PubMed Trending Research Digest — May 25, 2026

Automated digest · 99 articles · 15 research areas · May 25, 2026

Overview

Across this week’s set, a dominant theme is the move toward more precise risk stratification using data-driven biomarkers and stratified phenotyping. In neurodegeneration, multiple studies use genetic risk (e.g., GBA1 variant risk for synucleinopathies), transcriptomic machine learning, and objective digital measures (accelerometry circadian phenotypes) to refine early identification and subgrouping. In oncology and cardiology, clustering/phenotyping and multimodal predictive models (e.g., MRI-derived adverse LV remodeling phenotypes after STEMI; PSMA/mpMRI radiomics decision support in biopsy-naïve prostate cancer; plasma proteomic signatures for radiation pneumonitis) emphasize that “who is at risk” can be made more actionable by integrating longitudinal and multi-omic signals rather than relying on single static measures.

A second major thread is immune and inflammation biology as both a mechanistic driver and a therapeutic target. Several papers connect immune pathways to disease progression or treatment resistance—ranging from tumor immune evasion in inflammatory breast cancer and glioblastoma signaling axes, to immune-metabolic crosstalk in NAFLD–osteoporosis and obesity-amplified acute pancreatitis via itaconate/ferroptosis. In autoimmune and inflammatory conditions, mechanistic targets such as TLR8/AP-1 in systemic sclerosis, pyroptosis control via butyrate–AhR signaling, and neuroimmune protection via TRPV1+ sensory nerves in kidney ischemia-reperfusion injury highlight a broader shift toward pathway-specific interventions.

Finally, the digest reflects continued emphasis on translational therapeutics and supportive care across diverse systems: from engineered exosome delivery to block α-synuclein aggregation, to AAV gene replacement long-term safety considerations in SMA, to nonpharmacologic interventions (electroacupuncture, prenatal exercise) and practical clinical guidance (e.g., imaging consensus for VKH disease, ICU management approaches for PAH decompensation). Together, these studies underscore a unifying direction in biomedical research: combine mechanistic insight with better measurement and stratification to improve both efficacy and safety.

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Neurodegenerative disease genetics & biomarkers (ALS/PD/AD)

ERVK activity in CD8+ T cell immune cell compartment in patients with ALS.

This study examined endogenous retrovirus-K (ERVK) integrase (IN) expression in immune-cell compartments by analyzing peripheral blood mononuclear cells (PBMCs) from patients with amyotrophic lateral sclerosis (ALS). The authors report ERVK activity/IN-associated expression in CD8+ T cells (and related immune subsets) in ALS, linking ERVK presence to a DNA-damage–relevant mechanism. These findings suggest ERVK IN may contribute to ALS-associated genomic instability and identify a potential immune-cell target for biomarker development or immunomodulatory strategies.

Sharma S, Cortés-Pérez C, Bird S et al. · Journal of neuroinflammation · (2026) · View on PubMed ↗ · Free PDF ↗

Proximity proteomics reveals a co-evolved LRRK2-regulatory network linked to centrosomes.

This study used BioID proximity proteomics to map LRRK2 (leucine-rich repeat kinase 2) interactors and applied an evolutionary/structural bioinformatics pipeline to interpret co-evolved protein networks. The authors identified a co-evolved LRRK2 regulatory module enriched for cytoskeletal components associated with centrosomes and microtubules. Scientifically, this refines LRRK2 biology relevant to familial and idiopathic Parkinson’s disease and points to centrosome–microtubule pathways as mechanistic targets.

Eckert M, Miglionico P, Izzi F et al. · EMBO reports · (2026) · View on PubMed ↗ · Free PDF ↗

The GBA1 p.E427K (p.E388K) Variant Is a Risk Factor for Synucleinopathies: A Meta-Analysis.

This meta-analysis evaluated whether the GBA1 p.E427K (p.E388K) variant is associated with risk of synucleinopathies, using case-control data from Parkinson’s disease and related disorders. Across pooled cohorts, carriers of GBA1 p.E427K showed increased odds of synucleinopathy compared with non-carriers. These findings strengthen GBA1 p.E427K as a genetic risk factor that may help refine genetic risk stratification for Parkinson’s disease and other synucleinopathies.

Chifamba LV, Parlar SC, Somerville EN et al. · Movement disorders : official journal of the Movement Disorder Society · (2026) · View on PubMed ↗ · Free PDF ↗

The association between asthma and ADHD in children and adolescents: An observational study and a meta-analysis of Mendelian randomization studies.

This observational study and meta-analysis of Mendelian randomization (MR) studies investigated the association between asthma and ADHD in children and adolescents. Using NHANES 1999–2004 for observational analyses and ADHD genome-wide association study data for MR, the study evaluated whether genetic liability to ADHD is associated with asthma risk (and vice versa) in youth. The combined evidence approach helps clarify whether the asthma–ADHD relationship is likely causal rather than purely correlational.

Lan X, Zhong N, Tang Z et al. · Medicine · (2026) · View on PubMed ↗ · Free PDF ↗

Identification of Reliable Biomarkers for ALS Through Machine Learning Approach.

This study used machine learning on RNA-Seq transcriptome data to identify molecular biomarkers for amyotrophic lateral sclerosis (ALS) using motor neuron disease patient and healthy control datasets from GEO. The key finding was that an ensembled ML pipeline with feature selection produced candidate ALS biomarkers from high-dimensional gene expression profiles. Scientifically, it provides a data-driven framework for discovering more reliable ALS biomarkers despite disease heterogeneity.

Yadav R, Pragya P, Agastinose Ronickom JF · Studies in health technology and informatics · (2026) · View on PubMed ↗ · Free PDF ↗

A Consensus Clustering Approach to Amyotrophic Lateral Sclerosis Phenotyping.

This paper studied ALS phenotyping by applying consensus clustering to clinical data from a battery of examinations to identify stable patient subgroups. The key finding was that consensus clusters aligned with known clinical phenotypes, showing consistent profiles for bulbar-onset ALS driven by onset characteristics, while spinal-onset ALS showed greater within-phenotype heterogeneity. This supports more reproducible, data-driven ALS subgrouping that could improve clinical trial stratification and phenotype-specific research.

Ferraro PM, Narteni S, Lenatti M et al. · Studies in health technology and informatics · (2026) · View on PubMed ↗ · Free PDF ↗

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Neurodegenerative disease mechanisms & therapeutics (ALS/PD/AD)

Engineered neuronal exosomes mediate α-synuclein clearance to ameliorate Parkinson’s disease.

This study developed engineered neuronal exosomes loaded with an α-synuclein aggregation-blocking peptide (sPep) to promote α-synuclein clearance in a Parkinson’s disease (PD) therapeutic context. The engineered exosomes extended blood circulation half-life (reported as 3.8 h), improved brain targeting (higher brain signal proportion than free dye), and were designed to block α-synuclein aggregation. This approach supports a drug-delivery platform using exosome engineering plus peptide-mediated aggregation inhibition as a potential disease-modifying strategy for PD.

Chen L, Lin X, Fu M et al. · Journal of nanobiotechnology · (2026) · View on PubMed ↗ · Free PDF ↗

Cryo-EM Structure of the TRPC1/5 Heteromer Enables Design of Antidepressant and Anxiolytic Drug with Reduced Side Effects.

This study determined the cryo-EM structure of the TRPC1/TRPC5 heterotetramer in order to understand how the TRPC1 subunit shapes TRPC5-like channel function and to enable rational drug design. The 2.8 Å structure revealed an asymmetric assembly (three TRPC5 around one TRPC1) with a TRPC1–TRPC5 interface ligand-binding pocket absent from TRPC5 homomers, producing an altered ion conduction pathway and gating/selectivity. Using this structural pocket, the authors designed JD03-02, a high-affinity TRPC1/TRPC5 antagonist intended to achieve antidepressant/anxiolytic effects with reduced side effects.

Chen Y, Che T, Cheng X et al. · Nature communications · (2026) · View on PubMed ↗ · Free PDF ↗

Astrocyte activation in the ventrolateral medulla modulates breathing and arousal states.

This study investigated whether astrocytes in the ventral respiratory column (VRC) regulate breathing and arousal states in alert mice, focusing on Aldh1l1 astrocytes. It showed that a subset of Aldh1l1 cells activates prior to sigh generation and is recruited by hypoxia, and that chemogenetic or optogenetic activation increased the probability of sigh generation and modulated arousal-related behaviors. Scientifically, the work identifies a specific astrocyte population as a sensor/effector for respiratory-to-arousal transitions, suggesting new targets for disorders of breathing and sleep-wake regulation.

Oliveira LM, Miranda NC, Lim HK et al. · Nature communications · (2026) · View on PubMed ↗ · Free PDF ↗

Electroacupuncture Improves the Learning and Memory by Modulating Hippocampal Glucose Metabolism through IGF1/IGF1R Signaling in Alzheimer’s Disease.

The study tested whether electroacupuncture (EA) improves learning and memory in a mouse model of Alzheimer’s disease (5×FAD) by altering hippocampal glucose metabolism via IGF1/IGF1R signaling. EA reduced β-amyloid deposition and attenuated cognitive deficits while enhancing hippocampal glucose metabolism and improving information processing in brain metabolic networks. This is clinically significant because it supports EA as a potential non-pharmacologic strategy targeting IGF1/IGF1R-mediated metabolic dysfunction in Alzheimer’s disease.

Liang S, Zhang Q, Wang X et al. · Advanced science (Weinheim, Baden-Wurttemberg, Germany) · (2026) · View on PubMed ↗ · Free PDF ↗

Comparison of blood dopamine in Parkinson’s patients treated with levodopa carbidopa entacapone vs levodopa benserazide: A randomized controlled trial.

