PubMed Trending Research Digest — September 05, 2026

Automated digest · 96 articles · 14 research areas · September 05, 2026

Overview

Across this week’s set, a dominant theme is the push toward more human-relevant, mechanism-informed biomarkers and endpoints—spanning regulatory science (NAMs), longitudinal clinical monitoring (perioperative hemoglobin trajectories), and patient-anchored interpretation of trial endpoint changes in heart failure. Several studies also emphasize noninvasive or minimally invasive readouts for risk and response: liquid biopsy (ctDNA/CTCs) for metastatic breast cancer, CSF amyloid measures for cerebral amyloid angiopathy severity, and imaging/biomarker frameworks such as spatial habitat radiomics for tertiary lymphoid structures. Together, these works reflect a broader shift from single time-point measures toward dynamic, longitudinal, and mechanism-linked biomarkers that can guide decisions for individual patients.

A second major cluster centers on immune regulation and immune evasion, particularly where metabolism and redox biology shape immune function. Tumor-derived antioxidants (e.g., extracellular PRDX1) and lactate-driven tolerogenic signaling in influenza both illustrate how local metabolic environments can blunt protective immunity. Multiple studies further dissect actionable immune circuitry—ranging from engineered T-cell approaches (CHAR T cells, dual-target CAR T) and TCR pairing constraints to NK-cell signaling organizers (CD55–CD97–LCK) and dendritic cell cross-presentation linking peripheral priming to neurodegeneration. Complement and itaconate-focused reviews add to this mechanistic landscape, suggesting expanding therapeutic opportunities in neuroinflammation and immunometabolism.

Finally, several papers highlight molecular and systems-level biology that underpins disease progression and therapeutic targeting: epigenetic/chromatin organization (cohesin condensates, replication-linked architecture, SetDB1 DNA methylation dynamics), ferroptosis regulation (iron bioavailability, MRPL35/PEBP1 pathways), and metabolic/mitochondrial capacity as functional biomarkers (PBMC respiration, molecular aging trajectories). In parallel, clinical oncology and hematology trials provide longer-horizon or mechanistically guided evidence (e.g., perioperative durvalumab in resectable NSCLC, CUPISCO molecularly guided therapy, and long-term LACEWING outcomes), underscoring how translational mechanistic insights are increasingly being tested in real-world decision pathways.

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Cancer immunology & tumor microenvironment immune evasion

MRPL35 Suppresses Autophagy-Mediated Ferroptosis in Hepatocellular Carcinoma via the AMPK/mTOR Axis.

This study examined how mitochondrial ribosomal protein L35 (MRPL35) regulates autophagy-dependent ferroptosis in hepatocellular carcinoma (HCC) cells and related mechanisms involving the AMPK/mTOR axis. MRPL35 suppressed autophagy-mediated ferroptosis, with experiments using RT-qPCR and western blotting plus functional assays (e.g., proliferation/migration and flow cytometry) supporting an AMPK/mTOR-dependent protective effect. These findings suggest MRPL35 as a potential therapeutic target to modulate ferroptosis and autophagy pathways in HCC.

Xu Y, Xiao L, Shi Z et al. · Current cancer drug targets · (2026) · View on PubMed ↗

Tape Strip Transcriptomics Reveal Nemolizumab Effects on Pruritus, Hyperplasia, Inflammation, and Extracellular Matrix Markers in Patients With Moderate-to-Severe Atopic Dermatitis.

This study used tape-strip transcriptomics (bulk RNA-seq) to assess molecular effects of nemolizumab, an anti-IL-31Rα monoclonal antibody, in patients with moderate-to-severe atopic dermatitis from the ARCADIA 1 and 2 trials. After 16 weeks, nemolizumab-treated patients showed changes in pruritus-, inflammation-, hyperplasia-, and extracellular matrix–related gene expression compared with placebo. The results support IL-31Rα blockade as a mechanistically grounded therapy and identify transcriptomic biomarkers that may help track response in adolescent and adult AD patients.

Liu D, Duca ED, Delaleu N et al. · Allergy · (2026) · View on PubMed ↗ · Free PDF ↗

IL-17A-producing γδ T cells control pulmonary Mycobacterium abscessus infection in mice.

This mouse study investigated how IL-17A-producing γδ T cells control pulmonary infection with Mycobacterium abscessus. IL-17A+ γδ T cells were essential for controlling infection by directly eliminating extracellular bacteria, including via granzyme B–dependent cytotoxic pathways, and they conferred protection in models with pulmonary fibrosis or impaired IFNγ-mediated immunity. The work identifies a specific innate-like T-cell effector mechanism that could inform immunotherapeutic strategies for non-tuberculous mycobacterial lung disease.

Hu X, Lin S, Meng W et al. · Nature microbiology · (2026) · View on PubMed ↗

CD55 organizes lipid raft-LCK signaling to potentiate NK-cell antitumor immunity.

This study identified CD55 as an inducible membrane organizer in NK cells that coordinates activating receptor signaling to enhance antitumor immunity. Upon tumor encounter, NK cells upregulated CD55 through an NKG2D–p65 transcriptional axis, and CD55 engaged tumor-expressed CD97 in trans to drive lipid raft aggregation and LCK activation, promoting cytotoxicity. The findings reveal a CD55–CD97–LCK signaling axis as a potential target to restore NK-cell function in the tumor microenvironment.

Li L, Li Z, Liu Y et al. · Cell research · (2026) · View on PubMed ↗

Priming of CD8+ T cells by peripheral dendritic cells exacerbates tau-mediated neurodegeneration.

The study examined how peripheral conventional type 1 dendritic cells (cDC1s) prime CD8+ T cells to drive tau-mediated neurodegeneration in tauopathy mouse models. Mice lacking cDC1s or antigen cross-presentation were protected from neurodegeneration, with reduced brain CD8+ T-cell infiltration and glial activation and evidence of impaired CD8+ clonal expansion. These findings identify cDC1 antigen cross-presentation as a mechanistic bridge between peripheral CD8+ T-cell priming and worsening tau pathology, suggesting a potential immunomodulatory target for primary tauopathies and Alzheimer’s disease–related tau neurodegeneration.

Hu H, Lin PB, Zeng C et al. · Nature neuroscience · (2026) · View on PubMed ↗ · Free PDF ↗

Role of complement and complement-targeted therapeutics in neurological diseases.

This review analyzed the role of complement biology in neurological diseases and summarized complement-targeted therapeutics across conditions with complement-driven pathology. It highlights that most approved therapies target complement pathways in disorders driven by complement-fixing pathogenic antibodies (e.g., myasthenia gravis and neuromyelitis optica spectrum disorder), while an expanding pipeline is emerging for broader neurological indications. The work is clinically significant because it frames how complement inhibition could be tailored to distinct mechanisms of neuroinflammation, synaptic injury, and immune dysregulation.

Dalakas MC, Lünemann JD · Nature reviews. Neurology · (2026) · View on PubMed ↗

CAFs shape the immunosuppressive microenvironment of pancreatic cancer through the Lin28b-STING Axis.

The study investigated how Lin28b+ cancer-associated fibroblasts (CAFs) regulate the pancreatic ductal adenocarcinoma immune microenvironment via the Lin28b–STING axis. Lin28b directly bound STING mRNA to promote its degradation, suppressing cGAS–STING–type I interferon signaling and thereby reducing dendritic cell antigen presentation and CD8+ T-cell cytotoxic activity, while Lin28b loss activated this pathway. These results are significant because they mechanistically link a CAF-intrinsic RNA-binding program (Lin28b) to impaired anti-tumor immunity and suggest that restoring STING signaling in CAFs could improve responses in “cold” pancreatic cancers.

Fan M, Zhang Z, Xu W et al. · Nature communications · (2026) · View on PubMed ↗ · Free PDF ↗

Itaconate and its derivatives in human health and diseases.

This review summarized the roles of itaconate and its derivatives in human health and disease, emphasizing the IRG1/ACOD1–itaconate immunometabolic axis. Itaconate is described as an immunometabolic “brake” that links the tricarboxylic acid cycle to inflammatory signaling and redox control across infectious, metabolic, ischemia–reperfusion, neurodegenerative, and autoimmune contexts. The scientific significance lies in consolidating mechanistic pathways that could be leveraged to develop itaconate-based or itaconate-pathway therapeutics for inflammatory and neuroinflammatory disorders.

Gu J, Zhang W, Zhang J et al. · Signal transduction and targeted therapy · (2026) · View on PubMed ↗ · Free PDF ↗

Aging microenvironment induces CD8+ T cell exhaustion by suppressing hepatic β-hydroxybutyrylate synthesis.

This study examined how an aged hepatic microenvironment affects CD8+ T cell exhaustion and antitumor/antiviral immunity, focusing on β-hydroxybutyrate (3HB) metabolism in mice. Aging repressed hepatic BDH1-dependent 3HB synthesis, limiting SLC16A1-mediated 3HB uptake and thereby reducing 3HB-dependent β-hydroxybutyrylation; hepatic BDH1 ablation reproduced age-associated CD8+ dysfunction, while 3HB supplementation reversed it, with a 3HB-derived chemical probe (3Halk) and functional screening implicating PRKAR1B as a key 3HB signaling effector. These findings identify a BDH1–3HB–PRKAR1B axis that could be therapeutically targeted to restore CD8+ T cell function during aging.

Xiao Y, Zhang Y, Zhao Z et al. · Cell metabolism · (2026) · View on PubMed ↗

Metabolite buffering of labile iron governs ferroptosis.

