PubMed Trending Research Digest — May 10, 2026

A curated digest of 97 trending PubMed articles, automatically categorised and summarised across 15 research areas.

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Psychiatric risk prediction & treatment algorithms Reproductive biology & germ cell development Metabolic health, diabetes & diet–microbiome–bile acid axes Neurotechnology & neuromodulation Cancer immunotherapy biomarkers & resistance mechanisms Cancer genomics, multi-omics & biomarker signatures Tumor microenvironment, stromal interactions & fibrosis Targeted therapies & drug mechanisms (oncology) Gene therapy & oligonucleotide therapeutics Neurodegeneration & cognitive disorders Cardiovascular screening, risk prediction & procedural care Renal disease & proteinuria/immune kidney therapies Infectious disease, sepsis & immune regulation Bone, muscle & aging interventions Environmental health & toxicology (incl. microplastics/air exposures)

Automated digest · 97 articles · 15 research areas · May 10, 2026

Overview

Across this week’s set of papers, a dominant theme is “actionability” through biomarkers, risk scores, and mechanism-linked targeting. Multiple studies use omics- and data-driven approaches to stratify patients or predict outcomes—e.g., proteomics-based aging clocks for healthspan prediction, plasma protein risk scoring for diabetic CKD, blood-based CD8+ T-cell phenotypes to forecast checkpoint inhibitor response in NSCLC, and radiomics-derived intratumoral heterogeneity phenotypes in HCC. In oncology, several mechanistic works connect specific molecular pathways to therapy resistance or vulnerability (e.g., TAM metabolic control via SLC2A1, endothelial sensing of TMZ resistance to drive macrophage infiltration, and ferroptosis/radioresistance regulation by IFI16), reinforcing a shift from “one-size-fits-all” toward pathway- and microenvironment-informed treatment selection.

A second major theme is modulation of disease via targeted interventions—ranging from drugs and biologics to device- and cell-based strategies. Gene/oligonucleotide therapeutics appear repeatedly (AAV anti-VEGF for nAMD; antisense oligonucleotides such as tofersen in SOD1 ALS; and broader AOC/oligonucleotide conjugate platforms), while neuromodulation and neurotechnology progress through focused ultrasound for pain and BBB-penetrant PARP inhibition for intracranial malignancies, plus implantable high-density neural recording arrays. In immune-mediated and inflammatory diseases, microbiome and immune-axis studies (e.g., Akkermansia in severe acute pancreatitis; gut–liver acetaldehyde clearance; and platelet NLRP6 in sepsis) highlight how specific host pathways can be targeted to rebalance harmful inflammation.

Finally, several papers emphasize prevention and risk reduction by addressing modifiable exposures and health determinants. Diet and microbiota interventions (oat β-glucan for glucose homeostasis; low-carbohydrate vs Mediterranean patterns in T2DM) and environmental/toxicology work (microplastics/additives driving aquatic toxicity; PET microplastics implicated in IPF pathways; second-hand smoke and lung cancer risk) converge on the idea that measurable exposures can be mechanistically linked to downstream disease. Complementing this, clinical and guideline-focused articles (e.g., sepsis core-measure bundles, AF-CARE frameworks, and metformin prevention of antipsychotic-induced weight gain) show how evidence synthesis is being translated into standardized care pathways.

Psychiatric risk prediction & treatment algorithms

Modifiable risk factors and risk of schizophrenia and bipolar disorder across severities of genetic risk.

This UK Biobank study examined whether the brain care score (BCS)—a 12-factor modifiable risk tool—predicts incident schizophrenia (SCZ) or bipolar disorder (BD) risk across strata of genetic risk measured by polygenic risk scores (PRS). Higher BCS was associated with lower SCZ/BD risk, with effects varying by PRS-defined genetic liability (gene–environment interaction/stratified analyses). These findings support targeting modifiable brain-health factors to reduce psychiatric risk even among individuals with high genetic predisposition.

Cui Y, Sun Y, Liu S et al. · Journal of affective disorders · (2026) · View on PubMed ↗

The global prevalence of eating disorders in children and young people: a systematic review and meta-analysis.

This systematic review and meta-analysis estimated the global prevalence of eating disorders in children and young people by pooling population-level studies published between January 2013 and February 27, 2024. It reported a worldwide pooled prevalence of eating disorders across CYP, with heterogeneity assessed using I2 and study quality evaluated with the Hoy scale (numerical results truncated in the abstract). Quantifying global prevalence improves public health planning and highlights the scale of ED burden in youth populations.

Faria C, Daneshi K, Baser A et al. · European child & adolescent psychiatry · (2026) · View on PubMed ↗

INTEGRATE: international guidelines for the algorithmic treatment of schizophrenia.

The INTEGRATE project synthesized international evidence to produce an algorithmic, pharmacology-focused guideline for schizophrenia treatment, developed through an umbrella review, expert workshops, a consensus survey, and lived-experience focus groups. The key output was a consensus algorithmic treatment framework and associated digital tool intended to standardize decision-making across regions. This is significant because it addresses the lack of concise, comprehensive, internationally applicable algorithmic guidance for schizophrenia pharmacotherapy.

McCutcheon RA, Pillinger T, Varvari I et al. · The lancet. Psychiatry · (2025) · View on PubMed ↗

Metformin for the Prevention of Antipsychotic-Induced Weight Gain: Guideline Development and Consensus Validation.

This study developed and validated a clinical guideline for using metformin to prevent antipsychotic-induced weight gain (AIWG) in people with severe mental illness (SMI). The key finding was that a metformin-focused guideline was produced using AGREE II methods and then consensus-validated as an evidence-to-practice framework for AIWG prevention. Clinically, it supports standardized metformin use to reduce AIWG risk in SMI populations receiving antipsychotics.

Carolan A, Hynes-Ryan C, Agarwal SM et al. · Schizophrenia bulletin · (2025) · View on PubMed ↗

This systematic review examined how organizational culture influences work-related stress among nurses across healthcare settings. The key finding was that organizational culture factors are consistently associated with nurses’ work-related stress, with the review identifying culture-related determinants as under-researched but important drivers. Scientifically and operationally, it highlights organizational culture as a modifiable target for interventions to improve nurse well-being and potentially patient care quality.

Kiptulon EK, Elmadani M, Limungi GM et al. · BMC health services research · (2024) · View on PubMed ↗

Correlation between ethical sensitivity and humanistic care ability among undergraduate nursing students: a cross-sectional study.

This cross-sectional study assessed the relationship between ethical sensitivity and humanistic care ability among 656 undergraduate nursing students using validated questionnaires. The key finding was a positive correlation between total ethical sensitivity scores and total humanistic care ability scores (r=0.426, P<0.0 as reported in the abstract). This suggests that strengthening ethical sensitivity training may improve humanistic care competencies in nursing education.

Zhang Y, Li S, Huang Y et al. · BMC nursing · (2024) · View on PubMed ↗

This fMRI study investigated how feelings of love recruit brain reward and social cognition circuits in humans when the love target was a romantic partner, one’s children, friends, strangers, pets, or nature. Neural activity patterns differed by love object, indicating that “love” is not a single uniform neural state but depends on the specific social or non-social target. These findings refine mechanistic models of pair-bonding and attachment and may guide future neurobiological studies of relationship-specific disorders.

Rinne P, Lahnakoski JM, Saarimäki H et al. · Cerebral cortex (New York, N.Y. : 1991) · (2024) · View on PubMed ↗

Evaluating Monitoring Guidelines of Clozapine-Induced Adverse Effects: a Systematic Review.

This systematic review evaluated the content and quality of existing monitoring guidelines for clozapine-induced adverse effects in patients with treatment-resistant schizophrenia. It found that many monitoring guidelines/recommendations may be incomplete, lacking one or more important monitoring elements across metabolic, neuroendocrine, cardiovascular, and gastrointestinal risks. The clinical significance is that identifying gaps can support more comprehensive monitoring standards to reduce serious clozapine toxicity while preserving its unique efficacy.

Smessaert S, Detraux J, Desplenter F et al. · CNS drugs · (2024) · View on PubMed ↗

Reproductive biology & germ cell development

Male germ cell-specific deletion of Eif5 causes the apoptosis of mouse progenitor spermatogonia by excessive endoplasmic reticulum stress and defective DNA repair.

This mouse study used a Stra8-Cre–driven conditional knockout of Eif5 (Eif5 fl/fl × Stra8-Cre) to test how loss of eukaryotic translation initiation factor 5 (eIF5) affects spermatogonial survival and DNA repair. Male germ cell–specific Eif5 deletion caused apoptosis of progenitor spermatogonia, driven by excessive endoplasmic reticulum (ER) stress and defective DNA repair, alongside reduced SOX3+ progenitor spermatogonia and impaired KIT signaling. The results identify eIF5 as a mechanistic regulator of germ cell maintenance and a potential molecular target for idiopathic non-obstructive azoospermia (iNOA).

Wei H, Huang Y, Wang W et al. · Zoological research · (2026) · View on PubMed ↗

PGC-derived migrasomes couple PGC proliferation with migration.

This zebrafish study investigated how primordial germ cells (PGCs) coordinate proliferation with migration using migrasomes, vesicular organelles formed during movement. Migrasomes were generated via tspan7-dependent biogenesis at retraction fibers and delivered the growth factor GDF3 to neighboring PGCs through contact-dependent interactions, activating the TGF-β receptor acvr1ba to drive proliferation. The work reveals a mechanism that stabilizes mitogenic signaling within migrating cells, supporting germline expansion during embryogenesis.

Liu B, Jiang Z, Song W et al. · Nature communications · (2026) · View on PubMed ↗

R-loops orchestrate RNAPII transcriptional reprogramming for the maternal-to-zygotic transition.

This study investigated how R-loops regulate RNA polymerase II (RNAPII) transcriptional reprogramming during the maternal-to-zygotic transition in mammalian preimplantation embryos. It found that CG-density-dependent R-loop dynamics are required for proper MZT, and that loss of CG-poor R-loops causes defects by promoting premature activation of major zygotic genome activation (ZGA) genes. These results define a mechanistic role for R-loops in early embryonic gene regulation and developmental timing.