This single-center randomized controlled trial compared short-term plasma dopamine effects of levodopa/carbidopa/entacapone (LCE) versus levodopa/benserazide (LB) in early-stage, unilateral Parkinson’s disease patients. The study measured and compared blood dopamine levels after treatment with each regimen. These biochemical comparisons may help clinicians understand which combination better improves short-term dopamine availability in early Parkinson’s disease.

Korucu O, Özdemir S, Türkeş GF et al. · Medicine · (2026) · View on PubMed ↗ · Free PDF ↗

The effects of electroacupuncture and the Otago Exercise Program in older adults with sarcopenia: A randomized controlled study.

This assessor-blinded randomized controlled trial evaluated whether electroacupuncture (EA) combined with the Otago Exercise Program (OEP) improves outcomes in older adults with sarcopenia compared with OEP alone. One group received OEP 5 times/week for 12 weeks, while the EA+OEP group received the same OEP plus EA at ST31, ST32, GB34, and ST36 three times/week for 12 weeks. The trial’s results are intended to guide nonpharmacologic treatment recommendations for sarcopenia in older adults.

Wu W, Cao Y, Zhang Y et al. · Medicine · (2026) · View on PubMed ↗ · Free PDF ↗

Mitochondrial DNA release contributes to neuropathic pain via a cGAS-STING-IRF3-CMPK2-associated immunometabolic feedback mechanism.

This preclinical study investigated how mitochondrial DNA (mtDNA) release contributes to neuropathic pain (NP) via a cGAS-STING-IRF3-CMPK2-associated immunometabolic feedback mechanism in a mouse peripheral nerve injury model. The key finding was that spinal cord analyses showed mtDNA release and activation of the cGAS-STING-IRF3 pathway, and that genetic silencing of CMPK2 implicated this immunometabolic axis in sustaining neuroinflammation. Scientifically, it identifies a mechanistic targetable pathway linking mitochondrial dysfunction to innate immune signaling in NP.

Wang B, Zeng H, Zhan H et al. · Journal of translational medicine · (2026) · View on PubMed ↗ · Free PDF ↗

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Neuroimaging & digital biomarkers in neurodegeneration

Angiogenic T cells and cognitive function in older adults with type 2 diabetes treated with GLP-1 receptor agonists.

A cross-sectional study of 154 older adults (60–80 years) with type 2 diabetes mellitus compared circulating angiogenic T cells (“Tang cells”) and cognitive function between those treated with GLP-1 receptor agonists plus metformin versus metformin alone. The key finding (as indicated by the study aim and truncated results) was the association between Tang cells and cognitive performance and the potential modulation of this relationship by GLP-1RA therapy. Scientifically, it links immune angiogenic capacity to cognitive outcomes in T2DM and suggests GLP-1RA treatment may influence neurovascular/immune pathways relevant to cognitive decline.

Longo M, Caruso P, Auriemma MC et al. · Aging clinical and experimental research · (2026) · View on PubMed ↗ · Free PDF ↗

In vivo profiling of astrocyte secretome reveals brain-region specific regulatory networks in a mouse model of amyloid pathology.

This study profiled the astrocyte secretome in vivo in a mouse model of amyloid pathology using TurboID proximity labeling to map brain-region–specific regulatory networks. Astrocyte-derived secretory protein changes emerged early and differed by region, with early entorhinal cortex secretome alterations enriched for metabolic pathways. The findings clarify how region-specific astrocyte secretomes may shape neurodegenerative progression and provide candidate secreted regulators for Alzheimer’s disease–related mechanisms.

Jiang Q, Hu JN, Dong HM et al. · Molecular neurodegeneration · (2026) · View on PubMed ↗ · Free PDF ↗

Clinical, structural, and functional MRI features predicting PIRMA at 5-year follow-up in multiple sclerosis.

This study aimed to predict progression independent of relapse and MRI activity (PIRMA) at 5 years in multiple sclerosis by identifying baseline clinical, structural, and functional MRI features. It found that certain baseline MRI measures—such as white matter and gray matter volumes, spinal cord area, and resting-state functional connectivity from nine networks—differentiated PIRMA progressors from stable patients among individuals without clinical or MRI activity at 5-year follow-up. Scientifically, it supports using multimodal MRI biomarkers to forecast long-term disability progression beyond relapse/MRI activity.

Barbuti E, Piervincenzi C, Baione V et al. · Multiple sclerosis (Houndmills, Basingstoke, England) · (2026) · View on PubMed ↗

Prevalence and associated factors of subjective cognitive decline (SCD Plus): a cross-sectional analysis of three population-based European cohorts.

This cross-sectional analysis studied the prevalence and correlates of subjective cognitive decline (SCD Plus) in adults aged ≥60 years without dementia across three harmonized population-based European cohorts (LIFE-Adult-Study, English Longitudinal Study of Ageing, and Cognitive Function and Ageing Study). The key finding was that SCD Plus prevalence and associated factors could be estimated using a common operational definition derived from available cohort variables. Scientifically, it strengthens early Alzheimer’s disease risk characterization by providing population-based evidence for SCD Plus criteria.

Zülke AE, Luppa M, Sander C et al. · Alzheimer’s research & therapy · (2026) · View on PubMed ↗ · Free PDF ↗

GWAS-by-subtraction reveals new genetic architecture and health implications of type 2 diabetes-independent gestational diabetes mellitus.

This prospective cohort study examined whether Alzheimer’s disease (AD) polygenic risk scores and APOE ε4 dose are reflected in wrist accelerometer-derived circadian rest-activity rhythms and whether those rhythms predict incident dementia/AD in 94,241 UK Biobank participants. The key finding was that genetic AD risk (including APOE ε4 dose) relates to specific accelerometry-derived circadian phenotypes and that these phenotypes can forecast subsequent dementia/AD. Clinically, it supports objective, scalable circadian biomarkers as potential early indicators of AD risk.

Zhou S, Ran Z, Li Y et al. · Genome medicine · (2026) · View on PubMed ↗ · Free PDF ↗

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Cardiovascular trials, risk windows & imaging phenotypes

Direct oral anticoagulants versus vitamin K antagonists for atrial fibrillation patients on dialysis: A systematic review and meta-analysis of randomized controlled trials and real-world evidence.

This systematic review and meta-analysis evaluated efficacy and safety of direct oral anticoagulants (DOACs) versus vitamin K antagonists (VKAs) for atrial fibrillation in end-stage renal disease patients on dialysis, using both randomized controlled trials and real-world evidence. The study assessed outcomes including ischemic stroke, major bleeding, and all-cause mortality to determine the optimal anticoagulant strategy in a population excluded from pivotal DOAC trials. Clinically, it aims to resolve uncertainty about anticoagulation choice in dialysis patients with AF by synthesizing the best available comparative evidence.

Shaheen O, Hamdy M, Afifi IA et al. · Journal of thrombosis and thrombolysis · (2026) · View on PubMed ↗

Lactylation landscape of mitochondrial proteins in myocardial infarction.

This study mapped the mitochondrial lactylation landscape (“mitochondrial lactylome”) in myocardial infarction and tested how lactate transport modulation affects mitochondrial metabolism and redox homeostasis. The key finding was that MI causes extensive remodeling of mitochondrial protein lactylation, linking lactate-driven post-translational changes to mitochondrial dysfunction and altered redox balance. Scientifically, it identifies mitochondrial lactylation as a mechanistic layer of metabolic reprogramming in MI.

Kadam A, Kashyap S, Samantaray K et al. · Redox biology · (2026) · View on PubMed ↗ · Free PDF ↗

Advanced glycation end-products exacerbate myocardial ischemia/reperfusion injury by promoting mitochondrial oxidative damage and PANoptosis in diabetes mellitus.

This study examined how advanced glycation end-products (AGEs) worsen myocardial ischemia/reperfusion injury in diabetes mellitus using hypoxia/reoxygenation (H/R)-stimulated cardiomyocytes. The key finding was that AGE-primed cardiomyocytes developed mitochondrial oxidative damage (increased mtROS, membrane potential loss, ATP depletion, mtDNA and cytochrome c release) and impaired antioxidant defense via the RAGE–Nrf2–SOD2 axis, while also activating the AIM2–ZBP1 PANoptosome. Clinically, it positions the AGE–RAGE–Nrf2–SOD2 and PANoptosis pathways as actionable targets to mitigate diabetic MI/RI injury.

Yang J, Zhang J, Huang R et al. · Redox biology · (2026) · View on PubMed ↗ · Free PDF ↗

Nogo-B attenuates vascular calcification by activating NRF2-SLC7A11 to enhance antioxidant defense.

This study investigated whether Nogo-B attenuates vascular calcification by activating NRF2–SLC7A11 antioxidant signaling using C57BL/6J mice and smooth muscle cell–specific Nogo knockout mice (NogoSMKO). The key finding was that vascular calcification induced by nicotine and vitamin D3 (VD3) was reduced by Nogo-B activity, which enhanced NRF2-driven SLC7A11 expression and antioxidant defense. Scientifically and therapeutically, it suggests the Nogo-B→NRF2–SLC7A11 axis as a potential target to prevent or slow vascular calcification.

Liang D, Zhang W, Zhang H et al. · Redox biology · (2026) · View on PubMed ↗ · Free PDF ↗

Rethinking Post-Infarction Remodeling: Identification and Validation of Data-Driven Cardiac MRI Phenotypes for Risk Stratification.

This prospective longitudinal study in reperfused ST-elevation myocardial infarction (STEMI) patients used data-driven unsupervised clustering of longitudinal cardiac MRI (CMR) measurements to identify prognostic adverse left ventricular remodeling (ALVR) phenotypes. Compared with conventional ALVR definitions based on changes in left ventricular end-diastolic volume index and ejection fraction, the derived CMR phenotypes provided improved risk stratification in a derivation cohort (n=337) and independent validation cohort (n=190). The clinical significance is that MRI-based phenotyping may better predict outcomes after STEMI and enable more precise post-infarction management.

