PubMed Trending Research Digest — May 26, 2026

Automated digest · 97 articles · 15 research areas · May 26, 2026

Overview

This week’s digest is dominated by translational cancer research that links biomarkers to therapy selection and resistance. Multiple studies focus on improving how we detect or predict response using minimally invasive or scalable approaches—e.g., ddPCR-based KRAS genotyping from EUS-FNA cytology wash fluid, EV-based antibody sandwich assays predicting anti–PD-1 benefit, and a mutational-signature biomarker for HRD to guide olaparib maintenance. In parallel, mechanistic work continues to map how tumors evade therapy: lactic-acid–driven dendritic cell pyroptosis and immune evasion, mitochondrial biogenesis as an imipridone resistance route in diffuse midline glioma, and multiple tumor-intrinsic signaling axes (e.g., HDAC4–ferroptosis/radiotherapy resistance, SLC25A13–STAT3–IFI6 immune suppression) that suggest actionable vulnerabilities.

A second major theme is immune regulation across diseases—especially how microenvironments and immune cell states shape outcomes. Studies span tumor immunology (OPN–TGF-β1 suppression of NK cells in HNSCC; ZNF831-driven NLRP3 pyroptosis and macrophage remodeling in TNBC; SRGN–macrophage crosstalk in early LUAD) and inflammatory/microbiome mechanisms (butyrate/AhR control of epithelial pyroptosis in colitis; environmental microbiota inducing Tregs and protection from colitis/metabolic disease/sepsis). Neuroimmunology also appears repeatedly, including microglial signaling in VZV neuroinflammation and CKD-associated cognitive decline via Ccl4–Ccr5.

Finally, cardiovascular and metabolic risk management remains prominent, with evidence spanning lipid risk stratification (pediatric familial hypercholesterolemia consensus; residual risk from Lp(a) despite LDL goals; Lp(a) as a modifier of evolocumab benefit), long COVID–associated cardiovascular events, and cost-effectiveness of finerenone in HFmrEF/HFpEF. Complementing this, metabolic and endocrine interventions continue to be evaluated in diverse populations (semaglutide in schizophrenia spectrum disorders; tirzepatide in early type 2 diabetes; comparative SGLT2 vs DPP-4 effects on insulin sensitivity), while methodological and guideline papers provide tools to standardize diagnosis and measurement across clinical domains.

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Cancer diagnostics & liquid biopsy biomarkers

The crosslink between autophagy and ferroptosis in polycystic ovary syndrome: from synergistic pathogenesis to targeted therapy.

This review article synthesized evidence on how autophagy and ferroptosis interact in polycystic ovary syndrome (PCOS), focusing on ovarian granulosa cell (GC) dysfunction and follicular atresia/ovulatory failure. The key finding was the proposed synergistic micro-pathogenic network linking autophagy–ferroptosis crosstalk to specific pathological microenvironments in PCOS GCs, framing it as a basis for targeted therapy concepts. Scientifically, it consolidates mechanistic hypotheses and therapeutic directions aimed at modulating cell-death and quality-control pathways in PCOS.

Wu X, Li J, Zhang X et al. · Journal of ovarian research · (2026) · View on PubMed ↗ · Free PDF ↗

Mutational Signature-Based Biomarker for Phase II Trial of Olaparib Maintenance in Advanced High-Grade Ovarian Cancer.

This phase 2 trial developed and validated a mutational signature-based biomarker (MSBM) to define homologous recombination deficiency (HRD) for olaparib maintenance in newly diagnosed advanced high-grade ovarian cancer. In 170 patients with stage IIIC/IV disease, MSBM integrated three whole-exome sequencing-derived features (tumor BRCA mutation status, Mutational Signature 3 similarity score >0.5, or score >0.25 without CCNE1 amplification) to identify HRD-positive patients for olaparib maintenance efficacy assessment (58 HRD-positive patients responding [truncated]). If validated, MSBM could enable earlier and more practical HRD selection for olaparib by avoiding genomic scar-based assays.

Oda K, Shintani D, Nishijima A et al. · Cancer science · (2026) · View on PubMed ↗ · Free PDF ↗

Tumor-Derived Extracellular Vesicles in Plasma for Predicting Anti-PD-1 Antibody Efficacy in Non-Small Cell Lung Cancer.

This study developed plasma liquid-biopsy antibody-based sandwich assays to quantify extracellular vesicle (EV) subsets expressing cell surface vimentin (CSV) and co-expressing EpCAM or PD-L1, and tested whether baseline EV levels predict anti-PD-1 efficacy in non-small cell lung cancer (NSCLC). In 57 resected stage I NSCLC patients and 89 stage IV NSCLC patients treated with anti-PD-1 antibodies, baseline EpCAM/CSV-EV levels and related EV subset measurements were associated with clinicopathological features and treatment response. These findings support CSV/EpCAM- and CSV/PD-L1–positive EVs as potential predictive biomarkers for selecting patients likely to benefit from anti-PD-1 therapy.

Kinoshita T, Ohta S, Wakui S et al. · Cancer science · (2026) · View on PubMed ↗ · Free PDF ↗

Diagnostic performance of droplet digital PCR for KRAS mutation analysis in pancreatic cancer cytology specimens.

This study evaluated droplet digital PCR (ddPCR) for KRAS mutation detection in residual cytology wash fluid from endoscopic ultrasound–guided fine-needle aspiration (EUS-FNA) in 38 patients with pancreatic cancer, benchmarking ddPCR against next-generation sequencing (NGS) of tumor tissue. ddPCR detected KRAS mutations with a lower positivity threshold (0.1%) than tissue NGS (1.0%) and showed concordance between cytology-based ddPCR and tissue-based NGS. Rapid, tissue-sparing KRAS genotyping from cytology wash fluid could enable timely selection of patients for KRAS-targeted therapies when tissue is limited.

Umemoto K, Nakahara K, Ohike N et al. · Journal of gastroenterology · (2026) · View on PubMed ↗

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Cancer therapeutics & treatment response (systemic/locoregional)

An HDAC4-specific PROTAC degrader achieves radiation sensitization by enhancing ferroptosis in lung cancer.

This study examined how HDAC4 regulates ferroptosis and radiotherapy response in lung cancer, using CRISPR screening in patient-derived organoids and mechanistic assays of HDAC4-mediated post-translational modification. HDAC4 promoted radiation resistance by acting as an E3 SUMO ligase that SUMOylated MBD1, preventing MBD1 ubiquitination/degradation and thereby repressing TP53 and CYP1A1 transcription to suppress lipid ROS and ferroptosis; an HDAC4-specific PROTAC (TP1) enhanced radiation sensitization by restoring ferroptosis. These findings identify an HDAC4–MBD1–TP53/CYP1A1 axis as a therapeutic vulnerability and support PROTAC-mediated HDAC4 degradation as a strategy to improve lung cancer radiotherapy outcomes.

Cheng C, Sun L, Yang J et al. · Nature communications · (2026) · View on PubMed ↗

Efficacy of Cabozantinib in Patients With Advanced Renal Cell Carcinoma With Bone Metastasis Assessed by Modified MD Anderson Criteria: An Open-Label Phase 2 Study.

This open-label phase 2 study evaluated cabozantinib efficacy in adult Japanese patients with advanced renal cell carcinoma (aRCC) with bone metastasis, using a modified MD Anderson criteria to assess objective response rate (ORR) of bone target lesions. Cabozantinib produced measurable responses and disease control in bone lesions, with secondary outcomes including overall survival (OS) and progression-free survival (PFS). The results are clinically relevant for targeting bone metastases in aRCC and for validating response assessment using modified MD Anderson criteria.

Hongo F, Nakai Y, Nozawa M et al. · International journal of urology : official journal of the Japanese Urological Association · (2026) · View on PubMed ↗ · Free PDF ↗

A positive feedback loop between BACH1 and IL-1β promotes the progression of HPV-negative head and neck squamous cell carcinoma.

This study investigated the role of BTB Domain and CNC Homolog 1 (BACH1) in HPV-negative head and neck squamous cell carcinoma (HNSCC) progression. The key finding was that BACH1 is upregulated in HPV-negative HNSCC and promotes tumor progression by enhancing proliferation and inhibiting apoptosis, in part by associating with the SWI/SNF chromatin remodeling complex and transcriptionally activating IL1B. Clinically, identifying the BACH1–IL-1β axis as a driver of HPV-negative HNSCC progression suggests a potential therapeutic target to improve outcomes in this higher-risk subgroup.

Zhang Z, Wang M, Wang W et al. · Cell communication and signaling : CCS · (2026) · View on PubMed ↗ · Free PDF ↗

Macrophage exosome-modified Mn/Se nanoheterostructure induces post-infarction cardiomyocyte regeneration and immunometabolic microenvironment repair.

The study investigated a Mn/Se nanoheterostructure (PMS@ME) modified with macrophage-derived exosomes and polydopamine for post–myocardial infarction (MI) repair in a preclinical post-infarction cardiomyocyte regeneration context. The therapy promoted cardiomyocyte regeneration and repaired the immunometabolic microenvironment after MI. This supports a translational nanotherapeutic strategy that couples metal-based nanoheterostructures with macrophage exosome signaling to improve outcomes after MI.

Guo L, Xiong Z, Sheng K et al. · Journal of nanobiotechnology · (2026) · View on PubMed ↗ · Free PDF ↗

Real-life experience in the treatment of gallbladder carcinoma by transarterial radioembolization: a multicenter retrospective study.

This multicenter retrospective study evaluated transarterial radioembolization for gallbladder carcinoma with liver-dominant metastatic disease, using yttrium-90 or holmium-166 radioembolization across five tertiary centers. The key finding was that radioembolization achieved measurable tumor control with an acceptable safety profile in this rare metastatic population. Clinically, it supports radioembolization as a potential liver-directed option when systemic options are limited.

