PubMed Trending Research Digest — August 17, 2026

Automated digest · 96 articles · 25 research areas · August 17, 2026

Overview

This week’s papers cluster around a shared translational theme: improving how therapies are delivered, targeted, and monitored by using mechanistic biology and better measurement. In oncology and immunology, multiple studies show that “response brakes” are often metabolic or microenvironmental—e.g., lactate-driven lactylation dampening STING signaling, lactylation reprogramming macrophage metabolism to suppress CD8+ T cells, and spatially distinct EMT invasion niches in HPV+ vs HPV− head and neck cancers. Complementing this, work on DNA repair dependencies (TBK1-driven HR suppression; Polθ/MMEJ defects in SMARCB1-loss tumors) and druggable transcriptional metabolic programs (EZH2–SREBP2–p300 cholesterol biosynthesis) points to more precise combination strategies and biomarkers.

A second dominant thread is “precision phenotyping” across diseases using AI, omics, and structured clinical frameworks. Examples include ML signatures for sarcopenia in type 2 diabetes muscle, AI models for ICU delirium prediction with explainability, and CT-based quantitative approaches for progressive ILD risk stratification. In Alzheimer’s disease, blood-based biomarker strategies (plasma p-tau217 with Aβ42) and highly sensitive tau-seed detection (PMCA) emphasize moving toward less invasive, earlier, and more scalable diagnosis/monitoring. In parallel, geriatrics and aging research highlights actionable risk pathways—frailty transitions and depression predicting dementia, and tissue “aging clocks” derived from histopathology—while clinical implementation/consensus papers stress that timing and operational feasibility (e.g., early CGA, asparaginase delivery) can be as important as the intervention itself.

Finally, several studies broaden the therapeutic toolkit beyond drugs alone: CNS-targeting lipid nanoparticles for mRNA across the BBB, engineered astrocyte/circuit concepts for future brain modulation, implantable sonothermal materials for localized heating, and synthetic microbial communities as controllable microbiome therapeutics. Together, these findings suggest a field-wide shift toward integrating delivery engineering, mechanistic checkpoints, and robust risk stratification to make interventions safer, more effective, and easier to deploy in real-world care.

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CNS drug delivery across the blood–brain barrier

Fusion of IgG antibodies to albumin inhibits transport across the placenta.

This study tested whether fusing IgG to albumin can reduce neonatal Fc receptor (FcRn)-mediated placental transport of IgG during pregnancy using mouse models and an ex vivo human placental perfusion system. IgG–albumin fusion markedly inhibited transplacental transport in both systems while preserving FcRn-dependent prolonged plasma half-life. The findings support albumin-fusion as a strategy to improve antibody safety and efficacy during pregnancy by limiting fetal exposure.

Nilsen J, Sand KMK, Al-Khabbaz HJ et al. · Science immunology · (2026) · View on PubMed ↗

Overcoming the blood-brain barrier using central nervous system-accessing lipid nanoparticles for enhanced mRNA therapeutics.

The study designed and tested CNS-accessing lipid nanoparticles (CA LNPs) formulated with ionizable lipids to deliver messenger RNA (mRNA) across the blood-brain barrier in wild-type mice, Ai14 reporter mice, and nonhuman primates. The lead CA2d LNP candidate enabled efficient intravenous mRNA delivery into multiple CNS cell types, including neurons, microglia, and astrocytes. This provides a translational platform for improving brain delivery of mRNA therapeutics for CNS diseases by overcoming BBB transport limits.

Wang S, Zhong Y, Wang C et al. · Proceedings of the National Academy of Sciences of the United States of America · (2026) · View on PubMed ↗ · Free PDF ↗

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Neurodegeneration & Alzheimer’s disease biomarkers/therapeutics

Restoration of Neuronal Metabolism and Memory in Alzheimer’s Disease by Reprogramming the Exosomal microRNA Network.

This study explored whether reprogramming the exosomal microRNA network can restore neuronal metabolism and memory in Alzheimer’s disease (AD). By targeting exosomal microRNA dysregulation, the approach aimed to correct metabolic and synaptic dysfunction underlying AD rather than focusing only on amyloid-β plaques and tau tangles. If validated experimentally, this exosomal microRNA reprogramming strategy could provide a mechanistically grounded therapeutic avenue for metabolic synaptic disorders in AD.

Anwer T, Verma A, Asiri A et al. · Journal of molecular neuroscience : MN · (2026) · View on PubMed ↗

Comparison of double-blind and open-label decline rates in lecanemab and donanemab trials in Alzheimer’s disease.

This study compared simulated decline trajectories from phase 3 Alzheimer’s disease trials of the anti-amyloid monoclonal antibodies lecanemab and donanemab, contrasting double-blind trial decline with open-label extension (OLE) patterns using mixed-effects models calibrated to Clarity-AD and TRAILBLAZER-ALZ 2 data. The key finding was that the apparent magnitude of benefit in open-label comparisons differed from what would be expected under double-blind conditions, highlighting how historical untreated-cohort comparisons can be influenced by selection and attrition bias. Scientifically, it clarifies how trial design and comparator choice affect inferred long-term efficacy for lecanemab and donanemab.

Dwivedi AK, Imbimbo BP, Abanto J et al. · BMJ neurology open · (2026) · View on PubMed ↗ · Free PDF ↗

Cross-Sectional and Longitudinal Diagnostic Performance of Plasma p-tau217 and p-tau217/Aβ42 in Alzheimer’s Disease.

This study assessed cross-sectional and longitudinal diagnostic performance of plasma phosphorylated tau (p-tau217) alone and combined with plasma Aβ42 against Aβ-PET positivity in 326 participants from the Alzheimer’s Disease Neuroimaging Initiative and 357 Chinese older adults from the Greater-Bay-Area Healthy Aging Brain Study. The combined plasma p-tau217/Aβ42 approach showed improved concordance/diagnostic accuracy relative to p-tau217 alone across cross-sectional and longitudinal evaluations. Clinically, this supports using blood-based p-tau217 and Aβ42 to better track Alzheimer’s disease pathology and potentially streamline diagnosis and monitoring.

Jiang M, Lan G, Zhu J et al. · Annals of neurology · (2026) · View on PubMed ↗

Amplification of seeding-competent tau aggregates by PMCA in human and experimental tauopathies.

This experimental study used protein misfolding cyclic amplification (PMCA) to amplify seeding-competent tau aggregates derived from brains of transgenic mice and human patients with tauopathies. PMCA efficiently amplified tau aggregates using complex substrates such as brain homogenates or cell lysates expressing aggregation-prone mutant tau. The work strengthens the scientific basis for PMCA as a highly sensitive assay for detecting trace misfolded tau seeds across tauopathies, with potential translational value for diagnostics and mechanistic studies.

Almela F, Belondrade M, Caillierez R et al. · Acta neuropathologica communications · (2026) · View on PubMed ↗ · Free PDF ↗

PLCG2 downregulation impairs synaptic function and increases Alzheimer’s disease hallmarks in neuronal cultures.

The study investigated how Alzheimer’s disease genetic risk affects synaptic mechanisms in rat primary neuronal cultures and human neuronal cultures by downregulating PLCG2 (phospholipase C gamma 2). It found that PLCG2 downregulation disrupts dendritic morphology and synaptic function and increases amyloid-β (Aβ) levels and Tau phosphorylation in human neuronal cultures, with very rare PLCG2 loss-of-function variants (including R953*) associated with ~10-fold increased AD risk. This supports PLCG2 as a causal AD risk gene and highlights PLCG2/PLCγ2–dependent synaptic maintenance as a potential therapeutic target.

Coulon A, Rabiller F, Takalo M et al. · Nature genetics · (2026) · View on PubMed ↗ · Free PDF ↗

The future of blood-based biomarkers in liver cancer.

The article reviewed the current state and future prospects of blood-based (liquid) biomarkers in liver cancer, focusing on applications such as risk stratification, surveillance, early detection, and treatment monitoring. It concluded that while some cell-free DNA–based detection of actionable alterations has entered clinical practice, most candidate liquid biomarkers still lack prospective clinical validation and require translational evaluation embedded in clinical trials and prospective cohorts. This frames the key evidence gap—prospective validation—for advancing liquid biopsy into routine liver cancer care.

Singal AG, Saborowski A, Parikh ND et al. · Journal of hepatology · (2026) · View on PubMed ↗

Iatrogenic cerebral amyloid angiopathy: a scoping review.

This scoping review systematically characterized published iatrogenic cerebral amyloid angiopathy (iCAA) cases, focusing on geographic distribution, age-related clinical spectrum, and Japan’s contribution using PRISMA-guided searches of MEDLINE, Scopus, and Ichushi-Web up to 31 Jan 2026. The key finding is a structured synthesis of how iCAA presentations vary by age and region across the growing case literature. Clinically, this helps clinicians recognize iCAA risk patterns and better anticipate age-dependent manifestations after iatrogenic exposures.

Ikeda S, Hamaguchi T, Hirano T et al. · Journal of neurology, neurosurgery, and psychiatry · (2026) · View on PubMed ↗ · Free PDF ↗

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Neuroinflammation & neuroimmune regulation

Brain perivascular macrophages regulate endothelial cell function via a cMAF-dependent transcriptional program in mouse and human.

This study investigated how brain perivascular macrophages regulate endothelial cell function in mouse and human, focusing on the transcription factor cMAF, using single-cell multi-omics and in vivo conditional cMAF deletion. cMAF was identified as a key regulator that drives an IGF1 expression program in perivascular macrophages, enabling macrophage–endothelial communication and maintaining cerebral artery transcriptional and vascular function. These findings position cMAF–IGF1 signaling as a mechanistic target for preserving or restoring neurovascular function in health and disease.

