PubMed Trending Research Digest — October 14, 2026

Automated digest · 98 articles · 15 research areas · October 14, 2026

Overview

Across this week’s set of papers, a dominant theme is “precision” across systems: from molecular mechanisms (e.g., splicing recursion in CADM2, mechanobiology via EpCAM, and ecDNA-driven amplification) to translational tools (e.g., standardized functional assays for BRCA VUS, enhancer–promoter interaction mapping, and AI/MRI screening generalization). Cancer research particularly emphasizes actionable targets and improved stratification—whether through immunotherapy optimization (prophylactic steroids for CAR T toxicity, CAR NK mRNA delivery, perioperative immunotherapy meta-analyses) or through better biomarkers and patient-selection frameworks (spatial ADC target mapping, HRR testing implementation gaps, and gene-informed DCM arrhythmia risk).

A second major thread links inflammation and tissue remodeling to disease progression and complications. Examples span cardiovascular–liver and cardiorenal risk in chronic disease, TGFβ2–SPARC signaling bridging heart failure to neurocognitive decline, and multiple immune–tissue interfaces (microglia–endothelial crosstalk, context-dependent TREM2 signaling, CXCR6+ TRM hubs in allergic dermatitis relapse, and MDA5’s role in extracellular RNA clearance protecting against lung fibrosis). In parallel, several studies focus on host–pathogen or immune dynamics—such as severe COVID-19 interferon–antigenemia “vicious cycles,” malaria anemia mechanisms, and lung immune responses to multidrug-resistant Klebsiella—reinforcing that immune state and microenvironment strongly shape outcomes.

Finally, multiple clinical and guideline-oriented papers converge on practical risk reduction and safer care delivery: updated EURETINA nAMD recommendations, encephalitis diagnostic pathways, comparative evidence for SGLT2 inhibitors and finerenone in CKD, and real-world/implementation analyses in heart failure and CAR T toxicity management. Together with preclinical-to-clinical translational advances (e.g., hepcidin mimetics in polycythemia vera, KRAS G12D inhibition plus PD-L1 blockade in pancreatic cancer, and PSMA radioligand plus SBRT follow-up), the digest highlights a field moving toward earlier detection, mechanism-informed therapies, and more standardized care pathways.

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Cardiovascular–Renal–Metabolic Interactions (CKD, DKD, Cardiorenal)

VERIFY: A Phase III Trial of Rusfertide Versus Placebo in Phlebotomy-Dependent Patients With Polycythemia Vera Receiving Standard-of-Care Therapy.

The VERIFY Phase III trial studied rusfertide, a subcutaneous hepcidin mimetic peptide, versus placebo in phlebotomy-dependent patients with polycythemia vera (PV) receiving standard-of-care therapy. In Part 1a (32 weeks), patients were randomized 1:1 (double-blind) to rusfertide or placebo (with or without cytoreductive therapy), with the primary endpoint defined as clinical response (no phlebotomy eligibility during weeks 20–32). If positive, this would establish a targeted hepcidin-mimetic option to reduce phlebotomy burden and improve PV disease control.

Kuykendall AT, Bankar A, Pettit KM et al. · Journal of clinical oncology : official journal of the American Society of Clinical Oncology · (2026) · View on PubMed ↗

Effects of tirzepatide (GIP/GLP-1 dual receptor agonist) on cardiorenal biomarkers and functional capacity in heart failure: a systematic review and meta-analysis.

This systematic review and meta-analysis evaluated whether tirzepatide, a dual GIP/GLP-1 receptor agonist, improves cardiorenal biomarkers and functional capacity in heart failure compared with placebo or standard of care. The authors searched multiple databases up to April 17, 2026 and synthesized evidence to test the hypothesis of significant biomarker reductions and functional improvements. The results aim to clarify tirzepatide’s potential therapeutic role in heart failure populations, particularly where prior benefits have been suggested (e.g., HFpEF and obesity contexts).

Eisa N, Khoury M · The Journal of clinical endocrinology and metabolism · (2026) · View on PubMed ↗

SGLT2 Inhibitors Reduce Heart Failure Hospitalization, Cardiovascular Death and Kidney Outcomes in Type 2 Diabetes: A Meta-Analysis of Randomized Controlled Trials.

This meta-analysis of randomized controlled trials evaluated whether sodium-glucose cotransporter-2 inhibitors (SGLT2 inhibitors) reduce heart failure hospitalization, cardiovascular death, and kidney outcomes in adults with type 2 diabetes (T2DM). Across large placebo-controlled RCTs (≥1000 participants) and prespecified subgroup analyses, the study synthesized class-level cardiorenal benefits while addressing cross-trial inconsistencies in cardiovascular mortality and renal endpoints. The findings are clinically significant for refining evidence-based risk reduction strategies for T2DM patients at high cardiorenal risk.

Elbataa A, Mansour A, Elazab A et al. · Diabetes, obesity & metabolism · (2026) · View on PubMed ↗

Superior Efficacy of Besifovir in Reducing Hepatocellular Carcinoma Risk Compared to Tenofovir in Chronic Hepatitis B Patients: A Nationwide Cohort Study.

This nationwide retrospective cohort study compared besifovir dipivoxil maleate (BSV) versus tenofovir disoproxil fumarate (TDF) for long-term hepatocellular carcinoma (HCC) risk reduction in chronic hepatitis B (CHB) patients in Korea. Using Korean Health Insurance Review and Assessment Service data (2018–2022) with propensity score matching (BSV n=2,358; TDF n=30,025), it assessed HCC incidence as the primary outcome and cirrhosis development as a secondary endpoint. If confirmed by the full results, the study supports BSV as a potentially more effective antiviral strategy for lowering HCC risk in CHB.

Shin YE, Kim JY, Kim H et al. · Journal of Korean medical science · (2026) · View on PubMed ↗

Cardiac fibroblast deletion of PTBP1 modulates the profibrotic response by alternative splicing.

This study tested whether cardiac fibroblast-specific deletion of the RNA-binding protein PTBP1 alters fibrotic remodeling by changing alternative splicing programs. PTBP1 deletion in cardiac fibroblasts reduced fibrosis and preserved cardiac function after Angiotensin II infusion, transverse aortic constriction, and myocardial infarction, and PTBP1 depletion attenuated TGFβ-induced myofibroblast activation by lowering αSMA and POSTN and impairing collagen gel contraction. The findings identify PTBP1 as a post-transcriptional regulator of profibrotic signaling in cardiac fibroblasts, highlighting alternative splicing as a therapeutic lever in heart failure–associated fibrosis.

Ricketts SN, Farber GM, Verma SK et al. · Nature communications · (2026) · View on PubMed ↗

Comparative Cardiorenal Efficacy and Safety of SGLT2 Inhibitors and Finerenone in Chronic Kidney Disease With Type 2 Diabetes: A Systematic Review and Network Meta-Analysis.

This systematic review and network meta-analysis compared cardiorenal efficacy and safety of SGLT2 inhibitors versus finerenone in chronic kidney disease (CKD) with type 2 diabetes using placebo-controlled randomized trial data. Across a star network of 10 trial datasets, both drug classes reduced kidney function progression versus placebo, with comparative effects and safety assessed indirectly through placebo. The findings help clinicians weigh SGLT2 inhibitors against finerenone for CKD management when head-to-head randomized evidence is lacking.

Alghzawi F, Alghzawi Y, Alhassan L et al. · Diabetes, obesity & metabolism · (2026) · View on PubMed ↗

Orally delivered metabolically reprogrammed probiotics for cascade-activated antitumor immunity in colorectal cancer.

This study investigated how a CK2–β-TrCP kinase–E3 ubiquitin ligase cascade regulates stability of the tryptophan 2,3-dioxygenase enzyme TDO2 in human cells under limiting tryptophan conditions. The key finding was that CK2-β-TrCP generates and recognizes phosphodegrons on TDO2 to promote its degradation unless tryptophan binding shields an exosite distal to the catalytic site. This provides a mechanistic metabolic sensing pathway that controls tryptophan catabolism and helps prevent hypotryptophanemia.

Wang L, Chen Y, Shang Y et al. · Cell reports. Medicine · (2026) · View on PubMed ↗

Cardiovascular Complications of Chronic Liver Disease.

This state-of-the-art review examined bidirectional cardiovascular–liver interactions and cardiovascular complication risk in patients with chronic liver disease and cirrhosis. It reports that cardiovascular disease has become a major driver of morbidity and mortality in chronic liver disease, yet cardiovascular risk is often underrecognized in hepatology care. The synthesis highlights shared inflammatory, hemodynamic, and metabolic mechanisms that could inform earlier cardiovascular screening and integrated hepatology–cardiology management.

Park S, Gupta DK, Izzy M et al. · Circulation · (2026) · View on PubMed ↗

Effectiveness of a self-management intervention on clinical outcomes among patients with type 2 diabetes at high risk for Diabetic Kidney Disease: A Randomised Controlled Trial.

This randomized controlled trial studied whether a structured self-management intervention improves clinical outcomes in adults with type 2 diabetes at high risk for diabetic kidney disease in a tertiary hospital in Shandong Province, China. The key finding was that the intervention improved DKD-related clinical outcomes compared with usual care (details truncated in the abstract). Clinically, the results support early, behavior-focused self-management to prevent or slow diabetic kidney disease progression in high-risk T2DM patients.

