What's New in Cardiac MRI? — September 27, 2026
AI-summarised digest of 61 PubMed articles on Cardiac MRI published in the last 7 days.
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What’s New in Cardiac MRI?
September 27, 2026 · 61 articles · 15 research themes · covering September 20, 2026 – September 27, 2026
Overview
Across this week’s set, cardiac imaging—especially CMR—continues to shift from “diagnosis only” toward quantitative, longitudinal risk modeling. Multiple studies used CMR-derived measures (strain, T1/ECV, LGE patterns, and novel remodeling metrics) to detect subclinical injury and predict outcomes in diverse cardiomyopathies and post–myocardial infarction states. Examples include nonischemic late gadolinium enhancement after MI, feature-tracking strain and LGE for HCM event prediction, and hemodynamic/force-based CMR parameters to anticipate adverse remodeling after STEMI. Together, these works reinforce that tissue characterization and mechanics-based biomarkers can identify higher-risk patients even when conventional clinical markers look reassuring.
A second dominant theme is the expanding diagnostic and mechanistic landscape of cardiac amyloidosis. Several case reports and cohort-level studies highlight both common and rare amyloid subtypes (ATTR, AL, and ApoA-IV), emphasizing diagnostic pitfalls such as false-negative pyrophosphate scans, imaging mimicry of hypertrophic cardiomyopathy or malignancy, and discordance between hematologic response and cardiac recovery. Mechanistically, mitochondrial dysfunction appears linked to amyloid burden in ATTRwt, while native T1 mapping thresholds are proposed to standardize diagnosis and risk stratification across the ATTR spectrum. In parallel, arrhythmia/conduction phenotypes are increasingly captured with objective monitoring (e.g., loop recorders) and even wearable technology, supporting earlier detection and more tailored surveillance.
Finally, the digest shows a clear push toward better “workflow” medicine: improved imaging protocols (motion-robust T1 mapping, dose-sparing contrast), computational advances (radiomics, deep learning for segmentation/biomarkers, real-time 3D motion-field reconstruction), and multimodality triage strategies for complex syndromes like coronary microvascular dysfunction and MINOCA/ANOCA. These efforts aim to reduce uncertainty, improve patient tolerance, and connect imaging outputs to actionable clinical decisions—whether selecting patients for confirmatory testing, refining valve performance assessment beyond gradients, or integrating fibrosis imaging with electrophysiology/genetics for sudden cardiac death prevention.
Cardiac MRI/CT Quantitative Biomarkers & Imaging Methods
Feasibility of Continuous Ventricular Volumetric Quantification in Arrhythmias using Real-Time 3D CMR-MOTUS.
The study evaluated the feasibility of continuous beat-to-beat 3D real-time motion field reconstruction for ventricular volumetric quantification in patients with premature ventricular contractions/arrhythmias using real-time 3D CMR-MOTUS. The key finding was that 3D real-time motion-field reconstruction enabled continuous volumetric quantification across beats despite arrhythmia-related beat-to-beat variability that undermines conventional binned cine CMR. This supports a new CMR approach for capturing clinically relevant ventricular dynamics in arrhythmic patients without relying on heartbeat averaging.
Olausson TE, Terpstra ML, Ahmad R et al. · Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · (2026) · View on PubMed ↗
Strain Rate Angle Distribution as an Indicator of Post-Infarct Myocardial Remodeling: Proof-of-Concept of a Novel Application of the MRI Derived Strain Rate Tensor Field.
The proof-of-concept study developed and applied a novel MRI-derived strain rate tensor field approach—based on converting tissue phase mapping (TPM) velocity-encoded MRI data—to assess post-infarct left ventricular (LV) remodeling in a rat myocardial infarction model. The strain rate angle distribution provided a practical, multidirectional indicator of LV remodeling beyond conventional strain metrics. This technique could improve mechanistic and quantitative assessment of myocardial recovery or deterioration after infarction and support more sensitive preclinical evaluation of therapies.
Totland L, Bendiksen BA, Nordén ES et al. · Magnetic resonance in medicine · (2026) · View on PubMed ↗ · Free PDF ↗
Evaluating the Accuracy and Efficiency of Virtual Reality Segmentation for Black-Blood Fetal Cardiac MRI.
This retrospective feasibility study evaluated a virtual reality–based volumetric segmentation pipeline (Elucis, Realize Medical) for black-blood fetal cardiac MRI to generate 3D congenital heart disease (CHD) models. The key finding was that the approach could be applied to fetal cardiac MRI datasets for CHD screening model generation, addressing limitations of fetal echocardiography related to fetal positioning and maternal anatomy. Scientifically, it suggests a workflow for more efficient, standardized segmentation of fetal cardiac MRI that could improve downstream CHD assessment and planning.
Azar S, Friesen R, Rejeti SBY et al. · Pediatric cardiology · (2026) · View on PubMed ↗
Towards Faster Fetal 3D CINE Cardiac MRI Reconstruction Using Region-Optimized Virtual Coils (ROVir).
This feasibility study evaluated a computationally efficient 3D balanced SSFP (bSSFP) fetal cardiac MRI reconstruction pipeline in 10 volunteers using region-optimized virtual coils (ROVir) for coil compression, compared with singular value decomposition (SVD) coil compression. ROVir reduced radial streaking artifacts, increased effective temporal resolution, and improved diagnostic image quality versus the prior SVD-based approach. Faster, higher-quality fetal 3D cine CMR reconstruction could improve clinical assessment of fetal cardiac function while reducing reconstruction burden.
Piek M, Töger J, Heiberg E et al. · Magnetic resonance in medicine · (2026) · View on PubMed ↗ · Free PDF ↗
CT-derived myocardial extracellular volume: current evidence, clinical utility, and the emerging role of photon-counting CT-a systematic review.
This PRISMA-compliant systematic review evaluated the evidence and clinical utility of CT-derived myocardial extracellular volume (ECV) as a biomarker of diffuse fibrosis, focusing on its relationship to cardiac magnetic resonance (CMR) ECV as the reference standard. The review synthesized data from studies up to December 2025 and highlighted the emerging role of photon-counting CT for more accurate ECV estimation. If validated, CT-derived ECV could broaden access to diffuse fibrosis quantification and integrate myocardial tissue characterization into routine cardiac CT workflows.
D’Argenzio J, Stucchi F, Tambè V et al. · European radiology experimental · (2026) · View on PubMed ↗ · Free PDF ↗
Cardiac Amyloidosis (ATTR/AL and rare subtypes)
Myocardial mitochondrial morphology and oxidative phosphorylation capacity in wild-type transthyretin amyloid cardiomyopathy.
