PubMed Trending Research Digest — June 15, 2026

Automated digest · 99 articles · 15 research areas · June 15, 2026

Overview

This week’s digest is dominated by immune–metabolic cross-talk and precision stratification. Multiple papers connect inflammation to metabolic substrates and signaling—such as lactate/lactylation signatures in sepsis, immunometabolic macrophage states after stroke, and integrative biomarkers (e.g., GDF-15, CTI-CVAI, TyG-BMI) that aim to predict cardiovascular and cardiometabolic risk across disease stages. In parallel, several oncology studies emphasize immune escape and microenvironmental control: from MICA/MICB–NKG2D dysregulation in cervical cancer to tumor-stroma axes (ADSC CCL8–HIF-1α, FN1 mechanobiology) and metabolic-epigenetic bridges like NNMT and tiRNA-mediated resistance to anti–PD-1 therapy.

A second major theme is “systems” approaches to therapy and measurement—spanning from mechanistic cell biology to real-world implementation. Reviews and studies highlight organelle quality control and autophagy/mitophagy regulation (STING1-driven mitophagy; lipid control of autophagy; ferroptosis-related pathways), while clinical and translational work focuses on improving how therapies are delivered and monitored (expanded-access operational logistics for tofersen in SOD1+ ALS; remote monitoring workflows in breast cancer; digital/EEG-based biomarker estimation in Alzheimer’s; wearable-based functional tracking in MS). Finally, microbiome and neuroinflammation threads recur across dementia and allergy prevention, with evidence linking oral dysbiosis and circadian–gut–immune coupling to neurodegenerative risk, and probiotic strain/timing considerations for allergic disease.

Overall, the dominant message is that better outcomes increasingly depend on mapping dynamic biological states—immune, metabolic, microbial, and cellular—then using those maps to tailor interventions (drug dosing, patient selection, or targeted therapeutics) rather than relying on single-pathway or one-size-fits-all strategies.

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Cancer immunotherapy & immune escape

Odronextamab: a bispecific antibody for follicular lymphoma.

This review studied odronextamab, a CD20xCD3 bispecific antibody, in patients with relapsed/refractory follicular lymphoma (including data from the ELM-1 and ELM-2 trials). It reports that odronextamab’s T-cell–redirecting mechanism produces clinically meaningful efficacy with a defined safety profile across these studies. These findings support odronextamab as a chemo-free therapeutic option for relapsed/refractory follicular lymphoma and help frame its role in patients with early progression (POD24).

Garcia-Sancho AM, Cabero-Martínez A, Gutierrez NC · Expert opinion on investigational drugs · (2026) · View on PubMed ↗

ADSC-Derived CCL8 Regulates HIF-1α Signaling and Promotes Colorectal Cancer Progression in a 3D Coculture Platform.

This study examined how adipose-derived stem cells (ADSCs) influence colorectal cancer (CRC) progression by regulating HIF-1α signaling using a human 3D oxygen-permeable PDMS coculture chip with CRC cells. It reports that cancer-associated ADSCs secrete CCL8, which activates HIF-1α–related signaling in the tumor microenvironment and promotes CRC progression in the 3D coculture system. The significance is that the ADSC-derived CCL8–HIF-1α axis may represent a mechanistic vulnerability for precision targeting of CRC within the tumor microenvironment.

Yun JE, Son Y, Seo J et al. · Cancer science · (2026) · View on PubMed ↗ · Free PDF ↗

Implementation of smoking cessation interventions in real-world lung cancer screening: a RE-AIM-guided scoping review.

This case report studied a 15-year-old Shih Tzu with conjunctival amelanotic melanoma after incomplete surgical resection to assess adjuvant topical mitomycin C (MMC) therapy. The key finding was the clinical course and outcome following topical MMC after debulking of tumor spread across the bulbar conjunctiva and third eyelid, with no systemic metastases detected on imaging. Scientifically and clinically, it provides veterinary ophthalmology evidence for MMC as an adjuvant option in incompletely resected conjunctival melanoma.

Harrison NJ, Rankin NM, Paul CL et al. · Journal of the National Cancer Institute · (2026) · View on PubMed ↗

MICA/MICB-Mediated NKG2D Immune Escape in Cervical Cancer: Single-Cell Transcriptomic Mapping of Radionuclide Therapy Targets for Precision Radioimmunotherapy.

This study mapped mechanisms of immune escape in cervical cancer by focusing on the MICA/MICB–NKG2D ligand axis and used single-cell transcriptomic analysis to identify radionuclide therapy targets for precision radioimmunotherapy. The key finding is that cervical tumors show dysregulation of MICA/MICB expression that contributes to NKG2D-mediated immune escape, affecting the targetability of NKG2D-armed radiolabeled probes. The significance is that single-cell profiling can guide selection and optimization of NKG2D-based radioimmunotherapy targets in cervical cancer.

Ci J, Wang C, Wang Y et al. · Cancer biotherapy & radiopharmaceuticals · (2026) · View on PubMed ↗

SGO1 and SGO2 are Associated With Disease Progression and an Immunosuppressive Microenvironment in Papillary Renal Cell Carcinoma.

This study used integrative multi-omics analyses of TCGA, GTEx, and GEO datasets to characterize SGO1 and SGO2 expression and their relationship to disease progression and immune microenvironment features in papillary renal cell carcinoma (KIRP). Higher SGO1/SGO2 expression was associated with worse clinical outcomes and an immunosuppressive tumor microenvironment, suggesting roles in tumor progression and immune evasion. These results position SGO1/SGO2 as potential prognostic biomarkers and mechanistic targets for immunomodulatory strategies in KIRP.

Fu H, Ibrohimov A, Zheng H et al. · Cancer medicine · (2026) · View on PubMed ↗ · Free PDF ↗

Systemic metabolic, hormonal, and glycomic remodeling during a 72-hour fast in healthy adults: a pilot study.

This pilot study investigated integrated metabolic, hormonal, and glycomic remodeling during a 72-hour water-only fast in five healthy adults using longitudinal sampling at baseline (T0), post-fasting (T1), and after 11 days of refeeding (T2). The key finding is that fasting triggers a distinct biphasic, time-dependent response across biochemical, endocrine, inflammatory, and glycomic parameters that normalizes or shifts again after refeeding. Scientifically, it provides a systems-level map of coordinated metabolic–endocrine–glycan adaptations to fasting that may inform metabolic health and fasting-related interventions.

Lauc G, Brlek P, Bulić L et al. · Croatian medical journal · (2026) · View on PubMed ↗

Social and environmental determinants of dementia risk: An umbrella review.

This umbrella review synthesized evidence from systematic reviews (2004–2024) on how social and environmental determinants influence dementia risk, including Alzheimer’s disease, vascular dementia, and frontotemporal dementia. The key finding is that dementia risk is shaped by modifiable non-genetic factors, and the review organizes existing associations to clarify which social/environmental exposures have the strongest evidence. Clinically, it supports prevention-oriented strategies by highlighting actionable determinants that could complement biomedical risk reduction.

Ghiasvand S, Tegegne GT, Tabatabaei-Jafari H et al. · Journal of Alzheimer’s disease : JAD · (2026) · View on PubMed ↗

Insulin Signalling-Inducible IFITM1 Promotes Multiple Myeloma Progression and Bortezomib Resistance.

This study examined whether insulin-signalling–inducible interferon-induced transmembrane protein 1 (IFITM1) drives multiple myeloma (MM) progression and contributes to bortezomib resistance in patients and cancer models. IFITM1 (more than insulin receptor, INSR) was reported as significantly elevated in symptomatic MM versus MGUS and smouldering MM, and the abstract indicates IFITM1 is linked to poorer prognosis and bortezomib resistance (full correlation/prognostic details are truncated). Scientifically, it identifies the insulin–IFITM1 axis as a potential therapeutic target to overcome proteasome-inhibitor resistance in MM.

Lim JY, Kim Y, Park SS et al. · Journal of cellular and molecular medicine · (2026) · View on PubMed ↗ · Free PDF ↗

Inhibition of 5’-tiRNAGly restores anti-PD-1 immunotherapy efficacy via DLST-mediated OGDHL succinylation in gastric cancer.

This mechanistic study examined transfer RNA-derived small RNAs (tiRNAs), focusing on 5’-tiRNAGly, in gastric cancer (GC) patients and in models of anti–PD-1 immunotherapy response. It found that 5’-tiRNAGly is upregulated in non-responders, binds DLST to promote OGDHL destabilization, and that inhibiting 5’-tiRNAGly restores anti–PD-1 efficacy via the DLST-mediated OGDHL succinylation pathway. The significance is that 5’-tiRNAGly represents a potential predictive biomarker and therapeutic target to improve responses to anti–PD-1 therapy in GC.

Gu X, Zhang Y, Li Y et al. · Journal of experimental & clinical cancer research : CR · (2026) · View on PubMed ↗ · Free PDF ↗

Dual-target CAR-T cell therapy: latest updates from the 2025 ASH annual meeting.

This article summarized advances presented at the 2025 ASH annual meeting on dual-target CAR-T cell therapy across multiple disease areas. The key finding was that dual-target CAR-T designs—using varied receptor architectures, logic-gated strategies, and updated manufacturing platforms—show improved preclinical disease control and address antigen heterogeneity and antigen-negative escape compared with single-target approaches. The scientific significance is that these updates inform the next generation of CAR-T engineering strategies for B-cell malignancies, acute myeloid leukemia, and autoimmune disease models.

Feng S, Kong R, Xiao L et al. · Experimental hematology & oncology · (2026) · View on PubMed ↗ · Free PDF ↗

Pinocembrin, an anticancer dihydroxyflavanone: from chemistry to cellular interactions and synergistic prospects.

