What's New in Cardiac MRI? — October 18, 2026
AI-summarised digest of 61 PubMed articles on Cardiac MRI published in the last 7 days.
Jump to category
What’s New in Cardiac MRI?
October 18, 2026 · 61 articles · 15 research themes · covering October 11, 2026 – October 18, 2026
Overview
Across this week’s set, cardiovascular imaging—especially CMR—continues to expand from diagnosis into prognosis, risk stratification, and even treatment decision-making. Multiple studies used CMR-derived biomarkers (e.g., myocardial entropy from T1 mapping in pulmonary arterial hypertension, ECV and LGE patterns in valvular disease, and deformation/feature-tracking measures in early cardiomyopathy phenotypes) to refine who is at greatest risk for adverse outcomes. Importantly, several works also emphasize that “how you measure” matters: guideline thresholds and imaging techniques (such as cusp-to-cusp measurement methods in aortic root assessment, or standardization issues in 4D flow CMR) can shift clinical categorization, underscoring the need for harmonization and technique-aware interpretation.
A second dominant theme is mechanism-driven care in heart failure and related systemic conditions. Real-world optimization of guideline-directed medical therapy before device decisions in HFrEF, phenotype-targeted testing of SGLT2 inhibition in HFpEF without fibrosis, and endocrine modulation (cortisol lowering in MACS) all reflect a move toward tailoring interventions to underlying biology rather than relying on single clinical labels. Complementing this, studies linking cardiac dysfunction to broader disease burden—such as regional fat distribution predicting mortality beyond BMI, epicardial adipose tissue index predicting HFpEF outcomes, and LV strain correlating with cerebral small vessel disease—highlight the growing recognition that cardiovascular risk is often multi-organ and metabolically mediated.
Finally, the digest includes a strong representation of “clinical edge cases” where imaging and careful reasoning are pivotal: rare tumor- or thrombus-mimic scenarios, immune-mediated myocarditis after infections or systemic disease, and cardiotoxicity from cancer therapy. Alongside these, engineering and AI contributions (from artifact prediction and sparse-slice reconstruction to multimodal ECG–CMR transformers) point to a future where imaging workflows are faster, more robust, and more decision-supportive—potentially improving both accuracy and access.
Suicide and Post-Incarceration Mortality
Coronary artery imaging in Kawasaki disease: recent updates in imaging techniques and clinical indications.
This review studied current and emerging imaging approaches for coronary artery assessment in Kawasaki disease across acute and chronic stages. The key finding is that echocardiography remains first-line throughout disease stages, while computed tomography angiography (CTA) and magnetic resonance imaging (MRI) provide important complementary roles, with recent CTA technical advances improving diagnostic accuracy for coronary artery lesions. This is significant because it guides clinicians on modality selection to detect coronary involvement early and monitor progression or complications.
Patharateeranart K, Goo HW, Kotoku A et al. · The international journal of cardiovascular imaging · (2026) · View on PubMed ↗
Sociodemographic, Criminological and Clinical Determinants in Suicide After Release From Prison: A 23-Year National Cohort Study.
This national cohort study used linked Norwegian registry data (Norwegian Prison Release Study, 2000–2022) to examine suicide deaths among people released from prison in Norway and to compare their suicide mortality with the general population over time. The key finding was that suicide risk remains markedly elevated after prison release, with identifiable temporal patterns and sociodemographic, criminological, and clinical determinants associated with suicide mortality. These results provide population-level evidence to target post-release suicide prevention and to refine risk stratification for individuals transitioning from prison to the community.
Bukten A, Mehlum L, Fazel S et al. · Acta psychiatrica Scandinavica · (2026) · View on PubMed ↗ · Free PDF ↗
Heart Failure Pharmacotherapy and Phenotype-Specific Trials
Dapagliflozin in phenotypically stratified HFpEF without myocardial fibrosis: the STADIA-HFpEF randomized crossover trial.
This randomized, double-blind, placebo-controlled crossover trial studied whether dapagliflozin improves left ventricular (LV) distensibility in phenotypically stratified HFpEF patients without significant myocardial fibrosis. Dapagliflozin was tested over a 34-week protocol to target mechanisms of HFpEF related to titin-based cardiomyocyte stiffness and extracellular matrix remodeling, with the trial designed to determine benefit specifically in the “no fibrosis” phenotype. Scientifically, it evaluates whether SGLT2 inhibition can improve cardiomyocyte distensibility independent of myocardial fibrosis, which could refine HFpEF treatment stratification.
Scheffer M, van Maarschalkerwaart W, Dong C et al. · European heart journal. Cardiovascular pharmacotherapy · (2026) · View on PubMed ↗ · Free PDF ↗
Effects of testosterone on exercise capacity in postmenopausal women with stage B heart failure.
This single-center, double-blind, randomized, placebo-controlled crossover trial studied whether transdermal testosterone improves exercise capacity in women aged ≥55 years with stage B heart failure. Participants received testosterone 5 mg/day versus placebo for 4 months, with enrollment restricted to those with reduced exercise capacity (below 100% age-predicted peak V˙O2peak). The clinical significance is that it tests a potential anabolic/vascular intervention for early HF-related functional limitation in postmenopausal women.
Grant J, Alexander SE, Marwick TH et al. · Climacteric : the journal of the International Menopause Society · (2026) · View on PubMed ↗ · Free PDF ↗
Left ventricular ejection fraction recovery under contemporary quadruple guideline-directed therapy and the need for ICD/CRT-D implantation in HFrEF: a retrospective single-center cohort study.
This retrospective single-center cohort study evaluated 65 patients with heart failure with reduced ejection fraction (HFrEF) in Germany who received contemporary quadruple guideline-directed medical therapy (beta-blocker, angiotensin receptor–neprilysin inhibitor, mineralocorticoid receptor antagonist, and SGLT2 inhibitor) and underwent reassessment of left ventricular ejection fraction (LVEF) to determine need for primary-prevention ICD or CRT-D. The study found that LVEF recovery under quadruple therapy was common and that reassessment after at least ~3 months could identify patients in whom ICD/CRT-D implantation might be deferred, addressing real-world gaps in guideline implementation. These findings support a strategy of optimizing modern HFrEF pharmacotherapy before device decisions to reduce potentially unnecessary ICD/CRT-D implantation while maintaining guideline-consistent risk management.