This study examined how amyloid deposition affects myocardial mitochondrial morphology and oxidative phosphorylation capacity in wild-type transthyretin amyloid cardiomyopathy (ATTRwt) patients using electron microscopy and high-resolution respirometry on endomyocardial biopsies. The key finding was that mitochondrial structural features and oxidative phosphorylation capacity were associated with measures of amyloid load (assessed by stereological counting, cardiac resonance imaging, and echocardiography). These results link ATTRwt amyloid burden to mitochondrial dysfunction, providing mechanistic insight that could inform future therapeutic targeting of oxidative metabolism in ATTRwt.
Ladefoged B, Fensman S, Deutch F et al. · Journal of molecular and cellular cardiology · (2026) · View on PubMed ↗
Native T1 for Diagnosis and Risk Prediction in Amyloid Transthyretin Cardiomyopathy: An Observational Study on 1,675 Subjects.
This observational study of 1,675 individuals evaluated native T1 mapping thresholds and prognostic strata across the ATTR spectrum and compared diagnostic/prognostic performance with extracellular volume (ECV). The key finding was that native T1 provided contrast-free diagnostic discrimination and risk stratification across asymptomatic TTR-variant carriers, extracardiac ATTR, and stages of early to advanced ATTR cardiomyopathy, with performance benchmarked against ECV. Clinically, it helps standardize native T1-based interpretation for ATTR diagnosis and risk prediction across diverse disease stages.
Aimo A, Sheikh A, Kakhi S et al. · JACC. Cardiovascular imaging · (2026) · View on PubMed ↗
Epicardial Amyloidoma Mimicking Secondary Cardiac Lymphoma: A Sneeze Away From the Diagnosis.
This case studied an epicardial amyloidoma mimicking malignant cardiac infiltration in a man with indolent B-cell lymphoma and monoclonal gammopathy. Multimodality imaging (echocardiography, cardiac MRI with marked enhancement and increased extracellular volume, and PET/bone scintigraphy that were nondiagnostic) led to suspicion for secondary cardiac lymphoma or Erdheim-Chester disease, but surgical biopsy revealed Congo red–positive amyloid consistent with an amyloidoma. The clinical significance is that localized cardiac amyloid deposition can closely imitate lymphoma on imaging, so tissue diagnosis is crucial when extracardiac malignancy and a cardiac mass coexist.
Vella A, Disabato G, Roncoroni L et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗
Apolipoprotein A-IV Cardiac Amyloidosis as a Diagnostic Pitfall: Beyond the Noninvasive Algorithm.
This case studied apolipoprotein A-IV (ApoA-IV) cardiac amyloidosis as a diagnostic pitfall in a 71-year-old man with reduced kidney function presenting with new heart failure, concentric LV hypertrophy, and an apical-sparing strain pattern. Despite infiltrative cardiac MRI findings, negative bone scintigraphy and negative monoclonal protein screening, endomyocardial biopsy followed by mass spectrometry–based proteomics identified ApoA-IV amyloid. The significance is that non-transthyretin/non–light-chain amyloidoses can evade standard noninvasive algorithms, and proteomic typing of biopsy tissue may be required for correct diagnosis and management.
Koppelaar AJ, Zwetsloot PP, von der Thüsen JH et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗
Multimodality Imaging Reveals Rare Hereditary Transthyretin Amyloidosis Mimicking Hypertrophic Cardiomyopathy.
This case studied rare hereditary transthyretin (TTR) cardiac amyloidosis in a 52-year-old Moroccan woman initially diagnosed with nonobstructive hypertrophic cardiomyopathy. Cardiac MRI showed asymmetric hypertrophy with papillary muscle involvement plus markedly elevated native T1 and extracellular volume, and bone scintigraphy demonstrated intense cardiac tracer uptake consistent with ATTR. The report emphasizes that multimodality imaging and subsequent nuclear/genetic evaluation can distinguish hereditary ATTR from HCM phenocopies in younger patients with unexplained ventricular hypertrophy.
Panelo M, Tuya-Acosta Y, Soto-Priore A et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗
Transthyretin Cardiac Amyloidosis in a Safety-Net Hospital: A Case Series of 10 Afro-Caribbean Patients.
This case series studied transthyretin cardiac amyloidosis (ATTR-CA) in 10 Afro-Caribbean patients diagnosed at a safety-net hospital, a population with a reported high prevalence of the Val122Ile (V142Ile) variant. Seven patients presented with heart failure and three with alternative manifestations (including syncope with high-degree AV block and pericardial tamponade), and all had positive 99mTc-PYP scans with supportive cardiac MRI findings. The significance is that ATTR-CA is likely underdiagnosed in Afro-Caribbean communities and that PYP-based imaging plus MRI can facilitate earlier recognition of variant-associated disease.
Rattan K, Allison EL, Palmer WA et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗
Donut Morphology of Cardiac Amyloidosis: A Glazed Over Diagnosis.
This case studied a “donut morphology” pattern of transthyretin cardiac amyloidosis in a 74-year-old man with HFpEF, atrial fibrillation, and bilateral carpal tunnel syndrome who had a false-negative cardiac amyloid radionuclide imaging study elsewhere. Cardiac MRI revealed isolated circumferential basal wall thickening with localized subendocardial late gadolinium enhancement and extracellular volume changes, consistent with focal/diffuse-incomplete amyloid infiltration. The clinical significance is that technetium-99m pyrophosphate scintigraphy can be falsely negative in early or nondiffuse ATTR, so MRI phenotype should prompt reconsideration and further diagnostic evaluation.
Aggarwal P, Alpert C, Davies D · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗
When Hematologic Response Does Not Translate to Cardiac Recovery in AL Amyloidosis.
This case studied the discordance between hematologic response and cardiac recovery in AL (light-chain) amyloidosis in a 66-year-old woman with dyspnea and chronic edema. Although daratumumab-based chemotherapy substantially reduced free λ light chains after plasma cell myeloma was confirmed by bone marrow biopsy, cardiac imaging supported persistent infiltrative cardiomyopathy and recovery did not occur. The significance is that clinicians should not rely solely on hematologic response as a surrogate for cardiac improvement in advanced AL cardiac involvement.
Futela P, Vinod P, Pushparaji B et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗
Rare Hereditary Cardiac Amyloidosis Treated With SGLT2 Inhibitor: Beyond ATTR/AL.
