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Automated digest · 98 articles · 15 research areas · April 23, 2026

Overview​

Across this week’s set, a dominant thread is the coupling of metabolism to cell fate—spanning mitochondrial lipid/redox control, lactate-driven epigenetic regulation, and ferroptosis sensitivity. Work on aging in C. elegans links declining phosphatidylcholine (PC) synthesis to mitochondrial aging as a malleable trigger, while related studies emphasize redox timing (circadian redox oscillations) and ER glutathione export (SLC33A1) as mechanistic control points. In parallel, multiple cancer papers converge on metabolic “switches” that determine whether tumors undergo regulated death: PRMT5 inhibition sensitizes B-cell lymphomas to ferroptosis via an AKT–MYC–ATF5–SLC7A11 axis; FAAH promotes ferroptosis resistance in lung adenocarcinoma through STAT3 palmitoylation; and broader reviews synthesize how programmed cell death programs shape immune microenvironments and therapy response.

A second major theme is immunotherapy optimization through microenvironment engineering and immune targeting. Several studies focus on how to overcome immunosuppression in solid tumors: intracellular IL-23R supports AML mitotic viability via non-canonical spindle interactions; NKG2A-defined dysfunctional NK cells in ovarian cancer can be targeted to improve NK–CD8+ coordination; and cycling Tregs emerge as orchestrators of immune escape during DCIS-to-invasive progression. Complementing these, microbiome-directed approaches (including F. prausnitzii enzyme-specific effects on PD-L1 trafficking and evidence that fecal bile acid normalization after FMT may mediate recurrent C. difficile improvements) reinforce the idea that immune outcomes can be tuned by metabolic ecology. Clinical translation is reflected in multiple guideline/consensus and comparative-effectiveness efforts (e.g., MELAS/SLE consensus, cardiogenic shock recommendations, and comparative stent/ICI reaction risk syntheses), underscoring a push toward standardized decision-making.

Finally, the digest highlights a growing emphasis on biomarkers and mechanistic mapping—especially for neurodegeneration and aging risk. Sleep variability and plasma klotho are explored as early indicators of Alzheimer’s pathology and cognitive decline, while imaging/analysis advances (brain-age gap via MRI with causal inference; BRIDGE for voxel-to-cell ground truth mapping) aim to connect signals to underlying biology. Developmental and systems-level resources (human peri-gastrulation embryo models, fetal olfactory atlases, and whole-organism spatial transcriptomics) further show how new experimental platforms are accelerating mechanistic discovery. Together, these studies suggest the field is increasingly moving from descriptive associations toward controllable biological levers—metabolic, immune, and temporal—to improve outcomes across aging, infection, and cancer.

Mitochondrial biology & aging​

Aging-associated decline of phosphatidylcholine synthesis is a malleable trigger of natural mitochondrial aging.​

The study investigated how aging-associated changes in phosphatidylcholine (PC) synthesis affect mitochondrial aging in wild-type Caenorhabditis elegans and in long-lived clk-1(qm30) and isp-1(qm150) mitochondrial mutants, using proteomics, lipidomics, genetics, functional assays, and follow-up transcriptomics/metabolomics in humans. It found that a decline in PC synthesis is a malleable trigger of natural mitochondrial aging, linking lipid metabolic remodeling to mitochondrial functional deterioration despite persistent mitochondrial inefficiency. These findings suggest that targeting PC biosynthesis/lipid metabolic pathways could be a strategy to modulate mitochondrial aging and improve metabolic resilience during late life.

Poliezhaieva T, Li Y, Chaudhari PS et al. · Nature communications · (2026) · View on PubMed ↗

SLC33A1 exports oxidized glutathione to maintain endoplasmic reticulum redox homeostasis.​

This study investigated how the endoplasmic reticulum (ER) maintains redox balance, focusing on glutathione transport in mammalian cells. Using rapid ER immunopurification for proteome/metabolome profiling combined with CRISPR screening, it identified SLC33A1 as the major ER exporter of oxidized glutathione (GSSG), where loss of SLC33A1 disrupts ER redox homeostasis. The significance is that SLC33A1-mediated GSSG export is a key mechanistic control point for ER function and secretory/membrane protein maturation.

Liu S, Gad M, Li C et al. · Nature cell biology · (2026) · View on PubMed ↗

Redox rhythms promote fitness by modulating ageing-dependent reprogramming.​

This study examined how age-related disruption of redox oscillations affects organismal fitness and aging-dependent transcriptional reprogramming in male aged mice. It found that disrupted redox rhythms are common diurnal alterations during aging and that time-restricted antioxidant/pro-oxidant interventions restore redox rhythms, improving glucose metabolism, motor performance, and aging-related phenotypes in liver and skeletal muscle. The significance is that targeting circadian redox timing may be a strategy to mitigate aspects of metabolic and functional decline with age.

Wang X, Cui SS, Li XK et al. · Nature metabolism · (2026) · View on PubMed ↗

Single-mRNA imaging and modeling reveal coupled translation initiation and elongation rates.​

This eLife study used SunTag live-cell single-mRNA imaging together with a TASEP-based hidden Markov model to quantify translation initiation and elongation rates across mRNAs with diverse coding sequences. It found strong coupling between initiation and elongation such that ribosome density remained consistently low (≤12% occupancy), and this homeostatic coupling persisted during pharmacological inhibition of the elongation factor eIF5A. These mechanistic insights improve quantitative models of protein synthesis and may guide strategies to modulate translation in disease.

Lamberti I, Chao JA, Gobet C et al. · eLife · (2026) · View on PubMed ↗

Uncovering shared and tissue-specific molecular adaptations to intermittent fasting in liver, brain, and muscle.​

This study used comprehensive proteomics and transcriptomics to characterize shared and tissue-specific molecular adaptations to intermittent fasting in male C57BL/6 mice across liver, skeletal muscle, and cerebral cortex. After 16-hour daily fasting for 4 months (IF16), intermittent fasting improved metabolic markers (lower blood glucose, HbA1c, and cholesterol; higher ketone bodies) and produced organ-specific proteomic/transcriptomic responses. These findings clarify how intermittent fasting remodels metabolism differently by tissue, informing translational biomarker and mechanism studies for metabolic flexibility.

Fan Y, De Silva S, Tabassum NI et al. · eLife · (2026) · View on PubMed ↗

Cardiometabolic health (diet, drugs, biomarkers)​

Evidence-Based Recommendations on the Use of Inclisiran in Patients With Chronic Kidney Disease.​

This evidence-based recommendations manuscript studied the clinical use of inclisiran in patients with chronic kidney disease (CKD), synthesizing available clinical trial evidence and expert specialist opinion to create a practical suitability stratification tool. It concluded that inclisiran—an siRNA targeting hepatic PCSK9 synthesis—can be used to address CKD-associated dyslipidemia and ASCVD risk, particularly where statin intolerance or polypharmacy limits options. Scientifically and clinically, the recommendations support a structured approach to deploying long-acting PCSK9-targeting therapy to improve LDL-C management in CKD.

Sharma S, Kalra S, Sahay M et al. · Nephrology (Carlton, Vic.) · (2026) · View on PubMed ↗

The Effect of Empagliflozin on Renal Outcomes in Patients With Established Cardiovascular Disease: Systematic Review and Meta-Analysis of Randomised Placebo-Controlled Trials.​

This systematic review and meta-analysis studied the effect of empagliflozin (an SGLT2 inhibitor) on renal outcomes in patients with established cardiovascular disease by pooling randomized placebo-controlled trials. It found that empagliflozin improves renal outcomes compared with placebo, with attention to effect size and potential heterogeneity across cardiovascular populations. The results are clinically important because they strengthen evidence for using empagliflozin to protect kidney function in high-risk patients with coexisting CVD.

Bahardoust M, Rad FN, Mousavi S et al. · Endocrinology, diabetes & metabolism · (2026) · View on PubMed ↗

Associations of plant-based diets with all-cause and cause-specific mortality and life expectancy among participants with cardiometabolic disorders from UK, US, and China.​

This study examined associations between plant-based diet patterns and all-cause and cause-specific mortality and life expectancy among 78,151 participants with cardiometabolic disorders (obesity, diabetes, or CVD) across UK Biobank, NHANES, and CLHLS. It found that plant-based diet indices were associated with differences in mortality risk and estimated life expectancy in these high-risk populations. The findings are significant because they inform dietary counseling and public health strategies aimed at improving longevity in people with cardiometabolic disease.

Tan B, Li Z, Chen P et al. · European journal of preventive cardiology · (2026) · View on PubMed ↗

Fructose: metabolic signal and modern hazard.​

This review studied the metabolic signaling roles of fructose versus glucose in modern diets and their links to metabolic disease and other outcomes. It reports that fructose acts as a signal of metabolic plenty, promoting triglyceride synthesis and fat accumulation under chronic overnutrition, thereby driving features of metabolic syndrome and being increasingly implicated in cancer and dementia. The significance is that it frames fructose as a distinct metabolic hazard beyond simple caloric excess, informing risk assessment and potential dietary interventions.

Johnson RJ, Lanaspa MA, Tolan DR et al. · Nature metabolism · (2026) · View on PubMed ↗

Oral microbiome signatures predict biological age and host health.​

This study evaluated whether oral microbiome composition can serve as a quantitative biomarker of biological age and health by analyzing oral microbiome data from two NHANES cohorts (N=4,675) and validating in an external cohort (N=1,293) using machine learning. It identified 64 age-dependent bacterial genera, trained a model to predict chronological age, and defined an Oral Microbiome Aging Acceleration (OMAA) score that independently associated with all-cause mortality and frailty. These results support oral microbiome signatures as non-invasive predictors of healthspan-related outcomes.

Zhao JJ, Hu M, Li S et al. · Nature communications · (2026) · View on PubMed ↗

Dual Roles of Adipose Tissue in Skeletal Muscle Regeneration: Pro-Regenerative Versus Maladaptive.​

This review synthesized evidence on how adipose tissue can either promote or impair skeletal muscle regeneration depending on context, focusing on the regenerative microenvironment. The key finding was that appropriately regulated adipose presence supports metabolic support and paracrine signaling during repair, whereas excessive or dysregulated ectopic fat accumulation drives maladaptive regeneration and persistent functional impairment. Scientifically and clinically, it frames adipose modulation as a potential therapeutic target to improve outcomes in muscle repair and sarcopenia-related conditions.

Lu C, Lu F, Cai J · Journal of cachexia, sarcopenia and muscle · (2026) · View on PubMed ↗

Sarcopenic Obesity in Children: An Emerging Complication Evidenced by Clinical Data and a Juvenile Mouse Model.​

This study investigated sarcopenic obesity in children by combining clinical assessments in 1447 children (DXA body composition; grip strength in a separate cohort of 349) with a juvenile mouse model of high-fat diet (HFD)-induced obesity. The key finding was that childhood obesity was associated with impaired musculoskeletal health consistent with sarcopenic obesity, and mechanistic analyses in juvenile versus adult-onset HFD models implicated underlying molecular pathways affecting muscle development. The work highlights sarcopenic obesity as an emerging pediatric complication and provides a translational preclinical framework for mechanism-driven interventions.

Wang S, Zhang W, Qin Z et al. · Journal of cachexia, sarcopenia and muscle · (2026) · View on PubMed ↗

Long-term effects of plant vs. animal protein supplementation on body composition, muscle strength, physical performance, and cardiometabolic risk factors in adults:a systematic review and meta-analysis of randomized controlled trials.​

This systematic review and meta-analysis studied long-term (≥6 months) supplementation with plant-based protein (PBP) versus animal-based protein (ABP) in adults, focusing on body composition, muscle strength, physical performance, and cardiometabolic risk factors using randomized controlled trials. The key finding is the pooled comparative effect of PBP vs ABP on these outcomes over extended durations (with effect sizes and confidence intervals extracted from included trials). Clinically, it informs dietary protein-source decisions for adults aiming to improve musculoskeletal and cardiometabolic health over the long term.

