstructive hypertrophic cardiomyopathy who had recurrent pericardial chest pain and ventricular hypertrophy. The key finding was that multimodality imaging (including CMR with elevated native T1 and extracellular volume and bone scintigraphy with intense tracer uptake) revealed hereditary transthyretin cardiac amyloidosis mimicking HCM. This is significant because it emphasizes the need to reconsider HCM diagnoses in atypical presentations and to use imaging to uncover amyloid phenocopies.
Panelo M, Tuya-Acosta Y, Soto-Priore A et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗
Transthyretin Cardiac Amyloidosis in a Safety-Net Hospital: A Case Series of 10 Afro-Caribbean Patients.
This case series studied 10 Afro-Caribbean patients diagnosed with transthyretin cardiac amyloidosis (ATTR-CA) in a safety-net hospital, with clinical presentation ranging from heart failure to syncope with high-degree atrioventricular block and pericardial tamponade. The key finding was that all 10 patients had positive 99mTc-PYP scans, and CMR supported the diagnosis, underscoring underdiagnosis despite known prevalence of the Val122Ile (V142Ile) variant in Black populations. The clinical significance is that it supports systematic screening and improved diagnostic pathways for ATTR-CA in Afro-Caribbean communities at higher genetic risk.
Rattan K, Allison EL, Palmer WA et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗
Donut Morphology of Cardiac Amyloidosis: A Glazed Over Diagnosis.
This case studied diagnostic pitfalls in a 74-year-old man with suspected transthyretin cardiac amyloidosis (ATTR-CM) after false-negative technetium-99m pyrophosphate scintigraphy (cardiac amyloid radionuclide imaging, CARI). Cardiac magnetic resonance showed an atypical “donut” pattern with isolated circumferential basal wall thickening and localized subendocardial late gadolinium enhancement, consistent with early/nondiffuse amyloid infiltration despite negative radionuclide imaging. The report highlights that early-stage ATTR-CM can evade standard CARI and that CMR pattern recognition can be crucial for timely diagnosis and management.
Aggarwal P, Alpert C, Davies D · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗
When Hematologic Response Does Not Translate to Cardiac Recovery in AL Amyloidosis.
This case studied the discordance between hematologic response and cardiac recovery in a 66-year-old woman with immunoglobulin light-chain (AL) amyloidosis due to plasma cell myeloma. Despite daratumumab-based chemotherapy substantially reducing free λ light chains, the patient’s cardiac status did not recover, with low QRS voltage and severe concentric thickening with apical sparing on strain imaging and supportive cardiac magnetic resonance findings. Clinically, it emphasizes that hematologic response in AL amyloidosis does not reliably predict cardiac improvement, particularly in advanced disease.
Futela P, Vinod P, Pushparaji B et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗
Rare Hereditary Cardiac Amyloidosis Treated With SGLT2 Inhibitor: Beyond ATTR/AL.
This case studied a rare hereditary cardiac amyloidosis patient (61-year-old man) in whom light-chain and transthyretin etiologies were excluded and an SGLT2 inhibitor was used. Genetic testing identified an Apolipoprotein gene mutation (Apolipoprotein-related hereditary amyloidosis; truncated in abstract), and the patient’s progressive heart failure (NYHA III) with cardiac magnetic resonance late gadolinium enhancement and echocardiographic diastolic dysfunction was treated beyond typical ATTR/AL paradigms using an SGLT2 inhibitor. The significance is that SGLT2 inhibition may be considered for selected non-ATTR/non-AL hereditary amyloid cardiomyopathy phenotypes when evidence is otherwise limited.
Voran JC, Radić Ž, Kilian LS et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗
Hereditary Transthyretin Cardiac Amyloidosis With Severe Left Ventricular Outflow Tract Obstruction Mimicking Hypertrophic Obstructive Cardiomyopathy.
This case studied hereditary transthyretin (TTR) cardiac amyloidosis in a 49-year-old man whose presentation mimicked hypertrophic obstructive cardiomyopathy (HOCM) with severe left ventricular outflow tract (LVOT) obstruction. Cardiac magnetic resonance showed diffuse subendocardial late gadolinium enhancement while bone scintigraphy showed low-grade myocardial uptake, and genetic testing identified a pathogenic TTR variant (truncated in abstract). The report is significant because it shows that TTR amyloidosis can produce marked LVOT obstruction and be misdiagnosed as HOCM, warranting amyloid-focused evaluation when imaging features are atypical.
Nissan B, Magadale N, Kaplinskiy V et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗
Smartwatch-Detected Sinus Tachycardia Unmasking AL Cardiac Amyloidosis in a Young Adult.