Xiang JY, Wu J, Zhao Y et al. · European heart journal. Cardiovascular Imaging · (2026) · View on PubMed ↗

Cardiovascular events after acute myocardial infarction complicated by low ejection fraction and/or congestion: a landmark analysis of the PARADISE-MI trial.

This landmark post hoc analysis of the PARADISE-MI randomized trial studied the timing and distribution of subsequent cardiovascular events after acute myocardial infarction (AMI) complicated by left ventricular systolic dysfunction and/or pulmonary congestion in 5661 patients. Cardiovascular events peaked early after AMI, and the analysis compared sacubitril/valsartan versus ramipril effects separately in early (≤3 months) and late (>3 months) post-AMI periods. Clinically, the results inform when patients are at highest risk and whether ARNI-based therapy provides differential benefit across early versus late post-AMI windows.

Boulet J, Rouleau JL, Petrie M et al. · European journal of heart failure · (2026) · View on PubMed ↗

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Endocrine/metabolic disease risk & biomarkers (diabetes/obesity/testosterone/vitamin D)

Comparative fall risk of patients treated with novel androgen receptor antagonists in prostate cancer: a systematic review and meta-analysis.

This systematic review and meta-analysis evaluated fall risk in patients with prostate cancer treated with novel androgen receptor antagonists (enzalutamide, apalutamide, darolutamide) versus placebo or non-steroidal antiandrogens (NSAA) using Phase 2/3 randomized controlled trials. The key finding was a drug-specific assessment of relative risk for all-grade falls and grade ≥3 falls across these ARPIs. Clinically, the results help quantify and compare fall hazards among ARPIs to guide risk mitigation and treatment selection in advanced prostate cancer.

Wei C, Cai Y, Huang Z et al. · BMC cancer · (2026) · View on PubMed ↗ · Free PDF ↗

Beyond glycemic control: differential effects of empagliflozin and sitagliptin on insulin sensitivity and a shared increase in adropin in type 2 diabetes.

This randomized, open-label, parallel-group superiority trial compared empagliflozin versus sitagliptin (both added to metformin) in adults with type 2 diabetes mellitus (T2DM), focusing on insulin sensitivity and the hepatokine adropin. Both treatments produced a shared increase in serum adropin, while showing differential effects on insulin sensitivity and related metabolic/inflammatory outcomes. The study suggests that beyond glycemic control, SGLT2 inhibition and DPP-4 inhibition may modulate insulin resistance through partially overlapping adropin-related pathways.

Taha OS, Azami G, Saed L et al. · BMC endocrine disorders · (2026) · View on PubMed ↗ · Free PDF ↗

Multi-region proteomic mapping identifies FTL1 and SERPINA3K as protective factors in cardiac aging.

This study performed region-resolved quantitative proteomics across multiple murine cardiac regions at 3, 12, and 20 months to identify molecular factors associated with cardiac aging. Multi-region proteomic mapping highlighted FTL1 and SERPINA3K as protective factors, implying they track with reduced age-associated deterioration in specific heart regions. These proteins provide candidate biomarkers and mechanistic targets for interventions aimed at preventing or slowing cardiovascular decline with age.

Huang J, Sun X, Liu H et al. · Cell death & disease · (2026) · View on PubMed ↗ · Free PDF ↗

Sport-specific prevalence of Relative Energy Deficiency in Sport (REDs) risk among Finnish female national- and international-level athletes.

This cross-sectional study evaluated the sport-specific prevalence of Relative Energy Deficiency in Sport (REDs) risk among Finnish female athletes at national and international levels and active non-athletes using the REDs Clinical Assessment Tool Version 2. Using baseline data from endurance (n=50), speed/power (n=50), team/interval sports (n=37), and non-athletes (n=20), the authors reported differences in REDs risk prevalence by sport type. The findings help identify which female sport categories may need earlier screening and intervention to prevent REDs-related health consequences.

Wynne-Ellis M, Kuljukka A, Mikkonen RS et al. · Journal of science and medicine in sport · (2026) · View on PubMed ↗ · Free PDF ↗

Post-competition recovery in natural physique athletes: body composition, metabolic adaptation, and refeeding responses.

This study examined post-competition recovery in natural physique athletes by tracking body composition, metabolic adaptation, and refeeding responses across a 12-week period. The key finding was that recovery involved measurable changes in body composition and metabolic/thyroid-related parameters alongside psychological shifts, with responses influenced by the athletes’ refeeding strategies. This informs evidence-based recovery and nutrition planning for physique athletes after contest preparation.

Buechel C, Pumpa K, Etxebarria N et al. · Journal of the International Society of Sports Nutrition · (2026) · View on PubMed ↗ · Free PDF ↗

The interplay between vitamin D status and exerkine signaling: implications for exercise adaptation in athletes: narrative review.

This narrative review examined evidence linking vitamin D status and supplementation to modulation of exercise-responsive signaling molecules (“exerkines”) relevant to exercise adaptation in athletic populations. It proposes a unifying “vitamin D–exerkine axis” model in which vitamin D’s pleiotropic actions (immunomodulatory and myotropic) may influence exerkine signaling and thereby training adaptation and recovery. The synthesis is significant because it frames testable mechanistic and clinical hypotheses for optimizing athlete training and recovery through vitamin D–exerkine interactions.

Kim DH · Journal of the International Society of Sports Nutrition · (2026) · View on PubMed ↗ · Free PDF ↗

Chlorella Polysaccharide Extract Attenuates Skin Aging via MAPK Pathway Suppression: Implications for Cosmetic Dermatology.

This experimental study tested whether chlorella polysaccharide extract (CPE) attenuates skin aging in an oxidative-stress-induced zebrafish model and probed mechanism via MAPK pathway suppression. The key finding was that CPE reduced oxidative stress and senescence markers (including ROS, MDA, SA-β-gal activity, and inflammatory readouts) while modulating antioxidant enzymes (SOD, CAT) and anti-inflammatory IL-10, consistent with MAPK pathway inhibition. These results support CPE as a mechanistically grounded candidate for cosmetic dermatology interventions targeting oxidative-stress-driven skin aging.

Zhang M, Guo Y, Jiang X et al. · Journal of cosmetic dermatology · (2026) · View on PubMed ↗ · Free PDF ↗

Novel Amylin-Based Therapies for Weight Management in Adults With Overweight or Obesity Without Diabetes: A Network Meta-Analysis.

This frequentist random-effects network meta-analysis compared novel long-acting amylin-based therapies (ABTs) for weight management in adults with overweight or obesity without diabetes using randomized controlled trials. The key finding was that ABTs produced dose- and agent-dependent reductions in percent body weight from baseline and improved anthropometric outcomes, while also characterizing overall and specific gastrointestinal adverse event risks. Clinically, the ranked comparative effectiveness and GI safety profile help clinicians and researchers select among emerging amylin-based anti-obesity options.

Kamrul-Hasan ABM, Khalil I, Mahajan K et al. · Endocrinology, diabetes & metabolism · (2026) · View on PubMed ↗ · Free PDF ↗

Testosterone and docetaxel treatment effect on mortality risk in nonmetastatic high-risk prostate cancer: A predictive biomarker analysis.

This predictive biomarker analysis examined whether baseline testosterone level (low vs normal) modifies mortality benefit from adding docetaxel to radiation therapy plus androgen deprivation therapy (RT+ADT) in nonmetastatic high-risk prostate cancer. Using discovery and validation cohorts drawn from two randomized trials, the study assessed differential mortality risk by testosterone subgroup in patients receiving docetaxel+RT+ADT versus RT+ADT alone. If confirmed, baseline testosterone could help personalize escalation with docetaxel in high-risk localized prostate cancer.

Zeng J, Chen MH, Wu J et al. · Cancer · (2026) · View on PubMed ↗ · Free PDF ↗

Higher light at night exposure is associated with increased risk of diabetes mellitus: A cross-sectional study of the NHANES database.

This cross-sectional study used NHANES 2011–2014 data to test whether objectively measured higher light at night (LAN) exposure is associated with diabetes mellitus (DM) risk among US adults. Multivariable logistic regression assessed the relationship between LAN levels and DM status in participants with complete LAN and DM data. The results support LAN as a potential environmental risk factor for DM that could inform public health interventions targeting nighttime light exposure.

He L, Zeng C, Liu C et al. · Medicine · (2026) · View on PubMed ↗ · Free PDF ↗

What Can We Learn From Longitudinal Measurements of Liver Stiffness in Metabolic Dysfunction-Associated Steatotic Liver Disease?

This review studied longitudinal changes in liver stiffness measurement (LSM) obtained by vibration-controlled transient elastography in metabolic dysfunction-associated steatotic liver disease (MASLD). The key finding was that longitudinal LSM trajectories may better reflect disease evolution and treatment response than static measurements, with implications for liver-related event (LRE) risk assessment and threshold interpretation. Scientifically and clinically, it synthesizes evidence to guide how clinicians and researchers might use repeated non-invasive LSM to monitor MASLD progression.

André-Dumont S, Lanthier N · Liver international : official journal of the International Association for the Study of the Liver · (2026) · View on PubMed ↗

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Reproductive health & pregnancy disorders

Genome-wide meta-analysis identifies genetic drivers of bile acid metabolism in intrahepatic cholestasis of pregnancy.

Genome-wide association study meta-analysis was performed in 4,738 women with prior intrahepatic cholestasis of pregnancy (ICP) and 436,834 female controls from FinnGen, deCODE, the Estonian Biobank, the Danish Blood Donor Study, and Copenhagen Hospital Biobank to identify genetic drivers of bile acid metabolism. The analysis detected 26 genome-wide significant loci (10 novel), and prioritized associated genes using lead-SNP expression quantitative trait loci (eQTL) expression quantification. These findings refine the genetic architecture of ICP and highlight bile-acid–related pathways that could inform risk stratification and mechanistic targets for pregnancy cholestasis.