Brioschi S, Belk JA, Storck SE et al. · Cell · (2026) · View on PubMed ↗ · Free PDF ↗

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Brain engineering & astrocyte/neuronal circuit tools

Astrocyte engineering.

This review studied the concept of “astrocyte engineering,” proposing engineered molecular access, sensing, and effector modules in astrocytes to interrogate or modify brain states. It summarizes how astrocyte interface biology can be converted into engineering logic using genetic access and signaling perturbation approaches. The scientific significance is that it provides a framework for designing targeted astrocyte-based tools for research and potentially for brain repair and modulation.

Motoyoshi M, Nagai J · Neuroscience research · (2026) · View on PubMed ↗

An octopamine-glutamate cotransmitting neuron gates aggressive escalation through layered inhibition in Drosophila.

This study used Drosophila melanogaster neural circuit approaches to define how an octopamine–glutamate cotransmitting neuron (Ventral paired medial 4, VPM4) controls aggressive escalation through layered inhibition. It found that VPM4 drives escalation gating via its downstream GABAergic target MBON-11, with octopamine and glutamate release independently regulated by presynaptic OAα2R and mGluR receptors. The work provides a transmitter-specific synaptic mechanism for how inhibitory circuitry constrains high-intensity aggression.

Prunier A, Sherer LM, Da Silva M et al. · Science advances · (2026) · View on PubMed ↗ · Free PDF ↗

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Stroke & ischemic brain injury resolution

Extracellular CIRP Dysregulates Microglial Efferocytosis in Acute Ischemic Stroke via the TLR4/miR-155/MafB Axis.

This study examined the role of extracellular cold-inducible RNA-binding protein (eCIRP) in microglial efferocytosis during acute ischemic stroke using a transient middle cerebral artery occlusion (tMCAO) mouse model. In tMCAO, eCIRP was released into cerebrospinal fluid and microglial MerTK efferocytic receptor expression decreased, while CIRP deficiency improved efferocytosis and reduced neuroinflammation via a TLR4/miR-155/MafB regulatory axis. These findings link eCIRP–TLR4 signaling to impaired microglial clearance of dying cells and suggest that targeting this axis could promote resolution of inflammation after ischemic stroke.

Lapin D, Aylar D, Sharma A et al. · Advanced science (Weinheim, Baden-Wurttemberg, Germany) · (2026) · View on PubMed ↗

DWI-Positive Lesions in Patients With Acute Intracerebral Hemorrhage: Associations With Cerebral Small Vessel Disease and Clinical Outcome.

This prospective cohort study investigated diffusion-weighted imaging (DWI)-positive lesions in acute intracerebral hemorrhage (ICH) and their associations with cerebral small vessel disease (cSVD) features and 6-month functional outcome measured by modified Rankin Scale (mRS). The key finding is the characterization of prevalence and anatomical distribution of DWI-positive lesions and their clinical-radiologic and prognostic associations, with specific results truncated in the provided abstract. These data support DWI-positive lesions as potential imaging biomarkers for cSVD burden and outcome prediction after ICH.

Locatelli M, Ozkan H, Avola G et al. · Neurology · (2026) · View on PubMed ↗ · Free PDF ↗

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Cancer immunotherapy & innate immune signaling (STING/IFN)

Lactate-Induced K370 Lactylation of STING Inhibits STING-TBK1 Signaling and Dampens Anti-Tumor Immunity.

This work investigated how tumor metabolism regulates innate immune signaling by studying lactate-driven post-translational modification of STING in the context of anti-tumor immunity. The authors found that lactate induces K370 lactylation on STING, which weakens STING–TBK1 interaction and shifts ubiquitination toward K48-linked chains (reducing K63-linked ubiquitination), thereby limiting STING stability/oligomerization and dampening pathway activation. This identifies STING K370 lactylation as a metabolic checkpoint that could explain resistance to STING-targeted therapies and suggests lactylation/ubiquitination modulation as a strategy to restore anti-tumor immunity.

Wu Y, Wang J, Chen X et al. · Advanced science (Weinheim, Baden-Wurttemberg, Germany) · (2026) · View on PubMed ↗

Calibration of CAR signaling promotes asymmetric cell division to direct CAR-T cell fate and antitumor potency.

This study investigated how antigen engagement and CAR signaling strength regulate asymmetric cell division (ACD) in chimeric antigen receptor (CAR)-T cells, using engineered CAR-T systems to track fate outcomes. Antigen engagement induced ACD through polarized inheritance of the CAR immune synapse (CARIS), generating CARhigh progeny with a short-lived effector-like state and CARlow progeny with memory-like features, with CAR signaling strength acting as a tunable determinant of this bifurcation. The work supports calibrating CAR signaling to bias CAR-T fate toward persistence and improved antitumor potency, informing safer and more effective CAR-T design.

Shen X, Xu X, Jiang J et al. · Cell reports · (2026) · View on PubMed ↗

DNA hypomethylation identifying clinical benefit subgroup of small-cell lung cancer: multi-omics analysis of a phase II trial with durvalumab plus olaparib as maintenance therapy.

This multi-omics analysis of a multicenter, single-arm phase II trial tested durvalumab plus olaparib maintenance in extensive-stage small-cell lung cancer (ES-SCLC) and used DNA hypomethylation to identify a clinical benefit subgroup. The key finding is that specific DNA hypomethylation patterns stratified patients into groups with differential clinical benefit during maintenance therapy. If validated, this provides a biomarker strategy to personalize durvalumab–olaparib maintenance and improve outcomes in ES-SCLC.

Zhao Y, Wang Q, Xiao B et al. · Journal for immunotherapy of cancer · (2026) · View on PubMed ↗ · Free PDF ↗

Selective decay of interferon mRNAs controls antiviral immunity and innate memory.

This mechanistic study investigated how interferon (IFN) mRNAs are kept low at baseline and rapidly normalized after stimulation. The authors found that tristetraprolin (TTP), together with mRNA decay machinery, selectively promotes post-transcriptional decay of type I and type III IFN mRNAs, and loss of this pathway increases poly(A) tail length, stability, and translation leading to elevated IFN expression. This provides a molecular explanation for homeostatic control of IFN signaling and how innate memory-like responses are regulated.

Braun RM, Ferretti MB, Lee JS et al. · Molecular cell · (2026) · View on PubMed ↗ · Free PDF ↗

A dendritic cell autophagy-neutrophil axis limits intratumoral STING immunotherapy.

This study investigated mechanisms limiting intratumoral STING agonist efficacy by using a mouse intratumoral delivery system that loads cyclic GMP-AMP (cGAMP) into virus-like particles (VLPs) to preferentially activate STING in dendritic cells, with mechanistic analyses of the resulting type I interferon signaling and T-cell priming. The work identifies a dendritic cell autophagy–neutrophil axis that constrains effective intratumoral STING immunotherapy. Clinically, defining this inhibitory circuit suggests combination approaches that relieve the autophagy/neutrophil brake to enhance responses to intratumoral STING agonists.

Loverre A, Jneid B, Delisle F et al. · Science immunology · (2026) · View on PubMed ↗

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Cancer cell-intrinsic DNA repair & genome maintenance

Liver regeneration CRISPR screen identifies E3 ligase NEURL1B regulates hepatocyte mitosis by destabilizing microtubule organizing centers.

This study used an in vivo CRISPRi screen in regenerating mouse liver to identify genes required for hepatocyte proliferation and focused on the E3 ligase NEURL1B. The key finding is that NEURL1B regulates hepatocyte mitosis during liver regeneration by destabilizing microtubule organizing centers, helping hepatocytes manage supernumerary centrosomes and mitotic errors. Scientifically, this links a specific ubiquitin ligase to centrosome/microtubule control in regeneration, suggesting NEURL1B as a mechanistic lever for improving regenerative outcomes.

Yin D, Vazquez Salgado AM, Cai C et al. · Gastroenterology · (2026) · View on PubMed ↗

Defective microhomology-mediated end joining in SMARCB1-deficient tumors.

This study analyzed DNA repair pathway dependencies in rhabdoid tumors driven by biallelic SMARCB1 loss, identifying a defect in microhomology-mediated end joining (MMEJ) and the role of DNA polymerase theta (Polθ/encoded by POLQ). SMARCB1-deficient tumors showed reduced Polθ protein maintenance via impaired nuclear export of POLQ mRNA, and loss of MMEJ triggered compensatory hyper-dependence on the Fanconi anemia (FA)/BRCA pathway. The findings suggest that targeting FA/BRCA signaling could be a therapeutic vulnerability in SMARCB1-deficient cancers.

Zhu G, Asada S, Nguyen H et al. · Science advances · (2026) · View on PubMed ↗ · Free PDF ↗

Inflammatory kinase TBK1 suppresses homologous recombination DNA repair to sensitize tumors to chemotherapy.

The study examined how inflammatory kinase TBK1 (TANK-binding kinase 1) affects homologous recombination (HR) DNA repair and thereby modulates sensitivity to chemotherapy in cancer cells. TBK1 activation increased chemotherapeutic efficacy by promoting DNA damage and impairing HR repair, independently of canonical inflammatory cytokine signaling as shown in IRF3- and p65-double deficient cells. This identifies TBK1 as a mechanistic lever to sensitize tumors to chemotherapy through DNA repair suppression.