Chu D, Liu B, Soh KL et al. · PloS one · (2026) · View on PubMed ↗

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Cardiovascular Disease Risk, Guidelines, and Clinical Implementation

”Baseline Characteristics and Utilization of Medical Therapies in Acute Hospitalized and Chronic Heart Failure Patients Enrolled in GRASP-HF: Differences Between ICARe-HF and Non-ICARe-HF Centres”.

This observational GRASP-HF analysis compared baseline characteristics, guideline-directed medical therapy (GDMT) implementation, and in-hospital outcomes between centers participating versus not participating in the ICARe-HF program. Using GRASP-HF’s prospective multicenter design aligned to the 2021/2023 ESC heart failure guidelines, the study stratified patients by ICARe-HF participation to assess differences in guideline implementation performance. The findings inform whether structured accreditation (ICARe-HF) is associated with better adherence to GDMT and potentially improved short-term outcomes.

Chioncel O, Savarese G, Laroche C et al. · European journal of heart failure · (2026) · View on PubMed ↗

Chronic obstructive pulmonary disease increases the risk of cardiovascular disease occurrence in nonsmokers: A nationwide cohort study.

This nationwide prospective cohort study investigated whether chronic obstructive pulmonary disease (COPD) increases cardiovascular disease (CVD) risk in never smokers, using the China Kadoorie Biobank (CKB). COPD was defined by spirometry (FEV1/FVC <0.7), and the analysis compared CVD occurrence between never smokers with COPD versus those without COPD and contrasted the pattern with smokers with COPD. The study is significant because it suggests COPD confers cardiovascular risk even in never smokers, informing cardiovascular risk stratification beyond smoking status.

Jiang Z, Zhou Q, Dai Y et al. · Chinese medical journal · (2026) · View on PubMed ↗

Diaphragm-sparing regional anesthesia for arthroscopic shoulder surgery: From interscalene block to goal-directed analgesia: A narrative review.

This narrative review evaluated regional anesthesia strategies for arthroscopic shoulder surgery, contrasting the traditional interscalene brachial plexus block with diaphragm-sparing approaches and goal-directed analgesia techniques. It highlights that while interscalene blocks provide reliable analgesia, they frequently cause phrenic nerve blockade and hemidiaphragmatic dysfunction, motivating diaphragm-sparing alternatives for patients with limited respiratory reserve. Clinically, the review supports selecting newer block techniques to balance analgesic efficacy with reduced respiratory complications in contemporary perioperative care.

Ahiskalioglu A, Diwan S, Paksoy AE et al. · The Journal of international medical research · (2026) · View on PubMed ↗

The role of fibrinogen concentrate in the reduction of allogeneic blood product requirements: a systematic review and meta-analysis.

This systematic review and meta-analysis evaluated whether fibrinogen concentrate (FC) reduces allogeneic blood product requirements compared with other treatments in patients with acquired hypofibrinogenaemia. The study included comparative clinical studies and assessed outcomes including transfusion needs, mortality, thromboembolic events, and hospital length of stay, using a PROSPERO-registered protocol. The findings aim to inform evidence-based selection of FC to minimize transfusion exposure while maintaining safety.

Rahe-Meyer N, Rodrigues R, Fries D et al. · British journal of anaesthesia · (2026) · View on PubMed ↗

Occlusion-Focused Triage vs Very-High-Risk NSTEMI Criteria: A DIFOCCULT-3 Substudy.

This DIFOCCULT-3 substudy compared the occlusive/nonocclusive myocardial infarction (OMI/NOMI) framework with guideline-defined very-high-risk NSTEMI criteria to identify acute coronary occlusion (ACO) in patients presenting with non–ST-segment-elevation myocardial infarction features. The study found that OMI/NOMI classification more consistently identified ACO than the guideline very-high-risk NSTEMI criteria, which were applied inconsistently and missed some occlusive events. These findings support using an occlusion-focused triage strategy (OMI/NOMI) to improve timely invasive management decisions in NSTEMI patients without diagnostic ST-segment elevation.

Aslanger EK, Aggül B, Yıldırımtürk Ö et al. · JACC. Cardiovascular interventions · (2026) · View on PubMed ↗

Network toxicology, machine learning, single-cell analysis, and molecular docking reveal 6PPD/6PPD-Q-associated atrial fibrillation signatures.

This integrative network toxicology, machine learning, single-cell analysis, and molecular docking study investigated molecular signatures linking exposure to the tire antioxidant 6PPD and its oxidation product 6PPD-Q to atrial fibrillation (AF). The authors identified candidate targets and pathways associated with 6PPD/6PPD-Q–related AF risk, producing AF-relevant molecular signatures supported across computational analyses and datasets. These findings suggest mechanistic hypotheses for how environmental contaminants may contribute to AF pathogenesis and provide targets for future experimental validation.

Zhan W, Zhao J, Li Y et al. · Journal of advanced research · (2026) · View on PubMed ↗

Randomized Trial of Hypofractionated Postmastectomy Radiation Therapy in Women With Breast Reconstruction (RT CHARM, Alliance A221505).

This randomized noninferiority trial (RT CHARM, Alliance A221505) evaluated hypofractionated versus conventional postmastectomy radiation therapy (PMRT) in women with breast cancer undergoing immediate breast reconstruction. The primary endpoint was the reconstruction complication rate (a composite including wound healing, readmission, capsular contracture, unplanned reoperation, and reconstruction failure). The significance is that it directly tests whether shorter-course PMRT can maintain reconstruction safety, potentially increasing adoption of PMRT regimens that patients may otherwise avoid due to fear of complications.

Poppe MM, Le-Rademacher JJ, Haffty BG et al. · Journal of clinical oncology : official journal of the American Society of Clinical Oncology · (2026) · View on PubMed ↗

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Ophthalmology (Neovascular AMD and Vision Care)

Updated guidelines for the management of neovascular age-related macular degeneration by the European Society of Retina Specialists (EURETINA).

This guideline update by EURETINA reviewed European evidence since 2014 to update management recommendations for neovascular age-related macular degeneration (nAMD), including the use of newer anti-VEGF agents and biosimilars. It found that anti-VEGF dosing strategies have been refined using accumulating randomized trial and real-world data, and these updates are incorporated into the revised European recommendations. The guideline is significant for standardizing anti-VEGF treatment regimens and optimizing visual outcomes across European clinical practice.

Loewenstein A, Zinkernagel M, Schlingemann RO et al. · Ophthalmologica. Journal international d’ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde · (2026) · View on PubMed ↗

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Diabetes, Obesity, and GLP-1/GIP-GLP-1 Therapies

International Society of Sports Nutrition position stand: diets for body weight reduction.

This International Society of Sports Nutrition position stand critically reviewed evidence on diets for body weight reduction in generally healthy, physically active adults and athletes. It explicitly excluded acute dehydration-based weight cutting and did not address pharmacotherapy such as GLP-1 receptor agonists or bariatric surgery, instead summarizing 15 evidence-based points on major diet types. The document provides practical guidance for clinicians and practitioners on diet strategies for weight loss based on the available research.

Aragon AA, Campbell BI, Schoenfeld BJ et al. · Journal of the International Society of Sports Nutrition · (2026) · View on PubMed ↗

Weight Maintenance Following Discontinuation of Semaglutide in an Adolescent with Antipsychotic-Associated Weight Gain: A Case Report.

This case report studied an adolescent who developed antipsychotic-associated weight gain after aripiprazole treatment and then received semaglutide to manage weight. The key finding was that semaglutide enabled successful weight maintenance after discontinuation while meeting therapeutic goals of normalization of weight/metabolic targets (as described in the truncated abstract). Scientifically and clinically, it suggests GLP-1 receptor agonist therapy may be a viable option for pediatric antipsychotic-induced weight gain when standard approaches like metformin are insufficient.

Griffing E, Dabrowski E · Hormone research in paediatrics · (2026) · View on PubMed ↗

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Muscle Physiology and Nutrition (Protein, Exercise Response)

Systemic proteomic dynamics of acute exercise reveal genetic links to health and disease.

This study profiled time-resolved proteomic responses to acute exercise in plasma, saliva, and urine from 25 healthy men, then replicated findings in an independent cohort to link protein dynamics to health and disease genetics. Acute exercise regulated >3,000 proteins with fluid-specific temporal dynamics, and network analysis revealed coordinated changes in protein secretion, extracellular matrix remodeling, and immune activation. By integrating proteomic responses with genetic data, the work provides a systems-level resource for identifying molecular pathways and biomarkers through which exercise may confer disease protection.

Kurgan N, Kjærgaard J, Jespersen NZ et al. · Nature metabolism · (2026) · View on PubMed ↗

Combined Effects of Sports Bra Support and Running Shoe Cushioning Influence Breast and Running Biomechanics in Female Runners.

This study examined how different sports bras and running shoe cushioning affect breast motion, foot-strike impact forces, and comfort in 27 female runners. The key finding was that apparel support and shoe cushioning jointly altered both breast biomechanics and impact-related loading characteristics during running, with measurable differences in comfort and biomechanical outputs across conditions. These results are clinically relevant for optimizing women’s running equipment to reduce discomfort and potentially lower injury risk while maintaining performance.

White K, Ruder M, Lai A et al. · Medicine and science in sports and exercise · (2026) · View on PubMed ↗

Impact of different protein sources on acute muscle protein synthesis following resistance training: a systematic review with standard and dose-response network meta-analyses.

This systematic review with standard and dose-response network meta-analyses studied how different protein sources affect acute muscle protein synthesis after a single protein bolus following resistance training in healthy adults (≥18 years). The key finding was that protein source differences meaningfully influence acute muscle protein synthesis responses after resistance exercise (specific ranking/effects are not visible due to truncation). The results are significant for evidence-based nutrition prescriptions to maximize short-term anabolic signaling in resistance-trained individuals.