Dertnig T, Kloeckner R, Mueller L et al. · EJNMMI reports · (2026) · View on PubMed ↗ · Free PDF ↗

Single-nucleus profiling of postmortem diffuse midline gliomas identifies mitochondrial biogenesis as a resistance mechanism to imipridone therapy.

This study used single-nucleus RNA sequencing and open-chromatin sequencing on postmortem tissue from 22 diffuse midline glioma (DMG) cases treated with imipridones (including ONC201/imipridone) to identify resistance mechanisms, with additional myeloid phenotyping in 46 cases. The key finding was that mitochondrial biogenesis emerged as a tumor-intrinsic resistance mechanism to imipridone therapy. This is significant because it suggests mitochondrial pathways as actionable targets to overcome or prevent resistance to imipridones in H3K27-altered DMG.

Okada M, Subramaniam B, Geng B et al. · Neuro-oncology · (2026) · View on PubMed ↗ · Free PDF ↗

Fructose 1-phosphate inhibits mannose phosphate isomerase to suppress hepatocellular carcinogenesis.

The study examined how fructose suppresses hepatocellular carcinoma (HCC) in the setting of fructolytic enzyme loss, focusing on fructose-1-phosphate (F1P) inhibition of mannose phosphate isomerase (MPI) in ALDOB-deficient contexts. It found that fructose-derived F1P inhibits MPI to suppress hepatocellular carcinogenesis when ALDOB deficiency is present, supported by transcriptomic and metabolomic analyses (metabo[…]). This mechanistic link suggests a potential metabolic vulnerability in ALDOB-deficient HCC that could be exploited therapeutically.

Wang Y, Zhang X, Wang N et al. · Signal transduction and targeted therapy · (2026) · View on PubMed ↗ · Free PDF ↗

Multifunctional spatiotemporally programmed microneedle patches for the reconstruction of antibacterial and immunoregenerative homeostasis in periodontitis therapy.

The study developed multifunctional spatiotemporally programmed core-shell microneedle patches for periodontitis therapy, targeting antibacterial action and immunoregenerative homeostasis in a localized delivery system. The microneedles used a rapidly dissolvable hyaluronic acid backing layer for substrate detachment in saliva, and the needle structure combined a ZIF-8-loaded ROS-responsive PVA-TSPBA shell with a GelMA core encapsulating therapeutic cargo (GelMA core encapsulating [truncated]). This platform suggests a strategy to treat periodontitis by combining controlled ROS-responsive antibacterial effects with regenerative immunomodulation directly within gingival tissues.

Dong W, Wang L, Zhao Q et al. · Acta biomaterialia · (2026) · View on PubMed ↗

Efficacy of Upadacitinib in Patients with Atopic Dermatitis of the Head and Neck Region.

This post hoc analysis of Measure Up 1 (NCT03569293) and Measure Up 2 (NCT03607422) studied efficacy of upadacitinib versus placebo in patients with head and neck atopic dermatitis, including stratification by baseline head and neck EASI. At week 16, upadacitinib (15 mg and 30 mg) produced higher rates of stringent clearance targets (e.g., head/neck EASI ≤0.3, EASI 90/100) and improved patient-reported outcomes compared with placebo (full results truncated). The findings support upadacitinib as an effective targeted therapy for difficult-to-treat head and neck AD.

Eyerich K, Mendes-Bastos P, Holzer G et al. · Dermatology and therapy · (2026) · View on PubMed ↗ · Free PDF ↗

Real-world efficacy and safety of immune checkpoint blockades in advanced urothelial carcinoma with histologic variant subtypes: the pembroblad study.

This French multicenter retrospective study (pembroblad) examined real-world outcomes of immune checkpoint blockade in advanced urothelial carcinoma with histologic variant subtypes (UC-V) and non-urothelial carcinomas (NUC) after platinum progression. Patients received second-line anti–PD-(L)1 monotherapy between 2016 and 2022, and the study evaluated overall response and safety across these under-represented histologic variant groups (primary endpoint details truncated). The results are clinically important for guiding ICB use in aggressive bladder/urinary tract cancers that are poorly represented in randomized trials.

Amrane K, Campedel L, Moinard-Butot F et al. · Cancer immunology, immunotherapy : CII · (2026) · View on PubMed ↗ · Free PDF ↗

PSMC2 promotes hepatocellular carcinoma progression through interaction with EGFR.

This study examined the role of Proteasome 26S Subunit ATPase 2 (PSMC2) in hepatocellular carcinoma (HCC) progression and its interaction with EGFR using TCGA analyses, immunohistochemistry (IHC), Western blot, and HCC cell functional assays. PSMC2 was upregulated in HCC and promoted malignant phenotypes (proliferation, colony formation, migration, and invasion) while mechanistically interacting with EGFR to drive tumor progression. These findings suggest that the PSMC2–EGFR axis could be a therapeutic target or biomarker pathway for HCC.

Li Y, Su Q, Feng Z et al. · Clinical and experimental medicine · (2026) · View on PubMed ↗ · Free PDF ↗

Microglial MARCO facilitates Varicella zoster virus uptake and triggers TLR2-mediated neuroinflammation.

This study examined how varicella zoster virus (VZV) affects microglial morphodynamics and function in human microglial models (HMC3, HIM, and human embryonic stem cell–derived microglia) using wild-type VZV (YC01) and attenuated strains (MAV/06, MAV). VZV uptake was facilitated by microglial MARCO and triggered TLR2-mediated neuroinflammation, supported by bulk RNA sequencing. These findings identify the MARCO–TLR2 axis as a mechanistic driver of VZV-induced neuroinflammation and a potential therapeutic target to limit CNS damage during infection.

Lim JS, Oh SJ, Hur JY et al. · Journal of biomedical science · (2026) · View on PubMed ↗ · Free PDF ↗

Comparative fall risk of patients treated with novel androgen receptor antagonists in prostate cancer: a systematic review and meta-analysis.

This systematic review and meta-analysis evaluated fall risk in patients with prostate cancer treated with novel androgen receptor pathway inhibitors (enzalutamide, apalutamide, darolutamide) versus placebo or non-steroidal antiandrogens in Phase 2/3 randomized controlled trials. Across trials, the key outcome was risk ratios for all-grade and grade ≥3 falls, enabling drug-specific comparison of ARPI-associated fall risk. Clinically, the results support more informed selection and monitoring of ARPIs by quantifying which agents may carry higher fall risk in advanced prostate cancer.

Wei C, Cai Y, Huang Z et al. · BMC cancer · (2026) · View on PubMed ↗ · Free PDF ↗

Pulmonary toxocariasis presenting as migratory pulmonary infiltrates and mediastinal lymphadenopathy: a case report and literature review.

This case report and literature review described pulmonary toxocariasis in a 53-year-old female smoker presenting with migratory pulmonary infiltrates and mediastinal lymphadenopathy that mimicked lung cancer. Despite non-diagnostic bronchoscopy with EBUS-TBNA, the patient was treated empirically with dexamethasone for suspected organizing pneumonia, reflecting the diagnostic challenge of eosinophilic lung disease caused by Toxocara canis/cati. The report highlights the need to consider toxocariasis in the differential diagnosis of eosinophilic pulmonary presentations with malignancy-like imaging.

Ghasemi F, Khoshnam Rad N, Rashidinejad B et al. · BMC pulmonary medicine · (2026) · View on PubMed ↗ · Free PDF ↗

Association between preoperative quality of life (QoL) and postoperative complications after gastrectomy for gastric carcinoma.

This retrospective analysis assessed whether preoperative quality of life (QoL) predicts postoperative complications after gastrectomy for gastric carcinoma in 908 prospectively collected patients. Preoperative QoL was measured using EORTC QLQ-C30 and STO22, and multivariate logistic regression with ROC evaluation was used to build a predictive model. If validated, the work supports using baseline QoL instruments to stratify surgical risk and anticipate complication likelihood after gastrectomy.

Jang A, Jeong O · Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · (2026) · View on PubMed ↗

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Cancer immunology & tumor microenvironment

Osteopontin-driven TGF-β1 signaling via integrin αvβ3-NF-κB axis impairs NK cell function in head and neck squamous cell carcinoma.

The study investigated how osteopontin (OPN)-driven TGF-β1 signaling through the integrin αvβ3–NF-κB axis impairs natural killer (NK) cell function in head and neck squamous cell carcinoma (HNSCC). Using flow cytometry, multiplex immunohistochemistry, and RNA-seq analyses (bulk and single-cell), it found that OPN–integrin αvβ3/NF-κB signaling promotes TGF-β1 production that suppresses NK cell activity. Mechanistically, it identifies a tumor-immunosuppressive pathway that could be targeted to restore NK cell function in HNSCC.

Shen Z, Li X, Luo S et al. · Apoptosis : an international journal on programmed cell death · (2026) · View on PubMed ↗ · Free PDF ↗

Obesity suppresses neutrophil-dependent itaconate signaling promoting ferroptosis in acute pancreatitis.

This mechanistic study investigated how obesity alters neutrophil-dependent itaconate signaling to promote ferroptosis in acute pancreatitis, focusing on myeloid-derived itaconate delivery to pancreatic acinar cells. Obesity enhanced a pathway in which neutrophil/myeloid-derived itaconate, transferred via the SLC13A3 transporter, modulated NRF2-dependent antioxidant responses that protect against ferroptosis during pancreatic inflammation (with obesity disrupting protective regulation; details truncated). Scientifically, it defines an immunometabolic itaconate–SLC13A3–NRF2 axis as a potential therapeutic target to reduce ferroptosis-driven pancreatic injury in obese patients.

Jiménez-Cañete N, Aliena-Valero A, Bressan CA et al. · Redox biology · (2026) · View on PubMed ↗ · Free PDF ↗

ZNF831 suppresses triple-negative breast cancer progression through NLRP3-associated pyroptotic signaling and M1-like macrophage phenotypic remodeling.

