PubMed Trending Research Digest — October 13, 2026

Automated digest · 95 articles · 15 research areas · October 13, 2026

Overview

Across this week’s set, a strong thread is the move from “single-mechanism” thinking toward dynamic, system-level biology that changes over time—whether that’s antifungal susceptibility evolving during treatment (Candida auris), metabolic signaling shifting with exercise and inflammation, or cardiovascular physiology being reinterpreted through metabolic reprogramming and endothelial dysfunction. Several studies also emphasize that risk prediction and clinical decision-making improve when we measure the right signals at the right time: serial antifungal susceptibility in post-surgical fever, hemodynamic phenotyping after non-cardiac surgery, and therapeutic drug monitoring after switching infliximab formulations in IBD.

Another dominant theme is inflammation as a unifying driver across organ systems. Dietary inflammatory potential correlates with continence problems, loneliness/social isolation is framed as a modifiable contributor to cardiovascular risk factors, and multiple respiratory papers highlight anti-inflammatory modulation (montelukast, dupilumab, and NK-cell resolution pathways) as a route to better symptom control and exacerbation prevention. In parallel, mechanistic work links immune activation to tissue remodeling and disease progression—ranging from platelet–immune interactions in cardiometabolic disease to calprotectin-driven vascular calcification in CKD.

Finally, the digest highlights translational momentum: clinical practice guidelines and real-world evidence are being updated to standardize care (renal replacement therapy in critical AKI, tinnitus management, CPAP for OSA), while preclinical and translational studies propose targeted interventions that exploit specific biological “handles” (bile acid/TGR5–GLP-1 signaling, microbiota-linked long COVID phenotypes, and targeted nanomedicine/EV strategies for CNS delivery). Together, these papers reflect a broader shift toward precision—measuring heterogeneity, targeting specific pathways, and integrating mechanistic insight into scalable clinical protocols.

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Antifungal resistance & Candida infections (case reports/biology)

Antiviral immunity via telomerase-like reverse transcription in bacteria.

The study characterized a new bacterial antiviral defense system, DRT10, and its mechanism of telomerase-like reverse transcription templated by a specific noncoding RNA (ncRNA). It found that DRT10 associates with an ncRNA and performs processive, protein-primed synthesis of tandem-repeat DNA, where conserved template boundary elements and sequence patterns are essential for repeat addition, with cryo-EM revealing an unexpected 2:1 RT monomer architecture. Scientifically, this expands the repertoire of defense-associated reverse transcriptases and clarifies how ncRNA-templated repeat DNA synthesis can protect bacteria from viral infection.

Tang S, Ramirez JL, He Q et al. · Nature · (2026) · View on PubMed ↗

Oxidative stress-responsive cell wall remodeling depends on phosphate in Candida albicans.

The study investigated how phosphate availability governs oxidative stress-responsive cell wall remodeling in Candida albicans, using solid-state NMR to probe cell wall structure under conditions mimicking host invasion (phosphate deprivation plus oxidative stress). The key finding was that oxidative stress-driven cell wall remodeling depended on phosphate, linking phosphate homeostasis to how C. albicans adapts its cell wall during invasion. This is significant because it identifies phosphate-dependent remodeling as a potential antifungal vulnerability in invasive candidiasis.

Jacob A, Qi W, Yarava JR et al. · Nature communications · (2026) · View on PubMed ↗ · Free PDF ↗

Early Initiation of Sodium-Glucose Cotransporter 2 Inhibitors in Acute Decompensated Heart Failure: Efficacy, Safety, and Implementation in Stabilized Patients.

This narrative review evaluated early in-hospital initiation of sodium-glucose cotransporter 2 (SGLT2) inhibitors in patients with acute decompensated heart failure (ADHF), particularly in stabilized ICU/CCU settings. The key finding is that early initiation can be feasible and may improve outcomes while maintaining acceptable safety in appropriately stabilized patients, addressing prior concerns about hemodynamic stability and renal function. Clinically, it supports implementation strategies for starting SGLT2 inhibitors during acute hospitalization rather than delaying until after discharge.

Mauriello A, Correra A, Maratea AC et al. · Reviews in cardiovascular medicine · (2026) · View on PubMed ↗ · Free PDF ↗

Postoperative Candida auris Bloodstream Infection Following Cardiac Surgery: Diagnostic Delay and Serial Changes in Azole MIC Values: A Case Report.

This case report studied a 69-year-old man who developed postoperative Candida auris bloodstream infection after modified Morrow surgery and bioprosthetic mitral valve replacement. Serial susceptibility testing showed diagnostic delay and changing azole minimum inhibitory concentration (MIC) values, consistent with azole resistance dynamics in C. auris. The report highlights the need for early C. auris consideration and serial antifungal susceptibility monitoring in post-cardiac-surgery patients with persistent postoperative fever and nonspecific respiratory findings.

Khalid M, Li X, Lei L et al. · Infection and drug resistance · (2026) · View on PubMed ↗ · Free PDF ↗

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Dietary inflammation, lifestyle, and metabolic risk (epidemiology)

Global Incidence of All-Cause Dementia: A Meta-Analysis.

This meta-analysis estimated global incidence of all-cause dementia by age and sex using retrospective community-based cohorts from COSMIC (baseline recruitment 1990–2011) with clinically based dementia diagnoses. The key finding was that dementia incidence estimates remain incomplete due to underrepresentation of low- and middle-income countries and heterogeneity in analytic methods across regions. Clinically, this highlights where improved surveillance and standardized methods are needed to better quantify dementia burden and guide prevention planning worldwide.

Vella AS, Visontay R, Lipnicki DM et al. · JAMA neurology · (2026) · View on PubMed ↗

Estimates of Anxiety Symptoms Among US Adolescents.

This cross-sectional study used the 2024 National Survey on Drug Use and Health to estimate prevalence and severity of anxiety symptoms among US adolescents and to assess associated psychiatric comorbidities and treatment utilization. The key finding was that anxiety symptoms are common in US adolescents and are linked to substantial psychiatric burden, including co-occurring conditions and differences in treatment use. Scientifically and clinically, the results provide updated nationally representative benchmarks to inform screening and resource allocation for adolescent anxiety care.

Bommersbach TJ, Fontanella CA, Olfson M et al. · JAMA pediatrics · (2026) · View on PubMed ↗

Endocrine Disruptors, Gut Microbiota, and Type 2 Diabetes: Bridging Mechanisms to Probiotic-Based Therapeutic Approaches.

This narrative mechanistic review examined how endocrine-disrupting chemicals (EDCs)—including bisphenol A (BPA), phthalates, PFAS, persistent organic pollutants (POPs), and heavy metals—affect gut microbiota and contribute to type 2 diabetes mellitus (T2DM) pathogenesis. It links EDC exposure to insulin resistance, pancreatic β-cell dysfunction, oxidative stress, mitochondrial impairment, chronic inflammation, and epigenetic changes that converge on T2DM development, while proposing probiotic-based therapeutic approaches to bridge these mechanisms. The work supports microbiota-targeted interventions as a potential strategy to mitigate EDC-driven metabolic disease risk.

Cheung SM, Cheng CY, Ponnusamy VK et al. · Diabetes, metabolic syndrome and obesity : targets and therapy · (2026) · View on PubMed ↗ · Free PDF ↗

An ultrasound-responsive hydrogel with piezoelectric-enhanced bioelectric-vesicular coupling alleviates mitochondrial dysfunction and inflammation for osteoarthritis therapy.

The study developed an injectable ultrasound-responsive hydrogel (GM@KP-ABs) for osteoarthritis therapy, incorporating polydopamine-modified potassium sodium niobate nanoparticles (KNN@PDA) and Urolithin A-engineered apoptotic bodies (UA-ABs) to couple ultrasound stimulation with bioelectric signaling. The key reported outcome was alleviation of mitochondrial dysfunction and inflammation, addressing OA’s interconnected inflammatory and cellular-energy dysregulation processes. This provides a multimodal, ultrasound-triggered biomaterial approach that may better coordinate mitochondrial and inflammatory control than either biological therapy or physical stimulation alone.

Zhang Z, Guan X, Zhai Y et al. · Bioactive materials · (2027) · View on PubMed ↗ · Free PDF ↗

Reversal of Chronic Stress-Induced Inflammaging by Bazi Bushen Formula Through AMPK-Sirtuins Axis Activation and Myeloid Reset.

This mouse study tested whether Bazi Bushen Formula reverses chronic stress-induced inflammaging by activating the AMPK–sirtuins axis and resetting myeloid cells. Using a 12-month unpredictable chronic mild stress (UCMS) model, the authors found chronic stress increased systemic inflammation, tissue damage, and shortened lifespan, and single-cell RNA-seq across tissues indicated lymphocyte reduction with myeloid expansion, with lungs and kidneys showing epigenetic dysregulation and mitochondrial dysfunction. The findings support Bazi Bushen Formula as a potential anti-inflammaging intervention targeting AMPK–sirtuin signaling and myeloid immune remodeling under chronic stress.

Li M, Chen Z, Wang L et al. · Exploration (Beijing, China) · (2026) · View on PubMed ↗ · Free PDF ↗

Integrating Artificial Intelligence Competencies Across the Six ACGME Core Competencies: A Proposed Framework for Graduate Medical Education.

This narrative review proposed a framework for integrating artificial intelligence (AI) competencies into the ACGME six core competencies for graduate medical education. It argues that AI-specific competencies are not yet explicitly represented as a distinct domain despite the growing clinical use of FDA-authorized AI medical devices and the expansion of generative AI tools and related regulation. The proposed educational structure is significant for aligning residency training with emerging AI-driven clinical practice and ensuring competency-based adoption.