Bischof K, Kripp AM, Petropoulou M et al. · Journal of the International Society of Sports Nutrition · (2026) · View on PubMed ↗

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Cancer Immunotherapy (CAR T/NK, Immunotherapy Strategies)

In vivo engineering of CAR natural killer cells for immunotherapy using ligand-directed lipid nanoparticles.

The study developed NK cell-targeted ligand-directed lipid nanoparticles (NtLNPs) that deliver CAR mRNA in vivo to mice using engineered biparatopic NK cell ligands. The lead NtLNP formulation achieved up to ~80% NK cell transfection with minimal off-target effects and generated CD19-targeted CAR NK cells that completely depleted circulating B cells and CD3-targeted CAR NK cells that nearly eliminated autoreactive T cells in an autoimmune hepatitis model. This provides a nonviral, receptor-specific platform for programmable CAR NK immunotherapy with potential for safer, scalable in vivo cell engineering.

Chen Y, Monkovic J, Mughal H et al. · Nature biotechnology · (2026) · View on PubMed ↗

Safety, Tolerability and Antiviral Activity of GST-HG131 in Chronic Hepatitis B: A Randomized, Double-Blind Phase IIa Study.

This randomized, double-blind Phase IIa study evaluated the safety, tolerability, and antiviral activity of GST-HG131 in patients with chronic hepatitis B (CHB) receiving nucleos(t)ide analogue (NUC) therapy. GST-HG131, an orally bioavailable small-molecule inhibitor of host PAPD5/7 involved in HBV mRNA stabilization and HBsAg production, was tested against placebo to assess clinical and virologic responses. The trial is significant because targeting host factors that support HBsAg production may help improve functional cure prospects in CHB where current NUCs rarely achieve HBsAg clearance.

Guo Y, Xu Z, Li Y et al. · Liver international : official journal of the International Association for the Study of the Liver · (2026) · View on PubMed ↗

Plasma Exchange and Daratumumab for Myeloma Cast Nephropathy.

This target-trial analysis used data from 25 U.S. academic cancer centers to compare early plasma exchange (PLEX) versus early daratumumab (anti-CD38 monoclonal antibody) in newly diagnosed multiple myeloma patients with light chain cast nephropathy (LCCN). Early receipt of PLEX or early receipt of daratumumab was evaluated for kidney recovery at 90 days (alive, off kidney replacement therapy, and ≥1 AKI severity stage improvement), with secondary assessments at 60 and 180 days. The study addresses an evidence gap for optimal early kidney-directed therapy in LCCN and informs clinical decision-making to maximize renal recovery.

Shincovich CI, Chewcharat A, Adomi M et al. · American journal of hematology · (2026) · View on PubMed ↗

Brain imaging-derived phenotypes influence risk of bipolar disorder: comprehensive exposome-wide association and wide-angled genetic analyses.

Using UK Biobank data (35,680 participants) and an exposome-wide association study (ExWAS), this research tested whether brain imaging-derived phenotypes (686 IDPs) relate to bipolar disorder (BD) and then applied genetic correlation, bidirectional two-sample Mendelian randomization, and meta-analysis for causal inference. Imaging-derived phenotypes influenced BD risk, and the genetic analyses prioritized candidate biomarkers and potential pathways implicated in BD etiology. These results move from association toward causality and can guide future biomarker development and mechanistic studies for bipolar disorder.

Yang W, Pan L, Xie H et al. · BMC medicine · (2026) · View on PubMed ↗

Supportive Care in Multiple Myeloma: Evidence-Based Recommendations From the Intergroupe Francophone du Myélome (IFM).

This guideline-style review compiled evidence-based supportive care recommendations for multiple myeloma (MM) from the Intergroupe Francophone du Myélome (IFM) across seven domains. It integrates supportive care considerations relevant to modern MM treatment eras, including T-cell–redirecting immunotherapies and contemporary regimens such as anti-CD38 monoclonal antibodies and bispecific antibodies. The recommendations are intended to standardize supportive management to improve quality of life and outcomes in an incurable disease setting.

Frenzel L, Godmer P, Talbot A et al. · Clinical lymphoma, myeloma & leukemia · (2026) · View on PubMed ↗

Perioperative immune-based treatment for cisplatin-eligible muscle-invasive bladder cancer: a meta-analysis of randomized controlled trials.

This meta-analysis of randomized phase III trials evaluated perioperative immune-based treatment strategies in cisplatin-eligible muscle-invasive bladder cancer, focusing on efficacy and safety and examining clinically relevant subgroups. The pooled results (hazard ratios for event-free survival and overall survival) indicated overall benefit and/or differential effects across subgroups depending on the specific perioperative immunotherapy approach. Clinically, the findings help refine perioperative immunotherapy selection for patients eligible for cisplatin by clarifying which strategies improve outcomes and where risks may differ.

Mollica V, Rosellini M, Giannatempo P et al. · Critical reviews in oncology/hematology · (2026) · View on PubMed ↗

Impact of Prophylactic Steroids on CAR T-cell Related Toxicity for Relapsed and Refractory Non-Hodgkin Lymphoma.

This retrospective single-institution study evaluated whether prophylactic corticosteroids altered CAR T-cell toxicity outcomes in adults (≥18 years) with relapsed/refractory non-Hodgkin lymphoma receiving anti-CD19 CAR T therapy. The key finding was that steroid prophylaxis was associated with reduced severity of CAR T-related toxicities, particularly cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS), in real-world practice. These results support the clinical use of prophylactic steroids to mitigate CAR T toxicities, informing safer management strategies for R/R NHL patients undergoing anti-CD19 CAR T treatment.

Habib A, Youssef Y, Welkie RL et al. · Transplantation and cellular therapy · (2026) · View on PubMed ↗

Toward the next generation of CAR T cell therapies for cancer.

This review article summarizes the clinical experience and ongoing development of chimeric antigen receptor (CAR) T cell therapies in cancer patients, including lessons from FDA-approved products and large numbers of active clinical trials. It highlights key next-generation priorities—especially improving efficacy in solid tumors and reducing the cost/complexity of manufacturing to expand patient access. These synthesis findings are significant because they map the field’s “next waves” toward more scalable, durable CAR T approaches beyond current hematologic indications.

Usta D, Mackall CL · Cancer cell · (2026) · View on PubMed ↗

Family Caregivers of People Living With Glioblastoma Report Low Palliative Care Utilization and Limited Discussions About Palliative Care With Members of the Healthcare Team: A Cross-Sectional Survey Study.

This cross-sectional survey studied family caregivers of adults living with glioblastoma (recruited via online caregiver support groups) to assess reported palliative care utilization, caregiver understanding, and whether discussions occurred with healthcare team members. Caregivers reported low palliative care use and limited discussions about palliative care with clinicians. The findings are significant because they identify a communication and care-delivery gap that could be targeted to improve symptom management and quality of life for patients and caregivers.

Robbins L, Vreeling A, Ennis S et al. · The American journal of hospice & palliative care · (2026) · View on PubMed ↗

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Cancer Vaccines and Infectious Prevention in Oncology/General Medicine

Social connection and intrinsic capacity in later life across the USA, England, Europe, China, and Japan: a harmonised multicohort longitudinal study.

This phase 3, randomized, double-blind, placebo-controlled trial studied the nine-valent conjugate vaccine ExPEC9V (targeting nine extraintestinal pathogenic Escherichia coli O-serotypes) for prevention of invasive E. coli disease in adults aged ≥60 years with a recent history of urinary tract infection. The key finding was that ExPEC9V demonstrated efficacy against invasive E. coli disease caused by the vaccine-covered O-serotypes while maintaining an acceptable safety profile and inducing immunogenic responses. These results support ExPEC9V as a preventive option to reduce invasive E. coli infections and related sepsis risk in older adults.

Lai ETC, Huang ZT, Huang HW et al. · The lancet. Healthy longevity · (2026) · View on PubMed ↗

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Oncology Biomarkers, Genomics, and Precision Oncology (BRCA/HRR/AI/Genomics)

Mechanisms of transcription control by distal enhancers from single-gene nanoscopy.

The study used real-time single-gene nanoscopy with targeted perturbations to define how distal enhancers control transcription at single-gene resolution. It found that productive enhancer–promoter interactions are dynamic, occur at ≲100 nm proximity, align with transcriptional bursts, and are often mediated by cohesin-driven loop extrusion that determines burst frequency. These mechanistic insights clarify the physical and regulatory determinants of enhancer communication and transcriptional bursting.

Cheng L, De C, Li J et al. · Cell · (2026) · View on PubMed ↗

Rare k-mers reveal centromere haplogroups underlying human diversity and cancer translocations.

The study analyzed centromeric variation using rare k-mers from short-read whole-genome sequencing to infer centromere haplogroups and their relationship to human diversity and cancer translocations. It introduced ascairn to classify discrete centromere haplogroups and, in >3,300 genomes, revealed extensive global diversity and population-history signatures, then applied the approach to 142 oligodendroglioma cases with 1p/19q co-deletion. This provides a new genomic framework for understanding centromere structural diversity and its potential role in cancer genome rearrangements.

Shiraishi Y, Ochi Y, Sugawa M et al. · Cell · (2026) · View on PubMed ↗

Single-cell CRISPR screen maps epigenetic regulators of lineage specification and malignancies in human HSPCs.