Zhou W, Wang X, Steigleder SS et al. · Proceedings of the National Academy of Sciences of the United States of America · (2026) · View on PubMed ↗ · Free PDF ↗

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Cancer metabolism & lactylation/ferroptosis/polyamine pathways

Regulation and roles of mammalian mitophagy.

This review summarized current understanding of mammalian mitophagy, focusing on regulatory pathways that either depend on PINK1 and the E3 ubiquitin ligase Parkin (encoded by PRKN/PKRN) or proceed via PINK1/Parkin-independent mechanisms. It highlights that recessive mutations in PINK1 and PRKN cause early-onset Parkinson’s disease and have been instrumental in defining mitophagy biology. Scientifically, the synthesis clarifies how multiple mitophagy routes maintain mitochondrial integrity and suggests why defects can drive neurodegeneration.

Martens S, Ganley IG · Nature reviews. Molecular cell biology · (2026) · View on PubMed ↗

An EZH2-SREBP2 axis promotes cholesterol biosynthesis and represents a noncanonical vulnerability in tumorigenesis.

The study examined whether an EZH2–SREBP2 signaling axis regulates cholesterol biosynthesis and tumor growth, focusing on EZH2’s noncanonical transcriptional function. It found that EZH2 associates with SREBP2 to drive high expression of mevalonate pathway genes via p300-dependent transcriptional activation, enhancing cholesterol biosynthesis and sustaining tumorigenesis, and that PROTACs can target this EZH2 function as a vulnerability. This identifies a druggable metabolic dependency in cancer driven by the EZH2–SREBP2–p300 transcriptional program.

Kim A, Pan B, Yu X et al. · Nature cell biology · (2026) · View on PubMed ↗

YY1 lactylation mediates epithelial barrier dysfunction during acute lung injury.

This study investigated whether YY1 lactylation drives epithelial barrier dysfunction during acute lung injury (ALI) using ARDS patient samples and multiple ALI mouse models, with mechanistic perturbations including glycolysis inhibition and lactate manipulation. Inhibition of glycolysis with 2-deoxy-D-glucose (2-DG) reduced lactate-driven injury and improved alveolar epithelial barrier function, while exogenous lactate worsened barrier dysfunction, and genetic silencing experiments implicated YY1 lactylation as a mediator. These results support YY1 lactylation as a mechanistic link between lactate accumulation and barrier failure, suggesting lactate/YY1-pathway targeting as a potential therapeutic strategy in ALI/ARDS.

Li N, Liu Y, Gao M et al. · The European respiratory journal · (2026) · View on PubMed ↗

AARS1-mediated lactylation reprograms macrophage lipid metabolism to restrict antitumor immunity.

This study examined how AARS1-mediated lactylation reprograms macrophage lipid metabolism to suppress antitumor immunity in hepatocellular carcinoma (HCC), focusing on the immune cell population responsible for lactylation-driven immunosuppression. The key finding is that lactylation rewires macrophage metabolic programs via AARS1 to impair CD8+ T cell-mediated antitumor responses, thereby promoting immune evasion in HCC. These mechanistic insights identify AARS1/lactylation-linked macrophage metabolism as a potential target to restore antitumor immunity.

Xiao Z, Meng L, Xu S et al. · Journal for immunotherapy of cancer · (2026) · View on PubMed ↗ · Free PDF ↗

The GCN5L2-SIX1 complex drives glycolysis to promote progression of triple-negative breast cancer.

This study investigated how the GCN5L2-SIX1 axis drives lactylation-dependent glycolysis to promote progression of triple-negative breast cancer (TNBC), using molecular interaction and functional assays in TNBC cells. The key finding is that GCN5L2 physically interacts with SIX1, regulates SIX1 lactylation, promotes glucose uptake and glycolysis, and that GCN5L2 knockdown suppresses TNBC growth/migration and increases sensitivity to paclitaxel, with SIX1 overexpression reversing these effects. These results identify GCN5L2-mediated SIX1 lactylation as a metabolic vulnerability and potential therapeutic target in TNBC.

Liao Y, Yin S, Peng EY et al. · Cancer letters · (2026) · View on PubMed ↗

Polyamines buffer labile iron to suppress ferroptosis.

This study examined how polyamines influence ferroptosis susceptibility in mammalian cells, using a genome-wide CRISPR screen to probe genetic interactions with the ferroptosis suppressor GPX4. Polyamines were found to buffer labile redox-active iron and polyamine depletion created a synthetic lethal dependency with GPX4, linking polyamine metabolism to ferroptosis control. The work suggests that modulating polyamine–iron homeostasis could be a strategy to tune ferroptosis sensitivity therapeutically.

Sharma P, Keys HR, Mansell RP et al. · Cell · (2026) · View on PubMed ↗

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Cancer microenvironment, EMT, and spatial tumor architecture

Multi-Omics Integration Identifies a CDH3-Associated Malignant Epithelial State and Immunosuppressive Niche to Predict Prognosis in Thymic Epithelial Tumors.

This study integrated single-cell RNA sequencing, spatial transcriptomics, multiplex immunofluorescence, bulk transcriptomics, functional assays, xenografts, and computational pathology to define malignant epithelial states and immunosuppressive niches in thymic epithelial tumors (TETs). It identified a CDH3-associated malignant epithelial state at the origin of malignant-state trajectories, enriched for stem-like and EMT features, with CDH3+ tumor cells preferentially localized in immunosuppressive spatial niches. Clinically, this CDH3-associated state and niche organization improved prognosis prediction, providing a potential biomarker and microenvironmental target for stratifying and treating TETs.

Feng Y, Chen J, Xia L et al. · Advanced science (Weinheim, Baden-Wurttemberg, Germany) · (2026) · View on PubMed ↗

Spatial analysis of head and neck cancer identifies two ecosystems with distinct modes of epithelial-to-mesenchymal transition.

The study mapped tumor architecture and epithelial-to-mesenchymal transition (p-EMT) programs across HPV-positive and HPV-negative head and neck squamous cell carcinoma (HNSCC) using spatial transcriptomics (n=26). It identified two spatial ecosystems: a p-EMT edge driven by fibroblast–TGFβ coupling and a p-EMT core where immunosuppressive macrophages and neutrophils induce p-EMT via oncostatin M. These findings link microenvironmental cell states to distinct EMT spatial programs, suggesting more precise therapeutic targeting of TGFβ- versus oncostatin M–mediated invasion niches.

Simkin D, Barrett TF, Zhang L et al. · Nature genetics · (2026) · View on PubMed ↗

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Cancer targeted therapy & druggable molecular vulnerabilities

Identifying independent causal cell types for human diseases and risk variants.

This computational genomics study introduced cell-type fine-mapping methods (CT-FM and CT-FM-SNP) to identify independent causal cell-type sets and causal variants for complex traits using GWAS data and candidate regulatory element (cRE) annotations. Applying CT-FM to 63 GWASs with 924 cRE annotations inferred 79 independent cell-type sets explaining ~39% of trait SNP heritability and revealed traits with multiple independent cellular mechanisms (including height, schizophrenia, and autoimmune diseases). These methods can refine mechanistic interpretation of GWAS signals by pinpointing which cell types independently drive disease risk.

Kim A, Zhang ZE, Legros C et al. · Cell genomics · (2026) · View on PubMed ↗ · Free PDF ↗

Mechanism and plasticity of primitive pyroptosis.

This study functionally characterized “primitive” gasdermin (GSDM) variants from bacteria and fungi—bGSDM from Runella zeae and fGSDM/HET-Q1 from Podospora anserina—to understand mechanisms and plasticity of pyroptosis-like pore formation. It showed that these primitive GSDM homologs can form cytotoxic pores, with biochemical properties distinct from the canonical modern protease-activated GSDM pathway. These insights broaden understanding of how pore-forming executioners evolved and how pyroptosis mechanisms can vary across life.

Su Z, Huang M, Gan J et al. · Science advances · (2026) · View on PubMed ↗ · Free PDF ↗

Ligand-tuned extracellular domain dynamics are correlated with signaling states in an adhesion GPCR.

This study used single-molecule FRET (smFRET) and intracellular signaling assays to determine how ligand engagement tunes extracellular domain (ECR) dynamics of the adhesion GPCR ADGRG6 (GPR126) and correlates with signaling states. It revealed that the ADGRG6 ECR transitions among three conformational states and that locking the ECR in the closed conformation traps the receptor and alters signaling output. These findings connect partner-driven ECR conformational dynamics to functional signaling states in an adhesion GPCR, informing how extracellular cues regulate receptor activity.

Cechova K, Bandekar SJ, Kordon SP et al. · Science advances · (2026) · View on PubMed ↗ · Free PDF ↗

Advances in Cyclic Peptides Targeting G Protein-Coupled Receptors.

This review summarized advances in cyclic peptides designed to target peptide-responsive G protein-coupled receptors (GPCRs), focusing on how constrained cyclic topologies engage extended receptor interfaces. It highlights that cyclic peptides can preorganize pharmacophoric elements and tune selectivity and signaling by engaging orthosteric or allosteric contacts that are difficult for conventional small molecules to access. The work is significant for guiding rational design of next-generation peptide therapeutics for GPCRs with peptide-responsive binding modes.

Zhou Y, Li N, Zheng JS · Chembiochem : a European journal of chemical biology · (2026) · View on PubMed ↗

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Clinical oncology evidence synthesis & treatment optimization

Survival Benefit of ARSI Therapy in Japanese mCSPC: A Systematic Review and Meta-Analysis.