Yimam MA, Roberts J, O'Callaghan A et al. · Frontiers in nutrition · (2026) · View on PubMed ↗

Latest advances and controversies of exercise therapy in the management of type 2 diabetes.​

This mini-review studied exercise therapy for type 2 diabetes, synthesizing recent evidence on exercise modalities, dosing, and the gap between ideal efficacy and real-world effectiveness. It reports that high-intensity interval training (HIIT) is time-efficient and is associated with superior reductions in glycated hemoglobin (HbA1c), while concurrent training (aerobic plus resistance) provides the broadest metabolic benefits. Clinically, it supports tailoring exercise prescriptions toward HIIT or combined aerobic-resistance programs to maximize glycemic and overall health outcomes in type 2 diabetes.

Hao J, Zhang H · Frontiers in endocrinology · (2026) · View on PubMed ↗

GLP-1/obesity & adverse effects​

Effects of GLP-1 Receptor Agonists on Muscle Mass, Strength, and Quality in MASLD: A Systematic Review.​

This systematic review studied how GLP-1 receptor agonists (GLP-1RAs) affect muscle mass, strength, and muscle quality in adults with metabolic dysfunction-associated steatotic liver disease (MASLD) by including interventional and observational studies up to December 2, 2025. It assessed muscle outcomes using imaging and body-composition techniques such as computed tomography or MRI, dual-energy X-ray absorptiometry, and bioelectrical impedance analysis. The review is clinically relevant because it clarifies whether GLP-1RA–driven weight loss in MASLD compromises or preserves skeletal muscle health, which is crucial for patient function and frailty risk.

Iorra F, Jayakar T, Yee M et al. · Liver international : official journal of the International Association for the Study of the Liver · (2026) · View on PubMed ↗

GLP-1 therapies and hair loss: A systematic review of current evidence and implications for counseling.​

This systematic review studied GLP-1 receptor agonist–specific associations with hair loss by screening 133 studies and including 24 primary articles that reported alopecia outcomes related to GLP-1 RA use. It found that semaglutide and tirzepatide showed the highest incidence rates and strongest pharmacovigilance signals for hair loss, with characterization of alopecia subtypes and discussion of potential mechanisms. The evidence is important for clinicians to counsel patients starting GLP-1 therapies about the risk of alopecia and to monitor/manage this adverse effect.

Gupta AK, Teasell EM, Economopoulos V et al. · Science progress · (2026) · View on PubMed ↗

Microbiome & gut–immune/metabolic axes​

Lactate metabolism-driven lactylation: paradoxical modulation of intestinal inflammation and malignancy.​

This review studied lactate metabolism-driven lactylation as a mechanism that can paradoxically modulate both intestinal inflammation and malignancy. It summarized how lactate-dependent lactylation (an epigenetic modification) links metabolic state to immune and cancer-related pathways, framing lactate metabolism/lactylation as potential therapeutic targets. The scientific significance is that it provides a mechanistic rationale for developing interventions that manipulate lactate signaling to treat gut inflammatory disease and intestinal cancers.

Liu J, Liu Y, Zhang H et al. · Journal of translational medicine · (2026) · View on PubMed ↗

Faecalibacterium prausnitzii enzyme reprograms PD-L1 trafficking and sensitizes colorectal cancer to immunotherapy in mice.​

This study examined how the gut bacterium Faecalibacterium prausnitzii and its enzyme phosphoribosyl pyrophosphate synthetase (fpPRPS) affect PD-L1 trafficking and immunotherapy response in colorectal cancer (CRC) using CRC patient cohort analyses, in vitro assays, and azoxymethane/dextran sulfate sodium (AOM/DSS) and Apcmin/+ mouse CRC models. F. prausnitzii extracts (via fpPRPS) inhibited tumor development and sensitized CRC to immunotherapy by reprogramming PD-L1 trafficking. These findings suggest a microbiome-derived, enzyme-specific mechanism that could be leveraged to improve CRC immunotherapy efficacy.

Ji S, Liu Y, Xu Y et al. · Nature microbiology · (2026) · View on PubMed ↗

Re-establishing bile acid composition after treatment of recurrent Clostridioides difficile infection with fecal microbiota transplantation compared with oral vancomycin or a 12-strain bacterial mixture.​

In a subgroup of a randomized controlled trial in patients with recurrent Clostridioides difficile infection, fecal bile acid composition was longitudinally assessed after fecal microbiota transplantation (FMT) versus an oral vancomycin control or a 12-strain bacterial mixture, using fecal bile acid profiling and 16S rDNA sequencing. FMT more effectively re-established a bile acid composition closer to a “normal” profile than vancomycin or the 12-strain mixture, supporting bile acid normalization as a treatment-relevant mechanism. This controlled evidence strengthens the scientific rationale for targeting bile acid ecology to improve outcomes in recurrent C. difficile infection.

Rode AA, Duboc H, Lamazière A et al. · Gut microbes · (2026) · View on PubMed ↗

Intestinal dysbiosis exacerbates skin inflammation via microbial metabolite-driven Th2 cell differentiation.​

In mice and in human atopic dermatitis (AD) patients, the study tested how intestinal dysbiosis drives skin inflammation through microbial metabolite-driven Th2 differentiation, using Toll-like receptor 4 (TLR4) epithelial deficiency as a mechanistic perturbation. TLR4 deficiency reshaped the microbiome by reducing Akkermansia muciniphila and enriching CutC-expressing bacteria, increasing choline-to-trimethylamine conversion and circulating TMAO, which promoted Th2 differentiation and worsened AD-like inflammation. The finding that plasma TMAO levels were elevated in AD patients and correlated with severity links a specific gut microbial metabolic axis to human disease activity.

Yu L, Peng S, Chen X et al. · Immunity · (2026) · View on PubMed ↗

A bidirectional brain-fat body axis for pathogen avoidance.​

In Drosophila melanogaster, this study identified a bidirectional fat body–brain communication pathway that mediates pathogen avoidance, using immune receptor and antimicrobial peptide requirements in both tissues. Pathogen sensing in octopaminergic neurons activated fat body calcium signaling via an octopamine receptor, triggering fat body dopamine release that acted through Dop1R1 in the brain to suppress pathogen intake. The work clarifies how peripheral immune detection is translated into coordinated behavioral avoidance through defined neuromodulators.

Wang Y, De Backer JF, Muria A et al. · Neuron · (2026) · View on PubMed ↗

Improving immunotherapy in solid tumors using FMT.​

This article reviewed clinical evidence that fecal microbiota transplantation (FMT) is used to improve first-line immune checkpoint inhibitor efficacy in patients with solid tumors, focusing on renal cell carcinoma, cutaneous melanoma, and non-small cell lung cancer. The key finding is that FMT benefits appear driven by functional microbiome remodeling, depletion of deleterious taxa, and systemic immunometabolic modulation that enhances anti-tumor immune responses. This supports microbiome-directed therapeutic strategies—specifically FMT—to augment immunotherapy outcomes in multiple solid-tumor settings.

Davar D, Zarour HM, Trinchieri G · Cell · (2026) · View on PubMed ↗

Mitochondrial translation elongation controls OXPHOS biogenesis by coordinating synthesis and folding of mitochondrially encoded proteins.​

This study investigated how mitochondrial translation elongation regulates oxidative phosphorylation (OXPHOS) biogenesis in the fungus Neurospora crassa, centering on the mitochondrial ribosomal RNA (rRNA) methyltransferase 1 (MRM1) gene. The key finding is that MRM1 promotes OXPHOS biogenesis by repressing mitochondrial translation elongation through RNA–ribosome interactions mediated by its N-terminal intrinsically disordered region, independently of its catalytic activity. Scientifically, it identifies a non-enzymatic, interaction-based control point linking mitochondrial translation dynamics to mtDNA-encoded respiratory protein production.

Xie L, Ren S, Zhang L et al. · Molecular cell · (2026) · View on PubMed ↗

Effect of Probiotics on the Clinical Outcome and Inflammatory Response in Gastric Cancer Surgery: A Double Blinded Randomized Control Trial.​

This double-blind randomized placebo-controlled trial studied whether probiotics improve postoperative outcomes and inflammatory/immune responses in gastric cancer patients undergoing open gastrectomy. The key finding is that probiotic administration (10 days, per the abstract) was evaluated for effects on length of hospital stay, nutritional status, and postoperative inflammatory and immune markers compared with placebo. Clinically, the trial tests whether gut microbiota modulation can reduce postoperative complications and immune dysfunction in gastric cancer surgery patients.

Pal D, Anandhi A, Keerthi AR et al. · Journal of gastrointestinal cancer · (2026) · View on PubMed ↗

Pharmacological interventions targeting the gut-brain axis in neurological disorders: mechanisms and translational applications.​

This article reviewed pharmacological interventions that target the gut–brain axis in neurological disorders, focusing on mechanistic pathways linking microbiota changes to brain outcomes. The key finding was that gut microbiota–gut–brain communication can modulate neuroinflammation, neurotransmission, and blood–brain barrier integrity through neural, immune, endocrine, and metabolic routes, supporting translational therapeutic concepts. Scientifically, it consolidates evidence for gut–brain axis modulation as a strategy for neurological and psychiatric disease treatment development.

Li X, Zhou W, Yang S et al. · Frontiers in neuroscience · (2026) · View on PubMed ↗

Cancer cell death & tumor vulnerabilities​

PRMT5 inhibition sensitizes B-cell lymphoma cells to ferroptosis.​

This study examined whether inhibiting PRMT5 affects ferroptosis sensitivity in B-cell lymphoma cell models, including diffuse large B-cell lymphoma (DLBCL) and mantle cell lymphoma (MCL). It found that PRMT5 inhibition sensitizes these lymphoma cells to ferroptosis by upregulating SLC7A11 (cystine import for glutathione biosynthesis) through an AKT–MYC–ATF5 signaling axis. The clinical significance is that targeting PRMT5 may be a therapeutic strategy to trigger ferroptotic cell death in PRMT5-overexpressing B-cell lymphomas.

Liu Y, Chen R, Gao X et al. · Leukemia · (2026) · View on PubMed ↗

Programmed cell death in lung cancer: mechanisms, immune responses, and therapeutics.​

This review studied programmed cell death (PCD) pathways in lung cancer, covering apoptosis, pyroptosis, ferroptosis, and necroptosis and their interactions with immune responses and therapies. It concludes that PCD mechanisms shape tumor immune microenvironments and influence resistance or responsiveness to treatments such as immune checkpoint blockade and cytotoxic chemotherapy. The significance is that understanding these PCD pathways can guide development of combination or next-generation therapeutics that overcome immune evasion in lung cancer.

Liu Y, Chen Q, Xu J et al. · Apoptosis : an international journal on programmed cell death · (2026) · View on PubMed ↗

FAAH initiates a positive feedback loop to promote lung adenocarcinoma progression through inhibition of ferroptosis.​

This study investigated fatty acid amide hydrolase (FAAH) as a regulator of ferroptosis in lung adenocarcinoma (LUAD) by analyzing LUAD patient data and manipulating FAAH in LUAD cells. FAAH was upregulated in LUAD and promoted a positive feedback loop that inhibited ferroptosis by enhancing STAT3 palmitoylation through conversion of N-palmitoylethanolamine to palmitic acid. Targeting FAAH may therefore restore ferroptotic cell death and provide a therapeutic strategy for LUAD.