Ajmi I, Frings MP, Forkmann M et al. · Expert review of cardiovascular therapy · (2026) · View on PubMed ↗ · Free PDF ↗
Cardiac Imaging Biomarkers (CMR/ECV/T1/T2/Entropy/Fibrosis)
Cirrhotic cardiomyopathy: A comprehensive review of pathophysiology, diagnosis, and management.
This narrative review studied the pathophysiology, diagnosis, and management of cirrhotic cardiomyopathy (CCM) in the context of liver cirrhosis, including implications for liver transplantation. It reported that CCM prevalence varies widely (29% to 67.2%) depending on diagnostic criteria and emphasized impaired contractile reserve, diastolic dysfunction, and electrophysiological abnormalities, with advanced imaging and biomarkers discussed across diagnostic approaches. The review is significant because it consolidates current evidence to improve recognition and management of a frequently underdiagnosed cause of peri-transplant and long-term cardiac risk.
Zhang L, Yi J · Medicine · (2026) · View on PubMed ↗ · Free PDF ↗
Diffuse elevations of T1 and T2 are common in newly transplanted pediatric cardiac grafts without rejection and decrease over time.
This prospective CMR study evaluated 14 pediatric heart transplant recipients without acute rejection who underwent 22 non-contrast 1.5T CMR scans alongside routine catheterization, comparing new grafts (≤6 months) with established grafts (≥12 months) and matched controls. Diffuse elevations of T1 and T2 parametric maps were common in newly transplanted grafts without rejection and decreased over time. These results are important scientifically and clinically because they help distinguish normal post-transplant myocardial evolution from rejection-related CMR changes using T1/T2 mapping.
Vegulla RV, Blackwell S, Ceneri NM et al. · Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · (2026) · View on PubMed ↗ · Free PDF ↗
Septal thickness to QRS voltage ratio in Lead I/aVR: A simple tool for estimating cardiac amyloid burden.
This study assessed whether an echocardiographic-electrocardiographic (echo-ECG) index—maximum septal thickness (MST) divided by QRS voltage in lead I and/or aVR—correlates with cardiac amyloid burden quantified by CMR-derived extracellular volume (ECV). The MST/QRS voltage ratio showed a significant relationship with CMR ECV, supporting its use as a simple surrogate for amyloid burden when ECV is unavailable. This provides a widely accessible tool to improve risk stratification in patients with suspected or confirmed cardiac amyloidosis.
Sclafani M, Arcari L, Tini G et al. · International journal of cardiology · (2026) · 1 citations · View on PubMed ↗ · Free PDF ↗
Rotating Frame Spin-Lock Cardiac MRI Method at 9.4 T Can Characterize Diffuse Fibrosis in Progressing Hypertensive Heart Disease in Mice.
This preclinical mouse study tested whether rotating frame spin-lock continuous wave (CW) T1ρ and RAFF2 methods at 9.4T can characterize diffuse fibrosis in progressing hypertensive heart disease (HHD) with diastolic dysfunction. In mice with angiotensin II–induced HHD (28 days) versus sham controls, CW-T1ρ/RAFF2 measures tracked diffuse fibrosis progression and were compared against native T1 and late gadolinium enhancement (LGE). The approach could enable more sensitive, quantitative detection of diffuse myocardial fibrosis beyond conventional T1/LGE in hypertensive remodeling.
Kiviluoto R, Törmä D, Tawfek A et al. · Magnetic resonance in medicine · (2026) · View on PubMed ↗ · Free PDF ↗
Development and Prospective Validation of an Interpretable Machine Learning Model Integrating Cardiac MRI Extracellular Volume for 1-Year MACE Prediction Post-STEMI.
This work developed and prospectively validated an interpretable machine learning model in patients with ST-segment elevation myocardial infarction (STEMI) after percutaneous coronary intervention (PCI) to predict 1-year MACE using clinical variables plus CMR-derived extracellular volume (ECV). Incorporating ECV improved prediction performance, and the model’s feature selection (via Boruta) highlighted ECV-related parameters as key contributors to risk. Clinically, this provides a more transparent, CMR-informed approach to forecasting 1-year post-STEMI MACE and may help tailor follow-up and preventive strategies.
Zhao Z, Zhang Z, Yang Y et al. · Academic radiology · (2026) · View on PubMed ↗
Recurrent Nonischemic Left Ventricular Aneurysms: A Cardiac MRI-Driven Diagnosis in a DES Variant Carrier.
This case report studied recurrent nonischemic left ventricular (LV) aneurysms in a 24-year-old man who was a disease-variant carrier, using cardiac magnetic resonance (CMR) to drive diagnosis and localization. Initial CMR identified an apical LV true aneurysm with normal coronary arteries and successful surgical treatment, but five years later CMR detected a new inferolateral basal aneurysm in a previously normal region after recurrent ventricular tachycardia. The report highlights CMR’s value for detecting evolving myocardial structural disease and guiding management in nonischemic aneurysm syndromes.
Garcia NP, Forti D, Tassine Penatti LA et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗
BHSMS: a new software for searching the most stable structure of clusters based on the improved basin hopping algorithm.
This methods paper studied the development of BHSMS, a new software package for searching the most stable (global-minimum) structures of atomic and molecular clusters. The key finding is that BHSMS integrates an improved basin-hopping algorithm with structure relaxation, structure similarity recognition, planarity recognition, and molecular rotation constraints to efficiently locate stable cluster structures. Scientifically, it provides a reusable computational tool to accelerate global-minimum searches that underpin structure–property studies in cluster science.
Zhang YY, Cheng Y, Zhang SW et al. · Physical chemistry chemical physics : PCCP · (2026) · View on PubMed ↗
The Prognostic Value of Entropy from T1 Mapping in Pulmonary Arterial Hypertension.
This prospective study assessed prognostic value of myocardial entropy derived from T1 mapping on CMR in patients with pulmonary arterial hypertension (PAH), enrolling individuals who underwent CMR within 72 hours of right heart catheterization (RHC). The key finding was that higher or lower LV T1-mapping entropy (along with related T1/ECV metrics) was associated with the primary endpoint of all-cause mortality or lung transplantation, with survival analyses supporting its prognostic discrimination. Clinically, entropy-based CMR biomarkers could improve risk stratification in PAH beyond conventional hemodynamic measures.