Li Y, Li Q, Wang X et al. · Cell research · (2026) · View on PubMed ↗

Intermittent fasting boosts sexual behavior by limiting the central availability of tryptophan and serotonin.

This study tested whether intermittent fasting (IF) alters aging-related male reproductive decline in C57BL/6J mice by limiting central availability of tryptophan and serotonin, thereby affecting serotonergic inhibition of mating behavior. IF preserved reproductive success in aged males primarily by improving mating behavior rather than sperm quality or endocrine measures, and the mechanism involved reduced tryptophan supply leading to lower serotonergic inhibition. The findings are significant because they connect a dietary intervention to a defined neurochemical pathway that modulates reproductive behavior during aging.

Xie K, Wang C, Scifo E et al. · Cell metabolism · (2025) · View on PubMed ↗

The modeling of human implantation and early placentation: achievements and perspectives.

This review assessed achievements and future directions for modeling human implantation and early placentation, summarizing the strengths and limitations of in vivo, ex vivo, and in vitro approaches. The key finding is that peri-implantation maternal–fetal crosstalk is difficult to study directly in humans, so model choice critically affects what biological processes can be inferred. Scientifically, it guides researchers in selecting and interpreting implantation models to better support potential clinical interventions despite ethical constraints.

Dimova T, Alexandrova M, Vangelov I et al. · Human reproduction update · (2025) · View on PubMed ↗

Polycystic ovary syndrome.

This Nature Reviews Disease Primers article reviewed the epidemiology, diagnosis, and emerging evidence for polycystic ovary syndrome (PCOS) in women (and discusses possible relevance to men’s health). It highlights that adult PCOS diagnosis uses the International Evidence-based Guideline requiring two of three features (clinical/biochemical hyperandrogenism, ovulatory dysfunction, and/or ovarian morphology or elevated anti-Müllerian hormone), while adolescent diagnosis omits ovarian morphology and anti-Müllerian hormone. The clinical significance is that age-specific diagnostic criteria are essential to avoid misclassification and to guide earlier, more targeted management of insulin resistance and hyperandrogenism in adolescents and adults.

Stener-Victorin E, Teede H, Norman RJ et al. · Nature reviews. Disease primers · (2024) · View on PubMed ↗

Clinical Relevance of Vaginal and Endometrial Microbiome Investigation in Women with Repeated Implantation Failure and Recurrent Pregnancy Loss.

This review studied the clinical relevance of vaginal and endometrial microbiome assessment in women with repeated implantation failure (RIF) and recurrent pregnancy loss (RPL). It found that Lactobacillus dominance is generally associated with reproductive tract eubiosis and better implantation outcomes, whereas vaginal/endometrial dysbiosis may promote local inflammation and pro-inflammatory cytokines that impair endometrial receptivity. The scientific significance is that microbiome profiling could become a biomarker-driven approach to improve embryo implantation and pregnancy outcomes in RIF/RPL populations.

Gao X, Louwers YV, Laven JSE et al. · International journal of molecular sciences · (2024) · View on PubMed ↗

Metabolic health, diabetes & diet–microbiome–bile acid axes

Oat β-glucan reshapes gut microbiota to enhance glucose homeostasis via coordinated modulation of bile acid conjugation and succinate-dependent intestinal gluconeogenesis.

This preclinical study tested whether oat β-glucan improves glucose homeostasis in obese mice by reshaping gut microbiota and altering bile acid conjugation and intestinal gluconeogenesis. Oat β-glucan improved glucose intolerance and insulin resistance, increased GLP-1 secretion, enriched specific taxa (e.g., Faecalibaculum, Muribaculaceae, Bifidobacterium, Akkermansia), and increased secondary bile acids (lithocholic acid and deoxycholic acid) while coordinating succinate-dependent intestinal gluconeogenesis. These data suggest oat β-glucan can act through microbiota–bile acid–metabolic pathways to ameliorate type 2 diabetes physiology.

Meng Y, Li S, Zhou K et al. · Food chemistry · (2026) · View on PubMed ↗

Comparative Evaluation of a Low-Carbohydrate Diet and a Mediterranean Diet in Overweight/Obese Patients with Type 2 Diabetes Mellitus: A 16-Week Intervention Study.

This 16-week intervention study compared a low-carbohydrate diet (LCD; <130 g/day) versus a Mediterranean diet in overweight/obese adults with type 2 diabetes mellitus (T2DM). The key finding (as the study’s comparative aim) was the differential impact of these two dietary patterns on metabolic outcomes relevant to T2DM and weight management over the intervention period. Clinically, it informs dietary selection by testing whether carbohydrate restriction provides advantages over Mediterranean-style nutrition for glycemic control and cardiometabolic risk in T2DM.

Currenti W, Losavio F, Quiete S et al. · Nutrients · (2023) · View on PubMed ↗

Neurotechnology & neuromodulation

Large-scale single-neuron recording in the human cortex using an ultra-flexible electrode array.

This human translational study evaluated an ultra-flexible implantable neural electrode array (uFINE) for large-scale single-neuron recordings during intraoperative procedures in patients. The uFINE array enabled reliable, high-density single-unit recordings while maintaining mechanical integrity throughout surgery. This advances clinical neurotechnology by improving feasibility of high-resolution cortical recording for research and potential future diagnostic/therapeutic applications.

Wu S, Yan Z, Kong C et al. · Nature communications · (2026) · View on PubMed ↗

Catalytic neural stem cell exosomes for multi-stage targeting and synergistical therapy of retinal ischemia-reperfusion injury.

This study developed a neural stem cell exosome engineered with polylysine (K10) decoration and catalase expression (CataKNexo) to target retinal ischemia-reperfusion injury (RIRI), using in vitro retinal models and focusing on oxidative stress localized to the outer nuclear layer (ONL). The key finding was that CataKNexo reaches the ONL and provides synergistic antioxidant and neuroprotective effects by counteracting hydrogen peroxide (H2O2)-mediated oxidative damage. This is significant because it provides a targeted, enzyme-delivering exosome strategy that could improve treatment of retinal ischemia-reperfusion injury.

Yang W, Wang X, Zheng D et al. · Cell reports. Medicine · (2025) · View on PubMed ↗

Low-intensity transcranial focused ultrasound suppresses pain by modulating pain-processing brain circuits.

This preclinical study used low-intensity transcranial focused ultrasound (tFUS) with a custom 128-element mouse transducer to modulate pain-processing brain circuits and suppress pain behaviors in vivo. The key finding was that targeted tFUS stimulation of pain-related circuits significantly altered pain-associated behaviors after a single session. These results support focused ultrasound as a nonpharmacologic neuromodulation strategy for chronic pain with potential to reduce reliance on opioids.

Kim MG, Yu K, Yeh CY et al. · Blood · (2024) · View on PubMed ↗

Preclinical Characterization of AZD9574, a Blood-Brain Barrier Penetrant Inhibitor of PARP1.

This preclinical study evaluated AZD9574, a blood-brain barrier–penetrant selective PARP1 inhibitor, using in vitro assays of PARylation inhibition and PARP-DNA trapping and in vivo mouse xenograft models (subcutaneous and intracranial), with BBB penetration assessed in mouse, rat, and monkey. AZD9574 showed BBB crossing and PARP1-target engagement with antitumor activity, and it was tested for efficacy and safety as monotherapy and in combination with temozolomide (TMZ). These findings support AZD9574 as a candidate brain-penetrant PARP1 inhibitor for treating intracranial malignancies, potentially in combination with TMZ.

Staniszewska AD, Pilger D, Gill SJ et al. · Clinical cancer research : an official journal of the American Association for Cancer Research · (2024) · View on PubMed ↗

Transcutaneous Electrical Stimulation for Neurogenic Bladder After Spinal Cord Injury: A Systematic Review and Meta-Analysis.

This systematic review and meta-analysis studied transcutaneous electrical nerve stimulation (TENS) for neurogenic bladder after spinal cord injury (SCI), focusing on randomized controlled trials. Across 11 trials (881 participants), meta-analysis evaluated effects on primary outcomes including maximum cystometric capacity (MCC) and residual urine volume (RUV), along with secondary urodynamic and diary measures. The findings are clinically significant because they quantify the efficacy of a noninvasive neuromodulation approach for improving bladder function in SCI patients.

Jiang Y, Li X, Guo S et al. · Neuromodulation : journal of the International Neuromodulation Society · (2024) · View on PubMed ↗

Cancer immunotherapy biomarkers & resistance mechanisms

Phenotype of circulating tumor-reactive T cells predicts immune checkpoint inhibitor response in non-small cell lung cancer.

This study analyzed paired tumor-infiltrating and circulating CD8+ tumor-reactive T cells in patients with non-small cell lung cancer using single-cell RNA sequencing and T cell receptor (TCR) sequencing. It found that the phenotype of circulating tumor-reactive T cells—marked by specific surface markers such as CD49a, CD49b, and HLA-DR—predicts response to immune checkpoint inhibitors. This provides a potential blood-based biomarker strategy to stratify NSCLC patients for ICI therapy.

Ito K, Iida K, Hirano T et al. · Nature communications · (2026) · View on PubMed ↗

SLC2A1+ tumour-associated macrophages spatially control CD8+ T cell function and drive resistance to immunotherapy in non-small-cell lung cancer.

This study examined how SLC2A1+ tumor-associated macrophages (TAMs) spatially regulate CD8+ T cell function and contribute to resistance to immunotherapy in non-small cell lung cancer. It found that SLC2A1 expression in tumors is spatially negatively correlated with CD8+ T cell distribution in human biopsies and mouse models, and that TAM-specific Slc2a1 deletion improves intratumoral CD8+ effector function and enhances αPD-L1 efficacy. This identifies SLC2A1 in TAMs as a spatial immune-modulatory target to overcome checkpoint blockade resistance.

Wang L, Chu H, Chen D et al. · Nature cell biology · (2026) · View on PubMed ↗

The immune microenvironment of colorectal cancer.