Tyrmi JS, Karjalainen J, Venkatesh SS et al. · Nature communications · (2026) · View on PubMed ↗

Cuproptosis causes meiotic metaphase I arrest by disrupting mitochondrial functions in oocytes.

This study assessed whether cuproptosis, a copper-dependent cell death pathway, affects meiotic maturation in mouse oocytes. Treatment with Cu(II)-elesclomol (ELC-Cu(II)) induced dose-dependent metaphase I arrest by activating the spindle assembly checkpoint through defective spindle organization and impaired kinetochore–microtubule attachments, alongside cuproptosis marker changes including intracellular copper accumulation, FDX1 downregulation, and protein aggregation. The results connect cuproptosis to impaired mitochondrial function and meiotic failure, informing potential strategies to protect fertility under copper dysregulation.

Lu YH, Wang C, Chen LN et al. · Cell death discovery · (2026) · View on PubMed ↗ · Free PDF ↗

Polycystic ovary syndrome and its association with reproductive cancers in women.

This retrospective cohort study assessed whether polycystic ovary syndrome (PCOS) is associated with incident female reproductive cancers using Optum’s de-identified Clinformatics Data Mart (2000–2022). Women aged 18–50 without prior reproductive cancer were matched 1:5 on age and diagnosis month to non-PCOS controls, and stabilized inverse probability of treatment weighting was used to estimate risk for breast, uterine, ovarian/fallopian tube, and cervical cancers. The study’s significance is clarifying cancer risk profiles in women with PCOS to inform screening and counseling decisions.

Alur-Gupta S, DiTosto JD, Busse KR et al. · Fertility and sterility · (2026) · View on PubMed ↗

Effects of prenatal exercise interventions on physical activity, sedentary behaviour, maternal health, and pregnancy outcomes: A systematic review and meta-analysis.

This systematic review and meta-analysis evaluated randomized controlled trials of prenatal exercise interventions in pregnant people to assess effects on physical activity, sedentary behavior, maternal health, and pregnancy outcomes. Prenatal exercise improved physical activity and reduced sedentary behavior, with effects varying by intervention characteristics across included trials. These findings support incorporating structured prenatal exercise into maternal health programs while highlighting the need to optimize specific program features for consistent benefits.

Xiang Z, Liu Y, Wang R et al. · International journal of nursing studies · (2026) · View on PubMed ↗

Glucocorticoids in pregnancy: A master-switch for fetal maturation.

This Endocrine Reviews article examined the role of glucocorticoids as a “master-switch” for fetal maturation, emphasizing how the prepartum glucocorticoid surge drives organ development across mammalian species. It explains that preterm birth disrupts this endogenous rise, contributing to lung immaturity and increased short- and long-term respiratory morbidity, and it contextualizes antenatal corticosteroid (ACS) use. The clinical significance is improved mechanistic understanding of why ACS can mitigate preterm complications and how timing of fetal glucocorticoid exposure affects outcomes.

Tan Y, Stark MJ, Clifton VL et al. · Endocrine reviews · (2026) · View on PubMed ↗ · Free PDF ↗

Identifying Novel Biomarkers and Therapeutic Targets for Endometriosis: Integrative Analysis of the Plasma Proteome and Genome.

This integrative genetic–proteomic analysis studied endometriosis (EM) by combining plasma proteome protein quantitative trait loci (pQTLs) from UK Biobank Pharma Proteomics Project with EM genetic associations from FinnGen. Using cis-Mendelian randomization (cis-MR), colocalization, and protein–protein interaction (PPI) analyses, it aimed to identify plasma proteins with causal genetic evidence as novel EM biomarkers and therapeutic targets. The scientific significance is that it leverages causal inference to prioritize targets for EM diagnosis and treatment beyond observational protein association studies.

Zheng J, Yao YL, Chen XZ et al. · Mediators of inflammation · (2026) · View on PubMed ↗ · Free PDF ↗

Migraine in women undergoing fertility treatment: A prospective study.

This prospective study evaluated migraine burden and disability in women undergoing in vitro fertilization (IVF), comparing those with and without a prior history of migraine across the IVF cycle and measuring secondary outcomes including psychological symptoms and estradiol levels. The key finding was that migraine symptoms and associated disability differed between women with versus without baseline migraine history during IVF, in the context of exogenous estrogen exposure. Scientifically and clinically, the study informs counseling and risk stratification for migraine management during fertility treatment cycles.

Jean J, Klein JI, Karashchuk N et al. · Headache · (2026) · View on PubMed ↗

Alzheimer’s disease polygenic risk, APOE ε4 dose, and accelerometer-derived circadian rest-activity rhythms in relation to incident dementia and Alzheimer’s disease in UK Biobank: a prospective cohort study.

This GWAS-by-subtraction study investigated gestational diabetes mellitus (GDM) genetic architecture that is independent of type 2 diabetes (T2D) by subtracting T2D GWAS effects from GDM GWAS effects using genomic structural equation modeling (SEM). The key finding was identification of loci and pathways associated with T2D-independent components of GDM, using FinnGen GWAS summary statistics for both GDM and T2D. Scientifically, it clarifies distinct genetic contributions to GDM beyond shared T2D biology, which may refine etiologic understanding and risk prediction.

Yang S, Xiao X, Yang Y et al. · Alzheimer’s research & therapy · (2026) · View on PubMed ↗ · Free PDF ↗

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Microbiome & diet–microbe interactions (gut/vaginal/sepsis)

Dietary patterns supportive of gut microbiota and bacterial vaginosis: A cross-sectional analysis from NHANES 2001 to 2004.

This cross-sectional NHANES 2001–2004 analysis studied associations between a literature-based dietary index supporting gut microbiota (DI-GM) and bacterial vaginosis (BV) prevalence in 1169 nonpregnant US women aged 20–49 years. BV (Nugent score ≥7) was evaluated against DI-GM derived from 14 beneficial versus non-beneficial food groups using dietary intake from two 24-hour recalls. The findings may link diet patterns that support gut microbiota to BV risk, suggesting potential dietary targets for BV prevention or risk reduction.

Zeng J, Ding Z, Dai Z · Medicine · (2026) · View on PubMed ↗ · Free PDF ↗

Effects of fecal microbiota transplantation and probiotics on the gut microbiome in antibiotic-treated septic patients: A pilot randomized controlled trial.

This pilot randomized controlled trial studied fecal microbiota transplantation (FMT) versus probiotics on gut microbiome restoration and inflammatory markers in 40 critically ill, antibiotic-treated sepsis patients. The key finding was the trial’s feasibility and exploratory comparison of microbiome and inflammatory outcomes across control (antibiotics only), probiotics, and FMT arms. Clinically, it informs whether microbiome-directed therapies could mitigate antibiotic-associated dysbiosis in sepsis and supports larger efficacy trials.

Chen Y, Zhao J, Zhao J et al. · Virulence · (2026) · View on PubMed ↗ · Free PDF ↗

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Immunology & immune evasion (cancer/autoimmunity/inflammation)

Obesity suppresses neutrophil-dependent itaconate signaling promoting ferroptosis in acute pancreatitis.

Researchers studied how obesity alters immune-metabolic signaling in acute pancreatitis by focusing on neutrophil-dependent itaconate signaling and its impact on ferroptosis in pancreatic inflammation. They found that myeloid cells are the principal source of itaconate, which is transferred via the SLC13A3 transporter to protect pancreatic acinar cells from ferroptosis through NRF2-dependent antioxidant responses, and that obesity suppresses this pathway. This identifies a neutrophil–SLC13A3–itaconate–NRF2 axis as a driver of ferroptosis susceptibility in acute pancreatitis and provides a mechanistic explanation for obesity-associated disease severity.

Jiménez-Cañete N, Aliena-Valero A, Bressan CA et al. · Redox biology · (2026) · View on PubMed ↗

Real-World Safety and Retention of Tofacitinib in Elderly Versus Non-elderly Patients With Rheumatoid Arthritis: A Retrospective Cohort Study in Taiwan.

A retrospective cohort study in Taiwan analyzed real-world tofacitinib treatment in rheumatoid arthritis patients to compare drug retention between elderly (≥65 years) and nonelderly (<65 years) groups and to identify factors associated with discontinuation. The study followed RA patients treated with tofacitinib from 2015–2020 with follow-up through December 31, 2021, and contrasted retention/discontinuation patterns between the two age strata (full results truncated). This provides practical, age-stratified evidence to guide tofacitinib persistence and discontinuation risk assessment in routine RA care.

Chiang LH, Tsai PH, Chen YF et al. · International journal of rheumatic diseases · (2026) · View on PubMed ↗

Microbiota-derived butyrate inhibits colonic epithelial pyroptosis and mitigates DSS-induced colitis via interacting with aryl hydrocarbon receptor.

This study tested whether microbiota-derived butyrate inhibits colonic epithelial pyroptosis and mitigates DSS-induced colitis through aryl hydrocarbon receptor (AhR) signaling, using DSS-treated mice, 16S rDNA sequencing and LC–MS/MS metabolomics, and LPS+ATP–induced pyroptosis in colonic epithelial (FHC) cells. Butyrate reduced colonic epithelial pyroptosis and improved DSS colitis outcomes, and these protective effects depended on AhR signaling, with GSDMD knockout used to support a pyroptosis-specific mechanism. The results suggest a therapeutic pathway for ulcerative colitis that targets epithelial pyroptosis via the butyrate–AhR axis.