He X, Tang C, Jiang T et al. · Cell death and differentiation · (2026) · View on PubMed ↗

Cell death in cancer.​

This review examined how cancer cells evade cell death and how restoring cell death requires understanding multiple cell-death programs beyond apoptosis, including necroptosis, pyroptosis, ferroptosis, and other emerging pathways. It finds that while apoptosis remains the dominant program induced by radiation and many chemotherapies, non-apoptotic death programs can drive inflammation and modulate tumor–stroma–immune interactions that influence immunotherapy outcomes. The significance is that targeting specific cell-death pathways could improve therapeutic efficacy and reshape immune responses in cancer treatment.

Conrad M, Strasser A, Jost PJ et al. · Cell · (2026) · View on PubMed ↗

Rational Design of Schiff Base Copper Chelators as Potent Necroptosis Inducers for Anticancer Therapy.​

The study designed and tested novel Schiff base copper chelators to induce necroptosis for anticancer therapy, evaluating their activity in cancer models relevant to “copper addiction.” The key finding was that rational structural modifications of Schiff base ligands produced potent, copper-specific chelators that trigger necroptosis more effectively than less optimized chelation approaches. This supports a drug-design strategy that exploits tumor copper dependence to drive programmed necrotic cell death as a potential anticancer mechanism.

Yu LB, Guan QX, Huang ST et al. · Journal of medicinal chemistry · (2026) · View on PubMed ↗

Cancer immunotherapy & tumor microenvironment​

NKG2A inhibition promotes NK cell-CD8+ T cell interactions to improve anticancer immunity in ovarian carcinoma.​

This study characterized NK-cell heterogeneity and its impact on NK–CD8+ T cell interactions in ovarian carcinoma, focusing on NKG2A expression, using transcriptomic and spatial profiling of patient samples plus functional experiments in syngeneic mouse models. High-grade serous ovarian carcinoma (HGSOC) contained dysfunctional NK cells expressing the co-inhibitory receptor NKG2A, and inhibiting NKG2A improved anticancer immunity by promoting reciprocal activation between NK cells and CD8+ T cells. Clinically, NKG2A blockade could enhance coordinated NK–T cell responses in HGSOC.

Lanickova T, Angelidou A, Hensler M et al. · Nature communications · (2026) · View on PubMed ↗

Identification of cycling regulatory T cell precursors as conductors of immune escape during breast carcinoma progression.​

The study used transcriptomic mapping of immune landscapes across normal breast, ductal carcinoma in situ (DCIS), and invasive breast cancer (IBC) cohorts, and then tested mechanisms in a rat breast cancer model to define cycling regulatory T cell (cycTreg) roles during DCIS-to-IBC progression. Cycling regulatory T cells were identified as an orchestrator of immunosuppression in IBC, with cycTreg frequency predicting cytotoxic CD8+ T-cell features, TCR diversity, disease-specific survival in IBC, and recurrence in DCIS. These findings suggest cycTreg precursors drive immune escape and could serve as prognostic biomarkers and therapeutic targets to improve outcomes in breast cancer progression.

Bui TM, Jimenez ER, Li Z et al. · Cancer cell · (2026) · View on PubMed ↗

Unlocking the potential of T cell engagers in solid tumors.​

This article reviewed the development and clinical design principles of T cell engagers (TCEs) for solid tumors, focusing on challenges such as tumor target heterogeneity, immunosuppressive microenvironments, and on-target toxicity. It concludes that improved target selection, creative protein engineering, and thoughtful clinical trial design are central to overcoming these barriers for next-generation solid-tumor TCEs. The work is significant because it frames how to translate TCE success from hematologic malignancies into safer, more effective solid-tumor immunotherapies.

Wingrove E, Bailis JM, Farago AF et al. · Cancer cell · (2026) · View on PubMed ↗

Mapping intratumor heterogeneity across layers for advancing immunotherapy.​

The study reviewed and conceptually integrated approaches to map intratumor heterogeneity (ITH) across multiple layers—genetic, epigenetic, transcriptional, proteomic, and immunopeptidomic—linking these layers to immune recognition. It highlights that variation in antigen processing and peptide abundance across tumor clones and cell states creates spatially and temporally distinct immunological niches that shape immunotherapy responses. This is significant because it motivates immunotherapy development strategies that target not just mutations but also dynamic antigen presentation and immunopeptidome heterogeneity.

Marine JC, Bartok O, Sagie S et al. · Cell · (2026) · View on PubMed ↗

Combinatorial delivery of low-dose radiotherapy and immunotherapy to patients with immune-excluded tumors enhances CD8+ T cell functionality.​

In a multi-cohort phase I clinical trial (RACIN), 25 patients with multimetastatic immune-excluded solid tumors received low-dose radiotherapy (LDRT) combined with immune-based regimens including nivolumab plus ipilimumab and additional agents (aspirin or celecoxib) plus low-dose cyclophosphamide. The combinatorial LDRT plus immunotherapy approach enhanced CD8+ T cell functionality in these immune-excluded tumors. This provides clinical rationale for using LDRT to convert “cold” tumors into more immunologically responsive settings for checkpoint blockade.

Ochoa-de-Olza M, Rayroux N, Imbimbo M et al. · Clinical cancer research : an official journal of the American Association for Cancer Research · (2026) · View on PubMed ↗

Viral vector-free generation of orthogonal IL-2-responsive CAR T cells through gene editing of IL-2 and its receptor.​

This study investigated viral vector-free generation of orthogonal IL-2-responsive CAR T cells by gene editing IL-2 and its receptor, producing orthogonal IL-2Rβ (oIL-2Rβ) mutations in T cells via prime editing. The key finding is that prime editing achieved ~72% average efficiency, produced functional oIL-2Rβ that enriched with oIL-2, and improved CAR T-cell engraftment, efficacy, and toxicity in vivo comparably to conventional cotransduction approaches. Scientifically, it demonstrates a safer manufacturing route for orthoCAR T cells and shows that IL-2 pathway orthogonalization can be engineered to enhance therapeutic performance.

Zhang Q, Wu Y, Yang J et al. · Blood immunology & cellular therapy · (2025) · View on PubMed ↗

One-step knock-in CAR constructs in human NK cells enable scalable, TGFβ1-resistant immunotherapy for solid tumors.​

Researchers engineered primary human NK cells using a one-step electroporation delivery of Cas9 ribonucleoprotein plus a dsDNA donor to knock out TGFBR2 and knock in a mesothelin CAR, and compared performance against a two-step AAV approach with dexamethasone (Dex) used during manufacturing. The key finding is that this scalable one-step knock-in strategy yields TGFβ1-resistant CAR-NK cells with enhanced anti-solid-tumor activity despite TGFβ-mediated immunosuppression in the tumor microenvironment. Clinically, this supports a practical manufacturing route for CAR-NK therapies targeting mesothelin-positive solid tumors while overcoming a major resistance mechanism driven by TGFβ signaling.

Yee SM, Jeong JH, Kim D et al. · Theranostics · (2026) · View on PubMed ↗

Cancer genomics/epigenetics & DNA damage​

Tools and tactics for studying alternative splicing.​

This review studied how alternative splicing is mapped and functionally tested across model systems, emphasizing recent advances in long-read sequencing, CRISPR-based splicing assays, population genetics, and deep learning approaches. It reports that long-read sequencing now enables isoform-resolved profiling at bulk, single-cell, and spatial levels, while CRISPR perturbations can directly test the functional impact of specific splicing isoforms. These developments are significant because they accelerate mechanistic discovery of splicing dysregulation in diseases such as rare genetic disorders and cancer and improve the ability to interpret splicing “language” from sequence.

Sousa-Luís R, Carmo-Fonseca M · Nature reviews. Genetics · (2026) · View on PubMed ↗

MRE11 proximal polyadenylation site-mediated looping impacts transcription and genomic stability.​

Researchers studied how the proximal polyadenylation site (pPAS) of the DNA damage response gene MRE11 regulates transcription and genome stability by enabling PAS-promoter looping and RNA polymerase recycling. Deleting the MRE11 pPAS disrupted looping, reduced MRE11 transcription and MRN complex (MRE11-RAD50-NBS1) levels, and caused ectopic DNA replication with reduced viability under overgrowth conditions, phenocopying hypomorphic MRE11 mutations. This mechanistic link between alternative polyadenylation control and DDR function identifies a new regulatory layer for maintaining genomic stability.

Huang K, Brault ME, Cong K et al. · Molecular cell · (2026) · View on PubMed ↗

A recipe for chaos: Extrachromosomal DNA and the hallmarks of cancer.​

This article reviewed evidence that extrachromosomal DNA (ecDNA) contributes to rapid genome change and therapy resistance in aggressive cancers by enabling oncogenic elements to evolve outside Mendelian inheritance. It proposes integrating ecDNA biology into the hallmarks of cancer framework to identify ecDNA-specific vulnerabilities distinct from conventional mutation-targeting approaches. The significance is that ecDNA may represent a mechanistic driver of genomic chaos and a new therapeutic entry point for resistant cancers.

Wong IT, Bailey C, Wu S et al. · Cell · (2026) · View on PubMed ↗

Targeting genomic instability in cancer.​

This review summarized how genomic instability both fuels cancer evolution and creates therapeutic vulnerabilities, and it traced how targeting it has evolved from chemotherapy and external beam radiation to PARP inhibitors in homologous recombination repair-deficient tumors and other DNA damage response targets. It also highlights newer tumor-targeted DNA-damaging modalities, including antibody-drug conjugates (ADCs) and radiopharmaceuticals, as emerging strategies. The clinical significance is that exploiting genomic instability can improve treatment selectivity and effectiveness, particularly in DNA repair–defective or instability-high tumors.

Yap TA, Manning HC, Sapra P et al. · Cell · (2026) · View on PubMed ↗

Decoding RNA splicing pathology: Alternative splicing in amyotrophic lateral sclerosis and its therapeutic potential.​

This article reviewed RNA splicing pathology in amyotrophic lateral sclerosis (ALS), emphasizing therapeutic implications of dysregulated alternative splicing controlled by genes such as TARDBP, FUS/EWSR1/TAF15 (FET family), SOD1, and C9orf72. The key finding is that mutations or mislocalization of these RNA-processing proteins produce nuclear loss-of-function and cytoplasmic gain-of-function toxicity, promoting splicing defects and downstream neurodegeneration. The scientific significance is that splicing-regulatory pathways and specific ALS genes represent rational targets for developing mechanism-based therapies.

Priya R, Tanti GK, Jain BP · Biochemical and biophysical research communications · (2026) · View on PubMed ↗

Cancer signaling & metastasis mechanisms​

Integrative single-cell analysis reveals endothelial diversity in the vasa vasorum of human atherosclerosis.​

This study used integrative single-cell RNA sequencing to characterize endothelial diversity in the vasa vasorum associated with human atherosclerosis. By integrating five scRNA-seq datasets (17,367 vascular endothelial cells) and validating morphology histologically, it identified SULF1+ arterial endothelial cells as a major EndMT-associated subcluster and capillary-like endothelial cells as key mediators of angiogenesis, with a trajectory model describing tip-to-stalk transitions. The significance is that it provides a cell-type-resolved map of endothelial programs in atherosclerotic microvessels, highlighting targets linked to EndMT and angiogenesis.