This study investigated whether zinc finger protein 831 (ZNF831) suppresses triple-negative breast cancer (TNBC) progression by modulating NLR family pyrin domain containing 3 (NLRP3)-associated pyroptotic signaling and remodeling macrophage phenotypes, using integrated TCGA-BRCA and Gene Expression Omnibus bulk datasets plus mechanistic experiments. The key finding was that ZNF831 enhances NLRP3-linked pyroptosis and drives M1-like macrophage phenotypic remodeling, correlating with improved antitumor immune activity in TNBC. This provides a gene-level upstream regulator connecting pyroptosis to macrophage reprogramming, supporting ZNF831/NLRP3 pathways as potential immunotherapeutic targets in TNBC.

Liu Q, Fan J, Peng W et al. · Breast cancer research : BCR · (2026) · View on PubMed ↗ · Free PDF ↗

Vaccine-expanded plasmablast-like B cells are associated with response to dendritic cell therapy in metastatic melanoma.

This study analyzed vaccine-expanded plasmablast-like B cells within dendritic cell vaccine (DCVax) products and related immune features to determine associations with clinical response in patients with metastatic melanoma receiving monocyte-derived DC therapy. The key finding was that higher frequencies/abundance of vaccine-expanded plasmablast-like B cells were associated with responder status compared with non-responders. This suggests that plasmablast-like B-cell expansion in the DC vaccine product could serve as a predictive immune biomarker for DCVax efficacy in metastatic melanoma.

Tazzari M, Carloni S, Bulgarelli J et al. · Journal of experimental & clinical cancer research : CR · (2026) · View on PubMed ↗ · Free PDF ↗

Spatial and single-cell transcriptomic profiling reveals interplay between SRGN-associated epithelial programs and C1QC+ macrophages in early LUAD progression.

This study used integrated single-cell RNA sequencing (scRNA-seq) and spatial transcriptomics to map early lung adenocarcinoma (LUAD) progression and specifically examined the interplay between SRGN-associated epithelial programs and C1QC+ macrophages across stages from precursor lesions to invasive disease. The key finding was that SRGN-linked epithelial states co-evolve with C1QC+ macrophage programs, indicating coordinated epithelial–macrophage crosstalk during early LUAD progression. This provides a spatially resolved cellular mechanism that could inform early intervention strategies targeting SRGN–macrophage interactions in LUAD.

Mao S, Pang C, Hang H et al. · Journal of translational medicine · (2026) · View on PubMed ↗ · Free PDF ↗

Mast cell-specific receptor MrgprB2 selectively mediates oxaliplatin-induced neuropathic pain.

This study investigated in mice how mast cell-specific MrgprB2 signaling mediates oxaliplatin-induced chemotherapy-induced peripheral neuropathic pain, comparing oxaliplatin versus paclitaxel effects and focusing on the mast-cell receptor MrgprB2 (human orthologue MrgprX2). The key finding was that MrgprB2 selectively drives oxaliplatin-induced neuropathic pain behaviors, indicating receptor-specific mast-cell contributions to CIPN. This identifies MrgprB2 as a potential therapeutic target to prevent or treat oxaliplatin-associated neuropathy without necessarily affecting other chemotherapy-induced pain pathways.

Guan LC, Luo Z, Kothari R et al. · Journal of translational medicine · (2026) · View on PubMed ↗ · Free PDF ↗

Lactic acid induces dendritic cell pyroptosis through MCT-1 to promote tumor immune evasion.

This study investigated how lactic acid in the tumor microenvironment affects dendritic cell (DC) survival and function, using bone marrow-derived DCs (BMDCs) to model DC pyroptosis. Lactic acid induced dose-dependent pyroptosis via GSDMD cleavage through monocarboxylate transporter 1 (MCT1)-mediated signaling along the K+/NLRP3/GSDMD axis, promoting tumor immune evasion. Targeting MCT1 or the NLRP3/GSDMD pyroptotic pathway could restore DC-mediated anti-tumor immunity in lactic-acid–rich tumors.

Yang S, Lin L, Zheng X et al. · Oncogene · (2026) · View on PubMed ↗

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Cancer genomics, epigenomics & 3D genome regulation

Lipid clinics worldwide: harmonization and guidance on how to optimally organize and fund. European Atherosclerosis Society consensus statement across 55 countries and more than 500 lipid clinics.

The study used atomic force microscopy to examine the nanoscale structure of chromosomes preserved in liquid, focusing on filamentous components of mitotic chromosomes. It identified that mitotic chromosomes consist of a series of thin filamentous structures that reflect detailed chromatids morphology. These observations provide a new structural framework for understanding chromosome condensation mechanisms during mitosis.

Bork C, Nordestgaard BG, Hedegaard BS et al. · Atherosclerosis · (2026) · View on PubMed ↗ · Free PDF ↗

Single-cell multi-omic integration analysis prioritizes druggable genes and reveals cell-type-specific causal effects in glioblastomagenesis.

This study used single-cell multi-omic integration combined with genome-wide association study (GWAS) data to prioritize druggable genes and infer cell-type-specific causal effects in glioblastomagenesis. By integrating glioma GWAS with bulk and single-cell multi-omics, the authors prioritized genetically supported candidate genes and mapped potential causal mechanisms to specific cell types relevant to glioblastoma development. The approach provides a data-driven route to nominate therapeutic targets and to tailor hypotheses for interventions based on the cellular context of tumor initiation and progression.

Huang YF, Wang KL · Journal of translational medicine · (2026) · View on PubMed ↗ · Free PDF ↗

RFX5 as a regulator of spatial chromatin contacts and gene expression.

This study identified RFX5 as a regulator of spatial chromatin contacts and gene expression by performing CRISPR-mediated RFX5 knockout in A375 cancer cells followed by RNA-seq, ChIP-seq, ATAC-seq, QHR-4C, and Hi-C. RFX5 loss reduced chromatin accessibility and loop strength, decreased CTCF/RAD21 occupancy, and suppressed expression of ~2,000 genes including cancer-associated oncogenic pathways. RFX5 therefore emerges as a CTCF/RAD21-associated factor that helps maintain 3D genome organization and oncogenic transcriptional programs.

Ge X, Zhang Y, Han Y et al. · Communications biology · (2026) · View on PubMed ↗ · Free PDF ↗

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Hematologic malignancies & bone marrow microenvironment

SCRUM-Japan MONSTAR3 hematology cohort: a nationwide multi-omics integrated platform for next-generation precision medicine in hematologic malignancies.

SCRUM-Japan MONSTAR3 established a nationwide, prospective multi-omics integrated platform (SCRUM-Japan MONSTAR3 hematology cohort) enrolling patients with newly diagnosed or relapsed/refractory hematologic malignancies. The cohort collects tumor specimens (bone marrow aspirates/biopsies or lymph node tissues) at diagnosis and at subsequent timepoints to enable integrated genomic and other omics analyses for precision medicine. Scientifically, this platform is designed to improve prognostic stratification, uncover resistance mechanisms, and identify therapeutic vulnerabilities across lymphoma, leukemia, and plasma cell neoplasms.

Matsuda K, Yuda J, Yoshimaru R et al. · International journal of clinical oncology · (2026) · View on PubMed ↗ · Free PDF ↗

Signals from the bone marrow B cell niches shape pre-leukemic fate in a murine model of B cell acute lymphoblastic leukemia.

This work studied how bone marrow (BM) B cell niche signals shape pre-leukemic fate in a murine model of B cell acute lymphoblastic leukemia (B-ALL), focusing on pre-B cell receptor (pre-BCR) signaling. The microenvironmental blockade of the pre-BCR ligand Galectin-1 impaired pre-leukemic cell proliferation and leukemia-initiating capacity, indicating niche control over pre-leukemic fitness. These findings highlight BM niche–dependent mechanisms that could be exploited to prevent progression from pre-leukemic states to overt B-ALL.

Delahaye MC, Léonard S, Pelletier J et al. · Oncogene · (2026) · View on PubMed ↗

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Neurodegeneration (ALS/PD/FTD/Alzheimer) mechanisms & biomarkers

Human retinal organoids functionally bridge a transected optic nerve in a rat model.

This study tested whether heterotopic transplantation of human retinal organoids into the transected optic nerve cavity can restore vision in adult rats. One month after transplantation, treated rats showed partial, sustained functional recovery (direct pupillary light reflex, visually evoked electrophysiology, and visually guided behaviors for at least 3 months) alongside neuroanatomical evidence of structured host–graft coupling across the gap. The work provides a translationally relevant bridge between retinal tissue and a severed optic nerve, supporting organoid-based circuit reconstruction for adult mammalian vision restoration.

Gong Y, Zhu H, Ge L et al. · Cell stem cell · (2026) · View on PubMed ↗

Neocortical tau burden determines the degree of cognitive impairment in individuals with Braak stage V neurofibrillary degeneration.

This study examined whether neocortical tau burden predicts the degree of cognitive impairment in humans with Alzheimer disease neuropathologic change at Braak stage V. Using quantitative computer-assisted positive-pixel assessments to measure neocortical hyperphosphorylated tau (p-tau) burden in individuals with Braak V, the authors found that neocortical tau burden better explained variability in cognitive impairment than existing neuropathologic metrics alone (details truncated in the provided abstract). Scientifically, the results support neocortical p-tau quantification as a more informative biomarker for cognitive outcomes in advanced AD pathology.

Richardson TE, Cherry J, Kandoi S et al. · Acta neuropathologica · (2026) · View on PubMed ↗ · Free PDF ↗

Lipoprotein(a) Levels, Risk of Cardiovascular Events and Benefit of Evolocumab: Findings From the VESALIUS-CV Trial.