Kabbash MS, Loftus TJ, Morrow J et al. · Advances in medical education and practice · (2026) · View on PubMed ↗ · Free PDF ↗

The influence of loneliness & social isolation on cardiovascular risk factors: a narrative review.

This narrative review synthesized evidence (2000 to April 2026) on how loneliness and social isolation influence cardiovascular risk factors. It highlights associations between social disconnection and major risk domains such as smoking, stress, dyslipidemia, hypertension, diabetes, and obesity, framing loneliness as a modifiable psychosocial contributor to cardiovascular risk. The review supports incorporating social isolation/loneliness assessment into cardiovascular prevention research and potentially into risk-reduction interventions.

Kaminska M, Gupta K, Lumb A et al. · Expert review of cardiovascular therapy · (2026) · View on PubMed ↗

Hepatic Lipid Stress Drives Metabolic Dysfunction-Associated Steatohepatitis Progression through FTO O-GlcNAcylation-Induced m6A Demethylation of HRAS.

This study investigated how hepatic lipid stress drives progression of metabolic dysfunction–associated steatohepatitis (MASH) through an epigenetic mechanism involving FTO and HRAS. It showed that lipid stress activates the hexosamine biosynthesis pathway, increasing O-GlcNAcylation of the m6A demethylase FTO at Ser195, which recruits USP20, stabilizes FTO, and enhances m6A demethylase activity leading to m6A changes on HRAS. The findings are significant because they connect nutrient-driven post-translational modification (FTO O-GlcNAcylation) to m6A regulation of HRAS, identifying a mechanistic axis potentially targetable to slow MASH progression.

Yin JX, Zhang YL, Liu Q et al. · Advanced science (Weinheim, Baden-Wurttemberg, Germany) · (2026) · View on PubMed ↗ · Free PDF ↗

Vagal sensing of altered gut microbiota links to externalizing behaviors.

This animal study examined how Sirtuin 3 (Sirt3) deficiency alters gut microbiota and gut-brain signaling to influence externalizing behaviors, using Sirt3-knockout (KO) versus wild-type (WT) mice with microbiome controls including cohousing and heterozygous littermates. It reported that altered gut microbiota in Sirt3-KO mice is linked to behavioral differences, supported by transcriptomic profiling of relevant tissues and vagal sensing pathways (as indicated by the study title). The significance is that it strengthens the gut–vagus–brain mechanistic link between host genetics, microbiome changes, and mood/behavior phenotypes.

Lee MJ, Kim IS, Ahn SH et al. · Gut microbes · (2026) · View on PubMed ↗ · Free PDF ↗

Placental TRPV2 supports trophoblast function and normal fetal development.

This study examined the role of the placental ion channel TRPV2 in trophoblast function and fetal development using mouse models. CRISPR/Cas9-mediated Trpv2 deletion in trophoblast stem cells showed that TRPV2 is required for normal placental morphology and trophoblast differentiation toward the syncytiotrophoblast layer, with loss leading to fetal growth restriction and embryonic lethality. The findings are significant because they establish TRPV2 as a non-redundant molecular determinant of placental development and fetal survival.

De Clercq K, Pérez-García V, Panda A et al. · Nature communications · (2026) · View on PubMed ↗ · Free PDF ↗

Atlas of genetic architecture and exploratory temporal interaction networks of plasma protein-based organ and system aging.

The study used plasma proteomic data from 53,014 UK Biobank participants to construct 16 organ- and system-specific plasma-protein aging clocks and to map exploratory temporal interaction networks with environmental exposures and disease associations. The key finding was that the clocks showed thousands of significant associations with 1,059 diseases and widespread responses to 841 environmental factors, with external validation in the China Kadoorie Biobank (n=3,977) supporting robustness and generalizability. Scientifically, this provides a high-resolution, multi-organ framework for quantifying aging biology and linking it to disease risk and environmental influences.

Pu F, Jia X, Hu X et al. · Nature communications · (2026) · View on PubMed ↗ · Free PDF ↗

The Power of Two: Harnessing Dual Glucagon and Incretin Signaling for Treatment of Obesity and Metabolic Dysfunction-Associated Steatohepatitis-A Narrative Review with a Translational Focus.

This narrative review synthesized translational evidence for dual glucagon and incretin signaling approaches to treat obesity and metabolic dysfunction-associated steatohepatitis (MASH), emphasizing the rationale for combining glucagon receptor agonism with GLP-1 receptor activity to counteract glucagon’s hyperglycemic risk. The key finding is that dual agonist strategies can potentially harness glucagon’s energy and liver benefits while leveraging incretin signaling for improved glycemic control and metabolic outcomes. Scientifically and clinically, it frames how “two-receptor” pharmacology may improve efficacy for obesity and MASH beyond single-pathway therapies.

Ard JD, Almandoz JP · Obesity reviews : an official journal of the International Association for the Study of Obesity · (2026) · View on PubMed ↗ · Free PDF ↗

Sputum and oral microbiota profiles are associated with long COVID severity and phenotype post-hospitalisation: a UK multicentre, prospective cohort study.

The study used a UK multicentre prospective cohort (PHOSP-COVID) to relate oral and sputum microbiota profiles measured at 6 months post-discharge to long COVID severity clusters and symptom phenotypes in adults. The key finding was that microbiota composition and co-occurrence network features were associated with long COVID severity/phenotype and with inflammation-related signals, using 16S rRNA gene amplicon sequencing and diversity/network analyses. This is significant because it links persistent airway/oral microbial ecology to long COVID biology and may enable microbiome-informed stratification or interventions.

Alferes de Lima Headley D, Richardson H, Hennayake C et al. · The European respiratory journal · (2026) · View on PubMed ↗

Cell-Free Fetal DNA Testing for Single Gene Conditions (Scientific Impact Paper No. 80).

This BJOG Scientific Impact Paper discusses the clinical application of cell-free fetal DNA testing for single gene conditions, including how pathogenic variants in specific genes can be detected from maternal blood. It outlines the scope of single-gene disorders, inheritance patterns, and how ultrasound anomalies may guide testing decisions. The significance is that it frames how noninvasive prenatal genetic testing could improve diagnosis and counseling for families at risk of monogenic disease.

Mone F, Holder-Espinasse M, Chandler NJ et al. · BJOG : an international journal of obstetrics and gynaecology · (2026) · View on PubMed ↗

Strengthening health systems to prioritise, provide care, and prevent osteoarthritis: a roadmap for global health policy.

This Lancet policy roadmap proposes strengthening health systems to prioritize, provide care, and prevent osteoarthritis (OA) globally, addressing the “OA identity problem” that contributes to stigma, inequities, and low prioritization. It synthesizes evidence on OA’s growing burden and the lack of integrated service models and effective interventions, then translates this into actionable policy directions. Scientifically and clinically, it provides a framework to improve access to OA prevention and management at population scale.

Briggs AM, Bowden JL, Risberg MA et al. · Lancet (London, England) · (2026) · View on PubMed ↗ · Free PDF ↗

Maternal smoking and risk of childhood cancer: a report from the Childhood Cancer and Leukemia International Consortium.

This multinational analysis studied the association between maternal prenatal smoking and childhood cancer using prospectively recorded population-based case-control record-linkage studies from the Childhood Cancer and Leukemia International Consortium. It applied probabilistic bias methods to address biases seen in prior retrospective designs and aimed to clarify whether prenatal tobacco exposure increases childhood cancer risk. The significance is improved causal inference for a modifiable exposure, informing prevention strategies for families and public health guidance.

Domingues A, Spector LG, Tettamanti G et al. · International journal of epidemiology · (2026) · View on PubMed ↗ · Free PDF ↗

Golgi disassembly: a key process for autophagy-mediated regulation of oocyte spindle migration.

This experimental study investigated whether Golgi disassembly occurs during oocyte meiosis and how it regulates spindle migration, using oocyte meiosis I and meiosis II stages. It found that Golgi disassembly exists in oocytes, peaking at germinal vesicle breakdown (GVBD) and largely completing by metaphase II, and that the vesiculation stage specifically governs spindle cortical migration during metaphase I to establish oocyte polarity. The significance is mechanistic insight into autophagy-related and organelle dynamics that control meiotic spindle positioning in reproduction.

Zhang J, Wang N, Wang X et al. · Autophagy · (2026) · View on PubMed ↗

Narrative review: The role of maternal nutrition in recurrent miscarriage: From molecular pathways to clinical care gaps.

This narrative review studied the role of maternal nutrition in recurrent miscarriage (RM), defined as three or more consecutive pregnancy losses before 24 weeks, and synthesized evidence from molecular pathways to clinical care gaps. It highlights that micronutrient status and related placental biology may influence early pregnancy success, despite up to ~50% of RM cases remaining unexplained after standard evaluation. The clinical significance is identifying nutritional assessment and intervention opportunities to address modifiable contributors to RM.

Koroma F, Stone G, Charnock J et al. · Women’s health (London, England) · (2026) · View on PubMed ↗ · Free PDF ↗

Dietary Inflammatory Potential and Continence-Related Symptoms: Cross-Sectional and Longitudinal Analyses of Three Population Studies.

This study analyzed dietary inflammatory potential using the Dietary Inflammatory Index (DII) in adults across three population cohorts (NHANES 2005–2010, English Longitudinal Study of Aging, and Chinese Longitudinal Healthy Longevity Survey 2008–2018) to assess associations with continence-related symptoms. Higher DII scores were linked to greater prevalence and/or progression of continence problems across cross-sectional and longitudinal analyses, with partial harmonization using different DII component versions (25-, 15-component, and a 13-food directional score). These findings suggest that diet-driven inflammation may contribute to urinary and bowel continence impairment and could inform risk stratification or dietary interventions.