This systematic review and meta-analysis evaluated whether adding a second-generation androgen receptor signaling inhibitor (ARSI) to androgen deprivation therapy (ADT) improves overall survival in Japanese patients with metastatic castration-sensitive prostate cancer (mCSPC), comparing ARSI+ADT against conventional hormonal therapy used in Japan (ADT alone or combined androgen blockade). The key finding was that ARSI-based therapy conferred a survival benefit in the Japanese treatment context, indicating that the OS advantage seen in Western ADT-based trials also applies when the comparator is conventional Japanese hormonal regimens. This supports broader clinical adoption of ARSI+ADT for Japanese mCSPC patients and helps reconcile differences in historical standard-of-care between regions.

Iwamoto H, Izumi K, Hori T et al. · International journal of urology : official journal of the Japanese Urological Association · (2026) · View on PubMed ↗

Association between opioid use and treatment discontinuation in patients receiving nivolumab: a real-world database study.

This retrospective real-world database study examined whether baseline opioid use is associated with time to treatment discontinuation (TTD) in patients receiving nivolumab monotherapy for non-small cell lung, gastric, colorectal, or renal cell carcinoma. Using the JMDC database (2015–2020; follow-up through 2022) and multivariable Cox models with propensity score matching and landmark analyses, it evaluated the relationship between pre-index opioid prescriptions and subsequent nivolumab discontinuation risk. The findings are clinically relevant because they may identify opioid use as a prognostic or confounding factor affecting immunotherapy persistence in routine practice.

Uejima K, Takahashi T, Matsui M et al. · Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · (2026) · View on PubMed ↗

Utilization patterns of second-generation androgen receptor pathway inhibitors as first-line therapy for prostate cancer in the United States.

The study analyzed real-world prescribing patterns of second-generation androgen receptor pathway inhibitors (enzalutamide, apalutamide, darolutamide) as first-line therapy for advanced prostate cancer in the United States using the Merative MarketScan database (2012–2023). It found temporal trends and utilization patterns consistent with differences in market entry timing and toxicity profiles influencing which ARPI patients received first-line. This helps clinicians and health systems anticipate how drug characteristics and adoption patterns affect treatment selection in practice.

Weitzner AS, Lokeshwar SD, Cronin C et al. · Prostate cancer and prostatic diseases · (2026) · View on PubMed ↗

Comparative effectiveness of ofatumumab and ocrelizumab in relapsing multiple sclerosis: a target trial emulation using multinational registry data.

This study compared the real-world effectiveness of anti-CD20 therapies ofatumumab versus ocrelizumab in adults with relapsing-remitting multiple sclerosis (RRMS) using a target trial emulation with multinational registry data from MSBase and the Observatoire Français de la Sclérose en Plaques (Jan 2021–Dec 2024). Patients initiating ofatumumab or ocrelizumab were propensity-score matched 1:1, and the primary outcomes were annualised relapse rate (ARR) and time to first relapse. If confirmed in the full results, these findings will inform comparative effectiveness and treatment selection between two widely used anti-CD20 agents in routine RRMS care.

Zhu C, Vukusic S, Kalincik T et al. · Journal of neurology, neurosurgery, and psychiatry · (2026) · View on PubMed ↗

Adjuvant oxaliplatin with S-1 (SOX) versus S-1 for stage II-III gastric cancer (CAPITAL): A randomized, open-label, phase 3 trial.

This randomized phase 3 trial studied adjuvant oxaliplatin plus S-1 (SOX) versus S-1 alone in patients with resected stage II–III gastric or gastroesophageal junction adenocarcinoma after D2 gastrectomy (CAPITAL; NCT01795027). The key finding reported in the abstract is the trial’s comparative efficacy and safety assessment with overall survival as the primary endpoint, with results truncated in the provided text. If SOX improves overall survival over S-1 alone, it would refine standard adjuvant therapy for D2-resected stage II–III gastric/GEJ cancer.

Nie RC, Chen S, Wan J et al. · Med (New York, N.Y.) · (2026) · View on PubMed ↗

Consensus on standardized later-line systemic therapy for hepatocellular carcinoma.

This consensus paper synthesized evidence and expert recommendations to standardize later-line systemic therapy for hepatocellular carcinoma (HCC) after failure of first-line targeted therapy, immune checkpoint inhibitors, or combination regimens. The key output is a structured, evidence-based framework addressing how to assess progression and resistance and how to select subsequent systemic options while accounting for country-level differences in drug access. This is significant for harmonizing real-world clinical decision-making and improving outcomes after first-line treatment failure in HCC.

Yu H, Cheng J, Xia F et al. · Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy · (2026) · View on PubMed ↗

A meta-analysis of cisplatin-based versus carboplatin-based adjuvant chemotherapy for completely resected non-small cell lung cancer.

The study performed a meta-analysis comparing cisplatin-based versus carboplatin-based adjuvant chemotherapy in patients with completely resected non-small cell lung cancer (NSCLC). It searched PubMed and Cochrane CENTRAL up to April 7, 2026 to synthesize survival outcomes from randomized and observational studies, addressing the clinical question of long-term benefit when carboplatin is used for cisplatin-ineligible patients. This is significant for informing adjuvant regimen selection in resected NSCLC by clarifying comparative survival evidence between cisplatin and carboplatin strategies.

Hamaji M, Takeuchi J, Ozu N et al. · General thoracic and cardiovascular surgery · (2026) · View on PubMed ↗

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Hematologic malignancies & leukemia/lymphoma therapy strategies

The SF3b complex in cancer: structural basis, molecular mechanisms, and therapeutic opportunities.

This review analyzed the SF3b (splicing factor 3b) complex in cancer, integrating structural insights from cryo-electron microscopy with genetic and functional evidence for how SF3b dysregulation drives aberrant alternative splicing. It highlights structural plasticity of SF3b (open–closed conformational transitions) that stabilizes pre-mRNA substrates and emphasizes therapeutic opportunities arising from recurrent SF3b core mutations and splicing vulnerabilities. The synthesis supports SF3b as both a mechanistic driver of oncogenic splicing and a potential drug target.

Li S, Shang L, Yang J et al. · Blood advances · (2026) · View on PubMed ↗ · Free PDF ↗

Prognostic value of measuring LSC frequency in AML: a systematic review and meta-analysis.

This systematic review and reconstructed individual patient data meta-analysis evaluated the prognostic value of measuring leukemia stem cell (LSC) frequency at diagnosis and in remission in acute myeloid leukemia (AML). Across studies reporting overall survival and/or event-free survival, LSC measurements were assessed for their ability to improve risk stratification and monitor residual disease, with the detailed effect estimates truncated in the provided text. Clinically, standardized LSC quantification could help predict relapse risk and guide treatment intensity in AML.

Reuvekamp T, Lin M, Ngai LL et al. · Blood advances · (2026) · View on PubMed ↗ · Free PDF ↗

ELTS Score and Early “Warning” Define a Two-Stage Risk Framework for Failure-Free Survival in Chronic-Phase CML.

This pooled analysis studied predictors of failure-free survival (FFS) in chronic-phase chronic myeloid leukemia (CP-CML) in 710 newly diagnosed patients from the JALSG CML212 and New TARGET prospective studies, incorporating the ELN 2025 “Warning” category into FFS event definitions. The key finding is that the ELTS score and an early “warning” two-stage risk framework better characterizes transitions to an unfavorable state and predicts treatment failure in the tyrosine kinase inhibitor (TKI) era. This could improve early risk stratification and guide monitoring or treatment adjustments for CP-CML patients.

Takagi F, Ono T, Takahashi N et al. · Blood advances · (2026) · View on PubMed ↗ · Free PDF ↗

Mosunetuzumab With Response-Adapted Polatuzumab Vedotin and Obinutuzumab in Untreated Indolent B-Cell Non-Hodgkin Lymphoma.

This clinical study evaluated a chemotherapy-free strategy in untreated indolent B-cell non-Hodgkin lymphoma by giving eight cycles of the CD3/CD20 bispecific antibody mosunetuzumab and then using response-adapted polatuzumab vedotin plus obinutuzumab for patients without complete response on PET-CT. The key finding is the reported efficacy of this response-adapted sequencing approach, with the primary endpoint details truncated in the provided abstract. If effective, this regimen could reduce reliance on conventional chemoimmunotherapy while maintaining disease control in follicular lymphoma and marginal zone lymphoma.

Lynch RC, Poh C, Shadman M et al. · Journal of clinical oncology : official journal of the American Society of Clinical Oncology · (2026) · View on PubMed ↗

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Cardiovascular disease therapeutics & risk prediction/AI

EFFICACY OF PERINDOPRIL IN PATIENTS WITH HEART FAILURE AND REDUCED EJECTION FRACTION.

This study evaluated the efficacy of the ACE inhibitor perindopril in patients with heart failure with reduced ejection fraction (HFrEF), comparing outcomes including reverse cardiac remodeling and clinical endpoints against another treatment arm (sa truncated in the abstract). It reports that perindopril’s therapeutic effects were assessed specifically in an HFrEF cohort where robust perindopril-specific data were previously limited. The clinical significance is that it aims to clarify perindopril’s role in HFrEF management and support evidence-based optimization of ACE-inhibitor therapy.

Nazghaidze N, Petriashvili S, Agladze R et al. · Georgian medical news · (2026) · View on PubMed ↗

Artificial intelligence in cardiovascular care: a systematic review and meta-analysis of randomised controlled trials.