This review summarized how the colorectal cancer (CRC) tumor microenvironment (TME) governs immune evasion and therapy response, emphasizing why only a subset of patients benefits from immune checkpoint blockade (ICB). The key finding was that immune-activated, microsatellite unstable CRC responds to ICB, whereas the predominant microsatellite-stable tumors remain poorly immunogenic and immunosuppressed, limiting benefit. Strategies that reprogram the CRC TME to convert “cold” tumors into immune-activated states are therefore central to improving immunotherapy outcomes.

Kennel KB, Greten FR · Nature reviews. Cancer · (2025) · View on PubMed ↗

Autophagy in cancer development, immune evasion, and drug resistance.

This review article synthesized evidence on how macroautophagy/autophagy contributes to cancer development, immune evasion, and drug resistance, emphasizing context-dependent roles. The key finding was that autophagy can switch from tumor-suppressive effects in early stages to pro-tumor functions during later carcinogenesis, influenced by genetic and environmental factors. Scientifically, it frames autophagy as a mechanistic pathway that may be therapeutically targeted to overcome immune evasion and anticancer drug resistance.

Niu X, You Q, Hou K et al. · Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy · (2025) · View on PubMed ↗

Disrupting B and T-cell collaboration in autoimmune disease: T-cell engagers versus CAR T-cell therapy?

This 2024 immunology review compared strategies that disrupt B and T-cell collaboration in autoimmune disease, focusing on T-cell engagers versus CAR T-cell therapy and how these approaches relate to B-cell depletion (BCD) outcomes. The key finding is that targeting B–T interactions can yield variable effects on B-cell depletion, whereas many patients benefit from anti-CD20–mediated BCD, highlighting differences in mechanism and likely clinical impact. Scientifically, it frames how next-generation T-cell–directed therapies may complement or differ from established B-cell–targeting regimens in refractory autoimmune disease.

Shah K, Leandro M, Cragg M et al. · Clinical and experimental immunology · (2024) · View on PubMed ↗

Biomarker-directed targeted therapy plus durvalumab in advanced non-small-cell lung cancer: a phase 2 umbrella trial.

This phase 2 umbrella trial evaluated biomarker-directed targeted therapy combined with durvalumab (anti–PD-L1) in advanced non-small-cell lung cancer (NSCLC) patients whose tumors lacked currently targetable molecular alterations. The key finding is that the study framework targets known resistance mechanisms to immune checkpoint blockade—such as DNA damage response/repair defects, STK11/LKB1 alterations, antigen-presentation pathway changes, and immunosuppressive tumor microenvironment features—by matching therapies to biomarkers while using durvalumab as the immunotherapy backbone. Scientifically, it aims to overcome resistance to anti–PD-(L)1 therapy and improve durability of benefit in a population without standard actionable driver mutations.

Besse B, Pons-Tostivint E, Park K et al. · Nature medicine · (2024) · View on PubMed ↗

Cancer genomics, multi-omics & biomarker signatures

Multi-omics and machine learning reveal DPPC as a key contributor to colorectal cancer progression and tumor immune microenvironment remodeling.

This study used integrated multi-omics, two-sample Mendelian randomization, single-cell transcriptomics, and machine learning to identify metabolic drivers of colorectal cancer progression and immune microenvironment remodeling. It reported that DPPC (a phosphatidylcholine metabolite) is a key contributor to CRC progression and tumor immune microenvironment changes, supported by experimental validation (specific experimental details truncated in the abstract). The work suggests DPPC as a potential biomarker and therapeutic entry point linking lipid metabolism to anti-tumor immunity in CRC.

Li X, Dong H, Jin Z et al. · Journal of translational medicine · (2026) · View on PubMed ↗

RNA m1A methyltransferase TRMT61A promotes colorectal tumorigenesis by enhancing ONECUT2 mRNA stability and is a potential therapeutic target.

This study investigated the RNA m1A methyltransferase TRMT61A in colorectal cancer (CRC) to determine whether it promotes tumorigenesis by regulating ONECUT2 mRNA stability. The key finding was that TRMT61A increases ONECUT2 mRNA stability, thereby enhancing CRC growth, and that TRMT61A is a clinically relevant therapeutic target supported by mechanistic analyses using m1A-seq/RNA-seq plus CRC cell lines, patient-derived organoids, xenografts, and transgenic mouse models. Therapeutically inhibiting TRMT61A—potentially via nanoparticle-based small interfering RNA (siRNA)—could suppress CRC progression driven by the TRMT61A–ONECUT2 axis.

Zhang X, Qin N, Ji F et al. · Cancer communications (London, England) · (2025) · View on PubMed ↗

Mapping early human blood cell differentiation using single-cell proteomics and transcriptomics.

This study mapped early human blood cell differentiation using single-cell proteomics by mass spectrometry (scp-MS) integrated with single-cell RNA sequencing (scRNA-seq) in >2500 human CD34+ hematopoietic stem and progenitor cells. The authors identified proteins important for stem cell function that were not indicated by mRNA transcripts, demonstrating that proteomics adds differentiation-relevant biology beyond scRNA-seq alone. This improves resolution of human hematopoietic lineage trajectories and can refine biomarkers and models for early blood development and related disorders.

Furtwängler B, Üresin N, Richter S et al. · Science (New York, N.Y.) · (2025) · View on PubMed ↗

Blood plasma proteome-wide association study implicates novel proteins in the pathogenesis of multiple cardiovascular diseases.

This study performed a proteome-wide association study (PWAS) to identify novel plasma proteins implicated in the pathogenesis of 26 cardiovascular diseases using UK Biobank Pharma Proteomics Project data from 53,022 individuals. By integrating SNP–protein weights with GWAS summary statistics, the authors reported protein associations across cardiac, venous, and cerebrovascular disease categories, highlighting new candidate proteins for CVD biology. These results provide a proteomics-informed route to prioritize therapeutic targets and biomarkers beyond traditional GWAS.

Wang JH, Dong SS, Huang W et al. · Cardiovascular diabetology · (2025) · View on PubMed ↗

HER2DX and survival outcomes in early-stage HER2-positive breast cancer: an individual patient-level meta-analysis.

This individual patient-level meta-analysis studied whether the HER2DX genomic test risk score predicts survival outcomes in early-stage HER2-positive breast cancer. The key finding was that HER2DX risk stratification was associated with survival, indicating that HER2DX captures clinically relevant biological heterogeneity beyond standard clinicopathologic factors and pathologic complete response. This supports using HER2DX to improve personalized risk assessment and treatment decision-making in early HER2-positive disease.

Villacampa G, Pascual T, Tarantino P et al. · The Lancet. Oncology · (2025) · View on PubMed ↗

Cancer of the corpus uteri: A 2025 update.

This 2025 narrative update reviewed endometrial (corpus uteri) cancer across heterogeneous histopathologic subtypes, including staging, surgical and non-surgical management, follow-up, and treatment of recurrent disease. It reports that endometrial cancer incidence and mortality are both increasing and synthesizes current evidence on how these trends affect clinical decision-making. The update is clinically significant because it consolidates evolving diagnostic and therapeutic strategies for a disease with rising burden and variable outcomes.

Koskas M, Crosbie EJ, Fokdal L et al. · International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · (2025) · View on PubMed ↗

Noninvasive prognostic classification of ITH in HCC with multi-omics insights and therapeutic implications.

This multi-center study analyzed intratumoral heterogeneity (ITH) in hepatocellular carcinoma (HCC) across 851 patients using noninvasive radiomics from multi-sequence MRI to define radiomics ITH (RITH) phenotypes and then integrated multi-omics to interpret underlying mechanisms. The RITH phenotypes strongly correlated with both prognosis and pathological ITH, and multi-omics analysis clarified molecular drivers associated with the RITH groups. This is clinically significant because it provides a noninvasive, prognostic classification of HCC ITH with mechanistic interpretability that may inform therapeutic stratification.

Xie Y, Wang F, Wei J et al. · Science advances · (2025) · View on PubMed ↗

The study developed and validated a glycolysis-related gene (GRG) signature to predict prognosis and immunotherapy efficacy in breast invasive carcinoma using TCGA-BRCA as a training set and GEO as a validation cohort. The authors identified a GRG-based prognostic model that stratified patients by survival risk and was associated with differences in immunotherapy-related response. This provides a gene-expression tool to refine risk prediction and potentially guide immunotherapy selection in heterogeneous breast cancer patients.

Huang R, Li Y, Lin K et al. · Frontiers in immunology · (2025) · View on PubMed ↗

Tumor microenvironment, stromal interactions & fibrosis

Endothelial cells sense temozolomide resistance to facilitate monocyte-derived macrophage infiltration in glioblastoma.

This study investigated how temozolomide (TMZ) resistance in patient-derived glioblastoma organoids (GBOs) alters endothelial-cell signaling to promote monocyte-derived macrophage (MDM) infiltration, with a focus on mesenchymal and recurrent GBM. The key finding was that endothelial cells “sense” TMZ resistance and thereby facilitate MDM recruitment, identifying molecular drivers upregulated in TMZ-resistant recurrent GBOs as potential therapeutic targets to block this infiltration. Disrupting this endothelial–MDM recruitment axis could improve outcomes for TMZ-resistant GBM by limiting a major component of the tumor microenvironment that supports treatment failure.

Gao W, Huang J, Deng K et al. · Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy · (2026) · View on PubMed ↗

Spatial-reprogramming derived GPNMB+ macrophages interact with COL6A3+ fibroblasts to enhance vascular fibrosis in glioblastoma.

This study analyzed glioblastoma (GBM) tumor microenvironment organization using integrated single-cell and spatial transcriptomics to define how spatially reprogrammed GPNMB+ macrophages interact with COL6A3+ fibroblasts. The key finding was that these macrophage–fibroblast spatial interactions enhance vascular fibrosis in GBM, supported by validation experiments including multiplex immunohistochemistry and atomic force microscopy. Interfering with the GPNMB+ macrophage–COL6A3+ fibroblast crosstalk could represent a strategy to counter resistance to combined immune checkpoint blockade (ICB) and antiangiogenic therapy.