This controlled study assessed the prevalence and clinical correlates of Rome IV-defined functional bowel disorders (FBDs) in idiopathic Parkinson’s disease (iPD). In 64 iPD patients and 64 non-neurologic controls, FBDs were diagnosed using the Rome IV Diagnostic Questionnaire and related to non-motor symptoms, mood, and quality of life using validated scales (NMSS, Hamilton, PDQ-39, GIQLI), with multivariable analyses performed (results truncated in the provided abstract). The study clarifies the burden of functional bowel disorders within iPD’s non-motor spectrum and supports more systematic GI symptom assessment in clinical care.

Monguillon V, Marston NA, Bohula EA et al. · Circulation · (2026) · View on PubMed ↗

CHCHD2 and CHCHD10 promoted autophagic clearance of protein aggregates via GABARAPs.

This study examined how mitochondrial proteins CHCHD2 and CHCHD10 promote autophagic clearance of protein aggregates, focusing on their interaction with GABARAPs. The authors identified a CHCHD2–CHCHD10–C1QBP/p32–ATG8-family protein complex that preferentially associates with GABARAPs, and they reported that disease-associated CHCHD2/CHCHD10 mutations impair this autophagy-related function (details truncated in the provided abstract). These findings link CHCHD2/CHCHD10 to selective autophagy machinery and provide a mechanistic basis for how mitochondrial protein mutations may drive neurodegeneration in Parkinson disease, ALS, FTD, and AD.

Wei Z, Zhang M, Tang W et al. · Autophagy · (2026) · View on PubMed ↗

Protein Disulfide Isomerase Disassembles TDP-43/G3BP1 Condensates and Antagonizes TDP-43 Pathological Aggregates.

The study examined how protein disulfide isomerase (PDI) modulates TDP-43 pathology by disassembling TDP-43/G3BP1 condensates and antagonizing pathological TDP-43 aggregates. Wild-type PDI interacted with TDP-43 to attenuate TDP-43 phase separation, competitively displaced G3BP1 to disassemble condensates, and counteracted pathological mislocalization and abnormal phosphorylation. These mechanistic findings suggest PDI as a potential therapeutic target to reduce TDP-43 aggregation relevant to ALS and TDP-43 proteinopathies.

Liu JQ, Liu H, Sun YX et al. · Advanced science (Weinheim, Baden-Wurttemberg, Germany) · (2026) · View on PubMed ↗ · Free PDF ↗

NMN/NAD+ enhances SIRT2-modulated microtubule dynamics to improve mitochondrial and mitophagy functions in senescent cells.

This study tested whether NMN (nicotinamide mononucleotide)/NAD+ enhances SIRT2-mediated microtubule dynamics to improve mitochondrial function and mitophagy in senescent human cells. NMN/NAD+ increased SIRT2-dependent regulation of microtubule stability/dynamics, leading to improved mitochondrial performance and enhanced mitophagy in senescent cells. Scientifically, it supports an NAD+-SIRT2-microtubule axis as a targetable pathway to counter senescence-associated mitochondrial dysfunction.

Cui J, Ren S, Wang B et al. · Autophagy · (2026) · View on PubMed ↗

Neural mesenchymal-like fibroblast-derived migrasomes promote Schwann cell proliferation and migration via tenascin-C transfer during peripheral nerve regeneration.

This study examined how neural mesenchymal-like fibroblast-derived migrasomes influence Schwann cell (SC) behavior during peripheral nerve regeneration. The key finding was that after peripheral nerve injury, neural mesenchymal-like fibroblasts expand and produce migrasomes that promote SC proliferation and migration and provide directional cues, with tenascin-C transfer implicated as the mechanism. The scientific significance is that migrasome-mediated tenascin-C delivery represents a novel intercellular communication route that could be leveraged to enhance peripheral nerve repair.

Ma Y, Wang Q, Yu H et al. · Cell communication and signaling : CCS · (2026) · View on PubMed ↗ · Free PDF ↗

Assessing the role of Subacute Encephalopathy with Seizures in Alcoholics (SESA) syndrome in the development of status epilepticus: a case report and systematic review with individual patients’ analysis.

This article reported a super-refractory status epilepticus (SRSE) case in a patient with confirmed Subacute Encephalopathy with Seizures in Alcoholics (SESA) and also performed a systematic review of SESA progression to status epilepticus. The key finding was that SESA can progress to SRSE, but the relationship between SESA and status epilepticus remains incompletely characterized in the literature. Clinically, it highlights the need for heightened monitoring and early aggressive management when SESA patients deteriorate toward refractory status epilepticus.

Dasara M, Dono F, Evangelista G et al. · BMC neurology · (2026) · View on PubMed ↗ · Free PDF ↗

ERVK activity in CD8+ T cell immune cell compartment in patients with ALS.

This study examined endogenous retrovirus-K (ERVK) integrase (IN) expression in immune-cell compartments by analyzing peripheral blood mononuclear cells (PBMCs) from patients with amyotrophic lateral sclerosis (ALS), focusing on lymphoid and myeloid-derived immune cells. The key finding was that ERVK IN is expressed in these immune cells, supporting a link between ERVK activity and ALS-associated genomic instability in the immune system. These results suggest ERVK IN may contribute to ALS pathobiology beyond the CNS and could represent a biomarker or therapeutic target in ALS immunology.

Sharma S, Cortés-Pérez C, Bird S et al. · Journal of neuroinflammation · (2026) · View on PubMed ↗ · Free PDF ↗

In vivo profiling of astrocyte secretome reveals brain-region specific regulatory networks in a mouse model of amyloid pathology.

This study used in vivo TurboID proximity labeling to profile the astrocyte secretome in a mouse model of amyloid pathology, mapping brain-region specific regulatory networks across disease progression. The key finding was that astrocyte-derived secretory proteins show early, region-dependent alterations—particularly in the entorhinal cortex—enriched for metabolic pathways. These data advance understanding of how astrocyte secretomes may orchestrate region-specific signaling in Alzheimer’s disease-like pathology and highlight candidate secreted regulators for intervention.

Jiang Q, Hu JN, Dong HM et al. · Molecular neurodegeneration · (2026) · View on PubMed ↗ · Free PDF ↗

Engineered neuronal exosomes mediate α-synuclein clearance to ameliorate Parkinson’s disease.

This study developed engineered neuronal exosomes loaded with an α-synuclein (αSyn) aggregation-blocking peptide (sPep) to enhance αSyn clearance and test therapeutic effects in a Parkinson’s disease (PD) context. The key finding was that engineered exosomes extended blood circulation half-life to 3.8 hours, improved brain targeting (2.15% brain signal vs 0.78% for free dye), and were designed to block αSyn aggregation. This supports engineered exosome delivery of aggregation-inhibiting peptides as a promising disease-modifying strategy for PD.

Chen L, Lin X, Fu M et al. · Journal of nanobiotechnology · (2026) · View on PubMed ↗ · Free PDF ↗

Deficient TRPM3-linked mitochondrial Ca2+ influx in natural killer cells associated with myalgic encephalomyelitis/chronic fatigue syndrome.

This study investigated ME/CFS pathomechanisms by examining TRPM3-linked mitochondrial Ca2+ influx in natural killer (NK) cells from individuals with ME/CFS, building on prior evidence of impaired TRPM3-dependent Ca2+ mobilization. Using fluorescence live-cell imaging, the authors assessed downstream mitochondrial Ca2+ handling resulting from TRPM3 dysfunction in NK cells. The findings link TRPM3 channel deficiency to mitochondrial Ca2+ dysregulation in ME/CFS immune cells, offering a potential target to restore NK cell function and reduce post-exertional immune exhaustion.

Magawa CT, Eaton-Fitch N, Muraki K et al. · BMC immunology · (2026) · View on PubMed ↗ · Free PDF ↗

Proximity proteomics reveals a co-evolved LRRK2-regulatory network linked to centrosomes.

This study used BioID proximity proteomics to map LRRK2-associated protein networks and applied evolutionary/structural bioinformatics to interpret co-evolved interactions in the context of Parkinson’s disease biology. The authors identified a co-evolved LRRK2-regulatory module enriched for centrosome- and microtubule-associated cytoskeletal components and characterized new LRRK2 interactors. Defining an LRRK2–centrosome/microtubule network may clarify disease-relevant pathways and suggest targets for therapeutic modulation in familial and idiopathic PD.

Eckert M, Miglionico P, Izzi F et al. · EMBO reports · (2026) · View on PubMed ↗ · Free PDF ↗

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Neuroinflammation & CNS infection

Microglial Ccl4-Ccr5 signaling links systemic inflammation to synaptic loss and memory deficits in chronic kidney disease.

This animal and translational neuroscience study tested whether microglial Ccl4–Ccr5 signaling links systemic inflammation to synaptic loss and memory deficits in chronic kidney disease (CKD). Using a 5/6 nephrectomy rat model, the key finding was that CKD-associated cognitive impairment correlated with microglial activation and reduced synaptic density, with single-cell RNA sequencing and immunofluorescence supporting a mechanistic role for the Ccl4–Ccr5 axis in synaptic phagocytosis. Scientifically, it connects a peripheral inflammatory state to hippocampal synaptic degeneration via a defined microglial signaling pathway, highlighting Ccr5/Ccl4 as a candidate target to preserve cognition in CKD.

Cao Y, Wang J, Li X et al. · Journal of neuroinflammation · (2026) · View on PubMed ↗ · Free PDF ↗

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Genetics & rare neurodevelopmental disorders

Dental and Dentofacial Findings in a Child With CHOPS Syndrome Managed Under General Anesthesia.

This case report described dental and dentofacial findings in an 11-year-old male with CHOPS syndrome (a rare genetic disorder) managed under general anesthesia. The key finding was the presence of multiple dental caries along with characteristic craniofacial and oral features including midface hypoplasia, a narrow/high palatal vault, and enamel hypoplasia on clinical exam and panoramic radiography. Clinically, it highlights previously unreported oral manifestations in CHOPS syndrome and supports early dental surveillance and tailored anesthesia planning for affected children.