This case studied a rare hereditary cardiac amyloidosis treated with an SGLT2 inhibitor in a 61-year-old man with progressive NYHA class III heart failure and a family history suggestive of amyloidosis. Cardiac MRI and echocardiography supported cardiac amyloidosis, light-chain CA was excluded, and genetic testing identified an apolipoprotein (Apo) mutation consistent with hereditary amyloid cardiomyopathy; the patient was treated beyond the usual ATTR/AL framework using an SGLT2 inhibitor. The significance is that SGLT2 inhibition may be considered as a therapeutic option in selected non-ATTR/non-AL hereditary amyloid cardiomyopathies, though evidence remains limited.
Voran JC, Radić Ž, Kilian LS et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗
Hereditary Transthyretin Cardiac Amyloidosis With Severe Left Ventricular Outflow Tract Obstruction Mimicking Hypertrophic Obstructive Cardiomyopathy.
This case studied hereditary transthyretin cardiac amyloidosis presenting with severe LVOT obstruction in a 49-year-old man initially diagnosed with hypertrophic obstructive cardiomyopathy. Echocardiography showed septal hypertrophy with severe LVOT obstruction, but cardiac MRI demonstrated diffuse subendocardial late gadolinium enhancement and genetic testing identified a pathogenic TTR variant, while bone scintigraphy showed low-grade myocardial uptake. The significance is that ATTR can produce obstructive physiology that mimics HOCM, so amyloidosis should be considered when imaging and genetics suggest a TTR etiology despite atypical scintigraphy.
Nissan B, Magadale N, Kaplinskiy V et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗
Smartwatch-Detected Sinus Tachycardia Unmasking AL Cardiac Amyloidosis in a Young Adult.
This case studied smartwatch-detected sinus tachycardia as an early clue to AL cardiac amyloidosis in a 36-year-old woman with minimal nonspecific symptoms. Wearable alerts prompted further evaluation, and cardiac MRI suggested amyloidosis that was confirmed as Mayo Clinic stage III immunoglobulin A lambda AL by laboratory testing and histology. The significance is that wearable health technology can accelerate diagnosis in younger patients with heterogeneous AL presentations, potentially enabling earlier treatment and improved outcomes.
O’Dea G, O’Gorman P, Giblin GT · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗
Amyloid Light Chain Amyloidosis Involving the Heart and Temporal Arteries, Mimicking Giant Cell Arteritis.
This case report studied a 74-year-old man with amyloid light-chain (AL) amyloidosis involving the heart and temporal arteries that initially mimicked giant cell arteritis. Diagnosis was confirmed by temporal artery biopsy after cardiac magnetic resonance suggested amyloidosis, and treatment with bortezomib, cyclophosphamide, and dexamethasone was initiated. The report highlights that AL cardiac amyloidosis can present with temporal arteritis-like symptoms and that tissue confirmation plus plasma-cell–directed therapy can be crucial for timely, life-prolonging management.
Rashed A, Fernandes E, Saito R et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗
Successful Heart Transplantation in a Patient With Triple Infiltrative Cardiomyopathy: Sarcoidosis, AL and TTR Amyloidosis.
This case report studied a patient with triple infiltrative cardiomyopathy—cardiac sarcoidosis plus both AL and transthyretin (TTR) amyloidosis—after heart transplantation. The coexistence of sarcoidosis and amyloid types was identified in myocardial tissue using liquid chromatography tandem mass spectrometry, supported by advanced cardiac magnetic resonance and fluorodeoxyglucose positron emission tomography. The findings are clinically significant because they show that multiple infiltrative processes can coexist in one patient and that multimodality imaging and definitive proteomic typing are needed to guide management.
Nikolaidis LA, Hassan OA, Khariton Y et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗
Apolipoprotein A-IV Cardiac Amyloidosis Presenting as Massive Ventricular Wall Thickening Mimicking Hypertrophic Cardiomyopathy.
This case report studied a 64-year-old woman with apolipoprotein A-IV (AApoAIV) cardiac amyloidosis presenting as massive ventricular wall thickening that mimicked hypertrophic cardiomyopathy. Multimodality imaging suggested infiltrative cardiomyopathy (diffuse late gadolinium enhancement, abnormal nulling, elevated T1, and an apical-sparing strain pattern), while technetium-99m pyrophosphate scintigraphy showed no myocardial uptake, helping distinguish it from transthyretin/AL patterns. The report is significant because it emphasizes that rare amyloid subtypes like AApoAIV can masquerade as hypertrophic cardiomyopathy and require careful imaging-based differentiation.
Coderre R, Tersalvi G, Adigun RO et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗
Unmasking AL Cardiac Amyloidosis During Familial Cardiomyopathy Screening.
This case report studied a 65-year-old asymptomatic man undergoing familial cardiomyopathy screening who was ultimately found to have AL cardiac amyloidosis. Despite bone scintigraphy showing no cardiac tracer uptake (Perugini grade 0) and cardiac magnetic resonance showing biventricular hypertrophy with normal extracellular volume plus late gadolinium enhancement, the clinical suspicion for infiltrative disease was raised during screening. The study is important because it shows that AL amyloidosis may be unmasked during family screening and that normal extracellular volume and negative bone scintigraphy do not fully exclude AL cardiac involvement.
Barberis Barcia G, Toranzo-Nieto I, González-Calle V et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗
Navigating the irradiated ureter: multi-institutional outcomes of robotic ureteral reconstruction for radiation-induced strictures.
This multi-institutional retrospective study evaluated robotic ureteral reconstruction outcomes for radiation-induced ureteral strictures using the CORRUS database (2018–2024). The key finding was that robotic reconstruction is feasible and provides measurable surgical outcomes in patients with strictures caused by prior pelvic radiation. The clinical significance is that minimally invasive robotic reconstruction may offer an option in a technically challenging irradiated field where scarring and impaired tissue mobility complicate conventional surgery.
Lee M, Wegner G, Santos R et al. · World journal of urology · (2026) · View on PubMed ↗
p.(V142I)-Associated Variant Transthyretin Amyloid Cardiomyopathy Complicating Complex Congenital Heart Disease: A Lethal Combination.
This case report studied a 51-year-old Nigerian man with complex congenital heart disease (double outlet right ventricle) who developed transthyretin amyloid cardiomyopathy due to the p.(V142I) variant. The key finding was that cardiac amyloidosis was suspected on echocardiography and confirmed by cardiac magnetic resonance and bone scintigraphy, with genetic sequencing showing homozygosity for p.(V142I). The clinical significance is that ATTRv-CM with p.(V142I) can be lethal and may complicate congenital heart disease, underscoring the need for genetic and amyloid evaluation in high-risk patients of African ancestry.