Du Y, Long X, Li X et al. · Genome medicine · (2025) · View on PubMed ↗

ANGPTL2+cancer-associated fibroblasts and SPP1+macrophages are metastasis accelerators of colorectal cancer.

This study examined how ANGPTL2-positive cancer-associated fibroblasts (ANGPTL2+ CAFs) and SPP1-positive macrophages (SPP1+ macrophages) drive metastasis acceleration in colorectal cancer, focusing on liver metastasis. Using bulk RNA-seq and clinicopathologic data from TCGA/GEO plus single-cell RNA-seq analyses (TISCH) and immune deconvolution, it identified these immune/stromal populations as key contributors to metastatic progression. The work is significant because it highlights ANGPTL2+ CAFs and SPP1+ macrophages as potential therapeutic targets to prevent or treat colorectal cancer liver metastasis.

Liu X, Qin J, Nie J et al. · Frontiers in immunology · (2023) · View on PubMed ↗

Targeted therapies & drug mechanisms (oncology)

This mechanistic study examined how SIRT3 regulates STEAP4 to modulate cuproptosis sensitivity in HBV-related hepatocellular carcinoma (HCC). Integrative analyses of clinical specimens and HBx-transgenic mouse models showed HBV X protein (HBx) downregulates STEAP4, and SIRT3 deacetylates STEAP4 to reprogram mitochondrial metabolism and alter susceptibility to cuproptosis. The findings connect HBV-driven metalloreductase control to regulated cell death vulnerability, suggesting potential therapeutic strategies that exploit cuproptosis in HBV-HCC.

Du ZB, Wu XM, Lei JM et al. · Cell death and differentiation · (2026) · View on PubMed ↗

Comparative effectiveness of atogepant and rimegepant for migraine prevention in Japanese patients: an anchored matching-adjusted indirect comparison.

This anchored matching-adjusted indirect comparison compared atogepant versus rimegepant for migraine prevention in Japanese patients using data from three placebo-controlled trials (RELEASE and PROGRESS for atogepant; BHV3000-309 for rimegepant). It assessed efficacy using changes in mean monthly migraine days and mean monthly acute medication use days, and evaluated quality-of-life outcomes including MSQ v2.1 RFR, MIDAS, and EQ-VAS (numerical results truncated in the abstract). The analysis informs comparative effectiveness and tolerability expectations for preventive CGRP-pathway therapies in Japan.

Takizawa T, Ahmadyar G, Tyas E et al. · Expert review of neurotherapeutics · (2026) · View on PubMed ↗

Structural basis for the recruitment and selective phosphorylation of Akt by mTORC2.

This structural biology study elucidated how mTORC2 selectively recruits and phosphorylates Akt by determining the molecular basis of substrate recognition. Using semisynthetic probes to trap the mTORC2–Akt complex, it characterized the structural determinants that enable Akt phosphorylation while explaining high specificity relative to other kinases. These findings clarify a core mechanism of PI3K/Akt pathway signaling relevant to cancer and diabetes where mTORC2 activity is dysregulated.

Taylor MS, Chen M, Hancock M et al. · Science (New York, N.Y.) · (2026) · View on PubMed ↗

Guanine nucleotides drive ribosome biogenesis and glycolytic reprogramming in acute myeloid leukemia stem cells.

This study examined venetoclax (Ven)-resistant acute myeloid leukemia (AML) stem cells (LSCs) and how they rewire metabolism and ribosome biogenesis to survive OXPHOS inhibition. The key finding was that abundant de novo guanine nucleotide biosynthesis supports glycolytic reprogramming and enhanced ribosome biogenesis, suppressing the impaired ribosome biogenesis checkpoint (IRBC) via TP53 destabilization and sustained MYC expression. Targeting guanine nucleotide metabolism or the IRBC–TP53–MYC axis may help overcome Ven resistance in AML LSCs.

Kawano G, Ikeda R, Ishihara D et al. · Blood · (2026) · View on PubMed ↗

Antibody-oligonucleotide conjugates in cancer therapy: Potential and Promise.

This review article examined antibody-oligonucleotide conjugates (AOCs) as next-generation targeted cancer therapeutics, contrasting them with antibody-drug conjugates (ADCs). It highlights that AOCs use gene-modulating oligonucleotides such as siRNA and antisense oligonucleotides (ASO) instead of cytotoxic payloads, offering a modular targeting–linker–payload design with potential advantages in mechanism and specificity. The synthesis supports continued development of AOCs as promising precision oncology platforms and frames key translational considerations for clinical progress.

Meng Q, Yang M, Xing F et al. · Critical reviews in oncology/hematology · (2025) · View on PubMed ↗

PD-1 antibody camrelizumab plus apatinib and SOX as first-line treatment in patients with AFP-producing gastric or gastro-esophageal junction adenocarcinoma (CAP 06): a multi-center, single-arm, phase 2 trial.

This multi-center, single-arm phase 2 trial studied first-line camrelizumab (PD-1 antibody) plus apatinib and S-1/oxaliplatin (SOX), followed by maintenance camrelizumab plus apatinib, in patients with AFP-producing gastric or gastro-esophageal junction adenocarcinoma (CAP 06; NCT04609176). The key finding reported in the abstract is the trial’s evaluation of antitumor activity, safety, and biomarkers for this rare, highly angiogenic and immunosuppressive subtype, with confirmed objective response rate as the primary endpoint. This is significant because it provides early clinical evidence for combining PD-1 blockade with anti-angiogenic therapy in a molecularly distinct gastric cancer subgroup.

Wang Y, Lu J, Chong X et al. · Signal transduction and targeted therapy · (2025) · View on PubMed ↗

Asciminib in Newly Diagnosed Chronic Myeloid Leukemia.

This phase 3 randomized trial studied asciminib, a BCR::ABL1 inhibitor that specifically targets the ABL myristoyl pocket, versus an investigator-selected ATP-competitive TKI in patients with newly diagnosed chronic myeloid leukemia (CML). The key finding was that asciminib achieved favorable efficacy and safety outcomes compared with standard frontline TKI therapy in this newly diagnosed population. This is significant because it offers a mechanism-distinct first-line option that may reduce side effects while maintaining disease control.

Hochhaus A, Wang J, Kim DW et al. · The New England journal of medicine · (2024) · View on PubMed ↗

Neoadjuvant FOLFIRINOX versus upfront surgery for resectable pancreatic head cancer (NORPACT-1): a multicentre, randomised, phase 2 trial.

This multicentre, randomized phase 2 trial (NORPACT-1) studied neoadjuvant FOLFIRINOX versus upfront surgery in adults with resectable pancreatic head ductal adenocarcinoma across 12 hospitals in Denmark, Finland, Norway, and Sweden. The key finding (as the trial’s primary comparison) was the relative efficacy and safety of neoadjuvant chemotherapy followed by resection versus immediate surgery, assessed in a randomized design. Scientifically, it tests whether perioperative FOLFIRINOX can improve outcomes beyond standard upfront surgery in resectable pancreatic cancer, potentially shifting neoadjuvant treatment strategies.

Labori KJ, Bratlie SO, Andersson B et al. · The lancet. Gastroenterology & hepatology · (2024) · View on PubMed ↗

TROPION-Breast02: Datopotamab deruxtecan for locally recurrent inoperable or metastatic triple-negative breast cancer.

This article describes the phase III TROPION-Breast02 clinical trial evaluating datopotamab deruxtecan (Dato-DXd), an anti–TROP2 antibody-drug conjugate linked to a topoisomerase I inhibitor payload, in patients with locally recurrent inoperable or metastatic triple-negative breast cancer (TNBC). The trial compares Dato-DXd versus investigator’s choice chemotherapy in patients previously untreated for this setting who are not candidates for PD-1/PD-L1 inhibitors. The study is significant because it tests whether TROP2-targeted ADC therapy improves efficacy and safety in a high-need TNBC population.

Dent RA, Cescon DW, Bachelot T et al. · Future oncology (London, England) · (2023) · View on PubMed ↗

Gene therapy & oligonucleotide therapeutics

This systematic review and meta-analysis evaluated whether gene therapy—primarily adeno-associated virus (AAV)-based anti-VEGF constructs—provides safe and clinically meaningful outcomes for neovascular age-related macular degeneration (nAMD) compared with baseline or standard care. The analysis focused on visual acuity, anatomical response, treatment burden, and safety, addressing the limitation of frequent anti-VEGF intravitreal injections. If benefits are confirmed, gene therapy could reduce long-term treatment burden while maintaining efficacy in nAMD.

Chen KY, Chan HC, Chan CM · American journal of ophthalmology · (2026) · View on PubMed ↗

Tofersen: A Review in Amyotrophic Lateral Sclerosis Associated with SOD1 Mutations.

This review summarized evidence for tofersen (QALSODY®) in amyotrophic lateral sclerosis (ALS) associated with SOD1 mutations, focusing on its mechanism and clinical trial outcomes. Tofersen is an intrathecally administered antisense oligonucleotide that induces SOD1 mRNA degradation and, in the phase III VALOR trial, reduced plasma neurofilament biomarkers and total SOD1 protein in cerebrospinal fluid. These findings reinforce tofersen’s target engagement and biomarker effects as a disease-modifying strategy for SOD1-mutant ALS.

McGuigan A, Blair HA · CNS drugs · (2025) · View on PubMed ↗

Tofersen for SOD1 amyotrophic lateral sclerosis: a systematic review and meta-analysis.

This systematic review and meta-analysis synthesized clinical evidence from trials, observational studies, and case reports (through October 2024) on tofersen, an antisense oligonucleotide, in adults with SOD1 mutation–associated amyotrophic lateral sclerosis (ALS). Across 12 included studies totaling 195 patients, the analysis evaluated tofersen’s safety and efficacy outcomes using random-effects meta-analysis methods in RevMan. Scientifically and clinically, it consolidates the evidence base supporting tofersen’s use in SOD1-related ALS and clarifies overall benefit–risk estimates.

Hamad AA, Alkhawaldeh IM, Nashwan AJ et al. · Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · (2025) · View on PubMed ↗

Neurodegeneration & cognitive disorders

Diagnostic accuracy of the Gold Coast Criteria for amyotrophic lateral sclerosis: a systematic review and meta-analysis.