This commentary discusses new findings on how metabolite buffering controls ferroptosis sensitivity by regulating labile iron accessibility. It highlights that polyamines act as endogenous metabolic buffers that reduce chemical accessibility of labile iron, thereby influencing ferroptosis, and notes that this reveals an unexpected role for polyamines while raising questions about intracellular iron metabolism organization. The perspective reframes ferroptosis as governed by iron bioavailability rather than total iron abundance, informing future therapeutic targeting.

Megarioti AH, Olzmann JA · Cell · (2026) · View on PubMed ↗

Piezo1 agonists are potent off-target inhibitors of the Kv1.3 channel via gating modification.

This study characterized off-target pharmacology of Piezo1 agonists in relation to the Kv1.3 potassium channel using patch-clamp electrophysiology. Yoda1 and Yoda2, widely used Piezo1 agonists, state-independently inhibited Kv1.3 with micromolar IC50 values (Yoda1 IC50 9.0 μM; Yoda2 IC50 5.9 μM), indicating that reported effects on macrophage Ca2+ signaling may be confounded by Kv1.3 blockade. The findings are clinically important because they caution that Piezo1 agonist efficacy and immunomodulatory mechanisms in myeloid cells may require re-evaluation of Kv1.3-mediated contributions.

Huang K, Shim H, Wulff H et al. · Molecular pharmacology · (2026) · View on PubMed ↗ · Free PDF ↗

Single-Cell Analysis Guides Organoid CRISPR Screening to Reveal NF1 as a Gatekeeper of Cervical Squamous Malignant Transformation.

Using single-cell transcriptomics of patient-derived samples, CRISPR-Cas9 screening, and organoid modeling of HPV-positive cervical pre-tumoroids, this study identified genetic regulators of malignant transformation in cervical squamous cancer. NF1 emerged as a top suppressor (“gatekeeper”) of malignant transition, and NF1 loss accelerated carcinogenesis in organoids. These results nominate NF1 as a potential target for preventing or delaying HPV-driven cervical malignant transformation.

Hu B, Chen L, Wang R et al. · Cancer research · (2026) · View on PubMed ↗ · Free PDF ↗

Psilocybin prevents chemotherapy-induced peripheral neuropathy through mitochondrial trafficking preservation.

This preclinical study tested whether psilocybin given before chemotherapy prevents chemotherapy-induced peripheral neuropathy (CIPN) in platinum- and taxane-based models, including repeated chemotherapy cycles. Two doses of psilocybin durably prevented CIPN onset without impairing antitumor efficacy by preserving peripheral axonal mitochondrial trafficking and distribution via the TrkB–Akt–PAK5–MAP2–KIF5B pathway and remobilization of syntaphilin-anchored mitochondria. The findings suggest a mitochondria-trafficking–preserving mechanism for psilocybin as a candidate prophylactic to reduce CIPN in patients receiving neurotoxic chemotherapy.

Heles M, Pasvolsky L, Sathishkumar H et al. · Science (New York, N.Y.) · (2026) · 2 citations · View on PubMed ↗

Tumor-derived antioxidants suppress immunity by depriving T cells of reactive oxygen species.

This study tested how tumor-derived antioxidants affect T cell function in cancer models, focusing on reactive oxygen species (ROS) dependence. Tumors suppressed T cell-mediated antitumor immunity by releasing antioxidant enzymes—especially extracellular peroxiredoxin 1 (PRDX1)—into the tumor interstitium, depriving T cells of ROS needed for TCR-driven signaling. This provides a mechanistic explanation for why antioxidant-like strategies can fail clinically and identifies PRDX1/ROS deprivation as a potential immunotherapy target.

Wesolowski AJ, Pillay AM, Vardaka P et al. · Science (New York, N.Y.) · (2026) · 1 citations · View on PubMed ↗

Neoadjuvant Anbenitamab and HB1801 in ERBB2-Positive Breast Cancer: A Phase 3 Randomized Clinical Trial.

This phase 3 randomized clinical trial evaluated neoadjuvant anbenitamab (an ERBB2-biparatopic antibody) plus HB1801 (solvent-free albumin-bound docetaxel) versus standard neoadjuvant ERBB2-targeted therapy in patients with early ERBB2-positive breast cancer. The study tested whether adding anbenitamab to HB1801 improves efficacy without increasing toxicity, building on prior antitumor activity of anbenitamab and HB1801. If effective, this regimen could expand neoadjuvant options for ERBB2-positive breast cancer by leveraging ERBB2 receptor clustering with an albumin-bound taxane to improve pathologic response while maintaining safety.

Li J, Liu T, Yu KD et al. · JAMA oncology · (2026) · View on PubMed ↗ · Free PDF ↗

Cusatuzumab combined with venetoclax with or without azacitidine in unfit patients with newly diagnosed acute myeloid leukemia: phase Ib ELEVATE study.

This phase Ib ELEVATE study evaluated the safety, tolerability, and efficacy of adding cusatuzumab (anti-CD70 monoclonal antibody) to standard-of-care azacitidine plus venetoclax (CVA) or cusatuzumab plus venetoclax (CV) in newly diagnosed acute myeloid leukemia (AML) patients ineligible for intensive chemotherapy. Cusatuzumab 20 mg/kg IV on days 3 and 17 of 28-day cycles was tested in 44 patients receiving CVA, with the abstract reporting common hematologic treatment-emergent adverse events (details truncated). The study is clinically significant because it targets CD70 on CD34+ AML progenitors/leukemia stem cells to potentially improve outcomes in a high-risk, treatment-ineligible AML population.

Roboz GJ, Pabst T, Aribi A et al. · Haematologica · (2026) · View on PubMed ↗ · Free PDF ↗

PEBP1 Regulates Ferroptosis in Acute Glaucoma: Targeted Therapy Using Engineered Exosomes.

This study investigated PEBP1’s role in ferroptosis during acute glaucoma and tested targeted therapy using engineered exosomes in a rat model of pathological high intraocular pressure (ph-IOP). Using single-cell RNA sequencing and spatial transcriptomics to map retinal changes across acute, subacute, and chronic stages, the authors report a ferroptosis-focused therapeutic rationale tied to PEBP1 regulation (details truncated). The work is significant because it aims to enable faster, target-specific intervention for acute retinal ganglion cell loss compared with slow-onset gene therapy approaches.

Huang Y, Gong D, Guo J et al. · FASEB journal : official publication of the Federation of American Societies for Experimental Biology · (2026) · View on PubMed ↗ · Free PDF ↗

Measurable residual KMT2A partial tandem duplication before allogeneic stem cell transplantation in acute myeloid leukemia.

This retrospective study evaluated whether KMT2A partial tandem duplication (KMT2A-PTD) measurable residual disease (MRD) status before allogeneic hematopoietic stem cell transplantation (allo-HSCT) predicts outcomes in AML. In 180 KMT2A-PTD AML patients, pre-transplant MRD was quantified by real-time quantitative PCR with positivity defined as ≥1500 copies/10^5 ABL1, and 34/144 (24%) were MRD-positive among those assessed in complete remission. The clinical significance is that pre-transplant KMT2A-PTD MRD measured by qPCR may help risk-stratify patients undergoing allo-HSCT.

Wang L, Fu H, Qin Y et al. · Haematologica · (2026) · View on PubMed ↗ · Free PDF ↗

Efficacy and safety of bridging therapy prior to CAR T-cell therapy in relapsed or refractory multiple myeloma.

This multicenter real-world cohort study examined the efficacy and safety of bridging therapy before BCMA-directed CAR T-cell therapy in relapsed/refractory multiple myeloma (RRMM). Among 399 patients treated with BCMA CAR T, 348 (87%) received bridging therapy, and bridging recipients had more advanced and adverse disease features (including higher rates of high-risk cytogenetics and penta-class refractoriness). The significance is that it clarifies how bridging therapy may influence outcomes in a biologically higher-risk RRMM population receiving CAR T.

Wesener MC, Demel UM, Pabst T et al. · Haematologica · (2026) · View on PubMed ↗ · Free PDF ↗

Exposure-response and dose simulation of belantamab mafodotin in combination with standards of care in patients with relapsed/refractory multiple myeloma.

This analysis studied exposure-response relationships and dose simulation for belantamab mafodotin when combined with standard-of-care regimens in RRMM, using Cycle 1 exposure data from DREAMM-6, DREAMM-7, and DREAMM-8. It also simulated the BVd (bortezomib, dexamethasone) dosing regimen using a previously validated framework to support benefit–risk decisions aimed at improving outcomes and managing ocular events. Scientifically and clinically, the work is significant because it informs optimized belantamab mafodotin dosing strategies to balance efficacy with toxicity.

Lonial S, Richardson PG, Ferron-Brady G et al. · Haematologica · (2026) · View on PubMed ↗ · Free PDF ↗

Pediatric-inspired therapy and blinatumomab consolidation improve outcomes in young adults with Philadelphia-like acute lymphoblastic leukemia.

This retrospective study analyzed 140 adult patients with Philadelphia-like (Ph-like) acute lymphoblastic leukemia (ALL) treated at a single institution, characterizing CRLF2 rearrangements, IKZF1plus deletion, and JAK mutations and comparing pediatric-inspired regimens (PIR) versus non-PIR. Pediatric-inspired therapy was associated with higher complete remission (CR) rates and improved measurable residual disease (MRD) clearance, with additional benefit reported for blinatumomab consolidation in young adults. These findings support a Ph-like ALL treatment strategy that combines PIR with blinatumomab consolidation to improve depth of response and survival in a genomically high-risk adult population.