This case studied how smartwatch-detected sinus tachycardia can unmask immunoglobulin light-chain (AL) cardiac amyloidosis in a 36-year-old woman. After frequent high heart-rate alerts, cardiac magnetic resonance raised suspicion for amyloidosis and Mayo Clinic stage III IgA λ AL cardiac amyloidosis was confirmed by laboratory and histological testing. The clinical significance is that wearable technology may accelerate recognition of cardiac amyloidosis in younger patients with nonspecific symptoms, enabling earlier treatment.
O’Dea G, O’Gorman P, Giblin GT · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗
Amyloid Light Chain Amyloidosis Involving the Heart and Temporal Arteries, Mimicking Giant Cell Arteritis.
This case studied amyloid light-chain (AL) amyloidosis involving both the heart and temporal arteries in a 74-year-old man initially treated as giant cell arteritis. Temporal artery biopsy confirmed AL amyloidosis, and cardiac evaluation showed infiltrative cardiomyopathy with cardiac magnetic resonance suggesting amyloid. The significance is that temporal artery involvement can mimic giant cell arteritis, and recognizing this overlap can lead to prompt AL-directed therapy (bortezomib, cyclophosphamide, dexamethasone).
Rashed A, Fernandes E, Saito R et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗
Successful Heart Transplantation in a Patient With Triple Infiltrative Cardiomyopathy: Sarcoidosis, AL and TTR Amyloidosis.
This case studied a rare “triple infiltrative cardiomyopathy” scenario in which cardiac sarcoidosis coexisted with both AL and transthyretin (TTR) amyloidosis in a patient undergoing heart transplantation. The coexistence was identified in myocardial tissue using liquid chromatography tandem mass spectrometry, supported by advanced cardiac magnetic resonance and FDG-PET imaging. Scientifically and clinically, it underscores the value of tissue-based proteomic confirmation and multimodality imaging when multiple infiltrative processes may coexist.
Nikolaidis LA, Hassan OA, Khariton Y et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗
Apolipoprotein A-IV Cardiac Amyloidosis Presenting as Massive Ventricular Wall Thickening Mimicking Hypertrophic Cardiomyopathy.
This case studied apolipoprotein A-IV (AApoAIV) cardiac amyloidosis in a 64-year-old woman presenting with massive ventricular wall thickening that mimicked hypertrophic cardiomyopathy. Multimodality imaging suggested infiltrative cardiomyopathy with diffuse late gadolinium enhancement, abnormal nulling, elevated T1, and apical-sparing strain, while technetium-99m pyrophosphate scintigraphy showed no myocardial uptake (supporting non-ATTR physiology). The significance is that AApoAIV amyloidosis can present like HCM but may require alternative diagnostic pathways beyond ATTR-focused radionuclide imaging.
Coderre R, Tersalvi G, Adigun RO et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗
Unmasking AL Cardiac Amyloidosis During Familial Cardiomyopathy Screening.
This case studied how AL cardiac amyloidosis can be unmasked during familial cardiomyopathy screening in a 65-year-old asymptomatic man. Although bone scintigraphy showed no pathologic tracer uptake (Perugini grade 0) and the initial referral was for hypertrophic cardiomyopathy screening, echocardiography and cardiac magnetic resonance revealed severe biventricular hypertrophy with normal extracellular volume and late gadolinium enhancement in the septum and atria, raising suspicion for infiltrative cardiomyopathy. The clinical significance is that family screening for hypertrophic cardiomyopathy can incidentally detect AL amyloidosis, and negative ATTR radionuclide imaging does not exclude AL disease.
Barberis Barcia G, Toranzo-Nieto I, González-Calle V et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗
Evaluating the Accuracy and Efficiency of Virtual Reality Segmentation for Black-Blood Fetal Cardiac MRI.
This retrospective feasibility study evaluated a novel volumetric virtual-reality–assisted segmentation pipeline (Elucis, Realize Medical) for black-blood contrast fetal cardiac MRI to generate 3D congenital heart disease (CHD) models in pregnant women undergoing fetal cardiac MRI screening. The approach enabled accurate and efficient 3D segmentation of fetal cardiac structures from high-resolution T2-weighted single-shot black-blood MRI, supporting reliable model generation for CHD assessment. If validated in larger cohorts, VR-guided segmentation could streamline fetal cardiac MRI workflows and improve access to complementary CHD imaging when fetal position or maternal factors limit echocardiography.
Azar S, Friesen R, Rejeti SBY et al. · Pediatric cardiology · (2026) · View on PubMed ↗
Navigating the irradiated ureter: multi-institutional outcomes of robotic ureteral reconstruction for radiation-induced strictures.
This multi-institutional retrospective CORRUS database study assessed outcomes of robotic ureteral reconstruction in patients with radiation-induced ureteral strictures treated between 2018 and 2024. The key finding was that robotic reconstruction is feasible and provides acceptable surgical outcomes despite the challenges of dense peri-ureteral scarring and impaired tissue mobility in irradiated fields. Clinically, this supports robotic surgery as a practical option for restoring ureteral continuity in patients with complex post-radiation strictures where conventional reconstruction may be difficult.