This systematic review and meta-analysis evaluated the diagnostic accuracy of the Gold Coast Criteria (GCC) for amyotrophic lateral sclerosis (ALS) compared with the Revised El Escorial Criteria (rEEC) and Awaji Criteria (AC) in suspected ALS. The key finding was a comparative assessment of sensitivity and specificity across eligible studies using predefined inclusion rules (probable+/possible+) and quality appraisal (QUADAS-2, STARD), with sensitivity analyses addressing imputed data and study influence. Clarifying which criteria perform best supports more accurate ALS diagnosis and earlier clinical decision-making.

von Quednow E, Husain N, Łajczak P et al. · Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · (2025) · View on PubMed ↗

Comparative Efficacy and Safety of Monoclonal Antibodies for Cognitive Decline in Patients with Alzheimer’s Disease: A Systematic Review and Network Meta-Analysis.

This systematic review and network meta-analysis compared anti-amyloid beta (anti-Aβ) monoclonal antibodies for cognitive decline in patients with Alzheimer’s disease using randomized controlled trials up to March 31, 2023. It used R (v4.2.3) with JAGS and STATA to statistically rank multiple anti-Aβ mAbs by efficacy and safety, estimating odds ratios for binary outcomes and mean differences for continuous outcomes. The clinical significance is that it provides a comparative hierarchy of which anti-Aβ monoclonal antibodies may offer the best balance of cognitive benefit and adverse-event risk in early Alzheimer’s disease.

Qiao Y, Gu J, Yu M et al. · CNS drugs · (2024) · View on PubMed ↗

Cardiovascular screening, risk prediction & procedural care

Cardiac Screening for Conditions Associated With Sudden Cardiac Death: Yield, Interventions, and SCA/SCD Incidence in 104,369 Young Individuals.

This study evaluated the diagnostic yield and downstream outcomes of a one-time cardiac screening (questionnaire plus ECG) in 104,369 young individuals aged 14–35 years from the general population. The screening identified actionable cardiac conditions and enabled interventions, with subsequent SCA/SCD incidence reported after initial clearance (details truncated in the abstract). These findings support the evidence base for whether broad ECG-based screening can prevent sudden cardiac death beyond the athlete-focused setting.

MacLachlan H, Bhatia R, Raju H et al. · Journal of the American College of Cardiology · (2026) · View on PubMed ↗

Neuraxial anesthesia and pain management for cesarean delivery.

This article reviewed neuraxial anesthesia and postoperative pain management approaches for cesarean delivery, focusing on how patient and obstetrical factors influence anesthetic blockade and analgesia. The key finding was that tailoring the neuraxial technique to the clinical scenario—especially in emergency cesarean delivery—and coordinating between obstetric and anesthesia teams are crucial for safe, effective pain control. Improved selection and communication around neuraxial strategies can enhance maternal comfort and safety during and after cesarean delivery.

Landau R, Sultan P · American journal of obstetrics and gynecology · (2026) · View on PubMed ↗

Medication Adherence in Hypertension: A Cluster Randomized Clinical Trial.

This cluster randomized clinical trial studied whether a multicomponent intervention improves medication adherence in patients with uncontrolled hypertension by using linked electronic health record–pharmacy data to identify nonadherent patients and deliver team-based care. The key finding was the effectiveness of this TEAMLET (Leveraging Electronic Health Record Technology and Team Care to Address Medication Adherence) approach in addressing adherence barriers at the point of care. Clinically, it supports scalable, data-driven adherence interventions to improve hypertension control and reduce downstream cardiovascular risk.

Blecker S, Mann DM, Martinez TR et al. · JAMA cardiology · (2025) · View on PubMed ↗

Spotlight on the 2024 ESC/EACTS management of atrial fibrillation guidelines: 10 novel key aspects.

This review highlighted 10 novel aspects of the 2024 ESC/EACTS atrial fibrillation management guidelines, focusing on the AF-CARE framework and its four pillars: comorbidity/risk factor management, stroke/thromboembolism avoidance, symptom reduction via rate/rhythm control, and dynamic reassessment. The key finding is that the guideline emphasizes a structured, iterative care model (AF-CARE) to improve patient outcomes. Clinically, it provides a practical framework for implementing guideline-directed AF management in real-world care.

Rienstra M, Tzeis S, Bunting KV et al. · Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · (2024) · View on PubMed ↗

Large Language Model Influence on Diagnostic Reasoning: A Randomized Clinical Trial.

This randomized clinical trial tested whether using a large language model (LLM) improves physicians’ diagnostic reasoning compared with conventional resources. The key finding was that the trial evaluated diagnostic reasoning performance under LLM assistance versus standard tools, determining the effect of LLM use on clinician reasoning outcomes. If beneficial, this would support safer, evidence-based integration of LLMs into clinical decision support; if not, it would caution against relying on LLMs for diagnostic reasoning.

Goh E, Gallo R, Hom J et al. · JAMA network open · (2024) · View on PubMed ↗

Cardioneuroablation for the treatment of reflex syncope and functional bradyarrhythmias: A Scientific Statement of the European Heart Rhythm Association (EHRA) of the ESC, the Heart Rhythm Society (HRS), the Asia Pacific Heart Rhythm Society (APHRS) and the Latin American Heart Rhythm Society (LAHRS).

This European Heart Rhythm Association/ESC, HRS, APHRS, and LAHRS scientific statement reviewed evidence for cardioneuroablation in patients with reflex syncope and functional bradyarrhythmias such as vagally induced sinus bradycardia-arrest or atrioventricular block. The key finding is that cardioneuroablation can be an alternative to cardiac pacing in selected patients, but safe and effective use depends on proper patient selection and procedural technique. Scientifically and clinically, it provides consensus guidance to standardize practice and reduce variability in outcomes.

Aksu T, Brignole M, Calo L et al. · Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · (2024) · View on PubMed ↗

Impact of high-power short-duration atrial fibrillation ablation technique on the incidence of silent cerebral embolism: a prospective randomized controlled study.

This prospective randomized controlled study evaluated whether high-power short-duration (HPSD) atrial fibrillation ablation using the Smart Touch Surround Flow (STSF) catheter reduces silent cerebral embolism (SCE) compared with conventional ablation using the Smart Touch (ST) catheter. It randomized 100 AF patients 1:1 to HPSD-STSF versus conventional ST and assessed SCE incidence as the primary outcome. The clinical significance is that it tests whether a procedural strategy that lowers thrombus risk during ablation can reduce subclinical brain embolic events, potentially improving neurological safety of AF ablation.

Chen WJ, Gan CX, Cai YW et al. · BMC medicine · (2023) · View on PubMed ↗

Renal disease & proteinuria/immune kidney therapies

Diabetic retinal disease.

This primer reviewed diabetic retinal disease (DRD), reframing diabetic retinopathy as a whole-retina disorder affecting microvasculature plus neurons and glia. The key finding was that ongoing preclinical and clinical efforts are integrating retinal signs with visual acuity and patient-reported quality of life, alongside systemic health and biochemical milieu in people with diabetes. This broader DRD framework aims to improve understanding, classification, and future therapeutic targeting of vision loss in diabetes.

Sivaprasad S, Wong TY, Gardner TW et al. · Nature reviews. Disease primers · (2025) · View on PubMed ↗

This retrospective cohort study used US electronic health records to evaluate whether glucagon-like peptide-1 receptor agonists (GLP-1RAs) affect the risk of chronic ocular diseases, including age-related macular degeneration, in patients older than 60 years with at least 5 years of ophthalmology follow-up. After propensity matching (1:1) against comparator medication groups (metformin, insulin, statin, aspirin), the study assessed differential ocular disease incidence associated with GLP-1RA exposure. The results are clinically relevant for risk stratification of older adults receiving GLP-1RAs and for understanding potential ocular benefits or harms of these drugs.

Allan KC, Joo JH, Kim S et al. · Ophthalmology · (2025) · View on PubMed ↗

Large-Scale Proteomics Improve Prediction of Chronic Kidney Disease in People With Diabetes.

This UK Biobank cohort study developed and validated a plasma protein risk score to predict chronic kidney disease (CKD) in 2,094 people with diabetes who had no CKD at baseline, using nearly 3,000 proteins and genetic information. The key finding was that an 11-protein CKD protein risk score improved prediction of future CKD events compared with a clinical CKD Prediction Consortium model and a CKD polygenic risk score (as assessed in training and validation sets). This supports proteomics-informed risk stratification for diabetic CKD, potentially enabling earlier intervention.

Ye Z, Zhang Y, Zhang Y et al. · Diabetes care · (2024) · View on PubMed ↗

Comparative Effectiveness of Glucagon-Like Peptide-1 Receptor Agonists, Sodium-Glucose Cotransporter 2 Inhibitors, Dipeptidyl Peptidase-4 Inhibitors, and Sulfonylureas for Sight-Threatening Diabetic Retinopathy.

This retrospective observational target-trial emulation compared the risk of sight-threatening diabetic retinopathy complications among adults with type 2 diabetes initiating different glucose-lowering classes: GLP-1 receptor agonists, SGLT2 inhibitors, DPP-4 inhibitors, and sulfonylureas. The key finding was that the choice of glucose-lowering agent was associated with different risks of developing sight-threatening retinopathy outcomes over follow-up. Clinically, it suggests that diabetes medication selection may influence ocular complication risk, informing treatment decisions for patients at retinal risk.

Barkmeier AJ, Herrin J, Swarna KS et al. · Ophthalmology. Retina · (2024) · View on PubMed ↗

This phase 2b randomized, double-blind, placebo-controlled trial studied atacicept (a dual BAFF/APRIL fusion protein) in 116 biopsy-proven patients with IgA nephropathy (IgAN), comparing atacicept 150 mg, 75 mg, or 25 mg versus placebo once weekly for up to 36 weeks. The key reported finding was the change in urine protein creatinine ratio from 24-hour urine collections at weeks 24 and 36, with efficacy assessed primarily in the combined atacicept 150 mg and 75 mg groups versus placebo. Scientifically, it tests whether B-cell activation factor/APRIL blockade can reduce proteinuria and improve renal outcomes in IgAN, informing whether atacicept should proceed to later-stage development.