Zathar Z, Choy CH, Al-Sakini N et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗
Exploration of Arrhythmia Burden in Cardiac Amyloidosis Using Implantable Loop Recorders: The EXCALIBUR Study.
The EXCALIBUR study prospectively characterized arrhythmic burden in 110 treatment-naïve patients with newly diagnosed transthyretin amyloid cardiomyopathy (ATTR-CM) or light-chain cardiac amyloidosis (AL-CA) using implantable loop recorders. It aimed to relate objectively measured arrhythmia burden to amyloid subtype and disease characteristics through comprehensive cardiac phenotyping including cardiac magnetic resonance (CMR). Quantifying real-world arrhythmia burden in amyloidosis may improve risk stratification for conduction disease and arrhythmic events.
Ioannou A, Patel R, Mansell J et al. · Journal of the American College of Cardiology · (2026) · 2 citations · View on PubMed ↗ · Free PDF ↗
Cardiomyopathy Phenotyping & Risk Stratification (non-amyloid)
Reduced ALDH2 Activity and Cardiovascular Carbonyl Stress: From Reactive Aldehyde Networks to Coronary Microvascular Obstruction.
This review analyzed whether reduced mitochondrial aldehyde dehydrogenase 2 (ALDH2) activity acts as a susceptibility amplifier for cardiovascular carbonyl stress leading to coronary microvascular obstruction phenotypes after reperfusion. The key finding was that reperfusion-driven reactive oxygen species generate electrophilic aldehydes (e.g., 4-hydroxy-2-nonenal and malondialdehyde) that, in the setting of impaired ALDH2 detoxification, promote lipid peroxidation and downstream microvascular injury. Clinically, this reframes ALDH2 as a modifiable risk amplifier across overlapping reperfusion injury phenotypes (no-reflow, CMR-defined microvascular obstruction, and intramyocardial hemorrhage), suggesting potential benefit from ALDH2-targeted strategies.
Yan Z, Pu X, Cai Y et al. · Cardiovascular toxicology · (2026) · View on PubMed ↗
Endomyocardial fibrosis in adults: multimodality imaging phenotype and independent predictors of mortality.
This retrospective single-center cohort study characterized adult endomyocardial fibrosis (EMF) using multimodality imaging (including echocardiography and cardiac magnetic resonance when available) and assessed longitudinal evolution and predictors of all-cause mortality. The key finding was identification of independent clinical/imaging predictors of mortality in adults with EMF over long follow-up. These findings improve prognostic counseling and may guide risk-adapted management strategies for this rare restrictive cardiomyopathy.
Hotta VT, Romero CE, Madrini V et al. · International journal of cardiology · (2026) · View on PubMed ↗ · Free PDF ↗
Impaired myocardial oxygen metabolism and energy efficiency in patients with dilated cardiomyopathy.
The study assessed myocardial oxygen metabolism and mechano-energetic efficiency in dilated cardiomyopathy (DCM) patients (n=49) versus matched controls (n=23) using non-contrast CMR measures including cine for LVEF and LVGLS, pre/post-contrast T1 mapping for extracellular volume (ECV), and first-pass perfusion imaging for semi-quantification. The key finding was that DCM patients exhibited impaired myocardial oxygen metabolism and reduced energy efficiency compared with controls. This supports CMR-derived oxygen-metabolism/energy-efficiency metrics as potential biomarkers for functional impairment and prognosis in DCM.
Dai L, Qiao J, Wang K et al. · Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · (2026) · View on PubMed ↗ · Free PDF ↗
Impact of type 2 diabetes on myocardial mechanics, fibrosis, and prognosis in hypertrophic cardiomyopathy: A cardiac magnetic resonance study.
This retrospective cardiac magnetic resonance (CMR) cohort study assessed how coexisting type 2 diabetes mellitus (T2DM) affects myocardial mechanics, fibrosis, and prognosis in 582 hypertrophic cardiomyopathy (HCM) patients (127 with T2DM, 455 without). T2DM was associated with worse CMR-derived myocardial mechanics and greater fibrosis burden, and mediation analysis suggested CMR parameters (including HbA1c-linked pathways) contributed to the HbA1c–outcome relationship. These findings support using CMR biomarkers to refine risk stratification and understand mechanisms by which T2DM worsens outcomes in HCM.
Cao Y, Li Y, Ming Z et al. · International journal of cardiology · (2026) · View on PubMed ↗
Multimodality Assessment for Sudden Cardiac Death Risk Stratification in Non-Ischemic Cardiomyopathy: A Case-Based Framework Integrating Cardiac Magnetic Resonance, Electrophysiologic Observations, and Genetics.
This case-based framework article integrated cardiac magnetic resonance (CMR) findings—especially late gadolinium enhancement (LGE)—with electrophysiologic observations and genetics to improve sudden cardiac death (SCD) risk stratification in non-ischemic cardiomyopathy (NICM). It emphasizes that LVEF alone misses at-risk patients and can lead to ICD overuse, while multimodality assessment better characterizes arrhythmogenic substrate. Clinically, combining CMR fibrosis imaging with electrophysiology and genetic context may enable more accurate, personalized SCD prevention strategies in NICM.
Litt MJ, Oraii A, Garcia FC et al. · Indian pacing and electrophysiology journal · (2026) · View on PubMed ↗ · Free PDF ↗
Prognostic significance of cardiac magnetic resonance parameters in hypertrophic cardiomyopathy: a multicentre study.
This multicentre retrospective study evaluated prognostic CMR parameters in hypertrophic cardiomyopathy (HCM) patients who underwent CMR between 2008 and 2022 across five sites, using feature-tracking (FT) to derive left ventricular global longitudinal strain (LVGLS) and left atrial strain (LAS) and quantifying late gadolinium enhancement (LGE). The study identified independent CMR predictors of major adverse cardiovascular events (MACE) among LVGLS, LAS, and LGE. If confirmed, CMR FT strain and LGE quantification could refine risk stratification for heart failure, arrhythmias, and sudden cardiac death in HCM.
Ho SY, Yiu K, Leung KH et al. · The international journal of cardiovascular imaging · (2026) · View on PubMed ↗ · Free PDF ↗
Myocardial Fibrosis & Remodeling (LGE/ECV/strain-based)
Weighted gene co-expression network reveals CCND1 as a promising biomarker and therapeutic target for myocardial fibrosis in hypertrophic cardiomyopathy.