Kerimoglu C, Kocaoglu MH, Ozalp N · International journal of paediatric dentistry · (2026) · View on PubMed ↗

FLNB and TTC26 regulate ciliary Hedgehog signaling to maintain intervertebral disc matrix homeostasis in adolescent idiopathic scoliosis.

This mouse genetics study examined whether gene-gene interactions between Filamin B (FLNB; Flnb) and tetratricopeptide repeat domain 26 (TTC26; Ttc26) regulate ciliary Hedgehog signaling to maintain intervertebral disc matrix homeostasis in adolescent idiopathic scoliosis (AIS). The key finding was that double heterozygous mice carrying heterozygous mutations in both Flnb and Ttc26 developed progressive spinal curvature during puberty, whereas single heterozygotes did not show the same phenotype. The scientific significance is that it implicates combined disruption of FLNB and TTC26 in ciliary Hedgehog pathway regulation as a mechanistic contributor to AIS-like spinal instability.

Jiang H, Gao Y, Lai B et al. · Genome biology · (2026) · View on PubMed ↗ · Free PDF ↗

RNF19A::PLAG1-rearranged uterine mesenchymal tumor with myofibroblastic features and focal adipocytic differentiation: broadening the histologic and molecular genetic spectrum of PLAG1-rearranged uterine mesenchymal neoplasms.

The study investigated a rare RNF19A::PLAG1-rearranged uterine mesenchymal tumor with myofibroblastic features in a 50-year-old woman, using histopathology and immunohistochemistry to characterize the tumor. The tumor showed bland spindle-to-epithelioid cells in solid sheets/fascicles with fibrous stroma, low mitotic activity, no necrosis, and focal mature adipocytes, with co-expression of CD34, desmin, estrogen receptor, and progesterone receptor and retained RB1 expression. This expands the histologic and molecular spectrum of PLAG1-rearranged uterine mesenchymal neoplasms and supports RNF19A::PLAG1 as a diagnostic molecular driver even when adipocytic differentiation and myofibroblastic morphology are present.

Yin X, Wang H, Xu J et al. · Virchows Archiv : an international journal of pathology · (2026) · View on PubMed ↗

Gene-specific long-term course, neurodevelopmental outcome and quality of life in patients with LIS1/PAFAH1B1-, DCX-, DYNC1H1-, TUBA1A- and TUBG1-related lissencephaly.

This study followed 47 genetically confirmed lissencephaly patients to determine gene-specific long-term clinical course, neurodevelopmental outcomes, and quality of life for mutations in LIS1/PAFAH1B1, DCX, DYNC1H1, TUBA1A, and TUBG1. The key finding was that disease severity and longitudinal outcomes vary by the underlying gene, with genotype-associated differences in neurodevelopmental trajectory and medical complications. These findings enable more precise prognostication and family counseling in rare lissencephaly syndromes and can guide gene-tailored supportive care planning.

Proepper CR, Schwarz LM, Schuetz SM et al. · Orphanet journal of rare diseases · (2026) · View on PubMed ↗ · Free PDF ↗

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Cardiovascular risk, lipids & atherosclerosis (including FH/Lp(a))

Functional bowel disorders in idiopathic Parkinson’s disease: a Rome IV-based controlled study.

This prespecified analysis from the VESALIUS-CV trial studied whether baseline lipoprotein(a) [Lp(a)] levels predict cardiovascular event risk and modify benefit from evolocumab in patients without prior myocardial infarction or stroke. Among 7557 randomized participants with qualifying atherosclerosis or high-risk diabetes, Cox models assessed adjusted event risk by baseline Lp(a) in the placebo arm and evaluated how Lp(a) influenced evolocumab benefit (details truncated in the provided abstract). The work informs risk stratification and potential personalization of PCSK9 inhibitor therapy based on Lp(a) in primary/secondary-prevention populations without prior MI or stroke.

Yavuz Z, Uzun M, Mutlu T et al. · Neurodegenerative disease management · (2026) · View on PubMed ↗

Oridonin as a novel KDM5C inhibitor alleviates clonal hematopoiesis-induced cardiac aging via H3K4me3-dependent SASP suppression.

The study investigated whether oridonin, a novel KDM5C inhibitor, can alleviate clonal hematopoiesis-induced cardiac aging in the context of TET2-driven CHIP and H3K4me3-dependent SASP regulation. Oridonin reversed CHIP- and aging-associated gene signatures and reduced cardiac aging phenotypes by suppressing SASP in a manner dependent on H3K4me3. These findings suggest KDM5C inhibition by oridonin may be a pharmacologic strategy to mitigate cardiovascular aging risk driven by TET2-CHIP.

Chen X, Zhao Q, Chen L et al. · Acta pharmaceutica Sinica. B · (2026) · View on PubMed ↗ · Free PDF ↗

Familial hypercholesterolaemia in children and adolescents: a European Atherosclerosis Society consensus statement.

This European Atherosclerosis Society consensus statement reviewed and standardized approaches for diagnosing and managing familial hypercholesterolaemia (FH) in children and adolescents, covering heterozygous FH (HeFH) and homozygous FH (HoFH). It emphasizes that early diagnosis and treatment in childhood can extend or normalize life expectancy and reduce premature ASCVD risk, particularly for HoFH where untreated risk is extreme even before adulthood. The guidance is significant for improving awareness, underdiagnosis, and undertreatment of pediatric FH across Europe.

Wiegman A, Bourbon M, Freiberger T et al. · European heart journal · (2026) · View on PubMed ↗

Association of long-COVID with major adverse cardiovascular events and mortality: a real-world data cohort study.

Using a retrospective multicenter real-world cohort from the TriNetX electronic health record network, the study assessed whether long COVID (diagnosed 3–6 months after initial COVID-19) is associated with major adverse cardiovascular events (MACE) and all-cause mortality in adults aged ≥18 years. Long COVID was associated with increased risk of MACE and mortality compared with non–long COVID groups. Scientifically and clinically, it strengthens evidence that persistent post-acute sequelae of SARS-CoV-2 infection contribute to longer-term cardiovascular risk.

Tsai YT, Wang BY, Ho SW et al. · BMC cardiovascular disorders · (2026) · View on PubMed ↗ · Free PDF ↗

Time- and risk-dependent effects of dual antiplatelet therapy targeting the P2Y12 receptor after CABG: A network meta-analysis of graft permeability and clinical outcomes.

This network meta-analysis studied time- and risk-dependent effects of dual antiplatelet therapy (DAPT) targeting the P2Y12 receptor after coronary artery bypass grafting (CABG), comparing aspirin plus clopidogrel or ticagrelor versus aspirin-based regimens and rivaroxaban across follow-up periods and risk strata. The key finding was that the relative effects on graft permeability (saphenous vein graft patency and LIMA occlusion) and clinical outcomes (MI/MACE and major bleeding) varied by time and patient risk profile. This is significant for tailoring post-CABG antithrombotic strategies to balance graft patency against ischemic and bleeding risks.

Zhou Y, Zhang X, Gui W et al. · Journal of thrombosis and thrombolysis · (2026) · View on PubMed ↗

Direct oral anticoagulants versus vitamin K antagonists for atrial fibrillation patients on dialysis: A systematic review and meta-analysis of randomized controlled trials and real-world evidence.

This systematic review and meta-analysis synthesized randomized and real-world evidence comparing direct oral anticoagulants (DOACs) versus vitamin K antagonists (VKAs) for atrial fibrillation in dialysis patients with end-stage renal disease (ESRD). Across included studies, DOACs were evaluated for ischemic stroke, major bleeding, and all-cause mortality, addressing the evidence gap because pivotal DOAC trials excluded dialysis patients (numerical results truncated). The work aims to inform safer anticoagulant selection for AF patients on dialysis by clarifying comparative efficacy and bleeding risk.

Shaheen O, Hamdy M, Afifi IA et al. · Journal of thrombosis and thrombolysis · (2026) · View on PubMed ↗

Lipoprotein(a) and residual cardiovascular risks in Japanese patients with coronary artery disease who achieve guideline-recommended low-density lipoprotein cholesterol goals.

This multicentre retrospective observational study of 1581 Japanese patients with coronary artery disease (CAD) evaluated whether residual cardiovascular risk attributable to lipoprotein(a) [Lp(a)] persists in patients who achieve guideline-recommended low-density lipoprotein cholesterol (LDL-C) goals (<55 mg/dL). Major adverse cardiovascular events (MACE) were compared across Lp(a) strata (e.g., <30, ≥30 and <50, and ≥50 mg/dL) to determine risk differences despite LDL-C control. The study addresses how much Lp(a) contributes to residual risk when LDL-C is already well controlled, informing risk stratification in the absence of established Lp(a)-lowering therapies.

Kataoka Y, Ray KK, Nicholls SJ et al. · European heart journal · (2026) · View on PubMed ↗ · Free PDF ↗

Association between METS-VF and hypertension in U.S.: a cross-sectional analysis of NHANES data.

This cross-sectional analysis of 13,822 U.S. participants from NHANES studied whether the Metabolic Score for Visceral Fat (METS-VF), calculated from age, sex, insulin resistance metabolic score, and waist-to-height ratio, is associated with hypertension. Higher METS-VF was associated with increased odds of hypertension after adjustment for confounders using logistic regression models. If validated longitudinally, METS-VF could provide a non-invasive clinical tool to identify individuals at higher cardiometabolic risk.

Guo Z, Zhang Z, Tian Y et al. · Scientific reports · (2026) · View on PubMed ↗ · Free PDF ↗

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Heart failure & cardiovascular pharmacoeconomics

Cost-effectiveness of finerenone in heart failure with mildly reduced or preserved ejection fraction - Insights from FINEARTS-HF.

This analysis used FINEARTS-HF trial data (N=6,001) to evaluate the cost-effectiveness of finerenone in patients with heart failure with mildly reduced or preserved ejection fraction (HFmrEF/HFpEF) in the United States and Germany using a cohort-based Markov model. Finerenone was cost-effective under modeled horizons, with results sensitive to the analytic time horizon (in-trial vs lifetime). The findings support health-economic justification for finerenone adoption in HFmrEF/HFpEF populations beyond clinical efficacy alone.