Lafayette R, Barbour S, Israni R et al. · Kidney international · (2024) · View on PubMed ↗

Infectious disease, sepsis & immune regulation

Efficacy and Safety of Subcutaneous Efgartigimod PH20 in Adults With Primary Immune Thrombocytopenia (ADVANCE SC): A Multicenter, Randomized, Double-Blinded, Placebo-Controlled, Phase 3 Trial.

This Phase 3 multicenter randomized double-blind placebo-controlled trial (ADVANCE SC) studied subcutaneous efgartigimod PH20 in adults with primary immune thrombocytopenia (ITP) who had platelet counts <30×10^9/L and prior ITP therapy. Subcutaneous efgartigimod PH20 produced clinically meaningful platelet responses compared with placebo, with an efficacy and safety profile consistent with the drug’s mechanism of FcRn inhibition (details truncated in the abstract). The trial supports SC efgartigimod PH20 as a potential less burdensome treatment option for chronic primary ITP.

Cooper N, Broome CM, Miyakawa Y et al. · American journal of hematology · (2026) · View on PubMed ↗

Akkermansia Muciniphila Alleviates Severe Acute Pancreatitis via Amuc1409-Ube2k-Foxp3 Axis in Regulatory T Cells.

This study examined how the gut commensal Akkermansia muciniphila modulates severe acute pancreatitis (SAP) in patients with acute pancreatitis and in Foxp3-DTR and IL-10 knockout mouse models, focusing on a regulatory T-cell axis involving Amuc1409, Ube2k, and Foxp3. It found that Akkermansia abundance is reduced in patients with acute pancreatitis and inversely correlates with systemic inflammatory severity, and that Akkermansia muciniphila ameliorates SAP through the Amuc1409–Ube2k–Foxp3/IL-10 regulatory pathway in regulatory T cells. This is scientifically and potentially clinically significant because it links a specific microbiome species to a defined T-cell molecular mechanism that could be targeted to reduce SAP-associated SIRS/CARS imbalance.

Xie J, Du L, Lu Y et al. · Advanced science (Weinheim, Baden-Wurttemberg, Germany) · (2025) · View on PubMed ↗

Platelet NLRP6 protects against microvascular thrombosis in sepsis.

This research investigated the role of nucleotide-oligomerization domain-like receptor family pyrin domain containing 6 (NLRP6) specifically in platelets during sepsis using platelet-specific NLRP6 knockout mice and the cecal ligation and puncture (CLP) model. Platelet NLRP6 deletion increased mortality and worsened microvascular thrombosis in the lung and liver. The findings are significant because they identify platelet NLRP6 as a protective regulator of sepsis-associated microvascular thrombosis and a potential therapeutic target.

Jiang H, Chen S, Gui X et al. · Blood · (2025) · View on PubMed ↗

Incidence and risk factors of ventilator-associated pneumonia in the intensive care unit: a systematic review and meta-analysis.

This systematic review and meta-analysis estimated ventilator-associated pneumonia (VAP) incidence in ICU patients and identified risk factors while assessing outcomes associated with VAP. The key finding was that pooled analyses characterized both the frequency of VAP and the factors associated with its occurrence in mechanically ventilated ICU populations. Scientifically and clinically, it helps target prevention strategies and informs risk stratification to reduce VAP-related morbidity and mortality.

Li W, Cai J, Ding L et al. · Journal of thoracic disease · (2024) · View on PubMed ↗

Berberine and magnolol exert cooperative effects on ulcerative colitis in mice by self-assembling into carrier-free nanostructures.

This preclinical mouse study investigated whether berberine (BBR) and magnolol (MAG) cooperate to treat ulcerative colitis (UC) by self-assembling into carrier-free nanostructures. The key finding was that BBR and MAG formed nanostructures in aqueous solution via charge interactions and π–π stacking and exerted cooperative anti-UC effects in mice. This suggests a novel phytochemical nanomedicine strategy that could improve UC drug delivery without conventional carriers.

Xu Y, Chen Z, Hao W et al. · Journal of nanobiotechnology · (2024) · View on PubMed ↗

Review: sepsis guidelines and core measure bundles.

This 2024 review summarized evolving sepsis screening tools and treatment protocol “core measure bundles” from major initiatives including the Surviving Sepsis Campaign, the Third International Consensus Definitions for Sepsis, and CMS measures. The key finding is that sepsis management recommendations have shifted alongside updated physiology and definitions, emphasizing prompt recognition and standardized bundle-based care. Clinically, this supports implementation of guideline-consistent pathways to improve in-hospital survival and post-discharge outcomes.

Desposito L, Bascara C · Postgraduate medicine · (2024) · View on PubMed ↗

Oral microsphere formulation of M2 macrophage-mimetic Janus nanomotor for targeted therapy of ulcerative colitis.

This study engineered an oral sodium alginate microsphere system delivering M2 macrophage membrane–coated Janus nanomotors (Motor@M2M) for targeted therapy of ulcerative colitis in vivo. The key finding was that M2 macrophage mimetic coating enhanced targeting to inflammatory tissues and acted as a decoy to neutralize inflammatory cytokines while the alginate microspheres protected the nanomotors through the gastric environment with controlled release. Scientifically, it provides a mucus- and inflammation-targeting nanomedicine approach that could improve oral UC efficacy.

Luo R, Liu J, Cheng Q et al. · Science advances · (2024) · View on PubMed ↗

Coordinated action of a gut-liver pathway drives alcohol detoxification and consumption.

This mechanistic animal study investigated a gut–liver pathway controlling alcohol detoxification and drinking by tracking acetaldehyde (AcH) clearance and voluntary alcohol consumption after ethanol intake. The key finding was that systemic AcH clearance and alcohol drinking are driven synergistically by a liver–gut axis rather than the liver alone, with liver-generated AcH excreted via the bile route. Clinically, it identifies new targets in the gut–liver detoxification network that could inform future alcohol use disorder therapies.

Fu Y, Mackowiak B, Lin YH et al. · Nature metabolism · (2024) · View on PubMed ↗

ACVIM Consensus Statement on the management of status epilepticus and cluster seizures in dogs and cats.

This ACVIM consensus statement studied the evidence base for managing seizure emergencies—status epilepticus and cluster seizures—in dogs and cats. It produced evidence-based, specialist-agreed clinical guidelines to standardize treatment approaches despite previously noted variability and lack of official guidance. The consensus is clinically significant because it can improve decision-making and potentially outcomes in veterinary patients with rapidly progressive, drug-resistant seizure emergencies.

Charalambous M, Muñana K, Patterson EE et al. · Journal of veterinary internal medicine · (2024) · View on PubMed ↗

Bone, muscle & aging interventions

Maltol induces diabetic fragility fractures by disrupting the balance of bone remodeling.

This study combined clinical metabolomics with in vivo and in vitro experiments to determine whether maltol, a widely used food additive, contributes to diabetes-associated fragility fractures. Maltol accumulation in femoral neck tissue and elevated circulating maltol correlated with higher fracture incidence, and mechanistically maltol inhibited osteoblast differentiation via Wnt/β-catenin while promoting osteoclast maturation through NF-κB signaling. These findings identify maltol as a modifiable risk factor for hyperglycemia-related skeletal fragility and suggest new targets in bone remodeling pathways.

Wang J, Wang Z, Feng J et al. · Cell metabolism · (2026) · View on PubMed ↗

Organ-specific proteomic aging clocks predict disease and longevity across diverse populations.

This study developed plasma proteomics–based organismal and organ-specific aging clocks using machine learning in UK Biobank participants (n=43,616) and validated them in independent cohorts from China (n=3,977) and the USA (n=800). It found that accelerated organ aging predicted disease onset, progression, and mortality beyond clinical and genetic risk factors, with brain aging most strongly linked to mortality, and it associated brain aging with lifestyle and genes including GABBR1 and ECM1. These proteomic aging clocks provide scalable biomarkers for predicting healthspan and longevity across diverse populations.

Wang Y, Xiao S, Liu B et al. · Nature aging · (2026) · View on PubMed ↗

Vitamin C conveys geroprotection on primate ovaries.

This study tested whether oral vitamin C can mitigate ovarian aging in primates by measuring changes in aging biomarkers and cellular “biological age” using a single-cell transcriptomic clock. The key finding was that vitamin C reduced oxidative stress and follicular depletion and decreased the transcriptomic biological age of oocytes and somatic cells, partly through activation of the NRF2 pathway. These results support vitamin C as a potential geroprotective intervention to preserve ovarian function during reproductive aging.

Jing Y, Lu H, Li J et al. · Cell stem cell · (2025) · View on PubMed ↗

Fibroblast bioelectric signaling drives hair growth.

This study examined how fibroblast bioelectric signaling regulates hair growth, using congenital generalized hypertrichosis terminalis (CGHT) genetics and mouse models. Chromatin disruption of TADs led to upregulation of the potassium channel KCNJ2 in dermal fibroblasts, and KCNJ2-driven membrane hyperpolarization enhanced dermal fibroblast Wnt signaling response to promote hair growth. The results identify KCNJ2-mediated electrical control of fibroblast signaling as a potential therapeutic axis for hair loss.

Chen D, Yu Z, Wu W et al. · Cell · (2025) · View on PubMed ↗

Alpha-Ketoisocaproate Attenuates Muscle Atrophy in Cancer Cachexia Models.

This study tested whether α-ketoisocaproate (KIC), a metabolite of L-leucine, attenuates muscle atrophy in cancer cachexia models using BALB/c mice and C2C12 myotubes exposed to C26- and 4T1-induced cachexia. KIC reduced cancer-cachexia–associated muscle wasting by targeting myostatin. These preclinical data support KIC as a candidate metabolic intervention for cancer-associated cachexia with a defined mechanism via myostatin modulation.

Lim P, Woo SW, Han J et al. · Journal of cachexia, sarcopenia and muscle · (2025) · View on PubMed ↗

hUC-MSCs and derived exosomes attenuate DEX-induced muscle atrophy through modulation of estrogen signaling pathway.