This article reviewed the anticancer dihydroxyflavanone pinocembrin (5,7-dihydroxyflavanone) and summarized evidence linking it to cellular interactions and synergistic therapeutic prospects across cancer models. The authors report that pinocembrin modulates multiple cancer hallmarks by regulating PI3K/Akt/mTOR, STAT3, and NF-κB signaling, producing antiproliferative, pro-apoptotic, anti-metastatic, and anti-inflammatory effects in diverse tumor contexts. This supports pinocembrin as a multi-target candidate for combination strategies, potentially helping overcome resistance in multiple cancer types.

Chane R, Saini S, Bhatia R et al. · Cancer cell international · (2026) · View on PubMed ↗ · Free PDF ↗

Late phase transfusion after CAR T therapy is associated with persistent hematotoxicity and non-relapse mortality in multiple myeloma: a post hoc analysis.

This post hoc analysis evaluated transfusion patterns after CAR T-cell therapy and their association with hematotoxicity and non-relapse mortality in multiple myeloma. In 155 relapsed/refractory multiple myeloma patients receiving CAR-T targeting different antigens, the study used multivariate regression and survival analyses to identify risk factors for early (≤30 days) versus late (>30 days) transfusion needs and assessed prognostic effects. It found that late-phase transfusion was associated with persistent hematotoxicity and higher non-relapse mortality, highlighting transfusion timing as a clinically informative marker after CAR T therapy.

Xia F, Lv B, Li X et al. · BMC medicine · (2026) · View on PubMed ↗ · Free PDF ↗

Fibronectin 1 mediates pressure-induced aggressive phenotypes in colorectal cancer cells and cancer stem cells.

This study examined how fibronectin 1 (FN1) mediates pressure-induced aggressive phenotypes in colorectal cancer cells and cancer stem cells, using an in vitro weight-induced compression model and a meta-analysis (PROSPERO: CRD42024571414). FN1 was identified as a key extracellular matrix mediator whose activity is linked to mechanical-pressure–driven colorectal cancer progression and more aggressive cancer-stem-like behavior. These findings suggest FN1 as a mechanobiology-relevant therapeutic target or biomarker for colorectal cancer patients whose tumors experience elevated mechanical stress.

Nguyen VC, Cheng KC, Phan TT et al. · Cancer cell international · (2026) · View on PubMed ↗ · Free PDF ↗

Circular RNAs in tumor biology and immunology: molecular mechanisms and therapeutic implications.

This 2026 review summarized how circular RNAs (circRNAs) function in tumor biology and immunology, including their molecular mechanisms and therapeutic potential in the immunosuppressive tumor microenvironment (TME). The key finding is that circRNAs are highly stable covalently closed RNAs that can regulate cancer hallmarks within tumor cells and can also be secreted to modulate antitumor immunity by reshaping the TME. Scientifically and clinically, circRNAs’ stability in body fluids supports their development as biomarkers and therapeutic targets for cancer immunotherapy.

Jiang Z, Peng Y, Yang X · Molecular cancer · (2026) · View on PubMed ↗ · Free PDF ↗

Paraneoplastic neurologic syndrome in advanced lung cancer with mixed adenocarcinoma and squamous features: a diagnostic challenge-a case report.

This case report described a 45-year-old Tanzanian male with advanced lung cancer (mixed adenocarcinoma and squamous features) presenting with paraneoplastic neurologic syndrome (PNS) symptoms including ageusia, dystonia, paresthesia, and ataxia. The key finding is that the neurologic presentation preceded or complicated cancer diagnosis, and tumor histologic heterogeneity across biopsy sites created a diagnostic challenge. Clinically, it highlights the need to consider PNS in atypical neurologic presentations and to account for NSCLC subtype variability when interpreting biopsy results.

Malangwa G, Mushengezi B, Lyatuu L et al. · Journal of medical case reports · (2026) · View on PubMed ↗ · Free PDF ↗

NNMT and the methylation sink: integrating metabolism, epigenetics and immunity in cancer.

This review studied nicotinamide N-methyltransferase (NNMT) and its “methylation sink” mechanism in cancer, integrating metabolism (SAM usage), epigenetics (methylation remodeling across DNA/RNA/proteins), and immunity across tumor and stromal lineages. It reports that NNMT is upregulated in multiple malignancies in both cancer cells and stromal cells such as cancer-associated fibroblasts and pericytes, and that NNMT activity correlates with cancer progression hallmarks including tumor growth and metastasis. The work is significant because it positions NNMT as a mechanistic bridge between metabolic reprogramming and epigenetic/immune remodeling, suggesting it as a potential therapeutic target or biomarker in oncology.

Li L, Ma Y, Pan Y et al. · BMC medicine · (2026) · View on PubMed ↗ · Free PDF ↗

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Cell therapy & regenerative medicine (MSC and beyond)

Mesenchymal Stem Cells Therapy for Intrauterine Adhesions and Endometriosis: Potential, Mechanisms, and Future Directions.

This review evaluated the potential mechanisms and future directions of mesenchymal stem cell (MSC) therapy for intrauterine adhesions (IUA) and endometriosis in the context of impaired endometrial regeneration, fibrosis, and chronic inflammation. It highlights that MSCs may improve outcomes by modulating aberrant fibrosis and inflammatory cascades and by promoting tissue repair, addressing limitations of current surgical adhesiolysis for IUA and hormonal suppression for endometriosis. The scientific significance is that MSC-based strategies could provide mechanism-targeted, regenerative therapies for infertility-associated gynecologic disease where standard treatments often fail.

Liu SH, He SY, Ji BQ et al. · FASEB journal : official publication of the Federation of American Societies for Experimental Biology · (2026) · View on PubMed ↗

Systemic mesenchymal stem cell therapy for reduction of inflammatory burden in a patient with juvenile-onset rheumatoid arthritis and dialysis-dependent renal failure.

This case report described systemic mesenchymal stem cell (MSC) therapy in a 56-year-old woman with juvenile-onset rheumatoid arthritis and dialysis-dependent renal failure. The key finding is that consecutive systemic MSC administration was used to reduce systemic inflammatory burden in a patient with limited options due to comorbid CKD and long-term hemodialysis. Clinically, it provides preliminary real-world evidence supporting MSC immunomodulation as a potential adjunct strategy for inflammation control in complex RA–end-stage renal disease patients.

Primorac D, Brlek P, Bulić L et al. · Croatian medical journal · (2026) · View on PubMed ↗

Restoring neuroplasticity after CNS trauma: cell therapy approaches in spinal cord and traumatic brain injury.

This review synthesized current cell therapy approaches intended to restore neuroplasticity after central nervous system trauma, focusing on spinal cord injury (SCI) and traumatic brain injury (TBI). It highlights how post-traumatic mechanisms—cell death, sustained inflammation, and inhibitory microenvironment formation—impair plasticity and regeneration, and it summarizes emerging cell-based strategies targeting these barriers. The work is significant for guiding translational development of therapies that improve functional recovery by modulating the post-injury neural environment.

Palha AT, Lima MF, Carvalho M et al. · Journal of translational medicine · (2026) · View on PubMed ↗ · Free PDF ↗

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Autophagy, mitophagy & organelle quality control

Lipid Codes and Lipid-Binding Proteins as Central Regulators of Autophagy.

This review studied how lipid molecules and lipid-binding proteins regulate autophagy, focusing on phosphoinositide microdomains and their kinases/phosphatases as spatial regulators of autophagy from phagophore nucleation to lysosomal degradation. It found that lipid composition and membrane physical properties coordinate multiple autophagy steps, including lysosome reformation, with additional contributions from sphingolipid/ceramide, phosphatidic acid/diacylglycerol metabolism, and fatty-acyl signaling. These mechanistic insights identify lipid pathways as potential targets to modulate autophagy in disease.

Kumar A, Ghosh DK · BioFactors (Oxford, England) · (2026) · View on PubMed ↗

MoCox6 is a potential fungicide target regulating mitophagy in magnaporthe oryzae.

This mechanistic study investigated MoCox6 as a potential fungicide target in the rice blast fungus Magnaporthe oryzae, focusing on how it regulates mitophagy. It found that outer mitochondrial membrane disruption exposes MoCox6 to interact with cytosolic MoAtg5 and MoAtg14 to drive mitophagy, while MoSirt5-mediated desuccinylation of MoCox6 at K144 weakens these interactions and restrains mitophagic flux, with Asp95 identified as a key residue at the MoSirt5–MoCox6 interface. These results are significant because they connect mitochondrial metabolic control to mitophagy and highlight MoCox6/MoSirt5 interactions as potential targets for antifungal development.

Wu MH, Zhu XM, Klionsky DJ et al. · Autophagy · (2026) · View on PubMed ↗

STING1 senses mitochondrial damage to promote mitophagy.

This mechanistic study investigated how the innate immune adaptor STING1 regulates selective autophagy (mitophagy) in response to mitochondrial damage, focusing on PINK1-PRKN-dependent pathways. The authors found that after mitochondrial injury, STING1 is recruited to damaged mitochondria and requires PINK1 and VCP/p97-mediated degradation of outer mitochondrial membrane proteins to drive PINK1-PRKN-dependent mitophagy. Clinically and scientifically, this links cGAS–STING1 signaling to organelle quality control, suggesting STING1 as a potential target to modulate mitophagy in diseases involving mitochondrial damage.

Huang ZB, Lin JY, Cheng LJ et al. · Autophagy · (2026) · View on PubMed ↗

Chrysin alleviates pressure overload-induced myocardial remodeling through regulating the PI3K/AKT/NRF2 pathway-mediated oxidative stress response.

This animal and cell study tested whether chrysin (CHR) protects against pressure overload–induced myocardial remodeling by modulating the PI3K/AKT/NRF2 oxidative stress pathway. Using transverse aortic constriction (TAC) in male C57BL/6J mice and angiotensin II (Ang II)–induced hypertrophy in H9C2 cells, the study reported CHR-mediated regulation of the PI3K/AKT/NRF2 axis to reduce oxidative stress and remodeling (specific results are truncated). The significance is that it identifies a mechanistic pathway for CHR’s cardioprotective potential in heart failure–related remodeling.