Wu Y, Xue Z, Sun T et al. · Communications biology · (2026) · View on PubMed ↗

ELMO2 is a therapeutic vulnerability in mesenchymal-like and drug-resistant non-small cell lung cancer.​

This study tested whether ELMO2 is a therapeutic vulnerability in mesenchymal-like and drug-resistant non-small cell lung cancer (NSCLC) by suppressing ELMO2 and assessing autophagy/cell death pathways, including FAK activity, in relevant NSCLC models. ELMO2 suppression induced excessive autophagy and cell death through FAK inhibition, and ELMO3 acted as a compensatory paralog creating a synthetic lethal interaction with ELMO2 loss. Because ZEB1 repressed ELMO3 transcription in mesenchymal-like cells, ZEB1-high states may be particularly sensitive to ELMO2-targeted blockade.

Li M, Xue Y, Chang Y et al. · Nature communications · (2026) · View on PubMed ↗

Aberrant laminin signaling drives melanocyte dedifferentiation and unveils a tractable therapeutic target in vitiligo.​

This study investigated how aberrant laminin signaling drives melanocyte dedifferentiation in vitiligo by comparing healthy skin and vitiligo tissue microenvironments and analyzing basement-membrane niche changes. In vitiligo, reduced laminin-211 and increased laminin-332 shifted melanocyte interactions toward integrin α3β1–laminin-332, accompanied by Rho–F-actin remodeling and coordinated pathway changes consistent with a dedifferentiation-like, potentially reversible state. The work identifies tractable targets within laminin–integrin signaling that may be exploited to treat or reverse vitiligo progression.

Yang F, Yang L, Lai S et al. · Nature communications · (2026) · View on PubMed ↗

Cancer cachexia: A tumor-driven disorder of whole-body homeostasis.​

The article synthesized evidence on cancer cachexia as a tumor-driven systemic disorder affecting whole-body homeostasis, emphasizing mechanisms spanning immune, metabolic, endocrine, and neural networks. It highlights that cachexia—marked by skeletal muscle atrophy and adipose tissue loss—reduces function and quality of life, impairs treatment tolerance, and worsens survival across multiple cancers. Clinically, this underscores the need for mechanistically informed therapies to prevent or reverse cachexia and improve cancer treatment outcomes.

Zhang Y, Nipp RD, Janowitz T et al. · Cancer cell · (2026) · View on PubMed ↗

Hallmarks of liver cancer: Therapeutic implications.​

This review analyzed how the cancer hallmarks framework applies to primary liver cancer, particularly hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (iCCA), and discussed therapeutic implications. It reports that HCC commonly exhibits hallmarks such as sustaining proliferative signaling, accessing vasculature, and avoiding immune detection, with improved outcomes in advanced disease driven by immunotherapies, while iCCA shows distinct hallmark patterns including proliferative signaling and other pathway features. The significance is that mapping liver cancer biology to hallmarks can guide rational selection and combination of targeted and immunotherapeutic strategies.

Llovet JM, Pinyol R, Affo S et al. · Cell · (2026) · View on PubMed ↗

Spatial Mapping of the Precancer-to-Cancer Transition in Breast and Prostate.​

This work studied the precancer-to-cancer transition in breast and prostate hormone-driven adenocarcinomas using lightsheet microscopy on intact tumors and a multimodal serial-section workflow combining volumetric reconstruction with spatial transcriptomics across 51 cases. The key finding is that transitional junctions between precancerous and invasive regions show distinct gene-expression programs, including breast associations with loss of MGP and PLAT and prostate associations with GDF15, ALDH1A3, ANPEP, and FA (as reported in the abstract). Clinically, mapping these spatial molecular shifts can reveal actionable drivers of invasion and improve understanding of how local tissue architecture and gene regulation jointly enable malignancy progression.

Storrs E, Mo CK, Chou WH et al. · Cancer discovery · (2026) · View on PubMed ↗

UFMylation Suppresses Hepatocellular Carcinoma Metastasis by Inhibiting β-catenin-Driven Hybrid EMT and NK Cell Evasion.​

This study analyzed human hepatocellular carcinoma (HCC) specimens and mechanistically tested how ubiquitin-fold modifier 1 (UFM1) conjugation (UFMylation) affects metastasis and immune evasion, identifying Emerin (EMD) as a UFMylation substrate. The key finding is that reduced UFMylation destabilizes EMD via proteasomal degradation, leading to nuclear β-catenin accumulation, hybrid epithelial–mesenchymal transition (EMT), enhanced tumor migration, and NK cell evasion. Clinically, UFMylation status may serve as a prognostic marker and a potential therapeutic lever to suppress HCC metastasis and improve anti-tumor immunity.

Xu M, Gao X, Zhao J et al. · Cancer research · (2026) · View on PubMed ↗

Targeting Tumour Microtubes to Disrupt Glioma Networks.​

This study investigated glioma stem cells (GSCs) and their tumor microtubes (TMs) that enable glioma network communication, using coordinated proteomics and functional screening in glioma models. It identified the inner mitochondrial component FASTKD2 as essential for TM-local protein synthesis, and showed that targeting FASTKD2 reduces tumor stemness and growth by disrupting coordinated mitochondrial support of TM-mediated signaling. Scientifically and therapeutically, FASTKD2 emerges as a mechanistic vulnerability to break glioma networks and potentially overcome therapy resistance driven by TM connectivity.

Rich J, Huang T, Zhang P et al. · Research square · (2026) · View on PubMed ↗

Single-Cell Transcriptomics Reveals Riluzole as an Osteoarthritis Candidate Drug via OB-NE Signaling Modulation and CTSS/NOS1 Inhibition.​

This study used single-cell RNA sequencing of human femoral head tissue to identify osteoarthritis (OA) drug candidates, applying integrated bioinformatics (differential expression, enrichment, and cell–cell communication analysis), network-proximity drug repositioning, and Mendelian randomization (MR) to test causal links between drug targets and OA; it then evaluated effects in a triclocarban (TCC)-induced zebrafish OA model. The key finding is that riluzole emerges as an OA candidate drug via modulation of OB–NE (osteoblast–immune cell) signaling and inhibition of CTSS and NOS1. The significance is a target- and pathway-informed repositioning of riluzole for OA with mechanistic support from human single-cell data and in vivo disease modeling.

Liu K, Li JL, Chen Y et al. · Drug design, development and therapy · (2026) · View on PubMed ↗

WNT5a-Mediated Aberrant Actin Filament Dynamics Drive Cardiac Pathogenic Phenotypes in LMNA-Related Emery-Dreifuss Muscular Dystrophy.​

This Circulation study investigated LMNA-related Emery-Dreifuss muscular dystrophy (EDMD) by recruiting five patients with LMNA sequence variations, generating patient-specific induced pluripotent stem cells (iPSCs), and examining how WNT5a-mediated actin filament dynamics drive cardiac pathogenic phenotypes. The key finding is that WNT5a signaling aberrantly alters actin filament dynamics, contributing to disease-relevant cardiac abnormalities in LMNA-EDMD. Scientifically and clinically, it links a specific signaling–cytoskeleton mechanism to LMNA cardiomyopathy and suggests WNT5a/actin pathway modulation as a potential therapeutic direction.

Fan H, Wang X, Liu X et al. · Circulation · (2026) · View on PubMed ↗

Neurodegeneration & brain biomarkers​

Dysfunction of the episodic memory network in the Alzheimer's disease cascade.​

This study examined episodic memory (EM) network dysfunction across Alzheimer’s disease (AD) progression by analyzing longitudinal functional MRI data from the DZNE DELCODE study (>1,000 measurements) and relating EM activation/deactivation to disease progression model scores. With increasing AD biomarker and neurodegeneration progression, voxel-wise analyses showed widespread loss of EM deactivation and activation, with nonlinear trajectories for deactivation loss. These findings link EM network breakdown to the AD cascade and may help refine biomarkers for tracking disease progression.

Lattmann R, Vockert N, Bernal J et al. · Nature communications · (2026) · View on PubMed ↗

Night-to-night rapid eye movement sleep variability: A relevant marker of early amyloid-β deposition.​

This study examined cognitively unimpaired older adults with cerebral amyloid deposition to determine whether night-to-night rapid eye movement (REM) sleep variability predicts early amyloid-β (Aβ) deposition, using objective multi-night sleep monitoring with the Somno-Art wearable device and Florbetapir PET. The key finding is that Aβ-positive individuals show altered sleep patterns, with REM sleep variability associated with regional amyloid deposition and related cognitive/psychoaffective outcomes (as summarized in the abstract). Scientifically and clinically, it suggests a noninvasive sleep biomarker that may help detect early AD pathology before clinical symptoms.

Montagne B, Boulin M, Hamel A et al. · Alzheimer's & dementia : the journal of the Alzheimer's Association · (2026) · View on PubMed ↗

Elevated plasma klotho levels attenuate Alzheimer's disease pathologies and cognitive decline in APOE ε4 carriers.​

This study investigated whether elevated plasma klotho levels attenuate Alzheimer’s disease (AD) pathologies and cognitive decline in older adults stratified by apolipoprotein E (APOE) ε4 carrier status, analyzing 354 participants. The key finding is that higher plasma klotho is associated with lower AD-related biomarkers on imaging and/or plasma measures and with reduced cognitive decline, with APOE ε4-dependent relationships supported by stratified interaction and mediation analyses. The significance is that plasma klotho could be a modifiable or prognostic biomarker linked to AD risk specifically in APOE ε4 carriers.

Yang J, Wang J, Chai W et al. · Alzheimer's & dementia : the journal of the Alzheimer's Association · (2026) · View on PubMed ↗

Brain age gap as biomarker linking cardiovascular diseases genetic susceptibility and causality.​

This study used UK Biobank T1-weighted MRI to build a 3D vision transformer (3D-ViT) model that predicts brain age and computes brain age gap (BAG), then tested causal relationships between BAG and cardiovascular disease (CVD) using bidirectional Mendelian randomization. The key finding was evidence of brain–heart interactions, with acute myocardial infarction (AMI) and chronic ischemic heart disease (CIH) associated with decelerated brain aging in the causal framework. This is significant because BAG may serve as an imaging-derived biomarker linking genetic susceptibility and causality to systemic aging risk in CVD.

Lyu S, Zhang R, Peng K et al. · iScience · (2026) · View on PubMed ↗

Voxel-accurate MRI-microscopy Correlation Enables AI-powered Prediction of Brain Disease States.​

This study investigated how to map MRI signals to cellular-level biological ground truth by developing BRIDGE, a platform integrating in vivo MRI with in vivo two-photon microscopy and ex vivo super-resolution microscopy. The key finding is that BRIDGE enables voxel-accurate, longitudinal co-registration so that MRI signal origins can be linked to cellular/anatomical features, enabling AI training on these ground-truth mappings. This is significant because it can improve AI-powered prediction of brain disease states by grounding imaging biomarkers in biological mechanisms.

Schroers J, Yang Y, Reyhan E et al. · Theranostics · (2026) · View on PubMed ↗

Neuroimmunology & neuroinflammation therapeutics​

Cancer neuroscience: The past, the present, and the road ahead.​

This perspective reviewed how cancer neuroscience—bidirectional neuro–cancer interactions—affects cancer initiation, growth, metastasis, and treatment resistance, and how cancer can reprogram neural circuits to produce neuropsychiatric symptoms. It emphasizes that understanding mechanisms such as neuron-to-cancer synapses and neuro–immuno-oncological paracrine interactions could enable “neuroscience-instructed” cancer therapies. The scientific significance is a roadmap for integrating neural biology with oncology to improve disease control and patient quality of life.