This systematic review and meta-analysis synthesized randomized controlled trials evaluating artificial intelligence (AI)-enabled interventions in cardiovascular care and assessed trial design, AI system characteristics, and methodological quality/reporting transparency. The key finding was that evidence from RCTs remains heterogeneous and that methodological quality and reporting transparency vary across studies, limiting certainty about real-world effectiveness. Scientifically, it identifies gaps in how AI interventions are tested and reported, guiding more rigorous future cardiovascular AI trials.

Ong AQC, Ang CS, Bojic I et al. · EClinicalMedicine · (2026) · View on PubMed ↗ · Free PDF ↗

SGLT2 inhibition improves sarcomere contractile dysfunction in human models of dilated cardiomyopathy.

This study tested the sodium-glucose cotransporter 2 inhibitor empagliflozin (EMP) in patient-specific human models of dilated cardiomyopathy (DCM) to determine whether SGLT2 inhibition improves cardiomyocyte sarcomere contractile dysfunction. EMP improved sarcomere contractile performance in these human DCM models, indicating a beneficial effect on contractile machinery. These results provide mechanistic support for SGLT2 inhibitor therapy in heart failure and motivate further work to define the molecular pathways linking SGLT2 inhibition to sarcomere function.

Plota D, Saleem HN, Lin KH et al. · Journal of translational medicine · (2026) · View on PubMed ↗ · Free PDF ↗

Development and External Validation of an Echocardiography-Based AI Model for Predicting Aortic Stenosis Progression.

This study developed and externally validated an echocardiography-based AI model to predict fixed-horizon progression of aortic stenosis (AS) from mild/moderate to severe using structured echocardiographic report data from two tertiary centers. The key finding is the model’s performance in externally validating prediction of AS progression, with the specific metrics truncated in the provided abstract. If robust, this approach could enable more individualized surveillance intervals and earlier intervention for patients with rapid AS progression.

Itelman E, Faierstein K, Caller T et al. · JACC. Advances · (2026) · View on PubMed ↗ · Free PDF ↗

HSP27 regulates force-coordinated DDR1 condensate disassembly and liquid-to-gel phase transition.

This study investigated endothelial cell mechanosensing by examining how heat shock protein 27 (HSP27) regulates DDR1 (discoidin domain receptor 1) condensate disassembly and liquid-to-gel phase transition under different shear stresses. It found that laminar shear induces rapid, transient DDR1 condensation, whereas atherogenic shear causes delayed, sustained condensation linked to YAP activation, and that HSP27 controls the DDR1 condensate dynamics. Mechanistically, the work identifies HSP27 as a regulator of shear-dependent DDR1 phase behavior, offering a potential target to modulate atherosclerosis-relevant signaling.

Zhao D, Liu J, Liu Y et al. · Science advances · (2026) · View on PubMed ↗ · Free PDF ↗

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Pulmonary disease & multi-organ risk (COPD/ILD/NSCLC)

Chronic obstructive pulmonary disease and risk of incident cardiovascular disease, chronic kidney disease, and death: a systematic review and meta-analysis.

This systematic review and meta-analysis quantified the association between chronic obstructive pulmonary disease (COPD) and incident cardiovascular disease, incident chronic kidney disease, and death using case-control evidence. The key finding was that COPD was associated with higher risks of these adverse outcomes, with pooled estimates supporting COPD as a multi-organ risk marker rather than only a lung disease. Clinically, this strengthens the rationale for cardiovascular and renal risk screening and prevention strategies in patients with COPD.

Joseph T, Gao C, Nadarajah R et al. · EClinicalMedicine · (2026) · View on PubMed ↗ · Free PDF ↗

CT-Based Biomarkers for Predicting Progressive Phenotypes in Interstitial Lung Diseases: A Retrospective Cohort Study.

This retrospective two-centre cohort study evaluated whether CT-based Single Time Point Prediction (STP) scores outperform other quantitative CT fibrosis/ground-glass measures for predicting progressive phenotypes in interstitial lung diseases (ILD) excluding idiopathic pulmonary fibrosis (IPF). Using an automated quantification system to derive quantitative lung fibrosis (QLF), quantitative ground-glass opacity (QGG), and quantitative ILD (QILD), the key finding was the relative predictive performance of STP versus alternative quantitative CT scores for subsequent disease progression. Scientifically and clinically, this supports more accurate baseline CT risk stratification to identify patients likely to develop progressive ILD.

Oh JH, Song JW, Goldin J et al. · Respirology (Carlton, Vic.) · (2026) · View on PubMed ↗ · Free PDF ↗

Prognostic Significance of Spread Through Airspaces (STAS) in Stage Ia/bN0 Non-small Cell Lung Cancer - An Evaluation in the JCOG0802/WJOG4607L Clinical Trial Patients.

This study evaluated the prognostic impact of tumor spread through air spaces (STAS) and histologic tumor grade in stage pT1a/bN0 non-small cell lung cancer patients from the JCOG0802/WJOG4607L trial, comparing segmentectomy versus lobectomy. Across 593 tumors assessed by 32 expert pulmonary pathologists, STAS and tumor grade were associated with worse relapse-free survival and overall survival, with the effect assessed specifically in the context of surgical extent. These findings support incorporating STAS into risk stratification when choosing between segmentectomy and lobectomy for early-stage NSCLC.

Yatabe Y, Beasley MB, Borczuk A et al. · Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer · (2026) · View on PubMed ↗

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Diabetes, obesity & endocrine-metabolic complications

The liver in diabetes: current state and future perspectives.

This review studied the relationship between diabetes mellitus and liver disease, focusing on metabolic dysfunction-associated steatotic liver disease (MASLD) and its fibrosis risk in people with type 2 diabetes. It highlights that MASLD is common yet frequently undiagnosed (up to 95% undiagnosed) due to lack of accepted steatosis assessment recommendations and discusses emerging diagnostic and management strategies, including limitations of non-invasive tests that may overestimate progression. The article is clinically significant because it frames MASLD as a major diabetes-related complication and outlines future directions for improving detection and treatment of steatosis and fibrosis.

Yki-Järvinen H, Roden M · Diabetologia · (2026) · View on PubMed ↗

ASSESSING THE EFFECTIVENESS OF LIFESTYLE CLINIC INTERVENTIONS ON CARDIOMETABOLIC RISK FACTORS: A RETROSPECTIVE STUDY.

This retrospective cohort study assessed the effectiveness of lifestyle clinic interventions on cardiometabolic risk factors among adult patients in Saudi Arabia over six months. Using real-world data from 281 participants enrolled at the Lifestyle Clinic of King Abdulaziz Medical City, Jeddah, it compared changes/associations in metabolic risk factors between participants categorized into metabolic and smoking-related groups (with the abstract truncated). The significance is that it provides practical, local evidence on whether structured lifestyle clinic participation improves cardiometabolic risk profiles in routine clinical care.

Althumali Z, Khouja J, Alnemari R et al. · Georgian medical news · (2026) · View on PubMed ↗

Effect of tirzepatide and semaglutide on blood pressure: A systematic review and meta-analysis.

This systematic review and meta-analysis evaluated treatment-emergent adverse events related to blood pressure—specifically hypertension and hypotension—in people with type 2 diabetes mellitus (T2DM) or obesity receiving tirzepatide or semaglutide. The authors pooled risk ratios from randomized trial data to quantify the relative risk of these blood pressure TEAEs for each drug. Clinically, the results aim to clarify cardiovascular safety profiles of GLP-1/GIP-based therapies and inform risk monitoring when using tirzepatide versus semaglutide.

Chen QX, Zhou XY, Wu Q et al. · Endocrine · (2026) · View on PubMed ↗

Machine Learning-Derived Sarcopenia Signature Identifies High-Risk Molecular State in T2D Skeletal Muscle.

The study developed and validated a machine-learning-derived sarcopenia transcriptomic signature in type 2 diabetes (T2D) skeletal muscle using bulk RNA-seq cohorts (GSE111016, GSE226151, and GSE111010), a nine-donor single-nucleus RNA-seq dataset, and physical performance data (GSE144304). The frozen signature projected onto T2D cohorts and was associated with lower-extremity physical performance, achieving AUCs of 0.906 in training and 0.762 in validation. This provides a gene-expression-based tool to identify high-risk molecular sarcopenia states in T2D muscle and supports stratification for interventions.

Zhao Q, He Q, Wang S et al. · Cell biochemistry and biophysics · (2026) · View on PubMed ↗

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Geriatrics, frailty, and cognitive aging/dementia risk

Early Comprehensive Geriatric Assessment in Acute Care: Evidence and Implementation.

This article studied the evidence base and implementation considerations for performing an Early Comprehensive Geriatric Assessment (CGA) in older adults admitted to acute care settings. It reports that frail older patients have higher risks of delirium, functional decline, prolonged hospitalization, and mortality, and that CGA is often introduced only after admission rather than at the earliest opportunity. Earlier frailty recognition through timely CGA is presented as clinically significant for more individualized decision-making and better alignment of care with patient needs.

Ducker E · Cureus · (2026) · View on PubMed ↗

A long short-term memory network with SHAP interpretability for dynamic prediction of ICU delirium: development and external validation.

This retrospective cohort study developed and externally validated a long short-term memory (LSTM) neural network with SHAP interpretability to dynamically predict ICU delirium using baseline and rolling 24-hour observation-window variables. The key finding was that the model achieved predictive performance in an internal cohort of 464 ICU patients and maintained generalizability in an external test set of 70 patients, while SHAP provided interpretable contributions of dynamic features across time windows. This is clinically significant because it offers a more actionable, time-updated and explainable delirium risk tool for ICU decision-making.