Wang Y, Feng X, Zhao S et al. · Animal models and experimental medicine · (2026) · View on PubMed ↗ · Free PDF ↗

α-tubulin N-acetyltransferase 1 regulates NCOA4-mediated ferritinophagy and protects cancer cells from ferroptosis.

This experimental study investigated how α-tubulin N-acetyltransferase 1 (ATAT1) regulates NCOA4-mediated ferritinophagy and protects cancer cells from ferroptosis. Using human cancer cell lines with ATAT1 knockdown (stable or transient silencing), the key finding was that loss of ATAT1 disrupts NCOA4-dependent ferritinophagy/iron homeostasis and alters susceptibility to ferroptosis, linking microtubule acetylation (α-tubulin K40 acetylation) to autophagy-iron death pathways. The clinical significance is that ATAT1 may represent a targetable regulator of ferroptosis sensitivity in cancer.

Pellegrini FR, Iuzzolino A, De Palma C et al. · Cellular & molecular biology letters · (2026) · View on PubMed ↗ · Free PDF ↗

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Innate immunity, inflammation & cytokine regulation

Identification of plaque psoriasis subgroups based on peripheral blood immune cells subtypes and their relationship with biologic therapy efficacy: a single-center longitudinal cohort study in China.

This single-center longitudinal retrospective cohort study analyzed peripheral blood immune-cell subtypes in 329 Chinese patients with plaque psoriasis initiating first-time biologic therapy and compared them with 169 healthy controls using hierarchical clustering of flow cytometry data. It identified distinct immunological psoriasis subgroups and linked these subgroups to differences in time to achieving PASI90, indicating subgroup-specific variation in biologic therapy efficacy. The findings suggest peripheral blood immune profiling could help stratify plaque psoriasis patients to improve personalized biologic treatment selection.

Liu R, Xie T, Zhao J et al. · Expert opinion on biological therapy · (2026) · View on PubMed ↗

E-cigarette aerosols induce the hydrolysis of lysosomal glycerophospholipids through PLA2G4A activation initiated by nicotine binding to CHRNA3/α3 nAchr in airway epithelial cells.

This study examined how e-cigarette aerosols affect airway epithelial cells, showing that nicotine triggers lysosomal glycerophospholipid hydrolysis via PLA2G4A activation initiated by nicotine binding to CHRNA3/α3 nAchr. It found that nicotine induced autophagosome formation through MTOR inhibition while simultaneously suppressing autolysosomal degradation via lysosomal membrane permeabilization (LMP), contributing to apoptosis, oxidative stress, and mucus overproduction in mouse airway epithelium and human bronchial epithelial cells. These findings are clinically significant because they identify a nicotine–CHRNA3/α3 nAchr–PLA2G4A–lysosomal lipid hydrolysis pathway that may underlie e-cigarette–associated airway injury.

Yu Y, Xu S, Yang L et al. · Autophagy · (2026) · View on PubMed ↗

[Expression and clinical significance of lymphocyte subsets in infectious pneumonia and immune-related interstitial lung disease].

This clinical study compared lymphocyte subset profiles among patients with infectious pneumonia versus immune-related interstitial lung disease (IRILD), including IRILD complicated by infection, to identify immune markers that differentiate pneumonia types. The key finding was that lymphocyte subset expression differed across these groups, supporting distinct immune status patterns that could be used for laboratory differentiation. The clinical significance is that immunophenotyping may improve diagnostic stratification between infectious pneumonia and IRILD phenotypes, including cases with superimposed infection.

Zhao D, Qi X, Huang B et al. · Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · (2026) · View on PubMed ↗

Integrative Multiomics and Network Pharmacology Exploration of Active Components and Mechanisms of Action of Qufu Shengxin Ointment in Treating Chronic Nonhealing Wounds.

This study investigated the molecular mechanisms of Qufu Shengxin Ointment (QFSO) for chronic nonhealing wounds (CNHWs) by integrating GEO transcriptomics with weighted gene co-expression network analysis (WGCNA) and network pharmacology. QFSO’s predicted active components and targets converged on CNHW-associated differentially expressed genes and co-expression modules, implicating pathways related to persistent inflammation and impaired autophagy. The work provides a systems-level hypothesis for how QFSO may modulate wound-healing biology and guides target-focused follow-up experiments.

Chen H, Li Y, Chen D et al. · Mediators of inflammation · (2026) · View on PubMed ↗ · Free PDF ↗

Integrated Blood Inflammatory Ratios and Cerebrospinal Fluid Blood‒Brain Barrier Dysfunction Predict Relapse Risk in Neuromyelitis Optica Spectrum Disorder.

This retrospective cohort study developed and internally validated an integrated relapse-risk prognostic model in 152 patients with neuromyelitis optica spectrum disorder (NMOSD) by combining blood inflammatory ratios with cerebrospinal fluid (CSF) measures of blood–brain barrier (BBB) dysfunction. The integrated model predicted relapse risk more effectively by capturing both systemic immune activation and BBB dysfunction, complementing AQP4-IgG–centered diagnosis. Scientifically, it provides a more individualized relapse stratification approach that could guide monitoring intensity and therapeutic decision-making.

Zheng X, Shi J, Yin H et al. · Brain and behavior · (2026) · View on PubMed ↗ · Free PDF ↗

The Prognostic Value of Serum Inflammatory Markers in Nasopharyngeal Carcinoma Patients Treated With Immune Checkpoint Inhibitors: A Multicenter Study.

This multicenter retrospective study assessed whether serum inflammatory markers measured before treatment can predict prognosis in nasopharyngeal carcinoma (NPC) patients receiving immune checkpoint inhibitors (ICIs) across three Chinese centers. The key finding was that specific baseline inflammatory hematologic parameters/derived inflammatory indices were associated with poorer outcomes, supporting their prognostic value in ICI-treated NPC. This could enable risk stratification using routinely available blood tests to better tailor follow-up and therapeutic decisions.

Xu Y, Xie J, Zhang D et al. · Cancer medicine · (2026) · View on PubMed ↗ · Free PDF ↗

Lactate-Associated Gene Signatures as Predictors: A Comprehensive Analysis of Immune Profiles in Sepsis.

This study analyzed publicly available sepsis RNA-seq datasets from GEO to identify lactylation-associated gene signatures and immune-profile predictors of sepsis using differential expression and Mendelian randomization approaches. The key finding is that integrating lactylation-related genes with sepsis differentially expressed genes yields sepsis-related differentially expressed lactylation-related genes (Sepsis-DELRGs) that can stratify sepsis and link lactate/lactylation biology to immune dysregulation. Scientifically, it supports lactate-driven lactylation as a mechanistic regulator of immune responses in sepsis and suggests gene signatures for risk prediction and potential therapeutic targeting.

Yan L, Han Y, Tong C · Journal of intensive care medicine · (2026) · View on PubMed ↗

The dual balance of the cytokine network: key messengers of immune activation and triggers of cytokine storm.

This review article examined how the immune cytokine network maintains balance between pro-inflammatory and anti-inflammatory cytokines through positive and negative feedback loops in physiological and pathological contexts. It found that the dynamic “dual balance” of cytokine signaling determines the intensity and duration of immune activation and can tip toward dysregulated cytokine storm when homeostasis fails. The synthesis is significant because it provides a mechanistic framework for identifying biomarkers and therapeutic targets to prevent or mitigate cytokine storm–associated diseases.

Zhang Y, Guo D, Zhou Y et al. · Biomarker research · (2026) · View on PubMed ↗ · Free PDF ↗

The cGAS-STING pathway contributes to cisplatin-induced skeletal muscle atrophy through altered proteostasis and myogenic signaling.

The study investigated whether the cGAS-STING innate immune pathway contributes to cisplatin-induced skeletal muscle atrophy by altering proteostasis and myogenic signaling in vivo. Using wild-type mice treated with cisplatin and combining pharmacological and genetic approaches (details truncated in the abstract), the authors tested cGAS-STING involvement in muscle atrophy mechanisms. Establishing a causal role for cGAS-STING would identify a mechanistic target to mitigate chemotherapy-associated muscle wasting and preserve patient function.

Liu X, Xu M, Wang H et al. · Cell communication and signaling : CCS · (2026) · View on PubMed ↗ · Free PDF ↗

Macrophage immunometabolism in stroke: a view from single-cell and nano technologies.

This 2026 review synthesized single-cell and nano-technology evidence on macrophage immunometabolism in stroke, emphasizing that post-stroke macrophage states extend beyond the simplistic M1/M2 paradigm. The key finding is that single-cell RNA sequencing reveals dynamic macrophage heterogeneity with distinct metabolic programs, including an LCP1+ population linked to coupled glycolipid metabolism. Scientifically, this reframes stroke immunology around metabolic phenotypes and supports targeting specific macrophage metabolic states to improve outcomes.

Zhu Y, Huang Z, Li X et al. · Journal of translational medicine · (2026) · View on PubMed ↗ · Free PDF ↗

Clinical features, outcome and HLA subtypes in Eastern patients with anti-IgLON5 disease: a multicenter study.

This multicenter retrospective study characterized clinical features, treatment response, relapse, and long-term outcomes of anti-IgLON5 disease in Eastern (Chinese) patients and assessed HLA subtypes. The key finding is that anti-IgLON5 disease in this cohort was systematically linked to measurable clinical outcomes (mRS/ICS), treatment response patterns, and HLA-defined immunogenetic variation. This supports improved prognostication and potentially more tailored management for anti-IgLON5 disease in Eastern populations.

Gao Y, Sun X, Zhou Y et al. · Orphanet journal of rare diseases · (2026) · View on PubMed ↗ · Free PDF ↗

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Microbiome & host-microbe interactions

[Association between wearable-derived physical activity patterns and gut microbiota in older adults].

This study examined how wearable-derived physical activity patterns (mean daily steps, step variability, and proportion of active days over 180 days) relate to gut microbiota composition in 743 older adults from Eastern, Central, and Northern China. Using fecal 16S rRNA gene sequencing (V3 region) and statistical association analyses, distinct real-world activity patterns were linked to differences in gut microbiota composition. These findings support using objective wearable activity phenotyping to identify older adults whose microbiome may be more vulnerable to metabolic or inflammatory risk.