Aldoss I, Li A, Knobler D et al. · Haematologica · (2026) · View on PubMed ↗ · Free PDF ↗

Overall survival and long-term outcomes from the randomized, double-blind, placebo-controlled, phase III IMerge trial of imetelstat for lower-risk myelodysplastic syndromes.

This randomized, double-blind, placebo-controlled phase III IMerge trial evaluated imetelstat in patients with lower-risk myelodysplastic syndromes, assessing overall survival and long-term outcomes. The abstract provided no results, so the key efficacy/safety findings cannot be determined from the supplied text. Clinically, IMerge is designed to establish whether imetelstat provides durable benefit in lower-risk MDS, which would meaningfully affect long-term management decisions if positive.

Santini V, Komrokji RS, Savona MR et al. · Haematologica · (2026) · View on PubMed ↗ · Free PDF ↗

Gilteritinib plus azacitidine in patients with newly diagnosed FLT3 mutation-positive acute myeloid leukemia who were ineligible for intensive chemotherapy: final results of the phase III LACEWING study.

The phase III LACEWING study evaluated the FLT3 inhibitor gilteritinib (GIL) plus azacitidine (AZA) versus gilteritinib alone or azacitidine alone in newly diagnosed FLT3 mutation-positive AML patients ineligible for intensive chemotherapy (safety cohort n=15; randomized n=168). Final 6.5-year outcomes showed similar overall survival between GIL+AZA and AZA (median OS 9.82 vs 9.23 months; p=0.182), with lower OS for GIL monotherapy (median OS 5.24 months). These long-term data inform regimen selection for older/unfit FLT3-mutated AML patients by clarifying that adding gilteritinib to azacitidine did not demonstrate a statistically significant OS advantage over azacitidine alone in this population.

Wang ES, Montesinos P, Minden MD et al. · Haematologica · (2026) · View on PubMed ↗ · Free PDF ↗

Renal Synovial Sarcoma Revisited: Clinicopathologic and Molecular Insights From 70 Cases With Report of a Rare SS18::NEDD4 Fusion.

This multi-institutional clinicopathologic series analyzed 70 cases of primary renal synovial sarcoma to characterize clinical features and molecular findings, including a reported rare SS18::NEDD4 fusion. The study compiled comprehensive histopathologic and clinical data and highlighted molecular insights from this fusion-positive subset. By expanding the evidence base for primary renal synovial sarcoma and documenting SS18::NEDD4, it improves diagnostic precision and may guide future targeted or prognostic stratification.

Tan HM, Bayrak BY, Collins K et al. · The American journal of surgical pathology · (2026) · View on PubMed ↗

Efficacy and Safety of Recibokibart, an Interleukin-36 Receptor Antibody, in Generalized Pustular Psoriasis: A Phase 2 Randomized Trial.

This multicenter randomized, double-blind, placebo-controlled phase 2 trial in China evaluated the IL-36 receptor–targeting humanized IgG1 monoclonal antibody recibokibart in patients with acute flares of generalized pustular psoriasis (GPP). The abstract indicates the trial was designed to assess efficacy and safety versus placebo, but the provided text is truncated before reporting the key efficacy/safety outcomes. If positive, targeting the IL-36 receptor with recibokibart could offer a mechanism-based option for rapid control of severe GPP flares.

Yang B, Li Y, Wang Y et al. · The British journal of dermatology · (2026) · View on PubMed ↗ · Free PDF ↗

Inadequate Disease Control with Current Therapies Among Patients with a History of Moderate-to-Severe Atopic Dermatitis.

This cross-sectional real-world survey (Adelphi Atopic Dermatitis Disease Specific Programme; Aug 2022–Mar 2023) assessed disease control and symptom burden in US adults with moderate-to-severe atopic dermatitis (AD) treated with topical-only or systemic therapies (conventional corticosteroids/immunosuppressants or advanced biologics/JAK inhibitors) ± topicals. The abstract truncates before reporting the magnitude of uncontrolled disease, so the key quantitative findings cannot be determined from the provided text. Clinically, the study addresses whether current AD therapies achieve adequate control in routine practice, which is critical for optimizing treatment selection and escalation strategies.

Lio P, Golant A, Chovatiya R et al. · Dermatitis : contact, atopic, occupational, drug · (2026) · View on PubMed ↗ · Free PDF ↗

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Gastroenterology/hepatology endoscopy & liver disease endpoints

2026 iCatCare consensus guidelines on the diagnosis and management of chronic kidney disease in cats.

This consensus guideline article reviewed evidence and provided practical recommendations for diagnosing and managing chronic kidney disease (CKD) in cats using the International Renal Interest Society (IRIS) staging framework. It emphasizes early diagnosis and structured medical and nutritional interventions to slow progression and improve quality of life in senior cats. Clinically, it standardizes CKD workup and treatment decisions for veterinary practice, aiming to prolong survival and reduce morbidity.

Taylor S, Finch N, Caney S et al. · Journal of feline medicine and surgery · (2026) · View on PubMed ↗ · Free PDF ↗

Biliary stricture management: European Society of Gastrointestinal Endoscopy (ESGE) Guideline.

This ESGE guideline article synthesized evidence and issued recommendations for endoscopic management of benign biliary strictures, including postcholecystectomy and post–liver transplantation anastomotic strictures. It recommends temporary placement of multiple plastic stents (MPSs) for postcholecystectomy strictures and suggests fully covered self-expandable metal stents (FCSEMS) in selected cases (e.g., strictures >2 cm distally from the main hepatic confluence or noncompliance with repeated ERCP), with similar options for liver-transplant anastomotic strictures. These guidance statements standardize technique selection to improve stricture resolution and reduce procedural burden.

Lemmers A, Tringali A, Teles de Campos S et al. · Endoscopy · (2026) · View on PubMed ↗

Clinical utility of a 30% reduction in VCTE-derived liver stiffness measurement for identifying histologic improvement in MASH.

This prospective multicenter phase 2b randomized placebo-controlled study tested whether a ≥30% relative decline in liver stiffness measurement (LSM) by vibration-controlled transient elastography (VCTE) corresponds to histologic fibrosis regression in 160 adults with biopsy-proven metabolic dysfunction–associated steatohepatitis (MASH) and stage 2–3 fibrosis treated in a trial of an FGF21-based therapy. A 30% VCTE LSM reduction was associated with histologic improvement, supporting VCTE LSM decline as a noninvasive treatment-response endpoint for MASH fibrosis regression. Clinically, this can help accelerate and standardize response assessment in MASH trials and potentially in practice.

Loomba R, Chen R, Wang Y et al. · Hepatology (Baltimore, Md.) · (2026) · View on PubMed ↗

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Cardiovascular interventions & guideline/endpoint imaging

Percutaneous Coronary Intervention in Patients Undergoing Transcatheter Aortic Valve Implantation: A Systematic Review and Meta-Analysis With Reconstructed Individual Patient Data and GRADE Assessment.

This systematic review and meta-analysis reconstructed individual patient data from randomized trials to evaluate whether percutaneous coronary intervention (PCI) versus conservative management/deferral affects outcomes in transcatheter aortic valve implantation (TAVI) candidates with coronary artery disease. The analysis pooled randomized evidence and applied GRADE assessment to quantify comparative risks, using reconstructed Kaplan–Meier curves and random-effects models. Scientifically and clinically, it clarifies the role of PCI in TAVI patients with coexisting CAD, informing procedural decision-making and guideline development.

Yassin MN, Elfeqi K, Abdelmaksoud A et al. · Cardiology in review · (2026) · View on PubMed ↗

Prognostic Value of pc-ASPECTS Before Endovascular Therapy in Posterior Circulation Stroke: A Systematic Review and Meta-Analysis.

This systematic review and meta-analysis evaluated the prognostic performance of pc-ASPECTS (0–10) measured before endovascular therapy in posterior circulation stroke, across imaging modalities. It specifically assessed whether pc-ASPECTS predicts 90-day modified Rankin Scale outcomes depending on whether the score was derived from DWI, CTA source imaging (CTA-SI), or non-contrast CT. The clinical significance is that it informs how to standardize pc-ASPECTS acquisition for patient selection and outcome prediction prior to EVT.

Elek A, Kıran F, Valizadeh P et al. · AJNR. American journal of neuroradiology · (2026) · View on PubMed ↗ · Free PDF ↗

Clinical outcomes by type of surgery with perioperative durvalumab in patients with resectable non-small cell lung cancer.

This study analyzed perioperative durvalumab outcomes by surgical type in adults with treatment-naïve resectable stage II–IIIB(N2) non-small cell lung cancer (NSCLC) enrolled in the phase 3 AEGEAN trial (NCT03800134). Perioperative durvalumab improved key efficacy outcomes (including pathological complete response and event-free survival) across surgical approaches in the modified intent-to-treat population excluding patients with documented EGFR/ALK aberrations. These findings support the clinical use of perioperative durvalumab with standard neoadjuvant chemotherapy and adjuvant durvalumab regardless of the specific resection strategy in resectable NSCLC.

Harpole D, Heymach JV, Reck M et al. · The Journal of thoracic and cardiovascular surgery · (2026) · View on PubMed ↗

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Epigenetics, genome organization, and chromatin regulation

Beyond genes: EpiSwitch® and Orion platform-powered 3D genome architecture biomarkers reveal shared biology across ME/CFS, long COVID, PTSD, rheumatoid arthritis, and multiple sclerosis.

This study applied the EpiSwitch® 3D genomics platform and the Orion knowledgebase to integrate chromosome conformation signatures with genome-wide association data to find shared regulatory biology across ME/CFS, long COVID, PTSD, rheumatoid arthritis, and multiple sclerosis. The key finding was that these clinically distinct disorders show convergent 3D genome architecture–linked regulatory pathways and shared biomarker signals across conditions. This supports an epigenome/3D-genome–based framework for identifying common mechanisms and potential cross-disease therapeutic targets.