Lei L, Xia H, Zhang R et al. · Frontiers in digital health · (2026) · View on PubMed ↗ · Free PDF ↗

From Common Pathway to Divergent Diseases: Metabolic Aspects of Inborn Errors of CoA Biosynthesis.

This review synthesized how biallelic variants in coenzyme A (CoA) biosynthesis genes PANK2, PPCS, PPCDC, and COASY produce distinct inborn errors of CoA biosynthesis with divergent clinical phenotypes. It reports that PANK2 and COASY defects mainly cause neurological disease within the neurodegeneration with brain iron accumulation (NBIA) spectrum, whereas PPCS and PPCDC deficiencies predominantly present as severe early-onset dilated cardiomyopathy, with COASY also linked to pontocerebellar hypoplasia and riboflavin-responsive lipid storage. Clinically, the gene–phenotype mapping can guide diagnosis and targeted management, and scientifically it clarifies how a conserved metabolic pathway yields tissue-specific disease outcomes.

Di Meo I, Anikster Y, Tiranti V et al. · Journal of inherited metabolic disease · (2026) · View on PubMed ↗ · Free PDF ↗

Histological aging signatures for monitoring tissue-specific aging and disease.

This study developed deep-learning “tissue clocks” from 25,712 whole-slide histopathology images spanning 40 tissue types across 983 individuals in the Genotype-Tissue Expression cohort. The resulting histological aging signatures predicted biological age and correlated with established aging markers such as telomere attrition, subclinical pathologies, and comorbidities. These tissue-specific clocks could enable improved monitoring of aging-related disease risk and progression using routine pathology data.

Abila E, Buljan I, Zheng Y et al. · Nature medicine · (2026) · View on PubMed ↗ · Free PDF ↗

Frailty transitions, depressive symptoms, and incident dementia: findings from four longitudinal studies.

This analysis used four longitudinal cohorts (Health and Retirement Study, China Health and Retirement Longitudinal Study, SHARE, and ELSA) to test whether frailty transitions and depressive symptoms predict incident dementia in adults aged ≥50. In 59,331 participants, frailty reversal and frailty transitions were associated with dementia risk, and depressive symptoms were evaluated as a potential mediator of this pathway. The results strengthen the case that targeting frailty (and related mood symptoms) could reduce dementia incidence across diverse aging populations.

Fang J, Cheng W, Li H et al. · Journal of affective disorders · (2026) · View on PubMed ↗

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Women’s health & reproductive aging/PCOS

Physical activity delays ovarian aging in part through adiponectin-related signaling pathways.

The study assessed whether physical activity delays ovarian aging and explored mechanisms involving adiponectin-related signaling using cross-sectional human analyses (UK Biobank n=152,435; NHANES n=12,418) plus mouse animal experiments. It found that lower physical activity was associated with postmenopausal status compared with premenopausal status, and that higher activity in mice delayed ovarian aging in part through adiponectin-related signaling pathways. This supports lifestyle-based modulation of adiponectin signaling as a mechanistic route to preserve ovarian function.

Li B, Zheng N, Luo T et al. · Nature aging · (2026) · View on PubMed ↗

Integrative Multi-omics Analysis for Prioritization of Candidate Genes in Polycystic Ovary Syndrome.

This study used cross-tissue transcriptome-wide association studies (TWAS) integrating FinnGen R12 GWAS with GTEx v8 eQTL data to prioritize candidate effector genes for polycystic ovary syndrome (PCOS) and then validated hits in independent PCOS meta-analyses (Rotterdam- and NIH-criteria cohorts) and UK Biobank. The authors prioritized high-confidence PCOS candidate genes by leveraging GWAS-to-expression links across tissues and confirming consistency in external summary-statistics datasets. These integrative multi-omics results provide a prioritized gene list and mechanistic leads for targeted PCOS therapeutic development.

Guo R, Liao D, Huang J et al. · FASEB journal : official publication of the Federation of American Societies for Experimental Biology · (2026) · View on PubMed ↗

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Infectious disease mechanisms & host-directed antivirals

TOLLIP suppresses picornavirus internalization by targeting and degrading VP1 protein through selective autophagy.

This study investigated how the host restriction factor TOLLIP regulates foot-and-mouth disease virus (FMDV) infection by targeting the viral capsid protein VP1, using the DNAJA3–autophagy pathway in the context of selective autophagy. The authors found that DNAJA3 recruits TOLLIP, enabling direct interaction with VP1 (via VP1 residues 1–37) and promoting selective autophagic degradation of VP1 to suppress viral internalization. These findings identify a specific host–viral protein axis (DNAJA3–TOLLIP–VP1) that could be exploited to develop host-directed antiviral strategies against picornaviruses like FMDV.

Zhang W, Yang Y, Shao W et al. · Autophagy · (2026) · View on PubMed ↗

Fungal extracellular vesicles as biomarkers in candidiasis: biogenesis, virulence, and CNS diagnostic applications.

This review evaluated fungal extracellular vesicles (EVs) in candidiasis as both mechanistic contributors to virulence and potential biomarkers for CNS diagnostic applications. The key finding was that EVs can carry protected virulence factors (including candidalysin and Als3) and that profiling circulating fungal EVs could enable faster, more sensitive diagnostics than blood culture. Scientifically, it supports EV-based biomarker development for invasive candidiasis, including potential translation to CNS infection detection.

Choi J, Wang X, Moon J et al. · Frontiers in cell and developmental biology · (2026) · View on PubMed ↗ · Free PDF ↗

Potent type-specific de novo antibodies complement broadly reactive imprinted antibodies in immune responses to SARS-CoV-2 variants.

The study examined how de novo SARS-CoV-2 variant–specific neutralizing monoclonal antibodies are generated in ancestral-imprinted humans after sequential exposures to viral variants. It found that potent type-specific de novo antibodies can complement broadly reactive imprinted antibodies during immune responses to SARS-CoV-2 variants, with de novo antibodies using distinct V(D)J gene usage patterns. This clarifies how immune imprinting shapes variant immunity and informs vaccine/booster strategies aimed at eliciting effective de novo, variant-matched antibody responses.

Johnston TS, Li SH, Painter MM et al. · Nature immunology · (2026) · 1 citations · View on PubMed ↗ · Free PDF ↗

Parasitophorous vacuole membranes of Toxoplasma gondii and Plasmodium falciparum lack the lipid asymmetry characteristic of host cell plasma membranes.

This biochemical cell-biology study examined the lipid organization of the parasitophorous vacuole membrane (PVM) in Toxoplasma gondii and Plasmodium falciparum. Using quick-freeze, freeze-fracture replica labeling (QF-FRL), the authors found that the PVM lacks the lipid transbilayer asymmetry characteristic of host cell plasma membranes. This mechanistic insight clarifies how apicomplexan parasites maintain a distinct membrane barrier for nutrient uptake and immune evasion.

Konishi R, Nakashima Y, Masatani T et al. · Biochimica et biophysica acta. Biomembranes · (2026) · View on PubMed ↗

Strong, sustained type I IFN signaling acts cell intrinsically to impair IFNγ responses and cause tuberculosis susceptibility.

This study examined how type I interferon signaling affects immunity to Mycobacterium tuberculosis (Mtb) at the cellular level. The authors showed that strong, sustained type I IFN signaling impairs IFNγ responses cell intrinsically in a subset of infected macrophages with high type I IFN activity, and that genetic elimination of RESIST (via stabilization of transcript) altered this susceptibility phenotype. These findings identify a specific IFN signaling state that drives TB susceptibility and suggest targets for modulating harmful type I IFN effects during infection.

Fattinger SA, Parisi B, Chavez RA et al. · Cell host & microbe · (2026) · View on PubMed ↗

Stress granules formed during infections with RNA viruses have significant virus-specific differences in generation and composition.

This study examined how stress granules (SGs) are generated and composed during infections with different RNA viruses, focusing on virus-specific differences in SG formation. It found that SG biogenesis and molecular composition vary substantially depending on the infecting RNA virus. These results clarify how distinct viruses differentially manipulate the host translational stress response, informing antiviral strategies targeting SG pathways.

Lang RM, Steiner S, Kelly J et al. · PLoS biology · (2026) · View on PubMed ↗

Distinct transcriptional logics of catechol siderophore transporters in Pseudomonas aeruginosa for efficient iron acquisition.

The study investigated how catechol siderophore transporters in Pseudomonas aeruginosa (including PfeA, FvbA, PirA, and PiuA) are transcriptionally regulated by specific siderophores using fluorescent reporters and mathematical modeling. It found distinct “transcriptional logics,” with pfeA and fvbA showing switch-like induction by enterobactin and vibriobactin at ~100 nM, reflecting environment-dependent iron acquisition strategies. This clarifies the regulatory rules governing siderophore-mediated iron uptake and can inform strategies to disrupt iron acquisition in P. aeruginosa.

Volck F, Revillot-Schmidt AE, Hubert T et al. · Proceedings of the National Academy of Sciences of the United States of America · (2026) · View on PubMed ↗ · Free PDF ↗

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Microbiome & synthetic microbial therapeutics

Synthetic microbial communities: emerging live biotherapeutics for targeted gut microbiome modulation.