Gao J, Li W, Li X et al. · Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · (2026) · View on PubMed ↗

Faecal Microbiota Transplantation Reduces Lesion Severity and Medication Use in Canine Atopic Dermatitis: A Randomised, Placebo-Controlled, Double-Blinded Clinical Trial.

This randomized, placebo-controlled, double-blinded clinical trial studied adjunctive faecal microbiota transplantation (FMT) in 46 client-owned dogs with naturally occurring canine atopic dermatitis (cAD), with 40 completing the study (FMT n=20, placebo n=20). Dogs receiving daily oral lyophilised FMT capsules had reduced lesion severity and used less symptomatic medication than placebo. These findings support FMT as a potentially effective and safe microbiome-based adjunct therapy for cAD in veterinary practice.

Felten V, West EA, Martini F et al. · Veterinary dermatology · (2026) · View on PubMed ↗ · Free PDF ↗

Probiotics in allergic disease: from adjunct supplement to immune-modifying strategy (2026 update).

This 2026 update review summarized evidence on how probiotics act as immune-modifying strategies in allergic disease, emphasizing translational findings from 2024–2026. The review highlights strain-specific expansion of Foxp3+ regulatory T cells, reduced Th2 polarization, improved epithelial barrier integrity, and durable epigenetic stabilization via short-chain fatty acids such as butyrate, with clinical trial support for perinatal prevention of atopic dermatitis. Scientifically and clinically, it supports selecting specific probiotic strains and timing (e.g., early-life/perinatal windows) to enhance immune tolerance and reduce allergic disease risk.

Raho GS · Current opinion in allergy and clinical immunology · (2026) · View on PubMed ↗

Resolving the Unresolvable: Nanopore Sequencing as a Comprehensive Quality Control Platform for Gene Therapy Vectors.

This review evaluated Oxford Nanopore Technologies long-read, native single-molecule sequencing as a comprehensive quality control (QC) platform for gene therapy vectors across the manufacturing lifecycle. The key finding is that nanopore sequencing can resolve complex vector structures that legacy assays (Sanger and short-read NGS) often miss, including AAV inverted terminal repeats, lentiviral recombination events, and mRNA poly(A) tail features. Scientifically and clinically, it supports improved vector characterization and release testing for cell and gene therapy manufacturing by reducing “black box” uncertainty in QC.

Xu Y, Zhang XB, Zhang JP · Human gene therapy · (2026) · View on PubMed ↗

Diet and microbiome shape small-molecule cytokinin pools in mammals.

This study used integrated metabolomics, microbiome profiling, and metagenomics to characterize cytokinin (CK) metabolite pools in mammals and identify potential sources of CKs. Serum profiling across five animal species detected multiple CK derivatives, with the storage form zeatin-O-glucoside predominating and the overall CK composition differing from plant tissue (species-specific differences are truncated). The scientific significance is that it links diet/microbiome and host metabolism to mammalian CK availability, reframing CKs as metabolites with potential roles in mammalian physiology.

Othman EM, Bencurova E, Ferretti P et al. · Gut microbes · (2026) · View on PubMed ↗ · Free PDF ↗

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Neurodegeneration & dementia biomarkers/mechanisms

Decoding the neuroprotective secrets of Tinospora sinensis: navigating the rotenone induced storm of behavioral and biochemical challenges in Parkinson’s disease rat models.

This preclinical study investigated Tinospora sinensis stem extract (TSSE) in rats with rotenone-induced Parkinson’s disease, using behavioral tests (catalepsy, locomotor activity, rotarod) and biochemical assays, with levodopa-carbidopa as the reference treatment. TSSE administration at 100, 200, and 400 mg/kg mitigated rotenone-associated behavioral deficits and improved related biochemical outcomes compared with untreated PD model rats. The results suggest TSSE may have neuroprotective potential via antioxidant/anti-stress mechanisms relevant to Parkinson’s disease models.

Bhong P, Ingale S, Jadhav P · Journal of complementary & integrative medicine · (2026) · View on PubMed ↗ · Free PDF ↗

A mechanistic framework linking the oral microbiome to Alzheimer’s disease through neuroinflammation.

This review proposed a mechanistic framework linking the oral microbiome to Alzheimer’s disease (AD) via neuroinflammation, integrating evidence from human observations and animal models. The key finding is that specific oral microbes (e.g., Porphyromonas gingivalis and Candida albicans) have been detected in AD brains, and mouse studies suggest oral microbes can cross the blood-brain barrier and correlate with AD-related pathology and inflammatory processes. Scientifically, it strengthens the rationale for targeting oral dysbiosis to modulate neuroinflammation and potentially influence AD progression.

Evers MJAP, Krom BP, de Jongh CA · Journal of Alzheimer’s disease : JAD · (2026) · View on PubMed ↗ · Free PDF ↗

Circadian gatekeepers of the gut-brain-immune axis: implications for neuroinflammation and neurodegeneration.

This 2026 review synthesized evidence on circadian rhythms as regulators of the gut-brain-immune axis, focusing on mechanisms linking circadian-gut microbiota interactions to neuroinflammation and neurodegeneration. The key finding is that bidirectional coupling between circadian clocks and gut microbiota can reshape peripheral and central immune signaling, thereby influencing neuroinflammatory pathways relevant to neurodegenerative disease progression. Clinically, the review supports targeting circadian–microbiome pathways as a potential strategy to modify neuroinflammation risk and progression in neurodegenerative disorders.

Cheng WY, Chan PL, Chan MK et al. · Journal of neuroinflammation · (2026) · View on PubMed ↗ · Free PDF ↗

Estimation of positron emission tomography amyloid load and related biomarkers in Alzheimer’s disease using evoked potential tomography EEG: development and internal validation in a cross-sectional cohort.

This study developed and internally validated an EEG-based Evoked Potential Tomography (EPT) approach using a novel visual evoked potential protocol to estimate Alzheimer’s disease (AD) biomarkers in a cross-sectional cohort. The key finding was that the automated pipeline (EEG preprocessing, ERP extraction, feature selection, regression modeling) could estimate PET-amyloid standardized uptake value ratio (SUVR) and CSF phosphorylated tau (p-tau181) as well as cognitive measures (FCSRT and Mini-Mental State Examination). This provides a more portable, non-PET/non-CSF method for multi-biomarker assessment in AD, potentially enabling earlier detection and monitoring.

Rauchmann BS, Hamet J, Lai J et al. · Alzheimer’s research & therapy · (2026) · View on PubMed ↗ · Free PDF ↗

Natural history and 12-month progression of multiple system atrophy in a Chinese cohort.

This observational 12-month natural history study investigated progression in a Chinese cohort of multiple system atrophy (MSA), enrolling participants with possible or probable MSA-P or MSA-C subtypes and analyzing Total UMSARS (Parts I+II) over baseline, Month 6, and Month 12. The key finding was characterization of early MSA progression trajectories using a linear mixed model, quantifying how symptoms worsen over the first year in this population. The significance is that these real-world progression estimates can inform prognosis counseling and the design of future interventional trials targeting early MSA.

Feng T, Wang H, Wang J et al. · BMC neurology · (2026) · View on PubMed ↗ · Free PDF ↗

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Neuroinflammation & neuroimmune cell regulation

C1q-CD44 interactions regulate microglial phagocytosis, proliferation, and migration.

This study examined how complement protein C1q interacts with CD44 to regulate microglial phagocytosis, proliferation, and migration, using human induced pluripotent stem cell–derived microglia (iMG) and related experimental approaches. The key finding was that C1q–CD44 signaling modulates microglial functional behaviors central to neurodegeneration responses, including phagocytosis and movement. The significance is that it identifies a specific molecular interaction axis (C1q–CD44) that could be targeted to influence microglial activity in neuroinflammatory and neurodegenerative diseases.

Sakthivel PS, Villegas AJ, Lakatos A et al. · Journal of neuroinflammation · (2026) · View on PubMed ↗

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Cardiometabolic disease, risk, and biomarkers

Socioeconomic Factors and Their Role in Metabolic Dysfunction-Associated Steatotic Liver Disease: A Comprehensive Review.

This comprehensive review synthesized evidence on how socioeconomic factors (e.g., income, poverty, food insecurity, health insurance, education, migration, and composite indices) relate to metabolic dysfunction-associated steatotic liver disease (MASLD) prevalence, severity, and outcomes across regions. Overall, multiple socioeconomic determinants were repeatedly associated with increased MASLD risk and worse disease outcomes, acting as upstream drivers through lifestyle and healthcare-access pathways. The review underscores the need to incorporate social determinants of health into MASLD prevention and risk-reduction strategies.

Wiering L, Demir M · Liver international : official journal of the International Association for the Study of the Liver · (2026) · View on PubMed ↗ · Free PDF ↗

Predicting major adverse cardiovascular and cerebrovascular events in chronic heart failure: a machine learning study.

This retrospective machine-learning study evaluated how baseline clinical data can predict major adverse cardiovascular and cerebrovascular events (MACCE) in 271 patients with chronic heart failure, using training and testing cohorts. The key result was the development and validation of an ML prediction model that identified the most informative baseline features for MACCE risk stratification. If externally validated, the model could improve early identification of high-risk heart failure patients and guide closer monitoring or preventive interventions.

Feng S, Fan B, Bai J et al. · Annals of medicine · (2026) · View on PubMed ↗ · Free PDF ↗

The changing epidemiology of human type 2 diabetes-associated atherosclerosis: Pathophysiological mechanisms and emerging treatment possibilities.