Hunter E, Alshaker H, Vugrinec D et al. · Journal of translational medicine · (2026) · View on PubMed ↗ · Free PDF ↗

Nuclear exosome targeting complexes modulate cohesin binding and enhancer-promoter interactions in 3D.

The study examined whether nuclear exosome targeting complexes influence 3D genome organization by modulating cohesin binding and enhancer–promoter contacts. Using chromatin recruitment mapping of the nuclear exosome targeting complex (truncated in the abstract), the authors report that these RNA-decay targeting systems can alter cohesin occupancy and thereby reshape enhancer–promoter connectivity. This is scientifically important because it connects noncoding RNA turnover by the nuclear exosome to higher-order chromatin architecture and gene regulation.

Akkawi C, Heurteau A, Contreras X et al. · Nature communications · (2026) · View on PubMed ↗

MBNL depletion drives stem cell fusion and immature myonuclear states in myotonic dystrophy type 1.

The study investigated the consequences of MBNL depletion in myotonic dystrophy type 1 (DM1), focusing on skeletal muscle stem cell behavior and myonuclear states. Single-nucleus transcriptomics of patient muscle showed increased activated muscle stem cells and distinct transitional myonuclear populations, consistent with stem cell activation and fusion with existing muscle fibers in DM1. These findings are clinically significant because they implicate MBNL loss in driving aberrant muscle regeneration programs, offering mechanistic targets for modifying disease progression in DM1.

Todorow V, Lornage X, Hayashi S et al. · Nature communications · (2026) · View on PubMed ↗ · Free PDF ↗

Networks of sexually dimorphic neurons that regulate social behaviors in Drosophila.

This study mapped and functionally analyzed sexually dimorphic pC1/pC1x neurons in Drosophila that regulate mating and aggressive social behaviors. It showed that male pC1/pC1x neurons form an expansive, highly interconnected male-specific network with heterogeneous synaptic wiring, including subsets receiving strong input from identified sensory pathways, and used genetic driver lines to assign distinct roles to cell types. These connectome- and genetics-based results identify circuit components that causally shape sex-specific social behavior in vivo.

Rubin GM, Managan CM, Dreher M et al. · Current biology : CB · (2026) · View on PubMed ↗ · Free PDF ↗

Epi-Allele elicits compensatory expression of the non-targeted allele and prevents haploinsufficiency in dominant genetic diseases.

This Cell Stem Cell study developed an allele-specific epigenetic editing therapy (“Epi-Allele”) to silence pathogenic alleles in dominant genetic diseases and tested its effects on allelic expression. The key finding was that silencing the targeted allele triggered compensatory upregulation of the non-targeted allele, preserving total gene expression and preventing haploinsufficiency. This mechanism suggests a therapeutic route for dominant disorders that avoids the expression loss seen with conventional allele-specific silencing approaches.

Wang Z, Han C, Huang Y et al. · Cell stem cell · (2026) · View on PubMed ↗ · Free PDF ↗

A descending glycinergic circuit drives opioid-resistant mechanical pain via spinal GluN3A excitatory glycine receptors in mice.

This study investigated the neural circuitry and receptor mechanism underlying opioid-resistant mechanical pain in mice, mapping a descending glycinergic pathway. A GlyT2-positive rostral ventromedial medulla circuit to spinal somatostatin neurons (RVMGlyT2+→SDHSOM+) was necessary and sufficient for widespread morphine-resistant mechanical allodynia, and glycine released from RVMGlyT2+ terminals activated GluN3A-containing NMDA receptors on SDHSOM+ neurons as unconventional excitatory glycine receptors. The work links GluN3A to opioid-resistant pain circuitry, suggesting a potential target distinct from classical opioid pathways.

Dong D, Huo J, Yin G et al. · Neuron · (2026) · View on PubMed ↗

Methylome profiling of SetDB1-deficient ESCs reveals coordinated epigenetic cross-talk during pluripotency.

This study profiled DNA methylation (DNAme) dynamics in SetDB1-deficient mouse embryonic stem cells (ESCs) to define epigenetic cross-talk during pluripotency, using time-course whole-genome bisulfite sequencing. Setdb1 knockout reduced both H3K9me3 and DNAme, with rapid TET-mediated DNAme removal at many sites, and nearly half of SetDB1 binding sites enriched for DNAme and H3K9me3—especially at retrotransposons—indicating coordinated regulation between SetDB1-associated histone methylation and DNA methylation. These results clarify how SetDB1 coordinates multiple epigenetic layers to maintain pluripotent genome stability and transposon control.

Bovee NGP, Habibi E, Liu Z et al. · Stem cell reports · (2026) · View on PubMed ↗ · Free PDF ↗

The organization of visual pathways in the Drosophila brain.

This study mapped how visual information is routed through the Drosophila brain using the male Drosophila connectome, tracing signals from photoreceptors through optic lobe retinotopic layers into the central brain. Network-based analyses revealed a multilayered architecture of pathway classes with distinct input mixtures, where visual-input channels spread broadly but converge in focal regions. The resulting wiring-level framework explains how hierarchical feature extraction is implemented across an entire brain.

Hoeller J, Zhao A, Nern A et al. · Cell · (2026) · View on PubMed ↗ · Free PDF ↗

The complete gustatory connectome of adult Drosophila reveals how taste guides feeding, foraging, and social behavior.

This study reconstructed the complete gustatory connectome of adult male Drosophila to determine how taste receptor neurons guide feeding, foraging, and social behaviors. Using contiguous electron microscopy across brain, cervical connective, and ventral nerve cord, the authors built a pan-CNS cross-sex connectome that reconstructs gustatory receptor neurons (GRNs), revealing GRN diversity via connectivity-based clustering and molecular identity mapping. The comprehensive wiring diagram provides a mechanistic substrate for linking specific taste inputs to distinct behavioral outputs.

Tastekin I, de Haan Vicente I, Beresford RJ et al. · Cell · (2026) · 1 citations · View on PubMed ↗

Sexual dimorphism in the complete Drosophila male central nervous system connectome.

This study generated and analyzed the full male Drosophila central nervous system connectome to quantify sexual dimorphism at synaptic resolution. The authors reported 166,700 neurons with fruitless/doublesex expression and 11,710 neuron types, and found 8,069 isomorphic, 138 dimorphic, 289 male-specific, and 71 female-specific neuron types when comparing male and female connectomes. This provides a circuit-level map of how sex-determination transcription factors (fruitless/doublesex) translate into structural neural differences that can underlie sex-specific behaviors.

Berg S, Beckett IR, Costa M et al. · Cell · (2026) · View on PubMed ↗ · Free PDF ↗

The regulatory logic linking inflammation and fibrosis.

This article is a regulatory framework review examining how immune cells and fibroblasts integrate intercellular cues through chromatin-regulated gene circuits to decide between tissue recovery and chronic fibrosis. It proposes that immune–stromal crosstalk and gene regulatory network logic across organs (including heart, lung, liver, and kidney) governs cell state and fate during injury resolution versus scarring. The synthesis highlights actionable molecular circuit principles that could guide antifibrotic strategies.

Alexanian M, Srivastava D · Cell · (2026) · View on PubMed ↗ · Free PDF ↗

Hypertranscription caused by p53 deficiency triggers nucleotide insufficiency that induces replication stress and genomic instability.

This study tested how p53 deficiency drives catastrophic genome instability by triggering nucleotide insufficiency, using p53-depleted epithelial cells and fibroblasts plus patient-derived fibroblasts with germline p53 variants that undergo chromothripsis. Loss of p53 caused hypertranscription and increased nucleotide consumption, leading to nucleotide shortage, replication stress, and downstream genomic instability events including telomere dysfunction. These results identify nucleotide insufficiency as a mechanistic trigger linking p53 loss to replication stress and chromothripsis-associated tumorigenesis.

Zaatra W, Philippos G, Smirnov P et al. · Molecular cell · (2026) · View on PubMed ↗ · Free PDF ↗

An embryo-derived peptide signal directs endosperm polarity in Arabidopsis.

In Arabidopsis seed development, this study investigated how an embryo-derived peptide signal establishes endosperm polarity by combining genetic and molecular analyses of receptor and transcription factor pathways. It showed that the receptor kinase HAIKU2 (IKU2) coordinates with WRKY10/MINISEED3 (MINI3) to ensure robust endosperm polarity through WOX8 and WOX9 activity, depending on egg-cell fertilization. This clarifies the signaling logic that couples embryo-derived cues to polarized endosperm organization required for efficient nutrient transfer.

Creff A, Rhodes J, Salaün C et al. · Science (New York, N.Y.) · (2026) · View on PubMed ↗ · Free PDF ↗

Thalamic NRXN1-mediated input to human cortical progenitors drives excitatory neurogenesis.

This study used fused cortical and thalamic organoids plus single-nuclei RNA sequencing and cellular imaging to determine how thalamic projections influence early human cortical development. Thalamic input increased production of cortical excitatory neurons, with neurexin-1 (NRXN1) mediating physical contact between thalamic axons and cortical outer radial glia; thalamic NRXN1 knockout reduced this excitatory neurogenesis. The work identifies NRXN1-dependent thalamic signaling as a key driver of excitatory neuron generation during human cortical development.

Nguyen CV, Martija A, Jaklic DC et al. · Science (New York, N.Y.) · (2026) · View on PubMed ↗

Conformational asymmetry of replicated human chromosomes.