Using weighted gene co-expression network analysis (WGCNA) integrated with late gadolinium enhancement (LGE) cardiac magnetic resonance (CMR) fibrosis severity, the study identified fibrotic pathways and regulatory genes in patients with hypertrophic cardiomyopathy (HCM). The key finding was that CCND1 emerged as a promising biomarker and therapeutic target for myocardial fibrosis in HCM. This provides a gene-level candidate for risk stratification and potential antifibrotic intervention in HCM, where fibrosis drives adverse outcomes including ventricular arrhythmias.
Chang L, Gong C, Wu Z et al. · Biochemical and biophysical research communications · (2026) · View on PubMed ↗
Septal Nonischemic Late Gadolinium Enhancement After Myocardial Infarction Is Associated With Adverse Remodeling and Improves Risk Stratification for Heart Failure Outcomes.
This retrospective cohort study analyzed 948 patients with prior myocardial infarction to determine the prevalence, distribution, enhancement patterns, and prognostic value of nonischemic late gadolinium enhancement (NI-LGE) on cardiac magnetic resonance imaging. NI-LGE—defined as midwall or subepicardial enhancement—was present in 8.2% and was associated with adverse cardiac remodeling and improved risk stratification for heart failure outcomes. Clinically, NI-LGE may identify a higher-risk subgroup among post-MI patients even when enhancement is not ischemic in pattern.
Zhou P, Zhao K, Aisikaier K et al. · Journal of the American Heart Association · (2026) · View on PubMed ↗ · Free PDF ↗
Absolute myocardial mass difference and ventriculo-arterial coupling in morphologically defined left ventricular non-compaction: A multiparametric cardiovascular magnetic resonance study.
This retrospective multiparametric CMR study investigated whether absolute myocardial mass difference (AD) reflects structural-functional remodeling in morphologically defined left ventricular non-compaction (LVNC). Among 99 LVNC patients meeting Petersen and Grothoff CMR criteria and 66 matched controls, AD was evaluated for associations with hemodynamic and flow-related parameters, alongside ventriculo-arterial coupling and other CMR measures. If AD tracks dynamic remodeling better than static morphology alone, it could improve CMR-based assessment and risk understanding in LVNC.
Bulut SSD, Emir SN · Acta radiologica (Stockholm, Sweden : 1987) · (2026) · View on PubMed ↗
Coronary Microvascular Dysfunction & MINOCA/ANOCA
Intravascular imaging in myocardial infarction and ischemia with nonobstructive coronary arteries.
This article reviewed the role of intravascular imaging in myocardial infarction with nonobstructive coronary arteries (MINOCA) and angina/ischemia with nonobstructive coronary arteries (ANOCA/INOCA), focusing on optical coherence tomography (OCT) and intravascular ultrasound (IVUS). The key finding was that OCT and IVUS provide complementary mechanistic information—OCT better for thrombus and superficial plaque disruption, IVUS better for plaque burden, positive remodeling, intramural hematoma, and myocardial bridging—with timing-dependent utility in acute versus chronic presentations. Scientifically and clinically, it supports targeted intracoronary imaging during the index angiogram to identify underlying causes when angiography alone is insufficient.
Nishi T, Kume T, Irimpen A et al. · Cardiovascular intervention and therapeutics · (2026) · View on PubMed ↗ · Free PDF ↗
Obstructive Intramural Coronary Amyloidosis: Uncommon or Under-Recognized Cause of Microvascular Angina?
This case studied obstructive intramural coronary amyloidosis (OICA) as a cause of microvascular angina in an 83-year-old man with recurrent ischemic symptoms and persistently elevated troponin despite normal coronary angiography. Endomyocardial biopsy demonstrated extensive transthyretin (ATTR) amyloid deposition almost exclusively in intramural coronary arterioles, establishing OICA as the mechanism. The report highlights that ATTR-OICA can be an under-recognized, biopsy-confirmable cause of ischemia with nonobstructive coronaries and negative noninvasive imaging, informing diagnostic pathways for microvascular angina.
Fazzini L, D’Elia E, Sciatti E et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗
Navigating coronary microvascular dysfunction: an echocardiographic triage algorithm for cardiac magnetic resonance and coronary computed tomography angiography.
This proposed echocardiography-guided multimodality triage algorithm for suspected coronary microvascular dysfunction (CMD) used transthoracic echocardiography measures—global longitudinal strain (GLS) and a Doppler-derived coronary sinus flow (CSF) index—to select patients for confirmatory cardiac magnetic resonance (CMR) and coronary CT angiography. Patients with abnormal initial echocardiographic findings were referred for CMR to obtain definitive tissue characterization and quantitative phase-based assessment. The approach aims to provide a noninvasive pathway that reduces reliance on invasive CMD testing while improving early detection and risk stratification.
Güleşir ME · Journal of ultrasound · (2026) · View on PubMed ↗
Cardiac Inflammation & Myocarditis-like Syndromes
Myocarditis-Like Presentation Leads to DSP Arrhythmogenic Cardiomyopathy Diagnosis: From Variant of Uncertain Significance to Diagnosis.
This JACC Case Reports report described a 38-year-old woman with a myocarditis-like presentation whose diagnostic workup led to desmoplakin (DSP) arrhythmogenic cardiomyopathy. The key finding was that initial genetic testing identified a DSP variant of uncertain significance (VUS) that was later reclassified as likely pathogenic after follow-up CMR showed persistent multifocal nonischemic late gadolinium enhancement. The case highlights the clinical significance of variant reclassification and longitudinal CMR in establishing DSP cardiomyopathy and enabling timely management.
DeLorenzo O, Farkouh F, Alameh I et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗
Herpes simplex virus and kallikrein-related peptidases - a functional connection in Alzheimer’s disease.
The study investigated whether cerebrospinal fluid (CSF) kallikrein-related peptidase 6 (KLK6) is associated with Alzheimer’s disease (AD) biomarkers and with an intrathecal anti–herpes simplex virus (HSV) immune response in patients with AD, and whether HSV-1 infection alters KLK6 expression in cell culture models. CSF KLK6 levels were linked to AD biomarker status and to markers of intrathecal anti-HSV-1/2 immune activity (HSV-AI), and HSV-1 infection modulated KLK6 expression in vitro. These findings support a functional connection between HSV-1 and KLK6 that may help explain pathogen–amyloid/tau interactions in AD and identify KLK6 as a potential biomarker bridging viral immunity and neurodegeneration.
Goldhardt O, Robles CM, Eberl M et al. · Alzheimer’s research & therapy · (2026) · View on PubMed ↗ · Free PDF ↗
Contrast Agents & Imaging Protocol Optimization
Gadopiclenol for Cardiac MRI: Comparison of Myocardial T1 Relaxation Times and Subjective Image Quality at Different Doses in Patients With Anderson-Fabry Disease.