This review synthesized evidence on the epidemiology and pathophysiological mechanisms of type 2 diabetes (T2D)-associated atherosclerosis and discussed emerging treatment possibilities targeting processes beyond conventional lipid-lowering and inflammation control. The key finding is that, despite declines in overall cardiovascular events, people with T2D still have roughly double the risk of macrovascular complications compared with those without diabetes, indicating persistent T2D-specific atherogenic biology. Clinically, it highlights the need to identify actionable biological processes unique to T2D-associated atherosclerosis to develop more effective, mechanism-based therapies.

Al-Sharify D, Sun J, Edsfeldt A · Journal of internal medicine · (2026) · View on PubMed ↗ · Free PDF ↗

Causal effects of 32 eating habits on ischemic stroke risk and post-stroke functional outcome: A Mendelian randomization study.

This two-sample Mendelian randomization study assessed causal effects of genetically predicted intake of 32 eating habits on ischemic stroke risk and post-stroke functional outcomes using European-ancestry GWAS summary statistics. After multiple-testing correction, the abstract indicates specific dietary exposures (e.g., higher genetically predicted cheese intake) were evaluated for stroke risk and functional outcomes, with sensitivity analyses for pleiotropy and multivariable MR for mediation via lipids and blood pressure (key significant results are truncated). Clinically, it aims to prioritize dietary factors with causal relevance to ischemic stroke prevention and recovery.

Xu X, Zang X, Liu H et al. · The Journal of international medical research · (2026) · View on PubMed ↗ · Free PDF ↗

Liver sinusoidal endothelial cell fenestrations in metabolic liver disease: from molecular mechanisms to therapeutic perspectives.

This review article examined the role of liver sinusoidal endothelial cell (LSEC) fenestrations in metabolic liver disease, focusing on molecular mechanisms driving capillarization (loss of fenestrations) in MASLD and MASH. The key finding was that progressive impairment of LSEC fenestrations disrupts signaling balance between pro-fenestration and pro-capillarization pathways, thereby promoting disease progression. The scientific significance is that it frames the “LSEC Fenestration Signaling Nexus” as a therapeutic opportunity for restoring vascular function in metabolic liver disease.

Al-Mughalles AS, Ma J, Ma H et al. · Cell communication and signaling : CCS · (2026) · View on PubMed ↗ · Free PDF ↗

Endothelial glycocalyx perturbation in obstructive sleep apnea is associated with repetitive hypoxemia and immunothrombotic endothelial dysfunction.

This observational human study examined whether endothelial glycocalyx (eGCX) perturbation in obstructive sleep apnea (OSA) is linked to repetitive hypoxemia and immunothrombotic endothelial dysfunction. In prospectively recruited men (n=60) undergoing polysomnography, the authors related OSA severity metrics (AHI, ODI, hypoxic burden) to plasma biomarkers of eGCX components—hyaluronan (HA), heparan sulfate (HS), and syndecan-1 (SDC-1)—from single-time-point sampling. The findings support a mechanistic link between intermittent hypoxia in OSA, glycocalyx damage, and endothelial dysfunction relevant to cardiovascular risk.

Müller MB, Kammerer T, Khan H et al. · Journal of translational medicine · (2026) · View on PubMed ↗ · Free PDF ↗

The effect of empagliflozin on inflammation in patients with overweight or obesity and risk of heart failure: a substudy from the Empire Prevent Metabolic trial.

This pre-specified secondary analysis from the Empire Prevent Metabolic trial evaluated whether the SGLT2 inhibitor empagliflozin reduces systemic inflammation, uric acid, and adipose tissue dysfunction in outpatients with overweight or obesity (BMI > 28 kg/m2) at high risk for heart failure. The key finding (as framed by the study aim) is that empagliflozin was tested for anti-inflammatory and adipose-functional effects in a population without diabetes and without established heart failure, addressing a major evidence gap. If effective, these results would support SGLT2 inhibitor–mediated immunometabolic mechanisms as a preventive strategy for heart failure risk in obesity-related inflammation.

Andersen CF, Larsen JH, Omar M et al. · Cardiovascular diabetology · (2026) · View on PubMed ↗ · Free PDF ↗

Growth differentiation factor-15 and the incidence, bidirectional progression, and risk prediction of atherosclerotic cardiovascular disease and metabolic dysfunction-associated steatotic liver disease in individuals with cardiovascular-kidney-metabolic syndrome stages 0-3.

This UK Biobank study assessed whether growth differentiation factor-15 (GDF-15) predicts incidence, bidirectional progression, and risk of atherosclerotic cardiovascular disease (ASCVD) and metabolic dysfunction–associated steatotic liver disease (MASLD) across cardiovascular-kidney-metabolic (CKM) syndrome stages 0–3. The key finding is that GDF-15 was analyzed for associations with metabolic/inflammatory/liver fibrosis markers and CKM stage using regression models and competing-risk Fine-Gray models for incident ASCVD (and related outcomes). Clinically, it positions GDF-15 as a potential integrative biomarker for risk stratification and progression tracking in CKM patients at early-to-intermediate stages.

Chen X, Tang H, Xu Z et al. · Cardiovascular diabetology · (2026) · View on PubMed ↗ · Free PDF ↗

Integrating inflammation, insulin resistance, and visceral adiposity: the C-reactive protein-triglyceride-glucose-Chinese visceral adiposity (CTI-CVAI) index is associated with cardiovascular disease risk across CKM stages 0-3 in a nationwide prospective cohort.

This nationwide prospective cohort study evaluated the association of the C-reactive protein–triglyceride–glucose–Chinese visceral adiposity (CTI-CVAI) index with incident cardiovascular disease across cardiovascular-kidney-metabolic (CKM) stages 0–3 in Chinese adults. The key finding was that a higher CTI-CVAI index was associated with greater CVD risk and improved prediction of incident CVD compared with biomarkers that do not integrate inflammation, insulin resistance, and visceral adiposity. Scientifically and clinically, the CTI-CVAI index may enable earlier risk stratification and prevention strategies for people in early CKM stages.

Wang Q, Li J, Qiao H et al. · Cardiovascular diabetology · (2026) · View on PubMed ↗ · Free PDF ↗

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Diabetes, obesity & metabolic pharmacology

Challenge of diagnosing celiac disease in pediatric type 1 diabetes mellitus: lessons from long-term serological surveillance.

This 12-year retrospective single-center cohort study evaluated celiac disease (CD) screening and diagnostic thresholds for tTG-IgA in 282 children with newly diagnosed type 1 diabetes mellitus (T1DM) in Türkiye. Long-term serological surveillance showed that CD can be missed without adequate screening frequency and that optimal tTG-IgA thresholds depend on the screening context and timing. The findings inform more effective pediatric T1DM CD screening strategies to reduce delayed or missed CD diagnosis.

Teke S, Tuna Kırsaclıoglu C, Turk NE et al. · Postgraduate medicine · (2026) · View on PubMed ↗

Evidence-informed guidance for the clinical use of oral semaglutide in obesity management.

This evidence-informed guidance article reviewed clinical use of oral semaglutide for obesity management in adults, focusing on how to individualize therapy and optimize administration for absorption. The key finding is that oral semaglutide (a GLP-1 receptor agonist) produces weight loss comparable to subcutaneous GLP-1 therapies and improves cardiometabolic risk factors, but requires specific dosing conditions to achieve effective exposure. Clinically, the guidance supports safer, more effective prescribing by aligning patient preferences and real-world administration practices with the drug’s pharmacokinetic requirements.

Rubino D, Wharton S, Knight MG et al. · Postgraduate medicine · (2026) · View on PubMed ↗ · Free PDF ↗

Bioelectric Reawakening by a Self-Powered Thermoelectric Hydrogel Accelerates Diabetic Ulcer Repair.

This preclinical study developed a self-powered ionic thermoelectric dual-network hydrogel to treat diabetic foot ulcers (DFUs) by restoring wound bioelectricity and modulating the DFU microenvironment. The hydrogel generated wound-relevant microcurrents under physiological temperature gradients and incorporated luteolin to further remodel the hostile ulcer environment, accelerating diabetic ulcer repair. The approach is scientifically significant because it combines passive thermoelectric bioelectric reactivation with anti-inflammatory/antioxidant bioactivity to address multiple barriers to DFU healing.

Luo W, Zhang S, Sun H et al. · Advanced materials (Deerfield Beach, Fla.) · (2026) · View on PubMed ↗

m6A-modified ATF4 regulates glucose/lipid metabolism via the Sestrin2/GSK3β axis to alleviate myocardial ischemia-reperfusion injury.

This study investigated how m6A-modified ATF4 regulates glucose/lipid metabolism through the Sestrin2/GSK3β axis to alleviate myocardial ischemia-reperfusion injury (MIRI) using bioinformatics and a hypoxia/reoxygenation (H/R) model in HL-1 cardiomyocytes. The key finding was that ATF4 knockdown (via RNA interference) modulates metabolic pathways through the Sestrin2/GSK3β signaling axis in the context of MIRI, implicating m6A regulation of ATF4 as a functional driver. The clinical significance is that targeting the m6A–ATF4–Sestrin2/GSK3β pathway could represent a therapeutic strategy to reduce MIRI-related metabolic dysfunction.

Wu J, Tong J, Zhang F et al. · Journal of cardiothoracic surgery · (2026) · View on PubMed ↗ · Free PDF ↗

Trends and disparities in glycemic control and severe hyperglycemia in U.S. adults with diabetes mellitus before and during COVID-19 pandemic.

This retrospective cohort study examined trends in glycemic control (HbA1c <7%) and severe hyperglycemia (HbA1c >10%) among U.S. adults with diagnosed diabetes before and during the COVID-19 pandemic using NHANES data. The key finding was that glycemic control and the prevalence of severe hyperglycemia changed across the pre-pandemic (Jan 2017–Mar 2020) versus pandemic (Aug 2021–Aug 2023) periods, with differences by age and race/ethnicity and socioeconomic factors (as assessed in the study). Clinically, the results highlight pandemic-era disparities in diabetes outcomes and support targeted public health and care-delivery interventions to reduce severe hyperglycemia risk.