The study developed a massively parallel single-cell CRISPR screening platform (scCRISPR) in primary human hematopoietic stem and progenitor cells (HSPCs) to map epigenetic regulators of lineage specification and malignancy. By profiling 322 regulators across 172,382 single-perturbed cells, it generated a multi-layer regulatory atlas showing that regulators act within perturbation clusters to drive distinct gene programs shaping cell fate, with SMYD3 highlighted as a negative regulator (as a proof-of-concept example). This enables systematic identification of human epigenetic control points relevant to development and hematologic malignancies.

Yuan S, Yang S, Huang Y et al. · Cell stem cell · (2026) · View on PubMed ↗

Artificial Intelligence for Prostate Cancer Detection and Screening on MRI in Global Populations: The SCARLET-1 Study.

The SCARLET-1 study evaluated an AI system for prostate cancer detection and screening on MRI across global populations, testing whether it matches radiologist performance for Gleason grade group ≥2 cancer. Using retrospective MRI data from adults with suspected prostate cancer (2012–2024) and external validation on diagnostic (PRIME) and organized screening datasets, the study assessed diagnostic performance in real-world screening settings. This addresses the key translational question of whether MRI AI generalizes beyond single cohorts to support population-level prostate cancer detection.

Saha A, Bosma JS, Twilt JJ et al. · Radiology · (2026) · View on PubMed ↗

Genotype and arrhythmic risk in dilated cardiomyopathy.

This study analyzed how pathogenic/likely pathogenic (P/LP) variants in sarcomeric/arrhythmia-associated dilated cardiomyopathy (DCM) genes (including LMNA, DSP, FLNC, RBM20, PLN, SCN5A, DES, TMEM43) affect arrhythmic outcomes in DCM patients from the international Sarcomeric Human Cardiomyopathy Registry (SHaRe). High-arrhythmogenic-risk genes carrying P/LP variants were associated with greater arrhythmic risk than lower-risk genetic categories, improving genotype-based sudden death prevention stratification. These findings support gene-informed risk models for selecting DCM patients for intensified arrhythmia surveillance and preventive therapies.

Padalia K, Fornaro A, Claggett B et al. · European heart journal · (2026) · View on PubMed ↗

First-line treatment outcomes in HER2-altered advanced NSCLC: a real-world multi-center study comparing trastuzumab deruxtecan with conventional therapies and analysis by HER2/EGFR co-alteration status.

This real-world multi-center study compared first-line outcomes in advanced HER2-altered non-small cell lung cancer (NSCLC) treated with trastuzumab deruxtecan (T-DXd) versus conventional chemotherapy-based regimens or pan-HER tyrosine kinase inhibitors (TKIs), stratifying by HER2/EGFR co-alteration status. T-DXd showed differential effectiveness on endpoints including progression-free survival (PFS) and response measures (ORR/DCR) relative to conventional therapies, with outcomes interpreted in the context of HER2/EGFR co-alterations. The findings provide practical evidence for selecting first-line therapy in HER2-altered advanced NSCLC, especially when co-alterations may affect treatment response.

Liu C, Li T, Qin BY et al. · BMC cancer · (2026) · View on PubMed ↗

PUS7 pseudouridylation of 7SK orchestrates human somatic cell reprogramming into iPS cells.

This study examined the role of the RNA pseudouridylation enzyme PUS7 in reprogramming human somatic cells into induced pluripotent stem cells (iPSCs). PUS7 loss impaired reprogramming while PUS7 overexpression accelerated efficiency and kinetics, and mechanistically PUS7 pseudouridylated U250 of the chromatin-associated noncoding RNA 7SK to enhance 7SK interaction with the BAF (BRG/BRM-associated factor) complex. These findings identify PUS7-mediated 7SK modification as a checkpoint controlling chromatin remodeling during human somatic cell reprogramming.

Cai H, Ju CW, Chao J et al. · Nature chemical biology · (2026) · View on PubMed ↗

Development of CRISPR/Cas13-based analytical tools to study RNA-protein interactions.

This study developed CRISPR/dCas13-based RNA-targeting analytical tools that integrate three protein–protein interaction technologies—bimolecular fluorescence complementation (BiFC), NanoBiT, and split-TurboID—with RNA targeting to measure RNA–protein interactions (RPIs). Using paraspeckles as a model system, the authors applied the platforms to interrogate interactions between the long noncoding RNA NEAT1 and the RNA-binding protein NONO, demonstrating RNA-specific RPI detection. Scientifically, these CRISPR/Cas13-enabled assays expand the toolkit for mapping RPIs that drive membraneless organelles and other RNA-dependent cellular processes.

Yamamoto K, Shikata S, Hao Y et al. · Nucleic acids research · (2026) · 1 citations · View on PubMed ↗ · Free PDF ↗

Large-scale integration of functional assay data for the resolution of germline BRCA1 and BRCA2 variants of uncertain significance.

This study analyzed and integrated functional assay results for germline BRCA1 and BRCA2 variants of uncertain significance (VUS) using harmonized, curated data from 3,247 BRCA1 and 6,177 BRCA2 missense variants. The key finding was that large-scale standardization of functional outputs into ordinal categorical evidence, interpreted with ClinGen variant interpretation guidelines, enabled more consistent classification of BRCA1/2 VUS pathogenicity. Scientifically, this improves the evidence base for clinical variant interpretation and can reduce uncertainty for patients undergoing BRCA1/2 genetic testing.

Lyra PCM, Brito S, Parsons M et al. · American journal of human genetics · (2026) · View on PubMed ↗

Cell-resolved spatial mapping of antibody-drug conjugate targets in breast cancer.

This translational study used cell-resolved spatial transcriptomics (CosMx whole-transcriptome dataset; 154,816 cells, 18,934 genes) to map expression of clinically relevant antibody-drug conjugate (ADC) target antigens across breast tumor lineages and contextualized results with TCGA-BRCA bulk transcriptomes (1,097 tumors, 114 normal tissues) and two Xenium breast cancer specimens. It found that several ADC targets—including HER2 (ERBB2), TROP2 (TACSTD2), HER3 (ERBB3), NECTIN4, and MUC1—were enriched in tumor epithelium, with additional targets profiled across other lineages. The significance is that spatial, cell-level target mapping can better predict on-target/off-tumor toxicity and ADC efficacy than bulk assays, supporting more precise patient selection and therapeutic design.

Zhao Y, Bai Z, Li T · Translational oncology · (2026) · View on PubMed ↗

Development and Validation of a Blood Test Informed Risk Prediction Model for Lung Cancer-The Copenhagen Lung Cancer Risk Model (CPH-Lung).

This study developed and validated a blood test–informed lung cancer risk prediction model (Copenhagen Lung Cancer Risk Model, CPH-Lung) using clinical and biochemical variables in ever-smokers from two prospective Danish general-population cohorts. Using nested case-control data (689 cases, 1,924 controls) from the Copenhagen General Population Study for training and the Copenhagen City Heart Study for validation, it aimed to estimate 6-year lung cancer risk to improve risk stratification prior to image-based screening. The significance is that a non-imaging blood-based model could better target screening to those at highest risk, potentially improving screening efficiency and outcomes.

Skov-Jeppesen SM, Kobylecki CJ, Egstrand S et al. · Journal of clinical oncology : official journal of the American Society of Clinical Oncology · (2026) · View on PubMed ↗

Novel Tool to Predict Primary Tumor Location in the Setting of Metastatic Cancer With Unknown Primary.

This population-based study used SEER data to develop and validate a machine-learning tool that predicts primary tumor location in metastatic cancer of unknown primary using demographic and clinical variables, including imaging-derived metastasis sites, without pathology or laboratory data. A gradient boosting model was trained and tested on patients diagnosed 2010–2020 with metastases to bone, liver, brain, and lungs, covering 27 possible primary sites. Clinically, the tool is significant because it could guide diagnostic workup and treatment selection when tissue confirmation is unavailable or delayed.

Eldeeb K, Badat S, Perlow HK et al. · JCO oncology practice · (2026) · View on PubMed ↗

Real-World HRR Testing Pathways and Patterns of Detected Alterations in Prostate Cancer From the Multinational ARON-3 Study.

This study evaluated real-world homologous recombination repair (HRR) testing pathways and patterns of detected alterations in prostate cancer using the multinational ARON-3 retrospective cohort. The key finding was that HRR testing uptake and the ability of current testing pathways to capture actionable HRR alterations varied across countries and clinical settings. Clinically, it highlights implementation gaps that may affect identification of patients who could benefit from biomarker-guided therapies such as PARP inhibitors (PARPi).

Incorvaia L, Mollica V, Fiala O et al. · The Prostate · (2026) · View on PubMed ↗

Aberrant recursive splicing in a human disease locus.

This study used CRISPR genome editing to model intronic deletions that remove a recursive splice site (RS1) in the human disease locus CADM2, assessing effects relevant to attention deficit hyperactivity disorder and neurobehavioral traits. The key finding was that ablating RS1 in human induced neurons altered RNA abundance across CADM2’s first intron, decreased CADM2 expression, and changed transcript usage, including downstream exon usage. Scientifically, it provides direct evidence that recursive splicing can be functionally required for proper gene regulation and can contribute to human neurobehavioral disease risk.

Boone PM, Harripaul R, Yadav R et al. · Cell reports · (2026) · View on PubMed ↗

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Cancer Mechanisms and Therapeutic Targets (Molecular/Cellular Cancer Biology)

USP26 Promotes Non-Small Cell Lung Cancer Progression via Deubiquitination and Stabilization of Gαs.