Winkler F, Heuer S, Althammer F et al. · Cell · (2026) · View on PubMed ↗

CAR Treg therapies for neurodegenerative diseases.​

This article reviews how chimeric antigen receptor regulatory T cells (CAR Tregs) are being explored for neurodegenerative diseases, focusing on Treg biology and their potential to recognize immune triggers from misfolded/aggregated self-proteins in the CNS. It highlights the concept that CAR Tregs could be engineered to suppress chronic immune responses driven by protein aggregates that contribute to neural injury. If translated successfully, CAR Treg targeting of aggregation-associated antigens could provide a cell-specific immunotherapy strategy to slow or prevent neuroinflammation-driven progression in neurodegenerative disorders.

Stein DN, Gendelman HE · iScience · (2026) · View on PubMed ↗

Meningeal macrophages regulate fibroblasts to influence meningeal lymphatic function following traumatic brain injury.​

This study examined how meningeal macrophages regulate fibroblasts to influence meningeal lymphatic function after traumatic brain injury (TBI), using single-cell RNA sequencing, confocal microscopy, and flow cytometry. It identified a distinct meningeal fibroblast population that secretes VEGF-C and showed that manipulating macrophage–fibroblast signaling (including via clodronate liposomes and PDGF-C interventions) alters meningeal lymphatic function following TBI. Clinically, it suggests a macrophage-driven VEGF-C fibroblast axis as a potential therapeutic target to restore lymphatic clearance and immune trafficking after TBI.

Guo X, Zhu Y, Gao S et al. · Theranostics · (2026) · View on PubMed ↗

Nuclear export modulates TDP-43 phase transitions and cytoplasmic aggregation.​

This study investigated how nuclear export regulates TAR DNA-binding protein 43 (TDP-43) phase transitions and cytoplasmic aggregation using chemical and genome-wide genetic screening in cells expressing an RNA-binding–defective TDP-43 mutant that models an ALS-associated variant. The key finding is that multiple cellular processes—including RNA splicing, protein translation, proteostasis imbalance, and nuclear export—modulate the liquid-to-solid phase transition and aggregation behavior of TDP-43. The significance is identifying nuclear export as a controllable regulator of TDP-43 pathology, offering potential targets for therapeutic intervention in ALS and related neurodegenerative diseases.

Chin N, Zhang Q, Zou J et al. · bioRxiv : the preprint server for biology · (2026) · View on PubMed ↗

Fibrosis & inflammatory lung disease​

Hdac11 promotes idiopathic pulmonary fibrosis through macrophage M2-type polarization and myofibroblast accumulation by inhibiting Parkin-dependent mitophagy.​

This study assessed the role of histone deacetylase 11 (Hdac11) in idiopathic pulmonary fibrosis (IPF) by analyzing Hdac11 expression in IPF lungs and using genetic ablation and adoptive transfer of Hdac11-deficient macrophages. Hdac11 upregulation in alveolar macrophages promoted M2 macrophage polarization and macrophage-to-myofibroblast transition-like reprogramming, leading to increased myofibroblast accumulation and profibrotic gene expression, whereas Hdac11 deficiency markedly attenuated fibrosis. Mechanistically, the study implicated impaired Parkin-dependent mitophagy as a driver of the anti-fibrotic effect, positioning Hdac11 as a potential therapeutic target in IPF.

Nie Y, Xu L, Liu Y et al. · Nature communications · (2026) · View on PubMed ↗

Hematologic malignancies & infections (HSCT/AML/lymphoma)​

Clinical and Microbiological Insights Into Invasive Fusariosis Following Allogeneic Hematopoietic Stem Cell Transplantation: A 15-Year Single-Center Analysis.​

This 15-year single-center retrospective analysis studied invasive fusariosis cases among 2,359 allogeneic hematopoietic stem cell transplant (HSCT) recipients for hematological malignancies (2010–2024), using multigene sequencing for Fusarium species identification and antifungal susceptibility testing. Seventeen proven invasive fusariosis cases (7.2/1000) were identified, with patients more often having prior HSCT and with high mortality despite prophylaxis and treatment. Clinically, the work highlights the need for heightened surveillance and optimized antifungal management strategies for Fusarium infection in post-allogeneic HSCT patients, especially those with prior transplant exposure.

Yamamoto J, Ogura S, Takagi S et al. · Transplant infectious disease : an official journal of the Transplantation Society · (2026) · View on PubMed ↗

The diagnostic and prognostic utility of blood metagenomic next-generation sequencing for invasive pulmonary aspergillosis.​

This retrospective study enrolled 95 patients with Aspergillus detected by blood fungal metagenomic next-generation sequencing (mNGS) and used modified EORTC/MSGERC criteria to distinguish invasive pulmonary aspergillosis (n=60) from colonization (n=35). It assessed diagnostic and prognostic utility of blood mNGS fungal load (reads per million) alongside serological biomarkers galactomannan (GM) and 1,3-β-D-glucan (BDG). If validated, combining blood mNGS fungal load with GM/BDG could improve clinical discrimination and risk stratification for IPA versus colonization.

Chen Y, Tang X, Lu S et al. · Microbiology spectrum · (2026) · View on PubMed ↗

Profiling medical mycologists: Results from a global survey of the ESCMID Fungal Infection Study Group (EFISG).​

This cross-sectional global survey characterized the medical mycology workforce using the ESCMID Fungal Infection Study Group (EFISG) as a representative international network. The study aimed to map training, roles, and research/education patterns among medical mycologists worldwide. Such workforce profiling can guide coordinated efforts to address invasive fungal infection burden, diagnostic gaps, and antifungal resistance.

Salmanton-García J, Lagrou K, Lanternier F et al. · Medical mycology · (2026) · View on PubMed ↗

Total marrow irradiation-based conditioning for allogeneic hematopoietic stem cell transplantation in patients with hematologic malignancies: A multicenter real-world study.​

This multicenter real-world study evaluated total marrow irradiation (TMI)-based conditioning for allogeneic hematopoietic stem cell transplantation (allo-HSCT) in patients with hematologic malignancies across four Chinese centers (2017–2024). The key finding was that TMI-based conditioning was feasible and associated with measurable overall survival and disease control outcomes, with safety assessed via nonrelapse mortality and graft-versus-host disease-related endpoints. Clinically, the large cohort strengthens evidence for TMI as a conditioning option in allo-HSCT outside tightly controlled trials.

Zhang Y, Zhang R, Cao X et al. · Cell transplantation · (2026) · View on PubMed ↗

Reproductive biology & infertility​

Biallelic mutations in ANAPC13 cause female infertility characterized by oocyte maturation arrest both in humans and mice.​

Researchers investigated biallelic ANAPC13 mutations in human patients with infertility and in mouse models to determine whether ANAPC13 loss causes oocyte maturation arrest, focusing on the anaphase-promoting complex/cyclosome (APC/C) pathway. ANAPC13 mutations produced oocyte maturation arrest in both humans and mice, phenocopying defects seen with other APC/C subunits. This establishes ANAPC13 as a causal gene for a specific ART-refractory infertility mechanism and informs genetic diagnosis and mechanistic understanding of meiotic progression failure.

Wang Y, Ding Z, Liu X et al. · American journal of obstetrics and gynecology · (2026) · View on PubMed ↗

Oxytocin signaling in adipocytes is required for normal milk fat production.​

This study examined the role of oxytocin signaling in adipocytes for milk fat production by using dams lacking oxytocin receptors specifically in adipose tissue (OxtrΔAd) and identifying the relevant oxytocin source. Adipocyte OXTR loss reduced milk triglycerides and impaired pup weight gain, and the effect was mediated by oxytocinergic sympathetic neurons; dietary fat supplementation rescued the triglyceride deficit. These results define a neuroendocrine (oxytocin–adipocyte) control of lactation that could inform interventions for impaired milk production.

Li E, Yuan Y, Sun H et al. · Cell metabolism · (2026) · View on PubMed ↗

Development of a DUX4-targeting antibody oligonucleotide conjugate as a therapy for FSHD.​

This preclinical/therapeutic development study created Delpacibart braxlosiran (del-brax/AOC 1020), an antibody–oligonucleotide conjugate designed to treat facioscapulohumeral muscular dystrophy (FSHD) by targeting DUX4 expression in skeletal muscle. The key finding was that the TfR1-targeted delivery of DUX4 mRNA–targeting siRNA (siDUX4.6) reduced DUX4 mRNA levels and demonstrated therapeutic activity consistent with effective muscle delivery. This is significant because it advances a targeted RNA-silencing strategy for FSHD by coupling gene-specific knockdown to receptor-mediated delivery.

Malecova B, Sala D, Melikian GM et al. · Nucleic acids research · (2026) · View on PubMed ↗

Developmental biology & regenerative models​

A transgene-free, human peri-gastrulation embryo model presents trilaminar embryonic disc-, amnion- and yolk sac-like structures.​

This study developed a transgene-free human peri-gastrulation embryo model (peri-gastrulation trilaminar embryonic disc, PTED) derived from primed human pluripotent stem cells. It found that PTED embryoids form trilaminar embryonic disc-like, amnion-like, and yolk sac-like structures and show primitive hematopoiesis, with lineage tracing supporting mesodermal organization between dorsal amnion and ventral definitive yolk sac. The scientific significance is that PTED provides a tractable in vitro system to study early human embryogenesis and lineage specification during peri-gastrulation.

Sun S, Zheng Y, Kim YS et al. · Nature cell biology · (2026) · View on PubMed ↗

A single-cell and spatial atlas of early human olfactory development.​

This study mapped early human olfactory development in male and female fetuses (7–12 post-conception weeks) using integrated single-nucleus RNA sequencing (snRNA-seq) and multiplexed error-robust fluorescence in situ hybridization (MERFISH) to resolve cell types and spatial gene-expression dynamics in the fetal nasal region. The atlas identified 32 distinct cell types and provided spatial-temporal markers across the olfactory epithelium and adjacent tissues. This resource improves mechanistic understanding of human olfactory lineage development and supports future studies of developmental disorders affecting smell.

Mbouamboua Y, Lebrigand K, Nampoothiri S et al. · Nature communications · (2026) · View on PubMed ↗

Molecular architecture of the ciliary base in mammalian multiciliated cells.​

This preprint studied the molecular architecture of the ciliary base in mammalian multiciliated cells from the mammalian trachea using cryo-focused ion beam (cryo-FIB) milling and cryo-electron tomography (cryo-ET), complemented by in situ cross-linking mass spectrometry (XL/MS) and ultrastructure expansion microscopy (U-ExM). The authors report in situ 3D structural and molecular insights into the transition zone and basal body/ciliary environment that had been poorly defined. Scientifically, the work provides a mechanistic framework for how ciliary base components organize to support motile cilia function and may inform future studies of ciliopathies.

McCafferty CL, Brunet M, van den Hoek H et al. · bioRxiv : the preprint server for biology · (2026) · View on PubMed ↗

Whole-organism spatial transcriptomics at single-cell resolution in C. elegans.​

This preprint developed or applied whole-organism spatial transcriptomics at single-cell resolution in Caenorhabditis elegans to map gene expression across intact worms while addressing limitations in spatial resolution and multiplexing. The key finding is that the approach enables profiling multiple gene expression patterns in the native anatomical context of whole animals at single-cell scale. The scientific significance is enabling circuit- and behavior-linked molecular mapping in a genetically tractable organism, accelerating discovery of spatially organized gene regulation.