Zhao J, Guo J, He J et al. · Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · (2026) · View on PubMed ↗ · Free PDF ↗
Quantitative assessment of myocardial dysfunction in mild focal left ventricular hypertrophy using CMR feature tracking.
This retrospective study investigated myocardial and left atrial dysfunction in patients with mild focal left ventricular hypertrophy (MF-LVH) by using CMR feature tracking (CMR-FT) to derive LV and LA deformation parameters. The key finding was that MF-LVH patients showed measurable impairment in strain-based indices compared with healthy controls and differed from HCM patients without late gadolinium enhancement (HCM-non-LGE), with diagnostic performance supported by multivariable modeling and ROC analyses. Scientifically, CMR-FT may provide a quantitative way to detect early dysfunction in MF-LVH, potentially refining phenotyping and risk assessment.
Wang X, Yao Y, Yang W et al. · Cardiology · (2026) · View on PubMed ↗
Cardiac Imaging Methods, Reconstruction, and Workflow Optimization
Machine Learning and Post-Hoc Feature Attribution for Predicting Cardiac MRI Motion Artifacts: A Retrospective Cohort Study.
This retrospective cohort study investigated machine learning models to predict the occurrence of cardiac MRI motion artifacts in 514 adult patients undergoing non-sedated CMR. Using 15 baseline clinical features that combined psychological and physiological indicators, an eXtreme Gradient Boosting model achieved the best discrimination (AUC 0.875) for artifact prediction. Clinically, this enables targeted mitigation strategies (e.g., workflow or patient preparation) to reduce rescans and improve CMR efficiency and image quality.
Li Y, Cai Q, Li L et al. · Journal of visualized experiments : JoVE · (2026) · View on PubMed ↗
Latent Interpolation Learning Using Diffusion Models for Cardiac Volume Reconstruction.
This engineering study proposed the Cardiac Latent Interpolation Diffusion (CaLID) framework to reconstruct 3D cardiac volumes from sparsely acquired 2D short-axis CMR slices without relying on predefined interpolation rules or extra semantic inputs such as segmentation labels or motion data. The key finding was that diffusion-model-based latent interpolation improves cardiac volume reconstruction under sparse sampling conditions compared with conventional interpolation approaches. This is significant for clinical CMR workflows because it can enable more complete volumetric assessment from fewer acquired slices, potentially reducing scan time and improving diagnostic utility.
Bubeck N, Shit S, Chen C et al. · IEEE transactions on medical imaging · (2026) · 1 citations · View on PubMed ↗ · Free PDF ↗
3D magnetic nanocomposite modified with molybdenum disulfide: preparation and application in aqueous Cr(vi) remediation.
This environmental materials study developed a 3D molybdenum disulfide magnetic biochar nanocomposite (3DMMB) using traditional Chinese medicine residues as biomass feedstock and iron-based sludge as an iron source, then tested it for aqueous hexavalent chromium [Cr(VI)] remediation. Solution pH significantly influenced Cr(VI) removal, and the engineered 3DMMB showed effective adsorption performance for Cr(VI) under tested conditions. The work supports a low-cost, high-efficiency adsorbent strategy for treating Cr(VI)-contaminated wastewater using industrial/agricultural waste inputs.
Duan X, Zhang J, Wang Y et al. · Nanoscale advances · (2026) · View on PubMed ↗ · Free PDF ↗
Multimodality Imaging of a Massive Intrapericardial Mediastinal Hemangioma: A Diagnostic Challenge.
This case report evaluated a 68-year-old man with a massive intrapericardial mediastinal hemangioma who had a severe iodinated contrast allergy. An iodine-free multimodality strategy using 2′-deoxy-2′-[F-18] fluoro-D-glucose positron emission tomography/computed tomography, cardiac magnetic resonance, and contrast-enhanced ultrasound—guided by 3-dimensional reconstruction—enabled safe complete surgical resection. The clinical significance is that when iodinated contrast is contraindicated, an iodine-free imaging framework can still support accurate diagnosis and operative planning.
Weng J, Han J, Mao Y et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗
Concentric macular rings: ultrawide-field biomarker in pediatric albinism.
This retrospective study evaluated the prevalence and clinical relevance of concentric macular rings (CMR sign) on ultrawide-field (UWF) imaging as a noninvasive marker of foveal hypoplasia (FH) in pediatric albinism, using UWF green-filter/red-filter imaging and OCT when feasible. The key finding was that the CMR sign on UWF imaging correlated with FH severity and could be assessed even when OCT acquisition is limited by nystagmus and poor fixation. Clinically, this supports UWF CMR sign as a practical biomarker for assessing foveal development in children with albinism, potentially reducing reliance on difficult OCT measurements.
Caminal-Caramés M, Català Mora J, Díaz-Cascajosa J et al. · Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus · (2026) · View on PubMed ↗
A Milestone in the Globalization of Cardiovascular Magnetic Resonance and a Legacy for Brazil and Latin America.
This article studied the role of SCMR Rio 2026 as a milestone in the globalization of cardiovascular magnetic resonance (CMR) and its impact on Brazil and Latin America’s scientific capacity. The key finding is that the meeting catalyzed regional development through international participation, Latin American leadership, education, certification, and multidisciplinary collaboration to expand access to high-quality CMR. This is significant for the scientific community because it documents a model for building sustainable regional expertise in advanced cardiac imaging.
Rochitte CE, Azevedo C, Fernandes JL · Arquivos brasileiros de cardiologia · (2026) · View on PubMed ↗ · Free PDF ↗
Machine Learning and AI for Cardiovascular Imaging/Diagnosis
HeartFusion: A Cross-Modality Transformer for Accurate Cardiovascular Disease Diagnosis and Severity Assessment.
This JoVE study developed and evaluated HeartFusion, a cross-modality transformer that studied ECG and cardiac MRI integration for cardiovascular disease diagnosis and severity assessment. The method encoded wavelet-derived ECG time-frequency representations and MRI structure (via Cardioformer and TransUNet, respectively) and aligned modality embeddings using cosine-similarity-based cross-modal attention, then used a transformer classifier with an ordinal regression head for severity prediction. The approach is significant because it provides a reproducible framework for combining electrophysiology and anatomy to improve diagnostic accuracy and ordered severity estimation in cardiovascular disease.
Ji Y, Hu Y · Journal of visualized experiments : JoVE · (2026) · View on PubMed ↗
AI and Deep Learning in Cardiovascular Imaging: From Risk Stratification to Precision Phenotyping.
