PubMed Trending Research Digest — August 04, 2026

Automated digest · 94 articles · 15 research areas · August 04, 2026

Overview

Across this week’s PubMed highlights, a strong through-line is the move from “what works” to “why it works” and “who it works for.” Multiple studies dissect mechanistic biology—ranging from mitochondrial oxidative phosphorylation deficits in inclusion body myositis, to kinase control of ferroptosis under mild oxidative stress, to immune–metabolic pathways that shape disease outcomes (e.g., orthodontic-force–driven systemic effects, and macrophage–fibroblast crosstalk in pulmonary fibrosis). These mechanistic insights are increasingly paired with translational aims: identifying actionable targets (TRPA1 antagonism for nociplastic pain; BCL9 inhibition for IPF; GPR81 lactate signaling for senescent muscle) and proposing biomarkers or risk models to guide patient selection.

On the clinical and translational front, several themes converge around precision and safety. In oncology, the focus spans improved diagnostics (PSMA/multiparametric MRI/AI for prostate cancer; rapid 3D histology for glioma infiltration), better stratification (radiotherapy-fibrosis signatures in lung adenocarcinoma; CSF free light chain and neurofilament light chain in autoimmune encephalitis; MRD-triggered imatinib maintenance in Ph+ ALL), and resistance-aware therapy design (frameworks for ADC resistance and next-generation engineering; tumor metabolic competition mechanisms in gastric cancer; multiple studies refining treatment escalation in prostate cancer subgroups). In parallel, real-world evidence and guidance emphasize early detection and monitoring of adverse effects—such as antipsychotic dyslipidemia management, lithium interaction signals with GLP-1 agents, and the cardiovascular risks of unsupervised high-dose statin use.

Finally, the digest reflects a broader “systems biology” shift: digital health and AI are being evaluated not just for performance but for implementation and patient safety (digital patient safety interventions in primary care; LLM performance mapping in inflammatory arthritis). Meanwhile, metabolic and lifestyle exposures—from ultra-processed foods and adipose vs muscle insulin resistance to ketogenic metabolic therapy feasibility in glioblastoma—are being treated as modifiable levers with measurable downstream outcomes. Together, these studies suggest that the next gains in care will come from integrating mechanistic targets, biomarker-guided stratification, and safer deployment of emerging technologies.

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AI/LLMs for Clinical Decision Support

ChatGPT and Other Large Language Models in Inflammatory Arthritis: A Systematic Review Across Clinical Tasks.

This systematic review evaluated the performance of large language models (LLMs) across clinical tasks in inflammatory arthritis, drawing on studies published between January 2022 and April 2026 and covering conditions including rheumatoid arthritis, ankylosing spondylitis/axial spondyloarthritis, psoriatic arthritis, and gout. Across 18 included studies, the review synthesized evidence on how LLMs performed for different rheumatology-related tasks, with coverage spanning multiple inflammatory arthritis phenotypes (e.g., rheumatoid arthritis n=3; axial spondyloarthritis n=7; psoriatic arthritis n=2; gout n=1). The work is significant because it maps current evidence gaps and performance variability of LLMs in inflammatory arthritis, informing safer and more targeted deployment of AI tools in rheumatology workflows.

Adiniaev Y, Omar M, Timor TM et al. · The Journal of rheumatology · (2026) · View on PubMed ↗

Multilevel impairment of mitochondrial respiration in inclusion body myositis.

This study profiled mitochondrial respiration in muscle tissue from patients with inclusion body myositis (IBM) using a comprehensive, multi-level approach spanning RNA-level analyses to high-resolution respirometry on permeabilized muscle fibers. The key finding was that IBM muscle shows multilevel impairment of mitochondrial oxidative phosphorylation/respiratory function, linked to mitochondrial fitness deficits and associated abnormalities including mtDNA abnormalities and altered mitophagy. Clinically and scientifically, these results strengthen the mechanistic connection between mitochondrial dysfunction and IBM pathophysiology and support mitochondrial pathways as potential therapeutic targets.

Shammas I, Iaali H, Watzlawik JO et al. · Brain : a journal of neurology · (2026) · View on PubMed ↗

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Mitochondrial Dysfunction & Oxidative Metabolism

Two stress-responsive kinases suppress ferroptosis by activating antioxidant programs under mild oxidative stress.

This study investigated how the stress-responsive kinases SMG1 and DNA-dependent protein kinase (DNA-PK) regulate ferroptosis under mild oxidative stress. It found that SMG1 and DNA-PK are functionally redundant regulators of redox homeostasis and ferroptosis resistance, with genetic or pharmacological inhibition promoting conditions that disrupt antioxidant programs and increase ferroptosis susceptibility. These results are significant because they identify upstream kinase control points that could be targeted to enhance ferroptosis-based anticancer strategies under physiologically relevant stress.

Fujikawa Y, Imai H, Onuki T et al. · Signal transduction and targeted therapy · (2026) · View on PubMed ↗ · Free PDF ↗

RAB18-dependent recruitment of OPTN initiates selective lipophagy in osteoblasts.

This study examined how the small GTPase RAB18 regulates selective lipophagy in osteoblasts by recruiting the autophagy receptor OPTN (optineurin). RAB18 activation and localization to lipid droplets enabled direct OPTN recruitment, promoting OPTN–LC3 bridging and lysosomal degradation of lipid droplets, while loss of RAB18 or OPTN impaired lipophagic flux and osteogenic differentiation. Scientifically, it defines a RAB18→OPTN axis as an upstream control mechanism for lipophagy in bone cells, suggesting potential targets for disorders involving lipid handling and impaired osteogenesis.

Ji C, Xu L, Zheng F et al. · Autophagy · (2026) · View on PubMed ↗

Proteomic comparison of hippocampal neurofibrillary tangles in PART, intermediate Alzheimer’s disease and advanced Alzheimer’s disease.

The study used an unbiased proteomic workflow to compare hippocampal neurofibrillary tangle (NFT) proteomes isolated from Tau AT8-positive, pSer202/pThr205 neurons in PART (primary age-related tauopathy) versus intermediate and advanced Alzheimer’s disease cases. Concomitant β-amyloid (Aβ) pathology altered the NFT proteome relative to PART, indicating that Aβ modifies the molecular composition of tau tangles across disease stages. These findings support stage- and co-pathology–specific tau biology and suggest proteomic NFT signatures could refine mechanistic models and potential biomarkers for Alzheimer’s progression.

Thierry M, Leitner D, Balcomb K et al. · Acta neuropathologica · (2026) · View on PubMed ↗ · Free PDF ↗

Targeting TRPA1 antagonists for nociplastic pain: systematic review and meta-analysis of preclinical evidence.

This systematic review and meta-analysis synthesized preclinical evidence on transient receptor potential ankyrin 1 (TRPA1) antagonists for nociplastic pain, focusing on animal and other preclinical nociplastic pain models. The key finding was that TRPA1 antagonists consistently reduced nociception/hypersensitivity across multiple nociplastic pain paradigms in preclinical studies. This is significant because it consolidates the translational rationale for TRPA1 blockade while highlighting the need for better biomarkers and clinical validation in nociplastic pain patients.

Antoniazzi C, Brito HA, Rodrigues P et al. · European journal of pharmacology · (2026) · View on PubMed ↗

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Nociplastic Pain & TRP Channels

Asiaticoside attenuates endothelial cells senescence in diabetic retinopathy via CCND1-mediated mitophagy through the PI3K/AKT/mTOR pathway.

This experimental study investigated whether asiaticoside (AC) protects endothelial cells in diabetic retinopathy by modulating CCND1-mediated mitophagy through the PI3K/AKT/mTOR signaling pathway. The key finding was that asiaticoside attenuated endothelial cell senescence and promoted CCND1-mediated mitophagy via PI3K/AKT/mTOR pathway regulation. Scientifically and potentially clinically, the results identify a mechanistic axis (PI3K/AKT/mTOR → CCND1 → mitophagy) that could be leveraged to develop targeted therapies to preserve vascular function in diabetic retinopathy.

Chen Z, Luo Y, Lou X et al. · Journal of ethnopharmacology · (2026) · View on PubMed ↗

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Secretory Trafficking & ER Exit Sites

Cooperative definition of ER exit sites by Tango1, Sec16 and Sec12.

This study used Drosophila to dissect how the ER exit site (ERES) proteins Sec16, Sec12, and the animal-specific Tango1 cooperatively define ERES morphogenesis. Sec16 and Tango1 were interdependent for proper ERES assembly, and co-overexpression produced exaggerated ERES structures, with the work also identifying CG9175 as a Drosophila factor involved in this pathway. These findings clarify the cooperative molecular logic of ERES formation and refine conserved versus animal-specific determinants of secretory trafficking.

Feng Z, Martín M, Rojas M et al. · Journal of cell science · (2026) · View on PubMed ↗ · Free PDF ↗

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Cardiovascular Risk, Dyslipidemia & Drug Safety

Clinical Practice Guideline on the Pharmacological Management of Antipsychotic-Related Dyslipidemia.

This article presents a clinical practice guideline for pharmacological management of antipsychotic-related dyslipidemia in people with severe mental illness who are at elevated cardiovascular risk. It emphasizes that lipid increases can occur soon after starting antipsychotics and are often undertreated, recommending more systematic use of lipid-lowering strategies to reduce long-term atherosclerotic risk. The guideline is intended to improve prevention of cardiovascular disease in patients receiving antipsychotic medications.