Boettger P, Sedighi J, Sohns C et al. · European journal of heart failure · (2026) · View on PubMed ↗

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Diabetes, obesity & metabolic hormones (GLP-1/SGLT2/DPP-4, etc.)

Tirzepatide Versus Intensified Conventional Care After 2 Years of Treatment in Early Type 2 Diabetes : A Randomized Clinical Trial.

This randomized phase 4 trial (SURPASS-EARLY) studied tirzepatide versus intensified conventional care in adults with early type 2 diabetes who had inadequate glycemic control on diet, exercise, and metformin. Tirzepatide demonstrated improved efficacy and safety outcomes over 2 years compared with intensified conventional care (details truncated in the provided abstract). Clinically, the trial supports early initiation of the dual GIP/GLP-1 receptor agonist tirzepatide to achieve more durable glycemic control in early T2D.

Del Prato S, Heine RJ, Pérez Manghi FC et al. · Annals of internal medicine · (2026) · View on PubMed ↗

The safety and efficacy of semaglutide in people with schizophrenia spectrum disorders: systematic review and meta-analysis of randomised controlled trials.

This systematic review and meta-analysis evaluated the safety and efficacy of the GLP-1 receptor agonist semaglutide (and related trials with tirzepatide) in people with schizophrenia spectrum disorders (SSDs) using placebo-controlled randomized controlled trials. Across included RCTs, semaglutide showed evidence relevant to weight and metabolic outcomes while assessing tolerability in SSD populations, addressing a gap in evidence versus the general population. Clinically, the results inform whether semaglutide can be used to reduce obesity/metabolic dysfunction–related morbidity in SSD patients.

Trott M, Arnautovska U, Johnston D et al. · BJPsych open · (2026) · View on PubMed ↗ · Free PDF ↗

Angiogenic T cells and cognitive function in older adults with type 2 diabetes treated with GLP-1 receptor agonists.

This cross-sectional study assessed whether circulating angiogenic T cells (“Tang cells”) relate to cognitive function in older adults with type 2 diabetes mellitus (n=154, ages 60–80) and whether associations differ by GLP-1 receptor agonist therapy. Tang cell levels were associated with cognitive performance, and GLP-1 receptor agonist treatment (GLP-1RA plus metformin vs metformin alone) appeared to influence this relationship (specific statistics truncated). If validated longitudinally, Tang cells could help link vascular/angiogenic biology to cognition and inform risk stratification in older T2DM patients on GLP-1RA.

Longo M, Caruso P, Auriemma MC et al. · Aging clinical and experimental research · (2026) · View on PubMed ↗ · Free PDF ↗

Associations of coffee, alcohol, medication and supplement use with the metabolome and lipidome: an observational study of premenopausal women.

This observational study in 702 premenopausal women assessed how frequencies of coffee and alcohol intake, and use of medications and supplements, associate with the blood metabolome and lipidome using untargeted metabolomics and lipidomics. Multivariable linear regression identified specific metabolites and lipid species linked to these lifestyle and exposure factors after adjustment for confounders. The results provide hypothesis-generating evidence that combined lifestyle/medication/supplement behaviors measurably shape circulating metabolic and lipid profiles in premenopausal women.

Khan S, Lyu Y, Mamillapalle V et al. · Metabolomics : Official journal of the Metabolomic Society · (2026) · View on PubMed ↗ · Free PDF ↗

Beyond glycemic control: differential effects of empagliflozin and sitagliptin on insulin sensitivity and a shared increase in adropin in type 2 diabetes.

This randomized, open-label, parallel-group superiority trial compared empagliflozin versus sitagliptin (both added to metformin) in adults with type 2 diabetes, focusing on serum adropin, insulin sensitivity, glycemic control, lipids, and inflammation. The study found differential effects on insulin sensitivity while both treatments shared an increase in adropin levels. These results suggest that SGLT2 inhibition and DPP-4 inhibition may modulate insulin resistance through partially overlapping hepatokine (adropin) pathways, informing mechanistic understanding beyond glucose lowering.

Taha OS, Azami G, Saed L et al. · BMC endocrine disorders · (2026) · View on PubMed ↗ · Free PDF ↗

A randomised clinical trial testing the safety of and metabolic responses to short-term duodenal infusion of recombinant RORDEP1 in healthy men.

This randomized, placebo-controlled, crossover trial tested the safety and metabolic responses to short-term duodenal infusion of recombinant RORDEP1 (r-RORDEP1) in 17 healthy men aged 18–35 years after a liquid mixed meal. The study specifically targeted whether r-RORDEP1 alters metabolic outcomes consistent with preclinical effects on incretins and hepatic insulin sensitivity. The results are important for early translational evaluation of gut-microbiota–derived peptide therapeutics as potential glucose-lowering agents.

Gæde J, Fan Y, Lyu L et al. · Diabetologia · (2026) · View on PubMed ↗ · Free PDF ↗

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Inflammation, immune modulation & microbiome

Soil-derived microbiota induces T regulatory cells and protect against mouse colitis, metabolic disease, and sepsis.

This preclinical mouse study tested whether colonization with soil-derived environmental (ENV) microbiota induces regulatory T (Treg) cells and protects against mouse colitis, metabolic disease, and sepsis. The key finding was that sustained colonization—especially with Gram-negative bacteria—shifted both local and systemic immunity toward anti-inflammatory responses characterized by increased Treg activity and improved disease outcomes. Scientifically, it supports a more translational model of microbiome–immune interactions and suggests that environmental microbial exposures can modulate systemic inflammation relevant to multiple disease states.

Szurek EA, Ngo VL, Abo H et al. · Gut microbes · (2026) · View on PubMed ↗ · Free PDF ↗

Association between C-reactive protein to lymphocyte ratio and depression: A population-based study.

This population-based study used NHANES 2015–2023 data (n=12,868) to examine whether the C-reactive protein to lymphocyte ratio (CLR; hs-CRP/lymphocyte count) is associated with depression and suicidal ideation measured by PHQ-9. Higher CLR was associated with greater depressive symptom burden and suicidal ideation after multivariable adjustment (details truncated in the abstract). If confirmed, CLR could serve as an accessible inflammatory biomarker to help stratify depression risk in the general population.

Zheng Z, Wu J, Shi Q · Progress in neuro-psychopharmacology & biological psychiatry · (2026) · View on PubMed ↗

Emerging Corynebacterium Species Infections in the Shadow of Radiation Therapy: A Case Series in Cancer Patients.

This case series studied three culture-confirmed infections caused by Corynebacterium species in cancer patients receiving radiation therapy, including two Corynebacterium striatum skin/soft-tissue infections and one Corynebacterium matruchotii vaginal infection. Patients presented with foul-smelling discharge and delayed wound healing in previously irradiated tissues, with organism identification performed using MALDI-TOF MS (Bruker Biotyper) and standard microbiology. The findings highlight radiation-associated immunocompromise as a setting where emerging Corynebacterium pathogens should be considered and accurately identified.

Gupta A, Biswal D, Dagar A et al. · Indian journal of medical microbiology · (2026) · View on PubMed ↗ · Free PDF ↗

Exploratory gut microbiota-host interaction in parkinson’s disease: integrative multi-omics analysis of metabolic and epigenetic pathways.

This integrative multi-omics study used a two-stage Mendelian randomization (MR) framework plus transcriptome/epigenome-wide regulatory analyses and colocalization to explore gut microbiota–host interaction mechanisms in Parkinson’s disease (PD). It used MiBioGen gut microbiota data for discovery MR and Dutch Microbiome Project (DMP) mbQTL data for replication MR to genetically dissect microbiota-linked metabolic and epigenetic pathways implicated in PD susceptibility (specific implicated taxa/genes truncated). The approach provides a causal, systems-level route to prioritize microbiota-related molecular pathways that may underlie PD risk.

Li G, Ye X, Zhou T et al. · AMB Express · (2026) · View on PubMed ↗ · Free PDF ↗

Microbiota-derived butyrate inhibits colonic epithelial pyroptosis and mitigates DSS-induced colitis via interacting with aryl hydrocarbon receptor.

This study tested whether microbiota-derived butyrate inhibits colonic epithelial pyroptosis and mitigates DSS-induced colitis through interaction with the aryl hydrocarbon receptor (AhR) in mice and cultured colonic epithelial cells (FHC) stimulated with LPS+ATP. The key finding was that butyrate reduced epithelial pyroptosis and colitis severity, and that this protective effect depended on AhR signaling (including evidence using GSDMD-knockout mice to implicate pyroptosis machinery). These results support butyrate/AhR as a mechanistic therapeutic axis for ulcerative colitis by targeting epithelial pyroptosis.

Zou F, Wu Z, Wang S et al. · Journal of translational medicine · (2026) · View on PubMed ↗ · Free PDF ↗

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Respiratory critical care & pulmonary physiology

Structured Exercise Regimen in Pulmonary Hypertension-Right Ventricular Failure in an Ovine Model.

This JoVE study investigated the effects of a structured exercise regimen on pulmonary hypertension–right ventricular failure (PH-RVF) in an ovine model. Using eight Dorset cross sheep with PH-RVF induced by ligation of the left pulmonary artery and progressive occlusion of the main pulmonary artery with an inflatable cuff, the authors implemented an eight-week exercise protocol to characterize exercise-induced stress in this disease model. The model and regimen provide a controlled platform to study how exercise modulates PH-RVF pathophysiology and to inform future translational exercise strategies.

Bulard BA, Kumpfbeck AR, Woo Y et al. · Journal of visualized experiments : JoVE · (2026) · View on PubMed ↗

Determinants of tidal recruitment/derecruitment assessed by electrical impedance tomography in spontaneously breathing ARDS patients.