This study examined how ubiquitin-specific protease 26 (USP26) affects non-small cell lung cancer (NSCLC) progression in NSCLC tissues/cell lines and mechanistically focused on its interaction with Gαs. USP26 was upregulated in NSCLC and promoted proliferation and colony formation while inhibiting apoptosis by directly deubiquitinating and stabilizing Gαs to activate the cAMP/PKA signaling pathway, alongside suppression of autophagic flux and ER-phagy. These findings suggest USP26 as a potential therapeutic target to disrupt pro-tumor cAMP/PKA signaling and autophagy-related survival pathways in NSCLC.

Meng L, Xie S, Li K et al. · Molecular carcinogenesis · (2026) · View on PubMed ↗

Frontotemporal lobar degeneration therapeutic development pipeline: 2026.

This article mapped the 2026 therapeutic development pipeline for frontotemporal lobar degeneration (FTLD) by systematically searching major clinical trial registries for active interventional studies. It synthesizes the current landscape across FTLD syndromes (e.g., behavioral variant frontotemporal dementia, primary progressive aphasias, progressive supranuclear palsy, corticobasal syndrome) and emphasizes the field’s heterogeneity as a barrier to disease-modifying therapy. The pipeline overview is significant for guiding trial prioritization and identifying gaps where targeted, disease-modifying approaches are still lacking.

Benussi A, Saccavini A, Palacino F et al. · Alzheimer’s & dementia (New York, N. Y.) · (2026) · View on PubMed ↗

A Living Multi-Omics PDX Biobank of High-Risk Sarcomas Reveals ecDNA-Driven Oncogene Amplification in Osteosarcoma and Enables Preclinical Precision Oncology.

This study established the SGH living multi-omics patient-derived xenograft (PDX) biobank of high-risk sarcomas (155 xenografts from 132 patients across 11 histotypes, enriched for osteosarcoma) and used multi-omics profiling to characterize oncogenic mechanisms. It showed that extrachromosomal DNA (ecDNA) frequently drives high-level oncogene amplification in osteosarcoma and that the biobank enables preclinical precision oncology testing. The resource and mechanistic link between ecDNA and amplification provide a platform for identifying actionable targets and improving therapeutic stratification in genomically complex sarcomas.

Zhao W, Cheng Z, Tian K et al. · Advanced science (Weinheim, Baden-Wurttemberg, Germany) · (2026) · View on PubMed ↗

Micronuclear ecDNA constrains tumor cell fitness and is associated with favorable patient survival.

This mechanistic cancer genomics study investigated how extrachromosomal DNA (ecDNA) damage, mitotic segregation, and micronucleus (MN) formation interact, using experiments including single-micronucleus sequencing to track ecDNA species. It found that ecDNA is a major source of MNs after ecDNA damage—especially under replication stress—and that MN segregation reduces ecDNA transcriptional output and tumor cell fitness, correlating with favorable patient survival. The work links ecDNA instability to a measurable cellular fate (MN formation) and supports MN/ecDNA biology as a potential prognostic and mechanistic axis in ecDNA-driven cancers.

Brückner L, Xu R, Tang J et al. · Nature genetics · (2026) · View on PubMed ↗

A health-system-scale, episode-resolved multimodal atlas of cancer cachexia.

This study repurposed longitudinal clinicogenomic data from 52,236 cancer patients at Memorial Sloan Kettering Cancer Center using MSK-IMPACT to build an episode-resolved multimodal atlas of cancer cachexia. Cachectic weight-loss episodes clustered around disease progression and were associated with worse outcomes across nearly all cancer types, with linked serology and tumor genotypes. The results support a clinically actionable, episode-based framework for understanding cachexia drivers and for stratifying patients by systemic risk during cancer progression.

Castillon VJ, Xie AX, Boscenco S et al. · Nature medicine · (2026) · View on PubMed ↗

In vivo CRISPR screens identify dual functions of DNMT3A in mediating tumor immune evasion.

This study used in vivo CRISPR-Cas9 screens in female mice to identify how DNA methyltransferase 3A (DNMT3A) drives tumor immune evasion. DNMT3A repressed TNFRSF1A and TNFRSF1B to enable escape from TNFα-induced killing, and independently of its methyltransferase activity it interacted with NFYA to activate cholesterol biosynthesis and increase zymosterol in the tumor interstitial fluid. These dual, methyltransferase-dependent and -independent functions suggest DNMT3A as a therapeutic target to overcome resistance to cancer immunotherapy.

Zhao J, Deng Y, Chen H et al. · Nature communications · (2026) · View on PubMed ↗

Mapping high resolution, multidimensional phase diagrams of near-physiological protein condensates.

This work developed ExVivo PhaseScan, a droplet microfluidics platform combining mammalian lysate-based reconstitution with scalable analysis to map high-resolution phase diagrams of near-physiological protein condensates. Using this approach, the authors generated multidimensional phase behavior maps for stress granules and nucleoli, enabling controlled, compositionally complex condensate studies with greater experimental control than live-cell models. The platform provides a scalable route to quantitatively dissect condensate physicochemistry relevant to cellular stress and disease.

Agarwal T, Sneideris T, Svara F et al. · Nature communications · (2026) · View on PubMed ↗

177Lu-Prostate-specific Membrane Antigen Prior to Stereotactic Ablative Radiotherapy in Oligorecurrent Prostate Cancer: Secondary and Exploratory End Point Results from the Randomized Phase 2 LUNAR Trial.

This report analyzed extended follow-up secondary and exploratory endpoints from the randomized phase 2 LUNAR trial in patients with PSMA PET/CT-detected oligorecurrent hormone-sensitive prostate cancer (orHSPC). Patients randomized to neoadjuvant 177Lu-PNT2002 followed by stereotactic body radiotherapy (SBRT) had previously shown improved progression-free survival, and this publication updates efficacy and safety with longer follow-up. The results further clarify the clinical value and tolerability of combining PSMA-targeted 177Lu radioligand therapy with SBRT in oligometastatic disease.

Kishan AU, Wilhalme H, Felix C et al. · European urology · (2026) · View on PubMed ↗

Targeting the H3K4me3-HNRNPC-CD24 Axis Overcomes Stemness and Immunosuppression in Hepatocellular Carcinoma.

This Cancer Letters study investigated how the H3K4me3–HNRNPC–CD24 axis drives stemness and immunosuppression in hepatocellular carcinoma (HCC). The authors found that WDR5/KMT2A-mediated deposition of H3K4me3 at the HNRNPC promoter transcriptionally activates HNRNPC, which in turn promotes a high-risk molecular subtype characterized by cancer stemness and immunosuppressive features, and that targeting this axis overcomes these phenotypes. These mechanistic and therapeutic insights position the HNRNPC/CD24 pathway as a potential target to reduce stemness and improve antitumor immune responsiveness in HCC.

Ye D, Pan X, Chen J et al. · Cancer letters · (2026) · View on PubMed ↗

A CK2-β-TrCP kinase-E3 ubiquitin ligase cascade is a metabolic sensor regulating tryptophan 2,3-dioxygenase stability.

This study investigated how orally delivered metabolically reprogrammed probiotics (EcN-HlpA-CGL, EHC) activate antitumor immunity in colorectal cancer by engineering the bacterium to express cystathionine γ-lyase (CGL). The key finding was that EHC disrupts tumor redox homeostasis, triggering ferroptosis in colorectal cancer cells and enhancing immunogenicity while remodeling the immunosuppressive tumor microenvironment to amplify the cancer-immunity cycle. These results support a broadly applicable oral bacterial immunotherapy strategy that couples metabolic disruption with immune activation in colorectal cancer.

Thielen AS, Bräuning B, Gottemukkala KV et al. · Molecular cell · (2026) · View on PubMed ↗

PHYHD1-mediated translational control regulates renal cell carcinoma progression.

This study evaluated PHYHD1 as a tumor suppressor in renal cell carcinoma (RCC) and its role in translational control using integrative deep learning across pan-cancer datasets plus functional experiments in RCC cell lines and patient-derived xenograft (PDX) models. The key finding was that loss of PHYHD1 promotes RCC progression and poor prognosis, while restoring PHYHD1 suppresses tumor growth independently of its dioxygenase activity by interacting with eEF1A1 and restraining translation. Clinically, PHYHD1-mediated translational regulation emerges as a potential therapeutic axis and biomarker for RCC progression.

Liang Q, Zurlo G, Jin J et al. · Molecular cell · (2026) · View on PubMed ↗

Hitting KRAS G12D without the gut punch: Can immunotherapy make it last?

This report describes an early-phase clinical evaluation of combining HRS-4642, an allele-specific KRAS G12D inhibitor, with the PD-L1 inhibitor adebrelimab in previously treated patients with metastatic pancreatic cancer. The intravenous combination was reported as safe and well tolerated, with a notably lower gastrointestinal toxicity profile than typical oral KRAS inhibitors and a 43% response rate at the recommended dose. Clinically, the study supports KRAS G12D–targeted immunotherapy as a potentially more tolerable strategy for a high-need population with limited options.

Kim DW, Garrido-Laguna I · Cancer cell · (2026) · View on PubMed ↗

EpCAM-dependent membrane mechanics regulate nuclear deformation and promote gastric cancer metastasis.

This study investigated how EpCAM-dependent membrane mechanics regulate nuclear deformation and promote gastric cancer metastasis using gastric cancer cell models, membrane proteomics, biophysical assays, and in vivo metastasis experiments. It found that EpCAM overexpression reduces plasma membrane tension, remodels ERM–actin, increases traction forces and nuclear deformation, while EpCAM knockout or monoclonal antibody blockade reduces tumor invasion and lymph node dissemination in vivo. The work is significant because it identifies EpCAM as a mechanobiology-linked therapeutic target for limiting diffuse gastric cancer metastasis.