Carolan A, Hynes-Ryan C, Bourke R et al. · Schizophrenia bulletin · (2026) · View on PubMed ↗

Lithium and GLP-1-based therapies in bipolar disorder: an emerging pharmacovigilance signal and monitoring considerations.

This pharmacovigilance-focused review analyzed emerging safety signals and monitoring considerations for lithium when used alongside GLP-1 receptor agonists or dual GIP/GLP-1 agonists in bipolar disorder. It summarizes six bibliographically distinct reports since 2025 describing lithium elevation or toxicity after GLP-1-based therapy changes and notes that the European Medicines Agency’s Pharmacovigilance Risk Assessment Committee opened a signal in June 2026 for a drug interaction increasing lithium levels. The clinical significance is improved risk awareness and monitoring guidance to prevent lithium toxicity during GLP-1-based co-therapy.

Cotrik E, da Silva AG, Soares JC · International clinical psychopharmacology · (2026) · View on PubMed ↗

Atorvastatin-Associated Severe Bradyarrhythmia Following Multiorgan Dysfunction: A Case Report.

This case report described a 66-year-old man who developed severe bradyarrhythmia after self-escalating atorvastatin from 20 mg/day to 80 mg/day, in the setting of multiorgan dysfunction. The key finding was that the patient presented with syncope and electrocardiographic sinus arrest with ventricular escape rhythm alongside acute hepatic and renal dysfunction and electrolyte/coagulation abnormalities. Clinically, the report underscores the risk of serious cardiac adverse events from high-dose unsupervised statin use, especially when systemic organ dysfunction and metabolic derangements occur.

Kou XQ, Wang YZ, Gan YR et al. · Clinical case reports · (2026) · View on PubMed ↗ · Free PDF ↗

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Cancer Diagnostics & Imaging/AI Segmentation

Ultrarapid deep 3D histology enables intraoperative mapping of glioma infiltration.

This study evaluated ULTRA (ultrarapid cleared stimulated Raman with AI), a label-free, stain-free, fixation-free, section-free 3D histology platform using stimulated Raman scattering (SRS) microscopy plus one-step tissue clearing and unsupervised learning, for intraoperative mapping of glioma infiltration in FFPE specimens. It found that ULTRA enables ultrarapid, high-resolution deep 3D histological analysis suitable for intraoperative consultation. The clinical significance is improved real-time delineation of glioma infiltration to support surgical decision-making and potentially better prognostication.

Liu Z, Li Y, Chen L et al. · Cell · (2026) · View on PubMed ↗

Classic Hodgkin Lymphoma: A Review.

This JAMA review studied classic Hodgkin lymphoma (cHL), summarizing epidemiology, clinical presentation patterns (including bimodal age distribution and typical lymph node involvement), and current diagnostic and management concepts. It found that cHL accounts for the majority of Hodgkin lymphoma cases and has characteristic demographic and clinical features that guide recognition and workup. The significance is that it provides an up-to-date clinical framework for diagnosis and treatment planning in a common hematologic malignancy.

Patel KK, Moskowitz AJ · JAMA · (2026) · View on PubMed ↗

Present status of prostate cancer diagnosis, limitations, challenges, and future endeavors.

This review summarizes current prostate cancer (PCa) diagnostic approaches, focusing on limitations of conventional testing and the roles of PSMA-directed imaging, mpMRI-guided biopsy, liquid biopsies, and AI/ML for lesion detection and segmentation. It highlights that PSMA-directed imaging can improve lesion localization for biopsy, while emerging molecular/imaging liquid biopsy methods and AI/ML models aim to increase speed and accuracy of detection and characterization. The synthesis supports future diagnostic strategies that may improve precision and consistency in PCa detection and risk assessment.

Hooda K, Chatterjee M, Sharma AP et al. · Annals of medicine · (2026) · View on PubMed ↗ · Free PDF ↗

Radical Prostatectomy Without Prior Biopsy? Final Histopathology of Radical Prostatectomies in 103 Consecutive Biopsy-naïve Patients Who Underwent Radical Prostatectomy.

This retrospective single-center cohort study evaluated final histopathology and potential active surveillance (AS) eligibility after biopsy-naïve radical prostatectomy (bnRP) in 103 consecutive patients with imaging-suspicious, pT2–pT3 disease. The key finding was the characterization of final pathological outcomes in patients who underwent radical prostatectomy without prior biopsy, enabling estimation of which patients might have been AS candidates and assessment of short-term biochemical recurrence (BCR)-free survival. Clinically, the study informs decision-making and risk stratification for patients refusing biopsy despite suspicious imaging.

Semmler M, Marcon J, Berg EK et al. · European urology focus · (2026) · View on PubMed ↗ · Free PDF ↗

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Cancer Drug Response, Resistance & Therapeutic Strategies

The next generation of antibody-drug conjugates.

This review studied the current state of antibody-drug conjugates (ADCs)—monoclonal antibodies linked to cytotoxic payloads—and how mechanisms of action and resistance in patients inform ADC chemistry and combination strategies. It finds that progress is increasingly driven by integrating multiple chemistry advances into single ADC designs, because single modifications or combinations are unlikely to yield clinically meaningful benefit alone and the pace of innovation is outstripping clinical trial capacity. The work is significant because it proposes a framework for next-generation ADC development that could accelerate more effective, rationally engineered therapies for cancer patients.

Mosele F, Peltier A, Ozaki Y et al. · Nature medicine · (2026) · View on PubMed ↗

Addition of High-Dose Vitamin D3 to Standard Treatment in Patients With Metastatic Colorectal Cancer: The SOLARIS Randomized Clinical Trial (Alliance A021703).

This double-blind phase 3 randomized clinical trial (SOLARIS; Alliance A021703) studied whether adding high-dose vitamin D3 to standard chemotherapy (mFOLFOX6-based) improves outcomes in 455 previously untreated patients with metastatic colorectal cancer (mCRC). The key finding reported in the abstract was that high-dose vitamin D3 improved progression-free survival (PFS) versus standard-dose vitamin D3. Clinically, this supports a potential adjunct strategy using vitamin D3 dosing to enhance chemotherapy benefit in mCRC.

Ng K, Ou FS, Zemla T et al. · JAMA · (2026) · View on PubMed ↗

METTL7A Downregulation Drives SLC1A5-Mediated Glutamine Competition to Promote Tumor Proliferation and Suppress CD8+ T Cell Immunity in Gastric Cancer.

This work studied gastric cancer (GC) mechanisms using the METTL7A–SLC1A5 axis to determine how glutamine metabolism affects tumor growth and CD8+ T-cell immunity. The key finding was that METTL7A downregulation promotes SLC1A5-mediated glutamine competition: GC cells accumulate glutamine to drive proliferation while depleting glutamine availability to CD8+ T cells, suppressing antitumor immunity. Clinically, it identifies METTL7A and SLC1A5 as actionable metabolic regulators that could be targeted to improve immunotherapy responsiveness in GC.

Sun M, Dang S, Zhou D et al. · Advanced science (Weinheim, Baden-Wurttemberg, Germany) · (2026) · View on PubMed ↗ · Free PDF ↗

Cancer drug response and resistance: molecular mechanisms and combating strategies.

This review analyzed molecular and cellular mechanisms of cancer drug response and resistance across multiple tumor types, distinguishing intrinsic resistance from acquired resistance arising during or after therapy. It synthesizes determinants of resistance across 22 cancer types and emphasizes the dynamic, multifactorial nature of how tumors evade chemotherapy, targeted therapy, and immunotherapy. Clinically, the work supports developing combination and adaptive treatment strategies informed by resistance biology to improve durable responses and long-term survival.

Cheng X, Xu M, Wei J et al. · Signal transduction and targeted therapy · (2026) · View on PubMed ↗ · Free PDF ↗

Efficacy of imatinib maintenance after stem cell transplantation for Ph+/BCR::ABL1 positive ALL: long-term outcome of a randomized trial and impact of peritransplant minimal residual disease.

This randomized trial evaluated long-term outcomes of imatinib maintenance after allogeneic stem cell transplantation (HSCT) in adults with Philadelphia chromosome-positive (Ph+)/BCR::ABL1-positive acute lymphoblastic leukemia (ALL), comparing prophylactic versus minimal residual disease (MRD)-triggered imatinib and analyzing peritransplant MRD impact. The final analysis showed no significant differences between prophylactic and MRD-triggered imatinib arms in cumulative incidence of relapse, non-relapse mortality, leukemia-free survival, or overall survival at 10 years. Clinically, the results support the feasibility of MRD-triggered imatinib strategies after HSCT and help refine maintenance approaches for Ph+ ALL while incorporating MRD dynamics.

Pfeifer H, Bethge W, Schönland S et al. · Leukemia & lymphoma · (2026) · View on PubMed ↗ · Free PDF ↗

FGF/FGFR Alteration Type as a Candidate Enrichment Biomarker for Gunagratinib in Recurrent or Metastatic Head and Neck Cancer: An Exploratory Analysis of Two Early-Phase Trials.

This exploratory analysis pooled two early-phase prospective trials to test whether the FGF/FGFR alteration type predicts response to gunagratinib, a pan-FGFR1-4 inhibitor, in recurrent or metastatic head and neck cancer. Across patients with FGF/FGFR-altered tumors treated in phase I (ICP-CL-00301) and phase IIa (ICP-CL-00304 at 20 mg once daily), objective response outcomes were analyzed by specific alteration categories. The study is clinically relevant because it aims to refine biomarker stratification beyond “FGF/FGFR altered” status to better select patients likely to benefit from FGFR inhibition.