This study investigated how DNA replication asymmetry shapes chromosome organization in human cells using sister chromatid-sensitive conformation analysis. Sister chromatids were consistently misaligned in the 5’→3’ direction of inherited DNA strands, the shift persisted without cohesin-mediated loop extrusion, and it was lost when cohesion was disrupted. The results indicate that directional misalignment of cohesive cohesins can explain replication-linked chromosome architecture, informing models of genome organization and segregation.

Corsi F, Steinacker TL, Kolesnikova S et al. · Science (New York, N.Y.) · (2026) · 3 citations · View on PubMed ↗ · Free PDF ↗

In extracto cryo-EM reveals eEF2 as a major hibernation factor on 60S and 80S particles.

This eLife study used extracto cryo-EM (cryo-EM of cellular lysates) with high-resolution 2D template matching to identify translation factors on ribosomes in situ. The key finding was that eEF2 (eukaryotic elongation factor 2) acts as a major hibernation factor on 60S and 80S particles, revealed by ~2.2 Å maps of the mammalian translational apparatus. Scientifically, it advances in situ ribosome biology by showing how extracto cryo-EM can resolve factor–ribosome states that reflect cellular translational control.

Seraj Z, Zottig X, Huang C et al. · eLife · (2026) · View on PubMed ↗ · Free PDF ↗

Bridging-driven condensation by eukaryotic SMC complexes is a conserved feature of genome organization.

This study investigated whether eukaryotic SMC complexes (cohesin/condensin family) can drive genome organization via chromatin condensation mechanisms beyond ATP-dependent loop extrusion, using single-molecule fluorescence imaging. The authors found a conserved ATP-independent mechanism in which diverse SMCs form dynamic DNA-bound condensates exhibiting biomolecular condensate behaviors such as droplet coalescence and fluorescence recovery after photobleaching. Scientifically, this reframes higher-order chromosome architecture by adding biomolecular condensation as a conserved principle of SMC-driven genome organization.

Jang JW, Higashi TL, Tang M et al. · Nucleic acids research · (2026) · View on PubMed ↗ · Free PDF ↗

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Inflammation biomarkers & cardiometabolic risk

Evaluative performance of triglyceride-glucose-frailty index versus surrogate insulin resistance indices for advanced cardiovascular-kidney-metabolic syndrome, cardiometabolic multimorbidity, and mortality: the role of estimated glomerular filtration rate.

This observational study evaluated whether the triglyceride-glucose-frailty index (TyG-FI) predicts advanced cardiovascular-kidney-metabolic (CKM) syndrome, cardiometabolic multimorbidity (CMM), and mortality better than surrogate insulin resistance indices, considering baseline estimated glomerular filtration rate (eGFR). Using NHANES 2001–2018 data from 11,228 adults aged 20–79 years, TyG-FI showed stronger associations with CKM/CMM severity and mortality outcomes, with eGFR influencing these relationships. The findings suggest TyG-FI could be a practical composite risk stratification tool for cardiometabolic multimorbidity, especially in people with impaired kidney function.

Liu K, Zhang JY, He H et al. · Cardiovascular diabetology · (2026) · View on PubMed ↗ · Free PDF ↗

Genetic evidence supports the combined targeting of lipoprotein(a) and LDL cholesterol to reduce coronary artery disease risk.

This genetic epidemiology study used coding loss-of-function variants in LPA and PCSK9, along with genetic scores for lipoprotein(a) (Lp(a)) and LDL cholesterol, to test whether combined lowering reduces coronary artery disease (CAD) risk. In 408,039 UK Biobank participants, individuals carrying both LPA and PCSK9 loss-of-function variants had lower CAD risk than carriers of either alone, indicating additive benefit. These results provide genetic evidence supporting dual targeting of Lp(a) and LDL-C as a strategy to reduce CAD risk.

Wang S, Tang Y, Sui Y et al. · Nature cardiovascular research · (2026) · View on PubMed ↗

Cannabigerol, a minor phytocannabinoid, prevents behavioral changes induced by psychotomimetic drugs.

The study tested whether cannabigerol (CBG), a minor phytocannabinoid, prevents behavioral changes induced by psychotomimetic drugs in animal models relevant to schizophrenia-like phenotypes. CBG was evaluated for an antipsychotic-like behavioral effect, motivated by its lack of psychotomimetic properties and partial pharmacological similarity to cannabidiol (CBD). The scientific significance is that it supports CBG as a candidate compound for modulating psychotomimetic-induced behavioral abnormalities with potentially different side-effect profiles than conventional antipsychotics.

Pedrazzi JFC, Sales AJ, Hallak JEC et al. · Progress in neuro-psychopharmacology & biological psychiatry · (2026) · View on PubMed ↗

Impact of Family History on Colorectal Cancer Risk in Inflammatory Bowel Disease and in Matched General Population Comparators.

This nationwide register-based cohort study (1996–2023) evaluated how colorectal cancer (CRC) family history modifies CRC incidence in people with inflammatory bowel disease (IBD) versus matched general-population comparators. Over a median 11-year follow-up, CRC incidence rates and the interaction between IBD and family history were quantified by number of first-degree relatives and their age at CRC diagnosis (<50 vs ≥50). The results clarify whether inherited risk stratifies CRC surveillance and prevention strategies for patients with IBD.

Everhov ÅH, Kristjánsson K, Ludvigsson JF et al. · Gastroenterology · (2026) · View on PubMed ↗ · Free PDF ↗

Natural history and clinical impact of epilepsy in adults with Down syndrome: a multicentre clinical study.

This multicentre observational longitudinal study across seven international cohorts examined the natural history of epilepsy in adults with Down syndrome and its relationship to Alzheimer’s disease (including late-onset myoclonic epilepsy in Down syndrome, LOMEDS). It characterized when epilepsy emerges relative to Alzheimer’s symptom onset and assessed how epilepsy affects prognosis. Scientifically and clinically, the findings improve timing of monitoring and risk stratification for neurological decline in aging adults with Down syndrome.

Maure-Blesa L, Carmona-Iragui M, Barroeta I et al. · Lancet (London, England) · (2026) · View on PubMed ↗

Evaluation of Disease Severity Using CSF Biomarkers in Patients With Probable Cerebral Amyloid Angiopathy.

This retrospective multicenter cohort study evaluated whether cerebrospinal fluid (CSF) β-amyloid 1-42 (Aβ42) and β-amyloid 1-40 (Aβ40) biomarkers in patients with probable cerebral amyloid angiopathy (CAA) diagnosed by Boston criteria v2.0 better reflect MRI markers of hemorrhagic and nonhemorrhagic disease severity. CSF amyloid measures were associated with MRI severity features, supporting CSF biomarkers as a more direct readout of vascular amyloid burden than downstream imaging injury markers. These findings could improve risk stratification and monitoring in probable CAA by incorporating CSF Aβ42/Aβ40 into severity assessment.

Beaufort Q, Charbonnier C, Ruellan P et al. · Neurology · (2026) · View on PubMed ↗

Mindfulness-based stress reduction interventions and cortisol regulation: A systematic review and meta-analysis.

This systematic review and meta-analysis synthesized mindfulness-based stress reduction (MBSR) trials that reported pre- and postintervention cortisol levels with controlled timing of cortisol collection. Across 39 studies (n=2,059), MBSR showed measurable effects on cortisol regulation compared with baseline (and/or across study designs), indicating that MBSR can influence this physiological stress biomarker. The results support cortisol as a mechanistic target for MBSR and help refine expectations for stress physiology outcomes in chronic stress interventions.

Johnson BT, Simon TJ, Li C et al. · Health psychology : official journal of the Division of Health Psychology, American Psychological Association · (2026) · View on PubMed ↗

Parental depression in offspring’s internalization of stigma: A family-individual model of self-stigma.

This cross-sectional survey study of 1,012 Chinese individuals with depression aged 13–30 years examined how parental depression relates to offspring internalization of stigma via a family–individual self-stigma model. Structural equation modeling supported the proposed pathways linking parental depression to higher self-stigma in offspring through both familial and individual factors. Understanding these mechanisms can inform family-focused stigma-reduction strategies to improve help-seeking and mental health outcomes in youth with depression.

Du N, Huang YT · The American journal of orthopsychiatry · (2026) · View on PubMed ↗

Longitudinal Trajectories of 3-Dimensional Eye Shape and Pathological Sequelae in High Myopia.

This 15-year longitudinal MRI cohort substudy from the Zhongshan High Myopia Cohort characterized 3-dimensional globe remodeling trajectories in 30 participants (60 eyes) with bilateral high myopia (spherical equivalent ≤ -6.00 D) and related baseline features to ocular outcomes. The key finding was how specific 3D eye-shape trajectory patterns over time associate with sight-threatening pathological sequelae. These results are significant because they enable risk stratification and earlier monitoring strategies for progression toward vision-threatening complications in high myopia.

Chen S, Li Y, Xuan M et al. · JAMA ophthalmology · (2026) · View on PubMed ↗

Changes in five cerebrospinal fluid and three plasma Alzheimer’s disease biomarkers across increasing brain amyloid-beta and tau pathology burden.

This post-mortem validation study assessed how cerebrospinal fluid (CSF) biomarkers (Aβ42/Aβ40, p-tau181, p-tau217, and derived ratios) and plasma biomarkers (p-tau217, p-tau217/Aβ42, and Aβ42/Aβ40) track with regional brain amyloid-β and tau pathology burden in 250 participants with ante-mortem CSF and/or plasma samples. The key finding was the pattern of associations between these CSF/plasma measures and semi-quantitative post-mortem Aβ and tau burden across multiple brain areas. Scientifically, this supports pathology-specific interpretation of AD blood/CSF biomarkers and helps refine which biomarker panels best reflect underlying Aβ/tau distribution.