This review article summarized how artificial intelligence (AI) and deep learning are being applied to cardiovascular imaging, spanning tasks from risk stratification to precision phenotyping across modalities such as chest radiography and computed tomography. The key finding was that modern AI methods can extract quantitative imaging features that correlate with prognosis and clinical phenotypes beyond conventional interpretation. This is significant because it frames current capabilities and limitations of AI in cardiovascular imaging, guiding translation toward more personalized diagnosis and management.
Diao K, Lu J, Dimitrakakis A et al. · Arteriosclerosis, thrombosis, and vascular biology · (2026) · View on PubMed ↗
Echocardiography–CMR Integration and Guideline Harmonization
Optimizing Echocardiographic Evaluation of Chronic Mitral Regurgitation: Comparison With Cardiac Magnetic Resonance Imaging and Implications for Guideline Recommendations.
This prospective study compared American Society of Echocardiography (ASE) criteria for definite severe chronic mitral regurgitation (MR) against quantitative cardiac magnetic resonance (CMR) in 177 patients undergoing near-simultaneous transthoracic echocardiography and CMR. The key finding was the performance/optimization of ASE native MR guideline criteria when fewer than four criteria are present, using CMR as the reference standard. This is significant for guideline-based echocardiographic decision-making, potentially improving MR severity classification and downstream management when full criterion sets are not met.
El-Tallawi KC, Angulo C, Chamsi-Pasha M et al. · JACC. Cardiovascular imaging · (2026) · View on PubMed ↗
Divergent aortic root cusp-to-cusp measurement techniques on CMR: geometric implications and threshold reclassification.
This retrospective study evaluated discrepancies between ESC and EACTS guideline approaches for aortic root cusp-to-cusp measurements on non-contrast 3D CMR in 50 relatively young patients (mean age 42 years). It found that the widest-to-widest cusp-to-cusp measurement systematically produced higher values than the middle cusp-to-cusp method, leading to meaningful reclassification of thresholds relevant to prophylactic aortic root replacement risk stratification. The work highlights that measurement technique choice can change clinical categorization, implying that guideline thresholds may need harmonization or technique-specific interpretation.
Zelis JM, van Dijk A, Duijnhouwer TD et al. · European heart journal. Imaging methods and practice · (2026) · View on PubMed ↗
Coronary Disease Assessment in Special Populations (e.g., Kawasaki, Microvascular)
Fully quantitative CMR rest perfusion reveals myocardial perfusion abnormality in Kawasaki disease: Association with left ventricular Remodeling.
This prospective single-center study evaluated 87 children with Kawasaki disease using fully quantitative CMR rest perfusion to measure myocardial blood flow (MBF) corrected for heart rate–blood pressure product (MBFcor), and analyzed associations with left ventricular (LV) remodeling. Patients with Kawasaki disease demonstrated myocardial perfusion abnormalities on quantitative rest perfusion CMR, and these abnormalities were associated with subsequent LV remodeling. The results support quantitative CMR perfusion as a noninvasive marker of myocardial injury risk in pediatric Kawasaki disease.
Zhou Z, Ye P, Wang C et al. · International journal of cardiology · (2026) · View on PubMed ↗
Papillary fibroelastoma of the coumadin ridge as an unusual cause of recurrent ischemic stroke: a case report.
This case report studied a 51-year-old woman with recurrent ischemic stroke and palpitations to identify an unusual embolic source. Multimodal imaging with transesophageal echocardiography (TEE) and cardiac magnetic resonance imaging (CMR) revealed a highly mobile pedunculated papillary fibroelastoma (PFE) attached to the coumadin ridge near the left atrial appendage ostium. The report is clinically significant because it underscores that rare benign cardiac tumors can cause recurrent stroke and that comprehensive imaging is crucial when standard thrombophilia workups are negative.
Suchodolski A, Ogrodzka A, Kemona-Kałwa R et al. · The international journal of cardiovascular imaging · (2026) · View on PubMed ↗
Cardiac Tumors and Thromboembolism Mimics
Rapid Progression of Cardiac Allograft Vasculopathy With Sudden Cardiac Death Within the First Year of Heart Transplantation: A Case Report.
This case report studied rapid progression of cardiac allograft vasculopathy (CAV) leading to sudden cardiac death in a 56-year-old man with non-ischemic cardiomyopathy after orthotopic heart transplantation. Five months post-transplant, he developed atypical chest discomfort and then sudden cardiac death within the first year, illustrating that denervation can blunt anginal warning symptoms and make SCD the first presentation of CAV. Clinically, it underscores the need for vigilant early CAV surveillance and risk assessment soon after heart transplant, even when symptoms are atypical or absent.
Dix M, Iskandar JP, He L et al. · Transplantation proceedings · (2026) · View on PubMed ↗
Real-time assessment of mitotic rate in malignant melanoma by ex vivo confocal microscopy.
This pilot study assessed whether ex vivo confocal laser scanning microscopy (EVCM) can reliably measure mitotic rate in malignant melanoma tissue to support prognostic assessment and sentinel lymph node decision-making. The key finding was the feasibility of using real-time EVCM on fresh tissue to estimate mitotic activity, aligning with the prognostic role of mitotic rate. This is significant because it suggests a rapid intraoperative imaging approach that could improve early melanoma staging without waiting for conventional histopathology.
Hartmann D, Wex K, Braun A et al. · Clinical and experimental dermatology · (2026) · View on PubMed ↗
Abdominal Pain as the First Presentation of Severe Heart Failure With Reduced Ejection Fraction and Left Ventricular Thrombus in a Young Asymptomatic Patient: A Diagnostic Interception.
This clinical case report described a young, asymptomatic, physically active patient who presented with abdominal pain and was incidentally found to have severe heart failure with reduced ejection fraction (HFrEF) and a left ventricular apical thrombus. Early cardiac evaluation led to appropriate management and complete thrombus resolution. The case highlights abdominal pain as a potential atypical first presentation of severe HFrEF with LV thrombus, emphasizing the value of prompt cardiac assessment.
Alarfaj MO, Alsuwailem BS, Aljeezan MK et al. · Clinical case reports · (2026) · View on PubMed ↗ · Free PDF ↗
PFO-Mediated Paradoxical Coronary Embolism Causing Myocardial Infarction: Concordant Imaging Findings.