Zou F, Wu Z, Wang S et al. · Journal of translational medicine · (2026) · View on PubMed ↗ · Free PDF ↗

Drug-induced psoriasis following sacubitril/valsartan: a case report and literature review.

This case report and literature review described a middle-aged male who developed psoriasis after treatment with sacubitril/valsartan (SV) for cardiovascular disease. The key clinical finding was the emergence of well-demarcated erythematous/violaceous, scaly plaques temporally associated with SV exposure and diagnosed as psoriasis. The report highlights SV as a potential trigger for drug-induced psoriasis and supports clinician awareness and monitoring for cutaneous adverse effects.

Tang T, Guo M, Yu H et al. · BMC cardiovascular disorders · (2026) · View on PubMed ↗ · Free PDF ↗

Lactic acid induces dendritic cell pyroptosis through MCT-1 to promote tumor immune evasion.

This study examined how lactic acid in the tumor microenvironment induces dendritic cell pyroptosis and promotes tumor immune evasion, using bone marrow–derived dendritic cells (BMDCs) and mechanistic assays. Lactic acid triggered dose-dependent pyroptosis via GSDMD cleavage through an MCT1-mediated K+/NLRP3/GSDMD axis, and inhibiting MCT1 reduced lactic acid–induced pyroptosis and immune evasion. The findings identify the MCT1–NLRP3–GSDMD pathway as a potential therapeutic target to restore dendritic cell–mediated antitumor immunity.

Yang S, Lin L, Zheng X et al. · Oncogene · (2026) · View on PubMed ↗

Deep phenotyping of skin tissue remodeling in patients with systemic sclerosis treated with CD19-CAR T cells.

This study deep-phenotyped skin tissue remodeling in systemic sclerosis (SSc) patients treated with CD19-CAR T cells using patient biopsy samples from the CASTLE study and named-patient use. Histology showed structural regeneration of SSc skin, including recovery of skin papillae, consistent with molecular changes detected by cyclic in situ hybridization (as reported in the abstract). The results support the concept that CD19-CAR T therapy can induce regenerative remodeling in otherwise hard-to-reverse fibrotic skin.

Rius Rigau A, Xu M, Liu Z et al. · Nature communications · (2026) · View on PubMed ↗ · Free PDF ↗

PD-1 regulates latent effector differentiation of thymic cytotoxic CD8+ T cells.

This study examined how thymic single-positive CD8+ T cells acquire latent effector differentiation and how programmed cell death protein 1 (PD-1) regulates this process in the context of thymic selection. The authors found that thymic SP CD8+ T cells undergo latent effector differentiation after selection, and that PD-1 constrains this differentiation program. These findings support a mechanism by which thymic output of PD-1–regulated effector-primed CD8+ T cells could shape durable anti-tumor immunity.

Mao Z, Hirdler JB, Gicobi JK et al. · Nature communications · (2026) · View on PubMed ↗ · Free PDF ↗

Kynurenine pathway impact on immune evasion and inflammation in acute myeloid leukemia.

This review summarized how the kynurenine pathway (KP) drives immune evasion and inflammation in acute myeloid leukemia (AML) through tryptophan catabolism. It describes that leukemic blasts overexpress IDO1 and TDO2, increasing L-kynurenine, which activates the aryl hydrocarbon receptor (AhR) to induce IL-6 and STAT3 phosphorylation with NF-κB co-activation while also promoting immunosuppression via FoxP3+ regulatory T-cell skewing and T/NK exhaustion and impaired dendritic and B-cell function. The significance is that KP components (e.g., IDO1/TDO2/AhR signaling) represent actionable targets to counter AML-associated immune dysfunction.

Wawrzak-Pienkowska K, Golonko A, Ignatiuk D et al. · Life sciences · (2026) · View on PubMed ↗ · Free PDF ↗

Biomarker-Guided Strategies for Tumor Vasculature: From Imaging Advances to Novel Therapeutic Interventions.

This review studied how molecular and imaging biomarkers of tumor vasculature—shaped by heterogeneous tumor microenvironment (TME) vascular architecture and signaling such as hypoxia-inducible factor 1 (HIF1)—can guide therapeutic interventions. The key finding is that vascular structural/functional abnormalities (e.g., permeability, endothelial phenotype, and impaired drug delivery) and angiogenic pathways can be leveraged to predict treatment response and outcomes. Scientifically, it links biomarker-driven imaging of tumor vessels to novel anti-vascular and combination strategies.

Purcell C, Ryspayeva D, Gopal J et al. · Cancer letters · (2026) · View on PubMed ↗ · Free PDF ↗

Therapeutic Efficacy and Antigenicity of a Novel PEGylated IgA Protease in Preclinical Models of IgA Nephropathy.

This preclinical study evaluated a novel PEGylated IgA protease derived from Thomasclavelia ramosa (strain AK183) in models of IgA nephropathy to test whether established glomerular IgA deposits can be cleared. The key finding was that the recombinant PEGylated enzyme promoted clearance of glomerular IgA deposits and improved histology toward normal. Scientifically and therapeutically, it supports direct enzymatic removal of pathogenic IgA as a potential strategy beyond targeting IgA production or downstream inflammation.

Shen X, Shu C, Dong Y et al. · Kidney international · (2026) · View on PubMed ↗

Targeting TNFR1 by salvianolic acid B alleviates sepsis-induced acute lung injury and pulmonary-intestinal epithelial barrier damage.

This study investigated salvianolic acid B (Sal B) as a host-directed therapy in sepsis-induced acute lung injury and pulmonary-intestinal epithelial barrier damage, focusing on TNFR1 signaling. The key finding was that Sal B alleviated septic ALI and barrier injury by targeting TNFR1 and thereby inhibiting NF-κB, necroptosis, and the p-MLCK/p-MLC2 pathway. Clinically, it supports Sal B as a potential TNFR1-centered therapeutic candidate to reduce multi-organ inflammatory injury in sepsis.

Ma L, Liu F, Shen J et al. · Phytomedicine : international journal of phytotherapy and phytopharmacology · (2026) · View on PubMed ↗ · Free PDF ↗

Identification of the critical immune-related drivers shared by non-alcoholic fatty liver disease and osteoporosis.

This study used Mendelian randomization and transcriptomic analyses to identify shared immune-related drivers of non-alcoholic fatty liver disease (NAFLD) and osteoporosis (OP) by integrating 731 immune cell traits and 91 circulating inflammatory proteins with gene expression datasets. It pinpointed immune factors and pathways that were consistently associated with both diseases and supported mechanistic links via differential expression and functional enrichment. These shared immune drivers provide candidate targets for therapies aimed at preventing or treating comorbid NAFLD and OP.

Chang F, Ge S, Zhang M et al. · Cellular and molecular life sciences : CMLS · (2026) · View on PubMed ↗ · Free PDF ↗

Loss of Ribosomal Protein RPL22 Restricts African Swine Fever Virus Replication by Inducing PERK-Dependent ER Stress.

This study investigated how loss of the ribosomal protein RPL22 affects African swine fever virus replication in domestic pigs and related experimental systems by inducing PERK-dependent ER stress. The key finding was that RPL22 restriction limited ASFV replication through activation of the PERK ER-stress pathway. Scientifically, it identifies a host translational/ER-stress vulnerability that could be exploited for antiviral strategies against ASFV.

Li P, Liao Z, Cao H et al. · Emerging microbes & infections · (2026) · View on PubMed ↗ · Free PDF ↗

Reprogramming the Immune Landscape of Inflammatory Breast Cancer.

This article reviewed and integrated evidence on how inflammatory breast cancer (IBC) reprograms the tumor microenvironment (TME) to promote immune evasion and therapeutic resistance. It highlights mechanisms including cytokine signaling loops, immune checkpoint overexpression, and tumor emboli that shield cancer cells from immune surveillance, supported by multi-omics and spatial transcriptomic findings. The scientific significance lies in identifying actionable immune landscape features that could guide new immunotherapeutic strategies for IBC.

Martinez-Rodriguez V, Ogata S, Wang X et al. · Advanced science (Weinheim, Baden-Wurttemberg, Germany) · (2026) · View on PubMed ↗ · Free PDF ↗

Post COVID-19 treated with AstraZeneca vaccine exacerbates arthritis with susceptibility to herpes in an older woman: A case report.

This case report described an older woman who developed worsening arthritis and susceptibility to herpes after COVID-19 infection or AstraZeneca vaccination. Despite treatment for rheumatoid arthritis symptoms, herpes, and mental health complaints, her condition did not improve. The report highlights a rare post-COVID/post-vaccination clinical scenario that may be relevant for clinicians monitoring older patients with autoimmune disease for herpes reactivation or flare-ups.

Guzman DC, Brizuela NO, Herrera MO et al. · Medicine · (2026) · View on PubMed ↗ · Free PDF ↗

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Cancer therapeutics & resistance (drug mechanisms, targets, trials)

RNF19A::PLAG1-rearranged uterine mesenchymal tumor with myofibroblastic features and focal adipocytic differentiation: broadening the histologic and molecular genetic spectrum of PLAG1-rearranged uterine mesenchymal neoplasms.

A 50-year-old woman was studied for a rare uterine mesenchymal tumor with PLAG1 rearrangement, assessed by histopathology and immunohistochemistry. The tumor showed bland spindle-to-epithelioid cells in solid sheets/fascicles with predominantly fibrous stroma, low mitotic activity, no necrosis, and focal mature adipocytes, with tumor cells co-expressing CD34, desmin, estrogen receptor, and progesterone receptor while retaining RB1 expression. This expands the histologic and molecular spectrum of PLAG1-rearranged uterine mesenchymal neoplasms beyond typical myxoid leiomyosarcoma patterns and supports broader diagnostic consideration of adipocytic/myofibroblastic features in PLAG1-rearranged disease.