Mastrangelo A, Baiardi S, Ruggeri E et al. · Acta neuropathologica · (2026) · View on PubMed ↗ · Free PDF ↗

Angiotensin II-driven TGF-β1 increases platelet PAR4 expression enhancing thrombotic risk in hypertension.

This study examined how angiotensin II–driven TGF-β1 signaling increases platelet protease-activated receptor 4 (PAR4) expression and thereby enhances thrombotic risk in hypertension. Using platelet samples from 150 hypertensive patients plus spontaneously hypertensive rats and L-NAME-induced hypertensive mice, with RNA-seq and flow cytometry alongside in vivo/ex vivo thrombosis and in vitro platelet assays, the key finding was that the TGF-β1–PAR4 axis promotes platelet hyperactivation and thrombosis. This is significant because it identifies PAR4 as a mechanistic link between hypertensive signaling and prothrombotic platelet behavior, suggesting potential targeted anti-thrombotic strategies.

Wang M, Liu Z, Chen Y et al. · European heart journal · (2026) · View on PubMed ↗ · Free PDF ↗

Pharmacotherapies for Co-Occurring Stimulant Use Disorder and Attention-Deficit/Hyperactivity Disorder: A Network Meta-Analysis.

This network meta-analysis synthesized evidence from 6 studies evaluating pharmacotherapies for adults with co-occurring stimulant use disorder (StUD) and attention-deficit/hyperactivity disorder (ADHD). The key finding was the comparative effectiveness of available medication strategies on stimulant use outcomes and ADHD symptom-related endpoints across the included trials. Clinically, it helps guide treatment selection for a high-burden comorbidity where evidence is limited and direct head-to-head comparisons are scarce.

Oliva HNP, Pulido-Saavedra A, Paredes Naveda AM et al. · The Journal of clinical psychiatry · (2026) · View on PubMed ↗

Cross-Sectional and Longitudinal Association Between Biological Aging Acceleration and the Risk of Osteoarthritis: A Cohort Study From UK Biobank.

This UK Biobank cohort study (n=332,261) examined whether biological aging acceleration—estimated using phenotypic age (PhenoAge) and Klemera-Doubal age (KDMAge) derived from nine clinical biomarkers—predicts incident and prevalent osteoarthritis (OA). Biological aging acceleration measured by these residual-based approaches was associated with higher risk of OA outcomes over follow-up. The results suggest that proteo-metabolic/clinical biomarker-based “biological age” could help identify individuals at elevated OA risk beyond chronological age.

Liu S, Wang W, Li C et al. · International journal of rheumatic diseases · (2026) · View on PubMed ↗

Residual Inflammatory Risk of Heart Failure and Atherosclerotic CVD in Diabetes: Look AHEAD Ancillary Study.

This Look AHEAD ancillary study examined associations of inflammatory biomarkers—high-sensitivity C-reactive protein (hs-CRP) and interleukin-6 (IL-6)—with incident atherosclerotic cardiovascular disease (ASCVD) and incident heart failure (HF) in participants with type 2 diabetes (T2D) and overweight/obesity. It found that baseline hs-CRP and IL-6 were associated with ASCVD and incident HF risk, and it evaluated whether intensive lifestyle intervention (ILI) targeting weight loss altered IL-6 levels. Scientifically and clinically, the results support inflammation as a mechanistic risk signal in T2D and help clarify whether lifestyle-induced weight loss modifies IL-6–related HF risk.

Patel KV, Chiu L, Garcia KR et al. · JACC. Heart failure · (2026) · View on PubMed ↗

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Gene editing, xenotransplantation, and regenerative medicine

Building and regenerating intestines by manipulating intestinal stem cells.

This review summarized how manipulating intestinal stem cells (ISCs) can build and regenerate intestinal tissue, drawing on the work of the NIDDK-sponsored Intestinal Stem Cell Consortium (ISCC) from 2009–2024. It highlights translational efforts to accelerate in vivo mucosal repair and move toward generating functioning intestinal tissue ex vivo. The article underscores ISC-based regenerative strategies as a unifying approach for diverse intestinal disorders, including developmental, infectious, inflammatory, and neoplastic conditions.

Kuo CJ, Blutt S, Donowitz M et al. · Nature reviews. Gastroenterology & hepatology · (2026) · View on PubMed ↗

Porcine kidney xenotransplantation as a bridge to allotransplantation: a first-in-human study.

This first-in-human study reported outcomes of a gene-edited porcine kidney xenotransplantation (EGEN-2784) used as a bridge to subsequent human allotransplantation in a patient with end-stage kidney disease. The key focus was whether the xenograft could provide sufficient clinical support while addressing durability, immune sensitization, and zoonotic infection risk before allotransplant. The work advances translational feasibility of xenotransplantation strategies that reduce waiting-time harm for patients awaiting allografts.

Riella LV, Borges TJ, Rosales IA et al. · Lancet (London, England) · (2026) · 1 citations · View on PubMed ↗

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Microbiome, infection, and toxin-mediated immune effects

New insights on Plasmodium gene expression from direct RNA sequencing.

The article reviewed how Oxford Nanopore Technology (ONT) direct RNA sequencing improves Plasmodium gene expression studies by sequencing native RNA molecules without cDNA conversion. It emphasizes that long-read direct RNA sequencing captures full-length transcripts spanning entire genes, enabling analysis of untranslated regions, isoforms, alternative splicing, non-coding RNAs, RNA modifications, and poly(A) tail dynamics. This is significant because it advances post-transcriptional understanding of Plasmodium biology and can guide future studies of gene regulation in clinically relevant parasite stages.

Grünebast J, Serre D · Trends in parasitology · (2026) · View on PubMed ↗ · Free PDF ↗

Comparative effectiveness of clarithromycin and azithromycin for pertussis in hospitalised infants in Italy: a multicentre target trial emulation study.

This multicentre target trial emulation study compared real-world effectiveness of clarithromycin versus azithromycin for treating pertussis in hospitalized infants in Italy. Using a retrospective cohort framework with TARGET reporting principles, it estimated comparative outcomes between the two macrolides among infants ≤12 months. The results help clinicians choose the more effective first-line macrolide for infant pertussis in routine care.

Lo Vecchio A, Moracas C, Poeta M et al. · The Lancet. Child & adolescent health · (2026) · View on PubMed ↗

Early-life colonization with Clostridioides difficile remodels the developing gut.

This study examined how early-life colonization with Clostridioides difficile affects intestinal development in a neonatal mouse model. C. difficile colonization triggered toxin-dependent proinflammatory and tissue-repair epithelial programs, enriched injury-associated intestinal stem cell populations, and skewed differentiation toward secretory lineages, with persistent adult alterations despite transient colonization. These findings suggest that asymptomatic infant colonization can have long-term, toxin-mediated consequences for gut maturation and may inform prevention strategies such as maternal C. difficile-targeted mRNA vaccination.

Semon A, Manzer HS, Keenan O et al. · Science (New York, N.Y.) · (2026) · 1 citations · View on PubMed ↗

Association between nirsevimab coverage and pediatric emergency department visits for bronchiolitis in 12 European countries: An interrupted time-series analysis.

This study assessed whether nirsevimab coverage was associated with variability in pediatric emergency department visits for bronchiolitis across 12 European countries using an interrupted time-series design. Using routinely collected data from 27 pediatric emergency departments (01/2018–03/2024) and classifying regions by nirsevimab implementation, it evaluated bronchiolitis cases in infants <12 months, including both in- and out-of-season births. The results are intended to clarify whether differences in preventive monoclonal antibody uptake explain cross-country bronchiolitis trends, informing RSV prevention strategies.

Lenglart L, Titomanlio L, Alberti I et al. · PLoS medicine · (2026) · View on PubMed ↗ · Free PDF ↗

Local lactate-driven H3K18 lactylation impairs anti-influenza immunity through NRF2-dependent dendritic cell dysfunction.

This study analyzed how lactate accumulation during influenza infection shapes antiviral immunity using time-series targeted energy metabolomics, single-cell RNA-seq, flow cytometry, and functional perturbations. Influenza increased lactate in the lung microenvironment, where extracellular lactate entered dendritic cells via monocarboxylate transporter (MCT)-dependent transport and induced a tolerogenic-like state with impaired maturation and costimulation, thereby restraining pulmonary CD8+ T cell responses. The results link local metabolic reprogramming (lactate–MCT–dendritic cell dysfunction) to defective anti-influenza immunity and suggest metabolic modulation as an adjunct strategy.

Lyu C, Xu J, Zhang Y et al. · Cell reports · (2026) · View on PubMed ↗ · Free PDF ↗

Lipid-mediated activation of BLT2 promotes membrane repair to prevent cell death.

This mechanistic study investigated how lipid-mediated activation of the leukotriene B4 receptor 2 (BLT2) promotes membrane repair to prevent cell death, focusing on epithelial protection against pneumolysin (PLY) in mouse models. The key finding was that the lipid mediator 12-hydroxyheptadecatrienoic acid (12-HHT), produced by membrane-damaged epithelial cells, activates BLT2 to drive membrane repair and reduce cell death. This is significant because it identifies a BLT2–lipid signaling axis as a potential therapeutic target to protect epithelial barriers during pneumococcal toxin exposure.

Chi Y, Saeki K, Yasukawa K et al. · The Journal of cell biology · (2026) · View on PubMed ↗

Sex-specific associations of the plasma-proteome with incident coronary artery disease.