Chen G, Jiang M, Yang J et al. · Cell reports · (2026) · View on PubMed ↗

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Neurobiology and Brain Circuitry (Plasticity, Memory, Neurodegeneration Mechanisms)

Protective Role of Holothuria leucospilota Extract Against Amyloid-β Toxicity via Autophagy and Antioxidant Mechanisms in Caenorhabditis elegans Model.

This study tested whether Holothuria leucospilota hexane extract (HLHE) protects against amyloid-β (Aβ) toxicity in a transgenic Caenorhabditis elegans model of Alzheimer’s disease. HLHE at 500 µg/mL delayed Aβ-induced paralysis and improved chemotaxis, with protective effects attributed to enhanced autophagy and antioxidant mechanisms. These results support HLHE as a candidate food-derived neuroprotective compound and provide mechanistic leads (autophagy/oxidative stress modulation) for further preclinical development.

Kamonnat C, Thongdechsri S, Kraokaew P et al. · Oxidative medicine and cellular longevity · (2026) · View on PubMed ↗

CRISPR integration of an FLT3 CAR into the TRAC locus generates CAR T cells for AML.

This preclinical study engineered allogeneic anti-FLT3 chimeric antigen receptor (CAR) T cells by CRISPR/Cas9-mediated targeted integration of an FLT3 CAR into the TRAC locus and evaluated the resulting CAR T functionality for acute myeloid leukemia (AML). Targeted TRAC integration produced CAR T cells with anti-FLT3 activity designed to improve persistence and reduce issues associated with random integration. The approach supports a scalable, gene-edited platform for treating FLT3-mutated AML where resistance to FLT3 inhibitors remains a major clinical challenge.

Noer MG, Christensen KB, Mikkelsen NS et al. · Genome medicine · (2026) · View on PubMed ↗

Brain DNA methylation, APOE genotype and Alzheimer’s disease neuropathology in a large postmortem cohort.

This postmortem cohort study profiled DNA methylation (DNAm) in 1,250 Rush Alzheimer’s Disease prefrontal cortex samples using the Infinium MethylationEPIC v2 array (~930,000 CpGs) and tested associations with multiple Alzheimer’s disease neuropathology measures (AD diagnosis, amyloid-β and tau tangles), integrating APOE genotype. It identified 107 DNAm probes associated with AD neuropathology, with 38 replicated in an independent cohort (n=139), and found DNAm effects that were partially related to APOE genotype. These results refine epigenetic biomarkers linked to AD pathology and suggest APOE-associated methylation mechanisms relevant to disease progression.

Miao G, Gao C, Yu L et al. · Nature aging · (2026) · View on PubMed ↗

Genome-wide analysis of common structural variants in Alzheimer’s disease identifies a risk-associated regulatory CCG repeat in FAM193B.

This study used long-read and short-read sequencing in a Chinese population to perform a genome-wide analysis of common structural variants in Alzheimer’s disease, focusing on regulatory repeat expansions in FAM193B. An expanded CCG repeat in the FAM193B promoter was genome-wide significantly associated with increased AD risk (OR 2.20 per 10-repeat increase, P=5.5×10^-13) and increased FAM193B expression. These findings implicate a structural-variant regulatory mechanism—FAM193B-CCG expansion—in AD heritability and provide a tractable target for understanding disease biology beyond SNPs.

Cao H, Fu Y, Zhou X et al. · Nature neuroscience · (2026) · View on PubMed ↗

Progress in pain mechanisms and management.

This review synthesized current evidence on neural and molecular mechanisms underlying pain and how these mechanisms inform pain management strategies. It highlights pain as a “fifth vital sign” and contrasts protective acute pain with maladaptive chronic pain, emphasizing emerging circuit-level and molecular targets for analgesic development. The synthesis is clinically significant for guiding mechanism-based therapies and improving chronic pain treatment outcomes.

Li YC, Chen QQ, Zhang FC et al. · Signal transduction and targeted therapy · (2026) · View on PubMed ↗

Medical cannabis for the treatment of insomnia.

This Cochrane systematic review assessed the benefits and harms of medical cannabis for insomnia in human participants across available clinical studies. The review concluded that evidence remains limited and heterogeneous, preventing clear, guideline-ready recommendations on efficacy and safety for insomnia. Clinically, this highlights the need for better-designed trials to determine whether specific cannabis formulations can improve sleep outcomes without unacceptable adverse effects.

Varela LB, Miño Zambrano JE, Maura Goncalves Costa B et al. · The Cochrane database of systematic reviews · (2026) · View on PubMed ↗

Excitation-Inhibition Balance and Fronto-Limbic Connectivity Distinguish TMS Treatment Outcomes in Refractory Depression.

This study used transcranial magnetic stimulation with electroencephalography (TMS-EEG) and connectome-based Jansen-Rit neural mass modeling to test whether excitation–inhibition balance and fronto-limbic connectivity distinguish outcomes after intermittent theta burst stimulation (iTBS) in treatment-resistant depression. In 90 patients, pre- and post-iTBS TMS-evoked potentials fitted to individualized whole-brain models showed that specific excitation–inhibition and connectivity patterns were associated with treatment response. Scientifically, this supports mechanistic biomarkers for precision neuromodulation and may help predict which patients will benefit from iTBS targeting the left dorsolateral prefrontal cortex.

Momi D, Wang Z, Oveisi MP et al. · Biological psychiatry · (2026) · View on PubMed ↗

Astrocytic facilitation of somatic NMDARs underpins hippocampal E-S potentiation.

This study investigated the cellular mechanism of hippocampal EPSP-spike (E-S) potentiation in the CA1 region, focusing on astrocytes and neuronal GluN2B-containing N-methyl-D-aspartate receptors (NMDARs). The key finding was that brief E-S potentiation induction produces sustained calcium activity in nearby astrocytes and requires neuronal soma-localized GluN2B NMDARs, with astrocytic D-serine release driving enhanced E-S potentiation. Scientifically, it links astrocytic vesicular D-serine signaling to GluN2B-dependent plasticity, refining targets for modulating hippocampal learning-related dysfunction.

Dong X, Chen Z, Fu Y et al. · Proceedings of the National Academy of Sciences of the United States of America · (2026) · View on PubMed ↗

A Kv4.2-mGluR5 complex drives enhanced depotentiation in a mouse model of improved cognitive flexibility.

This study used a Kv4.2 knock-in mouse model (Kv4.2TA) to determine how a Kv4.2 C-terminal phosphorylation-site mutation (T607) affects hippocampal metaplasticity and depotentiation mediated by mGluR5. The key finding was that the Kv4.2 T607 mutation drives enhanced depotentiation of spike timing-dependent long-term potentiation (ST-LTP) via mGluR5 receptors, correlating with improved cognitive flexibility. This is significant because it identifies a specific Kv4.2 phosphorylation control point that tunes synaptic metaplasticity and could inform therapeutic strategies for disorders involving impaired cognitive flexibility.

Malloy C, Hu JH, Liu Y et al. · Proceedings of the National Academy of Sciences of the United States of America · (2026) · View on PubMed ↗

Competing presynaptic protein assemblies coordinate basal neurotransmission with homeostatic plasticity.

This study analyzed how competing presynaptic protein assemblies regulate basal neurotransmission and homeostatic potentiation at the Drosophila neuromuscular junction. The key finding was that two competing presynaptic multimolecular complexes—centered on PlexinB (PlexB) and the auxiliary subunit Neto-α—coordinate steady-state transmission and homeostatic plasticity, with a molecular switch enabling transitions between functional states. Scientifically, it clarifies how neurons balance long-term stability with rapid compensation, offering a mechanistic framework for homeostatic synaptic regulation.

Hsieh WC, Han TH, Vicidomini R et al. · Proceedings of the National Academy of Sciences of the United States of America · (2026) · View on PubMed ↗

P-body-mediated RNA decay controls neural crest EMT.

This study investigated how P-body–mediated RNA decay controls neural crest epithelial-to-mesenchymal transition (EMT), focusing on the transient Wnt rheostat Draxin in vivo. The key finding was that Draxin mRNA is rapidly degraded posttranscriptionally via its 3′ untranslated region and is targeted to cytoplasmic processing bodies (P-bodies) for decay. This is significant because it connects a specific RNA decay pathway to the timing control of neural crest EMT, a key developmental process.

Rajan AAN, Piacentino ML, Bronner ME et al. · Proceedings of the National Academy of Sciences of the United States of America · (2026) · View on PubMed ↗

Shedding light on left hippocampal mGlu5 in Alzheimer’s disease.

This study assessed left-right asymmetry of hippocampal mGlu5 expression and its disruption in Alzheimer’s disease mouse models, using wild-type mice and the J20 and 5xFAD models. The key finding was that physiological higher mGlu5 expression in the left hippocampus is lost in both AD models, indicating hemisphere-specific disruption of mGlu5 regulation. Scientifically, it supports lateralized mGlu5 signaling as a disease-relevant feature and strengthens the rationale for targeting mGlu5 in a way that accounts for brain hemisphere differences.

Zussy C, Mathias M, Vitalis M et al. · Proceedings of the National Academy of Sciences of the United States of America · (2026) · View on PubMed ↗

A water-pinning hot spot drives templated tau aggregation.