This case report studied a 36-year-old man with myocardial infarction caused by paradoxical coronary embolism in the setting of a patent foramen ovale (PFO). Coronary angiography showed distal thrombotic occlusion without significant atherosclerosis, while cardiac magnetic resonance demonstrated subendocardial-to-transmural infarction with edema confined to the corresponding vascular territory and echocardiography confirmed right-to-left shunting through a PFO. The report emphasizes that concordant multimodality imaging can establish the mechanism of MI when a venous thromboembolic source is otherwise difficult to prove.
Shrestha A, Wong C, Theuerle J et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗
Intracardiac Thrombi Mimicking Cardiac Metastases in a Patient With Lung Adenocarcinoma.
This case report studied a 50-year-old man with lung adenocarcinoma and venous thromboembolism who developed intracardiac masses that persisted despite therapeutic anticoagulation. Cardiac magnetic resonance raised concern for cardiac metastases, but histopathology after excision showed organizing thrombus, and the remaining ventricular lesion resolved after 1 month of therapeutic enoxaparin. Clinically, it underscores that fibrin-rich cancer-associated thrombi can mimic metastases on CMR and that integrating imaging with pathology and anticoagulation response can prevent misdiagnosis.
Lembo M, De Vivo R, La Mura L et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗
Primary Cardiac Leiomyosarcoma in a Young Patient: A Therapeutic Challenge.
This case report studied diagnosis and treatment challenges of primary cardiac leiomyosarcoma in a 29-year-old man, using echocardiography, cardiac magnetic resonance (CMR), positron emission tomography (PET), and histopathology with immunohistochemistry. Imaging and immunohistochemical analysis confirmed primary cardiac leiomyosarcoma, and the patient remained alive at 20 months while receiving systemic therapy. The case underscores the aggressive nature and diagnostic difficulty of this rare cardiac malignancy and the lack of standardized treatment pathways.
Calzadilla-Gutierrez HR, Blanco-Adrian N, Vaca-Villarroel JM et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗
Myocarditis and Inflammatory/Immune-Mediated Cardiac Disease
Prospective Cardiac MRI study comparing Recovered COVID-19 patients with Recovered Non-COVID-19 Viral Respiratory Infection Patients (R-COVID-CMR).
This prospective longitudinal cardiovascular magnetic resonance (CMR) study compared recovered COVID-19 patients with recovered non-COVID viral respiratory infection patients to assess myocardial inflammation. By using CMR-based evaluation of myocardial involvement, it aimed to determine whether the extent and severity of subclinical inflammation differ between post-COVID and non-COVID viral illnesses. The scientific significance is that it clarifies the myocarditis/inflammation risk profile after COVID-19 relative to other viral infections, informing follow-up strategies and risk stratification.
Ho LK, Hei ST, Yan HS et al. · Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · (2026) · View on PubMed ↗ · Free PDF ↗
Loeffler’s Endomyocarditis: Clinical characteristics and outcomes from a tertiary care centre registry.
This retrospective single-center registry study characterized clinical features and outcomes of 18 patients with Loeffler’s endomyocarditis (cardiac manifestation of hypereosinophilic syndrome) diagnosed between 2017 and 2025, using biomarkers, echocardiography, CMR, and endomyocardial biopsy (n=8). Two clinical patterns were identified, including an acute inflammatory form with elevated troponin T, C-reactive protein, fever, and subepicardial late gadolinium enhancement on CMR. Recognizing these phenotypes may help clinicians anticipate disease course and tailor management for this restrictive, eosinophilic cardiomyopathy.
Buske P, Krieghoff C, Lücke C et al. · International journal of cardiology · (2026) · View on PubMed ↗ · Free PDF ↗
Fulminant Eosinophilic Myocarditis in Steroid-Refractory Hypereosinophilic Syndrome: Navigating the Thrombotic Stage With Targeted Biologic Therapy.
This case report described a 57-year-old woman with steroid-refractory hypereosinophilic syndrome who developed fulminant eosinophilic myocarditis with thromboembolic complications. Cardiac magnetic resonance (CMR) identified a large laminar thrombus and subendocardial necrosis, and targeted biologic therapy with mepolizumab (anti–interleukin-5) was initiated after relapse despite pulse-dose steroids and hydroxyurea. The report highlights the role of CMR in detecting thrombotic and necrotic myocardial involvement and supports IL-5–targeted therapy as a strategy for refractory eosinophilic myocarditis.
Althobaiti M, Aldlgan D, Alfehaid L et al. · JACC. Case reports · (2026) · 1 citations · View on PubMed ↗ · Free PDF ↗
Loeffler’s Endomyocarditis With Embolic Stroke Secondary to Chronic Eosinophilic Leukemia With Therapy-Related Molecular Features.
This case report evaluated a 77-year-old man with chronic eosinophilic leukemia with therapy-related molecular features who developed Loeffler’s endomyocarditis complicated by embolic stroke. CMR and echocardiography demonstrated a large apical left ventricular thrombus with diffuse endomyocardial involvement consistent with eosinophil-mediated disease. The clinical significance is that clonal eosinophilic disorders can present with high-risk endomyocardial thrombosis and stroke, and multimodality cardiac imaging is crucial for diagnosis and management.
Ramesh S, Yousif N, Affas Z et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗
Acute Myocarditis as an Immune-Mediated Complication of Mpox Infection.
This case report described a 32-year-old man with well-controlled HIV who developed acute myocarditis after mpox infection confirmed by polymerase chain reaction. CMR showed lateral-wall edema on T2-weighted imaging and nonischemic late gadolinium enhancement meeting the updated Lake Louise Criteria, with preserved ejection fraction and recovery with supportive care. Scientifically, it expands the spectrum of immune-mediated cardiac complications of mpox and demonstrates how CMR criteria can confirm myocarditis when ischemic causes are excluded.
Khoury F, Kim JHJ, Baghdasaryan E et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗
Apical-to-Mid-Ventricular Phenotypic Shift in Recurrent Takotsubo Syndrome After Minor Trauma.
This case report studied recurrent Takotsubo syndrome (TTS) triggered by minor trauma in an 84-year-old woman with prior apical TTS, using serial troponins, echocardiography, coronary angiography, left ventriculography, and cardiac magnetic resonance (CMR). After a ground-level fall with blunt chest trauma, she developed a mid-ventricular TTS phenotype (mid-ventricular akinesia with hyperkinetic apex) with elevated troponin and lateral T-wave inversions, while obstructive coronary disease was excluded. The findings suggest that trauma can precipitate atypical TTS phenotypic shifts, supporting the need for repeat multimodality imaging when TTS recurs.