This study used integrated genomic and proteomic analyses in 40,829 UK Biobank participants to identify sex-specific plasma-proteome associations with incident coronary artery disease (CAD) over a median 13.7-year follow-up. Sex-stratified Cox models across 2,922 plasma proteins identified proteins that were exclusive to women or men in their association with incident CAD. These findings suggest sex-specific biological pathways in CAD and support the development of sex-tailored biomarker strategies for risk prediction.

Sier VQ, Dimitrova K, Peters EHAB et al. · Cardiovascular research · (2026) · 1 citations · View on PubMed ↗ · Free PDF ↗

The Oral Microbiome of King Richard III of England.

This study analyzed the oral microbiome from dental calculus of King Richard III (1452–1485) by extracting DNA from three teeth and performing shotgun metagenomic sequencing to nearly 400 million reads. The metagenomic data were taxonomically profiled, de novo assembled, and compared with other ancient and modern European dental calculus metagenomes, with metagenome-assembled genomes assigned to the genus Tannerella. These results provide a high-resolution view of historical oral microbial communities and may inform how diet, environment, and oral health shaped microbiomes in the medieval period.

Velsko IM, Hübner A, Fagernäs Z et al. · American journal of biological anthropology · (2026) · 2 citations · View on PubMed ↗ · Free PDF ↗

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Liquid biopsy & cancer biomarker technologies

Spatial habitat radiomics predicts tertiary lymphoid structure status and identifies an IDO1+ migratory dendritic cell axis in breast cancer.

The study developed and validated spatial habitat radiomics using dynamic contrast-enhanced MRI to non-invasively predict tertiary lymphoid structure (TLS) status in breast cancer and to identify associated immune axes. The radiomic TLS signature (shTLS) predicted TLS status across multicenter cohorts and integrated multi-omics analyses to identify an IDO1+ migratory dendritic cell axis linked to TLS biology. This is significant because it provides an imaging-based biomarker for TLS and points to a specific IDO1+ dendritic cell migration program that may influence prognosis and therapeutic response.

Yu Y, Wang Q, Lin Y et al. · Journal for immunotherapy of cancer · (2026) · View on PubMed ↗ · Free PDF ↗

Molecularly Guided Therapy Versus Continued Chemotherapy in Unfavorable Cancer of Unknown Primary: Updated Efficacy and Safety From the Randomized, Phase II CUPISCO Study.

In the randomized phase II CUPISCO trial, patients with previously untreated unfavorable cancer of unknown primary (CUP) who achieved disease control after three cycles of induction chemotherapy were assigned to comprehensive genomic profiling (CGP)-guided molecularly guided therapy (MGT) versus continued platinum-based chemotherapy. With additional follow-up beyond one year, CGP-directed MGT continued to show improved progression-free survival and acceptable safety compared with further chemotherapy. This supports using CGP and molecular tumor board–selected targeted regimens to extend disease control in unfavorable CUP after induction.

Krämer A, Bochtler T, Pauli C et al. · Journal of clinical oncology : official journal of the American Society of Clinical Oncology · (2026) · View on PubMed ↗ · Free PDF ↗

Pan-RAS Inhibitor Shows Activity in Advanced Lung Cancer.

This report studied the first-in-class pan-RAS inhibitor daraxonrasib in patients with previously treated RAS-mutant non-small cell lung cancer (NSCLC). Daraxonrasib shrank tumors in more than 30% of patients, and the results extend prior activity seen in pancreatic cancer where the drug has recently been approved. The findings are significant because they support continued clinical development of daraxonrasib for RAS-driven lung cancer, including an ongoing phase III trial.

Cancer discovery · (2026) · View on PubMed ↗

Implementing liquid biopsy in HR+/HER2- metastatic breast cancer: challenges and opportunities.

This review studied the implementation of liquid biopsy in hormone receptor-positive/HER2-negative (HR+/HER2-) metastatic breast cancer, focusing on circulating tumor DNA (ctDNA) and circulating tumor cells (CTCs) across treatment selection and resistance monitoring. It reports that ctDNA-based detection of actionable mutations including ESR1 and PIK3CA has achieved regulatory validation as a primary predictive biomarker for treatment selection, enabling approvals of endocrine and targeted therapies, and that serial ctDNA monitoring can track resistance. The significance is that liquid biopsy can personalize therapy and improve monitoring in HR+/HER2- metastatic breast cancer by using mutation-informed, longitudinal biomarkers.

Frescura V, Cristofanilli M, Reduzzi C et al. · Current opinion in oncology · (2026) · View on PubMed ↗

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Diabetes, metabolic disease mechanisms & complications

GLP1-RA Use and Risk of Non-arteritic Anterior Ischemic Optic Neuropathy in Patients with Type 2 Diabetes.

This retrospective cohort study using U.S. private-health-plan claims (2012–2024) used target trial emulation to test whether glucagon-like peptide 1 receptor agonist (GLP-1 RA) use is associated with non-arteritic anterior ischemic optic neuropathy (NAION) in adults with type 2 diabetes mellitus (T2DM). The analysis estimated NAION risk while addressing differences in indications and follow-up by emulating a comparative trial design. Clinically, the findings inform cardiovascular/metabolic medication risk–benefit decisions for T2DM patients concerned about NAION.

Lee JJ, Brothers T, Kim LA et al. · Ophthalmology. Retina · (2026) · View on PubMed ↗

(Un)intended consequences of mass-prescribing GLP-1s.

This article reviewed and analyzed the unintended consequences of mass prescribing GLP-1 receptor agonists in the context of global obesity treatment policy. It highlights how GLP-1s have expanded beyond obesity into multiple off-label and public-discourse domains while WHO guidelines aim to ensure fair access for the ~1 billion people affected by obesity. The significance is that evidence-informed stewardship and access frameworks are needed to mitigate downstream clinical, economic, and societal harms as GLP-1 use scales.

Hagenaars LL, Schmidt LA · Science (New York, N.Y.) · (2026) · View on PubMed ↗

Lenacapavir binding to immature Gag induces giant virions and causes protease-dependent inhibition of viral release.

This study examined how the HIV-1 capsid inhibitor lenacapavir (LEN) affects late-stage viral assembly and release in the context of immature HIV-1 Gag. LEN binding to immature Gag induced giant virions and protease-dependent inhibition of viral release, with viral release suppression requiring relatively high LEN concentrations as measured by RT-dPCR and Vpr-HiBiT assays. The work refines understanding of LEN’s stage-specific mechanism and highlights assay interpretation issues (e.g., p24 solubility) relevant for optimizing capsid-targeting therapies.

Amesimeku WAO, Nakata Y, Monde N et al. · Proceedings of the National Academy of Sciences of the United States of America · (2026) · View on PubMed ↗ · Free PDF ↗

Hyperglycemic stress aggravates diabetic retinopathy and nephropathy by promoting cilium disassembly via a deacetylation- and methylation-mediated regulatory mechanism.

This study investigated how hyperglycemic stress worsens diabetic retinopathy and nephropathy by promoting primary cilium disassembly in diabetic mice. Under hyperglycemic conditions, PRMT1 and HDAC6 were upregulated in retinal and renal tissues, and genetic ablation of either enzyme preserved ciliary architecture and restored organ function. The findings identify a deacetylation/methylation regulatory axis (HDAC6/PRMT1) as a mechanistic driver of ciliary loss and a potential therapeutic target for diabetic complications.

Ran J, Wei C, Yang Y et al. · PLoS biology · (2026) · View on PubMed ↗ · Free PDF ↗

Prenatal Water Fluoride Exposure and Children’s Behavioral Problems.

This cohort study used pooled US pregnancy data from the ECHO consortium to examine associations between prenatal exposure to public drinking-water fluoride levels and children’s socioemotional/behavioral problems across ages 1.5 to 17 years. The key finding was the relationship between lower-level prenatal fluoride exposure and later behavioral outcomes (as assessed in the pooled consortium). Clinically, clarifying risk at environmentally relevant fluoride concentrations informs public health guidance on perinatal fluoride exposure and child neurobehavioral safety.

Hernandez A, Nigra AE, Simon KR et al. · JAMA network open · (2026) · 1 citations · View on PubMed ↗ · Free PDF ↗

SGLT Inhibitors for Heart and Kidney Disease in Type 1 Diabetes.

This expert perspective reviewed evidence on sodium-glucose cotransporter (SGLT) inhibitors for heart and kidney disease in people with type 1 diabetes (T1D), contrasting it with the much larger evidence base in type 2 diabetes (T2D) and non-diabetes populations. The key conclusion was that available data are insufficient for definitive T1D-specific efficacy/safety claims, and that mechanistic and clinical evidence gaps must be addressed to support regulatory approval and clinical uptake. Clinically, it frames the research and trial steps needed to determine whether SGLT inhibitors can safely deliver cardiorenal benefits in T1D.

Rosen J, de Boer IH, Eckel RH et al. · Diabetes care · (2026) · View on PubMed ↗

Comparative efficacy and safety of glucagon-like peptide 1 based drugs for weight loss in adults with overweight or obesity without diabetes: network meta-analysis of randomised controlled trials.

This network meta-analysis studied the comparative efficacy and safety of GLP-1–based drugs for weight loss in adults with overweight or obesity without diabetes using randomized controlled trials. Across trials of at least 12 weeks, it compared GLP-1 receptor agonists and related co-agonists against placebo or active comparators, excluding studies enrolling participants with diabetes or unclear diabetes status. The scientific significance is that it provides a ranked, evidence-based estimate of which GLP-1 therapies may offer the best benefit–risk profile for non-diabetic weight management.