In Anderson-Fabry disease (AFD) patients undergoing 3T cardiac MRI, this observational feasibility study compared myocardial T1 relaxation times and subjective LGE image quality after gadopiclenol administration at two different doses. The key finding was that gadopiclenol produced measurable myocardial T1 shortening and maintained high LGE image quality at reduced gadolinium dose compared with higher-dose administration. This supports gadopiclenol as a potentially dose-sparing contrast agent for cardiac MRI in AFD.
Kollmann AT, Huflage H, Dazeh RS et al. · Investigative radiology · (2026) · View on PubMed ↗
Native myocardial T1 mapping using rapid 1.5T T1FLASH and T1 MOLLI during breath-hold and free-breathing.
This prospective study compared native myocardial T1 mapping performance using rapid 1.5T T1FLASH and T1 MOLLI (with motion correction, T1 MOLLI MOCO) acquired during breath-hold versus free-breathing in 14 healthy adult volunteers. The key finding was that rapid T1FLASH and T1 MOLLI MOCO can be implemented with shorter breath-holds and motion correction strategies to mitigate breathing-related artifacts while maintaining quantitative T1 mapping feasibility. This supports more patient-tolerant CMR T1 mapping protocols, potentially improving data quality in individuals who cannot sustain breath-holds.
Röwer LM, Hussen-Demir Y, Verde PE et al. · BMC cardiovascular disorders · (2026) · View on PubMed ↗ · Free PDF ↗
Arrhythmias & Inherited Electrical Disease
Complete Atrioventricular Block in an HLA-B27-Positive Woman Without Overt Spondyloarthritis.
This case report described a 43-year-old woman with complete atrioventricular block (CAVB) who was HLA-B27 positive but had no overt spondyloarthritis, despite recurrent HLA-B27–associated anterior uveitis and Hashimoto thyroiditis. Comprehensive evaluation including cardiac magnetic resonance imaging, fluorodeoxyglucose positron emission tomography, and extensive genetic testing supported an HLA-B27–associated conduction disease phenotype without classic spondyloarthritis. The report highlights that HLA-B27–related inflammatory mechanisms can present as isolated, severe conduction disease in adults and should be considered in early-onset CAVB workups.
Batista Lage JG, Tavares Pinheiro MV, Ferreira de Souza O et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗
Malignant Early Repolarization Syndrome Unmasked by Acute Respiratory Distress Syndrome in a Young Adult.
This case report studied a previously healthy 24-year-old man with malignant early repolarization syndrome (ERS) unmasked during acute respiratory distress syndrome (ARDS). The key finding was recurrent ventricular fibrillation triggered by short-coupled premature ventricular complexes during hypoxemia and hypokalemia, with ECG showing inferolateral J-point elevation (>0.2 mV) and suppression with quinidine and isoproterenol. The report is significant because it demonstrates how systemic stressors like ARDS can precipitate lethal ERS arrhythmias and supports prompt antiarrhythmic management.
Sah S, Doshi P, Bhandari J et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗
Phenotypic Transition From Danon Disease to Arrhythmogenic Cardiomyopathy: Multimodality and Histopathologic Evidence.
This case report studied a 30-year-old woman with a Danon disease background due to a pathogenic LAMP2 variant who later developed a phenotypic transition toward arrhythmogenic cardiomyopathy. The key finding was that multimodality imaging showed extensive ring-like late gadolinium enhancement and biventricular systolic dysfunction consistent with arrhythmogenic cardiomyopathy, with histopathologic evidence supporting the transition. Scientifically, it highlights that LAMP2-related cardiomyopathy can evolve into an arrhythmogenic phenotype, informing long-term surveillance and risk management.
Quintella Sangiorgi Olivetti N, Belitardo GP, Cerqueira Matheus F et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗
Congenital/Structural Heart Disease & Rare Vascular Anomalies
Complex bilateral coronary artery fistulas with multiple drainage sites: a multimodality imaging case report.
This multimodality imaging case report evaluated a 68-year-old patient with exertional dyspnoea and dizziness to characterize complex bilateral coronary artery fistulas (CAFs) with multiple drainage sites. Coronary angiography and multislice computed tomography demonstrated complex bilateral CAFs arising from both coronary arteries with drainage into the superior vena cava, right atrium, and descending aorta. The case illustrates how combined invasive and CT-based imaging can define anatomy and guide management decisions in rare, high-risk CAF configurations.
Ružičić D, Čanković M, Komazec N et al. · European heart journal. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗
Growth of Cardiac Fibromas During Infancy.
This retrospective single-center study investigated the natural history of cardiac fibromas by identifying infants and children with cardiac fibromas and analyzing serial cardiovascular magnetic resonance (CMR) and/or cardiac computed tomography (CT) before and after surgery. It characterized how fibroma size changes over time, addressing the long-held assumption that unoperated cardiac fibromas remain stable. Understanding growth dynamics can inform surveillance intensity and timing of intervention to reduce risks such as arrhythmias and hemodynamic compromise.
Jurow K, Sperotto F, Geva T et al. · Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · (2026) · View on PubMed ↗ · Free PDF ↗
Cardiac Imaging in Special Populations (pregnancy, pediatrics, CKD, SLE/SS)
Glycemic Status, Cardiac Structure, and Function by Magnetic Resonance Imaging: The Jackson Heart Study.
Using data from the Jackson Heart Study, this analysis examined how glycemic status and related markers relate to left ventricular (LV) remodeling measured by cardiac magnetic resonance imaging in Black adults. Measures including Eulerian peak systolic circumferential strain, LV mass, volumes, ejection fraction, and an LV remodeling index were used to test associations with glycemic markers. The study supports the use of CMR-derived remodeling metrics to detect subclinical myocardial dysfunction linked to diabetes risk in Black populations.
Kaze AD, Ani C, Fox ER et al. · Journal of the American Heart Association · (2026) · 1 citations · View on PubMed ↗ · Free PDF ↗
Peripartum cardiomyopathy presenting as postpartum cardiogenic shock: a multimodality imaging approach.
This case report studied peripartum cardiomyopathy presenting postpartum as cardiogenic shock and evaluated the diagnostic value of computed tomography and cardiac magnetic resonance (CMR). The key finding was that multimodality imaging helped rapidly recognize peripartum cardiomyopathy while excluding alternative etiologies in an acute setting. Clinically, the report supports using CT plus CMR to expedite diagnosis and management decisions in critically ill postpartum patients.