This secondary analysis investigated bedside determinants of tidal recruitment/derecruitment (R/D) measured by electrical impedance tomography (EIT) in spontaneously breathing ARDS patients on pressure support ventilation (PSV). It focused on how physiological factors such as respiratory mechanics and regional mechanics relate to EIT-derived R/D at two PEEP strategies (EIT-selected PEEP vs low PEEP/FiO2 table). The findings are clinically important because they aim to make EIT-based identification of tidal R/D more actionable during assisted ventilation in ARDS.

Perez J, Leali M, Spinelli E et al. · American journal of respiratory and critical care medicine · (2026) · View on PubMed ↗

Impact of Biologics on Oscillometry Defined Small Airway Dysfunction in Uncontrolled Asthma.

This article assessed how biologic therapies affect oscillometry-defined small airway dysfunction (SAD) in uncontrolled asthma, using forced oscillometry technique (FOT) as the measurement method. It reports that clinical trials of mepolizumab, dupilumab, and tezepelumab produced significant, clinically meaningful improvements in oscillometry-defined SAD, whereas benralizumab effects were less clear in the provided excerpt. The findings support SAD as a treatable trait and help clinicians select biologics based on peripheral lung physiology in addition to type 2 inflammation.

Greig R, Suter P, Chan R et al. · Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · (2026) · View on PubMed ↗ · Free PDF ↗

[Use of inhaled nitric oxide during neonatal transport - a review of seven years of experience].

This review evaluated the use of inhaled nitric oxide (iNO) during neonatal transport over seven years of experience from Hungary’s Peter Cerny Foundation Neonatal Transport Service. The authors describe how iNO was used as a pulmonary vasodilator to support persistent pulmonary hypertension of the newborn during transport until tertiary care handover (outcomes and quantitative results are truncated). The review supports iNO as a practical bridge therapy for neonatal pulmonary hypertension in transport settings when immediate on-site intensive care is required.

Lantos L, Somogyvári Z, Széll A et al. · Orvosi hetilap · (2026) · View on PubMed ↗

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Reproductive health & pregnancy/perinatal medicine

Genome-wide meta-analysis identifies genetic drivers of bile acid metabolism in intrahepatic cholestasis of pregnancy.

This genome-wide meta-analysis studied genetic drivers of bile acid metabolism in intrahepatic cholestasis of pregnancy (ICP) by combining genome-wide association study data from FinnGen, deCODE, the Estonian Biobank, the Danish Blood Donor Study, and Copenhagen Hospital Biobank (4,738 women with prior ICP and 436,834 female controls). The analysis identified 26 genome-wide significant loci (including 10 novel associations) and prioritized candidate genes using lead-SNP expression quantitative trait locus (eQTL) approaches (lead SNP expression quan[…]). These findings refine the genetic architecture of ICP and highlight bile-acid–related pathways that could inform risk stratification and mechanistic targets for therapy.

Tyrmi JS, Karjalainen J, Venkatesh SS et al. · Nature communications · (2026) · View on PubMed ↗ · Free PDF ↗

Antenatal N-acetylcysteine supplementation in pregnant women with impending preterm birth: a prospective randomized placebo-controlled trial.

This pilot prospective randomized placebo-controlled trial studied antenatal N-acetylcysteine (NAC) supplementation in pregnant women with impending preterm birth (singletons at moderate or severe risk; NCT03596125; n=20 NAC vs n=19 placebo). The trial tested whether NAC given orally (80 mg/kg/day then 40 mg/kg/day) or via IV bolus/infusion followed by oral dosing could replenish glutathione (GSH) stores and improve outcomes related to preterm birth risk. Establishing whether antenatal NAC corrects the GSH depletion linked to preterm birth would support a potential preventive intervention before delivery.

Küster A, Legrand A, Vibet MA et al. · Pediatric research · (2026) · View on PubMed ↗ · Free PDF ↗

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Methodology, guidelines, reviews & consensus (non-disease-specific)

Safety and efficacy of liposomal iron for iron deficiency anemia in pediatric population: A systematic review and meta-analysis of randomized controlled trials.

This systematic review and meta-analysis evaluated the safety and efficacy of liposomal iron compared with conventional oral iron formulations for iron deficiency anemia in pediatric patients using randomized controlled trials. Across searches up to February 21, 2026, the analysis synthesized RCT evidence on treatment effectiveness and adverse events, focusing on tolerability advantages of liposomal iron in children (results truncated in the provided abstract). The findings aim to guide pediatric IDA treatment selection by clarifying whether liposomal iron improves efficacy and reduces gastrointestinal side effects that limit adherence.

Alharran AM, Almutairi EY, Alazemi WB et al. · European journal of pediatrics · (2026) · View on PubMed ↗

Mitochondrial Carrier SLC25A13 Drives Ferroptosis Resistance and Immune Evasion via a STAT3-IFI6 Circuit in Breast Cancer.

This study investigated how the mitochondrial carrier SLC25A13 influences ferroptosis and immune evasion in triple-negative breast cancer (TNBC). SLC25A13 was upregulated in breast cancer and associated with poor prognosis and reduced CD8+ T-cell infiltration; mechanistically, SLC25A13 promoted tumor growth and metastasis while suppressing ferroptosis and weakening CD8+ T-cell cytotoxicity via a STAT3–IFI6 circuit linked to enhanced complex I–dependent oxidative phosphorylation and reduced mitochondrial ROS. These results suggest targeting SLC25A13/STAT3–IFI6 signaling to restore ferroptosis and improve antitumor immunity in TNBC.

Zhu Y, Tang Y, Chen Y et al. · Advanced science (Weinheim, Baden-Wurttemberg, Germany) · (2026) · View on PubMed ↗ · Free PDF ↗

An in vivo parallelized reporter assay to uncover tissue-specific splicing regulatory sequences in a multicellular animal.

The study developed an in vivo parallelized reporter assay (PRA) in Caenorhabditis elegans neurons and muscle cells to identify tissue-specific intronic splicing enhancer and silencer sequences. Using thousands of randomized intronic sequences, the authors screened cis-regulatory motifs and identified nearly 200 sequences that regulate splicing in a tissue-dependent manner. This provides a scalable in vivo technique to map splicing regulatory logic beyond cell culture, enabling more accurate tissue-context interpretation of intronic variants.

Bhatnagar S, Ho J, Sadek NH et al. · Nucleic acids research · (2026) · View on PubMed ↗

Membrane ATG8ylation in secretory autophagy.

This article reviewed and synthesized current evidence on membrane ATG8ylation as a requirement for secretory autophagy, where ATG8-family proteins are conjugated to membranes to support unconventional protein secretion. It proposes a cell-biological framework classifying secretory autophagy pathways by discrete membrane ATG8ylation at specific vesicular intermediates. The significance is that it clarifies how ATG8 conjugation mechanistically governs secretion routes, guiding future experiments and therapeutic targeting of secretory autophagy.

Debnath J, Leidal AM · Autophagy · (2026) · View on PubMed ↗

Guidance for the assessment of the dietary intake and gastrointestinal or nutrition impact symptoms etiologic criterion of Global Leadership Initiative on Malnutrition: A modified-Delphi study.

This modified-Delphi consensus study developed guidance for assessing the GLIM (Global Leadership Initiative on Malnutrition) etiologic criterion related to reduced dietary intake or assimilation (digestion/absorption). Using a working group (n=10) and global expert panel (n=30) across three Delphi rounds with 75% agreement as the consensus threshold, the authors produced 15 guidance statements to standardize clinical identification of this criterion. The output is significant for improving consistency of malnutrition diagnosis and enabling more reliable nutrition assessment in practice.

Blaauw R, Keller H, Mills CM et al. · JPEN. Journal of parenteral and enteral nutrition · (2026) · View on PubMed ↗ · Free PDF ↗

Neoplasm Adverse Events Associated With Anti-Type 2 Biologics: An FAERS Database Pharmacovigilance Analysis Study.

This pharmacovigilance study analyzed FDA Adverse Event Reporting System (FAERS) reports for neoplasm-related adverse events associated with anti–Type 2 biologics—omalizumab (anti-IgE), dupilumab (anti-IL-4Rα), benralizumab (anti-IL-5R), reslizumab, and mepolizumab (anti-IL-5)—restricted to the asthma indication. The key finding was an association between these biologics and neoplasm-related adverse events in FAERS signals, with results compared across the five drugs using the study’s neoplasm-AE assessment approach. These findings are clinically significant as they motivate further pharmacoepidemiologic and mechanistic studies to clarify whether any causal cancer risk exists beyond background incidence in asthma patients.

Lyu W, Xu R, Chen L et al. · Cancer medicine · (2026) · View on PubMed ↗ · Free PDF ↗

The transmembrane segments of SARS-CoV-2 nsp3 govern viral intracellular trafficking.

This mechanistic virology study investigated how SARS-CoV-2 nonstructural protein 3 (nsp3) transmembrane segments control viral intracellular trafficking in the context of ER–ERGIC membrane targeting. The key finding was that the first transmembrane helix of nsp3 acts as an “address code,” inserting into the ER via SEC61A1 during translation and being escorted to the ERGIC by COPII factors SAR1A and LMAN1; disrupting this helix trapped viral RNA in the cytosol and impaired replication. The scientific significance is that host-targeted interventions modeled on this helix (including a 24-residue peptide and AAV9-delivered peptide) reduced lung viral RNA and pathology in mice, identifying a potential antiviral strategy.

Cao M, Qin L, Zhang H et al. · Cell & bioscience · (2026) · View on PubMed ↗ · Free PDF ↗

Ginger supplementation and metabolic health: an umbrella review of meta-analyses of randomized trials.

This umbrella review evaluated randomized-trial meta-analyses of ginger supplementation for metabolic health outcomes across populations included in the underlying studies. The key finding was an overall synthesis of evidence on ginger’s effects on metabolic parameters (e.g., glycemic and lipid-related measures), based on extracted trial-level dosing and duration from prior meta-analyses. Clinically, it helps determine whether ginger is supported as an adjunct intervention for metabolic risk reduction and identifies where evidence quality or outcome consistency remains limited.