Jiang M, Zhong M, Yu J et al. · Food science & nutrition · (2026) · View on PubMed ↗ · Free PDF ↗

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Cardiovascular complications in non-cardiac disease (case reports/diagnostics)

Right Coronary Artery Thrombosis Causing ST-Elevation Myocardial Infarction After a Coronary Artery Disease Reporting and Data System Score of 0, With Disseminated Intravascular Coagulation During Idiopathic Acute Pancreatitis: A Case Report.

This case report studied a 68-year-old man with idiopathic acute pancreatitis who developed ST-elevation myocardial infarction after a coronary artery disease reporting and data system (CAD-RADS) score of 0, complicated by disseminated intravascular coagulation (DIC) during percutaneous coronary intervention. The key finding was right coronary artery thrombosis occurring in a setting where pancreatitis-related electrocardiographic and troponin changes mimicked MI, while DIC created a high-risk balance between bleeding control and prevention of early stent thrombosis. Clinically, it underscores that true coronary thrombosis can occur even with low CAD-RADS scores and that pancreatitis-associated coagulopathy can obscure diagnosis and management.

Chamma AG, Saliba W, Chamma L · Cureus · (2026) · View on PubMed ↗ · Free PDF ↗

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Exercise physiology & metabolic biomarkers in diabetes

Physical Activity, Myokine-Adipokine Signatures and Haemoglobin Glycation Index in Adults with Type 2 Diabetes.

This cross-sectional study examined 185 adults with type 2 diabetes mellitus (T2DM) to determine whether circulating myokines (irisin, myostatin, myonectin, IL-6, IL-15) and adipokines (leptin, adiponectin) are associated with the hemoglobin glycation index (HGI), and whether associations differ by physical activity status and exercise modality. The study found relationships between specific myokine/adipokine profiles and HGI, with effect patterns varying between physically active versus sedentary participants and across exercise modalities. Scientifically, it links exercise-related endocrine signaling to metabolic heterogeneity captured by HGI, supporting more personalized cardiovascular-risk assessment in T2DM.

Ismail M, Ibrahim Hassan M, Shahzoda Fozilovna A et al. · Diabetes, metabolic syndrome and obesity : targets and therapy · (2026) · View on PubMed ↗ · Free PDF ↗

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Herbal medicine & insomnia (reviews)

From Mechanistic Evidence to Clinical Translation: A Narrative Review of Chinese Herbal Medicine for Insomnia.

This narrative review evaluated mechanistic and clinical evidence for Chinese herbal medicine (CHM) in insomnia, synthesizing studies ranging from single herbs/extracts/active constituents to compound formulas using approaches such as multi-omics, network pharmacology, molecular prediction, and experimental validation. The key finding was that while mechanistic evidence exists, clinical trials are often small with inconsistent methodology and limited long-term follow-up, leaving translation to robust clinical practice uncertain. The review emphasizes the need for higher-quality, longer-duration clinical studies and more systematic integration of mechanistic findings to improve CHM insomnia therapy development.

Li X, Xu H, Zhang Y et al. · Drug design, development and therapy · (2026) · View on PubMed ↗ · Free PDF ↗

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Bile acids, gut microbiota, and metabolic regulation (preclinical)

Lactoferrin-modified MSC-derived extracellular vesicles facilitate BBB penetration and enhance gastrodin-induced neuroprotection in Parkinson’s disease: involvement of mitophagy.

This study developed lactoferrin-modified mesenchymal stem cell-derived extracellular vesicles (Lf-EVs) loaded with gastrodin (Gas) to enhance blood–brain barrier penetration and neuroprotection in a Parkinson’s disease model, and it explored involvement of mitophagy. The key finding was that Lf-EVs-Gas improved BBB delivery and enhanced gastrodin-induced neuroprotection compared with controls, with mechanistic data implicating mitophagy pathways. Scientifically and therapeutically, it provides a targeted EV delivery strategy that could overcome a major limitation of gastrodin for Parkinson’s disease treatment.

Luo ZY, Han RJ, Guo TJ et al. · International journal of pharmaceutics: X · (2026) · View on PubMed ↗ · Free PDF ↗

An engineered exosome-based platform for targeted delivery to endogenous neural stem cells and fate modulation after spinal cord injury.

The study engineered TGP1-modified exosomes to target endogenous neural stem cells (eNSCs) and modulate fate after spinal cord injury in vivo. Compared with unmodified exosomes, TGP1-exosomes showed greater injured-spinal-cord accumulation and a 4.6-fold increase in co-localization with Nestin+/SOX2+ eNSC-enriched regions, with Apelin loading used to drive eNSC activation and neuronal differentiation. This suggests a peptide-guided, Apelin-loaded exosome platform as a targeted regenerative strategy for spinal cord injury by steering endogenous stem-cell fate.

Liu Q, Lv A, Lin Y et al. · Materials today. Bio · (2026) · View on PubMed ↗ · Free PDF ↗

ROS-autocatalytic nanoplatform interfering astrocyte-cancer crosstalk and enhancing glioblastoma therapy.

The study developed a dehydroascorbic acid (DHA)-functionalized, ROS-responsive, ferrocene-integrated polymer nanoplatform (GS@DFP) co-loaded with S-Gboxin and Galunisertib to target glioblastoma (GBM) mitochondria and astrocyte-to-cancer mitochondrial transfer. In GBM models, the nanoplatform was designed to cross the blood–brain barrier and disrupt ROS-driven mitochondrial crosstalk while simultaneously inhibiting GBM signaling via Galunisertib, thereby enhancing GBM therapeutic efficacy. This mitochondria- and microenvironment-targeted nanomedicine strategy could improve outcomes in otherwise treatment-resistant GBM by blocking a key metabolic support route (astrocyte–tumor mitochondrial transfer).

Chen Y, Tian Z, Fan H et al. · Nature communications · (2026) · View on PubMed ↗ · Free PDF ↗

A dual-site oral nanovaccine programs anti-colorectal tumor immunity from small intestinal priming to large intestinal boosting.

The study engineered a spatiotemporally programmed dual-site oral nanovaccine (DPML@OVA-CpG) using mesoporous polydopamine nanoparticles stabilized by β-glucan and plant-derived lipids to prime immunity in Peyer’s patches (small intestine) and boost at colorectal tumor sites. The key finding was that sequential immune priming and amplification occurred through a causally linked immune cascade, improving anti-colorectal tumor immunity compared with less coordinated delivery. This approach is significant because it provides mucosal delivery protection and temporal control for oral cancer vaccination, potentially enabling more effective colorectal immunotherapy.

Yang K, Xu H, Liu G et al. · Nature communications · (2026) · View on PubMed ↗ · Free PDF ↗

Combined empagliflozin and liraglutide therapy protects against tacrolimus-induced pancreatic and renal injury associated with oxidative stress reduction.

The study tested whether combined empagliflozin (EMPA, an SGLT2 inhibitor) and liraglutide (LIRA, a GLP-1 receptor agonist) protects male Sprague–Dawley rats from tacrolimus-induced pancreatic and renal injury by reducing oxidative stress, with complementary in vitro and in vivo assessments. The key finding was that tacrolimus caused hyperglycemia, impaired renal function, pancreatic β-cell loss, and renal tubulointerstitial fibrosis, while combined EMPA+LIRA therapy mitigated these injuries through oxidative-stress reduction and improved metabolic and molecular parameters. This is clinically significant because it supports a dual incretin–SGLT2 strategy to reduce tacrolimus nephrotoxicity and pancreatic toxicity.

Na DH, Fang X, Lee H et al. · Kidney research and clinical practice · (2026) · View on PubMed ↗ · Free PDF ↗

Lithocholic Acid Improves Glucose Homeostasis by Activating the TGR5-GLP-1 Axis via Gut Microbiota-Derived Secondary Bile Acids: A Study Done on Diabetic Sprague-Dawley Rats.

This study evaluated lithocholic acid (LCA) in streptozotocin-induced diabetic Sprague-Dawley rats to determine effects on glucose metabolism and underlying mechanisms, with gut microbiota and bile acid metabolomics analyses. LCA improved glucose homeostasis and acted through the TGR5–GLP-1 axis, mediated by gut microbiota-derived secondary bile acids (with ileal transcriptional changes in TGR5 and related bile acid signaling pathways assessed). These findings support a microbiota–bile acid–TGR5/GLP-1 therapeutic strategy for improving glycemic control in diabetes.

Xu C, Yang K, Wu R et al. · Diabetes, metabolic syndrome and obesity : targets and therapy · (2026) · View on PubMed ↗ · Free PDF ↗

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Pediatric airway inflammation therapies (asthma/allergic rhinitis)

Occlusion-Focused Triage vs Very-High-Risk NSTEMI Criteria: A DIFOCCULT-3 Substudy.

This DIFOCCULT-3 substudy compared occlusion-focused triage using the OMI/NOMI framework against guideline-defined very-high-risk NSTEMI criteria for identifying acute coronary occlusion (ACO) in patients presenting with acute coronary syndrome without diagnostic ST-segment elevation. The key result was that OMI/NOMI classification more directly stratified patients for ACO than the very-high-risk NSTEMI criteria, which were inconsistently applied and may miss occlusion cases. Clinically, the work supports adopting an occlusion-focused framework to improve timely invasive management decisions in non–ST-elevation presentations.

Aslanger EK, Aggül B, Yıldırımtürk Ö et al. · JACC. Cardiovascular interventions · (2026) · View on PubMed ↗

Skin-resident CXCR6+ memory CD4+ T cells and dendritic cells form dermal perivascular hubs that drive relapse in allergic dermatitis.