Wang L, Song L, Fan J · Nutrition & metabolism · (2026) · View on PubMed ↗ · Free PDF ↗

Boerhaave’s syndrome associated with glucagon-like peptide-1 receptor agonist use: a case report.

This case report studied a woman in her 50s with type 2 diabetes/weight-loss treatment context who developed Boerhaave’s syndrome after glucagon-like peptide-1 receptor agonist (GLP-1 RA) use, emphasizing the role of abrupt reinitiation at high doses. The key finding was that GLP-1 RA–associated vomiting/retching in the setting of high-dose restart was temporally linked to full-thickness esophageal perforation with life-threatening shock. The clinical significance is that clinicians should recognize rare but fatal esophageal complications after GLP-1 RA reinitiation and consider dose-escalation and risk mitigation strategies.

Aubrey JM, Benner C, Lam GT · Journal of cardiothoracic surgery · (2026) · View on PubMed ↗ · Free PDF ↗

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Cardiovascular pharmacology, drug interactions & perioperative risk

Three-Dimensional Portal Vein Geometry Predicts Post-TIPS -Hepatic Encephalopathy and Variceal Rebleeding: A Multicenter Study.

This multicenter retrospective study assessed whether preoperative three-dimensional portal vein geometry features from routine CT angiography predict 1-year post-TIPS overt hepatic encephalopathy (OHE) and variceal rebleeding (VRB) in 579 cirrhotic patients undergoing TIPS. Specific 3D portal venous geometry metrics—such as bifurcation angles and vessel tortuosity—were associated with higher relapse risk, supporting 3D-PVG as an independent prognostic biomarker. Clinically, incorporating 3D-PVG into pre-TIPS risk stratification could improve individualized monitoring and management to reduce OHE and VRB.

Wan S, Li J, Zhang X et al. · Liver international : official journal of the International Association for the Study of the Liver · (2026) · View on PubMed ↗

Impact of Hypothyroidism on Short-Term and Long-Term Outcomes of Coronary Artery Bypass Graft Surgery.

This retrospective longitudinal analysis evaluated CABG incidence and short- and long-term outcomes in patients with hypothyroidism receiving thyroid hormone replacement, and tested whether abnormal preoperative TSH modifies surgical risk. Compared with patients without thyroid disease, hypothyroidism was associated with differences in postoperative outcomes after CABG, and preoperative TSH abnormalities further stratified risk. These results suggest thyroid status and TSH level may be important perioperative risk modifiers in CABG patients.

Meneghini V, Beltrão FEL, Ismail A et al. · Thyroid : official journal of the American Thyroid Association · (2026) · View on PubMed ↗

Radiotherapy and Cardiovascular Disease Survival Risk in Non-Small Cell Lung Cancer: A Population-Based Study From the Surveillance, Epidemiology, and End Results Database.

This population-based SEER analysis studied whether radiotherapy affects cardiovascular disease survival risk in 89,569 adults with non-small cell lung cancer (NSCLC) aged ≥18 years. Using multivariate Cox proportional hazards models with cardiovascular-specific death as an endpoint, the analysis did not identify a significant effect of radiotherapy on cardiovascular survival risk. If confirmed, these findings suggest that—at the population level—radiotherapy may not independently worsen cardiovascular-specific survival in NSCLC, though treatment details and confounding still warrant careful interpretation.

Liu L, Fan C, Ren W et al. · Cancer medicine · (2026) · View on PubMed ↗ · Free PDF ↗

Haematological and Oncological Training Therapy With Stationary Strength and Cardio Machines (HOT) in Routine Cancer Care: A 3-Year Real-World Evaluation of Acceptance, Feasibility, Safety, and Effects.

This 3-year real-world evaluation assessed acceptance, feasibility, safety, and effects of Haematological and Oncological Training Therapy with Stationary Strength and Cardio Machines (HOT) in routine cancer care in Germany. HOT delivered 24 combined resistance and aerobic sessions (plus a sensorimotor module for chemotherapy-induced peripheral neuropathy, CIPN) and was evaluated for program uptake and patient outcomes over three years. The study is clinically relevant because it supports the practicality and potential benefits of structured, donation-funded exercise programming within routine oncology services.

Felser S, Engel M, Grosse-Thie C et al. · Cancer medicine · (2026) · View on PubMed ↗ · Free PDF ↗

Biased signaling of β2-adrenergic receptor in physiological and pathological states.

This review studied biased signaling mechanisms of the β2-adrenergic receptor (β2AR) in physiological versus pathological states, focusing on how ligand binding preferentially activates specific downstream pathways. The key finding is that β2AR can signal through biased activation of pathways such as β-arrestin, ERK1/2, and PI3K/Akt depending on the engaged G protein and ligand context, producing distinct cellular outcomes. The scientific significance is that understanding β2AR biased signaling can guide more precise drug development for cardiovascular and respiratory diseases where β2AR signaling is implicated.

Xu Y, Kawuribi V, Adu-Amankwaah J et al. · Cellular & molecular biology letters · (2026) · View on PubMed ↗ · Free PDF ↗

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Genetics, genomics & multi-omics (including sequencing/QC)

Single-Sequence Deep Learning Delivers Crystal-Quality Models of Covalent K-Ras G12 Hotspot Complexes.

This computational study evaluated whether the structure prediction tool Chai-1 can generate crystal-quality models of covalent K-Ras(G12C) hotspot complexes without using multiple sequence alignment (MSA). It found that Chai-1 accurately predicts covalent K-Ras(G12C) complexes with pocket-aligned RMSDs <2 Å across chemically diverse inhibitors. This is significant for accelerating structure-based design of covalent K-Ras(G12C) drugs by reducing reliance on time-consuming experimental co-complex structures.

Jung S, Zheng Q, Shokat KM · IUBMB life · (2026) · View on PubMed ↗

Bone and Radiologic Findings in Congenital Generalized Lipodystrophy: A Systematic Review and Report of 60 Cases.

This systematic review and case series evaluated bone and radiologic manifestations in congenital generalized lipodystrophy (CGL), specifically focusing on patients with pathogenic variants in AGPAT2 (CGL1) and BSCL2 (CGL2). The key finding is that CGL is associated with characteristic skeletal abnormalities such as diffuse sclerosis, lytic-appearing bone lesions, and high bone mineral density, but the prevalence and detailed radiologic phenotype distribution across CGL1 versus CGL2 had been insufficiently defined. Clinically, the synthesis of 60 cases aims to improve recognition, risk stratification, and management of bone complications in CGL patients.

Dyer MM, Tuska RM, Brush MN et al. · Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · (2026) · View on PubMed ↗ · Free PDF ↗

Optimizing Research Operations and Resource Utilization in ALS Care: Insights From the Tofersen Antisense Oligonucleotide Expanded Access Protocol.

This article described real-world clinical and operational experience administering tofersen, an antisense oligonucleotide targeting SOD1, through the U.S. FDA expanded access protocol in symptomatic SOD1(+) amyotrophic lateral sclerosis (ALS) patients. The key finding was that tofersen was delivered via bedside lumbar punctures at a single academic center (Massachusetts General Hospital) with documented operational approaches for single-patient and intermediate dosing logistics (full operational outcomes are truncated). Scientifically and clinically, it provides implementation insights that can streamline access and delivery of gene-targeted therapies for SOD1(+) ALS outside traditional trials.

Wheeler A, Mehta K, Sanders D et al. · Muscle & nerve · (2026) · View on PubMed ↗

Enhancers integrate microenvironmental signals in muscle stem cells during regeneration in health, disease, and aging.

This perspective/review examined how transcriptional enhancers integrate microenvironmental signals in muscle stem cells (MuSCs) during regeneration across health, disease, and aging. The key finding is that niche-derived cues (inflammatory, extracellular matrix, paracrine, metabolic, biomechanical) are translated into gene-expression programs through enhancer regulation coordinated by lineage-defining transcription factors and chromatin/histone mechanisms (details truncated). Scientifically, it highlights enhancers as a regulatory interface that could be targeted to improve muscle regeneration in aging and disease.

Hachmer S, Dilworth FJ · Skeletal muscle · (2026) · View on PubMed ↗ · Free PDF ↗

Glycoproteomic and genetic analysis of N-glycosylation of complement component C3 reveals immune pathway regulation.

This study combined population-scale glycoproteomics with genome-wide association analysis (GWAS) to identify genetic regulators of N-glycosylation in complement component C3. Using LC-MS glycopeptide analysis of 816 Croatian adults, it characterized N-glycosylation at C3 sites N63 and N917 as predominantly exclusive high-mannose structures, and GWAS identified genetic loci associated with site-specific glycosylation (specific loci are truncated). The significance is that it links human genetic variation to complement C3 glycosylation and immune pathway regulation, informing how immune function may differ across populations.

Šoić D, Rudman N, Grant OC et al. · Genome biology · (2026) · View on PubMed ↗ · Free PDF ↗

Rethinking EDSS-based ambulation assessment in multiple sclerosis using continuous variable monitoring.

This prospective observational study evaluated continuous variable monitoring of real-world walking performance in relapsing-remitting multiple sclerosis (RRMS) patients at two German centers, comparing it with Expanded Disability Status Scale (EDSS)-based ambulation assessments at baseline and study completion. The key finding was that EDSS, which relies on single discrete patient-estimated walking ability, may be less objective than digital health technology (DHT) approaches that capture continuous walking metrics. Clinically, this supports rethinking EDSS-based ambulation measurement to improve accuracy and sensitivity for tracking functional disability progression in MS.

Werner NM, Schuette M, Hagler R et al. · Neurological research and practice · (2026) · View on PubMed ↗ · Free PDF ↗

CRISPR mediated PRRS resistant pigs: biological success, welfare implications, and ethical regulatory challenges for sustainable swine production.