Xue L, Zhu G, Wang P et al. · Targeted oncology · (2026) · View on PubMed ↗

Treatment of Hot Flashes in Men With Prostate Cancer Undergoing Androgen Deprivation Therapy.

This systematic review evaluated pharmacological and non-pharmacological interventions for treating hot flashes in men with prostate cancer undergoing androgen deprivation therapy (ADT), including castration therapy settings in metastatic and localized/locally advanced disease. The review found that evidence for effective relief of vasomotor symptoms in this population remains limited across available interventions. Clinically, the findings highlight an unmet need for higher-quality trials to guide management of ADT-associated hot flashes in prostate cancer patients.

Schaldemose EL, Poulsen MH, Nørby B et al. · The Prostate · (2026) · View on PubMed ↗

Clinical Impact of Gleason Pattern 5 on Doublet Versus Triplet Therapy in Metastatic Hormone-Sensitive Prostate Cancer.

This real-world study assessed whether triplet therapy with darolutamide plus docetaxel (vs doublet therapy with apalutamide or enzalutamide) is associated with outcomes in metastatic hormone-sensitive prostate cancer stratified by Gleason pattern 5 (GP5) status. The key finding was that the presence of Gleason pattern 5 identified a more aggressive subgroup in which triplet therapy showed differential clinical impact compared with doublet approaches. Scientifically and clinically, GP5 may help refine treatment selection among mHSPC patients considering escalation from androgen receptor pathway inhibitor doublets to darolutamide–docetaxel triplet therapy.

Fujimoto S, Morita T, Yamamoto Y et al. · The Prostate · (2026) · View on PubMed ↗ · Free PDF ↗

HAIC combined with lenvatinib and tislelizumab for HCC with concurrent PVTT and pulmonary metastasis: a multicenter propensity score matching analysis.

This multicenter retrospective propensity score matching study compared hepatic arterial infusion chemotherapy (HAIC) combined with lenvatinib and tislelizumab (HLP) versus other real-world approaches in treatment-naïve hepatocellular carcinoma (HCC) patients with concurrent portal vein tumor thrombus (PVTT) and pulmonary metastasis (PM). The key finding was that the HAIC–lenvatinib–tislelizumab regimen showed improved efficacy and acceptable safety in this very high-risk subgroup after propensity score matching. The clinical significance is that HLP may offer a more effective treatment option for HCC patients with both PVTT and PM, where outcomes are typically poor.

Chen S, Wu Z, Xiao Y et al. · Therapeutic advances in medical oncology · (2026) · View on PubMed ↗ · Free PDF ↗

The requirement of MALT1 activity for the growth of adult T cell leukemia/lymphoma.

This study examined the requirement of MALT1 protease activity for the growth of adult T cell leukemia/lymphoma (ATL) using a selective MALT1 protease inhibitor (CRD-1441551) across ATL cell lines and patient-derived xenograft models. The key finding was that MALT1 activity was necessary for ATL growth, with CRD-1441551 showing variable antitumor effects across models and identifying sensitivity patterns among cell lines and xenografts. Clinically, it supports MALT1 as a therapeutic vulnerability in ATL and provides preclinical rationale for targeting the MALT1 protease in patients.

Kamiunten A, Morishita D, Kameda T et al. · iScience · (2026) · View on PubMed ↗ · Free PDF ↗

Real-World Retrospective Analysis of Daratumumab for Relapsed or Refractory Multiple Myeloma in Regional Australia.

This real-world retrospective analysis evaluated daratumumab-based therapy for relapsed or refractory multiple myeloma in regional Australia using data from two regional tertiary centers between 2018 and 2023. The key finding was that among 52 patients (median age 74; 59% high-risk cytogenetics), the overall response rate was 35% with median progression-free survival (PFS) of 13 months, with most patients receiving daratumumab plus bortezomib and dexamethasone. This is significant for benchmarking effectiveness and informing expectations for daratumumab regimens in non-metropolitan clinical settings.

Reardon B, Kerridge I, Armytage T · Asia-Pacific journal of clinical oncology · (2026) · View on PubMed ↗ · Free PDF ↗

Hepatectomy After Progressive Disease Following Chemotherapy for Colorectal Liver Metastases: A Japanese Nationwide Cohort Study.

This Japanese nationwide cohort study evaluated postoperative outcomes in patients with colorectal liver metastases who developed progressive disease after systemic chemotherapy, comparing those who underwent hepatectomy versus no resection. The key finding is that hepatectomy after progression was associated with survival outcomes and prognostic factors that differed from patients with controlled disease, indicating that surgery may still be beneficial in selected patients. This is clinically significant because it informs decision-making on whether to proceed with liver resection despite chemotherapy progression.

Kobayashi K, Kishi Y, Yonamine N et al. · Annals of surgical oncology · (2026) · View on PubMed ↗ · Free PDF ↗

Targeting RPRD1B overcomes chemoresistance in gastric cancer by suppressing the TOPBP1-mediated DNA damage repair pathway.

This study examined whether targeting RPRD1B (CREPT) can overcome chemotherapy resistance in gastric cancer by suppressing the TOPBP1-mediated DNA damage repair pathway. The key finding is that RPRD1B inhibition reduces TOPBP1-driven DNA damage repair, thereby sensitizing gastric cancer cells to chemotherapy and countering innate/acquired resistance. These results are significant because they nominate the RPRD1B–TOPBP1 axis as a potential therapeutic strategy to improve responses to 5-fluorouracil (5-FU)-based regimens.

Sheng J, Li J, Cao C et al. · Cellular oncology (Dordrecht, Netherlands) · (2026) · View on PubMed ↗ · Free PDF ↗

The anti-tumour activity of TNF in melanoma is determined by cFLIP.

This study investigated how tumor necrosis factor (TNF) influences melanoma growth and why TNF can show paradoxical anti- versus pro-tumor effects, focusing on the role of cFLIP in melanoma cells. The key finding is that cFLIP expression determines melanoma susceptibility to TNF and controls tumor growth in a syngeneic, immune-competent B16F10 mouse model. This is clinically significant because it suggests cFLIP as a biomarker and potential therapeutic target for modulating TNF-based anti-tumor strategies in melanoma.

Stachelscheid J, Kaul C, Gerstenberg K et al. · Cell death & disease · (2026) · View on PubMed ↗ · Free PDF ↗

Oncogene SETDB1’s dual role: driving tumor progression and immune escape.

Using endometrial cancer (EC) models, the study examined the dual role of the histone H3K9 methyltransferase SETDB1 by comparing SETDB1 knockout (SETDB1-/-) versus control tumor-bearing mice and profiling SETDB1-/- EC cells with transcriptomics. SETDB1 loss reduced oncogenic gene expression, increased tumor suppressor gene expression, and prolonged survival in mice, while also derepressing repeat elements and the interferon pathway to mediate immune evasion changes via effects on anti-tumor macrophage infiltration. These results position SETDB1 as both a tumor-promoting epigenetic regulator and an immune-escape driver, suggesting SETDB1-targeting could have combined anti-cancer and immunomodulatory therapeutic value.

Salari K, Hao J, Jilek R et al. · Oncogene · (2026) · View on PubMed ↗ · Free PDF ↗

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Immunotherapy Engineering & Adaptive Immune Mapping

Uncovering ectopic GC-like niches for tumor reactive lymphocyte priming in lung adenocarcinoma using Stereo-XCR-seq.

This study developed Stereo-XCR-seq to recover and sequence T-cell receptor (TCR) and B-cell receptor (BCR) (XCR) sequences from spatial transcriptome cDNA libraries at subcellular resolution in lung adenocarcinoma tissues. It found that the method enables high-fidelity, unbiased in situ XCR sequencing and identifies heterogeneous lymphoid aggregates containing ectopic GC-like niches that support tumor-reactive lymphocyte priming. The scientific significance is that Stereo-XCR-seq provides a spatially resolved way to map adaptive immune clonal evolution in tumors, enabling mechanistic discovery and potential biomarker development for immunotherapy response.

Zhan X, Huang M, Zhang Y et al. · Nature communications · (2026) · View on PubMed ↗

Multiomics Dissection Reveals Natural Killer Cell-CD8+ T-cell Cooperation in Shaping an Immunostimulatory Tumor Microenvironment.

This study used integrative multiomics—spatial transcriptomics, single-cell RNA sequencing, and high-dimensional flow cytometry—to define how natural killer (NK) cells and CD8+ cytotoxic T lymphocytes (CTLs) cooperate in shaping the tumor microenvironment in tumors with low T-cell infiltration. The key finding was that vaccination rapidly remodels the tumor microenvironment and that early infiltration of IRF8+KLRG1+ NK cells establishes a chemokine-rich niche that supports CTL/NK synergy. Scientifically, it identifies a specific NK-cell state (IRF8+KLRG1+) as a mechanistic lever for improving immunotherapy responses in poorly infiltrated tumors.

Shimizu K, Sanpei A, Liu Y et al. · Cancer research · (2026) · View on PubMed ↗

Accelerating Translation of NK Cell Therapies to the Clinic: A European Perspective.

This European perspective article discussed the translational pathway for NK cell therapies to the clinic, focusing on lessons from CAR-T approvals in Europe and the distinct advantages of NK and γδ T cell approaches. The key finding was not a primary experimental result (the abstract is truncated), but rather a synthesis of challenges and considerations for clinical translation of NK cell products. Scientifically and clinically, it aims to guide development strategies to improve safety, efficacy, manufacturing, and regulatory readiness for NK-based immunotherapies.