Khoury F, Chandi M, Johal M et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗
Relapsing-Remitting Perimyocarditis and Emerging Acute Myeloid Leukemia.
This case report studied relapsing-remitting perimyocarditis as an initial presentation of acute myeloid leukemia (AML) in a 66-year-old man after Coxsackievirus B exposure, using repeat CMR and endomyocardial biopsy. Initial work-ups were unrevealing, but repeat CMR showed biventricular dysfunction with myocardial edema and new late gadolinium enhancement plus a circumferential pericardial effusion, and biopsy confirmed severe lymphocytic myocarditis. The report is clinically significant because it emphasizes that persistent or relapsing myocarditis/perimyocarditis can be an early clue to underlying AML, warranting ongoing hematologic reassessment.
Zipperer-Giblin MB, Bowman JI, Patel N et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗
Cardiac Manifestations of EGPA: An Overlap Phenotype of Inflammatory Myocardial Injury and Takotsubo-Like Syndrome.
This case report studied cardiac manifestations of eosinophilic granulomatosis with polyangiitis (EGPA) in a 42-year-old woman, focusing on an overlap between inflammatory myocardial injury and Takotsubo-like syndrome. The patient developed acute LV dysfunction with lymphocyte-predominant myocardial inflammation and Takotsubo-like features complicated by LV thrombus, with EGPA confirmed as antineutrophil cytoplasmic antibodies (ANCA)-negative based on eosinophilia, vasculitis, mononeuritis multiplex, and myocardial inflammation. The report is clinically significant because it broadens the recognized cardiac spectrum of EGPA and highlights the need to consider inflammatory myocarditis and thrombus risk when Takotsubo-like presentations occur in systemic vasculitis.
Shalit B, Buonomo G, Shaw DG et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗
Acute Pancreatitis Presenting With ST-Segment Elevation and Marked Troponin Elevation: A Diagnostic Dilemma in a Resource-Limited Setting-A Case Report.
This case report studied a patient with acute pancreatitis presenting with ST-segment elevation and marked troponin elevation, creating a diagnostic dilemma that mimicked acute coronary syndrome. The key finding is that in a resource-limited setting lacking coronary angiography, CMR, and serial high-sensitivity troponin testing, distinguishing pancreatitis-associated myocardial injury from Type 1 myocardial infarction is particularly challenging. Clinically, the report emphasizes the need for careful diagnostic reasoning and alternative evaluation strategies when advanced cardiac testing is unavailable.
Aweke SK, Assale NM, Mengistu AG et al. · Clinical case reports · (2026) · View on PubMed ↗ · Free PDF ↗
Cardio-Oncology and Treatment-Related Cardiotoxicity
FOLFOX-Associated Ventricular Fibrillation Arrest in a Patient With Colon Cancer.
This JACC Case Reports report described a 43-year-old man with stage IIIB colon cancer who developed out-of-hospital ventricular fibrillation arrest about 72 hours after the first FOLFOX cycle (leucovorin, fluorouracil [5-FU], and oxaliplatin). The key finding was fluoropyrimidine-associated cardiotoxicity presenting with severe left ventricular systolic dysfunction that improved on cardiac MRI without myocardial edema or late gadolinium enhancement. This is clinically significant because it highlights a rare but life-threatening arrhythmic complication of FOLFOX and supports the use of cardiac MRI to characterize the cardiotoxic mechanism.
Al Osta S, Ahmed M, Xu WD et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗
Congenital Heart Disease Imaging and Interventions
Septal dysfunction and Abnormal Systolic Stretch Are Associated with Right Ventricular Dysfunction in Repaired Tetralogy of Fallot.
This retrospective study examined associations between septal dysfunction, abnormal systolic stretch, and right ventricular (RV) dysfunction in 126 pediatric patients after repaired tetralogy of Fallot (rToF). Using contemporaneous ECG, echocardiography, and cardiac MRI (2019–2025), the investigators quantified septal mechanics via strain-derived systolic measures and tested whether septal dysfunction relates to electro-mechanical dyssynchrony (EMD)-induced RV dysfunction. The findings are clinically important because they suggest septal mechanics and systolic stretch abnormalities may help identify rToF patients at risk for RV dysfunction and adverse outcomes.
Fournier E, Joye R, Bitterman Y et al. · Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography · (2026) · View on PubMed ↗
Cardiovascular Magnetic Resonance Predictors of Residual Pulmonary Regurgitation and Biventricular Recovery After Pulsta Valve Implantation.
This retrospective pediatric cardiology study investigated CMR predictors of residual pulmonary regurgitation (PR), residual right ventricular enlargement (RVE), and residual biventricular imbalance (BVI) after Pulsta self-expanding percutaneous pulmonary valve implantation (PPVI). In 98 patients with paired pre- and post-procedural CMR, the authors evaluated how CMR-derived right ventricular outflow tract anatomy and baseline metrics relate to post-procedure outcomes in a setting where PR and pulmonary stenosis can be mixed. The clinical significance is that it may improve patient selection and procedural planning beyond RV volume thresholds alone used for conventional pulmonary valve replacement.
Baek SM, Ahn C, Lee SY et al. · Pediatric cardiology · (2026) · View on PubMed ↗
Prenatal Diagnosis of Distal Aortopulmonary Window by Fetal Cardiac MRI.
This JACC Case Reports article studied prenatal diagnosis of a distal aortopulmonary window using fetal cardiac MRI in a fetus with suboptimal great-vessel visualization on ultrasound. Fetal MRI demonstrated the characteristic “heart-shaped” appearance of the great vessels consistent with a distal aortopulmonary window. The significance is that fetal cardiac MRI can provide complementary anatomical detail when echocardiography is limited, improving characterization of complex fetal outflow tract abnormalities.
Verley M, Anquetil S, Ferreira LN et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗
4D Flow Acquisition Parameters as Technical Correlates of Hemodynamic Measurements: An Analysis of the multicenter Tetralogy of Fallot Registry of 4D flow Energetics and Kinetics (TREK).