This study investigated genome-edited pigs engineered for resistance to porcine reproductive and respiratory syndrome (PRRS) by targeting the host gene CD163 using CRISPR-mediated editing, assessing biological success alongside welfare and regulatory implications. The key finding was that CD163 editing can provide host-directed resistance against PRRS while introducing new considerations for animal welfare and ethical/oversight challenges for sustainable swine production. Scientifically and clinically, it highlights CRISPR-based host resistance as a potential complement to vaccination and biosecurity, but underscores the need for robust governance frameworks.

Khan S, Korai Z, Korai SK et al. · Porcine health management · (2026) · View on PubMed ↗ · Free PDF ↗

IDMME and IDMDE: inducible CRISPR-dCasRx platforms for spatiotemporal RNA m5C editing.

The study developed abscisic acid (ABA)-inducible CRISPR-dCasRx platforms (IDMME for methylation and IDMDE for demethylation) to enable programmable RNA N5-methylcytosine (m5C) editing in renal carcinoma models. The ligand-dependent split-effector assembly produced site-specific, low off-target m5C editing, and photocaged ABA enabled light-controlled activation, with targeted m5C editing altering transcript function and suppressing tumor growth in vitro and in vivo. This provides a reversible, spatiotemporally controllable RNA epigenome editing tool with therapeutic potential for cancer by directly tuning m5C-regulated RNA function.

Xu J, Xu J, Cao C et al. · Genome biology · (2026) · View on PubMed ↗ · Free PDF ↗

Cross-trait mapping of shared susceptibility across inflammatory bowel disease and spondyloarthropathies.

The study performed cross-trait genetic mapping of shared susceptibility between inflammatory bowel disease (IBD)—including Crohn’s disease and ulcerative colitis—and spondyloarthropathies (SpAs) using European-ancestry GWAS summary statistics. By integrating 22.21 million variants across 1,263,767 individuals and applying genome-wide/local sharing methods (S-LDSC/LDSC, ρ-HESS) plus pleiotropy mapping (MTAG, CPASSOC), it identified pleiotropic loci contributing to significant genetic correlation across trait pairs. This helps clarify the shared genetic architecture underlying gut–joint coupling and supports downstream identification of effector tissues and mechanisms.

Wang L, Li F, Wang J et al. · Journal of translational medicine · (2026) · View on PubMed ↗ · Free PDF ↗

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DNA replication stress & genome stability

Single-molecule tracking of RNA-DNA hybrid removal enzymes important for lagging-strand replication.

This biophysical study used single-molecule tracking to examine RNA-DNA hybrid (RDH) removal enzymes that resolve RDHs formed during lagging-strand replication, including RDHs arising from primase activity, polymerase ribonucleotide misincorporation, and R-loop formation. The key finding is that RDH removal enzymes can be directly visualized at the single-molecule level, enabling mechanistic insight into how RDH persistence is prevented to protect genome stability during replication. Scientifically, it advances understanding of the enzymatic dynamics that suppress mutation-prone RDHs and thereby reduce replication-fork impairment and DNA double-strand break risk.

Foust DJ, Lowder FC, Chung J et al. · Biophysical journal · (2026) · View on PubMed ↗

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Reproductive biology & infertility/fertility disorders

Metabolic Reprogramming in Male Infertility: Mechanistic Integration and Translational Perspectives From Mouse Models.

This article reviewed how metabolic reprogramming is orchestrated during spermatogenesis in mouse models of male infertility, focusing on stage-specific energy pathway switching across spermatogonial proliferation, meiosis, and sperm maturation. The key finding is that successful spermatogenesis depends on coordinated, sequential, context-dependent utilization of multiple bioenergetic pathways rather than reliance on a single energy source, and that infertility arises when this program is disrupted or dysregulated. Clinically, the mechanistic integration of mouse metabolic pathways aims to identify translational metabolic targets and biomarkers to improve diagnosis and treatment of male infertility.

Rong J, Wang L, Yan H et al. · Andrology · (2026) · View on PubMed ↗

Single-cell RNA sequencing reveals immune-peritubular myoid cell crosstalk driving testicular interstitial fibrosis in idiopathic non-obstructive azoospermia.

This study used single-cell RNA sequencing (scRNA-seq) on testicular tissues from patients with idiopathic non-obstructive azoospermia (iNOA) and healthy controls to define immune–peritubular myoid cell crosstalk, with histological validation using H&E and Masson’s trichrome staining. The key finding was that specific immune and peritubular myoid cell interactions identified by scRNA-seq are linked to testicular interstitial fibrosis in iNOA. Scientifically, it provides cell-level mechanistic targets for diagnosing and treating iNOA-associated fibrotic remodeling.

Tan X, Zhang J, Yang Q et al. · Cell & bioscience · (2026) · View on PubMed ↗ · Free PDF ↗

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Infectious disease & antimicrobial pharmacology

Exposure to azithromycin and the effect of co-administration of rifampicin in patients with non-tuberculous mycobacterial disease.

This retrospective pharmacokinetic study measured azithromycin exposure in patients with non-tuberculous mycobacterial (NTM) disease and quantified how co-administration of rifampicin alters drug exposure. The key finding was that rifampicin co-use decreases azithromycin exposure metrics (AUC0-6h, Cmax, and Cmin) compared with patients not receiving rifampicin, using plasma therapeutic drug monitoring data from Radboudumc. The clinical significance is that rifampicin–azithromycin interactions may require dose adjustment or monitoring to maintain effective azithromycin exposure in NTM treatment regimens.

Rodgers MP, Stemkens R, Dahl VN et al. · The Journal of antimicrobial chemotherapy · (2026) · View on PubMed ↗ · Free PDF ↗

Hepatitis B Virus Reactivation Risk With IL-17, IL-23/IL-12, or JAK Inhibitors: A Systematic Review and Meta-Analysis.

This systematic review and meta-analysis quantified hepatitis B virus reactivation (HBVr) risk in patients with chronic or occult HBV infection treated with IL-17, IL-23/IL-12 (anti-IL-23/12), or JAK inhibitors without antiviral prophylaxis, and examined whether risk differed by anti-HBs status among anti-HBc–positive individuals. Across 29 studies (912 patients), pooled incidence estimates showed that these immunomodulatory therapies carry measurable HBVr risk in the absence of prophylaxis, with risk potentially varying by serologic status. The findings support HBV screening and prophylaxis considerations when using IL-17/IL-23/12 or JAK inhibitors in HBV-infected patients.

Alhalabi M, Alshiekh HA · Liver international : official journal of the International Association for the Study of the Liver · (2026) · View on PubMed ↗

Impact of Respiratory Viral Codetections on RSV Disease Burden in Young Children in Primary Care.

This retrospective study assessed how respiratory viral codetections affect RSV disease burden in children under 5 years in primary care, using multiplex real-time PCR testing for RSV and other viruses. Codetection patterns were associated with differences in RSV-related clinical burden, and the impact varied depending on which specific viruses were codetected. The results highlight that interpreting RSV severity may require accounting for coinfecting viruses when planning clinical management and public health interventions.

Duijst L, Sankatsing V, Rizzo C et al. · Influenza and other respiratory viruses · (2026) · View on PubMed ↗ · Free PDF ↗

First Report of Human Infection Caused by Aspergillus steynii and Analysis of Its Whole-Genome Characteristics.

This case report and genomic characterization study investigated the first documented human infection caused by Aspergillus steynii in a 47-year-old woman immunosuppressed after bone marrow transplantation. The pathogen was identified using culture, microscopy, mass spectrometry, multigene molecular identification, and whole-genome sequencing, establishing A. steynii as the causative agent. The findings are clinically significant because they expand the known human pathogenic spectrum of Aspergillus steynii and provide genomic resources that may support future diagnosis and antifungal decision-making.

Wang R, Chen J, Wu N et al. · Transboundary and emerging diseases · (2026) · View on PubMed ↗ · Free PDF ↗

TYG-BMI demonstrates modestly higher predictive value compared to TYG and TYG/HDL for cardiovascular disease incidence in individuals over 45: a longitudinal cohort study.

This longitudinal cohort study compared cardiovascular disease (CVD) predictive performance of triglyceride-glucose (TyG) and derived indices, including TyG-BMI, in adults aged over 45 years. Using secondary analysis of the China Health and Retirement Longitudinal Study (CHARLS) with 5,382 participants and applying Kaplan–Meier and ROC analyses, the authors found that TyG-BMI had modestly higher predictive value for CVD incidence than TyG and TyG/HDL across subgroups. The result suggests TyG-BMI may improve risk stratification for CVD in older adults by better capturing insulin resistance–related metabolic risk.

Chen X, Guo L, Yu Z · Diabetology & metabolic syndrome · (2026) · View on PubMed ↗ · Free PDF ↗

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Mental health, behavior & digital health/measurement

Nurses’ and Physicians’ Experiences With Digital Remote Patient Monitoring-Transforming the Boundaries of Breast Cancer Care.

This qualitative exploratory study examined nurses’ and physicians’ experiences with digital remote patient monitoring for breast cancer care in the Norwegian specialist health service, using semi-structured interviews with nine clinicians before and after implementation and reflexive thematic analysis. It found themes including how remote monitoring supports patient empowerment while also creating risks of reassurance/misinterpretation and guidance challenges, alongside workflow changes with efficiency gains and hidden burdens. These insights are clinically significant for designing and implementing remote monitoring systems that are safe, usable, and supportive for oncology teams.

Spillum MG, Sahlberg GKK, Skjerven HK et al. · Journal of clinical nursing · (2026) · View on PubMed ↗ · Free PDF ↗

Effects of Perioperative Music Interventions on Emotional Outcomes in Children and Adolescents: A Systematic Review and Meta-Analysis Integrating Developmental Psychology and Music Education Perspectives.

This systematic review and meta-analysis studied perioperative music interventions in children and adolescents (≤18 years) undergoing surgery, synthesizing randomized controlled trials comparing music versus no-music controls and assessing outcomes such as preoperative anxiety, postoperative fear, emergence delirium, and related physiological measures. It found that perioperative music can improve emotional outcomes and may influence physiological parameters, with effect sizes and potential effect modifiers evaluated across age and music selection subgroups. These results support perioperative music as a low-risk nonpharmacologic strategy to reduce pediatric perioperative distress.