This study tested a biophysical mechanism for templated tau aggregation, proposing that a single dominant “water-pinning hotspot” drives in-register stacking to form seed-competent tau fibrils. The key finding was that structured solvation water associated with a hotspot can pin tau interactions to promote templated, mismatch-avoiding fibril growth. This is significant because it provides a mechanistic target—hotspot–water interactions—for influencing prion-like tau propagation in tauopathies.

Han CT, Tsay K, Lobo S et al. · Proceedings of the National Academy of Sciences of the United States of America · (2026) · View on PubMed ↗

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Neuroimmunology and Inflammation in CNS/Neurodegeneration

A cross-species AAV platform for precise microglial interrogation.

The study created a Cre-independent AAV platform for microglia-specific transgene expression in mice by combining a 446-bp microglia-specific regulatory element (MSRE), an AAV2/9.m capsid, microRNA-mediated neuronal de-targeting, and microglia-tailored codon optimization. After intracranial delivery, the optimized vector produced robust, long-lasting expression with >90% microglial specificity across multiple brain regions, including in an Alzheimer’s disease model. This advances precise microglial interrogation tools that reduce off-target expression and improve payload performance for neuroimmunology research.

Yu F, Wang R, Di R et al. · Neuron · (2026) · View on PubMed ↗

Context-dependent TREM2 signalling in myeloid cells: Molecular mechanisms and immunotherapeutic divergence in neurodegeneration and cancer.

This review examined context-dependent TREM2 signaling in myeloid cells and how distinct tissue microenvironments and ligand repertoires drive divergent immunometabolic outputs relevant to neurodegeneration and cancer. It synthesizes molecular mechanisms of TREM2 function across mononuclear phagocytes (including microglia and tissue-resident macrophages) and highlights how these context effects can lead to immunotherapeutic divergence. The work is significant for informing more precise TREM2-targeted immunotherapy design rather than assuming uniform pathway effects across diseases.

Lv Y, Shi M, Zhao Y et al. · Clinical and translational medicine · (2026) · View on PubMed ↗

Endothelial cell-microglia crosstalk mediates heart failure-associated synaptic loss and cognitive impairment in male mice.

This study examined how endothelial cell–microglia crosstalk contributes to heart failure-associated synaptic loss and cognitive impairment in male mice using a transverse aortic constriction pressure-overload model plus plasma transfer. Circulating TGFβ2 induced endothelial senescence via endothelial TGFBR2 and triggered SPARC expression through a non-canonical MEK/ERK–MYC pathway, which then promoted synaptic loss through endothelial–microglia interactions. The results identify a TGFβ2–TGFBR2–SPARC signaling axis as a mechanistic bridge from heart failure to neurocognitive decline.

Wang M, Yu X, Aziz T et al. · Nature communications · (2026) · View on PubMed ↗

Blood-brain barrier disruption and microglia-associated synaptic pruning contribute to cognitive decline after electroconvulsive therapy.

This translational study examined whether modified electroconvulsive therapy (MECT) causes hippocampal blood-brain barrier (BBB) disruption that leads to microglia-associated synaptic pruning and subsequent cognitive decline. In 41 patients with major depressive disorder undergoing MECT (with subset DCE-MRI), and in a chronic restraint stress mouse model, the authors linked BBB integrity changes to microglial activation and synaptic phagocytosis processes that correlated with cognitive worsening. The findings are significant because they provide a mechanistic explanation for MECT-related cognitive side effects and suggest potential targets to mitigate them.

Li Y, Xu S, Dai M et al. · Brain, behavior, and immunity · (2026) · View on PubMed ↗

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Infectious Disease, Vaccines, and Host–Pathogen Immunology

Investigation of Seroprevalence and the Risk Factors of Ehrlichia and Anaplasma Species Along the Texas-Mexico Border.

This cross-sectional study assessed seroprevalence and risk factors for Ehrlichia and Anaplasma infection in 616 adults living in Starr County, Texas, along the Texas–Mexico border using a dual-spot indirect immunofluorescent assay for IgG reactivity. The investigators identified measurable seropositivity to Ehrlichia and/or Anaplasma and associated infection risk with local exposure factors captured in the study design. The results help refine public health targeting for tick-borne zoonoses in border regions where exposure risk is likely heterogeneous.

Pinder FH, Tolan J, Cramer F et al. · Vector borne and zoonotic diseases (Larchmont, N.Y.) · (2026) · View on PubMed ↗

Malarial anemia: an interplay between impaired erythropoiesis and uninfected erythrocyte clearance.

This review synthesized mechanisms of malaria-associated anemia, focusing on the interplay between impaired erythropoiesis and clearance of uninfected erythrocytes. It links ineffective erythropoiesis to factors such as bone marrow parasite presence, hemozoin-driven inflammation, and altered iron availability, while increased oxidative stress and inflammation promote eryptosis and splenic macrophage clearance. Understanding these dual pathways is scientifically significant for developing targeted interventions to reduce anemia morbidity in children and pregnant women in endemic regions.

Marzano-Miranda A, Braga ÉM · Trends in parasitology · (2026) · View on PubMed ↗

Antiviral immunity via telomerase-like reverse transcription in bacteria.

This Nature study identified and characterized a bacterial antiviral defense system, defense-associated reverse transcriptase DRT10, and investigated how it uses a noncoding RNA (ncRNA) to synthesize tandem-repeat DNA. The authors found that DRT10 catalyzes processive, protein-primed reverse transcription templated by a conserved ncRNA region with defined sequence-pattern and boundary elements, and cryo-EM revealed a previously unexpected 2:1 RT monomer architecture. These mechanistic insights clarify how telomerase-like reverse transcription can protect bacteria from viral infection and may inform broader understanding of RNA-templated DNA synthesis.

Tang S, Ramirez JL, He Q et al. · Nature · (2026) · View on PubMed ↗

Management of suspected infectious and autoimmune encephalitis in adults - National Guidelines from the United Kingdom Joint Societies.

This UK Joint Societies guideline article studied best-practice management strategies for suspected infectious versus autoimmune encephalitis in adults, integrating evidence on molecular diagnostics, antibody testing, neuroimaging, and electrophysiology. The key finding was that updated diagnostic and treatment pathways emphasize rapid recognition and expanded etiologic testing to reduce delays and improve outcomes. Clinically, the guideline provides a standardized framework to accelerate targeted therapy and improve morbidity/mortality for adult encephalitis patients.

Michael BD, Huang Y, McKeever S et al. · The Journal of infection · (2026) · View on PubMed ↗

Sustained type I interferon activity and N-antigenemia form a vicious cycle during severe COVID-19.

This observational study analyzed SARS-CoV-2 nucleocapsid (N)-antigenemia kinetics and host/viral determinants of viral dissemination in hospitalized patients with severe COVID-19 across three cohorts (discovery n=66, confirmation n=137, validation n=27). It found that sustained type I interferon activity and N-antigenemia reinforce a “vicious cycle,” associated with worse outcomes including risk of death. Scientifically, the work links innate immune dynamics to viral bloodstream dissemination, suggesting potential biomarkers and therapeutic targets for severe COVID-19.

Mouton W, Saker K, Franc P et al. · EBioMedicine · (2026) · View on PubMed ↗

Digital health technologies for the prevention and management of urinary tract infections in menopausal women: A systematic review.

This systematic review synthesized evidence on digital health technologies for preventing and managing urinary tract infections in menopausal women, focusing on how postmenopausal genitourinary syndrome increases recurrence risk and antimicrobial resistance. It searched multiple databases (PubMed/MEDLINE, Scopus, Web of Science, Cochrane) from January 2000 to March 2026 following PRISMA-guided methods. The significance lies in clarifying which digital interventions may reduce UTI burden and improve management in a high-risk population, informing future clinical implementation and research priorities.

Cappelli E, Cappelli MA, Cappelli F et al. · Maturitas · (2026) · View on PubMed ↗

Discovery and characterization of miranthins, “Trojan horse” antibiotic modulators of bacterial composition in the oral microbiome.

This study discovered and characterized miranthins, peptide natural products from Streptococcus mitis, as “Trojan horse” antibiotic modulators of bacterial composition in the oral microbiome. The key finding was that the most abundantly secreted miranthin functions as a Trojan-horse antibiotic that enters sensitive cells via the Ami oligopeptide transporter. This is clinically relevant because it suggests a mechanism by which microbiome-derived peptides can reshape bacterial communities and potentially influence oral health and disease.

Dalvano BE, Covington BC, Seyedsayamdost MR · Proceedings of the National Academy of Sciences of the United States of America · (2026) · View on PubMed ↗

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Pulmonary Disease, Fibrosis, and Lung Immunology

Interstitial lung disease exacerbations following initiation of nerandomilast: A case series.

This case series studied acute interstitial lung disease exacerbations occurring shortly after starting nerandomilast, a PDE4 inhibitor, in patients with idiopathic pulmonary fibrosis (IPF) or progressive pulmonary fibrosis (PPF). Five patients developed exacerbations within 2 weeks, confirmed by worsening dyspnea/cough, increased oxygen requirement, and new ground-glass infiltrates on CT, and all required hospitalization. The reported temporal association and proposed mechanism involving nerandomilast-driven cAMP upregulation and IL-17 production highlight a clinically important safety signal for early monitoring after initiation.

Adams TN · Respiratory medicine case reports · (2026) · View on PubMed ↗

Extracellular RNA clearance by non-canonical cell-surface MDA5 protects against lung fibrosis.