This multicenter observational analysis used data from the Tetralogy of Fallot 4D flow Registry of Energetics and Kinetics (TREK) to evaluate how 4D flow CMR acquisition parameters (including magnet vendor, sequence, and signal quality) correlate with hemodynamic measurements in repaired tetralogy of Fallot (rTOF). The study found that technical acquisition factors meaningfully influence derived 4D flow biomarkers such as kinetic energy, vorticity, and viscous energy loss. This is important for standardizing 4D flow CMR protocols and improving comparability of hemodynamic biomarkers across sites and scanners.
Loke YH, Lee M, O’Hara R et al. · Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · (2026) · View on PubMed ↗ · Free PDF ↗
Guiding Pacemaker Implantation With Multimodality Imaging in an Adult With Ventricular Septal Defect.
This case report studied a 57-year-old adult with congenital ventricular septal defect and complex anatomy who required pacemaker implantation for complete heart block. Multimodality imaging was used preprocedurally to map septal and conduction-relevant anatomy and guide optimal lead positioning, improving procedural safety and reducing technical difficulty. The report highlights the scientific and clinical value of advanced imaging planning in adult congenital heart disease to optimize device implantation.
Singh AK, Eastwood C, Wong C · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗
Right Ventricular Function Assessed by Speckle Tracking Echocardiography in Patients Undergoing Transcatheter Pulmonary Valve Replacement.
This prospective study assessed right ventricular (RV) function changes after transcatheter pulmonary valve replacement (TPVR) in 50 pediatric patients using speckle tracking echocardiography (STE) at pre-op, post-operative day 1, and 6-month follow-up. The key finding was that STE-derived RV systolic strain (including RV free-wall longitudinal strain and RV four-chamber strain) and right atrial strain parameters changed after TPVR, indicating measurable improvements/alterations in RV mechanics. Scientifically and clinically, it supports STE as a feasible alternative to CMR for longitudinal monitoring of RV systolic function after TPVR.
Kucuk M, de Alba CG, Zablah J et al. · Pediatric cardiology · (2026) · View on PubMed ↗
Establishing the reliability of non-contrast 4D flow in congenital heart disease at 1.5T.
This prospective cohort study evaluated the reliability of non-contrast 4D flow cardiac MRI at 1.5T in pediatric and young adult patients with congenital heart disease (CHD), comparing non-contrast 4D flow (NC 4D Flow) against 2D phase-contrast (2D PC) flow and ventricular stroke volumes. The key finding was that NC 4D flow correlated well with 2D PC measurements and showed acceptable agreement on Bland–Altman analysis. This is significant because it supports NC 4D flow as a practical, less burdensome method for quantifying flow and stroke volume in CHD without contrast administration.
Brown NK, Romberg EK, Schmitt C et al. · Pediatric radiology · (2026) · View on PubMed ↗ · Free PDF ↗
Valvular Heart Disease Risk Stratification (AR/MR/AS/TAVI)
Coronary microvascular dysfunction in patients undergoing transcatheter aortic valve implantation: A systematic review and meta-analysis.
This systematic review and meta-analysis synthesized evidence on coronary microvascular dysfunction (CMD) in patients with severe aortic stenosis undergoing transcatheter aortic valve implantation (TAVI), focusing on pooled CMD prevalence, changes in coronary flow reserve (CFR) and microvascular resistance, and prognostic impact on major adverse cardiovascular events (MACE). The key finding was the pooled prevalence of post-TAVI CMD and how baseline CMD relates to subsequent MACE, with effects influenced by the diagnostic modality used across studies. This is clinically significant because it clarifies how often CMD occurs after TAVI and whether it can serve as a prognostic marker to refine risk stratification.
Panyawongkhanti M, Chintrakulchai P, Tanking C et al. · PloS one · (2026) · View on PubMed ↗ · Free PDF ↗
Impact of the Extent, Pattern, and Location of Replacement Myocardial Fibrosis on Clinical Outcomes in Aortic Regurgitation.
This study evaluated, in consecutive patients with moderate-to-severe chronic aortic regurgitation (AR) undergoing contrast-enhanced cardiac magnetic resonance (CMR), how the extent, pattern, and location of late gadolinium enhancement (LGE) replacement myocardial fibrosis relate to major adverse cardiovascular events (MACE). Greater LGE-detected replacement fibrosis burden and specific spatial patterns were associated with worse clinical outcomes, including cardiovascular mortality, heart transplantation, and heart-failure rehospitalization. These findings support using LGE characterization on CMR to risk-stratify AR patients by identifying myocardial replacement fibrosis as a prognostic marker.
Li B, Dai L, Liu Y et al. · European heart journal. Cardiovascular Imaging · (2026) · View on PubMed ↗
Cardiac Arrhythmias and Electrophysiology Risk
The Innocent Delta Wave in Progressive Cardiomyopathy - Culprit vs Bystander.
This case report described a 34-year-old man with progressive cardiomyopathy and recurrent palpitations who had a short PR interval after cardioversion, in the context of hypertrophic cardiomyopathy (HCM) phenotype and family history of HCM with conduction disease. The key finding was that the patient’s ECG “delta wave” pattern was interpreted as a culprit versus bystander phenomenon in the setting of progressive cardiomyopathy. This is clinically significant because it emphasizes careful ECG interpretation in HCM/conduction disease to determine whether pre-excitation is driving symptoms or reflecting an associated finding.
Ansari AG, Shanmugam S, Vijay J et al. · The American journal of cardiology · (2026) · View on PubMed ↗
LGL-Phenocopy With Dual AV Nodal Physiology and Malignant SVT: A Diagnostic Pitfall With Sudden Deaths.
This case report evaluated a 45-year-old man with malignant supraventricular tachycardia (SVT) whose presentation mimicked Lown-Ganong-Levine (LGL) phenocopy due to dual atrioventricular nodal physiology. ECG during symptoms showed SVT with Hisian extrasystole and QRS variability, and postconversion ECG demonstrated short PR with dual AV nodal physiology in a patient with a family history of sudden cardiac death. The significance is that “benign” LGL-phenocopy patterns can conceal malignant substrates, so careful electrophysiologic assessment is warranted to prevent sudden death.
Negm AY, Zhfan S, Khalil M et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗
Compound MYH7 Mutations: Risk Stratification Challenges in an Affected Family.