This preclinical study evaluated whether human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) and their derived exosomes (MSC-Exos) attenuate dexamethasone (DEX)-induced muscle atrophy by modulating estrogen signaling in relevant sarcopenia models. The key finding was that hUC-MSCs/MSC-Exos improved muscle outcomes and altered estrogen-pathway signaling to counter DEX-driven atrophy. This suggests an estrogen-signaling–mediated regenerative strategy using MSC-derived products for sarcopenia or steroid-associated muscle wasting.

Li N, Liu X, Wang Q et al. · Stem cell research & therapy · (2025) · View on PubMed ↗

Antiosteoporosis medication in patients with posterior spine fusion: a systematic review and meta-analysis.

This systematic review and meta-analysis compared osteoporosis medications—teriparatide, bisphosphonates, denosumab, and romosozumab—in patients with low bone mineral density undergoing posterior spine fusion. It evaluated which drug classes improve fusion outcomes and reduce complications such as pseudarthrosis and screw loosening in the perioperative setting. The clinical significance is that it aims to resolve uncertainty about optimal pharmacologic selection to improve surgical success in this high-risk population.

Jin H, Jin H, Suk KS et al. · The spine journal : official journal of the North American Spine Society · (2025) · View on PubMed ↗

Effects of intermittent pneumatic compression on delayed onset muscle soreness and recovery of muscular fatigue.

This randomized controlled trial evaluated whether intermittent pneumatic compression (IPC) affects delayed onset muscle soreness (DOMS) and recovery of muscular fatigue after plyometric exercise in 20 healthy untrained male college students. The study compared an IPC group (n=10) versus a control group (n=10) for outcomes related to DOMS and fatigue recovery following exercise-induced injury. The clinical significance is that it tests a practical recovery modality for exercise-induced muscle damage, addressing ongoing debate about IPC efficacy for DOMS prevention/treatment.

Gu Z, Dai J, Xu K et al. · PM & R : the journal of injury, function, and rehabilitation · (2025) · View on PubMed ↗

The role of nutrition in wound healing and implications for nursing practice.

This narrative review examined how specific nutrients—proteins, vitamins (A, C, E, K), and minerals (zinc, iron, copper, manganese)—affect the phases of wound healing (hemostasis, inflammation, proliferation, remodeling) and what this means for nursing practice. The key finding is that adequate nutrient availability supports collagen synthesis, immune function, and cellular activity, thereby influencing both speed and quality of recovery. Clinically, it supports nurse-led nutritional assessment and targeted dietary interventions/education as part of wound-care management.

Hill B, Mitchell A, Szydlowska A et al. · British journal of nursing (Mark Allen Publishing) · (2025) · View on PubMed ↗

Cellular senescence-associated gene IFI16 promotes HMOX1-dependent evasion of ferroptosis and radioresistance in glioblastoma.

This mechanistic study used repeated-irradiation glioblastoma multiforme (GBM) cell models and multi-omics analyses to identify how the senescence-associated gene IFI16 regulates ferroptosis and radioresistance. IFI16 promoted radioresistance by activating HMOX1 transcription, which attenuated ferroptosis after irradiation by reducing lipid peroxidation, reactive oxygen species, and intracellular Fe2+ levels. Scientifically, it links IFI16–HMOX1 signaling to ferroptosis evasion and suggests a potential target pathway to improve GBM radiotherapy responses.

Zhou Y, Zeng L, Cai L et al. · Nature communications · (2025) · View on PubMed ↗

Skeletal Muscle Stem Cells and the Microenvironment Regulation in Sarcopenia:A Review.

This review summarized current evidence on skeletal muscle stem cells (satellite cells) and how their microenvironment regulates sarcopenia, an age-related loss of skeletal muscle mass and function. The key finding is that satellite cell behavior and regenerative capacity are tightly controlled by microenvironmental signals, which change during aging and contribute to sarcopenia progression. This frames potential therapeutic strategies that target the muscle stem cell niche to preserve or restore muscle function in older adults.

Gao T, Zhang Y, Zhang D et al. · Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae · (2024) · View on PubMed ↗

Colon-targeted engineered postbiotics nanoparticles alleviate osteoporosis through the gut-bone axis.

This preclinical study engineered colon-targeted postbiotics nanoparticles by surface engineering polyvinyl butyrate nanoparticles with shellac resin for sustained release of butyric acid at the colorectal site to treat osteoporosis via the gut–bone axis. The key finding was that the engineered nanoparticles suppressed macrophage inflammatory activation, improved redox balance, and shifted gut-bone–relevant microbial/metabolic pathways to alleviate bone loss. Scientifically, it supports a targeted delivery approach to enhance the efficacy and safety of butyrate-based postbiotics for osteoporosis.

Yu T, Bai R, Wang Z et al. · Nature communications · (2024) · View on PubMed ↗

Red and Green LED Light Therapy: A Comparative Study in Androgenetic Alopecia.

This comparative clinical study evaluated red versus green LED light therapy for androgenetic alopecia (AGA) using an LED helmet delivering 40 J/cm² over 20 minutes to the frontal scalp. The key finding was that the study compared clinical photography, physician 7-point evaluations, patient satisfaction, and other measures to determine relative effectiveness of red and green light in AGA. Clinically, it informs whether green LED LLLT offers added benefit over red/near-infrared approaches for hair thinning.

Tantiyavarong J, Charoensuksira S, Meephansan J et al. · Photodermatology, photoimmunology & photomedicine · (2024) · View on PubMed ↗

Tofersen for SOD1 ALS.

This article reviewed the therapeutic rationale and emerging evidence for tofersen in SOD1-associated amyotrophic lateral sclerosis (ALS). The key finding was that tofersen, an antisense oligonucleotide that reduces SOD1 mRNA expression, showed robust biomarker effects, and that open-label extension data suggested slowed progression in SOD1 ALS despite a Phase III primary endpoint failure. Scientifically and clinically, it supports continued consideration of antisense knockdown strategies for genetically defined SOD1 ALS and highlights the importance of biomarker-driven assessment.

Everett WH, Bucelli RC · Neurodegenerative disease management · (2024) · View on PubMed ↗

Versican Promotes Cardiomyocyte Proliferation and Cardiac Repair.

This study investigated how extracellular matrix changes and fibroblast expansion influence cardiomyocyte proliferation and cardiac repair during neonatal versus adult heart regeneration after injury, using apical resection and myocardial infarction models in mice. It found that specific ECM-associated mechanisms promote cardiomyocyte proliferation and enhance cardiac repair in the neonatal context. These findings are significant for regenerative cardiology because they identify pathways that could be targeted to stimulate heart regeneration after myocardial injury.

Feng J, Li Y, Li Y et al. · Circulation · (2024) · View on PubMed ↗

Environmental health & toxicology (incl. microplastics/air exposures)

A clinical review of cervical cancer.

This narrative clinical review summarized cervical cancer epidemiology, risk disparities, and clinical considerations for prevention and care across populations. It highlighted that incidence and mortality vary by age and by race/ethnicity and socioeconomic access to care, with disproportionate burden in Black and other underserved groups and higher mortality in lower-income countries. The review underscores the need for equitable screening, prevention, and treatment strategies to reduce cervical cancer outcomes.

Pullen RL, Ritchie S · Nursing · (2026) · View on PubMed ↗

The contribution of additives to microplastic aquatic toxicity - A testing approach with model additives on selected aquatic organisms.

This study developed a testing framework to disentangle physical (particle-related) versus chemical effects contributed by microplastic additives using model additives and selected aquatic organisms. It compared toxicity from additive-loaded microplastics, pristine additive-free microplastics, and additives alone while characterizing additive release and considering environmental ageing. The approach advances mechanistic ecotoxicology by clarifying how additives drive microplastic aquatic toxicity.

Perc V, Jemec Kokalj A, Drobne D et al. · Ecotoxicology and environmental safety · (2026) · View on PubMed ↗

The exposomal imprint on rosacea: More than skin deep.

This review synthesized evidence on how the exposome—genetic susceptibility, immune dysregulation, microbiome, hormones, psychosocial stress, and extrinsic triggers such as UV radiation and air pollution—shapes rosacea pathogenesis. The key finding highlighted that recent single-cell transcriptomics implicate fibroblasts as central mediators of inflammatory and vascular pathways in rosacea, alongside emerging roles for non-coding RNAs and RNA modifications. Understanding these multi-layered exposome-driven mechanisms could guide more targeted prevention and therapy for rosacea beyond skin-level explanations.

Grafanaki K, Bakoli Sgourou D, Maniatis A et al. · Journal of the European Academy of Dermatology and Venereology : JEADV · (2026) · View on PubMed ↗

Polyethylene terephthalate microplastics promote pulmonary fibrosis via AKT1, PIK3CD, and PIM1: A network toxicology and multi-omics analysis.

This study investigated whether polyethylene terephthalate microplastics (PET-MPs) exacerbate idiopathic pulmonary fibrosis (IPF) and delineated underlying mechanisms in a multi-omics/toxicology framework. Network toxicology, molecular docking, Mendelian randomization, and single-cell sequencing implicated AKT1, PIK3CD, and PIM1 as key mediators of PET-MP–driven fibrotic signaling. These findings suggest PET-MPs may promote IPF through specific druggable pathways, supporting target-guided risk assessment and mechanistic prioritization for environmental exposures.

Zhao W, Yang S, Hu S et al. · Ecotoxicology and environmental safety · (2025) · View on PubMed ↗

Bat genomes illuminate adaptations to viral tolerance and disease resistance.

This comparative genomics study analyzed reference-quality genomes from ten bat species (Bat1K project) and performed selection analyses across 115 mammalian genomes to identify genomic correlates of viral tolerance and disease resistance. The key finding was an enrichment of adaptive signatures in immune genes in bats compared with other mammalian orders, consistent with bats’ generally asymptomatic viral infections. This advances understanding of host genetic mechanisms underlying zoonotic viral tolerance and may inform strategies for enhancing disease resistance.