Pretelt ECG, Romanque P, Alegría Bobadilla J et al. · The international journal of cardiovascular imaging · (2026) · View on PubMed ↗
Comparison of cardiac MRI features of fibrosis and strain for early cardiac dysfunction assessment in patients with systemic lupus erythematosus and Sjögren’s syndrome.
This CMR study compared cardiac involvement in systemic lupus erythematosus (SLE) patients with and without coexisting Sjögren’s syndrome (SS) by assessing 36 SLE+SS, 36 SLE-only, and 20 matched healthy controls. It evaluated LV global strain, native T1 and T2, extracellular volume fraction (ECV), and late gadolinium enhancement (LGE) to determine whether SS modifies cardiac dysfunction and remodeling in SLE. The results aim to clarify how SS influences subclinical myocardial injury in SLE and to support CMR-based early detection of cardiac dysfunction.
Yang Z, Wang LL, Meng X et al. · Lupus science & medicine · (2026) · View on PubMed ↗ · Free PDF ↗
Macroalbuminuria as a marker of cardiac damage in patients with type 2 diabetes: insights from multimodality cardiac imaging and biomarkers.
This cross-sectional multimodality imaging and biomarker study assessed whether macroalbuminuria is associated with cardiac structure and function in 49 adults with type 2 diabetes (T2D) and stage 3 chronic kidney disease (CKD), compared with 20 controls. In T2D with macroalbuminuria, circulating myocardial stress/fibrosis-related biomarkers (including soluble suppression of tumorigenicity 2 [sST2]) and cardiac imaging measures from cardiac MRI and transthoracic echocardiography were linked to greater cardiac damage. These findings support macroalbuminuria as a clinically useful marker for identifying T2D patients at higher risk of subclinical myocardial injury.
Olloquiegui XI, Andueza SE, Izco MP et al. · Journal of physiology and biochemistry · (2026) · View on PubMed ↗ · Free PDF ↗
Left ventricular remodeling by cardiac magnetic resonance in children with advanced chronic kidney disease: an analysis of the Chronic Kidney Disease in Children (CKiD) study.
This exploratory analysis of the Chronic Kidney Disease in Children (CKiD) study used cardiac magnetic resonance (CMR) to characterize left ventricular remodeling in children with advanced chronic kidney disease (CKD). The study focused on CMR-derived myocardial morphology and function, including myocardial strain, to relate CKD severity to cardiovascular disease burden. These data could strengthen the role of CMR as a sensitive tool for detecting early pediatric CKD-related cardiac remodeling and guiding risk assessment.
Reyes LZ, Roem J, Lang SM et al. · Pediatric nephrology (Berlin, Germany) · (2026) · View on PubMed ↗ · Free PDF ↗
Pregnancy-associated MINOCA: Diagnostic challenges and emergency management in young women.
This narrative review addressed diagnostic challenges and emergency management of pregnancy-associated myocardial infarction with nonobstructive coronary arteries (MINOCA) in young women. It highlighted that pregnancy-related or pregnancy-amplified conditions—such as hypertensive disorders of pregnancy (HDP), gestational diabetes mellitus (GDM), antiphospholipid syndrome (APS), inherited thrombophilia, and spontaneous coronary artery dissection—can contribute to MINOCA-like presentations, but direct evidence remains limited. Clinically, the review emphasizes heightened diagnostic vigilance and tailored emergency management strategies during pregnancy and the early postpartum period.
Abdu FA · The American journal of emergency medicine · (2026) · View on PubMed ↗
Echocardiographic Trajectories of Right Ventricular Size and Function in Children Following Tetralogy of Fallot Repair: A Decade of Stability.
This single-center retrospective cohort study evaluated echocardiographic trajectories of right ventricular (RV) size and function in children who underwent surgical repair of tetralogy of Fallot (TOF) between March 2012 and December 2023, using at least two echocardiograms obtained at least one year apart over the first decade after repair. The authors found that RV remodeling—reflected in serial echocardiographic measures of RV size and function—was relatively stable across the 10-year post-repair period. These findings suggest that, in pediatric TOF patients, the timing and progression of RV volume-overload remodeling may be more gradual and predictable during childhood, which can inform longitudinal surveillance strategies and risk modeling for later RV dysfunction.
Galan JA, Jones AL, Numata R et al. · Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography · (2026) · View on PubMed ↗
Case Reports & Diagnostic Pitfalls (multimodality mass/infiltration mimics)
Giant Coronary Artery Aneurysms and Severe Biventricular Failure: Multimodality Imaging-Guided Conservative Management.
This JACC Case Reports report evaluated a 35-year-old man with acute heart failure and severe biventricular dysfunction to diagnose and manage giant multivessel coronary artery aneurysms. Multimodality imaging showed giant coronary artery aneurysms with mural thrombi involving all epicardial vessels, with cardiac MRI demonstrating transmural late gadolinium enhancement confined to the anterior and lateral walls and partial recovery of biventricular function under conservative management. The case supports that, in selected patients, imaging-guided conservative strategies may be feasible even with extensive aneurysmal disease and severe initial dysfunction.
Davila Flores D, Pitta Acevedo M, Vargas Cabrera O et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗
Multidisciplinary single stage surgical management of advanced breast carcinoma with concomitant left atrial myxoma.
This case report described multidisciplinary single-stage surgical management of advanced breast carcinoma with a concomitant left atrial myxoma in a 58-year-old woman. Echocardiography incidentally found a left atrial mass, and cardiac MRI plus FDG PET-CT suggested a cardiac neoplasm but could not exclude metastasis, prompting surgical management to address both malignancy and the atrial mass. The report underscores the diagnostic and therapeutic complexity of intracardiac masses in cancer patients and supports coordinated surgical decision-making to mitigate embolic risk.
Haval S, Garg A, Pawar R et al. · Interdisciplinary cardiovascular and thoracic surgery · (2026) · View on PubMed ↗ · Free PDF ↗
Vascular Disease & Atherosclerosis Risk (aorta/AAA/HCM vasculature)
Vascular changes in hypertrophic cardiomyopathy.
This review summarized evidence on vascular changes in hypertrophic cardiomyopathy (HCM), focusing on microvascular and peripheral vascular dysfunction and structural vascular remodeling across disease severity. It collated modalities used to assess vascular function and linked vascular abnormalities to progression, fibrosis, and clinical outcomes. The synthesis emphasizes that vascular pathology is a key contributor to HCM heterogeneity and may offer additional targets for risk stratification and therapy beyond myocardial hypertrophy alone.