This case report studied genotype-positive hypertrophic cardiomyopathy (HCM) risk stratification in a 54-year-old man from a family with borderline phenotypic expression, using genetic testing for MYH7 variants. The patient carried only the MYH7 Ala655Thr pathogenic variant (while his daughter had two pathogenic MYH7 variants, Ala655Thr and Gly571Arg) and was asymptomatic with mild septal hypertrophy and nonsustained ventricular tachycardia. The report highlights that MYH7 mutation burden and variant combinations can complicate sudden cardiac death (SCD) risk stratification in genotype-positive relatives with subtle phenotypes.
Hammad A, Yeung A, Goldschmidt H et al. · JACC. Case reports · (2026) · View on PubMed ↗ · Free PDF ↗
Cardiometabolic and Systemic Risk Links (e.g., fat distribution, brain CSVD)
Left ventricular myocardial strain impairment correlates with cerebral small vessel disease burden in patients with normal ejection fraction.
This cross-sectional study enrolled 139 participants with preserved left ventricular ejection fraction who underwent concurrent cardiac and brain MRI to test whether left ventricular myocardial strain impairment correlates with cerebral small vessel disease (CSVD) burden. The key finding was that impaired left ventricular strain measures were associated with greater CSVD burden on neuroimaging despite normal ejection fraction. This is significant because it links subclinical cardiac dysfunction to cerebral microvascular injury, suggesting strain imaging may help identify patients at risk for CSVD-related brain changes.
Wang W, Zhang X, Liang M et al. · Brain research bulletin · (2026) · View on PubMed ↗ · Free PDF ↗
Clinical phenotype and outcomes of low-risk HCM patients who maintained stable exercise habits during follow-up.
This study evaluated clinical phenotype and follow-up outcomes in 253 low-risk patients with hypertrophic cardiomyopathy (HCM) stratified by reliably documented, stable exercise habits (sedentary, mild, or vigorous activity). Patients who maintained stable regular exercise showed a more favorable clinical phenotype and better follow-up outcomes than sedentary counterparts within the low-risk HCM group. These findings suggest that sustained exercise participation may identify a subgroup of low-risk HCM patients with improved prognostic profile, informing risk stratification and lifestyle counseling.
Pelliccia A, Ferrera A, Daniello CD et al. · International journal of cardiology · (2026) · View on PubMed ↗
Association of Cardiac MRI-Derived Epicardial Adipose Tissue Index With Adverse Clinical Outcomes in Heart Failure With Preserved Ejection Fraction.
This retrospective study assessed 265 patients with heart failure with preserved ejection fraction (HFpEF) and quantified the cardiac MRI-derived epicardial adipose tissue index (EATI) on 1.5T cine images. Higher EATI was associated with increased risk of major adverse cardiovascular events (MACE), including cardiac death and HF-related readmission. These findings suggest EATI could serve as an imaging biomarker for prognosis in HFpEF.
Ma S, Qian L, Lou K et al. · Journal of magnetic resonance imaging : JMRI · (2026) · 1 citations · View on PubMed ↗ · Free PDF ↗
Regional fat distribution as a determinant of mortality in populations with left ventricular systolic dysfunction: challenging the obesity paradox.
This study analyzed whether regional fat distribution predicts mortality in individuals with left ventricular systolic dysfunction, using UK Biobank Imaging Enhancement Programme participants who underwent cardiac magnetic resonance (CMR). Among CMR-defined left ventricular systolic impairment (LVEF <50%), specific adiposity phenotypes based on regional fat distribution were associated with mortality, challenging the “obesity paradox” suggested by BMI alone. Scientifically and clinically, the results indicate that metabolically adverse fat distribution may better stratify risk than BMI in patients with impaired systolic function.
Khanna S, Ho W, Takeuchi F et al. · European journal of preventive cardiology · (2026) · 9 citations · View on PubMed ↗
Endocrine/Metabolic Disorders Affecting the Heart (e.g., cortisol, diabetes)
Cardiovascular effects of metyrapone treatment in patients with mild autonomous cortisol secretion: a secondary analysis.
This secondary analysis studied 15 patients with mild autonomous cortisol secretion (MACS) (12 women; mean age 59 years) to assess cardiovascular effects of cortisol lowering with evening metyrapone (500 mg at 6 pm and 250 mg at 10 pm) over 12 weeks. After treatment, the study evaluated changes in blood pressure regulation, cardiac fat depots, cardiac morphology and myocardial function, and other cardiovascular risk factors. These findings are clinically relevant because they test whether metyrapone-mediated cortisol reduction can improve cardiovascular risk in MACS, a condition linked to increased cardiovascular mortality.
Niziolek H, Just I, Baumgartner C et al. · The Journal of clinical endocrinology and metabolism · (2026) · 2 citations · View on PubMed ↗ · Free PDF ↗
Left ventricular end-diastolic pressure in women with ischemia and no obstructive coronary artery disease: The women’s ischemia syndrome evaluation - Coronary microvascular dysfunction study (WISE-CVD).
This study investigated women with ischemia and no obstructive coronary artery disease (INOCA; n=253) using invasive coronary functional testing to measure resting left ventricular end-diastolic pressure (LVEDP) and coronary microvascular dysfunction, with a predefined subset undergoing cardiac MRI (CMR). Coronary microvascular dysfunction was associated with impaired LV relaxation and elevated LVEDP, supporting a mechanistic link between CMD and higher filling pressures. Clinically, this provides invasive/CMR-relevant evidence that CMD-mediated diastolic impairment may contribute to HFpEF physiology in INOCA women.
Ranasinghe S, Tjoe B, Chang J et al. · International journal of cardiology · (2026) · 1 citations · View on PubMed ↗ · Free PDF ↗
Pattern and texton-based feature descriptors for diabetic foot ulcer detection.
This paper studied a deep learning framework for diabetic foot ulcer (DFU) detection, named DLS-DFUD, using image preprocessing, segmentation, feature extraction, and classification. The key finding is that the proposed pipeline uses wavelet transform-based Wiener filtering (WT-WF) for noise reduction and improves DFU detection performance compared with conventional approaches (as reported in the study’s experiments). Clinically, a more accurate and prompt DFU detection system could help reduce infection and amputation risk by enabling earlier intervention in people with diabetes.
Mastanvali, Rajini NH, Laxmaiah M · Expert review of medical devices · (2026) · View on PubMed ↗
Generated automatically on October 18, 2026. Covers PubMed articles published October 11, 2026 – October 18, 2026. Summaries are AI-generated; always consult the original publication for clinical or research decisions.