Lee M, Wegner G, Santos R et al. · World journal of urology · (2026) · View on PubMed ↗
Malignant Early Repolarization Syndrome Unmasked by Acute Respiratory Distress Syndrome in a Young Adult.
This JACC Case Reports report describes a previously healthy 24-year-old man with early repolarization syndrome (ERS) unmasked during acute respiratory distress syndrome (ARDS) after out-of-hospital ventricular fibrillation (VF) arrest. The patient developed recurrent VF triggered by short-coupled premature ventricular complexes during hypoxemia and hypokalemia, with inferolateral J-point elevation (>0.2 mV) on ECG and suppression of arrhythmias with quinidine and isoproterenol. The case highlights how systemic stressors such as hypoxemia and electrolyte derangements can precipitate malignant ERS arrhythmias, informing acute risk recognition and targeted antiarrhythmic management.
Sah S, Doshi P, Bhandari J et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗
Phenotypic Transition From Danon Disease to Arrhythmogenic Cardiomyopathy: Multimodality and Histopathologic Evidence.
This JACC Case Reports article documents a 30-year-old woman with a phenotypic transition from genetically confirmed Danon disease due to LAMP2 pathogenic variants to arrhythmogenic cardiomyopathy features. Over time, she progressed from a hypertrophic phenotype with short PR interval to diffuse low QRS voltages, recurrent ventricular arrhythmias, and cardiac MRI findings of extensive ring-like late gadolinium enhancement with biventricular systolic dysfunction. Scientifically and clinically, it suggests that Danon disease can evolve into an arrhythmogenic cardiomyopathy-like substrate, supporting multimodality surveillance and consideration of arrhythmia-focused management.
Quintella Sangiorgi Olivetti N, Belitardo GP, Cerqueira Matheus F et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗
p.(V142I)-Associated Variant Transthyretin Amyloid Cardiomyopathy Complicating Complex Congenital Heart Disease: A Lethal Combination.
This JACC Case Reports report describes a 51-year-old Nigerian man with complex congenital heart disease (double outlet right ventricle) who developed transthyretin amyloid cardiomyopathy due to homozygosity for the p.(V142I) TTR variant. Cardiac amyloidosis was suspected on echocardiography and confirmed with cardiac MRI and bone scintigraphy, with genetic sequencing identifying the lethal ATTRv-CM genotype. The case emphasizes that in patients with complex congenital heart disease, ATTRv-CM—particularly p.(V142I) in individuals of African ancestry—can be rapidly progressive and should be actively evaluated when imaging suggests infiltrative cardiomyopathy.
Zathar Z, Choy CH, Al-Sakini N et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗
Towards Faster Fetal 3D CINE Cardiac MRI Reconstruction Using Region-Optimized Virtual Coils (ROVir).
This feasibility study in 10 volunteers developed and tested the region-optimized virtual coils (ROVir) technique to accelerate 3D balanced steady-state free precession (bSSFP) cine fetal cardiac MRI reconstruction. Compared with singular value decomposition (SVD) coil compression, ROVir reduced radial streaking artifacts, increased effective temporal resolution, and improved diagnostic image quality. If generalizable, ROVir could enable faster, higher-quality fetal 3D cine MRI reconstruction, reducing motion sensitivity and improving clinical usability.
Piek M, Töger J, Heiberg E et al. · Magnetic resonance in medicine · (2026) · View on PubMed ↗ · Free PDF ↗
Navigating coronary microvascular dysfunction: an echocardiographic triage algorithm for cardiac magnetic resonance and coronary computed tomography angiography.
This article proposes an echocardiography-guided triage algorithm to noninvasively detect and risk-stratify suspected coronary microvascular dysfunction (CMD) and to select patients for confirmatory cardiac magnetic resonance (CMR) and coronary computed tomography angiography (CCTA). The algorithm uses frontline transthoracic echocardiography with global longitudinal strain (GLS) and a Doppler-derived coronary sinus flow (CSF) index, referring patients with abnormal initial findings for advanced imaging and quantitative phase-based assessment. If validated, this could reduce reliance on invasive coronary physiology by improving early CMD detection and optimizing downstream use of CMR/CCTA.
Güleşir ME · Journal of ultrasound · (2026) · View on PubMed ↗
CT-derived myocardial extracellular volume: current evidence, clinical utility, and the emerging role of photon-counting CT-a systematic review.
This PRISMA-compliant systematic review evaluated current evidence and clinical utility for CT-derived myocardial extracellular volume (ECV), including the emerging role of photon-counting CT, using cardiac magnetic resonance ECV as the reference standard. The review synthesized studies up to December 2025 and assessed how CT techniques can quantify diffuse myocardial interstitial expansion/fibrosis and where they may fit into routine cardiac CT workflows. Clinically, it supports the growing potential of CT-derived ECV as a more widely available alternative to CMR for diffuse fibrosis assessment, while clarifying remaining technical and validation gaps.