Wen Y, Han J, Gao J et al. · Paediatric anaesthesia · (2026) · View on PubMed ↗ · Free PDF ↗

Comparison of Clinical Efficiency and Safety Between Intra-Articular Injection of Platelet-Rich Plasma and Hyaluronic Acid for Hip Osteoarthritis: A Systematic Review and Meta-Analysis.

This systematic review and meta-analysis compared intra-articular platelet-rich plasma (PRP) versus hyaluronic acid for hip osteoarthritis, pooling outcomes including VAS pain, Harris Hip Score (HHS), and WOMAC scores from randomized and other eligible studies. It concluded that PRP and hyaluronic acid differ in clinical efficacy and safety profiles, with effect sizes synthesized using standardized mean differences and random-effects models. These findings are clinically relevant for selecting an intra-articular injection strategy for hip osteoarthritis based on pain and function outcomes.

Zhang D, Ma SH, Wang HL et al. · Pain research & management · (2026) · View on PubMed ↗ · Free PDF ↗

[Relationship between family trauma, school bullying and suicidal behavior in adolescents: Regulatory effect of DRD2 gene polymorphism].

This study investigated whether family trauma and school bullying are associated with suicidal behavior in adolescents with depressive disorders and tested whether DRD2 gene polymorphism moderates these relationships. The key finding was that adolescent suicidal behavior related to trauma and bullying differed by DRD2 genotype, indicating a regulatory (gene–environment interaction) effect. The significance is that DRD2 polymorphism may help identify adolescents at higher risk and inform more personalized prevention strategies.

Bai H, Chen Y, Wang K et al. · Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · (2026) · View on PubMed ↗

[Health education preferences in patients with type 2 diabetes mellitus based on Big Five personality traits].

This cross-sectional study assessed how Big Five personality traits relate to health education preferences in patients with type 2 diabetes mellitus (T2DM) in Shandong Province, China. The key finding was that health education preference patterns varied according to Big Five personality trait profiles and demographic factors, supporting heterogeneity in how patients want diabetes education delivered. The clinical significance is that personality-informed tailoring of health education could improve engagement and effectiveness of T2DM self-management interventions.

Yuan S, Min H, Chen P et al. · Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · (2026) · View on PubMed ↗

Clinical Phenomenology of Bipolar Disorder With Substance Use Disorders: A Systematic Review.

This systematic review synthesized 48 clinical studies describing how specific substance use disorders (SUDs)—including alcohol, cannabis, tobacco, stimulants, and opioids—relate to bipolar disorder (BD) clinical phenomenology, symptom severity, and illness course. The key finding was that comorbid SUDs can worsen BD presentation (e.g., more severe mood episodes and poorer recovery), with evidence suggesting substance-specific impacts on BD outcomes. This is important for clinicians because it highlights the need for substance-specific assessment and integrated treatment planning in BD.

Garvie S, Sorkhou M, George TP · Bipolar disorders · (2026) · View on PubMed ↗

Assessing Cognitive Communication Disorders for Return to Work Following Acquired Brain Injury: A Mixed Methods Investigation of Clinical Experiences and Perspectives.

This mixed-methods study investigated how speech-language pathologists (SLPs) assess cognitive communication disorders to support return to work (RTW) after acquired brain injury (ABI), using an online benchmarking survey and expert focus groups. The key finding was that SLPs’ RTW assessment practices and experiences were captured through the sequential survey–focus group design, highlighting real-world clinical perspectives on how cognitive-communication abilities are evaluated for work participation (details truncated in the abstract). Clinically, the work supports improving RTW assessment pathways for ABI by grounding practice recommendations in SLP-reported experiences and expert consensus.

Cameron K, Cornwell P, Watter K et al. · International journal of language & communication disorders · (2026) · View on PubMed ↗

Hydrogen Sulfide Rescues Microglia From HIV Tat-Driven Ferroptosis: Implications for HIV-Associated Neuroinflammation.

This in vitro study tested whether hydrogen sulfide (H2S), delivered as the donor sodium hydrosulfide (NaHS), can rescue microglia from ferroptosis induced by HIV transactivator of transcription (Tat) protein. In BV2 microglial cells, NaHS pretreatment followed by recombinant HIV Tat exposure reduced ferroptotic indices such as cytosolic Fe2+ accumulation and lipid peroxidation/ROS generation (specific results are truncated). These findings suggest an H2S-based protective mechanism against HIV Tat–driven ferroptosis, with implications for treating HIV-associated neuroinflammation and neurocognitive disorders.

Ahsan AU, Martínez-Cuevas FL, Horanieh E et al. · CNS neuroscience & therapeutics · (2026) · View on PubMed ↗ · Free PDF ↗

Recent advances and clinical relevance of microbiome dynamics in health and disease.

This review synthesized recent advances on microbiome dynamics across health and disease, focusing on how microbial communities change over time and influence host biology. The key finding is a consolidated framework describing microbiome dynamics across multiple body niches (gut, skin, oral, respiratory, urogenital) and their roles in immunity, metabolism, and disease processes (detailed conclusions are truncated). The significance is that it supports more dynamic, time-aware microbiome approaches for diagnostics and therapeutics rather than static “snapshot” profiling.

Gavanji S, Suhail M, Bencurova E et al. · Gut microbes · (2026) · View on PubMed ↗ · Free PDF ↗

Spinal cord neuromodulation for autonomic recovery following spinal cord injury: a scoping review.

This scoping review synthesized evidence on spinal cord neuromodulation—specifically spinal cord stimulation (SCS)—for autonomic recovery after spinal cord injury (SCI) across animal models and human studies. The key finding was that SCS has reported effects on autonomic domains including cardiovascular function, bowel function, lower urinary tract (LUT) function, and sexual function, but the evidence base is heterogeneous and requires clearer characterization. Clinically, it supports further targeted research and trial design to optimize SCS parameters and outcomes for autonomic recovery after SCI.

Pandey VK, Law M, Shamatutu C et al. · Journal of neuroengineering and rehabilitation · (2026) · View on PubMed ↗ · Free PDF ↗

Effects of percussive therapy dosages on recovery from acute exercise-induced muscle damage: a systematic review and meta-analysis.

This systematic review and meta-analysis evaluated randomized controlled trials testing dose-related effects of percussive therapy (PT) on recovery after acute exercise-induced muscle damage in human participants. Across neuromuscular performance, muscle soreness, and biochemical markers, the authors assessed how different PT dosages influence post-exercise recovery, using PRISMA-guided searches through November 26, 2025 and risk-of-bias tools (RoB 2, PEDro) with GRADE certainty. The findings are intended to inform evidence-based PT dosing strategies for optimizing recovery after acute muscle injury.

Zhu Y, Yang L, Liu T et al. · Chiropractic & manual therapies · (2026) · View on PubMed ↗ · Free PDF ↗

Two-timepoint multidomain follow-up of post-COVID condition and ME/CFS: overlapping autonomic, small-fiber, and cognitive changes.

This longitudinal two-timepoint study assessed overlapping autonomic dysfunction, small-fiber integrity, and cognitive changes in people with post-COVID condition (PCC) versus myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). In 38 participants (21 PCC, 17 ME/CFS) evaluated about 31 months apart with comprehensive autonomic testing, small-fiber evaluation, and neuropsychological batteries, the authors examined whether trajectories differed between diagnostic groups. The results aim to refine shared versus distinct post-infectious pathophysiology and guide stratified clinical management for PCC and ME/CFS.

Azcue N, Barranco C, Tijero-Merino B et al. · Journal of translational medicine · (2026) · View on PubMed ↗ · Free PDF ↗

Structural barriers and facilitators of accessing rehabilitation among adults aged 50 years and older with low back pain: a scoping review of the literature.

This scoping review mapped structural barriers and facilitators to accessing rehabilitation among adults aged ≥50 years with low back pain (LBP), using Joanna Briggs Institute methodology and qualitative/mixed-method evidence. The key finding is that access experiences are shaped by structural factors (e.g., service and system-level constraints) and may vary by social determinants. The review’s significance is that it provides an evidence map to inform rehabilitation delivery models that reduce inequities for older adults with LBP.

Wong JJ, Ead L, Veitch A et al. · BMC health services research · (2026) · View on PubMed ↗ · Free PDF ↗

How do large language models answer ADHD-related questions? A comparative study of ChatGPT, Gemini, and DeepSeek.

This cross-sectional comparative study assessed how large language models answer ADHD-related questions by testing ChatGPT (GPT-4o), Gemini, and DeepSeek R1 on 22 commonly asked ADHD questions across domains including diagnosis/assessment and treatment/medication. The key finding was that model performance differed across accuracy, reproducibility, quality, usefulness, and reliability, indicating variable reliability of LLM-generated ADHD information. The scientific significance is that it provides evidence-based guidance for safe use of LLMs in ADHD information seeking and highlights the need for evaluation before clinical or caregiver reliance.

Bilgiç B, Turan S, Avcil S et al. · BMC psychiatry · (2026) · View on PubMed ↗ · Free PDF ↗

Consistency of response to rimegepant for the acute treatment of migraine among real-world users - findings from the prospective observational CONFIDENCE study.

This prospective observational CONFIDENCE study evaluated real-world consistency of response to rimegepant for acute migraine treatment across multiple attacks in U.S. adults using the Migraine Buddy app. The key finding was that rimegepant users showed measurable response patterns over repeated migraine attacks, supporting consistency (or identifying variability) in effectiveness in real-world settings. Clinically, the results help patients and clinicians set expectations for rimegepant’s acute benefit across successive attacks outside randomized trial conditions.

Lipton RB, Abraham L, Urani A et al. · The journal of headache and pain · (2026) · View on PubMed ↗ · Free PDF ↗

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Generated automatically on June 15, 2026 from PubMed’s trending articles. Summaries are AI-generated; always consult the original publication for clinical or research decisions.