Aguirre Aguilera JD, Wan X, Tischbirek CH et al. · bioRxiv : the preprint server for biology · (2026) · View on PubMed ↗

Clinical guidelines, comparative effectiveness & trial evidence​

Diagnostic Criteria and Management of MELAS and Stroke-Like Episodes: Consensus-Based Statements.​

This consensus article studied diagnostic criteria and management strategies for mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) and mitochondrial stroke-like episodes (SLE) across pediatric and adult populations using an international Delphi process coordinated by ERN EURO-NMD and the US Mitochondrial Medicine Society. It produced standardized, consensus-based recommendations for defining, diagnosing, and treating MELAS/SLE to reduce variability in clinical practice. The guideline is significant because it provides a unified framework for earlier recognition and more consistent management of these rare mitochondrial disorders.

Mancuso M, Bellusci M, Carelli V et al. · European journal of neurology · (2026) · View on PubMed ↗

Romosozumab Versus Teriparatide for the Treatment of Postmenopausal Osteoporosis: An Overview of Systematic Reviews With Direct and Indirect Meta-Analyses.​

This overview of systematic reviews studied the comparative efficacy and safety of romosozumab versus teriparatide for postmenopausal osteoporosis by summarizing 13 eligible systematic reviews with meta-analyses identified through searches up to November 2023. It reported that romosozumab did not show a significant difference in falls risk at 12–24 months while synthesizing broader comparative outcomes on fracture risk and safety. The overview is significant for informing treatment selection between anabolic osteoporosis therapies in postmenopausal women.

Bandeira TFGS, Aguiar PM, Vianna CMM et al. · International journal of rheumatic diseases · (2026) · View on PubMed ↗

Boron neutron capture therapy (BNCT) for experimental bladder cancer: systemic or intravesical approach.​

This experimental study evaluated boron neutron capture therapy (BNCT) for bladder cancer in Wistar rats, comparing systemic versus intravesical delivery of borophenilalanine and benchmarking against conventional radiotherapy (cRT). It used carcinogen-induced bladder cancer models and assessed tumor staging/burden as well as proliferative and apoptotic indexes after BNCT delivered at the MARK TRIGA-II reactor versus cRT. The significance is that it tests whether route of boron delivery (systemic vs intravesical) changes antitumor and pro-inflammatory outcomes relative to standard radiotherapy in bladder cancer.

Teke K, Özer C, Yaprak Bayrak B et al. · British journal of cancer · (2026) · View on PubMed ↗

UK BioCoin: swift trait-specific summary statistics regression for UK Biobank.​

This study developed UK BioCoin (UKC), a computational method for generating trait-specific summary statistics regression for UK Biobank without requiring individual-level data access. Using UK Biobank data (505 traits, ~10 million SNPs), UKC produced summary statistics that closely matched individual-level covariate-adjusted results while achieving ~80× greater computational efficiency. The method enables more flexible, user-specified covariate adjustments for genetic association analyses using only summary statistics.

He J, Qi G, Ying J et al. · Nature communications · (2026) · View on PubMed ↗

Efgartigimod in Sjögren's disease: a phase 2, randomised, placebo-controlled, parallel-group, double-blinded, proof-of-concept study (RHO).​

In adults with Sjögren’s disease, this phase 2 multicentre randomized, double-blind, placebo-controlled proof-of-concept study (RHO) evaluated intravenous efgartigimod 10 mg/kg once weekly for 24 weeks versus placebo, with efficacy assessed using the CRESS responder composite at week 24. Efgartigimod increased the proportion of CRESS responders and improved multiple secondary domains of systemic disease activity, patient-reported symptoms, tear/salivary gland function, and serology compared with placebo. These findings provide early clinical proof-of-concept for FcRn inhibition as a therapeutic strategy in Sjögren’s disease.

Peene I, Verstappen GM, Arends S et al. · Annals of the rheumatic diseases · (2026) · View on PubMed ↗

Thiamine deficiency in cancer patients at initial admission to a palliative care unit: a single-centre cross-sectional study.​

This single-centre cross-sectional study of end-of-life cancer patients at initial admission to a palliative care unit measured whole-blood thiamine concentrations using high-performance liquid chromatography to determine the prevalence of thiamine deficiency and associated factors. Thiamine deficiency was common on admission, and the study identified clinical factors linked to lower thiamine status. The results highlight the need for routine screening and potential thiamine repletion strategies in palliative oncology populations.

Sato R, Ishida M, Uchida N et al. · BMJ supportive & palliative care · (2026) · View on PubMed ↗

Gastrointestinal Disorders in Scleroderma.​

This review synthesized evidence on gastrointestinal disorders across the spectrum of scleroderma/systemic sclerosis, emphasizing how vasculopathy, immune-mediated inflammation, and neuropathy drive GI involvement from esophagus to bowel. It summarizes the high prevalence of esophageal disease (including dysphagia and GERD) and other segment-specific complications such as gastroparesis and gastric antral vascular ectasia (GAVE). Clinically, the article provides an integrated framework to guide recognition, risk stratification, and management of GI manifestations in systemic sclerosis.

Quigley EMM, McMahan ZH, Kulkarni S et al. · Gastroenterology · (2026) · View on PubMed ↗

Lumen-apposing metal stents vs. self-expandable metal stents for endoscopic ultrasound-guided choledocoduodenostomy: a network meta-analysis of randomized controlled trials.​

Using a network meta-analysis of randomized controlled trials, investigators compared lumen-apposing metal stents (LAMS)—specifically cautery-enhanced LAMS (CE-LAMS)—versus self-expandable metal stents (SEMS) for endoscopic ultrasound-guided choledocoduodenostomy (EUS-CDS), with ERCP as a common comparator in malignant distal biliary obstruction. The analysis evaluated relative outcomes for stent patency and safety between CE-LAMS-based and conventional SEMS-based strategies. These comparative effectiveness results help clinicians choose the optimal EUS-CDS stent strategy to balance patency and adverse events in malignant distal biliary obstruction.

Spadaccini M, Chen YI, van Wanrooij RLJ et al. · Endoscopy · (2026) · View on PubMed ↗

Accelerating discovery of cancer causes for prevention in the era of rising early-onset cancers.​

This perspective addressed the rising incidence of early-onset cancers and the need to accelerate discovery of causes for prevention by integrating epidemiologic and mechanistic research. It argues that birth-cohort effects and global epidemiologic shifts require new frameworks that connect tissue-level biology with cause discovery and translation into prevention/interception strategies. The significance is that improved cause-discovery pipelines could enable earlier interventions and reduce the burden of cancers in younger populations.

Shi M, Patti GJ, Gunter MJ et al. · Cell · (2026) · View on PubMed ↗

Orthokeratology for stable mild-to-moderate keratoconus: a pilot study on safety and corneal remodeling via quantitative OCT analysis.​

This pilot prospective cohort study evaluated overnight orthokeratology (Ortho-K) using Euclid Emerald lenses in 14–21-year-old patients with stable mild-to-moderate keratoconus (Amsler–Krumeich grades I–II), assessing corneal remodeling with quantitative optical coherence tomography (OCT) over 18 months. The key finding is that Ortho-K was assessed for safety and for measurable epithelial and Bowman's layer structural changes alongside visual and refractive outcomes (UCVA/BCVA, refraction, axial length, and corneal topography). Scientifically, it provides early evidence that quantitative OCT can track corneal remodeling effects of Ortho-K in keratoconus.

Zhang C, Hu Z, Li W et al. · International ophthalmology · (2026) · View on PubMed ↗

Infusion-Related Reactions from Immune Checkpoint Inhibitors in Solid Tumors: A Proportional and Network Meta-Analysis.​

This proportional and network meta-analysis studied infusion-related reactions (IRRs) across immune checkpoint inhibitor (ICI) therapies in solid tumors by pooling phase 3 randomized controlled trials comparing CTLA-4, PD-1, PD-L1, and LAG-3 inhibitors (including dual ICI regimens) versus placebo/observation. The key finding is that IRR incidence varies by ICI type and regimen, and the analysis estimates odds ratios using random-effects network meta-analysis and additional proportional meta-analysis (as described in the abstract). Clinically, it provides comparative risk estimates to inform selection and monitoring strategies for IRRs during ICI treatment.

Fujiwara Y, Takahashi T, Tsuchiya K et al. · Targeted oncology · (2026) · View on PubMed ↗

A model-based prion vaccine protects a transgenic mouse line carrying a Gerstmann-Sträussler-Scheinker disease mutation.​

The study developed and tested a model-based prion vaccine designed to mimic predicted surface immunogenic features of the infectious prion conformer (PrPSc) in a transgenic mouse line carrying a Gerstmann-Sträussler-Scheinker (GSS) disease mutation. The vaccine protected the transgenic mice against prion disease, outperforming prior immunization strategies that primarily targeted the normal cellular prion protein (PrPC). This supports a structure-informed vaccination strategy for prion diseases where direct targeting of heterogeneous PrPSc has been difficult.

Fang A, Tang X, Fleming M et al. · Acta neuropathologica · (2026) · View on PubMed ↗

Romosozumab versus teriparatide for risk of dementia in individuals with osteoporosis: a target trial emulation study.​

This target-trial emulation study analyzed longitudinal Japanese claims data from 69,543 individuals with osteoporosis to compare romosozumab initiation versus teriparatide initiation for incident dementia risk. Romosozumab initiation was associated with a lower risk of dementia compared with teriparatide initiation. If confirmed prospectively, these findings could inform bone–brain risk management when selecting osteoporosis therapies.

Hatano M, Okada A, Sasabuchi Y et al. · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · (2026) · View on PubMed ↗

The ecological dynamics of skin microbiota in skin health and diseases.​

This 2026 review synthesized evidence on how skin microbiota composition and function relate to skin health and diseases, focusing on host–microbe interactions relevant to conditions such as atopic dermatitis, psoriasis, and acne. It highlights that dysbiosis and specific taxa (e.g., Staphylococcus aureus and Cutibacterium acnes) can either promote or protect against disease through immune and barrier-related mechanisms. The review frames skin microbiome profiling as a potential avenue for improved diagnostics and microbiome-targeted therapies.

Pu P, Wang Y, Liu X et al. · Clinical microbiology reviews · (2026) · View on PubMed ↗

Exposure to air pollution and risk of gastrointestinal diseases: a systematic review and meta-analysis of epidemiological evidence.​

This systematic review and meta-analysis evaluated epidemiologic studies linking air pollution exposure to gastrointestinal diseases, including both long- and short-term exposures to PM2.5, PM10, and gaseous pollutants (NO2, SO2, CO, O3). Across 70 included studies, the authors synthesized pollutant-specific associations with GI outcomes using random-effects models per pollutant increment. The findings support an evidence-based link between air pollution and GI disease risk, informing public health and risk-reduction priorities.

Hao M, Zhang J, Yang Z et al. · Epidemiologic reviews · (2026) · View on PubMed ↗

Transcatheter Intra-Arterial Delivery of a Platelet-Derived Extracellular Vesicle-Enriched Preparation for Attenuating Skeletal Muscle Ischaemia-Reperfusion Injury in a Rodent Forelimb Model.​

This rodent forelimb ischemia–reperfusion injury (IRI) study tested transcatheter intra-arterial delivery of a platelet-derived extracellular vesicle (EV)-enriched preparation to attenuate skeletal muscle IRI. The approach was designed to exploit platelet EV anti-inflammatory and antioxidant properties to reduce sterile reperfusion injury. These preclinical data support EV-based vascular delivery as a potential therapeutic strategy for limb reperfusion syndromes.