D’Argenzio J, Stucchi F, Tambè V et al. · European radiology experimental · (2026) · View on PubMed ↗ · Free PDF ↗
Hemodynamic Flow Signatures: A Novel Paradigm for the Evaluation of Transcatheter Aortic Valve Performance.
This study evaluated whether 4-dimensional flow cardiac magnetic resonance (4D-flow CMR) can characterize hemodynamic flow “signatures” of transcatheter aortic valve (TAV) performance in patients undergoing TAV replacement. It found that persistent nonphysiological post-TAV flow—quantified via systolic flow displacement (eccentricity), systolic flow reversal ratio (conduit inefficiency), wall shear stress, and energetic efficiency—can remain even when transvalvular gradients improve. These flow-based metrics may improve scientific and clinical assessment of TAV success beyond echocardiography by detecting residual abnormal flow that could relate to downstream outcomes.
Maznyczka A, De Backer O, Bapat VN et al. · Circulation. Cardiovascular interventions · (2026) · View on PubMed ↗ · Free PDF ↗
Abdominal Aortic Aneurysm & Vascular Stiffness (CMR/Ultrasound)
Herpes simplex virus and kallikrein-related peptidases - a functional connection in Alzheimer’s disease.
This study analyzed cerebrospinal fluid (CSF) kallikrein-related peptidase 6 (KLK6) and Alzheimer’s disease (AD) biomarkers in patients with AD and related them to markers of intrathecal anti–herpes simplex virus (HSV) immune response, using HSV-1 serostatus and the CSF-to-serum antibody index (HSV-AI), with HSV-1 infection experiments in cell culture. The key finding was an association between CSF KLK6 and AD biomarkers that also linked KLK6 to intrathecal anti-HSV immune activity, with HSV-1 infection altering KLK6 expression in vitro. Scientifically, it provides a functional connection between HSV-related immune responses and KLK6 biology that may help explain interactions between infection and AD pathology.
Goldhardt O, Robles CM, Eberl M et al. · Alzheimer’s research & therapy · (2026) · View on PubMed ↗ · Free PDF ↗
Exploration of Arrhythmia Burden in Cardiac Amyloidosis Using Implantable Loop Recorders: The EXCALIBUR Study.
The EXCALIBUR study prospectively characterized arrhythmia burden in 110 treatment-naïve patients with cardiac amyloidosis using implantable loop recorders, comparing transthyretin (ATTR-CM) versus light-chain (AL-CA) disease. It reported that continuous rhythm monitoring enabled detailed quantification of arrhythmic burden and its associations with amyloid subtype and clinical phenotype. This approach is clinically significant because it can clarify the true arrhythmia burden in cardiac amyloidosis and potentially guide risk stratification and management.
Ioannou A, Patel R, Mansell J et al. · Journal of the American College of Cardiology · (2026) · 2 citations · View on PubMed ↗ · Free PDF ↗
CardioSynergyNet: A Closed-Loop Multi-Task Deep Learning Architecture for Cardiac Segmentation and Biomarkers with Diagnosis from Paired ED-ES Cine-MRI.
CardioSynergyNet was developed and evaluated as a closed-loop, multi-task deep learning model for paired end-diastolic (ED) and end-systolic (ES) cine cardiac MRI, targeting segmentation, biomarker extraction, and diagnosis in a single jointly trained architecture. The key finding was that a weight-shared encoder with cross-phase deformation attention and a differentiable biomarker extraction layer can perform segmentation and derive multiple clinical biomarkers without sacrificing accuracy across tasks. This is significant because it streamlines cardiac MRI analysis by linking segmentation-derived biomarkers directly to diagnostic prediction in one model.
Alqahtani S · Tomography (Ann Arbor, Mich.) · (2026) · View on PubMed ↗ · Free PDF ↗
Multidisciplinary single stage surgical management of advanced breast carcinoma with concomitant left atrial myxoma.
This case report studied the multidisciplinary single-stage surgical management of a 58-year-old woman with locally advanced invasive mucinous breast carcinoma who had an incidentally discovered left atrial myxoma. The key finding was that multimodality imaging (echocardiography, cardiac MRI, and FDG PET-CT) suggested a cardiac neoplasm but could not exclude metastasis, prompting surgical management given embolic risk. Clinically, it highlights the diagnostic and therapeutic importance of considering primary cardiac tumors such as myxoma in cancer patients with intracardiac masses.
Haval S, Garg A, Pawar R et al. · Interdisciplinary cardiovascular and thoracic surgery · (2026) · View on PubMed ↗ · Free PDF ↗
Comparison of cardiac MRI features of fibrosis and strain for early cardiac dysfunction assessment in patients with systemic lupus erythematosus and Sjögren’s syndrome.