The study examined the role of skin-resident CXCR6+ memory CD4+ T cells and their interactions with dendritic cells in driving relapse across multiple models of allergic dermatitis, including human relevance. It found that CXCR6+ CD4+ TRM cells form dermal perivascular hubs that rapidly induce relapse, maintained in situ by CXCL16-dependent interactions with CD301b+ conventional type 2 dendritic cells, and that blocking CXCL16–CXCR6 signaling impaired CXCR6+ TRM proliferation and maintenance. These results identify a specific CXCR6+ TRM–cDC2 axis as a mechanistic driver and therapeutic target for preventing allergic dermatitis relapse.

Asahina R, Minami F, Nakamizo S et al. · Immunity · (2026) · View on PubMed ↗

Dupilumab Improves Esophageal Distensibility in EoE: 24-Week Results From the REMODEL Randomized Trial.

This phase 4 REMODEL randomized trial evaluated whether dupilumab 300 mg once weekly improves esophageal distensibility in adults with eosinophilic esophagitis (EoE), reporting 24-week outcomes using endoluminal functional lumen imaging probe measurements. The key finding was that dupilumab improved esophageal distensibility versus placebo at week 24, including analyses stratified by baseline distensibility plateau (DP) diameter. This supports dupilumab as an effective disease-modifying therapy for EoE by improving a functional esophageal outcome relevant to narrowing and dysfunction.

Dellon ES, Carlson DA, Greuter T et al. · The American journal of gastroenterology · (2026) · View on PubMed ↗ · Free PDF ↗

Vaccination for girls and women across the life course: Evidence-based recommendations for clinical practice and policy.

This evidence-based recommendations article synthesizes vaccination guidance across the life course for girls and women, addressing key vaccine-preventable diseases (including HPV-related cancers, influenza, pertussis, hepatitis B, herpes zoster, and pneumococcal disease) and special populations such as those in low- and middle-income countries and migrants. The key finding is that multiple life stages (childhood, adolescence, preconception, pregnancy, postpartum, midlife, and beyond) provide critical opportunities to close global coverage gaps beyond the WHO recommendation to complete essential vaccines by adolescence. The clinical significance is improved, actionable policy guidance to reduce preventable morbidity and mortality in women globally.

Divakar H, McAuliffe FM, Goba G et al. · International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · (2026) · View on PubMed ↗ · Free PDF ↗

Effects of Switching From Deucravacitinib to Tildrakizumab in Psoriasis: A 28-Week Real-World Study.

This single-center retrospective real-world study evaluated outcomes in 15 adults with moderate-to-severe psoriasis who switched from the TYK2 inhibitor deucravacitinib to the IL-23p19 antibody tildrakizumab after inadequate response. The key finding was the treatment response and tolerability following the switch at 28 weeks in this deucravacitinib-insufficient responder population. Clinically, the study informs decision-making on sequencing TYK2 inhibition to IL-23p19 blockade when initial therapy is insufficient.

Takahashi Y, Hagino T, Yoneyama M et al. · Journal of psoriasis and psoriatic arthritis · (2026) · View on PubMed ↗

GLP-1-based therapies in lung diseases.

This review summarized evidence that GLP-1 receptor agonists (GLP-1 RAs) have pleiotropic effects relevant to chronic lung diseases beyond glycemic control, including anti-inflammatory and vascular/metabolic actions. The key finding is that GLP-1-based therapies may modulate systemic inflammation and metabolic dysfunction that contribute to conditions such as asthma, COPD, pulmonary hypertension, and interstitial lung disease. This is significant because it supports repurposing or targeting GLP-1 pathways as adjunctive treatments in lung disease management.

O’Callaghan M, Boon MR, Braunstahl GJ et al. · The European respiratory journal · (2026) · View on PubMed ↗ · Free PDF ↗

Dysregulated NK cell phenotype in exacerbation-prone severe asthma.

This study examined circulating natural killer (NK) cell receptor phenotypes, including the specialized pro-resolving mediator (SPM) resolvin D2 (RvD2) receptor DRV2, in severe and non-severe asthma patients from the SARP3 cohort and healthy controls using multiparameter flow cytometry. Exacerbation-prone severe asthma showed dysregulated NK cell phenotypes alongside altered RvD2 and serum amyloid A (SAA) signaling relevant to inflammation resolution. These findings support targeting NK cell dysfunction and RvD2–DRV2 pathways as a potential strategy to improve resolution of airway inflammation and reduce asthma exacerbations.

Duvall MG, Dorazio MH, Chiha T et al. · The European respiratory journal · (2026) · View on PubMed ↗ · Free PDF ↗

ERS/ESRS clinical practice guideline for continuous positive airway pressure for the treatment of adult obstructive sleep apnoea.

This European Respiratory Society/European Sleep Research Society (ERS/ESRS) clinical practice guideline evaluated continuous positive airway pressure (CPAP) versus no or sham treatment across adult obstructive sleep apnoea (OSA) subgroups, focusing on patient-centred and prognostically relevant outcomes. The guideline synthesizes evidence using a PICO framework to determine CPAP’s effectiveness by OSA subtype. Clinically, it provides subgroup-informed recommendations to optimize CPAP use and improve outcomes in adult OSA.

Testelmans D, Schwarz EI, Anttalainen U et al. · The European respiratory journal · (2026) · View on PubMed ↗

The Use of Montelukast in Pediatric Asthma and Anti-Inflammatory Effects - Easy Choice or a Balancing Act?

This article reviewed the use of montelukast, a cysteinyl leukotriene receptor 1 (CysLT1) antagonist, in pediatric asthma and allergic rhinitis with emphasis on anti-inflammatory effects. The key finding is that montelukast can reduce multiple allergic inflammation markers, including fractional exhaled nitric oxide (FeNO), eosinophil counts/mediators, selected cytokines, and airway remodeling–related measures. Clinically, this supports montelukast as an anti-inflammatory option in pediatric airway disease, while highlighting the need to balance benefits against safety considerations.

Adamiec A, Karwowska K, Moliszewska K et al. · Journal of inflammation research · (2026) · View on PubMed ↗ · Free PDF ↗

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Inflammatory bowel disease therapeutics & therapeutic drug monitoring

Toward the next generation of CAR T cell therapies for cancer.

This article reviewed the current clinical experience and next-generation directions for chimeric antigen receptor (CAR) T cell therapies, focusing on how to improve efficacy in solid tumors and reduce manufacturing cost/complexity. The key finding is a synthesis of “three waves” shaping development beyond current commercial products, grounded in lessons from FDA-approved CAR T products and extensive ongoing trials. The review’s significance is that it provides a roadmap for translating clinical lessons into more scalable, effective CAR T designs for broader patient access and improved solid-tumor performance.

Usta D, Mackall CL · Cancer cell · (2026) · View on PubMed ↗

Clinical Course and Predictors of Biologic Therapy, Hospitalisation and Surgery: A Five-Year Prospective Study in Newly Diagnosed Inflammatory Bowel Disease.

This five-year prospective multicenter cohort study in Spain followed 3301 adults with newly diagnosed inflammatory bowel disease (Crohn’s disease, ulcerative colitis, or IBD-U) to identify predictors of biologic therapy use, hospitalization, and surgery. Over the first 5 years after diagnosis, the study characterized clinical course and treatment/hospitalization/surgical outcomes and assessed factors associated with these endpoints. The findings are significant for risk stratification and optimizing long-term management strategies in newly diagnosed IBD patients.

Garre A, Nuñez Ortiz A, Rubio S et al. · Alimentary pharmacology & therapeutics · (2026) · View on PubMed ↗ · Free PDF ↗

Expression patterns of CD24 and CD27 resolve the origins and gradual differentiation of CD11c+ atypical memory B-cells after malaria infection.

This study used high-dimensional flow cytometry, single-cell transcriptomics, V(D)J sequencing, and functional assays to define the origins and differentiation of CD11c+ atypical memory B-cells after malaria infection in human samples. It found that early atypical B-cells (ABCs) expressing CD11c primarily arise from memory B-cells, with intermediate states derived from germinal center-derived and marginal zone-like B-cells. Pseudotime and lineage analyses showed differentiation trajectories marked by progressive loss of CD24 and CD27, clarifying ABC ontogeny and providing markers for tracking differentiation programs.

Courey-Ghaouzi AD, Kleberg L, Mousavian Z et al. · The EMBO journal · (2026) · View on PubMed ↗ · Free PDF ↗

Fecal microbiota transplantation for the decolonization of mucosal adherent-invasive Escherichia coli in Crohn’s disease: an open-label pilot study.

The study evaluated fecal microbiota transplantation (FMT) for decolonizing mucosal adherent-invasive Escherichia coli (AIEC) in 30 adults with Crohn’s disease who were seropositive for serum anti-E. coli antibody (AEcAb), using a single colonoscopic FMT from one of two donors (NCT05611866). The key finding was assessed via changes in mucosal AIEC and fecal/mucosal microbiomes using shotgun metagenomic sequencing and 16S rRNA sequencing, alongside safety outcomes (adverse events within 12 weeks). Clinically, the trial is significant because it tests whether microbiome therapy can specifically clear AIEC at the mucosal niche and reshape microbial communities in Crohn’s disease.

Xu Z, Jiang H, Huang W et al. · Nature communications · (2026) · View on PubMed ↗ · Free PDF ↗

Advances in CAR-T and CAR-NK cell therapy in follicular lymphoma: a review.