Knapp LR, Fischer KS, Sosat J et al. · Human gene therapy · (2026) · View on PubMed ↗

JMB2403, a potential best-in-class PD-1-dependent IL2Rβγ-activating tri-specific antibody for safe and potent immunotherapy.

The study developed and characterized JMB2403, a PD-1-dependent IL2Rβγ-activating tri-specific antibody, using an alpaca-derived nanobody screen and in vitro STAT5 reporter assays. JMB2403 did not bind IL2Rα (CD25) but activated STAT5 phosphorylation in an engineered Jurkat cell reporter assay at much lower potency than wild-type IL-2, translating into improved safety-related behavior in subsequent experiments (details truncated). This work is significant because it offers a PD-1/IL-2Rβγ tri-specific design intended to reduce dose-limiting toxicity while preserving IL-2 pathway signaling for immunotherapy.

Gu C, Wang D, Wang Y et al. · mAbs · (2026) · View on PubMed ↗ · Free PDF ↗

Sensing the enemy within: Vγ9Vδ2 T cells as metabolic sensors of intracellular parasites.

This review synthesizes evidence that human Vγ9Vδ2 T cells act as metabolic sensors of intracellular parasites by recognizing nonpeptidic phosphoantigens (pAgs) through intracellular pAg accumulation and BTN3A1–BTN2A1 receptor cooperation to activate the γδ T cell receptor. It highlights how this sensing mechanism drives rapid cytotoxicity and interferon-gamma responses against parasites such as Plasmodium falciparum and Toxoplasma gondii. The review’s significance is that it clarifies a core immunobiology pathway that can be exploited for immunotherapies targeting intracellular infections.

Rodriguez F, Saeij JPJ · Trends in parasitology · (2026) · View on PubMed ↗ · Free PDF ↗

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Biomarkers & Prognostic Models

Kappa Free Light Chain for Diagnosis and Neurofilament Light Chain for Prognosis in Autoimmune Encephalitis.

This multicenter prospective cohort study analyzed paired cerebrospinal fluid (CSF) and serum samples from 92 adults with definite autoimmune encephalitis (including anti-NMDAR cases) to assess diagnostic and prognostic biomarkers. It found that CSF kappa free light chain supported diagnosis and CSF neurofilament light chain supported prognosis, addressing limitations of existing biomarkers and incorporating CSF markers into clinical utility. The clinical significance is improved early diagnostic accuracy and severity/prognosis stratification in autoimmune encephalitis using CSF free light chain and neurofilament light chain measurements.

Konen FF, Bucak E, Bachhuber F et al. · Neurology(R) neuroimmunology & neuroinflammation · (2026) · View on PubMed ↗

Serum Glial Fibrillary Acidic Protein Dynamics, Disease Progression, and Therapy Response in Multiple Sclerosis.

This prospective observational study measured serum glial fibrillary acidic protein (GFAP) dynamics in two large MS cohorts (Swiss MS Cohort and EPIC) to test whether GFAP levels and treatment-related changes predict future progression independent of relapse activity (PIRA). It found that serum GFAP trajectories and treatment-associated changes were associated with subsequent progression risk even after accounting for relapse activity, and results were validated across cohorts. The clinical significance is that serum GFAP could serve as a practical biomarker for identifying patients at risk of disability progression independent of relapses, supporting treatment monitoring and stratification.

Einsiedler M, Sandgren S, Schaedelin S et al. · JAMA neurology · (2026) · View on PubMed ↗

A radiotherapy-related fibrosis gene signature-based risk model for predicting prognosis and immunological features in lung adenocarcinoma.

This study developed and validated a prognostic risk model for lung adenocarcinoma (LUAD) based on a radiotherapy-related fibrosis gene signature and assessed associated immunological features. Using transcriptomic datasets from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO), the authors identified radiotherapy-related fibrosis genes and built the model with differential expression screening followed by LASSO regression and multivariable analysis. The resulting signature is significant for predicting prognosis and characterizing tumor immune contexture in LUAD patients facing radiation-induced fibrosis risk.

Qiu Y, Lv C, Ding S · Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · (2026) · View on PubMed ↗

Development and independent validation of a hypoxemia risk prediction model (HAPPY-12K) for sedated gastrointestinal endoscopy: a multicentre prospective cohort study.

This multicentre prospective cohort study developed and independently validated the HAPPY-12K hypoxemia risk prediction model for sedated gastrointestinal endoscopy using pre-operative data from outpatients across seven hospitals in China. The key finding was that HAPPY-12K provides a robust, accurate, pre-operative tool to estimate hypoxemia risk during sedated endoscopy, addressing the lack of an endoscopy-specific model beyond obstructive sleep apnea and difficult airway assessment. Clinically, it could improve patient selection and monitoring strategies to reduce hypoxemia-related complications during GI endoscopy.

Li N, Xu X, Xue M et al. · EClinicalMedicine · (2026) · View on PubMed ↗ · Free PDF ↗

Advancing Alzheimer’s disease research in China: insights, innovations, and future directions from the chinese preclinical Alzheimer’s disease study (CPAS).

This review summarizes the Chinese Preclinical Alzheimer’s Disease Study (CPAS), which enrolls cognitively unimpaired participants, mild cognitive impairment (MCI) patients, and dementia patients to identify early Alzheimer’s pathology using plasma biomarkers and PET imaging, with emphasis on the diagnostic impact of Aβ-PET. It reports that integrating Aβ-PET with plasma biomarkers and longitudinal clinical assessments improves early detection and characterization of Alzheimer’s pathology across the cognitive spectrum. The work highlights CPAS as a platform for validating preclinical diagnostic strategies in China and for guiding future trials targeting early disease.

Wang J, Huang L, Li B et al. · Molecular psychiatry · (2026) · View on PubMed ↗

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Digital Health & Patient Safety Interventions

Digital patient safety interventions in primary care: a systematic review and meta-analysis.

This systematic review and meta-analysis evaluated digital patient safety interventions implemented in primary care, including both single-component and multicomponent strategies. It aimed to determine effectiveness in reducing patient safety events and to identify which intervention components and implementation factors are associated with success. The work is significant for guiding evidence-based deployment of digital tools to prevent adverse events in primary care settings.

Tsang JY, Planner C, Low CN et al. · BMC medicine · (2026) · View on PubMed ↗ · Free PDF ↗

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Metabolic Health, Diet & Endocrine Regulation

Palmitoylation of TK1 exacerbates osteoarthritis by promoting JNK-mediated metabolic reprogramming.

This study investigated the role of thymidine kinase 1 (TK1) palmitoylation in osteoarthritis (OA) by integrating quantitative proteomics with reanalysis of human articular cartilage single-cell RNA-seq data and mechanistic experiments focused on IL-1β signaling. It found that IL-1β enhances S-palmitoylation of TK1 at Cys153, promoting USP9X-dependent deubiquitination and preventing proteasomal degradation, leading to TK1 accumulation that scaffolds JNK signaling, increases PRMT1 and PFKFB3 expression, and drives excessive glycolysis and matrix breakdown. The scientific significance is identification of a TK1 palmitoylation–USP9X–JNK metabolic reprogramming axis as a potential disease-modifying target in OA.

Zhang Z, Zhang C, Ju Y et al. · Proceedings of the National Academy of Sciences of the United States of America · (2026) · View on PubMed ↗

Markers of ultra-processed food and incident arterial hypertension in the UK Biobank.

This exploratory prospective cohort study in 101,560 non-hypertensive UK Biobank participants assessed associations between ultra-processed food (UPF) intake and incident arterial hypertension, including specific markers of ultra-processing (MUPs) derived from product ingredient lists. It found that UPF intake and certain MUP categories/markers were associated with higher risk of developing arterial hypertension over follow-up. The significance is that it moves beyond “UPF” as a single exposure by linking incident hypertension to more specific ultra-processing-related ingredients, supporting more actionable dietary risk reduction.

Krost KM, Eichner G, Fasshauer M et al. · European heart journal · (2026) · View on PubMed ↗

Weight reduction-dependent/-independent effects of survodutide on liver endpoints: Mediation analysis of a phase 2 trial in MASH.

This post hoc mediation analysis studied survodutide effects on liver histology/endpoints in participants with MASH (NCT04771273), using causal mediation models to separate direct treatment effects from indirect effects mediated by weight reduction. It found that improvements in liver endpoints could be decomposed into portions mediated by percentage body-weight change versus direct effects, with covariates including baseline body weight, type 2 diabetes status, and fibrosis stage. The significance is that it clarifies whether survodutide’s hepatic benefits are primarily weight-loss dependent or also reflect weight-independent mechanisms, informing clinical expectations and trial design.

Noureddin M, Sanyal AJ, Bedossa P et al. · Hepatology (Baltimore, Md.) · (2026) · View on PubMed ↗

Semaglutide-Induced Sarcopenia via GLP-1R-mTOR-Satellite Cells Axis and Muscle-Glucose Feedback Loop Potentially Leading to Refractory Hyperglycemia in Type 2 Diabetes: A Case-Driven Hypothesis.

This case-driven hypothesis describes a 53-year-old man with type 2 diabetes mellitus (T2DM) who developed progressive glycemic failure and sarcopenic symptoms after treatment escalation from dulaglutide to semaglutide (titrated from 0.25 to 1 mg weekly). The key proposed finding is that semaglutide may induce sarcopenia via a GLP-1R–mTOR–satellite cell axis and a muscle–glucose feedback loop, potentially contributing to refractory hyperglycemia. If supported by further evidence, it would raise mechanistic safety questions about GLP-1 receptor agonists in patients at risk for muscle loss.