This study compared cardiac MRI markers of fibrosis and myocardial strain among 36 SLE patients with coexisting Sjögren’s syndrome (SS), 36 SLE patients without SS, and 20 matched healthy controls. It found that coexisting SS in SLE was associated with differences in cardiac function and left ventricular remodeling on CMR, using measures including native T1, T2, extracellular volume fraction (ECV), and late gadolinium enhancement (LGE) alongside global strain. The significance is that it refines understanding of how SS modifies early cardiac involvement in SLE and supports CMR-based risk assessment.
Yang Z, Wang LL, Meng X et al. · Lupus science & medicine · (2026) · View on PubMed ↗ · Free PDF ↗
Geometric morphological parameters from cardiac magnetic resonance imaging in assessment of chronic pulmonary thromboembolism, a prospective pilot study.
This prospective pilot study assessed whether geometric morphological parameters derived from cardiac MRI can stratify chronic pulmonary thromboembolism (CPTE) severity in 53 CPTE patients (CTEPD vs CTEPH) and 53 matched healthy controls. It found that biventricular fractal dimension (FD) and perimeter-area ratio (PAR), quantified on short-axis cine images at end-diastole and end-systole across basal/mid/apical levels, differed by disease group and were evaluated alongside right heart catheterization performed within 24 hours. Scientifically and clinically, these CMR-derived geometric metrics may provide additional tools for CPTE assessment and risk stratification beyond conventional measures.
Du J, Guo Y, Yu H et al. · European radiology experimental · (2026) · View on PubMed ↗ · Free PDF ↗
Macroalbuminuria as a marker of cardiac damage in patients with type 2 diabetes: insights from multimodality cardiac imaging and biomarkers.
This cross-sectional study evaluated whether macroalbuminuria is a marker of cardiac damage in 49 adults with type 2 diabetes (T2D) and stage 3 chronic kidney disease (CKD), compared with 20 controls, using multimodality cardiac imaging and serum biomarkers. It found that macroalbuminuria was associated with worse cardiac structure/function on cardiac MRI and echocardiography and with higher levels of myocardial stress/fibrosis-related biomarkers including sST2 (and other matrix-related markers). The significance is that macroalbuminuria may serve as an accessible indicator of subclinical cardiac injury in T2D with CKD.
Olloquiegui XI, Andueza SE, Izco MP et al. · Journal of physiology and biochemistry · (2026) · View on PubMed ↗ · Free PDF ↗
Prognostic significance of cardiac magnetic resonance parameters in hypertrophic cardiomyopathy: a multicentre study.
This multicentre retrospective study examined prognostic value of cardiac MRI parameters in hypertrophic cardiomyopathy (HCM) patients, using feature-tracking CMR to measure left ventricular global longitudinal strain (LVGLS) and left atrial strain (LAS) and quantifying late gadolinium enhancement (LGE). It found that specific CMR-derived measures of myocardial deformation and LGE were independent predictors of major adverse cardiac events (MACE) in HCM. Clinically, these findings support using CMR strain and LGE for improved risk stratification of HCM patients for heart failure, arrhythmias, and sudden cardiac death.
Ho SY, Yiu K, Leung KH et al. · The international journal of cardiovascular imaging · (2026) · View on PubMed ↗ · Free PDF ↗
Transaortic flow is associated with symptom-driven aortic valve replacement in aortic stenosis.
This prospective, multi-centre observational study (PRIMID) investigated the association between transaortic flow-rate (TFR) and symptom-driven aortic valve replacement (AVR) in asymptomatic patients with moderate-to-severe aortic stenosis. It found that transaortic flow-rate derived from stroke volume divided by left ventricular ejection time was associated with subsequent symptom-driven AVR during follow-up. This is significant because it suggests that flow physiology measured by imaging may help identify asymptomatic patients at higher risk who may benefit from earlier intervention.
Pallikadavath S, Hogrefe K, Kelly DJ et al. · The international journal of cardiovascular imaging · (2026) · View on PubMed ↗ · Free PDF ↗
Left ventricular remodeling by cardiac magnetic resonance in children with advanced chronic kidney disease: an analysis of the Chronic Kidney Disease in Children (CKiD) study.
This exploratory analysis used cardiac MRI from the Chronic Kidney Disease in Children (CKiD) study to characterize left ventricular remodeling and myocardial strain in children with advanced chronic kidney disease (CKD). It found that pediatric advanced CKD was associated with adverse LV structural and functional changes measurable by CMR, including abnormal myocardial strain patterns. The significance is that CMR may detect early cardiovascular involvement in children with CKD more sensitively than conventional approaches, informing future risk assessment and intervention strategies.
Reyes LZ, Roem J, Lang SM et al. · Pediatric nephrology (Berlin, Germany) · (2026) · View on PubMed ↗ · Free PDF ↗
Associations of CMR-based pulse wave velocity and aortic distensibility with infrarenal ultrasound-based aortic parameters in the Hamburg City Health Study.