This review summarizes advances in CAR-T and CAR-NK cell therapies for follicular lymphoma (FL), emphasizing outcomes in heavily pretreated high-risk populations such as those with POD24, double-refractory disease, histologic transformation, and multiple prior lines. It reports that CD19-directed CAR-T therapies in pivotal single-arm studies achieved high overall response and complete response rates with durable disease control in a subset of patients. The review is significant for informing next-generation cellular immunotherapy development and patient selection in FL.

Yan S, Liu W, Zhou M et al. · Transplantation and cellular therapy · (2026) · View on PubMed ↗ · Free PDF ↗

Accelerated Glofitamab as Urgent Bridging to CAR T-Cell Therapy in High-Risk Relapsed/Refractory Large B-Cell Lymphoma.

This retrospective study evaluated an accelerated glofitamab bridging regimen in adults with high-risk relapsed/refractory large B-cell lymphoma (R/R LBCL) who had plans to proceed to CAR T-cell therapy. It used obinutuzumab 1000 mg on day 1 followed by glofitamab 2.5 mg day 4, 10 mg day 8, and 30 mg day 11, aiming to achieve disease control within days rather than the ~3-week step-up interval. The significance is that faster, step-up–accelerated CD20-directed therapy may reduce time-to-control and improve feasibility of CAR T-cell treatment in urgently progressive patients.

Liu X, Zhang W, Zhang W · Hematological oncology · (2026) · View on PubMed ↗

Infliximab Serum Level Assessment After Switching from Intravenous to Subcutaneous Administration: The ISLASIS Study.

The ISLASIS study prospectively assessed infliximab trough concentrations after switching from intravenous infliximab (IV-IFX) to subcutaneous infliximab (SC-IFX) in adults with Crohn’s disease or ulcerative colitis in Latin America. The key finding was the characterization of how infliximab pharmacokinetics evolve post-switch, including associations between trough levels, biomarkers, and clinical outcomes. This is significant for optimizing maintenance therapy in IBD by informing therapeutic drug monitoring and dosing decisions after route conversion.

Schiavetti BLP, Gasparini RG · Clinical and experimental gastroenterology · (2026) · View on PubMed ↗ · Free PDF ↗

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Skeletal muscle redox/metabolic regulators (mechanistic reviews)

Astrocytic facilitation of somatic NMDARs underpins hippocampal E-S potentiation.

The study examined how astrocytes regulate somatic GluN2B-containing N-methyl-D-aspartate receptors (NMDARs) to support hippocampal EPSP-spike (E-S) potentiation. It found that brief E-S potentiation induction causes sustained calcium activity in nearby astrocytes, requires neuronal soma-localized GluN2B-containing NMDARs, and is promoted by astrocytic vesicular release of D-serine that enhances tonic NMDAR activation. Scientifically, this identifies an astrocyte–D-serine–GluN2B NMDAR mechanism that underpins E-S potentiation and thus hippocampal plasticity.

Dong X, Chen Z, Fu Y et al. · Proceedings of the National Academy of Sciences of the United States of America · (2026) · View on PubMed ↗

Synaptic connectome of a neurosecretory network in the Drosophila brain.

This study mapped the synaptic connectome of neurosecretory cells (NSCs) in the adult Drosophila brain, focusing on pars intercerebralis and pars lateralis NSC classes and their shared upstream inputs. The authors identified neurons providing inputs to multiple NSC classes and found diuretic hormone 44 (DH44)-expressing NSCs as a major coordinator of physiology and behavior. These connectome-level insights clarify how peptide-hormone signaling is integrated across NSC classes to regulate whole-organism behavior in vivo.

McKim TH, Gera J, Gayban AJ et al. · eLife · (2026) · View on PubMed ↗

Integrative ALS therapy: gene targeted therapy by base editing and potential exercise rehabilitation as synergistic strategies for functional recovery.

This integrative ALS therapy concept paper proposes combining TARDBP (TDP-43) base editing–based gene targeting with exercise rehabilitation to improve functional recovery in amyotrophic lateral sclerosis. The key rationale is that base editing could reduce pathogenic TDP-43 proteinopathy and cryptic exon inclusion in STMN2 and UNC13A, while exercise may synergistically enhance functional plasticity. If validated experimentally/clinically, this strategy could provide a combined disease-modifying and rehabilitation-based approach for TARDBP-driven ALS.

Lee K, Kwak T, Park W · Physical activity and nutrition · (2026) · View on PubMed ↗ · Free PDF ↗

Myelin Maintenance and Addition Regulate Synaptic Plasticity in the Adult Mouse Cortex.

This mouse study examined how myelin maintenance and myelin addition regulate synaptic plasticity in adult primary motor cortex by using Plp-CreERT2::Myrffl/fl (disrupting oligodendrocyte/myelin maintenance from P57) and Pdgfrα-CreER::Myrffl/fl (preventing myelin addition) models. Disrupting maintenance impaired action potential conduction and motor performance, while preventing myelin addition altered synaptic properties characterized by increased large, stable mushroom spines and larger miniature excitatory postsynaptic currents despite normal spine density. These findings indicate that adult myelin dynamics actively tune synaptic plasticity and circuit function, with implications for understanding demyelinating disease mechanisms.

Pepper RE, Makowiecki K, Pitman KA et al. · Glia · (2026) · 1 citations · View on PubMed ↗ · Free PDF ↗

Schwann Cell-Specific ATG7-Dependent Autophagy Protects Myelin in a Mouse Model of Krabbe Disease.

This mouse study tested whether Schwann cell–specific ATG7-dependent autophagy protects myelin in Krabbe disease using a Schwann cell–targeted Galc conditional knockout (Galc SC cKO) model. It reported early alterations in autophagy-related proteins and increased autophagosome accumulation in Schwann cells during disease progression, supporting a protective role for ATG7-dependent autophagy in maintaining myelin. These results are significant because they identify autophagy pathways in Schwann cells as potential therapeutic levers for peripheral demyelination in Krabbe disease.

Dhimal N, Sidharth A, Zhang J et al. · Glia · (2026) · View on PubMed ↗ · Free PDF ↗

Sigma-1 Receptor Mitigates Poly-GR-Associated Redox Dysregulation by Restoring NRF2/HO1 Signaling in C9orf72-Associated ALS.

This study examined whether the sigma-1 receptor (Sigma-1R) modulates poly-GR-associated redox dysregulation in cellular and mouse models of C9orf72-associated ALS. In NSC34 cells expressing EGFP-PR42 or EGFP-GR50, poly-GR reduced NRF2 protein levels, and Sigma-1R activation/engagement restored NRF2/HO1 signaling to mitigate oxidative stress phenotypes (abstract truncated). The findings are significant because they suggest Sigma-1R as a potential therapeutic target to preserve antioxidant defenses in C9orf72 ALS driven by dipeptide repeat proteins.

Tsai CY, Wu HC, Su TP et al. · Neuromolecular medicine · (2026) · View on PubMed ↗ · Free PDF ↗

ATAD-3 couples plasma membrane injury to mitochondrial Ca2+ signaling.

This study investigated how ATAD-3 couples plasma membrane injury to mitochondrial Ca2+ signaling in C. elegans. Live imaging and genetic analysis showed delayed mitochondrial Ca2+ influx after injury in mcu-1 mutants, and an RNAi screen identified the conserved AAA+ ATPase ATAD-3 as an essential regulator, while MICU-3 acted as a negative regulator. The work is significant because it reveals a compensatory, ATAD-3-dependent pathway that links membrane damage to mitochondrial Ca2+ uptake and stress responses.

Xu S, Peng Y, Zhou H et al. · Nature communications · (2026) · View on PubMed ↗ · Free PDF ↗

Human testis-specific TTRP regulates circadian clock as an evolutionarily young natural antisense transcript of PER2.

This study characterized TTRP, a human testis-specific TDP-43 pseudogene natural antisense transcript of PER2, and its role in circadian regulation. TTRP interfered with PER2 transcription, encoded a protein that interacted with PER2, BMAL1, and CRY2, and promoted PER2/CRY1 turnover, with gorilla/bonobo TTRP variants altering circadian period and amplitude in human cells. The work is significant because it identifies an evolutionarily young antisense regulator of PER2 that can reshape circadian timing and may contribute to species-specific rhythm differences.

Chen T, Guo L, Zhang H et al. · Nature communications · (2026) · View on PubMed ↗ · Free PDF ↗

The Role of TXNIP in Skeletal Muscle Physiology and Related Diseases: Current Perspectives.

This perspective article synthesized current evidence on thioredoxin-interacting protein (TXNIP) roles in skeletal muscle physiology and diseases, focusing on mechanisms relevant to glucose disposal and muscle disorders. The key finding is that TXNIP functions as a redox and energy-responsive regulator that links metabolic stress to skeletal muscle homeostasis and contributes to conditions such as sarcopenia and obesity-related insulin resistance. Scientifically, it positions TXNIP as a mechanistic node connecting metabolic dysfunction to muscle pathology and as a potential therapeutic target.

Du J, Gao X, Yao S et al. · Journal of inflammation research · (2026) · View on PubMed ↗ · Free PDF ↗

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COPD functional decline & falls risk (systematic review)

Executive Summary of the Clinical Practice Guideline on Tinnitus Update.

This publication provides the executive summary of an updated clinical practice guideline for tinnitus management, targeting clinicians treating adults (≥18 years) with persistent and bothersome tinnitus lasting at least 6 months. The key finding is the guideline’s structured recommendations for evaluation and management of this patient population. Its clinical significance is standardizing care to improve outcomes and quality of life for adults with chronic bothersome tinnitus.