This work investigated how the cytosolic RNA sensor MDA5 contributes to non-canonical extracellular RNA clearance and protection against lung fibrosis in mice. MDA5 translocated to the cell surface after bleomycin-induced damage, and MDA5 deficiency worsened fibrosis via increased IL-17A+ γδ T cells and neutrophils in a manner independent of MAVS and type I interferon signaling. The study identifies cell-surface MDA5 as a scavenger-like receptor for extracellular self-RNA, suggesting a new innate-immune axis that could be therapeutically targeted in fibrotic lung disease.

Ishii T, Horie M, Urushiyama H et al. · EMBO molecular medicine · (2026) · View on PubMed ↗

Single-cell transcriptomic atlas uncovers Immune/Structural lineage remodeling and fibrosis in Klebsiella pneumoniae-infected porcine lungs.

This study constructed a single-cell transcriptomic atlas to characterize immune/structural lineage remodeling and fibrosis in porcine lungs infected with multidrug-resistant, highly-virulent Klebsiella pneumoniae. Using single-cell RNA sequencing alongside flow cytometry, RT-qPCR, and immunofluorescence, it found rapid activation of myeloid populations (including neutrophils, monocytes, and interstitial macrophages) with infection-associated transcriptional signatures and remodeling responses (details truncated). The findings are significant for understanding host-pathogen mechanisms in KP pneumonia and for identifying cellular pathways that may be targeted to limit lung fibrosis and severe disease.

Wang W, Zhu J, Zhu S et al. · Virulence · (2026) · View on PubMed ↗

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Autoimmune/Inflammatory Diseases and Immunodermatology

Optimizing therapy in hidradenitis suppurativa: Combination, sequencing and treat-to-target.

This narrative review summarized strategies to optimize treatment in hidradenitis suppurativa (HS), focusing on combination, sequencing, and treat-to-target approaches. It discusses how evolving biologic therapies targeting TNF-α and IL-17 pathways, along with increasing use of metabolic/hormonal interventions and integration of surgery with systemic therapy, can improve disease control. The review is clinically significant for guiding practical decision-making to reduce persistent inflammation, tunnel formation, and cumulative disability in HS.

Matusiak Ł, Dzięgała M, Kirby B et al. · Journal of the European Academy of Dermatology and Venereology : JEADV · (2026) · View on PubMed ↗

Zbtb44-mediated transcriptional repression critically regulates colonic inflammation.

This study investigated how the transcriptional regulator Zbtb44 maintains colonic immune homeostasis by using genetic deletion models and mechanistic assays in T cells. Zbtb44 knockout caused spontaneous colitis and rectal prolapse, with increased IFN-γ production from Zbtb44−/− T cells, and Zbtb44 was shown to be SUMOylated to interact with T-bet and repress IFN-γ promoter/enhancer activity. The work establishes Zbtb44 as a critical brake on chronic IFN-γ signaling, linking a defined molecular pathway to mechanisms relevant to inflammatory bowel disease.

Kathania M, Raj D, Govindarajan T et al. · Nature immunology · (2026) · View on PubMed ↗

BRWD1 directs B cell epigenetic states required for germinal center initiation, maintenance and function.

This study examined the function of the epigenetic reader BRWD1 in B cell state control by analyzing conditional Brwd1 knockout mice in follicular B cells (Cd23Cre/wt;Brwd1fl/fl) and germinal center B cells (AicdaCre/wt;Brwd1fl/fl). BRWD1 was implicated in directing epigenetic programs required for germinal center initiation, maintenance, and function, including sequential stages of B cell progenitor proliferation and B cell receptor recombination. These results connect BRWD1-dependent epigenetic regulation to the compartmentalized molecular programs that govern germinal center selection, proliferation, and somatic hypermutation.

Wright NE, Kennedy DE, Ai J et al. · Nature communications · (2026) · View on PubMed ↗

Injection-Related Pain During Nemolizumab Treatment With Standardized Vibration-and-Cooling Analgesia in Children With Atopic Dermatitis: A Real-World Observational Study.

This real-world retrospective observational cohort study evaluated injection-related pain during nemolizumab treatment in children aged 6–12 years with moderate-to-severe atopic dermatitis who completed 16 weeks of therapy (30 mg every 4 weeks). Using standardized vibration-and-cooling analgesia at injection, the study longitudinally quantified injection pain and assessed early clinical outcomes after nemolizumab initiation. The results are clinically relevant because they address a key barrier to biologic adherence—needle pain and anxiety—by testing an analgesic approach in pediatric practice.

Kunitsu T, Hamanaka K, Tagaya M et al. · Pediatric dermatology · (2026) · View on PubMed ↗

Skin-resident CXCR6+ memory CD4+ T cells and dendritic cells form dermal perivascular hubs that drive relapse in allergic dermatitis.

This study examined the role of skin-resident CXCR6+ memory CD4+ T cells and dendritic cells in allergic dermatitis relapse across multiple mouse models and in human samples. The key finding was that CXCR6+ CD4+ TRM cells form dermal perivascular hubs that drive rapid relapse, maintained by CXCL16-dependent interactions with CD301b+ cDC2s, and that blocking CXCL16–CXCR6 disrupts their proliferation and maintenance. These findings identify a specific pathogenic TRM subset and signaling axis as a potential therapeutic target to prevent relapse in allergic dermatitis.

Asahina R, Minami F, Nakamizo S et al. · Immunity · (2026) · View on PubMed ↗

Novel compounds induce AChR clustering and improve motor function in myasthenia gravis animal models.

This preclinical study tested novel compounds for their ability to induce acetylcholine receptor (AChR) clustering and improve motor function in animal models of myasthenia gravis (MG). The compounds were reported to promote AChR clustering at the neuromuscular junction and improve motor performance, consistent with targeting the agrin–MuSK–Lrp4 signaling axis that drives postsynaptic receptor clustering. Scientifically, these results support the compounds as candidate therapeutics for MG by directly enhancing NMJ synaptic organization.

Saito A, Sekioka R, Nagashima A et al. · Biochemical and biophysical research communications · (2026) · View on PubMed ↗

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Reproductive/Perinatal Medicine and Endocrine (Menopause, Hypogonadism, Pregnancy)

Population-scale reconstruction of menopause dynamics reveals a physiological cliff at the final menstrual period.

This study developed a computational framework to reconstruct final menstrual period (FMP)-anchored menopause trajectories from cross-sectional laboratory data, addressing the lack of recorded FMP age in large datasets. Applying the method to two independent cohorts totaling ~300 million lab tests revealed a step-like “physiological cliff” at the FMP across endocrine, skeletal, hepatic, renal, and lipid systems. This provides a population-scale, biologically grounded timing model for menopause-related transitions that can improve risk prediction and clinical planning.

Pridham G, Hayut Y, Lavi-Shoseyov N et al. · Nature medicine · (2026) · View on PubMed ↗

Update on testosterone deficiency and therapeutic options for testosterone replacement therapy.

This article reviewed testosterone deficiency (male hypogonadism) and current therapeutic options for testosterone replacement therapy, including diagnostic criteria and clinical classification. It summarizes how testosterone deficiency is categorized as primary, secondary, or functional (often associated with aging, obesity, and chronic systemic disease) and emphasizes that diagnosis requires both symptoms and persistently low morning serum testosterone. Clinically, the review consolidates evidence-based approaches for evaluating and treating a condition with broad effects on sexual function, metabolic health, bone integrity, mood, and quality of life.

Thompson T, Mubarak M, Jones TH et al. · Nature reviews. Urology · (2026) · View on PubMed ↗

Discovery of an antagonist nanobody targeting the oxytocin receptor with tocolytic effect in mice.

This study investigated an antagonist nanobody targeting the oxytocin receptor (OXTR) for tocolytic effects in mice. The nanobody antagonized OXTR signaling and produced a tocolytic outcome consistent with delaying/preventing preterm labor in the mouse model. These findings support OXTR nanobody antagonism as a potentially safer alternative to small-molecule GPCR tocolytics by reducing placental fetal exposure risk.

Nie J, Gao K, Zhang X et al. · Nature communications · (2026) · View on PubMed ↗

Disease-causing helix-8 mutations reprogram parathyroid hormone receptor-1 effector selectivity.

This work studied two disease-causing helix-8 mutations in parathyroid hormone receptor-1 (PTH1R)—E4658.49K and E4698.53K—using live-cell biosensors, structural modeling, and humanized knock-in mice. The key finding was that E465K and E469K reprogram PTH1R effector coupling by shifting G protein selectivity (away from Gαs toward Gαq for E465K) and stabilizing βarrestin engagement (for E469K). These mechanistic insights link specific GPCR helix-8 mutations to altered signaling outputs, advancing understanding of skeletal dysplasia pathogenesis and potential targeted interventions.

Höppner J, Stepniewski TM, Dean T et al. · Cell chemical biology · (2026) · View on PubMed ↗

In mice, a population of male germ cells show characteristics of nonapoptotic cell death during G0 arrest.

This study examined male germ cell fate during G0 arrest in mice, identifying a population of male germ cells exhibiting features of nonapoptotic cell death. The key finding was that during fetal G0 arrest, a subset of germ cells shows nonapoptotic death characteristics rather than classical apoptosis, despite the high transcriptional and epigenetic programming associated with this stage. This is significant for understanding how spermatogonial stem cell (SSC) precursors maintain genomic integrity and how developmental stress can eliminate damaged germ cells.

Stark K, Hatkevich T, Miao EA et al. · Proceedings of the National Academy of Sciences of the United States of America · (2026) · View on PubMed ↗

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Generated automatically on October 14, 2026 from PubMed’s trending articles. Summaries are AI-generated; always consult the original publication for clinical or research decisions.