This study used Hamburg City Health Study participants to relate cardiac magnetic resonance (CMR)–derived pulse wave velocity (PWV) and aortic distensibility (AD) to infrarenal abdominal aortic ultrasound measurements for ectasia/aneurysm risk stratification. Higher CMR PWV and altered AD were associated with worse infrarenal ultrasound aortic parameters, supporting CMR vascular stiffness as a screening-relevant marker for abdominal aortic aneurysm risk. These findings suggest that CMR-based vascular biomechanics could improve noninvasive cardiovascular risk stratification beyond conventional risk factors for AAA detection.
Riedl KA, Di Carluccio E, Lund G et al. · Clinical research in cardiology : official journal of the German Cardiac Society · (2026) · View on PubMed ↗ · Free PDF ↗
Glycemia, Diabetes & LV Remodeling (CMR)
Glycemic Status, Cardiac Structure, and Function by Magnetic Resonance Imaging: The Jackson Heart Study.
This study assessed how glycemic status and related markers relate to left ventricular (LV) remodeling in Black adults from the Jackson Heart Study using cardiac magnetic resonance (CMR) measures including Eulerian peak systolic circumferential strain, LV mass, volumes, ejection fraction, and a LV remodeling index. The abstract indicates that glycemic markers were evaluated for associations with LV remodeling, supporting a link between glycemic status and subclinical myocardial dysfunction detectable by CMR. These findings are clinically significant because they suggest CMR-derived remodeling metrics may help identify early heart-failure risk in Black adults with diabetes-related glycemic abnormalities.
Kaze AD, Ani C, Fox ER et al. · Journal of the American Heart Association · (2026) · 1 citations · View on PubMed ↗ · Free PDF ↗
Pediatric Cardiac Tumors (Fibromas) Natural History
Growth of Cardiac Fibromas During Infancy.
This retrospective single-center study examined the natural history of cardiac fibromas in 36 infants and children using serial cardiovascular magnetic resonance (CMR) and/or cardiac computed tomography (CT) before and/or after surgery. The key finding is that cardiac fibromas can demonstrate measurable growth over time rather than remaining stable, challenging the historical assumption of size stability. Scientifically and clinically, this supports closer longitudinal imaging surveillance and may inform timing and risk stratification for intervention in pediatric fibroma patients.
Jurow K, Sperotto F, Geva T et al. · Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · (2026) · View on PubMed ↗ · Free PDF ↗
Coronary Aneurysms & Imaging-Guided Conservative Management
Giant Coronary Artery Aneurysms and Severe Biventricular Failure: Multimodality Imaging-Guided Conservative Management.
This case report studied a 35-year-old man with acute heart failure and giant multivessel coronary artery aneurysms using multimodality imaging (transthoracic echocardiography, coronary CT angiography, and CMR with late gadolinium enhancement). The key finding was that CMR showed transmural late gadolinium enhancement limited to the anterior and lateral walls with partial recovery of biventricular function under conservative management guided by imaging. This is significant because it illustrates an imaging-guided rationale for nonstandard conservative treatment in giant coronary aneurysm–associated biventricular failure.
Davila Flores D, Pitta Acevedo M, Vargas Cabrera O et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗
Hypertrophic Cardiomyopathy (HCM) Vascular Mechanisms & Risk
Vascular changes in hypertrophic cardiomyopathy.
This review studied vascular changes in hypertrophic cardiomyopathy (HCM) by synthesizing human evidence on (micro)vascular function and structural vascular remodeling across disease severities. The key finding is that HCM involves both cardiac and peripheral vascular dysfunction and structural vascular abnormalities that track with progression, fibrosis, and clinical outcomes. The scientific significance is that it consolidates assessment modalities for (micro)vascular disease in HCM and supports vascular mechanisms as potential targets for risk prediction and therapy.
Visch JE, Nassar A, Burchell G et al. · Cardiovascular research · (2026) · View on PubMed ↗ · Free PDF ↗
Impact of type 2 diabetes on myocardial mechanics, fibrosis, and prognosis in hypertrophic cardiomyopathy: A cardiac magnetic resonance study.
This retrospective cohort CMR study evaluated whether coexisting type 2 diabetes mellitus (T2DM) worsens myocardial mechanics, fibrosis, and prognosis in hypertrophic cardiomyopathy (HCM) patients. Among 582 HCM patients (127 with T2DM, 455 without), T2DM was associated with worse CMR-derived structural/functional measures and a higher risk of a composite endpoint including sudden cardiac death, aborted SCD, heart transplantation, heart failure hospitalization, and stroke, with mediation analysis implicating CMR parameters in the HbA1c–outcome relationship. Clinically, the findings support integrating CMR biomarkers into risk assessment for HCM patients with T2DM to better identify those at elevated adverse-event risk.