Chen D, Ma B, Sun H et al. · BMJ medicine · (2026) · View on PubMed ↗ · Free PDF ↗

Orphan GPCRs in diabetes mellitus: metabolic control, inflammation, and drug development.

This review studied orphan G-protein-coupled receptors (orphan GPCRs) as potential therapeutic targets in diabetes mellitus, focusing on links to metabolic control and inflammation and summarizing drug development status. It classifies orphan GPCRs by functional roles (e.g., insulin secretagogues such as GPR119 and GPR142, among others) and evaluates their mechanistic contributions to diabetic pathology. The significance lies in identifying and organizing emerging GPCR targets that could expand diabetes drug development beyond established pathways.

Chandrabose S, Muniyandi V, Geddawy A et al. · Frontiers in endocrinology · (2026) · View on PubMed ↗ · Free PDF ↗

Postmarketing Safety Signals and Medication-Use Risks of GLP-1-Based Therapies in Diabetes and Obesity: A Multi-Source Pharmacovigilance and Regulatory Evidence-Mapping Study.

This multi-source pharmacovigilance and regulatory evidence-mapping study assessed postmarketing safety signals and medication-use risks for GLP-1 receptor agonists and the GIP/GLP-1 co-agonist tirzepatide in diabetes and obesity using FDA Adverse Event Reporting System (FAERS) data from 2021Q1–2026Q1. The abstract does not include the specific safety signal results, so the key findings cannot be extracted from the provided text. Scientifically, the work aims to clarify real-world risk patterns across semaglutide, tirzepatide, dulaglutide, liraglutide, exenatide, and lixisenatide to support safer prescribing and regulatory monitoring.

Ren L, Zhang Y, Fang F et al. · Diabetes, obesity & metabolism · (2026) · View on PubMed ↗ · Free PDF ↗

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Perioperative monitoring & surgical outcomes

Liposuction versus conservative therapy for patients with lipoedema in Germany: a multicentre, randomised controlled clinical trial.

This multicentre randomized controlled trial in Germany compared liposuction versus conservative complex decongestive therapy for women with stage I–III lipoedema and leg pain. The study tested whether liposuction was superior for clinically meaningful pain reduction while maintaining reasonable safety. The trial provides high-level evidence to guide treatment selection for a chronic, painful condition where conservative therapy often yields limited symptom relief.

Podda M, Schmidt J, Cornely ME et al. · Lancet (London, England) · (2026) · 1 citations · View on PubMed ↗ · Free PDF ↗

Perioperative Hemoglobin Trajectory and Hemoglobin Decrease in Major Abdominal Surgery.

This secondary analysis of the international POSTVenTT prospective multicentre observational cohort studied perioperative hemoglobin trajectories and perioperative hemoglobin decrease in adults undergoing major abdominal surgery. The key finding was that perioperative hemoglobin trajectory/decrease patterns were associated with postoperative outcomes, rather than single time-point hemoglobin measurements capturing risk adequately. Clinically, this supports using longitudinal hemoglobin monitoring to better predict and potentially mitigate postoperative complications in major abdominal surgery patients.

Ripollés-Melchor J, Abad-Motos A, Jericó C et al. · World journal of surgery · (2026) · View on PubMed ↗ · Free PDF ↗

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Mitochondrial function & metabolic flexibility biomarkers

Longitudinal dynamics of gene expression and metabolomics in an aging population cohort.

This longitudinal multiomic cohort study profiled whole-blood gene expression and metabolomics over 8 years in 335 females to characterize spatiotemporal molecular aging dynamics. It found that 5,061 genes and 181 metabolites changed over time, with many individual trajectories diverging from population-level trends and longitudinally variable genes enriched for aging-relevant pathways influenced by genetics, circadian rhythm, seasonality, and environmental pollutants. These results improve understanding of how molecular aging unfolds within individuals and can guide biomarker development that accounts for temporal variability.

El-Sayed Moustafa JS, Ramisch A, Raza YN et al. · Science (New York, N.Y.) · (2026) · View on PubMed ↗

Mitochondrial Respiration in Peripheral Blood Cells Links to Metabolic Flexibility and Physical Performance in Ageing.

This study investigated whether mitochondrial respiratory capacity in peripheral blood mononuclear cells (PBMCs) relates to metabolic flexibility and physical performance in healthy older adults. Using high-resolution respirometry to quantify ROUTINE, LEAK, and MAX states, it found that PBMC mitochondrial respiration capacity was linked to metabolic flexibility and measures of physical performance. This is significant because PBMC bioenergetics could serve as a minimally invasive biomarker for age-related declines in energy metabolism and functional capacity.

Li D, Herpich C, Bishop C et al. · Journal of cachexia, sarcopenia and muscle · (2026) · View on PubMed ↗ · Free PDF ↗

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T cell engineering, receptor biology, and immunotherapy mechanisms

Uneven TCR chain pairing constraints govern epitope recognition.

This study mapped how constraints on T cell receptor (TCR) α/β chain pairing govern epitope recognition by systematically enforcing pairing of individual TCR chains with hundreds of thousands of partners. Although most chains paired stably, preservation of epitope specificity was rare and highly variable (from ~10% to <0.1% compatible partners), and the approach identified >70,000 epitope-specific TCRs across 10 epitopes. These findings show that uneven TCR chain coupling constraints strongly limit specificity, improving prediction and engineering of TCRs for immunotherapies.

Minervina AA, Pogorelyy MV, Mayer-Blackwell K et al. · Science (New York, N.Y.) · (2026) · View on PubMed ↗ · Free PDF ↗

Chimeric HLA Antibody Receptor (CHAR) T Cells to Specifically Eliminate HLA-DQ-Specific B Cells.

This study developed and evaluated chimeric HLA antibody receptor (CHAR) T cells engineered to eliminate HLA-DQ-specific B cells relevant to kidney transplantation. Building on prior HLA class I CHAR T cell work, the authors designed HLA-DQ-targeting CHAR T cells intended to selectively deplete HLA-DQ-reactive B cells in sensitized patients to reduce antibody-mediated rejection risk. The significance is a potential cellular therapy approach to improve outcomes in transplant recipients by directly targeting the dominant HLA-DQ B cell specificity.

Arana C, Gille I, Hagedoorn R et al. · Journal of the American Society of Nephrology : JASN · (2026) · View on PubMed ↗

Bicistronic CD19/CD22 CAR T-Cell Therapy in Pediatric B-Cell Acute Lymphoblastic Leukemia: A Nonrandomized Clinical Trial.

This open-label, multicenter phase 2 nonrandomized trial evaluated bicistronic CD19/CD22 CAR T-cell therapy in pediatric patients with relapsed or refractory B-cell acute lymphoblastic leukemia (B-ALL). The key finding was the therapy’s safety and efficacy profile, targeting two antigens to reduce CD19- or CD22-negative relapse and improve remission durability. Scientifically and clinically, dual-targeting CAR T design may mitigate antigen-loss escape mechanisms that limit durability of single-target CD19 CAR T responses in children.

Wan X, Tang Y, Cai J et al. · JAMA oncology · (2026) · View on PubMed ↗

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Regulatory science & new approach methodologies (NAMs)

Antimicrobial dosing in patients with renal dysfunction.

This review studied contemporary strategies for optimizing antimicrobial dosing in critically ill patients with renal dysfunction, focusing on how altered kidney clearance and extracorporeal circuits affect pharmacokinetics. It highlights that extrapolating dosing from noncritically ill populations can lead to subtherapeutic or toxic exposures and summarizes approaches to improve dosing accuracy in this setting. Clinically, the work is significant because it supports safer, more effective antimicrobial therapy in ICU patients with impaired renal function.

Chai MG, Smareglia LV, Udy AA · Current opinion in critical care · (2026) · View on PubMed ↗

Advances in New Approach Methodologies at FDA’s Division of Applied Regulatory Science.

This mini-review from the FDA Division of Applied Regulatory Science (DARS) evaluated recent advances in New Approach Methodologies (NAMs) for drug development and regulatory decision-making, focusing on in silico and in vitro human-relevant techniques. It highlights quantitative systems pharmacology (QSP) modeling for opioid overdose scenarios, (Q)SAR modeling for toxicity and drug–drug interaction assessment, and multi-omics approaches for pharmacodynamic biomarker discovery, alongside emerging in vitro NAMs. These developments are significant because they aim to improve human relevance and regulatory efficiency while reducing reliance on traditional preclinical models.

Blinova K, Chiu K, Chaturbedi A et al. · Clinical pharmacology and therapeutics · (2026) · View on PubMed ↗ · Free PDF ↗

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Clinical trial endpoints & patient-meaningfulness

Defining Clinically Meaningful Within-Patient Changes in Heart Failure: JACC: Heart Failure Position Statement.

This JACC: Heart Failure position statement studied how to define clinically meaningful within-patient changes for heart failure (HF) trial endpoints beyond mortality, including hospitalizations, imaging/hemodynamics, biomarkers, functional capacity, and patient-reported outcomes. It proposes a pragmatic framework that integrates measurement variability, prognostic associations, and patient-anchored evidence to determine whether statistically significant changes are meaningful for individual patients. This is significant because it standardizes interpretation of HF trial results and improves translation of endpoint changes into patient-relevant clinical benefit.

Yehya A, Hahn R, Borlaug B et al. · JACC. Heart failure · (2026) · View on PubMed ↗

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Generated automatically on September 05, 2026 from PubMed’s trending articles. Summaries are AI-generated; always consult the original publication for clinical or research decisions.