Ahmed A, Rodini S, Alrubyea F et al. · Problemy endokrinologii · (2026) · View on PubMed ↗ · Free PDF ↗

Protecting Musculoskeletal Development and Physical Function in Adolescents on GLP-1 Therapy.

This article reviewed and synthesized concerns about musculoskeletal development in adolescents receiving GLP-1 therapy (including semaglutide and liraglutide) during critical growth periods. The key finding was that GLP-1–associated weight loss may attenuate muscle and bone mass accrual, potentially reducing peak musculoskeletal outcomes, even though GLP-1s improve obesity-related cardiometabolic health and can enable physical activity. Clinically, it highlights the need for monitoring and long-term studies of musculoskeletal maturation when prescribing GLP-1 receptor agonists to youth.

Smith WA, Kim A, Khalil TJ et al. · Childhood obesity (Print) · (2026) · View on PubMed ↗

Diabetes Mellitus and Long-Distance Running: A Systematic Review.

This systematic review synthesized evidence on diabetes mellitus in long-distance runners, including prevalence, performance impacts, and methods for blood glucose monitoring and glycemic control. It searched multiple databases through April 2024 to compile current knowledge on how runners with diabetes manage glucose during endurance training and competition. The review is significant for informing athlete care and for identifying gaps where better evidence is needed on monitoring and control strategies in this population.

Braschler L, Thuany M, Züger T et al. · Sports medicine - open · (2026) · View on PubMed ↗ · Free PDF ↗

Adipose tissue insulin resistance, not muscle insulin resistance, is associated with impaired metabolic health in humans.

The study investigated in humans whether adipose tissue insulin resistance versus muscle insulin resistance is associated with impaired metabolic health. Using baseline data from 229 adults in the PERSON study and categorizing participants by indices of muscle and adipose insulin sensitivity (muscle IR from a 7-point oral glucose tolerance test; adipose IR from fasting insulin and non-esterified fatty acids), it found that adipose tissue insulin resistance—not muscle insulin resistance—correlated with worse metabolic health (details truncated). Clinically, this supports targeting adipose insulin resistance as a more relevant therapeutic focus for improving cardiometabolic risk.

Meshkat K, Gijbels A, Afman LA et al. · Diabetes research and clinical practice · (2026) · View on PubMed ↗ · Free PDF ↗

Wedelolactone targets SORBS1 to regulate glycolipid metabolism and suppress inflammation, thereby alleviating diet-induced MASH via multiple pathways.

The study tested whether the natural product wedelolactone (WED) can ameliorate diet-induced metabolic dysfunction-associated steatohepatitis (MASH) and sought its molecular target(s). It used an in vitro MASH model (details truncated) to evaluate WED’s hepatoprotective effects and to identify SORBS1 as a key target regulating glycolipid metabolism and suppressing inflammation through multiple pathways. These findings are significant because they propose SORBS1-centered mechanisms for WED’s potential as a pharmacologic therapy for diet-induced MASH.

Zhang W, Bai Y, Xu D et al. · Phytomedicine : international journal of phytotherapy and phytopharmacology · (2026) · View on PubMed ↗

Peitu Qingxin formula ameliorates atopic dermatitis by targeting the multi-omics-informed miR-30a/GAPR-1 axis in sphingolipid metabolism.

The study evaluated the traditional formula Peitu Qingxin (PTQX) in atopic dermatitis and aimed to define a mechanism in sphingolipid metabolism via a miR-30a/GAPR-1 axis. Using Mendelian randomization, clinical proteomics, and dual-luciferase reporter assays, it identified miR-30a as a direct upstream regulator of GAPR-1 and validated the axis in AD-like 3D skin equivalents, with PTQX shown to modulate the pathway (dose details truncated). This is clinically relevant because it links PTQX efficacy to a specific miRNA–receptor regulatory axis that could be targeted to treat AD-related sphingolipid dysregulation.

Wu W, Zhang Z, Zhou B et al. · Phytomedicine : international journal of phytotherapy and phytopharmacology · (2026) · View on PubMed ↗

Activation of the Lactate Receptor GPR81 Ameliorates Senescence Hallmarks and Improves Muscle Function in Cellular and Progeroid Models of Aging.

This study investigated whether activating the lactate receptor GPR81 can reverse senescence and improve muscle function in cellular and progeroid models of aging. Loss of GPR81 impaired lipid oxidation and increased lipid accumulation, senescence markers (DNA damage, ROS), mitochondrial dysfunction, and defective autophagy, whereas GPR81 agonist treatment enhanced lipid oxidation, reduced lipid accumulation, and decreased senescence hallmarks. Scientifically, it positions the GPR81–lactate signaling pathway as a potential therapeutic lever to mitigate age-associated muscle dysfunction driven by lipotoxicity and cellular senescence.

Mehrotra P, Bhamidipati SH, Lei P et al. · Aging cell · (2026) · View on PubMed ↗ · Free PDF ↗

Ambient temperature reduces oocyte yield in assisted reproductive technology via a partially sex hormone-mediated pathway.

This study examined whether higher ambient temperatures before oocyte retrieval affect oocyte yield in women undergoing their first IVF or ICSI cycle, focusing on a partially sex hormone-mediated pathway. Higher pre-retrieval temperatures were associated with reduced oocyte yield, with mediation involving LH and partial compensation via increased FSH and estradiol (E2). These findings suggest that controlling pre-retrieval thermal conditions and monitoring LH/FSH/E2 dynamics could improve assisted reproductive technology outcomes.

Zeng YY, Hu YL, Liu RL et al. · Human reproduction (Oxford, England) · (2026) · View on PubMed ↗

The Dual Role of Uric Acid: Pathological Implications Across Chronic Diseases and Current Approaches to Hyperuricemia Management.

This narrative review summarized the dual roles of uric acid in chronic diseases and current strategies for managing hyperuricemia, emphasizing mechanisms linking hyperuricemia to oxidative stress, endothelial injury, inflammation, and neurodegeneration. The key finding was that chronic hyperuricemia is broadly associated with cardiovascular, renal, metabolic, autoimmune, and CNS pathology, while uric acid can also exert antioxidant/neuroprotective effects under certain conditions. The clinical significance is that hyperuricemia management should be considered in a disease-context–dependent manner, balancing potential benefits and harms.

Zehra A, Asghar A, Ali S et al. · Discoveries (Craiova, Romania) · (2026) · View on PubMed ↗ · Free PDF ↗

Unraveling the Impact of Serum Zinc Levels on Chronic Kidney Disease: Machine Learning and SHAP Value Interpretation.

This cross-sectional analysis used NHANES 2011–2016 data to evaluate associations between serum zinc levels and prevalent chronic kidney disease (CKD) in U.S. adults, applying machine-learning models and SHAP value interpretation for feature importance. The key finding was that serum zinc levels were meaningfully associated with prevalent CKD and that the machine-learning/SHAP approach clarified zinc’s predictive relevance alongside other variables. Scientifically, the study supports zinc as a potential biomarker and demonstrates interpretable ML methods for CKD risk modeling in general populations.

Liu X, Zhao K, Li N et al. · Food science & nutrition · (2026) · View on PubMed ↗ · Free PDF ↗

Effects of exercise on reproductive endocrine hormones in adult patients with polycystic ovary syndrome: a systematic review and three-level meta-analysis.

This systematic review and three-level meta-analysis evaluated randomized controlled trials of exercise interventions on reproductive endocrine hormone outcomes in adult patients with polycystic ovary syndrome (PCOS). The key finding was that exercise produced measurable changes in reproductive endocrine profiles compared with control, with effect sizes synthesized across trials. Clinically, the results support exercise as an evidence-based adjunct to improve hormonal dysfunction in adult PCOS patients.

Chen X, Liu Y, Chen D et al. · PeerJ · (2026) · View on PubMed ↗ · Free PDF ↗

Intensive multimodal ketogenic metabolic therapy in glioblastoma: A clinical trial.

This clinical trial studied an intensive multimodal ketogenic metabolic therapy program (MTP) added to standard chemoradiation and adjuvant chemotherapy in newly diagnosed IDH-wildtype glioblastoma (GBM) patients. The key finding was feasibility/tolerability with the primary endpoint defined as maintaining a mean daily glucose ketone index (GKI) ≤6 during treatment, suggesting the metabolic regimen could be sustained alongside standard care. If confirmed in full results, this approach could provide a practical metabolic adjunct to improve outcomes in IDH-wildtype GBM by targeting tumor-relevant glucose/ketone metabolism.

Phillips MCL, Thotathil Z, Haji Mohd Yasin NAB et al. · Neuro-oncology advances · (2026) · View on PubMed ↗ · Free PDF ↗

GSK3B variations influence renoprotective responses to dapagliflozin in diabetic kidney disease.

This study investigated why dapagliflozin shows variable renoprotective effects in type 2 diabetic kidney disease by testing the role of GSK3B (GSK3β) in mediating nephroprotection. The key finding was that GSK3β directly bound and was partially inhibited by dapagliflozin, and that GSK3β activity influenced podocyte protection, with GSK3B genetic variation associated with differences in urinary protein-lowering responses. Scientifically and clinically, it identifies GSK3β as a mechanistic mediator and suggests that GSK3B variation could help predict who benefits most from dapagliflozin.

Song J, Xu Y, Zhuang Y et al. · iScience · (2026) · View on PubMed ↗ · Free PDF ↗

A Comparative Study of the Effects of Allantoin and Metformin on Blood Sugar Levels and Body Weight in Streptozotocin-Induced Diabetic Wistar Rats.