Adams ME, Cramer JD, Tunkel DE et al. · Otolaryngology—head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · (2026) · View on PubMed ↗ · Free PDF ↗

Clinical Practice Guideline: Tinnitus Update.

This publication presents the full clinical practice guideline update for tinnitus, focusing on adults (≥18 years) with persistent and bothersome tinnitus lasting 6 months or longer. The key finding is the guideline’s evidence-based recommendations for clinicians on assessment and management strategies for this defined population. Clinically, it aims to reduce variability in tinnitus care and support interventions that address symptom burden and functional impact.

Adams ME, Cramer JD, Tunkel DE et al. · Otolaryngology—head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · (2026) · View on PubMed ↗

Minimally Invasive Inguinal Hernia Repair in Elderly Patients Over 70 Years: Postoperative Outcomes and Complications.

This retrospective database study compared elective minimally invasive (MIS) inguinal hernia repair outcomes between elderly patients aged ≥70 years (n=57) and younger patients <70 years (n=143) using a prospectively maintained dataset. Elderly patients had different postoperative outcomes/complication rates than younger patients, with the study emphasizing that comorbidities and anesthetic risk did not preclude MIS in this cohort. These findings support the feasibility and risk stratification of MIS inguinal hernia repair in patients over 70 years, informing surgical decision-making in an aging population.

Claus CMP, Ruggeri JRB, Nezo VHS et al. · Journal of laparoendoscopic & advanced surgical techniques. Part A · (2026) · View on PubMed ↗

Mid-term clinical outcomes of one and two patient-specific mini-implants for focal (osteo-)chondral lesions of the distal femur.

This retrospective single-center study evaluated mid-term clinical outcomes of patient-specific mini-metal implants (Episealer® Implant, Episurf) for focal (osteo-)chondral lesions of the distal femur, including one-implant and two-implant approaches in the same knee. Patients receiving one or two mini-implants showed clinical performance outcomes over follow-up, supporting feasibility of both single- and dual-lesion implant strategies. The findings are clinically relevant for middle-aged patients with focal distal femoral cartilage defects when biological repair is unlikely to succeed.

Rüter ML, Kösters C, den Toom DA · Journal of ISAKOS : joint disorders & orthopaedic sports medicine · (2026) · View on PubMed ↗

Reference frame for Adult Brainstem gliomas.

This article studied how to establish a reference frame for adult brainstem gliomas (BSG) to standardize neurosurgical decision-making and tissue sampling in adults with rare BSG (<2% of gliomas). It reports that each case should be evaluated by specialized neurosurgeons to choose among stereotactic biopsy, open biopsy, or tumor resection, with the main goal of enabling histomolecular analyses to confirm diagnosis and subtype. The scientific significance is improved diagnostic accuracy and more consistent surgical planning for adult BSG, supporting better downstream molecular classification and management.

Laigle-Donadey F, Mesny E, Bielle F et al. · The oncologist · (2026) · View on PubMed ↗ · Free PDF ↗

Neuromuscular, Balance, and Gait Factors Associated with Falls and Fall-Related Outcomes in Individuals with COPD: A Systematic Review.

This systematic review examined neuromuscular, balance, and gait factors associated with falls and fall-related outcomes in individuals with COPD by synthesizing evidence from studies published up to November 2024. The key finding is that impairments in muscle strength, balance, and gait are consistently implicated in increased fall risk and related adverse outcomes in COPD populations. This is clinically significant because it supports targeted fall-risk assessment and rehabilitation strategies beyond general deconditioning.

Zangi M, Shamsi H, Rahmani Rasa A et al. · International journal of chronic obstructive pulmonary disease · (2026) · View on PubMed ↗ · Free PDF ↗

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Emergency hemostasis & trauma care (case reports)

Randomized Trial of Hypofractionated Postmastectomy Radiation Therapy in Women With Breast Reconstruction (RT CHARM, Alliance A221505).

This randomized noninferiority trial (RT CHARM, Alliance A221505) studied hypofractionated versus conventional postmastectomy radiation therapy (PMRT) in women with breast cancer undergoing immediate breast reconstruction. The primary outcome was the reconstruction complication rate (composite of wound healing, readmission, capsular contracture, unplanned reoperation, and reconstruction failure), and the trial was designed to test whether hypofractionated PMRT is not worse than conventional PMRT. If noninferiority is demonstrated, the findings would support shorter-course PMRT to reduce barriers to reconstruction while maintaining acceptable safety.

Poppe MM, Le-Rademacher JJ, Haffty BG et al. · Journal of clinical oncology : official journal of the American Society of Clinical Oncology · (2026) · View on PubMed ↗

Emerging novel therapies for the treatment of hereditary haemorrhagic telangiectasia.

This article reviews emerging novel therapies for hereditary haemorrhagic telangiectasia (HHT), an autosomal dominant angiogenic signalling disorder affecting patients worldwide, with particular emphasis on women’s morbidity. It highlights that HHT complications—especially chronic epistaxis, gastrointestinal bleeding with iron deficiency anemia, and high-risk intracranial hemorrhage—drive the need for targeted anti-angiogenic and other mechanism-based treatments. The clinical significance is that consolidating the evolving therapeutic landscape can guide selection of newer interventions to reduce bleeding burden and prevent life-threatening vascular complications in HHT.

Al-Samkari H · The Lancet. Haematology · (2026) · View on PubMed ↗ · Free PDF ↗

Hemorrhage Control in a Facial Gunshot Wound: A Case Report.

This case report described hemorrhage control in a 74-year-old man with a facial gunshot wound to the submandibular region, with suspected apixaban (Eliquis) overdose and concurrent alprazolam (Xanax) use. The key finding was that deployment of a hemostatic gel (Traumagel) into the complex wound achieved bleeding control when traditional methods failed. The report is significant as an emergency-care example of hemostatic gel use for difficult facial hemorrhage in an anticoagulated patient.

Knobl TR, Carruth TN · Open access emergency medicine : OAEM · (2026) · View on PubMed ↗ · Free PDF ↗

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Critical care renal replacement therapy guidelines

Postoperative Vasoactive Exposure Patterns and Outcomes After Non-Cardiac Surgery: A Prespecified Analysis of the SQUEEZE Cohort.

This prespecified analysis of the international SQUEEZE cohort studied adults undergoing non-cardiac surgery who received postoperative vasoactive infusions within 7 days, using unsupervised k-means clustering based on duration of vasoactive infusion, cumulative vasoactive agent-days, and peak concurrent vasoactive agents. The study found that reproducible postoperative vasoactive exposure patterns provide prognostic information beyond simple duration metrics. Clinically, this supports more nuanced hemodynamic phenotyping after surgery to better predict outcomes and potentially guide postoperative management.

Ripollés-Melchor J, Jammer I, Creagh-Brown B et al. · Acta anaesthesiologica Scandinavica · (2026) · View on PubMed ↗ · Free PDF ↗

Pregnancy Complicated by Citrin Deficiency and Gestational Diabetes Mellitus: Perioperative Metabolic Management and Postoperative Analgesic Challenges Following Caesarean Delivery.

This case report studied perioperative metabolic management and postoperative analgesic challenges in a 25-year-old woman with genetically confirmed citrin deficiency due to an SLC25A13 c.1763G>A homozygous mutation complicated by gestational diabetes mellitus (GDM) undergoing caesarean delivery. It describes coordinated obstetric and inherited metabolic disease team management addressing severe first-trimester nausea/vomiting and GDM diagnosed via capillary glucose monitoring. The clinical significance is practical guidance for anesthetic/analgesic and metabolic planning in rare SLC25A13-related citrin deficiency during pregnancy and delivery.

Naing EEP, Kyaw EMM · Cureus · (2026) · View on PubMed ↗ · Free PDF ↗

Clinical practice guideline for renal replacement therapy in critically ill patients with acute kidney injury (2026 edition).

This 2026 Chinese clinical practice guideline was developed for renal replacement therapy (RRT) in critically ill patients with acute kidney injury (AKI), using a GRADE-based multidisciplinary expert panel process. The key finding is the establishment of unified recommendations addressing core RRT decisions, including timing of initiation, modality selection, anticoagulation strategy, and weaning from RRT. This is significant because it standardizes care to reduce variability and improve outcomes in critically ill AKI patients.

Kang Y, Guan X, Chen D · Journal of intensive medicine · (2026) · View on PubMed ↗ · Free PDF ↗

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Endothelial dysfunction & metabolic reprogramming in CVD (reviews)

Micronuclear ecDNA constrains tumor cell fitness and is associated with favorable patient survival.

The study investigated how extrachromosomal DNA (ecDNA) damage, mitotic segregation, and micronuclei (MN) formation affect tumor cell fitness and patient outcomes in chromosomally unstable cancers. It found that replication stress drives ecDNA clustering and mis-segregation into MNs, and single-micronucleus sequencing showed multiple distinct ecDNA species coalescing within individual MNs, with MN-associated transcriptional reduction linked to favorable survival. These findings suggest MN formation can constrain ecDNA-driven tumor evolution and may serve as a prognostic biomarker or mechanistic vulnerability in ecDNA-positive cancers.

Brückner L, Xu R, Tang J et al. · Nature genetics · (2026) · View on PubMed ↗

Cardiovascular Complications of Chronic Liver Disease.

This state-of-the-art review summarized evidence on cardiovascular complications in chronic liver disease, focusing on bidirectional liver–heart interactions and shared mechanisms. The key finding is that cardiovascular disease risk and outcomes are strongly shaped by chronic liver disease through mechanisms such as inflammation and systemic dysregulation, yet are often underrecognized in clinical care. The significance is that it provides a framework for improving cardiovascular risk assessment and integrated hepatology–cardiology management in patients with liver disease.