This review summarized the emerging field of synthetic microbial communities (SynComs) as defined live biotherapeutics for targeted gut microbiome modulation. It compared “top-down” versus “bottom-up” SynCom construction strategies and described how SynComs can restore intestinal homeostasis through mechanisms such as targeted antagonism and microbiome functional modulation, while addressing biosafety and composition control limitations of fecal microbiota transplantation (FMT). Scientifically, it positions SynComs as a more controllable and safer alternative to donor-derived preparations for precision microbiome therapies.

Zhang R, Li H, Wang C et al. · Gut microbes · (2026) · View on PubMed ↗ · Free PDF ↗

Gut microbiota and gut-kidney axis in kidney diseases: therapeutic potential and perspectives of natural products.

This narrative-style review discussed the gut microbiota–gut-kidney axis in kidney diseases, focusing on how gut dysbiosis in chronic kidney disease (CKD) alters uremic toxin production (e.g., indoxyl sulfate, p-cresyl sulfate, TMAO) and reduces protective metabolites such as short-chain fatty acids (SCFAs) and indole-3-aldehyde. The key finding was that these microbiome-driven metabolite shifts contribute to CKD progression and systemic immune/metabolic imbalance, creating therapeutic opportunities via natural products that can restore microbial function or metabolite profiles. This is significant because it frames microbiome-targeted natural product therapies as plausible adjuncts for CKD management.

Wang Q, Zhang J, Chen R et al. · Frontiers in pharmacology · (2026) · View on PubMed ↗ · Free PDF ↗

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Autoimmune/inflammatory disease management & diagnostics

Digital screen exposure and migraine burden: a systematic review and meta-analysis.

This systematic review and meta-analysis studied the association between digital screen exposure and migraine/headache burden across pediatric, adolescent, and adult populations, and summarized proposed neurobiological mechanisms. It found and synthesized evidence linking screen exposure with migraine/headache outcomes such as attack frequency, severity, disability, and related secondary measures. The findings are significant because they support screen-use risk considerations and help motivate mechanistic research and potential behavioral interventions for migraine management.

Gowda N, Harish S, Tej G · Journal of neurology · (2026) · View on PubMed ↗

Multiple paths to health: A scoping review of dietary interventions for adults with Crohn’s disease and ulcerative colitis.

This scoping review mapped how dietary interventions are defined, composed, and evaluated for adults with Crohn’s disease (CD) and ulcerative colitis (UC) across studies published from 2000–2025. The key finding was that there are multiple “paths” to dietary intervention evidence with substantial variation in intervention types, definitions, and outcome measures used to assess symptoms, remission, or disease activity. This is significant for designing future dietary trials in IBD by standardizing how interventions and endpoints are conceptualized and reported.

Ingridsdotter J, Vejzovic V, Elmerstig E et al. · Therapeutic advances in gastroenterology · (2026) · View on PubMed ↗ · Free PDF ↗

Neuroinflammation, HPA Axis Dysregulation, Cytokine Activity and Nutritional Modulation in Depression: A PRISMA-compliant Systematic Review.

This PRISMA-compliant systematic review synthesized evidence linking depression to neuroinflammation, hypothalamic-pituitary-adrenal (HPA) axis dysregulation, cytokine activity, and related biological pathways, with attention to nutritional modulation. The key finding was that dysregulated cytokine signaling and HPA-axis function, alongside oxidative stress and mitochondrial dysfunction and gut-brain mechanisms, are repeatedly implicated across studies, suggesting nutrition could modulate these interconnected pathways. Clinically and scientifically, it supports nutritional strategies as potential adjunctive targets while highlighting the need for better mechanistic and interventional evidence.

Ts S, Yücel Ş, Gupta SK et al. · Annals of neurosciences · (2026) · View on PubMed ↗ · Free PDF ↗

Characteristics of Real-World Patients with Psoriasis Receiving Guselkumab or Interleukin-17 Inhibitors: Data from the Psoriasis Longitudinal Assessment and Registry (PSOLAR).

This registry-based real-world study described baseline characteristics of psoriasis patients enrolled in the Psoriasis Longitudinal Assessment and Registry (PSOLAR) after protocol amendment (March 26, 2018) that specifically included patients receiving guselkumab or an interleukin-17 inhibitor (IL-17i). The key finding was that, as of July 12, 2025, 3501 patients were included with substantial representation of both treatment groups (guselkumab n=2213; IL-17i n=1288), enabling comparative characterization of these biologic-treated populations. Clinically, this provides foundational context for interpreting safety and outcomes analyses in real-world guselkumab versus IL-17i use in psoriasis.

Strober B, Augustin M, Tada Y et al. · Journal of psoriasis and psoriatic arthritis · (2026) · View on PubMed ↗ · Free PDF ↗

Exploratory multi-omics analysis suggests context-dependent immune responses to vitamin D3 supplementation in PBMCs of multiple sclerosis patients.

This study used longitudinal RNA-seq and ATAC-seq on peripheral blood mononuclear cells (PBMCs) from relapsing-remitting multiple sclerosis (RRMS) patients starting daily high-dose vitamin D3 supplementation versus continuing regular supplementation, and compared them with healthy individuals receiving monthly vitamin D3 bolus. Multi-omics profiling suggested that vitamin D3 induces context-dependent immune regulatory programs, with immune response patterns differing by disease status and supplementation regimen. These findings support a mechanistic, patient-context-specific model for how vitamin D3 may modulate immune pathways relevant to MS risk and progression.

Tripathi T, Gospodarska E, Geran R et al. · Frontiers in immunology · (2026) · View on PubMed ↗ · Free PDF ↗

Effects of acupuncture on brain function in patients with depression: A meta-analysis of functional magnetic resonance imaging studies.

This coordinate-based meta-analysis evaluated resting-state fMRI neuroplasticity effects of acupuncture in patients with major depressive disorder across 7 randomized controlled trials, using regional homogeneity and amplitude of low-frequency fluctuations (ALFF/fALFF) metrics. The pooled results identified consistent brain activity/connectivity alterations associated with acupuncture-induced changes in depressed patients. These findings support acupuncture as a potentially effective adjunctive therapy and provide candidate neural targets for future mechanistic and clinical studies.

Zhang J, Shi X, Wang W et al. · Medicine · (2026) · View on PubMed ↗ · Free PDF ↗

Peyer’s patch M cells organize an epithelial niche that sustains group 3 innate lymphoid cells and IL-22.

This study investigated how Peyer’s patch microfold (M) cells organize an epithelial niche that supports group 3 innate lymphoid cells (ILC3s) and IL-22 production. It found that M cells establish a spatial epithelial–ILC3 axis in the dome epithelium that drives ILC3 localization, proliferation, and IL-22, and that epithelial SPI-B (but not hematopoietic SPI-B) is required for this niche to support intestinal IgA responses. Mechanistically, single-cell profiling showed M cells are heterogeneous with tissue- and pathogen-specific transcriptional programs, linking niche organization to mucosal immune function.

Cao WHJ, You Y, Wang N et al. · Nature immunology · (2026) · View on PubMed ↗ · Free PDF ↗

Fiber supplementation in irritable bowel syndrome: a systematic review and meta-analysis of randomized controlled trials.

This systematic review and meta-analysis synthesized randomized controlled trials of fiber supplementation for irritable bowel syndrome (IBS) in adults, comparing fiber supplements versus placebo controls. The key finding is the pooled estimate of clinical response efficacy across trials using risk ratios and 95% confidence intervals based on searches through 9 April 2026. Clinically, it updates the evidence base for whether fiber supplements improve IBS symptoms and supports or refines guideline recommendations.

Staudacher HM, Rucco V, Mancell S et al. · Gastroenterology · (2026) · View on PubMed ↗ · Free PDF ↗

Defining age-related thresholds in hand, wrist, and foot ultrasound: an international, cross-sectional, observational study by the Outcome Measures in Rheumatology Ultrasound Working Group.

This international multicentre cross-sectional observational study defined age-related ultrasound thresholds for three abnormalities (synovial hypertrophy, Doppler signal, and synovial effusion) in healthy adults aged 18–80. In healthy participants recruited from 20 centres across 13 European countries, the authors systematically graded ultrasound findings across hand, wrist, and foot joints to establish how “normal” changes with age. The resulting thresholds improve interpretation of rheumatology ultrasound by reducing age-related misclassification of inflammatory disease.

Sahbudin I, Trickey J, Gouze H et al. · The Lancet. Rheumatology · (2026) · View on PubMed ↗

Distinct postnatal trajectories of mouse dendritic epidermal T cells and Langerhans cells independent of microbiota.

This study mapped postnatal development of mouse epidermal immune populations—dendritic epidermal T cells (DETCs) and Langerhans cells (LCs)—using combined immunophenotyping and single-cell transcriptomics from late embryogenesis through adulthood, testing whether trajectories depend on microbiota. It found distinct differentiation trajectories for DETCs and LCs that proceed independently of microbiota. The results refine models of tissue-resident immune maturation and support microbiota-independent programming of epidermal immune lineages.

Obwegs D, Oschwald A, Koetter LM et al. · Science advances · (2026) · View on PubMed ↗ · Free PDF ↗

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Renal disease & kidney injury/endpoints

Hallmarks of acute kidney injury: molecular endotypes, precision phenotyping, and phase-adapted therapy.

This article studied acute kidney injury (AKI) by organizing its heterogeneity into molecular endotypes and proposing precision phenotyping and phase-adapted therapy strategies. It identifies four interconnected pathophysiologic dimensions—initiation/effector injury, cell fate/immune microenvironment, repair/outcome determination, and systemic integration—and links them to measurable biomarkers, imaging, and functional tests. The significance lies in providing a structured, biomarker-driven framework to better stratify AKI biology and guide more tailored, time-sensitive therapeutic approaches.