Visch JE, Nassar A, Burchell G et al. · Cardiovascular research · (2026) · View on PubMed ↗ · Free PDF ↗
Associations of CMR-based pulse wave velocity and aortic distensibility with infrarenal ultrasound-based aortic parameters in the Hamburg City Health Study.
Using data from the Hamburg City Health Study, this study assessed whether CMR-derived pulse wave velocity (PWV) and aortic distensibility (AD) relate to infrarenal abdominal aortic aneurysm (AAA) risk markers measured by ultrasound. PWV and AD of the ascending and descending aorta were quantified using 2D phase-contrast velocity-encoding CMR, while ultrasound measured infrarenal aortic maximum diameter and peak flow velocity to define ectasia (25–29 mm) and aneurysm (≥30 mm). If CMR metrics correlate with ultrasound-defined infrarenal disease, they could enable improved noninvasive cardiovascular risk stratification for AAA screening.
Riedl KA, Di Carluccio E, Lund G et al. · Clinical research in cardiology : official journal of the German Cardiac Society · (2026) · View on PubMed ↗ · Free PDF ↗
Hemodynamics & Flow Imaging (4D flow, valve performance, forces)
Hemodynamic Flow Signatures: A Novel Paradigm for the Evaluation of Transcatheter Aortic Valve Performance.
This article described a hemodynamic flow–signature paradigm for evaluating transcatheter aortic valve (TAV) performance, centered on whether the implanted valve restores physiological aortic flow. It highlighted that 4D flow CMR can quantify systolic flow displacement (eccentricity), systolic flow reversal ratio (conduit inefficiency), wall shear stress, and energetic efficiency, revealing persistent nonphysiological flow even when transvalvular gradients improve. The framework could improve assessment of TAV success beyond pressure gradients by linking complex flow abnormalities to downstream clinical risk.
Maznyczka A, De Backer O, Bapat VN et al. · Circulation. Cardiovascular interventions · (2026) · View on PubMed ↗ · Free PDF ↗
Transaortic flow is associated with symptom-driven aortic valve replacement in aortic stenosis.
This prospective, multicentre observational study (PRIMID) examined whether transaortic flow-rate (TFR), calculated from stroke volume divided by left ventricular ejection time, is associated with symptom-driven aortic valve replacement (AVR) in asymptomatic patients with moderate-to-severe aortic stenosis (AS). Patients underwent transthoracic echocardiography (TTE), cardiopulmonary exercise testing, and stress CMR, and were followed for symptom-driven AVR with long-term outcomes captured via electronic health records. Demonstrating an association would support TFR as an additional CMR-derived hemodynamic marker to better predict which asymptomatic AS patients will progress to symptomatic AVR.
Pallikadavath S, Hogrefe K, Kelly DJ et al. · The international journal of cardiovascular imaging · (2026) · View on PubMed ↗ · Free PDF ↗
Hemodynamic forces provide incremental predictive value for left ventricular remodeling after STEMI.
This study assessed whether CMR-derived hemodynamic forces (HDF) add predictive value for adverse left ventricular remodeling (ALVR) after ST-segment elevation myocardial infarction (STEMI). In 147 STEMI patients who underwent CMR within 7 days and again at 5 months post–percutaneous coronary intervention (PCI), ALVR was defined as a ≥15% increase in left ventricular end-systolic volume, and multivariable models compared HDF parameters with conventional clinical and CMR risk markers. If HDF improves prediction, it could enable earlier identification of patients likely to develop post-STEMI remodeling and guide targeted follow-up or therapy.
Hu M, Yue X, Chen Y et al. · Magnetic resonance imaging · (2026) · View on PubMed ↗
Machine Learning / Computational Imaging & Radiomics
CardioSynergyNet: A Closed-Loop Multi-Task Deep Learning Architecture for Cardiac Segmentation and Biomarkers with Diagnosis from Paired ED-ES Cine-MRI.
This study proposed CardioSynergyNet, a closed-loop multi-task deep learning architecture for paired end-diastolic (ED) and end-systolic (ES) cine-MRI that jointly performs cardiac segmentation, biomarker extraction, and diagnosis. Using a weight-shared encoder and modules including Cross-Phase Deformation Attention (CPDA) and a Differentiable Biomarker Extraction Layer (DBEL), the model targets eight clinical biomarkers derived from segmentation while maintaining accuracy across tasks. A unified network could streamline cardiac MRI workflows by producing segmentation-derived biomarkers and diagnostic outputs in a single model.
Alqahtani S · Tomography (Ann Arbor, Mich.) · (2026) · View on PubMed ↗ · Free PDF ↗
Cardiac Magnetic Resonance Radiomics for Diagnosis, Phenotyping and Risk Stratification of Cardiomyopathies.
This systematic review evaluated evidence for cardiac magnetic resonance (CMR) radiomics in cardiomyopathies, focusing on diagnosis, phenotyping, and risk stratification. It summarized how radiomics extracts quantitative imaging features from routine CMR sequences to potentially outperform conventional visual assessment and standard CMR biomarkers. The review supports radiomics as a promising, image-derived computational approach for more precise cardiomyopathy characterization and prognosis, while highlighting the need for further validation.
Granitto C, Hoxha K, Forasassi G et al. · Healthcare (Basel, Switzerland) · (2026) · View on PubMed ↗ · Free PDF ↗
Pulmonary Vascular Disease (CTEPH/CPTE severity and risk)
Geometric morphological parameters from cardiac magnetic resonance imaging in assessment of chronic pulmonary thromboembolism, a prospective pilot study.
This prospective pilot study evaluated geometric-morphological cardiac magnetic resonance (CMR) parameters—biventricular fractal dimension (FD) and perimeter-area ratio (PAR)—in 53 patients with chronic pulmonary thromboembolism (16 with chronic thromboembolic pulmonary disease [CTEPD] and 37 with chronic thromboembolic pulmonary hypertension [CTEPH]) and 53 matched healthy controls. FD and PAR were quantified on short-axis cine images at end-diastole and end-systole across basal, mid, and apical levels, and were compared between groups to assess and stratify CPTE severity. If validated, these CMR-derived geometric biomarkers could improve noninvasive risk stratification of CPTE beyond conventional imaging and hemodynamics.
Du J, Guo Y, Yu H et al. · European radiology experimental · (2026) · View on PubMed ↗ · Free PDF ↗
Generated automatically on September 27, 2026. Covers PubMed articles published September 20, 2026 – September 27, 2026. Summaries are AI-generated; always consult the original publication for clinical or research decisions.