Musazadeh V, Morvaridi M, Hosseini-Roknabadi SM et al. · Diabetology & metabolic syndrome · (2026) · View on PubMed ↗ · Free PDF ↗

Optimizing Care for Growth and Puberty in Duchenne Muscular Dystrophy: A Survey of Clinical Practice in the OPTIMIZE DMD Consortium.

The OPTIMIZE DMD Consortium survey studied current clinical practice patterns for growth and puberty evaluation and management in individuals with Duchenne muscular dystrophy (DMD) among consortium clinicians. The key finding was that real-world endocrine care practices vary relative to the 2018 DMD Care Considerations, indicating gaps in standardized assessment and management of growth/puberty concerns. This is significant for updating guidance and improving endocrine outcomes in DMD care pathways.

Wood CL, Babalola F, Benjamin RW et al. · Muscle & nerve · (2026) · View on PubMed ↗ · Free PDF ↗

Body composition in male hypogonadism: practical considerations to the use of dual-energy x-ray absorptiometry.

This review examined practical considerations for using dual-energy X-ray absorptiometry (DXA) to assess body composition in male hypogonadism, a condition linked to altered lean mass, increased fat mass (including visceral adiposity), and osteosarcopenic obesity risk. The key finding was that DXA can be a useful tool but requires careful interpretation in the context of hypogonadism-related changes and related comorbidities. Scientifically, it helps standardize body-composition measurement approaches to better quantify cardiometabolic and frailty risk in hypogonadal men.

Delbarba A, Amer M, Vena W et al. · Reviews in endocrine & metabolic disorders · (2026) · View on PubMed ↗ · Free PDF ↗

Real-world pharmacovigilance analysis of drug-induced liver injury in 18-65 years: Based on the FDA adverse event reporting system (FAERS).

This real-world pharmacovigilance study analyzed drug-induced liver injury (DILI) epidemiology and drug-specific signals in adults aged 18–65 years using the FDA Adverse Event Reporting System (FAERS) from 2004–2024. Across 180,659 DILI cases, it applied disproportionality methods—reporting odds ratio (ROR), proportional reporting ratio (PRR), Bayesian confidence propagation neural network (BCPNN), and multi-item gamma Poisson shrinker (MGPS)—to identify drugs with significant DILI signals and evaluated time-to-onset patterns (time-to-onset [truncated]). The results help characterize DILI risk profiles in a clinically important age group and can guide signal detection and prioritization for further study and regulatory review.

Wang X, Wang Y, Hu T et al. · Research in social & administrative pharmacy : RSAP · (2026) · View on PubMed ↗

The 2024 McDonald criteria for the diagnosis of multiple sclerosis: implications for clinical practice.

This review article evaluated the 2024 McDonald criteria for diagnosing multiple sclerosis (MS) and translated the updated framework into implications for clinical practice. It highlights a more biologically anchored approach that integrates radiological and cerebrospinal fluid evidence, including the optic nerve as a fifth dissemination-in-space site, advanced MRI markers such as the central vein sign and paramagnetic rim lesions, and the kappa free light chain index as a quantitative alternative to oligoclonal bands (in selected patients with hi[…]). These updates aim to improve diagnostic accuracy and enable earlier MS diagnosis using modern imaging and CSF biomarkers.

Arun T, Petheram K, Braithwaite T et al. · Practical neurology · (2026) · View on PubMed ↗

Comparative efficacy of traditional Chinese exercises in low back pain: a systematic review and network meta-analysis.

This systematic review and network meta-analysis compared randomized controlled trials of traditional Chinese exercises (TCEs) for low back pain across multiple TCE modalities and combinations. The analysis identified relative efficacy differences among TCE interventions, supporting an “optimal” approach among the compared exercise strategies (specific rankings/effect sizes are truncated in the abstract). Clinically, this helps guide evidence-based selection of TCE regimens for low back pain management.

Xu G, Zhang M, Hao Z et al. · Complementary therapies in clinical practice · (2026) · View on PubMed ↗

Real-World Safety and Retention of Tofacitinib in Elderly Versus Non-elderly Patients With Rheumatoid Arthritis: A Retrospective Cohort Study in Taiwan.

This retrospective cohort study in Taiwan compared real-world tofacitinib retention and discontinuation factors between elderly (≥65 years, n=82) and non-elderly (<65 years, n=224) patients with rheumatoid arthritis (RA). Drug retention differed by age group and the study identified clinical factors associated with tofacitinib discontinuation. The findings help clinicians anticipate persistence and discontinuation risks when prescribing the JAK inhibitor tofacitinib in older versus younger RA populations.

Chiang LH, Tsai PH, Chen YF et al. · International journal of rheumatic diseases · (2026) · View on PubMed ↗

Age-dependent nuclear accumulation of a membrane-associated NAC transcription factor GER1 activates SA biosynthesis to promote leaf senescence in Arabidopsis.

This work investigated how the membrane-associated NAC transcription factor GERAS1 (GER1/GERAS1) controls age-dependent leaf senescence in Arabidopsis by regulating senescence-associated biosynthesis of salicylic acid (SA). GER1 expression increased with plant age and its protein translocated from the plasma membrane to the nucleus, with the activation-tagging mutant ger1-D causing early senescence and GER1 disruption delaying senescence. The study links age-dependent nuclear accumulation of GER1 to SA biosynthesis and provides a mechanistic framework for controlling senescence timing in plants.

Wang Y, Wang Y, An F et al. · Molecular plant · (2026) · View on PubMed ↗

Plant viruses hijack and stabilize host Ubiquitin-Specific Protease 14 to prevent viral protein degradation for efficient infection.

This study examined how plant viruses prevent viral protein degradation by hijacking and stabilizing host Ubiquitin-Specific Protease 14 (UBP14) during infection in Nicotiana benthamiana. Ubiquitinome profiling showed reduced UBP14 ubiquitination and increased UBP14 accumulation across potyvirus infections, and the potyviral cylindrical inclusion (CI) protein bound UBP14 to suppress its ubiquitination, recruit it to viral replication complexes, and deubiquitinate/stabilize viral replication components. These results reveal a conserved viral strategy to enhance infection efficiency by directly manipulating host deubiquitination machinery.

Zhuang X, Qiu Y, Du X et al. · Molecular plant · (2026) · View on PubMed ↗

How to make big data accessible to plant biologists and beyond: Ten years of lessons from TBtools.

This article reviewed how TBtools, a bioinformatics platform, has made big data and omics analyses more accessible to plant biologists over the past decade. It summarizes lessons learned from TBtools development to address bottlenecks in data exploration and evidence integration as datasets grow in scale and complexity. The review highlights TBtools as a practical infrastructure for enabling systems-level, data-driven plant research beyond traditional single-gene approaches.

Feng J, Chen C, Wu Y et al. · Molecular plant · (2026) · View on PubMed ↗ · Free PDF ↗

Utility of Acupuncture Therapy for Adult Chronic Daily Headache Prophylaxis: A Systematic Review and Meta-Analysis.

This systematic review and meta-analysis evaluated the sustained prophylactic efficacy of acupuncture for adult chronic daily headache (CDH) using randomized controlled trials identified through multiple databases up to September 2025. Across trials, acupuncture was assessed for effects on headache frequency, headache days, intensity, duration, and analgesic use, with subgroup analyses by treatment modality and CDH subtype. The study synthesizes evidence to clarify whether acupuncture provides clinically meaningful preventive benefit for CDH compared with other interventions.

Nie Y, Jing R, Song Z et al. · Medical science monitor : international medical journal of experimental and clinical research · (2026) · View on PubMed ↗ · Free PDF ↗

Efficacy of vibration therapy on physical function, activity and participation in people with stroke: a systematic review and meta-analysis of randomized controlled trials.

This systematic review and meta-analysis evaluated randomized controlled trials of vibration therapy (VT) for improving physical function, activity, and participation in people with stroke. The key finding was that VT significantly improved physical function outcomes (including motor function and balance-related measures) and reduced spasticity, based on pooled effect sizes across 37 RCTs (n=1492). Clinically, VT appears to be an evidence-supported rehabilitation modality for stroke-related functional impairments, though heterogeneity and study quality should be considered.

Wang Y, Wang J, Lei B et al. · Journal of neuroengineering and rehabilitation · (2026) · View on PubMed ↗ · Free PDF ↗

Drug-induced psoriasis following sacubitril/valsartan: a case report and literature review.

This case report described drug-induced psoriasis following sacubitril/valsartan (SV) therapy in a middle-aged male, with clinical rash features of well-demarcated red/violaceous scaly plaques. The temporal association with SV and subsequent diagnosis of psoriasis supported SV as a potential trigger. The report is clinically significant because it alerts clinicians to psoriasis as a possible adverse effect of SV, enabling earlier recognition and management in patients treated for hypertension or heart failure.

Tang T, Guo M, Yu H et al. · BMC cardiovascular disorders · (2026) · View on PubMed ↗ · Free PDF ↗

The Effect of Menstrual Cycle Phase, Symptoms, Motivation, and Readiness to Perform on Resistance Training Performance.

This study evaluated whether resistance-training kinematic performance varies across menstrual cycle phases over two mesocycles and whether symptoms, motivation, and readiness relate to performance in participants monitored during typical training. The key focus was day-to-day changes in kinematic outputs rather than single timepoint testing. The findings are relevant for optimizing resistance training prescriptions by accounting for menstrual-cycle–associated variability in performance and perceived readiness.

Munteanu G, Halson SL, Huynh M et al. · Sports medicine (Auckland, N.Z.) · (2026) · View on PubMed ↗ · Free PDF ↗

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Generated automatically on May 26, 2026 from PubMed’s trending articles. Summaries are AI-generated; always consult the original publication for clinical or research decisions.