Yin X, Wang H, Xu J et al. · Virchows Archiv : an international journal of pathology · (2026) · View on PubMed ↗

Fructose 1-phosphate inhibits mannose phosphate isomerase to suppress hepatocellular carcinogenesis.

The study examined how fructose metabolism affects hepatocellular carcinoma (HCC) by testing fructose 1-phosphate (F1P)–mediated effects on mannose phosphate isomerase (MPI) in the setting of fructolytic enzyme loss, particularly ALDOB deficiency. F1P inhibited MPI and suppressed hepatocellular carcinogenesis when ALDOB was deficient, supported by transcriptomic and metabolomic analyses (details truncated in the abstract). This mechanistically links ALDOB loss to a vulnerability in HCC metabolism and suggests MPI as a potential therapeutic or biomarker-relevant node in fructose/F1P-driven tumor suppression.

Wang Y, Zhang X, Wang N et al. · Signal transduction and targeted therapy · (2026) · View on PubMed ↗

ZNF831 suppresses triple-negative breast cancer progression through NLRP3-associated pyroptotic signaling and M1-like macrophage phenotypic remodeling.

This study investigated whether zinc finger protein 831 (ZNF831) suppresses triple-negative breast cancer (TNBC) progression by regulating NLRP3-associated pyroptosis and remodeling macrophage phenotypes, using integrated TCGA-BRCA and GEO bulk transcriptomic analyses plus functional validation in TNBC models. ZNF831 was found to enhance NLRP3-related pyroptotic signaling and drive M1-like macrophage phenotypic remodeling, correlating with reduced TNBC progression. The work supports a mechanistic link between ZNF831 and NLRP3-driven innate immune activation that could inform immunotherapy or target selection in TNBC.

Liu Q, Fan J, Peng W et al. · Breast cancer research : BCR · (2026) · View on PubMed ↗ · Free PDF ↗

An oncostatin M receptor and chloride intracellular channel 1 crosstalk drives key oncogenic pathways in glioblastoma.

This study investigated how oncostatin M receptor (OSMR) and chloride intracellular channel 1 (CLIC1) interact to drive oncogenic signaling in glioblastoma (GB), including therapy resistance in brain tumor stem cells. Using Mammalian Membrane Two-Hybrid High-Throughput Screening (MaMTH-HTS) to map the OSMR interactome, the authors identified OSMR crosstalk mechanisms that feed forward with EGFRvIII and STAT3 and also promote BTSC respiration and resistance. These findings position the OSMR–CLIC1 axis as a mechanistic driver of GB progression and a potential therapeutic target to overcome resistance.

Mansourabadi AH, Qu D, Cianci F et al. · Signal transduction and targeted therapy · (2026) · View on PubMed ↗ · Free PDF ↗

RBM20 isoform regulation by independent transcription start sites adapts alternative splicing in development and disease.

This study examined how RBM20 isoform production is controlled by independent transcription start sites and how this regulates alternative splicing during development and in disease, focusing on the cardiac splicing regulator RBM20. It identified a previously unrecognized transcription start site between exon 1 and exon 2 that generates a shorter, functional RBM20 isoform translated from an internal ATG in exon 2, with isoform ratios tightly regulated perinatally but selectively altered in hypertrophic cardiomyopathy. The work links transcriptional start-site choice to RBM20 splicing activity and suggests a splicing-regulatory mechanism that could be exploited for cardiac disease.

Radke MH, Badillo Lisakowski V, Meinke S et al. · Nature communications · (2026) · View on PubMed ↗ · Free PDF ↗

ZNF274 constrains lineage plasticity and drives intrinsic resistance to CDK7 inhibitors in pancreatic cancer.

This study tested how the KRAB-ZNF transcription factor ZNF274 regulates lineage plasticity and intrinsic resistance to CDK7 inhibitors in pancreatic ductal adenocarcinoma (PDAC). It found that ZNF274 maintains heterochromatin and suppresses genes including ZEB1, and that ZNF274 loss drives a classical-to-basal transition with mesenchymal features and increased susceptibility to CDK7 inhibition. Clinically, targeting the ZNF274–ZEB1 axis may help predict or overcome resistance to CDK7 inhibitors in PDAC.

Gianopulos JE, Schutter A, Dobersch S et al. · Nature communications · (2026) · View on PubMed ↗ · Free PDF ↗

Radioligand Therapy Hormone Combinations and the ENZA-p Trial.

This article reviewed the rationale for combining androgen-axis therapies with prostate-specific membrane antigen (PSMA) radioligand therapy in metastatic castration-resistant prostate cancer (mCRPC), focusing on the ENZA-p trial. It highlights preclinical and clinical evidence that androgen receptor signaling and PSMA receptor biology are linked, implying that hormone combinations can modulate PSMA-target availability and treatment response. The scientific significance is improved treatment design for PSMA radioligand therapy by optimizing androgen–PSMA inter-receptor interactions to enhance outcomes.

Emmett L · European urology focus · (2026) · View on PubMed ↗

Pharmacological targeting of the TLR8/AP-1 axis ameliorates scleroderma skin inflammation and fibrosis by suppressing monocyte-mediated endothelial injury.

This study tested whether pharmacologically targeting the Toll-like receptor 8 (TLR8)/AP-1 axis can reduce systemic sclerosis (SSc) skin inflammation and fibrosis by limiting monocyte-mediated endothelial injury. In SSc patient PBMCs and single-cell RNA-seq analyses, the authors used the TLR8 agonist VTX-2337 and AP-1 inhibition in co-culture experiments of CD14+ monocytes with human dermal microvascular endothelial cells to show that suppressing the TLR8/AP-1 pathway ameliorated inflammatory and injurious signaling. These results support the TLR8/AP-1 axis as a mechanistic therapeutic target for SSc.

Kong X, Hu M, Tan Q et al. · Life sciences · (2026) · View on PubMed ↗

Arginine restriction exploits DNMT3B-ASS1-driven arginine auxotrophy and mTORC1-suppressed autophagy to overcome niraparib resistance in ovarian cancer.

This study investigated mechanisms of acquired niraparib resistance in epithelial ovarian cancer using paired parental and niraparib-resistant models with integrated multi-omic and functional assays. The key finding was that DNMT3B-dependent promoter hypermethylation silenced argininosuccinate synthase 1 (ASS1), creating arginine auxotrophy that was exploited by arginine restriction while mTORC1-suppressed autophagy contributed to the resistant phenotype. Clinically, it suggests a biomarker-defined vulnerability (DNMT3B–ASS1 axis) to overcome PARP-inhibitor resistance in ovarian cancer.

Wang H, Wang X, Zhang W et al. · Cancer letters · (2026) · View on PubMed ↗ · Free PDF ↗

Targeted degradation of SETDB1 by an Aptamer-CRBNL PROTAC as a novel therapeutic strategy for breast cancer.

This work studied targeted protein degradation of SETDB1 in breast cancer using an aptamer-CRBNL PROTAC (P-SETDB1-4) that recruits the CRBN E3 ligase. The key finding was that the serum-stable aptamer-CRBNL PROTAC effectively recruited SETDB1 to the ubiquitin-proteasome system, leading to SETDB1 degradation and anti-tumor effects in preclinical settings. Scientifically, it demonstrates a programmable epigenetic target strategy using aptamer recognition plus PROTAC-mediated degradation.

Huang S, Lv Y, Wang Y et al. · European journal of medicinal chemistry · (2026) · View on PubMed ↗

First-Line Pembrolizumab Plus Chemotherapy for Advanced Biliary Tract Cancer: China Subgroup Analysis of the Randomized Phase 3 KEYNOTE-966 Study.

This China subgroup analysis of the randomized phase 3 KEYNOTE-966 trial studied pembrolizumab plus gemcitabine and cisplatin versus placebo plus gemcitabine and cisplatin in adults with previously untreated advanced biliary tract cancer enrolled in China. The pembrolizumab regimen improved overall survival relative to placebo without introducing new safety concerns in the Chinese participants. These results support pembrolizumab-based first-line therapy as a clinically meaningful option for advanced BTC in this population.

Ren Z, Liang T, Gu S et al. · Advances in therapy · (2026) · View on PubMed ↗

FARP1 Mediates cMET-Driven Motility in Androgen-Independent Prostate Cancer Cells.

This mechanistic study investigated how FARP1 regulates cMET-driven motility in androgen-independent prostate cancer cells, focusing on Rac1-dependent actin-rich protrusion formation. The work identifies FARP1 as a mediator of cMET signaling to Rac1-driven motility, linking a specific Rac-GEF pathway to metastatic behavior in androgen-independent prostate cancer models. The significance is that FARP1-cMET-Rac1 signaling may represent a tractable molecular target to limit invasion and progression in advanced prostate cancer.

Robayo P, Kazanietz MG, Baker MJ et al. · Endocrinology · (2026) · View on PubMed ↗

The t(X;5)(q13;q33) Translocation in Myeloid Neoplasms Is Preferentially Associated With Chronic Myelomonocytic Leukemia: A Report From the Groupe Francophone de Cytogénétique Hématologique.

This cytogenetic study characterized the rare t(X;5)(q13;q33) translocation in myeloid neoplasms and assessed its association with chronic myelomonocytic leukemia (CMML) in a Groupe Francophone de Cytogénétique Hématologique case series. It found that t(X;5) occurred preferentially in CMML (4/6 cases, 67%), often as an isolated abnormality, and may have functional consequences similar to del(5q) despite different karyotypic patterns. The clinical significance is that recognizing t(X;5) can refine CMML subgrouping and improve prognostic and diagnostic interpretation of cytogenetic findings.