Selim OA, Sarcon A, Behfar A et al. · Journal of extracellular vesicles · (2026) · View on PubMed ↗

Safety and Efficacy of Direct Oral Anticoagulants Versus Vitamin K Antagonists for Cerebrovascular Ischemic Outcomes in Non-Valvular Atrial Fibrillation: A Systematic Review and Meta-Analysis.​

This systematic review and meta-analysis compared direct oral anticoagulants (DOACs) versus vitamin K antagonists (VKAs) for cerebrovascular ischemic outcomes in non-valvular atrial fibrillation. Using PRISMA 2020-guided searches of PubMed, ClinicalTrials.gov, and the Cochrane Library, it synthesized randomized trial evidence on ischemic stroke/TIA and related safety outcomes. The results aim to inform anticoagulant selection for stroke prevention in non-valvular AF.

Nasir A, Anwar N, Kamran AB et al. · Clinical cardiology · (2026) · View on PubMed ↗

Oropharyngeal cancer mortality in the United States, 1999-2023: a surveillance analysis using CDC WONDER.​

This surveillance analysis used CDC WONDER data to examine oropharyngeal cancer (OPC) mortality trends and demographic/geographic disparities in the United States from 1999 to 2023. The key finding was that age-adjusted OPC mortality rates increased over time (from 1999 to 2023) with patterns suggesting evolving disparities across the period. Public-health significance lies in identifying changing mortality burden and subgroup differences to guide prevention, screening, and resource allocation.

Deng W, Cao L, Li Z · Frontiers in oncology · (2026) · View on PubMed ↗

Comparative effectiveness of non-pharmacological traditional Chinese medicine therapies for chronic fatigue syndrome: a systematic review and network meta-analysis.​

This systematic review and network meta-analysis compared non-pharmacological Traditional Chinese Medicine (TCM) therapies for chronic fatigue syndrome (CFS) using a broad database search completed January 1, 2026. The key finding was an evidence-based ranking of comparative effectiveness across different non-pharmacological TCM interventions, with study quality and confidence assessed using risk-of-bias tools and CINeMA. Clinically, it helps clinicians and researchers identify which TCM modalities may offer the best symptom benefit for CFS while highlighting gaps for future trials.

Zhang Y, Zhou Y, Xu H et al. · Frontiers in medicine · (2026) · View on PubMed ↗

Experts' recommendations for the management of adult patients with cardiogenic shock.​

This work studied expert consensus recommendations for managing adult cardiogenic shock (CS), using the GRADE framework developed by French Intensive Care Society (SRLF) and French Society of Cardiology (SFC) with input from SFAR and the French Society of Thoracic Surgery. The key finding is a structured, updated guideline set addressing CS management across etiologies in adults, reflecting evidence appraisal and recommendation grading. Clinically, it aims to standardize care and improve outcomes in a high-mortality condition where prior European recommendations were more than a decade old.

Aissaoui N, Delmas C, Merdji H et al. · Annals of intensive care · (2026) · View on PubMed ↗

Clinical and endocrine effects of pharmacological therapy in endometriosis: a systematic review and meta-analysis.​

This systematic review and meta-analysis evaluated clinical and endocrine effects of pharmacological therapies for endometriosis in women, including combined oral contraceptives (COCs), progestins, GnRH analogues, levonorgestrel-releasing intrauterine system (LNG-IUS), and relugolix, across 149 clinical trials. The key finding is that these hormonal and non-hormonal treatments show benefits of varying magnitude on clinical/endocrine outcomes, with evidence quality assessed using Jadad and GRADE and effect sizes extracted when available. Scientifically and clinically, it consolidates comparative evidence to guide selection of endometriosis therapies based on the strength of outcomes and reliability of the data.

Sun R, Xu H, Ma R et al. · Frontiers in endocrinology · (2026) · View on PubMed ↗

Redefining standards: a comprehensive systematic review of practice changing advances in GU oncology from ASCO and ESMO 2025.​

This comprehensive systematic review studied practice-changing advances in genitourinary (GU) oncology from ASCO and ESMO 2025, synthesizing pivotal phase II/III randomized controlled trials across bladder, kidney, prostate, penile, and testicular cancers. The key finding is that 2025 trial results are reshaping therapeutic standards through novel mechanisms and more refined personalization strategies. Clinically, it provides an evidence-focused map of how 2025 data should influence current GU cancer treatment paradigms.

Ismaili N · Frontiers in endocrinology · (2026) · View on PubMed ↗

Translational Models for Glioblastoma: Revolutionizing Drug Development and Personalized Medicine through Clinical Insights.​

This article reviewed translational experimental models for glioblastoma (GBM) drug development, focusing on how current preclinical platforms (cell lines, 2D cultures, and animal models) fail to capture GBM tumor microenvironment, blood–brain barrier function, and interpatient heterogeneity. It highlights that late-stage clinical trial failures reflect limited predictive value of conventional models and argues for advanced translational systems to better mirror these determinants of therapeutic resistance. The significance is improved model-to-clinic translation for personalized GBM therapies and more reliable selection of candidate drugs before late-stage testing.

Lee G, Kim YJ, Ham SJ et al. · Theranostics · (2026) · View on PubMed ↗

Exploring medication adherence and illness perception in patients with neuroimmune diseases: a cross-sectional study.​

This cross-sectional study examined medication adherence and illness perception in patients with neuroimmune diseases—myasthenia gravis (MG), multiple sclerosis (MS), and neuromyelitis optica spectrum disorder (NMOSD)—enrolling individuals from the outpatient neurology clinic at West China Hospital, Sichuan University (March–August 2025) with ≥6 months of treatment. The key finding is the identification of factors associated with adherence and the relationship between adherence and illness perception using the Eight-Item Morisky Medication Adherence Scale (MMAS-8). Clinically, the results aim to inform interventions to improve long-term adherence and prognosis in chronic neuroimmune conditions.

Fu R, Wang X, Shi Z et al. · Frontiers in immunology · (2026) · View on PubMed ↗

Generated automatically on April 23, 2026 from PubMed's trending articles. Summaries are AI-generated; always consult the original publication for clinical or research decisions.

Automated digest · 99 articles · 15 research areas · March 22, 2026

Overview​

Across this week’s set, a dominant thread is the move from mechanistic insight to scalable clinical impact—especially via biomarkers, decision support, and real-world evidence. AI-enabled tools (e.g., stroke CDSS and AI-assisted patient education) and imaging/biomarker strategies (retinal risk atlases, PET metabolic tumor volume in CAR T, ctDNA for de-escalation decisions, and liquid biopsy approaches for EBV+ Burkitt’s lymphoma) reflect a broader push toward earlier risk stratification and more personalized care. Several studies also emphasize translating biological heterogeneity into clinical decision-making, such as immune-dysregulation–guided immunomodulation in pneumonia/sepsis and immune- or hypoxia-informed prognostic models after cancer therapies.

Mechanistically, immune regulation and immunometabolism recur throughout oncology and inflammatory disease. Multiple papers connect specific immune pathways (TAM-driven signaling axes, macrophage/immune escape programs, necroptosis/necroinflammation, immunothrombosis in NEC, and tumor microenvironment remodeling via targets like WIP1/PPM1D) to therapy resistance or treatment response—often suggesting combination strategies (e.g., checkpoint sensitization, TAM pathway inhibition, or pairing metabolic/immune vulnerabilities). In parallel, metabolism-linked mechanisms—lactylation and mitochondrial quality control in cancer and degenerative disease, microbiome-derived metabolites (serotonin, indole/indoxyl sulfate, microbial lipids) shaping organ outcomes, and nutrient-stress death pathways like mitoxyperilysis and ferroptosis—highlight how upstream metabolic and cellular stress programs can be drugged.

Finally, the digest spans major clinical domains beyond cancer: cardiovascular and cardiopulmonary risk stratification (PVR in group 2 PH, fibrinogen–Bmal1 in aortic dissection, RhoA inhibition in heart failure), neuroimmune framing of syndromes (POTS/ME-CFS/Long COVID), and neurodegeneration links (OSA–astrocyte dysfunction, oxidative stress/inflammasome pathways in Alzheimer’s, and circadian control of pain). Together, these studies reinforce a unifying theme: complex diseases are increasingly being understood as networked systems—where timing, immune state, metabolism, and measurable biomarkers jointly determine outcomes.

AI-enabled clinical decision support & digital health​

Effect of a clinical decision support system on stroke care quality and outcomes in patients with acute ischaemic stroke (GOLDEN BRIDGE II): cluster randomised clinical trial.​

This multicentre cluster randomised clinical trial evaluated a stroke clinical decision support system (CDSS) using artificial intelligence-assisted imaging analysis, stroke-cause classification, and evidence-based treatment recommendations in 77 Chinese hospitals treating 21,603 adults with acute ischaemic stroke within 7 days of symptom onset. Hospitals receiving the CDSS support improved stroke care quality and clinical outcomes compared with control hospitals. These findings suggest that AI-enabled CDSS integrated into routine hospital workflows can enhance real-world stroke management and patient prognosis at scale.

Zhang X, Ding L, Jing J et al. · BMJ (Clinical research ed.) · (2026) · View on PubMed ↗

Effectiveness of Al-Assisted Patient Health Education Using Voice Cloning and ChatGPT: Prospective Randomized Controlled Trial.​

This prospective randomized controlled trial evaluated AI-assisted patient health education that combined voice cloning and ChatGPT, comparing different voice-cloning strategies and assessing the reliability of automated AI evaluation tools. The study tested whether the AI-delivered, personalized and interactive education improved patient outcomes compared with conventional approaches (details truncated in the provided abstract). If effective, this would support scalable, personalized digital health education workflows using voice cloning plus large language models.

Sun Y, Xu S, Jin H et al. · Journal of medical Internet research · (2026) · View on PubMed ↗

Targeted protein degradation & drug discovery platforms​

Hijacking ERAD for targeted degradation of transmembrane proteins.​

This study developed ERAD-engaging chimeras (ERADECs), a targeted protein degradation (TPD) platform that hijacks ER-associated degradation (ERAD) to degrade transmembrane proteins, and tested it by designing ERADECs targeting programmed death-ligand 1 (PD-L1). The authors identified desonide as a binder of the ER E3 ligase SYVN1 and showed that ERADECs efficiently degraded PD-L1 with high efficacy. The work provides a mechanistic and design framework for degrading difficult ER-folded transmembrane targets, potentially expanding TPD drug-discovery beyond soluble proteins.

Song H, Wang W, Mei T et al. · Cell · (2026) · View on PubMed ↗

Human DHX29 detects nonoptimal codon usage to regulate mRNA stability.​

This study examined how the human RNA helicase DHX29 regulates mRNA stability in response to nonoptimal codon usage in human cells. Using genome-wide CRISPR screening plus cryogenic electron microscopy and selective ribosome profiling, it found that DHX29 directly interacts with the A-site entrance of the translating 80S ribosome (the eEF1A•GTP•aminoacyl-tRNA ternary complex binding region), supporting a role in monitoring aminoacyl-tRNA sampling and codon-dependent gene expression. These findings reveal a specific molecular mechanism by which codon quality is sensed to control mRNA fate in humans.

Hia F, Wu Y, Yoshinaga M et al. · Science (New York, N.Y.) · (2026) · View on PubMed ↗

Unstructured transcription factor interactions enable emergent specificity.​

This study investigated how intrinsically disordered regions (IDRs) enable emergent specificity in transcription factor interactions with chromatin and each other in live cells. Using proximity-assisted photoactivation (PAPA), it found that the Sp1 DNA-binding domain alone interacts poorly with chromatin, but that fusing an IDR to Sp1 can confer sharp locus specificity, with live imaging in Drosophila polytene chromosomes supporting IDR-driven targeting. This demonstrates how unstructured protein segments can generate functional specificity beyond canonical DNA-binding alone.