Park S, Gupta DK, Izzy M et al. · Circulation · (2026) · View on PubMed ↗

EpCAM-dependent membrane mechanics regulate nuclear deformation and promote gastric cancer metastasis.

The study investigated how EpCAM-dependent membrane mechanics regulate nuclear deformation and promote gastric cancer metastasis. It found that EpCAM overexpression reduces apparent plasma membrane tension, remodels ERM–actin, increases traction forces, and enhances nuclear deformation during confined migration, while EpCAM knockout or monoclonal antibody blockade reduced invasion and lymph node dissemination in vivo; mechanistic perturbation of ezrin and lamin A/C supported a membrane–cytoskeleton–nucleus coupling model. These results identify EpCAM as a regulator of metastatic biomechanics and suggest EpCAM targeting as a potential anti-metastatic strategy in diffuse gastric cancer.

Chen G, Jiang M, Yang J et al. · Cell reports · (2026) · View on PubMed ↗

Physically interacting immune cells in cardiometabolic disease: established platelet-immune aggregates and emerging leukocyte-leukocyte complexes.

This review article examined evidence for direct physical interactions between immune cells in cardiometabolic disease, emphasizing platelet–immune cell aggregates and emerging leukocyte–leukocyte conjugates detected in blood or dissociated samples. The key finding is that while many dual-lineage flow-cytometric events can be technical doublets, a validated subset represents true cell-cell conjugates rather than antibody–antigen complexes. Scientifically, it frames how these conjugates may serve as biomarkers of immune activation and platelet involvement, motivating more rigorous detection and interpretation in cardiometabolic research.

Mwesigwa N, Kirabo A, Wanjalla CN · Cardiovascular research · (2026) · View on PubMed ↗ · Free PDF ↗

Calprotectin Accelerates Pathogenic Calciprotein Particle Maturation to Promote Vascular Calcification in Chronic Kidney Disease.

This preclinical study investigated how calprotectin (CPT; S100A8/A9) accelerates maturation of secondary calciprotein particles (CPP2) to promote vascular calcification in chronic kidney disease (CKD) using CKD-mineral and bone disorder mouse models. The key finding was that CPT promotes pathogenic CPP2 maturation and thereby enhances vascular calcification under CKD-relevant conditions. Clinically, it identifies CPT as a mechanistic driver and potential therapeutic target to reduce cardiovascular calcification risk in CKD.

Zhang J, Kanki T, Tsushida M et al. · Circulation research · (2026) · View on PubMed ↗

Development of a GPCR-binding ligand screening method using real-time interaction analysis on live cells.

The study developed a GPCR-binding ligand screening method using real-time interaction analysis on live cells, focusing on the neurokinin 1 receptor (NK1-R) to identify high-affinity ligands for theranostic applications. Using time-resolved live-cell competition with fluorescently labeled endogenous ligand (with 60 iodine-containing synthesized ligands enabling radiolabeling via isotopic exchange), the assay was designed to capture ligand-induced GPCR conformational state changes. This provides a platform for efficiently discovering NK1-R binders suitable for imaging and radiotherapeutic development.

Westin H, Yushchyshyna H, Vorontsova O et al. · Biochemistry and biophysics reports · (2026) · View on PubMed ↗ · Free PDF ↗

PLPP1 inhibits Wnt/β-catenin signaling via enhancing Caveolin-1/β-catenin interaction and is negatively regulated by c-Myc in osteosarcoma.

This study investigated the role of phospholipid phosphatase 1 (PLPP1) in osteosarcoma by testing how PLPP1 affects Wnt/β-catenin signaling through caveolin-1/β-catenin interactions and whether c-Myc regulates PLPP1. Using analyses of TARGET-OS and GEO datasets plus qRT-PCR, Western blotting, and immunohistochemistry in osteosarcoma cells and samples, the authors reported that PLPP1 inhibits Wnt/β-catenin signaling and is negatively regulated by c-Myc. The results suggest a mechanistic tumor-suppressive pathway in osteosarcoma that could be leveraged for targeted therapeutic strategies.

Nie J, Zhou Y, Xie X et al. · Journal of orthopaedic translation · (2026) · View on PubMed ↗ · Free PDF ↗

Spatial Atlas of Small Cell Lung Carcinoma Reveals Intratumoral Tumor-State Heterogeneity and an MMP12+ Macrophage Niche.

This study analyzed 16 small-cell lung carcinomas (plus one atypical case) using in situ hybridization-based spatial transcriptomics integrated with histology and protein-expression profiling to map intratumoral heterogeneity and microenvironmental niches. It identified an MMP12+ macrophage niche associated with spatial tumor-state heterogeneity across SCLC specimens. The work is significant because it links specific spatial immune microenvironments to SCLC subtype biology (ASCL1/NEUROD1/POU2F3/YAP) that may underlie treatment resistance and guide niche-targeted therapies.

Nomura N, Jimbo N, Nakanishi T et al. · Cancer science · (2026) · View on PubMed ↗ · Free PDF ↗

Nutrient Sensing and Growth Control in Plasmodium: Beyond mTOR Signaling.

This review article examined how Plasmodium malaria parasites coordinate nutrient sensing and growth control despite lacking canonical mTOR kinase orthologues. It summarizes evidence that Plasmodium uses a distributed, parasite-specific regulatory architecture involving nutrient sensors and kinase-based signaling pathways rather than the typical mTOR complex system. The significance is that it reframes nutrient-growth regulation in malaria and highlights potential parasite-specific targets for antimalarial intervention.

Müller F, Pradel G · Molecular microbiology · (2026) · View on PubMed ↗ · Free PDF ↗

A Dual-Delivery System Designed to Overcome EV-Mediated Ferroptosis Resistance for Efficient Solid Tumor Therapy.

This solid-tumor therapy study investigated how osteosarcoma (OS)–derived extracellular vesicles (EVs) mediate ferroptosis resistance and developed a dual-delivery approach to overcome it. It found that OS EVs enriched with ENO1 enhance antioxidant capacity and confer ferroptosis resistance to macrophages and neutrophils, creating an immunosuppressive niche, and that an OS-targeting lipid nanoparticle (LNP) delivering BAP1 mRNA together with ENO1 can disrupt this defense. The work is significant because it couples EV biology (ENO1-mediated resistance) with a targeted nucleic-acid delivery strategy to improve ferroptosis-based solid tumor therapy.

Shen Y, Cao Z, Wang Z et al. · Advanced science (Weinheim, Baden-Wurttemberg, Germany) · (2026) · View on PubMed ↗ · Free PDF ↗

Lactylation-Mediated HER2 Stabilization Promotes Trastuzumab Resistance in Gastric Cancer.

This study examined how AARS1-mediated lactylation of HER2 affects trastuzumab response in HER2-positive gastric cancer cells and models. Lactylation at HER2 lysine 1171 (K1171) promoted USP11-mediated deubiquitination and stabilization of HER2, thereby driving trastuzumab resistance. These findings identify a lactylation–HER2 stabilization axis as a potential therapeutic target to overcome trastuzumab resistance in gastric cancer.

Qian M, Tian T, Wang Z et al. · Advanced science (Weinheim, Baden-Wurttemberg, Germany) · (2026) · View on PubMed ↗ · Free PDF ↗

ApoE lipidation state directs immunometabolic reprogramming of human microglia.

This study investigated how ApoE lipidation state (lipid-free vs lipid-bound ApoE3 or ApoE4) reprograms human microglial immunometabolism. ApoE4 exposure produced fewer but enlarged lipid droplets and increased mitochondrial fragmentation, with proteomic and phenotype changes consistent with ApoE-lipidation–dependent microglial dysfunction. The results are significant because they mechanistically link the ApoE ε4 risk allele to microglial metabolic remodeling that may contribute to Alzheimer’s disease pathogenesis.

Shiferaw TG, Sarkar S, Baker KM et al. · Alzheimer’s & dementia : the journal of the Alzheimer’s Association · (2026) · View on PubMed ↗ · Free PDF ↗

Low-Density Lipoprotein Receptor-Targeted Biomimetic Nanoplatform Suppresses Glioblastoma Stemness and Remodels Antitumor Immunity via Dual Metabolic Disruption.

This research tested a low-density lipoprotein receptor (LDLR)-targeted biomimetic nanoparticle platform delivering regorafenib plus erythrodiol (ApoBf-R/E@NPs) in glioblastoma models, focusing on glioblastoma stemness and antitumor immunity. The fixed-ratio combination showed synergy, with regorafenib disrupting autophagy-associated nutrient salvage and angiogenic support while erythrodiol stabilized the antitumor immune microenvironment and reduced stem-like properties (details truncated). Scientifically, it supports a dual metabolic disruption strategy to improve brain-tumor drug delivery and suppress glioblastoma stemness via immune remodeling.

Jiang Y, Yang W, Cheng W et al. · Advanced science (Weinheim, Baden-Wurttemberg, Germany) · (2026) · View on PubMed ↗ · Free PDF ↗

Targeting receptor tyrosine kinases: from molecular mechanisms to clinical therapeutics.

This article reviewed receptor tyrosine kinase (RTK) signaling mechanisms and their integration with major pathways including G protein-coupled receptors, Wnt, and transforming growth factor-β, focusing on implications for cancer therapeutics. The key finding is a synthesis of how RTK pathway components and cross-talk drive disease progression and how these mechanistic insights translate into clinical targeting strategies. This is significant for guiding rational development and selection of RTK-directed therapies across cancers and related RTK-driven disorders.

Wu K, Ji J, Sun T et al. · Signal transduction and targeted therapy · (2026) · View on PubMed ↗ · Free PDF ↗

Hepatic retromer is essential for systemic cholesterol homeostasis by regulating lysosomal cholesterol handling.