Morales AE, Dong Y, Brown T et al. · Nature · (2025) · View on PubMed ↗

Association between second-hand smoke exposure and lung cancer risk in never-smokers: a systematic review and meta-analysis.

This systematic review and meta-analysis quantified the association between second-hand smoke (SHS) exposure and lung cancer risk in never-smokers using epidemiological studies. The key finding was that SHS exposure is associated with increased lung cancer risk among never-smokers (with pooled estimates derived across included studies). Clinically and public-health-wise, it reinforces SHS as a preventable carcinogenic exposure even for people who never smoke.

Possenti I, Romelli M, Carreras G et al. · European respiratory review : an official journal of the European Respiratory Society · (2024) · View on PubMed ↗

Optimizing radiation safety in dentistry: Clinical recommendations and regulatory considerations.

This 2024 review studied radiation safety practices in dentistry by synthesizing clinical recommendations and regulatory considerations for dental radiography and cone-beam computed tomography (CBCT). It found that an expert panel’s guidance emphasizes appropriate imaging selection, justification, optimization to reduce patient dose, and minimizing occupational exposure for dental healthcare providers. The clinical significance is improved safety and compliance through standardized imaging protocols that balance diagnostic value with radiation risk.

Benavides E, Krecioch JR, Connolly RT et al. · Journal of the American Dental Association (1939) · (2024) · View on PubMed ↗

Exposure to metal mixtures and adverse pregnancy and birth outcomes: A systematic review.

This systematic review synthesized evidence on prenatal exposure to metal mixtures and associations with adverse pregnancy and birth outcomes (e.g., low birth weight, preterm birth, and small for gestational age). The review aimed to strengthen and assess the consistency of mixture-based risk estimates, addressing a gap where prior studies often analyzed metals individually rather than as real-world mixtures. The results are intended to guide future research designs and public health policy on environmental metal mixture exposures during pregnancy.

Issah I, Duah MS, Arko-Mensah J et al. · The Science of the total environment · (2024) · View on PubMed ↗

Generated automatically on May 10, 2026 from PubMed’s trending articles. Summaries are AI-generated; always consult the original publication for clinical or research decisions.

← All Trending Digests

PubMed Trending Research Digest — May 10, 2026

PubMed Trending Research Digest — May 10, 2026

Overview

Psychiatric risk prediction & treatment algorithms

Modifiable risk factors and risk of schizophrenia and bipolar disorder across severities of genetic risk.

The global prevalence of eating disorders in children and young people: a systematic review and meta-analysis.

INTEGRATE: international guidelines for the algorithmic treatment of schizophrenia.

Metformin for the Prevention of Antipsychotic-Induced Weight Gain: Guideline Development and Consensus Validation.

Transforming nursing work environments: the impact of organizational culture on work-related stress among nurses: a systematic review.

Correlation between ethical sensitivity and humanistic care ability among undergraduate nursing students: a cross-sectional study.

Six types of loves differentially recruit reward and social cognition brain areas.

Evaluating Monitoring Guidelines of Clozapine-Induced Adverse Effects: a Systematic Review.

Reproductive biology & germ cell development

Male germ cell-specific deletion of Eif5 causes the apoptosis of mouse progenitor spermatogonia by excessive endoplasmic reticulum stress and defective DNA repair.

PGC-derived migrasomes couple PGC proliferation with migration.

R-loops orchestrate RNAPII transcriptional reprogramming for the maternal-to-zygotic transition.

Intermittent fasting boosts sexual behavior by limiting the central availability of tryptophan and serotonin.

The modeling of human implantation and early placentation: achievements and perspectives.

Polycystic ovary syndrome.

Clinical Relevance of Vaginal and Endometrial Microbiome Investigation in Women with Repeated Implantation Failure and Recurrent Pregnancy Loss.

Metabolic health, diabetes & diet–microbiome–bile acid axes

Oat β-glucan reshapes gut microbiota to enhance glucose homeostasis via coordinated modulation of bile acid conjugation and succinate-dependent intestinal gluconeogenesis.

Comparative Evaluation of a Low-Carbohydrate Diet and a Mediterranean Diet in Overweight/Obese Patients with Type 2 Diabetes Mellitus: A 16-Week Intervention Study.

Neurotechnology & neuromodulation

Large-scale single-neuron recording in the human cortex using an ultra-flexible electrode array.

Catalytic neural stem cell exosomes for multi-stage targeting and synergistical therapy of retinal ischemia-reperfusion injury.

Low-intensity transcranial focused ultrasound suppresses pain by modulating pain-processing brain circuits.

Preclinical Characterization of AZD9574, a Blood-Brain Barrier Penetrant Inhibitor of PARP1.

Transcutaneous Electrical Stimulation for Neurogenic Bladder After Spinal Cord Injury: A Systematic Review and Meta-Analysis.

Cancer immunotherapy biomarkers & resistance mechanisms

Phenotype of circulating tumor-reactive T cells predicts immune checkpoint inhibitor response in non-small cell lung cancer.

SLC2A1+ tumour-associated macrophages spatially control CD8+ T cell function and drive resistance to immunotherapy in non-small-cell lung cancer.

The immune microenvironment of colorectal cancer.

Autophagy in cancer development, immune evasion, and drug resistance.

Disrupting B and T-cell collaboration in autoimmune disease: T-cell engagers versus CAR T-cell therapy?

Biomarker-directed targeted therapy plus durvalumab in advanced non-small-cell lung cancer: a phase 2 umbrella trial.

Cancer genomics, multi-omics & biomarker signatures

Multi-omics and machine learning reveal DPPC as a key contributor to colorectal cancer progression and tumor immune microenvironment remodeling.

RNA m1A methyltransferase TRMT61A promotes colorectal tumorigenesis by enhancing ONECUT2 mRNA stability and is a potential therapeutic target.

Mapping early human blood cell differentiation using single-cell proteomics and transcriptomics.

Blood plasma proteome-wide association study implicates novel proteins in the pathogenesis of multiple cardiovascular diseases.

HER2DX and survival outcomes in early-stage HER2-positive breast cancer: an individual patient-level meta-analysis.

Cancer of the corpus uteri: A 2025 update.

Noninvasive prognostic classification of ITH in HCC with multi-omics insights and therapeutic implications.

A novel glycolysis-related gene signature for predicting prognosis and immunotherapy efficacy in breast cancer.

Tumor microenvironment, stromal interactions & fibrosis

Endothelial cells sense temozolomide resistance to facilitate monocyte-derived macrophage infiltration in glioblastoma.

Spatial-reprogramming derived GPNMB+ macrophages interact with COL6A3+ fibroblasts to enhance vascular fibrosis in glioblastoma.

ANGPTL2+cancer-associated fibroblasts and SPP1+macrophages are metastasis accelerators of colorectal cancer.

Targeted therapies & drug mechanisms (oncology)

SIRT3 deacetylates STEAP4 to modulate cuproptosis sensitivity via mitochondrial metabolic reprogramming in HBV-related HCC.

Comparative effectiveness of atogepant and rimegepant for migraine prevention in Japanese patients: an anchored matching-adjusted indirect comparison.

Structural basis for the recruitment and selective phosphorylation of Akt by mTORC2.

Guanine nucleotides drive ribosome biogenesis and glycolytic reprogramming in acute myeloid leukemia stem cells.

Antibody-oligonucleotide conjugates in cancer therapy: Potential and Promise.

PD-1 antibody camrelizumab plus apatinib and SOX as first-line treatment in patients with AFP-producing gastric or gastro-esophageal junction adenocarcinoma (CAP 06): a multi-center, single-arm, phase 2 trial.

Asciminib in Newly Diagnosed Chronic Myeloid Leukemia.

Neoadjuvant FOLFIRINOX versus upfront surgery for resectable pancreatic head cancer (NORPACT-1): a multicentre, randomised, phase 2 trial.

TROPION-Breast02: Datopotamab deruxtecan for locally recurrent inoperable or metastatic triple-negative breast cancer.

Gene therapy & oligonucleotide therapeutics

Can Gene Therapy Revolutionize Treatment of Neovascular Age-Related Macular Degeneration.

Tofersen: A Review in Amyotrophic Lateral Sclerosis Associated with SOD1 Mutations.

Tofersen for SOD1 amyotrophic lateral sclerosis: a systematic review and meta-analysis.

Neurodegeneration & cognitive disorders

Diagnostic accuracy of the Gold Coast Criteria for amyotrophic lateral sclerosis: a systematic review and meta-analysis.

Comparative Efficacy and Safety of Monoclonal Antibodies for Cognitive Decline in Patients with Alzheimer’s Disease: A Systematic Review and Network Meta-Analysis.

Cardiovascular screening, risk prediction & procedural care

Cardiac Screening for Conditions Associated With Sudden Cardiac Death: Yield, Interventions, and SCA/SCD Incidence in 104,369 Young Individuals.

Neuraxial anesthesia and pain management for cesarean delivery.

Medication Adherence in Hypertension: A Cluster Randomized Clinical Trial.

Spotlight on the 2024 ESC/EACTS management of atrial fibrillation guidelines: 10 novel key aspects.

Large Language Model Influence on Diagnostic Reasoning: A Randomized Clinical Trial.

Impact of high-power short-duration atrial fibrillation ablation technique on the incidence of silent cerebral embolism: a prospective randomized controlled study.

Renal disease & proteinuria/immune kidney therapies

Diabetic retinal disease.

Glucagon-like Peptide-1 Receptor Agonist Impact on Chronic Ocular Disease Including Age-Related Macular Degeneration.

Large-Scale Proteomics Improve Prediction of Chronic Kidney Disease in People With Diabetes.

Comparative Effectiveness of Glucagon-Like Peptide-1 Receptor Agonists, Sodium-Glucose Cotransporter 2 Inhibitors, Dipeptidyl Peptidase-4 Inhibitors, and Sulfonylureas for Sight-Threatening Diabetic Retinopathy.

A phase 2b, randomized, double-blind, placebo-controlled, clinical trial of atacicept for treatment of IgA nephropathy.

Infectious disease, sepsis & immune regulation