Cao Y, Li Y, Ming Z et al. · International journal of cardiology · (2026) · View on PubMed ↗
Multimodality Assessment for Sudden Cardiac Death Risk Stratification in Non-Ischemic Cardiomyopathy: A Case-Based Framework Integrating Cardiac Magnetic Resonance, Electrophysiologic Observations, and Genetics.
This case-based framework article proposes multimodality sudden cardiac death (SCD) risk stratification in non-ischemic cardiomyopathy (NICM) by integrating cardiac magnetic resonance (CMR), electrophysiologic observations, and genetics. It emphasizes that CMR—especially late gadolinium enhancement (LGE)—captures myocardial fibrosis and refines arrhythmic risk beyond left ventricular ejection fraction alone, while acknowledging that CMR alone is insufficient for complete risk characterization. Scientifically and clinically, the framework aims to improve identification of patients who may benefit from ICD therapy and reduce inappropriate ICD implantation by combining imaging, physiologic, and genetic information.
Litt MJ, Oraii A, Garcia FC et al. · Indian pacing and electrophysiology journal · (2026) · View on PubMed ↗ · Free PDF ↗
Pregnancy-Associated MINOCA & Acute Cardiac Care
Peripartum cardiomyopathy presenting as postpartum cardiogenic shock: a multimodality imaging approach.
This case studied peripartum cardiomyopathy (PPCM) presenting as postpartum cardiogenic shock in a patient evaluated with multimodality imaging. The report highlights complementary roles of computed tomography and cardiac magnetic resonance (CMR) to rapidly recognize PPCM and exclude alternative etiologies in acute heart failure. The significance is that early, structured imaging with CT plus CMR can improve diagnostic confidence and guide urgent management in life-threatening postpartum cardiogenic shock.
Pretelt ECG, Romanque P, Alegría Bobadilla J et al. · The international journal of cardiovascular imaging · (2026) · View on PubMed ↗
Pregnancy-associated MINOCA: Diagnostic challenges and emergency management in young women.
This review focused on pregnancy-associated myocardial infarction with nonobstructive coronary arteries (MINOCA) in young women, emphasizing diagnostic pitfalls and emergency management during pregnancy and the early postpartum period. It highlights that hypertensive disorders of pregnancy, gestational diabetes mellitus, antiphospholipid syndrome, inherited thrombophilia, and spontaneous coronary artery dissection are increasingly recognized contributors, but direct mechanistic MINOCA evidence remains uneven. The review is significant because it provides an evidence-informed framework for urgent evaluation and management of a high-risk, under-mechanistically clarified condition in pregnancy.
Abdu FA · The American journal of emergency medicine · (2026) · View on PubMed ↗
CMR Radiomics & AI for Cardiomyopathy
Cardiac Magnetic Resonance Radiomics for Diagnosis, Phenotyping and Risk Stratification of Cardiomyopathies.
This systematic review evaluated evidence for CMR radiomics—quantitative image-feature extraction from routine CMR—for diagnosis, phenotyping, and risk stratification across cardiomyopathies. Across included studies, CMR radiomics features improved characterization of cardiomyopathy phenotypes and showed potential for prognostic risk prediction compared with conventional visual CMR assessment. Clinically, this supports radiomics as an emerging, data-driven adjunct to CMR that may refine diagnosis and outcome prediction in cardiomyopathy care.
Granitto C, Hoxha K, Forasassi G et al. · Healthcare (Basel, Switzerland) · (2026) · View on PubMed ↗ · Free PDF ↗
Left Ventricular Non-Compaction (LVNC) Remodeling Metrics
Absolute myocardial mass difference and ventriculo-arterial coupling in morphologically defined left ventricular non-compaction: A multiparametric cardiovascular magnetic resonance study.
This retrospective multiparametric CMR study examined 99 patients with morphologically defined left ventricular non-compaction (LVNC) meeting Petersen and Grothoff criteria and 66 frequency-matched controls to test whether absolute myocardial mass difference (AD) reflects structural-functional remodeling. Absolute myocardial mass difference was associated with hemodynamic and flow-related CMR parameters, supporting AD as a marker of dynamic remodeling rather than relying solely on static morphologic LVNC thresholds. Scientifically, this could refine LVNC assessment and improve understanding of how myocardial structure adapts to altered ventricular-arterial coupling.
Bulut SSD, Emir SN · Acta radiologica (Stockholm, Sweden : 1987) · (2026) · View on PubMed ↗
Post-STEMI Remodeling Prediction via CMR Hemodynamics
Hemodynamic forces provide incremental predictive value for left ventricular remodeling after STEMI.