This randomized controlled in vivo study compared allantoin (5 or 10 mg/kg), metformin (500 mg/kg), and their combination on blood glucose and body weight in low-dose streptozotocin (STZ)-induced diabetic Wistar rats. The key finding was that allantoin and/or metformin altered glycemic control and body-weight outcomes in the diabetic rat model, with effects assessed across the different dosing regimens and combinations. If translatable, these results support further evaluation of allantoin as a potential adjunct or alternative to metformin for managing diabetes-related metabolic dysfunction.

Gargate PR, Khanwelkar C, Thorat VM et al. · Cureus · (2026) · View on PubMed ↗ · Free PDF ↗

Metabolic implications of hepatic, pancreatic and abdominal adipose tissue depots in Asian Indians across normoglycaemia, prediabetes and type 2 diabetes.

This cross-sectional study examined metabolic implications of hepatic, pancreatic, and abdominal adipose tissue depots in Asian Indians across normoglycaemia, prediabetes, and newly diagnosed type 2 diabetes, matched for BMI. Using multi-echo chemical-shift-encoded MRI (CSE-MRI) with proton density fat fraction (PDFF) for liver and pancreas and MRI for abdominal fat compartments, the key finding was that specific fat depots and their distributions were associated with dysglycaemia-related metabolic changes and could serve as predictors. Scientifically and clinically, it suggests that depot-specific ectopic fat measures may help identify individuals at risk for progression along the dysglycaemia spectrum.

Ghosh A, Dutta K, Bhatt SP et al. · Diabetologia · (2026) · View on PubMed ↗

Is MASLD an independent risk factor for micro- and macrovascular complications of diabetes? A critical reappraisal and future directions.

This critical review studied whether metabolic dysfunction-associated steatotic liver disease (MASLD), including steatohepatitis (MASH) with fibrosis ≥F2, independently predicts micro- and macrovascular complications in diabetes. The key finding is that observational evidence is mixed and confounded by shared metabolic risk factors, so the independence of MASLD as a risk factor remains uncertain and requires better causal inference. This is significant because it outlines future research directions—such as improved adjustment and longitudinal designs—to clarify whether MASLD should be targeted to reduce diabetic vascular complications.

Kahl S, Caussy C, Cusi K · Diabetologia · (2026) · View on PubMed ↗

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Inflammation, Autoimmunity & Immunological Mechanisms

Milk osteopontin alters the infant microbiome to drive DC hematopoiesis and disease tolerance.

This mouse study investigated how milk osteopontin (OPN) shapes the infant microbiome to drive dendritic cell (DC) hematopoiesis and disease tolerance during severe lower respiratory infections. It found that absence of milk-derived OPN predisposed neonatal mice to viral and bacterial sLRIs via disrupted DC hematopoiesis in developing liver and lung, while oral OPN supplementation increased Lactobacillaceae abundance and serum 3-phenyllactic acid (PLA), a PPARγ agonist, with disease amelioration also supported by PLA supplementation. The significance is that milk OPN–microbiome–PLA/PPARγ signaling may represent a mechanistic, potentially translatable nutritional strategy to enhance infant immune tolerance and reduce infection severity.

Howard DR, Rashid RB, Ahmed T et al. · Cell · (2026) · View on PubMed ↗

Neonatal Medical Male Circumcision and Child Autism Diagnosis.

This prospective cohort study within the ECHO (Environmental Influences on Child Health Outcomes) network examined whether neonatal medical male circumcision (NMC) is associated with later child autism spectrum disorder (ASD) diagnosis and autism-related traits/behaviors in male singleton children. The key finding was not available from the provided abstract text (the results section is truncated). If confirmed, the study would clarify whether NMC is causally or non-causally related to ASD risk, informing counseling and public health guidance.

McGrath M, Li X, Jacobson LP et al. · JAMA pediatrics · (2026) · View on PubMed ↗

Where is the sweet spot for psychedelic-enhanced fear extinction? An integrative quantitative synthesis of dose-effect patterns in rodent models.

This integrative quantitative synthesis analyzed rodent studies to determine the dose–effect “sweet spot” for psychedelic-enhanced fear extinction using regression-based cross-study modeling. The key finding was not included in the provided truncated abstract text, so the specific dose–response pattern (e.g., linear vs bell-shaped) cannot be determined here. If clarified, the results would help optimize dosing regimens for preclinical fear-extinction paradigms relevant to anxiety and stress-related disorders.

Werle I, Probst MEC, Bertoglio LJ · Journal of psychopharmacology (Oxford, England) · (2026) · View on PubMed ↗

High prevalence of iron deficiency among daratumumab-treated newly diagnosed multiple myeloma patients.

This retrospective case-control study evaluated iron deficiency prevalence in newly diagnosed multiple myeloma patients treated with daratumumab-based therapy (Dara-IRD: daratumumab, ixazomib, lenalidomide, dexamethasone; n=55). It found that iron deficiency is highly prevalent among daratumumab-treated newly diagnosed MM patients, indicating that iron deficiency may be an underrecognized contributor to anemia in this setting. Clinically, the results support routine assessment and management of iron deficiency in daratumumab-treated MM to address potentially modifiable causes of anemia.

Hwa YL, Jevremovic D, Pak K et al. · British journal of haematology · (2026) · 2 citations · View on PubMed ↗ · [Free PDF ↗](https://ashpublications.org/blood/article-pdf/142/Supplement 1/3337/2191489/blood-9939-main.pdf)

Mineralocorticoid receptor overactivation in heart failure with preserved ejection fraction.

This article discusses mechanisms of mineralocorticoid receptor (MR) overactivation in heart failure with preserved ejection fraction (HFpEF), focusing on how conventional HFpEF risk factors can drive MR activation. It highlights under-recognized pathways including renin-independent aldosterone excess, cortisol dysregulation, and ligand-independent MR activation that may link comorbidities to HFpEF pathophysiology. Scientifically, it frames MR as a mechanistic target in HFpEF and motivates more precise therapeutic strategies aimed at MR-driven disease biology.

Kobayashi M, Pitt B, Zannad F · European heart journal · (2026) · View on PubMed ↗

Treatment Persistence of Interleukin-17 Inhibitors and Factors Associated with Persistence in Patients with Psoriasis Vulgaris in Japan: Retrospective Database Study.

This retrospective database study assessed treatment persistence of IL-17 inhibitors (ixekizumab, secukinumab, brodalumab, or bimekizumab) and factors associated with persistence in Japanese patients with psoriasis vulgaris. Using the Medical Data Vision database, it evaluated real-world long-term persistence patterns for IL-17 biologics and analyzed patient or treatment factors linked to continued therapy. The findings are clinically important for optimizing long-term biologic management and improving outcomes in moderate-to-severe psoriasis in Japan.

Tada Y, Kagitani H, Kimura S et al. · Dermatology and therapy · (2026) · View on PubMed ↗ · Free PDF ↗

Targeting the immune-metabolic axis reverses orthodontics-induced systemic pathology.

The study examined how mechanical force during orthodontic treatment affects systemic immune-metabolic pathology in vivo, focusing on adaptive immune responses and B-cell activation. Orthodontic force induced systemic inflammation with temporary liver dysfunction characterized by expansion of CD69+ B cells, and IgM from these activated B cells acted as a key pathogenic driver impairing bone repair at distant sites. These findings suggest that targeting the immune-metabolic axis—specifically pathogenic IgM-producing CD69+ B cells—may be a strategy to prevent systemic complications of orthodontic therapy.

Zhang Y, Jiang S, Zheng H et al. · Signal transduction and targeted therapy · (2026) · View on PubMed ↗ · Free PDF ↗

Opportunities for Pediatricians to Address Racism and Bias to Reduce Racial Disparities in Breastfeeding and the Use of Human Milk: Policy Statement.

The study (policy statement) addressed how pediatricians can reduce racial disparities in breastfeeding and human milk use in the US. It highlighted evidence-based actions including partnerships with community health workers, culturally centered hospital practices, fair payment for lactation services and supplies, discouraging formula marketing in clinical settings, and ongoing clinician learning across cultures. The significance is that it provides actionable guidance for clinical and institutional interventions to improve equity in breastfeeding outcomes.

Feldman-Winter L, Long S, Ware J et al. · Pediatrics · (2026) · View on PubMed ↗

Effect of Abrocitinib on the Skin Microbiome in Patients With Moderate-to-Severe Atopic Dermatitis.

This randomized, placebo-controlled study assessed the effect of abrocitinib, a Janus kinase 1 (JAK1)-selective inhibitor, on the skin microbiome and clinical outcomes in patients with moderate-to-severe atopic dermatitis enrolled in JADE MOA (NCT03915496). Using 16S rRNA gene amplicon sequencing of skin swabs at baseline and Weeks 2, 4, and 12, the trial evaluated how abrocitinib (100 mg or 200 mg once daily) altered microbial composition alongside changes in disease severity. The results are significant because they connect targeted JAK1 inhibition to microbiome modulation in AD, potentially explaining part of abrocitinib’s clinical benefit in dysbiosis-associated inflammation.

Kim M, Del Duca E, Correa Da Rosa J et al. · Allergy · (2026) · View on PubMed ↗

Vitamin D in mucosal healing: therapeutic potential and current evidence in inflammatory bowel disease.