This mechanistic mouse study investigated the role of hepatic retromer, specifically the vacuolar protein sorting 35 (VPS35) component, in lysosomal cholesterol handling and systemic cholesterol homeostasis using liver-specific VPS35 ablation. Loss of hepatic VPS35 increased plasma and hepatic cholesterol by impairing hepatic uptake of atherogenic lipoproteins and disrupting lysosomal cholesterol trafficking. Scientifically, it identifies VPS35 as a critical regulator of cholesterol homeostasis, suggesting a potential therapeutic target for atherosclerotic cardiovascular disease and MASLD.

Verzijl CRC, Barbosa MG, Vos DY et al. · Molecular metabolism · (2026) · View on PubMed ↗ · Free PDF ↗

Blockade of mutant RAS oncogenic signaling: a 2026 update.

This 2026 update reviewed how blocking mutant RAS oncogenic signaling affects downstream pathways, focusing on RAS proteins (HRAS, KRAS, NRAS) and their regulation by GEFs and GAPs within the RAS–RAF–MEK–ERK and PI3K–AKT cascades. It summarizes current and emerging strategies to inhibit mutant RAS-driven signaling, particularly in KRAS-mutant cancers that comprise the majority of RAS-mutant tumors. The review is significant for guiding ongoing drug-development efforts aimed at improving targeted therapy for RAS-driven malignancies.

Roskoski R · Pharmacological research · (2026) · View on PubMed ↗ · Free PDF ↗

Revisiting Cell Death in Colorectal Cancer: The Rise of Ferroptosis as a Therapeutic Opportunity.

This narrative review revisited cell death mechanisms in colorectal cancer (CRC), focusing on ferroptosis as a therapeutic strategy to overcome apoptosis-dependent resistance. It describes how CRC resistance can involve p53 alterations, BCL-2 upregulation, and drug efflux, and it emphasizes ferroptosis pathways such as GPX4 blockade, iron dysregulation, and lipid metabolism remodeling. The scientific significance is that targeting ferroptosis may provide a route to treat drug-resistant CRC when conventional apoptosis-based therapies fail.

Altamimi AO, Elemam NM, Kalady MF et al. · Journal of cellular physiology · (2026) · View on PubMed ↗

Endothelial Dysfunction and Metabolic Reprogramming in Cardiovascular Diseases.

This review article summarized how endothelial dysfunction is driven by metabolic reprogramming in cardiovascular diseases, focusing on shifts among glycolysis, fatty acid oxidation, and amino acid metabolism. The key finding is that metabolic changes reduce nitric oxide (NO), increase oxidative stress and inflammation, and weaken vascular barrier integrity, thereby accelerating atherosclerosis and related vascular pathologies. Scientifically, it links endothelial metabolic pathways to disease mechanisms and highlights potential metabolic targets for therapy.

Chen H, Zhao Y, Ge C et al. · Reviews in cardiovascular medicine · (2026) · View on PubMed ↗ · Free PDF ↗

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Lipoprotein(a) biology & Lp(a)-lowering strategies (reviews)

Lipoprotein(a) Inhibition: Current Evidence, Therapeutic Landscape, and Future Directions.

This review assessed lipoprotein(a) [Lp(a)] inhibition by summarizing genetic/causal evidence, current therapeutic approaches, and future directions for reducing Lp(a)-mediated cardiovascular risk. The key finding is that Lp(a) is largely genetically determined and only modestly responsive to lifestyle and conventional lipid-lowering therapies, making Lp(a)-targeted treatments important for residual risk reduction. This is significant for guiding development and clinical adoption of therapies aimed at lowering Lp(a) to prevent atherosclerotic cardiovascular disease and calcific aortic valve disease.

Sabouret P, Giamundo DM, Popiolek-Kalisz J et al. · Reviews in cardiovascular medicine · (2026) · View on PubMed ↗ · Free PDF ↗

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Acute heart failure therapies & pharmacologic initiation (trials/real-world)

Sustained type I interferon activity and N-antigenemia form a vicious cycle during severe COVID-19.

The study investigated SARS-CoV-2 nucleocapsid (N)-antigenemia kinetics and host/viral determinants of viral dissemination in severe COVID-19 using three independent hospital cohorts. It found that sustained type I interferon activity and N-antigenemia reinforce each other in a vicious cycle, and that these dynamics were associated with risk of death. Clinically, the results implicate interferon-driven antigenemia as a mechanistic contributor to severe disease progression and a potential target for risk stratification or therapeutic intervention.

Mouton W, Saker K, Franc P et al. · EBioMedicine · (2026) · View on PubMed ↗

Clinical outcomes of sacubitril/valsartan in patients with mildly reduced or preserved ejection fraction and acute heart failure: a multi-institutional study.

This multi-institutional real-world study evaluated clinical outcomes and safety of in-hospital initiation of sacubitril/valsartan in 9,107 patients hospitalized for acute heart failure with mildly reduced or preserved ejection fraction (HFmrEF/HFpEF), including subgroups with advanced chronic kidney disease or dialysis. Using propensity score weighting, the authors assessed comparative outcomes between sacubitril/valsartan and alternative management strategies (details truncated in the abstract). The work is clinically significant because it extends evidence for sacubitril/valsartan to underrepresented HFmrEF/HFpEF populations with renal impairment in routine practice.

Huang B, Chen CC, Tsai ML et al. · Annals of medicine · (2026) · View on PubMed ↗ · Free PDF ↗

COVID-19 triggers pulmonary tumor outgrowth through hypoxia- and inflammation-induced VEGF-dependent angiogenesis.

This study tested whether SARS-CoV-2 infection can trigger outgrowth of dormant pulmonary tumors by activating a VEGF-dependent angiogenic switch driven by hypoxia and inflammation. Using animal models, the authors reported that SARS-CoV-2 infection induced profound pulmonary hypoxia and severe tissue inflammation, which promoted angiogenesis and tumor outgrowth (details truncated). The findings are clinically important because they suggest a mechanistic link between COVID-19–associated lung pathology and reactivation/progression of dormant cancer lesions.

Jing X, Ma M, Bai Y et al. · Signal transduction and targeted therapy · (2026) · View on PubMed ↗ · Free PDF ↗

Continuous Vutrisiran Reduces Cardiovascular Events and Hospitalizations in Patients With Transthyretin Amyloidosis With Cardiomyopathy in the HELIOS-B One-Year Open Label Extension.

This open-label extension analysis of the HELIOS-B trial assessed long-term effects of continuous vutrisiran therapy on cardiovascular (CV) hospitalizations and urgent heart failure (HF) visits in patients with transthyretin amyloidosis with cardiomyopathy (ATTR-CM). Continuous vutrisiran reduced hospitalization and urgent HF events compared with the prior placebo-controlled period, extending the benefits observed in the phase 3 HELIOS-B study. These results support sustained clinical benefit of the RNA-silencing drug vutrisiran in ATTR-CM, with implications for long-term disease management and healthcare utilization.

Cuddy SAM, Griffin JM, Tang WHW et al. · Journal of cardiac failure · (2026) · View on PubMed ↗ · Free PDF ↗

Pulsed field ablation with Renal denervation for persistent Atrial fibrIllation: Rationale and design of the PRAISE-AF randomized trial.

This paper describes the rationale and design of the PRAISE-AF randomized trial evaluating pulsed field ablation (PFA) combined with renal denervation (RDN) for persistent atrial fibrillation (AF). The study is designed to test whether the nonthermal, myocardial-selective PFA approach plus sympathetic modulation via RDN improves outcomes compared with an appropriate control strategy in persistent AF patients. If successful, it could establish a safer and more effective rhythm-control pathway for persistent AF by combining two mechanistically complementary interventions.

Guo J, Qin M, Jiang W et al. · American heart journal · (2026) · View on PubMed ↗

Prominent V Waves Augment Right Ventricular Afterload Independent of the Lung Vessels in Heart Failure: Implications for Clinical Assessment of Pulmonary Vascular Disease.

This retrospective cohort study examined heart failure with preserved ejection fraction (HFpEF) patients undergoing invasive hemodynamic exercise testing to characterize prominent left atrial (LA) V waves as a marker of LA stiffening. It found that heightened LA stiffening—operationalized as pulmonary artery wedge pressure (PAWP) V wave exceeding mean PAWP by ≥10 mmHg—augmented right ventricular afterload independent of lung vessels. Clinically, this supports using V-wave–based hemodynamic definitions to better assess pulmonary vascular disease physiology in HFpEF.

Chaikijurajai T, Reddy YNV, Harada T et al. · Circulation · (2026) · View on PubMed ↗

Safety and Efficacy of Asundexian in Cardiovascular Diseases, Updated Systemic Review and Meta Analysis.

This updated systematic review and meta-analysis studied asundexian, an oral factor XIa inhibitor, across randomized controlled trials in patients with atrial fibrillation (AF), acute myocardial infarction, or stroke. It pooled five RCTs (n=31,301) comparing asundexian 50 mg daily versus placebo or apixaban and assessed outcomes including all-cause mortality and ischemic stroke/systemic embolism. The significance is that integrating the OCEANIC-STROKE trial evidence clarifies the balance of thromboembolic prevention versus bleeding risk for factor XIa inhibition in cardiovascular disease.

Siddiqui E, Ahmad N, Majid S et al. · Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis · (2026) · View on PubMed ↗ · Free PDF ↗

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Generated automatically on October 13, 2026 from PubMed’s trending articles. Summaries are AI-generated; always consult the original publication for clinical or research decisions.