Nguyen-Khac F, Muller M, Daudignon A et al. · Genes, chromosomes & cancer · (2026) · View on PubMed ↗

Outcomes of Patients With Hepatocellular Carcinoma Treated With Durvalumab Plus Tremelimumab in Real-World Clinical Practice Who Met or Did Not Meet the Inclusion Criteria for the Phase 3 HIMALAYA Trial.

This real-world cohort study evaluated outcomes in 412 patients with unresectable hepatocellular carcinoma treated with durvalumab plus tremelimumab (Dur/Tre) at 30 Japanese institutions, stratifying patients by whether they met the phase 3 HIMALAYA trial inclusion criteria. The key finding was that progression-free survival was longer in the HIMALAYA-eligible group (median 5.4 months) than in the non-eligible group (median 3.0 months), with statistical significance reported in the abstract. Clinically, it indicates that real-world effectiveness of Dur/Tre is influenced by trial-eligibility characteristics, supporting more precise patient selection for immunotherapy in HCC.

Matono T, Tada T, Hiraoka A et al. · Journal of gastroenterology and hepatology · (2026) · View on PubMed ↗

Cytokine receptor and JAK/STAT pathway mutations in acute myeloid leukemia: Prevalence and clinical impact.

This retrospective analysis studied the prevalence and clinical impact of cytokine receptor and JAK/STAT pathway mutations in 971 adults with newly diagnosed acute myeloid leukemia (AML) treated at the Cleveland Clinic (2015–2023). It found that mutations in eight Cy-JAK/STAT genes (CALR, JAK1, JAK2, JAK3, MPL, SH2B3, STAT3, STAT5B) were present at measurable rates and had prognostic associations depending on disease context/ontogeny (reported in the full text). The significance is that Cy-JAK/STAT mutational profiling could refine risk stratification and potentially guide targeted therapeutic strategies in AML.

Albliwi M, Nurse DP, Zabor EC et al. · Cancer · (2026) · View on PubMed ↗ · Free PDF ↗

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Cancer diagnostics & predictive modeling (imaging/radiomics/genomics)

Single-cell multi-omic integration analysis prioritizes druggable genes and reveals cell-type-specific causal effects in glioblastomagenesis.

The study integrated glioblastoma GWAS with bulk tissue and single-cell multi-omics to prioritize genetically supported druggable genes and to infer cell-type-specific causal effects in glioblastomagenesis. Using single-cell multi-omic integration and GWAS-supported prioritization methods (details truncated), it identified candidate druggable genes and mapped mechanisms to specific cell types relevant to GBM development. This provides a framework for translating genetic risk into cell-type–resolved therapeutic hypotheses for glioblastoma.

Huang YF, Wang KL · Journal of translational medicine · (2026) · View on PubMed ↗ · Free PDF ↗

Longitudinal Plasma Proteomics Reveals an Immuno-thrombotic Signature that Predicts Radiation Pneumonitis in Lung Cancer.

This prospective study used high-throughput longitudinal plasma proteomics to identify an immuno-thrombotic protein signature predicting radiation pneumonitis (RP) in lung cancer patients. In a discovery cohort of 57 patients with 267 longitudinal plasma samples, the authors applied rigorous feature selection within a 70% training partition and used statistical modeling (including linear mixed-effects models and weighted gene co-expression network approaches) to derive a blood-based risk signature. Clinically, the resulting proteomic predictor aims to enable earlier and more accurate RP risk stratification than static clinical or dosimetric measures.

Lingyun W, Nakamura M, Toru M et al. · International journal of radiation oncology, biology, physics · (2026) · View on PubMed ↗

An interpretable 1⁸F-PSMA PET/CT-MRI model for optimizing prostate biopsy decisions.

This multicenter retrospective study developed and externally validated an interpretable multimodal model in 302 biopsy-naïve men using 18F-PSMA PET/CT radiomics, mpMRI radiomics, and clinical variables to predict clinically significant prostate cancer and guide biopsy decisions. The model achieved improved discrimination for clinically significant prostate cancer compared with less integrated approaches and was designed to be decision-supportive rather than a black box. Clinically, it aims to reduce unnecessary biopsies by better stratifying biopsy-naïve patients for targeted sampling.

Xiong S, Ma J, Li H et al. · European journal of nuclear medicine and molecular imaging · (2026) · View on PubMed ↗

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Lysosomal storage & rare genetic diseases (diagnosis/monitoring/treatment)

Long-term comparative analysis of AAV9-mediated gene replacement therapies for spinal muscular atrophy in mice.

This study compared long-term efficacy and safety of AAV9-mediated SMN1 gene replacement strategies in mouse models of spinal muscular atrophy (SMA), including a Zolgensma-like benchmark vector versus a 2nd-generation vector. In SMA mice, intracerebroventricular delivery of the 2nd-generation codon-optimized SMN1 transgene under an endogenous SMN1 promoter improved survival and phenotypes, but in wild-type mice the 2nd-generation vector caused motor impairment 20 months post-injection. The findings highlight long-term safety considerations for SMN1 AAV gene replacement designs, especially regarding promoter/transgene expression in non-SMA hosts.

Chen X, Xie Q, Nath SJ et al. · Nature communications · (2026) · View on PubMed ↗ · Free PDF ↗

Quantification of Specific Urinary Oligosaccharide Biomarkers for Diagnosis and Treatment Monitoring of Alpha-Mannosidosis.

This study developed and evaluated a rapid, derivatization-free quantitative urinary assay for alpha-mannosidosis (AM) biomarkers GlcNAc(Man)2, GlcNAc(Man)3, and GlcNAc(Man)4 to support diagnosis and treatment monitoring. It addresses limitations of prior qualitative or semi-quantitative methods by enabling more precise longitudinal measurement of accumulated oligosaccharides in urine. The clinical significance is improved monitoring of therapeutic response in this ultra-rare lysosomal storage disorder, where early diagnosis and outcome tracking are critical.

Dörfel D, Dreyer B, Lindschau M et al. · Journal of inherited metabolic disease · (2026) · View on PubMed ↗ · Free PDF ↗

Mapping Clinical Progression to Brain Atrophy in CLN2 Patients Under Cerliponase Alfa Treatment: A Prospective Neuroimaging Study.

This prospective neuroimaging study in 27 CLN2 patients receiving intraventricular enzyme therapy (cerliponase alfa) mapped clinical progression to brain atrophy using longitudinal MRI. It modeled changes in cortical thickness and subcortical volumes with linear mixed-effects regression across 170 timepoints and assessed associations with detailed biannual clinical phenotyping. The significance is that it links lysosomal disease progression to measurable neurodegeneration trajectories under treatment, potentially improving outcome assessment in CLN2.

Petersen M, Westermann LM, Hagenah L et al. · Journal of inherited metabolic disease · (2026) · View on PubMed ↗ · Free PDF ↗

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Musculoskeletal/bone & mechanobiology (bone remodeling, osteoarthritis/periodontitis)

Macrophage piezo1 senses mechanical force to drive osteoclastogenesis via ZBP1: Implications for bone remodelling therapy.

The study investigated how macrophages sense mechanical force during orthodontic tooth movement (OTM) and drive osteoclastogenesis, using human periodontal ligament (PDL) tissues plus murine OTM and fracture models with macrophage-specific knockouts of Piezo1 and Zbp1 (Piezo1cko and Zbp1cko). It found that macrophage Piezo1 detects mechanical stress and signals through ZBP1 to promote osteoclastogenesis, and that disrupting either Piezo1 or Zbp1 reduces osteoclastogenic responses relevant to alveolar bone remodeling. These findings identify the Piezo1–ZBP1 mechanotransduction axis as a potential therapeutic target to improve bone remodeling and reduce root resorption risk during orthodontic treatment.

Zhu L, Zhang K, Song A et al. · Clinical and translational medicine · (2026) · View on PubMed ↗ · Free PDF ↗

Nonsteroidal Anti-Inflammatory Drugs and the Risk of Periodontitis Among Adults With Osteoarthritis: A Target Trial Emulation.

This target trial emulation studied whether nonsteroidal anti-inflammatory drugs (NSAIDs) affect the 5-year risk of incident periodontitis in adults with osteoarthritis, comparing NSAID initiation versus acetaminophen using US electronic health records (1995–2019). The key finding was that NSAID use was associated with a different (reported in the full text) 5-year periodontitis risk compared with acetaminophen after adjustment via inverse probability weighting and pooled logistic regression. Clinically, the results help clarify whether long-term COX inhibition from NSAIDs meaningfully alters periodontal disease incidence in an at-risk adult population.

Leiva-Escobar I, Chennas AP, Alayash Z et al. · Journal of clinical periodontology · (2026) · View on PubMed ↗ · Free PDF ↗

Implant therapy in older patients: Prosthetic considerations and biomechanical implications for frailty/aging.

This narrative review synthesized evidence on implant therapy in older adults, focusing on prosthetic considerations and biomechanical implications in the context of frailty and aging. It highlights how age-related factors (frailty, comorbidities, polypharmacy, and cognitive decline) can alter biomechanical demands and influence implant survival and complication profiles, with attention to prosthetic/material design and peri-implant soft tissue management. The review supports tailoring implant prosthodontic planning to geriatric risk factors to improve outcomes in partially and completely edentulous older patients.

Yeh YT, Chiou LL, Yoon D et al. · Periodontology 2000 · (2026) · View on PubMed ↗ · Free PDF ↗

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Respiratory disease & pulmonary infection/allergy (asthma/COPD/RSV/H5N1)

Dairy cows infected with influenza A(H5N1) reveals low infectious dose and transmission barriers.

This study experimentally characterized infectious dose, exposure routes, and transmission barriers of influenza A(H5N1) in female lactating dairy cows using an H5N1 B3.13 genotype virus. Intramammary inoculation with as few as 10 TCID50 produced robust infection and high-titer milk shedding, yet the virus showed limited transmission via contaminated milking equipment and close contact despite low infectious dose. These findings refine risk assessments for dairy cattle and suggest that transmission barriers may be driven by factors beyond mere shedding magnitude.