Hu H, Liu Z, Ji R et al. · EBioMedicine · (2026) · View on PubMed ↗

EBV-Driven ODC1 Upregulation Enhances Polyamine Anabolism to Promote Viral Replication and Cisplatin Resistance in Nasopharyngeal Carcinoma.

This study examined how Epstein-Barr virus (EBV) drives polyamine metabolic reprogramming in nasopharyngeal carcinoma (NPC) cells, focusing on the EBV protein BZLF1 and the host rate-limiting enzyme ODC1. Metabolomic and metabolic flux analyses showed EBV upregulates ODC1 transcriptionally via direct BZLF1 promoter binding, enhancing the ODC1–spermidine axis to promote viral replication and cisplatin resistance. These findings identify an EBV–BZLF1→ODC1 polyamine pathway as a mechanistic driver of chemoresistance and a potential metabolic target to improve cisplatin efficacy in EBV-associated NPC.

Li Y, Hu X, Yang C et al. · Advanced science (Weinheim, Baden-Wurttemberg, Germany) · (2026) · View on PubMed ↗

Disease characteristics of SEPSECS deficiency: an international, retrospective, multicenter cohort study.

This international retrospective multicenter cohort study characterized the clinical spectrum of SEPSECS deficiency in 27 individuals with biallelic SEPSECS variants. Using biochemical correlation with neurological symptoms, focused metabolomics, and structural/in vitro activity analyses, the authors proposed three clinical courses—severe early-onset with cerebellar/cerebral atrophy, milder early-onset with gradual deterioration, and late-onset mild disease—highlighting predominant brain involvement. These findings improve genotype–phenotype understanding and diagnostic interpretation for SEPSECS-related selenoprotein biosynthesis disorders.

Killam BY, Knol MJ, Fradejas-Villar N et al. · Genetics in medicine : official journal of the American College of Medical Genetics · (2026) · View on PubMed ↗

maA dual-target modulator of STK11 and PP2Acα from the flowers of Chrysanthemum indicum mitigates drug-induced liver injury.

This preclinical study investigated a dual-target modulator, maA, from Chrysanthemum indicum against drug-induced liver injury (DILI) and its biphasic (hormetic) mechanism. Using compound identification by HRESIMS plus 1D/2D NMR and ECD, and mechanistic testing including mitochondrial transplantation in vitro and in vivo, maA was reported to mitigate DILI via a hormesis-like regulatory pathway. These findings support maA as a candidate natural-product therapeutic strategy for DILI with dose-dependent effects.

Zhou F, Liu Y, Zhao H et al. · Journal of advanced research · (2026) · View on PubMed ↗ · Free PDF ↗

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Perinatal health & pregnancy risk prediction

Machine learning to predict adverse perinatal outcomes: a systematic review and meta-analysis.

This systematic review and meta-analysis evaluated machine learning (ML) models that predict adverse perinatal outcomes (including preterm birth and small for gestational age) using routine clinical data, and compared their performance and risk of bias against logistic regression. Across studies published from 2015–2026, the review synthesized evidence on ML model accuracy and calibration relative to conventional regression approaches while assessing methodological limitations and bias. The work is significant for guiding the development and clinical translation of ML-based perinatal risk prediction tools with attention to validity and bias.

Zhang J, Daniel N, Tiranti A et al. · EClinicalMedicine · (2026) · View on PubMed ↗

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Clinical trial design, consensus, and implementation science

Longitudinal progression, metrics, age-dependence, and modifiers of ataxia severity in SCA27B: a multicentre study of 219 patients.

This multicentre observational study investigated longitudinal progression, age-dependence, and clinical modifiers of ataxia severity in spinocerebellar ataxia 27B (SCA27B) in 219 patients. Using item-level distribution-based analyses of repeated Scale for the Assessment and Rating of Ataxia (SARA) assessments, it characterized how SARA metrics change over time relative to aging-related impairment in healthy controls. The findings are significant for improving precision phenotyping and informing outcome measures and trial planning for this FGF14 GAA repeat-expansion–driven, likely treatable disorder.

Traschütz A, Hilgers RD, Erdlenbruch F et al. · EBioMedicine · (2026) · View on PubMed ↗

Navigating Asparaginase Treatment for Patients With Acute Lymphoblastic Leukemia: US Consensus Panel Recommendations on the Role of Multidisciplinary Care.

The study produced US consensus panel recommendations on multidisciplinary care to improve safe, timely, and complete delivery of asparaginase-based therapy for acute lymphoblastic leukemia/lymphoblastic lymphoma (ALL/LBL). It highlighted operational and clinical barriers—such as complex administration, distinct toxicity, prolonged treatment duration, and variability in institutional infrastructure and supportive services—that can impede asparaginase delivery. This provides actionable guidance for care teams to reduce treatment delays and improve outcomes in patients receiving asparaginase.

Ali A, Elsey G, Fulginiti K et al. · American journal of hematology · (2026) · View on PubMed ↗

REenergizeME: intermittent hypoxia-hyperoxia treatment for myalgic encephalomyelitis/chronic fatigue syndrome-protocol for a randomised, placebo-controlled trial.

This article describes the REenergizeME protocol for a randomized, placebo-controlled trial of intermittent hypoxia-hyperoxia treatment (IHHT) in adults with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). The key scientific premise is that IHHT will induce adaptive physiological and cellular responses relevant to ME/CFS immune-metabolic dysregulation, impaired energy metabolism, vascular dysfunction, and altered oxygen handling. Clinically, the trial is designed to test whether IHHT can serve as a disease-modifying, non-pharmacological intervention for ME/CFS.

Nochi M, Kristensen SK, Mehrani N et al. · BMJ open · (2026) · View on PubMed ↗ · Free PDF ↗

Banff Liver Allograft Pathology Group: late rejection activity is insufficiently represented in the current diagnostic framework - rationale and goals for revision.

This article is a rationale-and-goals proposal from the Banff Liver Allograft Pathology Group addressing how late liver allograft rejection is not adequately captured by the current Banff diagnostic framework. It highlights that late rejection is often clinically silent and differs histologically from classic early acute T cell–mediated rejection (TCMR), with more interface/perivenular inflammation, lymphocyte-predominant infiltrates, and fibrosis. Revising Banff criteria to better represent late rejection activity could improve diagnostic consistency and patient management after liver transplantation.

Bellamy C, Mescoli C, Asadi K et al. · American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · (2026) · View on PubMed ↗ · Free PDF ↗

Neurological effects of encapsulated dexamethasone sodium phosphate in children aged 6-9 years with ataxia telangiectasia (NEAT): a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial.

This multicentre randomized double-blind placebo-controlled phase 3 trial tested erythrocyte encapsulated dexamethasone sodium phosphate (eDSP) for neurological outcomes in children aged 6–9 years with ataxia telangiectasia. The study was designed to evaluate whether eDSP improves safety and efficacy compared with placebo in a population with progressive cerebellar neurodegeneration and no approved therapy. If effective, eDSP would provide evidence for a corticosteroid-based disease-modifying approach in pediatric ataxia telangiectasia.

Russo S, Zielen S, Pietrucha B et al. · The Lancet. Child & adolescent health · (2026) · View on PubMed ↗

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Medical device/biomaterials & engineering (including imaging tech)

Electronic Chip-Mimetic Medical Implants for Controllable Sonothermal Treatments.

This study developed and tested an implantable “electronic chip-mimetic” sonothermal platform using metal–semiconductor heterogeneous interfaces on pretreated titanium (pTi) surfaces. Under ultrasound irradiation, semiconductor coatings (TiO2, SiO2, ZnO, and Te) produced distinct in situ temperature rises (ΔT > 18°C over 15 minutes) whereas conductor coatings did not. The results support a materials/engineering approach for controllable, sterilizable implantable devices that can generate localized therapeutic heat for sonothermal treatments.

Zhang Z, Liu P, Lei J et al. · Advanced science (Weinheim, Baden-Wurttemberg, Germany) · (2026) · View on PubMed ↗

Acbd7 is essential for preserving hair cell-mediated auditory and vestibular function.

The study identified and characterized acyl-CoA binding domain-containing 7 (Acbd7) in mouse inner ear hair cells using single-cell transcriptomics of cochlear organoids and functional analyses in Acbd7-deficient mice. It found that Acbd7 is hair cell–enriched across auditory and vestibular hair cells and that Acbd7 loss causes hair cell degeneration with synaptic defects and reduced calcium currents in inner hair cells. This establishes Acbd7 as an essential sensory-maintenance gene and a potential molecular entry point for therapies for auditory-vestibular disorders.

Wu M, Jia G, Jia Y et al. · Experimental & molecular medicine · (2026) · View on PubMed ↗ · Free PDF ↗

Comparative evaluation of precision, morphology, and structural stability in AI-based dental crown design software programs.

The study compared AI-based dental crown design software with conventional CAD software by evaluating precision, morphology, and structural stability of crowns designed for a maxillary first molar digital cast. It found differences among the AI-based programs and the conventional baseline (3Shape Dental Designer), with performance assessed using quantitative measures of fit/precision and structural stability (details truncated in the abstract). This informs evidence-based selection and validation of AI CAD tools for restorative dentistry.

Sim JH, Noh MJ, Kim HR et al. · The Journal of prosthetic dentistry · (2026) · View on PubMed ↗

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Generated automatically on August 17, 2026 from PubMed’s trending articles. Summaries are AI-generated; always consult the original publication for clinical or research decisions.