This therapeutic review discussed the role of mucosal healing (MH) in inflammatory bowel disease (IBD) and evaluated evidence for interventions targeting MH, emphasizing the gap between clinical indices and direct endoscopic/histologic assessment. The key finding was that MH is a validated therapeutic target linked to improved outcomes, but current studies often rely on indirect measures rather than standardized endoscopic or histologic endpoints. The clinical significance is that future IBD trials should better align treatment evaluation with objective MH assessment to guide more effective mucosa-restoring therapies.

Scaff V, Vallejos OP, Silva PH et al. · Therapeutic advances in gastroenterology · (2026) · View on PubMed ↗ · Free PDF ↗

Potential preventive role of low-dose methotrexate against incident recorded psychosis: a retrospective cohort study based on electronic health records.

This retrospective cohort study used electronic health records from the TriNetX US Collaborative Network to evaluate whether low-dose methotrexate reduces incident recorded psychosis in adults with rheumatoid arthritis (age ≤45 at initiation) and compared it with other immune-related conditions and other DMARDs. The key finding was the real-world association between low-dose methotrexate exposure and risk of incident psychosis (and related immune-linked psychiatric outcomes) in this population. If causal mechanisms are supported, it would strengthen the hypothesis that immune modulation with low-dose methotrexate may have preventive antipsychotic effects.

Corsi-Zuelli F, Taquet M, Deakin B et al. · EClinicalMedicine · (2026) · View on PubMed ↗ · Free PDF ↗

STIM1-mediated Treg instability in HFpEF: a new immunological target emerges?

This article discusses stromal interactome mechanisms of regulatory T cell (Treg) instability in heart failure with preserved ejection fraction (HFpEF), highlighting the role of STIM1 in Treg dysfunction. The key finding is that STIM1-mediated signaling contributes to Treg instability, which may drive the inflammatory phenotype characteristic of HFpEF. Clinically, this positions STIM1 as a potential immunological target to restore Treg stability and mitigate HFpEF-associated inflammation.

Planavila A, Blasco-Roset A · Cardiovascular diabetology · (2026) · View on PubMed ↗ · Free PDF ↗

Non-immunoglobulin E-mediated mechanisms of anaphylaxis.

This review studied non-immunoglobulin E (IgE)-mediated mechanisms of anaphylaxis, synthesizing recent evidence on IgE-independent pathways relevant to diagnosis and therapy. It highlights that the Mas-related G protein-coupled receptor X2 (MRGPRX2) is a central mediator of IgE-independent drug reactions, expanding the mechanistic framework beyond classic IgE allergy. Scientifically and clinically, these insights support more precise risk stratification and targeted interventions for anaphylaxis cases not driven by IgE.

Cardona V, Sala-Cunill A · Current opinion in allergy and clinical immunology · (2026) · View on PubMed ↗

A global OMERACT ultrasound joint damage scoring system (GLODS) in rheumatoid arthritis.

This study developed and tested a global OMERACT ultrasound joint damage scoring system (GLODS) for rheumatoid arthritis (RA) by using a Delphi consensus process to define semiquantitative scoring for structural damage components (bone erosions, cartilage change, and joint malalignment) and then assessing reliability of individual components. The key finding was that consensual definitions and semiquantitative scoring for the three structural damage domains can be operationalized for RA ultrasound and show reliability suitable for use in research. The resulting GLODS framework standardizes ultrasound-based structural damage measurement, improving comparability across studies and potentially supporting treat-to-target assessment.

Mandl P, Gessl I, Kun L et al. · Annals of the rheumatic diseases · (2026) · View on PubMed ↗ · Free PDF ↗

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Fibrosis & Organ-Specific Inflammatory Remodeling

Apoptosis of Mdm2-deficient osteocytes enhances osteogenesis through TRPM8-enriched apoptotic vesicles.

The study investigated how conditional deletion of Mdm2 in osteocytes affects bone formation, using single-cell RNA sequencing and analysis of apoptotic vesicles in mice. Although Mdm2-deficient osteocytes underwent apoptosis, the mice showed increased bone mass due to enhanced osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs), with calcium-related pathways enriched and TRPM8-enriched apoptotic vesicles implicated in the pro-osteogenic signaling. Scientifically, it reframes osteocyte apoptosis as a potential regulator of osteogenesis and identifies TRPM8-enriched apoptotic vesicles as a mechanistic link to bone gain.

Liu X, Zheng H, Wang A et al. · Bone research · (2026) · View on PubMed ↗ · Free PDF ↗

BCL9 inhibition promotes fibroblast lipogenesis by regulating macrophage-fibroblast interactions to attenuate pulmonary fibrosis.

The study evaluated whether inhibiting BCL9 can attenuate idiopathic pulmonary fibrosis by modulating macrophage-fibroblast crosstalk, focusing on the MerTK-ERK-SPP1 signaling axis and fibroblast lipogenesis. BCL9 promoted the macrophage M2 program via the MerTK-ERK-SPP1 axis, and pharmacologic inhibition with the peptide hsBCL9Z96 reprogrammed macrophages and reduced pulmonary fibrosis. These results support BCL9 as a therapeutic target and position hsBCL9Z96 as a candidate strategy to treat IPF by disrupting pro-fibrotic immune–stromal interactions.

Wang W, Zhang Y, He F et al. · Signal transduction and targeted therapy · (2026) · View on PubMed ↗ · Free PDF ↗

ATP6AP2 ameliorates inflammation and pyroptosis in heart failure by promoting lysosome-dependent STING degradation.

This study tested whether ATP6AP2, a V-ATPase accessory subunit, protects against inflammation and pyroptosis in heart failure by promoting lysosome-dependent degradation of STING. Using a cardiac-specific ATP6AP2 conditional knockout (CKO) mouse model, the authors observed worsened cardiac dysfunction, fibrosis, and cardiomyocyte apoptosis, and mechanistically showed that ATP6AP2 enhanced STING degradation via the lysosomal pathway. These findings suggest ATP6AP2–STING axis modulation as a potential therapeutic strategy to reduce inflammatory signaling and pyroptosis in heart failure.

Zhao X, Zhang H, Ding X et al. · Apoptosis : an international journal on programmed cell death · (2026) · View on PubMed ↗

The changing epidemiology of primary liver cancer in the 21st century.

Using Global Burden of Disease (GBD) 2023 analyses, the study characterized 21st-century trends in primary liver cancer incidence and mortality worldwide, including changes in age-standardised rates and the contribution of viral hepatitis. It found that absolute cases and deaths increased substantially from 2000 to 2023, while age-standardised incidence and mortality declined until around 2020 before reversing, with hepatitis B and C remaining major contributors despite declining proportions. The findings emphasize the need for renewed surveillance and prevention strategies as epidemiologic gains from vaccination and antivirals appear to be plateauing or reversing.

Khan SA, Vithayathil M, Yip TCF et al. · Journal of hepatology · (2026) · View on PubMed ↗ · Free PDF ↗

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Gene Therapy, Molecular Targeting & Drug Discovery Tools

Rhoptry biogenesis in Plasmodium sporozoites is uncoupled from mitosis and forms distinct pairs.

This study investigated rhoptry biogenesis during Plasmodium sporozoite development and how it relates to mitosis, using mosquito tissue ultrastructure expansion microscopy (MoTissU-ExM) to preserve ultrastructure while expanding infected tissues. The key finding was that rhoptry formation is uncoupled from mitosis and occurs as distinct paired structures. Scientifically, it refines the cell biology of malaria transmission-stage organelle biogenesis, potentially informing strategies targeting invasion machinery.

Liffner B, Alves E Silva TL, Glennon E et al. · The Journal of cell biology · (2026) · View on PubMed ↗

Small molecule inhibitor of orphan GPCR dimerization improves host defense and blood pressure control in mice.

This preclinical mouse study examined whether inhibiting orphan GPCR dimerization in the GPRC5 family improves host defense and blood pressure control. The key finding was that disrupting the GPRC5B dimerization interface—via interface mutation or a decoy peptide—reduced EP2 signaling in macrophages, increased migration and phagocytosis, and protected mice from bacterial peritonitis; a similar interface in GPRC5C also responded to the same strategy. Scientifically and therapeutically, it supports small-molecule/peptide approaches that target GPCR dimerization as a dual-modality strategy for immune defense and vascular regulation.

Kwon J, Persechino M, Shao J et al. · The Journal of clinical investigation · (2026) · View on PubMed ↗ · Free PDF ↗

Adeno-Associated Virus-Mediated Central Nervous System Gene Transfer to Suppress Alzheimer’s Disease High-Risk APOE4 Variant and Replace with Protective APOE2.

This preclinical/translation-focused study describes adeno-associated virus (AAV)-mediated CNS gene transfer strategies to suppress the high-risk APOE4 variant and replace it with protective APOE2. Prior mouse work cited by the authors shows that AAV-delivered APOE2 is highly protective against APOE4 toxicity and that AAV delivery of anti-APOE4 microRNA (miRNA) suppresses APOE4 expression. These results support a gene-therapy approach for late-onset Alzheimer’s disease risk reduction by directly modulating APOE genotype expression in the CNS.

Karan KR, Hackett NR, Crystal RG · Human gene therapy · (2026) · View on PubMed ↗

Intron retention in health and amyotrophic lateral sclerosis.

This article reviewed intron retention (IR) in mammalian biology, focusing on how unspliced introns can be incorporated into mature mRNA and influence gene expression. It argues that IR has more complex and dynamic roles than previously assumed, extending beyond simple reduction of translation via mechanisms like nuclear detention or nonsense-mediated decay (NMD). Scientifically, clarifying IR’s regulation and functional consequences may help explain disease-relevant transcriptome changes, including in amyotrophic lateral sclerosis.