This multicenter CMR study followed 147 patients after ST-segment elevation myocardial infarction (STEMI), performing CMR within 7 days and again at 5 months post–percutaneous coronary intervention (PCI), to evaluate whether CMR-derived hemodynamic forces (HDF) predict adverse left ventricular remodeling (ALVR). Baseline HDF parameters provided incremental predictive value for ALVR (defined as ≥15% increase in left ventricular end-systolic volume) beyond conventional clinical and standard CMR measures. The results suggest that incorporating CMR hemodynamic forces could improve early identification of patients at risk for post-STEMI remodeling and guide risk-adapted follow-up.
Hu M, Yue X, Chen Y et al. · Magnetic resonance imaging · (2026) · View on PubMed ↗
Pediatric Congenital Heart Disease Follow-up (Tetralogy of Fallot)
Echocardiographic Trajectories of Right Ventricular Size and Function in Children Following Tetralogy of Fallot Repair: A Decade of Stability.
This single-center retrospective cohort study assessed echocardiographic trajectories of right ventricular (RV) size and function in children across the first decade after tetralogy of Fallot repair (TOFr). RV remodeling measures were relatively stable over time, indicating a decade of stability in RV size/function trajectories following repair despite ongoing pulmonary regurgitation-related volume load. This is clinically important for counseling families and for optimizing long-term surveillance strategies after TOFr.
Galan JA, Jones AL, Numata R et al. · Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography · (2026) · View on PubMed ↗
Immune Checkpoint Inhibitor (ICI) Cardiotoxicity Management
Immune Checkpoint Inhibitor-Associated Cardiovascular Toxicity in Melanoma: Current Evidence and Practical Clinical Management.
This narrative review summarized current evidence and practical clinical management for immune checkpoint inhibitor (ICI)–associated cardiovascular toxicity in melanoma patients. It emphasizes that myocarditis is the most severe and best-characterized complication, while a broader spectrum—including pericardial disease, arrhythmias/conduction abnormalities, heart failure, Takotsubo syndrome, and vascular events—also occurs and can be life-threatening. The review is significant because it translates emerging evidence into actionable management considerations for clinicians treating melanoma with ICIs.
Bottardi A, Busin G, Nguyen L et al. · Cancers · (2026) · View on PubMed ↗
Muscle Metabolism & Therapeutics in Dystrophy (HMB)
β-hydroxy-β-methylbutyrate improves fast-twitch muscle function, histopathology and mitochondrial respiration in the D2.mdx dystrophic mouse.
This preclinical study tested whether β-hydroxy-β-methylbutyrate (HMB) supplementation improves fast-twitch muscle outcomes in D2.mdx dystrophic mice, using functional testing, histopathology, and mitochondrial respiration assays. HMB improved fast-twitch muscle function and histopathological measures and enhanced mitochondrial respiration compared with untreated dystrophic controls. These findings support HMB as a potential therapeutic strategy targeting mitochondrial dysfunction in dystrophic muscle, with relevance to Duchenne muscular dystrophy biology.
Giourmas N, Lalunio H, Calzoni M et al. · The Journal of physiology · (2026) · View on PubMed ↗ · Free PDF ↗
Infectious/Geographic Cardiomyopathy (Chagas) & Imaging
Chagas Cardiomyopathy: New-Onset Biventricular Failure and Refractory Ventricular Arrhythmias.
This JACC Case Reports article described two clinical cases of Chagas cardiomyopathy presenting with new-onset biventricular failure and refractory ventricular arrhythmias in men from El Salvador. In both cases, cardiac imaging showed nonischemic features (including late gadolinium enhancement) and Trypanosoma cruzi serology supported the diagnosis, with one patient requiring inotropic support and discharge on guideline-directed therapy plus a wearable cardioverter-defibrillator. The report is significant because it highlights diagnostic and management considerations for under-recognized Chagas disease in the United States, particularly when severe ventricular dysfunction and arrhythmias occur.
Metri AA, Rehman OU, Kaiprath AR et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗
Pediatric Cardiac Screening in Genetic Syndromes (NF1)
Cardiac involvement in neurofibromatosis type 1: real-world baseline and follow-up findings from a tertiary single-center cohort.
This tertiary single-center cohort study evaluated pediatric neurofibromatosis type 1 (NF1) patients (n=114) to determine the prevalence and spectrum of cardiac abnormalities and their associations with demographic/clinical parameters, using ECG, echocardiography, blood pressure, and Holter/cardiac MRI when indicated. Cardiac abnormalities were detected at baseline in a substantial fraction of children and were assessed longitudinally with follow-up echocardiography, enabling characterization of real-world cardiac involvement in NF1. The findings are clinically important for informing screening and follow-up strategies for cardiac complications in children with NF1.
Öz Yıldız S, İmanlı M, Aykan HH et al. · European journal of pediatrics · (2026) · View on PubMed ↗
Generated automatically on September 26, 2026. Covers PubMed articles published September 19, 2026 – September 26, 2026. Summaries are AI-generated; always consult the original publication for clinical or research decisions.