Lee C, Tarbuck NN, Cochran HJ et al. · Nature communications · (2026) · 9 citations · View on PubMed ↗ · Free PDF ↗

Mast cells support lung eosinophil homeostasis and the acute innate immune response to respiratory syncytial virus.

This study investigated the role of mast cells in lung eosinophil homeostasis and early innate immune responses during respiratory syncytial virus (RSV) infection using Cpa3-Cre; Mcl-1fl/fl mice lacking mast cells. Mast cell deficiency led to higher viral loads, greater weight loss and lung damage early in RSV infection, reduced eosinophil recruitment, and increased inflammatory monocytes plus CXCL10, CCL4, and TNF. The results indicate mast cells are protective regulators of eosinophil-driven antiviral balance and acute lung inflammation.

Hebbandi Nanjundappa R, Liwski CR, Edgar A et al. · Nature communications · (2026) · View on PubMed ↗ · Free PDF ↗

Prevalence and Clinical Implications of Aspergillus fumigatus Sensitisation in Chronic Obstructive Pulmonary Disease.

This review summarized evidence on Aspergillus fumigatus sensitisation in chronic obstructive pulmonary disease (COPD) and its clinical implications. It reports that sensitised COPD patients tend to have more respiratory symptoms, more frequent exacerbations, and worse prognosis, with additional morbidity and mortality when allergic bronchopulmonary aspergillosis (ABPA) coexists. The significance is that Aspergillus sensitisation may represent a treatable COPD “trait” supporting more personalized management strategies.

Luo Y, Sun Y · Mycoses · (2026) · View on PubMed ↗ · Free PDF ↗

Mycobacterium avium complex pulmonary disease in rheumatoid arthritis-associated interstitial lung disease under non-biologic immunomodulatory therapy: A case report.

This case report studied Mycobacterium avium complex (MAC) pulmonary disease in a 78-year-old man with rheumatoid arthritis (RA)-associated interstitial lung disease (ILD) who was not receiving glucocorticoids or biological disease-modifying antirheumatic drugs (non-biologic immunomodulatory therapy only). The key finding was that MAC pulmonary disease developed despite the absence of conventional high-risk biologic or steroid immunosuppression, challenging typical risk stratification for RA patients. Clinically, it highlights that RA patients with ILD on non-biologic immunomodulators can still require MAC evaluation when respiratory symptoms progress.

Tang R, Wang R, Han Y · Medicine · (2026) · View on PubMed ↗ · Free PDF ↗

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Renal & urogenital injury/immune pathways

USAG-1 aggravates renal ischemia‒reperfusion injury via promoting GPX4 degradation-induced ferroptosis.

This study assessed whether uterine sensitization-associated gene-1 (USAG-1) contributes to ferroptosis in murine renal ischemia–reperfusion injury (IRI) and in human transplant kidney biopsies from donation after circulatory death donors. USAG-1 was upregulated under ischemic conditions and promoted GPX4 degradation, thereby driving ferroptosis and worsening renal IRI outcomes. Clinically, targeting the USAG-1–GPX4 axis may represent a strategy to reduce delayed graft function risk by limiting ferroptotic cell death.

Li X, Wang H, Ma H et al. · Cell death & disease · (2026) · View on PubMed ↗ · Free PDF ↗

Evidence and Consensus Based Guidelines in Vogt-Koyanagi-Harada Disease. Multimodal imaging in Uveitis (MUV) Taskforce Report 16.

This consensus guideline effort studied how multimodal imaging should be used by international uveitis and retina specialists to diagnose, stage disease activity, and detect complications in Vogt-Koyanagi-Harada (VKH) disease. The key outcome was an expert, evidence- and consensus-based framework recommending specific multimodal imaging approaches across active, resolved, and late-stage VKH. Clinically, it standardizes imaging workflows to improve VKH assessment and complication detection across centers.

Yang P, Xia L, Agarwal A et al. · Ophthalmology. Retina · (2026) · View on PubMed ↗ · Free PDF ↗

Nociceptive sensory nerves induce an IL4Rαhi anti-inflammatory macrophage subset that protects against kidney ischemia-reperfusion injury.

This study examined how TRPV1+ nociceptive sensory nerves regulate kidney immune responses during kidney ischemia-reperfusion injury using reporter mice and retrograde neuronal tracing. The key finding was that TRPV1+ sensory nerves induce an IL4Rα^hi anti-inflammatory macrophage subset that protects against kidney I/R injury. Clinically, it identifies a neuroimmune protective pathway that could be targeted to reduce acute kidney injury.

Zhang S, Pan X, Liu H et al. · Kidney international · (2026) · View on PubMed ↗

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Methodology, guidelines & research tools (consensus, software, trial emulation)

[Use of inhaled nitric oxide during neonatal transport - a review of seven years of experience].

This review evaluated the use of inhaled nitric oxide during neonatal transport over seven years of experience from Hungary’s Peter Cerny Foundation Neonatal Transport Service. It describes inhaled nitric oxide as an effective pulmonary vasodilator used during transport for persistent pulmonary hypertension of the newborn to support gas exchange until tertiary intensive care handover. Clinically, the synthesis supports feasibility and potential benefit of implementing inhaled nitric oxide in neonatal transport workflows for time-critical management of pulmonary hypertension.

Lantos L, Somogyvári Z, Széll A et al. · Orvosi hetilap · (2026) · View on PubMed ↗

How to make big data accessible to plant biologists and beyond: Ten years of lessons from TBtools.

This article reviewed and synthesized lessons from TBtools over ten years to explain how to make big data accessible to plant biologists and other life scientists. It describes TBtools as a software ecosystem designed to narrow the skills gap between experimental biologists and increasingly complex omics/big-data analyses, improving data exploration and evidence integration. Scientifically, it supports broader adoption of systems-level, data-driven plant biology workflows by lowering barriers to analyzing large-scale datasets.

Feng J, Chen C, Wu Y et al. · Molecular plant · (2026) · View on PubMed ↗ · Free PDF ↗

How I do it: Managing a Critically Ill Patient with Pulmonary Arterial Hypertension.

This “How I do it” article reviewed ICU-focused management strategies for critically ill patients with pulmonary arterial hypertension (PAH) who develop acute decompensated right ventricular failure (RVF). It emphasizes recognition and treatment of reversible precipitants in the ICU setting, given that superimposed acute illness in PAH commonly leads to RVF and high mortality. The clinical significance is practical guidance for stabilizing PAH patients during acute deterioration to reduce RVF-related deaths.

Sulica R, De Marco T, Bartolome S et al. · Chest · (2026) · View on PubMed ↗

RpS12-mediated induction of the Xrp1short isoform links ribosomal protein mutations to cell competition.

This study investigated how the ribosomal protein RpS12 regulates the Xrp1 transcription factor splice isoforms in the context of Drosophila cell competition, linking ribosomal protein mutations to loser-cell identity. RpS12 promoted production of the Xrp1short isoform, and RpS12 overexpression was sufficient to induce Xrp1short and confer loser status, while either Xrp1short or Xrp1long could trigger competition. Scientifically, it identifies RpS12→Xrp1 splicing as a mechanistic bridge between ribosomal dysfunction and cell competition, informing how translation-related mutations drive tissue-level selection.

Tsakiri E, Potiri M, Kontogiannidi K et al. · Cell reports · (2026) · View on PubMed ↗ · Free PDF ↗

Global Technical Variations in Roux-en-Y Gastric Bypass: A Worldwide Survey Among IFSO Members.

This worldwide cross-sectional survey assessed technical practice variations in Roux-en-Y gastric bypass among IFSO-affiliated surgeons, focusing on pouch configuration, intestinal limb lengths, and gastrojejunostomy techniques. The study found substantial global heterogeneity in key operative parameters and identified factors influencing intraoperative decision-making. Scientifically and clinically, mapping these variations can inform standardization efforts and future comparative studies to determine which technical choices optimize outcomes.

Hany M, Zidan MH, Altabbaa H et al. · Obesity surgery · (2026) · View on PubMed ↗ · Free PDF ↗

Criteria for Hidradenitis Suppurativa Competence Centers.

This Delphi consensus project studied 22 hidradenitis suppurativa (HS) experts (including patient representatives) to define criteria for HS Competence Centers (HSCC) using a structured multi-round agreement process. The resulting consensus established specific requirements for HSCC organization and capabilities, reaching predefined agreement thresholds across expert polling rounds. Implementing these criteria can improve access to multimodal HS care and standardize service quality across regions.

Marzano AV, Bechara FG, Shi VY et al. · Dermatology and therapy · (2026) · View on PubMed ↗ · Free PDF ↗

Associations Between Two-Year Immune-Related Adverse Events and Psychological Distress and Subsequent Survival Outcomes Among ICI-Treated Survivors Diagnosed With Advanced Cancers in the US.

This retrospective US EHR-derived cohort study examined associations between two-year immune-related adverse events (irAEs) and psychological distress (anxiety/depression) with subsequent overall survival among 8671 survivors of advanced cancers treated with immune-checkpoint inhibitors (ICIs). The key finding was that specific patterns of irAEs and psychological distress were associated with survival outcomes (details provided in the full text), using Kaplan–Meier and multivariable logistic regression analyses in R. The significance is that mental health and irAE burden may serve as clinically actionable prognostic factors in long-term ICI survivorship care.

Tay DL, Dubose K, Young A et al. · Psycho-oncology · (2026) · View on PubMed ↗ · Free PDF ↗

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Generated automatically on May 25, 2026 from PubMed’s trending articles. Summaries are AI-generated; always consult the original publication for clinical or research decisions.