Wang CY, Taylor S, Pandya VA et al. · Brain : a journal of neurology · (2026) · View on PubMed ↗ · Free PDF ↗

D347G in PA is critical for the pathogenicity of H9N2 avian influenza A virus in mice.

This study investigated whether the naturally occurring D347G mutation in the H9N2 avian influenza A virus polymerase acidic (PA) protein affects pathogenicity in mice using the lethal isolate A/chicken/Jiangxi/198/2019 (JX198). The D347G change in PA was found to be critical for H9N2 virulence in mice, driving lethal disease phenotypes without prior adaptation. These findings identify a specific PA residue that can enhance mammalian pathogenic potential of H9N2, informing molecular surveillance and risk assessment of zoonotic influenza strains.

Zhao Z, Tian Y, Jiang W et al. · Virulence · (2026) · View on PubMed ↗ · Free PDF ↗

African swine fever virus pMGF360-3 L suppresses innate immunity by facilitating CMA-dependent SKP1 degradation to promote BNIP3-mediated mitophagy.

This study investigated how African swine fever virus (ASFV) protein pMGF360-3 L modulates host innate immunity and mitophagy by engaging chaperone-mediated autophagy (CMA) in infected cells. pMGF360-3 L promoted CMA-dependent degradation of SKP1, which increased BNIP3 levels by preventing proteasomal degradation of BNIP3 and thereby enhanced BNIP3-mediated mitophagy while suppressing type I interferon (IFN-β) production. These mechanistic insights identify a viral strategy linking CMA-mediated SKP1 turnover to immune evasion, offering potential intervention points for controlling ASFV.

Lin S, Liang J, Ye J et al. · Autophagy · (2026) · View on PubMed ↗

Effects of BPC-157 and TB-500 on Achilles tendon healing in rats: A histopathological and biomechanical study.

This rat experimental study tested BPC-157 (10 µg/kg/day), TB-500 (60 µg/kg/day), or their combination on Achilles tendon healing after standardized transection and repair, using biomechanical testing plus histopathological, histochemical, and immunohistochemical analyses. The key finding was that BPC-157 and/or TB-500 (and the combination) improved tendon healing outcomes compared with controls across the evaluated tissue and functional measures. Preclinically, these results support further investigation of BPC-157 and TB-500 as potential pro-regenerative therapies for tendon repair.

Biçer O, Adanir O, Güleryüz Y et al. · Joint diseases and related surgery · (2026) · View on PubMed ↗ · Free PDF ↗

Evaluating exon skipping in the central nervous system in Duchenne muscular dystrophy using spatial transcriptomics.

This study used spatial transcriptomics to map Dmd (dystrophin) isoform expression across mouse brain regions and cell types, and tested whether exon 51-skipping therapy in Mdx52 mice restores the Dp427-sized dystrophin isoform at transcript and protein levels. The key finding was that dystrophin isoforms show region- and cell-type-specific patterns in the CNS and that exon 51-skipping can reconstitute the Dp427-sized isoform in vivo. These results support exon-skipping strategies as a route to restore dystrophin in the CNS for Duchenne muscular dystrophy and provide a cell-resolved atlas to guide dystrophin-restoring drug development.

Mao Q, Ahmadi A, de Vries S et al. · iScience · (2026) · View on PubMed ↗ · Free PDF ↗

Retraction Notice to: Gene Silencing of Transferrin-1 Receptor as a Potential Therapeutic Target for Human Follicular and Anaplastic Thyroid Cancer.

This is a retraction notice for the previously published article “Gene Silencing of Transferrin-1 Receptor as a Potential Therapeutic Target for Human Follicular and Anaplastic Thyroid Cancer.” The key finding is that the earlier work is withdrawn from the literature. Scientifically, this signals that evidence regarding transferrin receptor (TFR1/CD71)-targeted gene silencing in thyroid cancer should no longer be considered reliable.

Campisi A, Bonfanti R, Raciti G et al. · Molecular therapy. Oncology · (2026) · View on PubMed ↗ · Free PDF ↗

Accurately modeling RNase H-mediated antisense oligonucleotide efficacy.

This work developed a computational approach to predict RNase H-mediated antisense oligonucleotide (ASO) efficacy by training a deep learning model (OligoAI) using ASO Atlas, a database of 188,521 RNase H-mediated ASO sequences targeting 334 genes with knockdown efficacy measurements from patents. The key finding was that OligoAI can jointly model RNA target context, ASO sequence, and sugar/backbone chemistries to improve efficacy prediction without requiring large experimental screens for every target. This is significant for accelerating ASO drug discovery by enabling more efficient in silico candidate selection for RNase H-dependent therapies.

Hill B, Jaques MR, Nair RR et al. · Molecular therapy. Nucleic acids · (2026) · View on PubMed ↗ · Free PDF ↗

RNF187 inhibits porcine reproductive and respiratory syndrome virus replication by recruiting the autophagy receptor NDP52 to degrade nsp12.

This study investigated the porcine host restriction mechanism of the E3 ubiquitin ligase RNF187 against porcine reproductive and respiratory syndrome virus (PRRSV) in porcine cells, focusing on viral nonstructural protein 12 (nsp12). RNF187 directly interacts with nsp12 and inhibits PRRSV replication by recruiting the autophagy receptor NDP52 to promote degradation of nsp12, with RNF187 knockdown enhancing viral replication. These findings identify an RNF187–NDP52 autophagy axis as a potential antiviral target to suppress PRRSV replication by eliminating a key replication factor.

Wang Q, Zheng G, Tian T et al. · Veterinary research · (2026) · View on PubMed ↗ · Free PDF ↗

Site-Specific Chemical Conjugation of Recombinant Proteins onto the AAV Capsid.

This Methods in Molecular Biology article studied a technique for site-specific chemical conjugation of recombinant proteins onto adeno-associated virus (AAV) capsids. The key finding is that by encoding a bioorthogonal chemical handle into selected capsid proteins using noncanonical amino acid (ncAA) mutagenesis, researchers can attach full-length proteins (e.g., antibodies) with precise control over attachment site and stoichiometry. Scientifically, this provides a generalizable platform to engineer AAV capsids with improved tissue targeting and potentially reduced off-target effects at lower doses.

Pham Q, Glicksman J, Chatterjee A · Methods in molecular biology (Clifton, N.J.) · (2026) · View on PubMed ↗

Rocaglates and pateamines target the DEAD-box RNA helicase eIF4A from Schistosoma mansoni and demonstrate anti-schistosomal activity in vitro.

This study investigated whether rocaglates and pateamines can inhibit the DEAD-box RNA helicase eIF4A from Schistosoma mansoni and thereby exert anti-schistosomal activity in vitro. The key finding is that these compounds target eIF4A and prevent its unwinding of structured 5′-UTR RNA elements required for translation initiation, impairing parasite protein synthesis. This is significant because it supports eIF4A as a druggable target and provides candidate compounds for developing alternatives to praziquantel.

Welsch S, Magari F, Mokosch AS et al. · Scientific reports · (2026) · View on PubMed ↗ · Free PDF ↗

Mosapride promotes internalization of a TREK1-HTR4 complex and exerts rapid antidepressant-like effects.

The authors investigated how the prokinetic drug mosapride affects trafficking and function of a TREK1–HTR4 (two-pore domain potassium channel TREK1 and serotonin receptor HTR4) complex, using a cell-based biomolecular luminescence complementation (BiLC) screening platform to monitor membrane-associated TREK1. Mosapride promoted internalization of the TREK1–HTR4 complex and produced rapid antidepressant-like effects in their experimental system. This mechanistic link between mosapride, TREK1/HTR4 complex trafficking, and fast antidepressant-like activity supports a GPCR–ion channel regulatory model for developing next-generation rapid-acting antidepressants.

Lee S, Kim SC, Noh J et al. · Molecular psychiatry · (2026) · View on PubMed ↗ · Free PDF ↗

Particle engineering, aerosol physics, and pulmonary deposition of single-inhaler triple ICS/LABA/LAMA therapies in obstructive airway diseases.

The study compared particle engineering and aerosol physics across approved single-inhaler triple therapy (SITT) device platforms delivering different ICS/LABA/LAMA combinations, focusing on pulmonary deposition of single inhaler formulations in obstructive airway diseases. It found that device platform and particle characteristics (e.g., extrafine versus standard-particle formulations and specific inhaler technologies) meaningfully influence aerosol delivery to the lungs. Scientifically and clinically, these results support selecting inhaler devices based on deposition performance to optimize drug delivery in COPD and severe uncontrolled asthma.

Sorino C, Virchow JC, Spanevello A et al. · European journal of internal medicine · (2026) · View on PubMed ↗

Universally offered germline testing in upper tract urothelial carcinoma.

In a retrospective single-institution cohort of UTUC patients offered germline testing universally (2020–2025, regardless of hereditary cancer suspicion), the study assessed the prevalence and spectrum of pathogenic germline variants (PGVs) and compared germline findings with immunohistochemistry-based Lynch syndrome (MMR-D) screening. Universally offered germline testing identified a measurable burden of PGVs in UTUC, including cases that might be missed by tissue- and clinical-based screening alone. This supports implementing broad germline testing in UTUC to improve Lynch syndrome detection and downstream risk management for patients and families.

Spooner JT, Igel DA, Labbate CV et al. · Urologic oncology · (2026) · View on PubMed ↗

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Generated automatically on August 04, 2026 from PubMed’s trending articles. Summaries are AI-generated; always consult the original publication for clinical or research decisions.