Abidi AA, Cattoglio C, Tang NN et al. · Science (New York, N.Y.) · (2026) · View on PubMed ↗

Stage-specific transcriptomics of a leader cell reveals cell machineries driving collective invasion.​

This study generated stage-specific transcriptomic profiles of the Caenorhabditis elegans gonadal leader cell, the distal tip cell (DTC), comparing invasive larval-stage DTCs with noninvasive adult-stage DTCs. The invasive-stage transcriptome revealed molecular programs and cell-machinery signatures that drive collective invasion in vivo. The dataset and identified regulators provide a mechanistic framework for how leader cells coordinate invasion relevant to development, tissue repair, and metastasis.

Agarwal P, Maimon Zielonka I, Gingold H et al. · The Journal of cell biology · (2026) · View on PubMed ↗

Regulation of YAP activity by nuclear G-actin binding.​

This mechanistic study investigated how nuclear G-actin binding regulates the activity of YAP, a TEAD-associated transcriptional co-activator in the Hippo pathway. The key finding is that binding of monomeric actin (G-actin) in the nucleus modulates YAP activity, linking actin cytoskeletal dynamics to transcriptional control of proliferation, differentiation, and mechanotransduction. This advances understanding of how cytoskeletal/biomechanical signals are converted into YAP-driven gene expression programs relevant to development and cancer metastasis.

Wang H, Jayawardana IM, Fleisch JM et al. · Nucleic acids research · (2026) · View on PubMed ↗

Inflammation, immunomodulation & immune microenvironment​

USP25 regulates atherosclerosis by restricting RIPK1-mediated inflammatory responses.​

This mechanistic study investigated how the deubiquitinase USP25 regulates atherosclerosis by restricting RIPK1-mediated inflammatory responses, using analyses of human atherosclerotic lesions and ApoE-/- mouse models. USP25 was downregulated in human lesions, and restoring/defining USP25 function reduced atherosclerosis by limiting RIPK1-driven inflammatory signaling, with USP25 substrates identified by mass spectrometry. These results position USP25 as a potential therapeutic target to dampen inflammation-driven progression of atherosclerosis.

Su X, Zhou B, Xu Y et al. · EBioMedicine · (2026) · View on PubMed ↗

CD177⁺ neutrophil-platelet aggregates contribute to thromboinflammation via NETs in necrotizing enterocolitis.​

The study investigated necrotizing enterocolitis (NEC) pathogenesis by focusing on CD177+ neutrophil–platelet aggregates and their contribution to thromboinflammation via neutrophil extracellular traps (NETs) in clinical NEC samples and neonatal mouse models. It found that NEC is characterized by immunothrombosis with infiltrating CD177+ neutrophils and activated platelets, linked to NET-mediated thromboinflammatory injury. This mechanistic evidence highlights CD177+ neutrophil–platelet interactions and NETs as potential targets to prevent or treat NEC in premature infants.

Lan C, Tian B, Shi Y et al. · Nature communications · (2026) · View on PubMed ↗

Quantifying immune dysregulation in pneumonia and sepsis with a parsimonious machine-learning model: a multicohort analysis across care settings and reanalysis of a hydrocortisone randomised controlled trial.​

This multicohort machine-learning analysis quantified immune dysregulation in pneumonia and sepsis and reanalyzed data from a hydrocortisone randomized controlled trial to assess biologically informed immunomodulation. The key finding is that a parsimonious immune-dysregulation model can stratify patients by the extent of dysregulation rather than only clinical severity, potentially explaining heterogeneity in treatment response. Scientifically and clinically, it supports more targeted use of immunomodulators like hydrocortisone by identifying patients most likely to benefit.

Michels EHA, Dequin PF, Butler JM et al. · The Lancet. Respiratory medicine · (2026) · View on PubMed ↗

Psoriasis modulates inflammatory bowel disease risk and intestinal epithelium lipid metabolism via IL-1β-producing macrophages.​

This work studied how psoriasis influences inflammatory bowel disease risk and intestinal epithelial lipid metabolism, focusing on IL-1β-producing macrophages, using a clinical cohort, experimental psoriasis mouse models, and intestinal organoids. Psoriasis severity inversely correlated with postprandial apolipoprotein B48 levels, and a recombinant photoconvertible apolipoprotein B reporter enabled real-time quantification of chylomicron production showing psoriasis-driven impairment of intestinal lipid handling. These results mechanistically link psoriasis-associated IL-1β macrophage activity to dysregulated lipid metabolism that may contribute to increased IBD risk.

Wu J, Liu S, Dan W et al. · Cell metabolism · (2026) · View on PubMed ↗

Gsα deficiency in macrophages promotes tumor progression via the MAPK signaling pathway.​

This preclinical study investigated whether Gsα (G protein alpha subunit) deficiency in tumor-associated macrophages (TAMs) affects tumor progression through MAPK signaling using mouse models with B16 and MC38 tumor cells. It reports that Gsα-deficient TAMs accelerate tumor growth and metastasis and that the effect is mediated via activation of the MAPK pathway. These results are clinically relevant because they suggest that restoring or targeting Gsα–MAPK signaling in TAMs could be a strategy to reprogram immunosuppressive macrophages and slow cancer progression.

Yan W, Yang J, Tan S et al. · Journal of molecular medicine (Berlin, Germany) · (2026) · View on PubMed ↗

Albumin-Bound STING Agonist Reprograms HSPCs to Antitumor Neutrophils Enhancing CD8+ T Cell Immunity.​

In preclinical cancer immunology experiments, an albumin-bound STING agonist (Nano ZSA-51D) was tested for its ability to reprogram hematopoietic stem and progenitor cells (HSPCs) into antitumor neutrophils. Nano ZSA-51D enhanced MHC I–mediated CD8+ T cell immunity and sensitized tumors to α-PD1 immunotherapy by shifting neutrophil fate toward antitumor phenotypes. This provides a strategy to improve checkpoint blockade efficacy by targeting innate immune programming at the HSPC stage.

Tao J, Zhao HY, Li C et al. · Advanced science (Weinheim, Baden-Wurttemberg, Germany) · (2026) · View on PubMed ↗

ECM1 produced by hepatic stellate cells serves as gate keeper of liver homeostasis in hepatic fibrosis.​

This study examined hepatic stellate cell (HSC) homeostatic functions during fibrogenesis in Lrat-iDTR inducible HSC ablation mice, comparing two injury contexts: CCl4-driven parenchymal injury and metabolic dysfunction–associated steatohepatitis (MASH) induced by a choline-deficient high-fat diet (CD-HFD). The authors report that ECM1 produced by hepatic stellate cells acts as a “gate keeper” of liver homeostasis and that preserving this HSC homeostatic program is important for limiting maladaptive fibrosis while maintaining regeneration. These findings identify ECM1/HSC homeostasis as a potential therapeutic target to treat liver fibrosis without fully disabling beneficial HSC functions.

Yang A, Yan X, Wang Y et al. · Hepatology (Baltimore, Md.) · (2026) · View on PubMed ↗

A Rare RIPK3 Variant Enhances Necroptosis and Promotes Inflammation in a Still's Disease-like Autoinflammatory Syndrome.​

This study investigated a novel autoinflammatory syndrome resembling Still’s disease in a three-generation family using whole-exome sequencing to identify a RIPK3 p.Q134K variant and then performed functional assays to test its effects on kinase activity, necroptosis, and inflammatory signaling. The key finding is that the RIPK3 p.Q134K variant enhances necroptosis and promotes inflammatory signaling compared with expected wild-type behavior. This provides a mechanistic genetic explanation for a Still’s disease–like phenotype and highlights RIPK3-driven necroptosis as a potential therapeutic pathway in related autoinflammatory conditions.

Chen L, Dai Q, Xiao Y et al. · Arthritis & rheumatology (Hoboken, N.J.) · (2026) · View on PubMed ↗

Cancer immunotherapy, immune evasion & checkpoint sensitization​

Targeting tumor-associated macrophages-induced IGF1/PI3K/Zic1 axis triggers SHH medulloblastoma regression and chemosensitization.​

The study tested whether targeting the tumor-associated macrophage (TAM)-induced IGF1/PI3K/Zic1 axis can trigger SHH medulloblastoma regression and chemosensitization. In a CD11b-DTR/Ptch1-deficient medulloblastoma mouse model, TAM genetic deletion and pharmacologic inhibition using the CSF1R inhibitor PLX3397 and the PI3K inhibitor buparlisib (alone or with chemotherapy) produced tumor regression and increased chemosensitivity, supported by RNA-seq, Western blotting, flow cytometry, immunohistochemistry, and qPCR analyses. This is significant because it links a specific TAM-driven signaling axis (IGF1/PI3K/Zic1) to SHH pathway control and suggests combination strategies to overcome medulloblastoma chemoresistance.

Pang YC, Wang C, Qiu JF et al. · Neuro-oncology · (2026) · View on PubMed ↗

Targeting WIP1 reprograms immunosuppressive tumor microenvironment to potentiate immunotherapy response in colorectal cancer.​

The study investigated wild-type p53-induced phosphatase 1 (WIP1/PPM1D) as an immunosuppressive driver in colorectal cancer and tested genetic or pharmacological WIP1 inhibition in tumor models. It found that inhibiting WIP1 suppressed tumor growth by remodeling the tumor microenvironment, increasing infiltration of anti-tumor macrophages and cytotoxic T cells and dampening type I interferon (IFN) signaling. This positions WIP1/PPM1D as a therapeutic target to potentiate immune checkpoint inhibitor responses by reversing innate immune suppression in CRC.

Chen L, Chen M, Yuan S et al. · Cell death and differentiation · (2026) · View on PubMed ↗

CAV1-DOT1L axis in TAM-derived EVs orchestrates VM and sensitises PDAC to combined VM and VEGF targeting.​

This mechanistic study investigated how the CAV1–DOT1L axis in tumor-associated macrophage (TAM)-derived extracellular vesicles (EVs) regulates vasculogenic mimicry (VM) and sensitizes pancreatic ductal adenocarcinoma (PDAC) to combined VM and VEGF targeting. The key finding is that TAM-derived EVs carrying signals through the CAV1–DOT1L axis orchestrate VM and increase therapeutic sensitivity to strategies targeting VM together with VEGF. This is significant because it identifies a specific immune–epigenetic EV pathway and a potential combination vulnerability for treating aggressive PDAC.

Liu Z, Zhang Y, Wu H et al. · Gut · (2026) · View on PubMed ↗

Unveiling the multifaceted roles of BCL3: biological functions and disease implications.​

This review article examined the atypical NF-κB inhibitor-of-κB family member BCL3 and its regulation by post-translational modifications, focusing on how BCL3 functions in normal biology and disease. It reports that nuclear BCL3 acts as a bidirectional transcriptional regulator within NF-κB signaling, and that in pathological contexts BCL3 promotes oncogenic phenotypes including abnormal proliferation, apoptosis inhibition, metastasis, and chemotherapy resistance in hematologic malignancies. These mechanistic insights position BCL3 as a potential therapeutic target for NF-κB–driven cancers, where modulating its phosphorylation-dependent activity could alter tumor progression and treatment response.

Guo X, Guo R, Wang W et al. · Apoptosis : an international journal on programmed cell death · (2026) · View on PubMed ↗

HTRA1+ macrophages induce T cells egress through CRIP1/NF-κB/CXCL12 to limit the effects of immunotherapy in triple-negative breast cancer.​

In triple-negative breast cancer (TNBC), this study used single-cell and spatial transcriptomics to define a macrophage subpopulation characterized by high HTRA1 expression that drives T cell egress during immunotherapy. HTRA1+ macrophages induced T cell egress via a CRIP1/NF-κB/CXCL12 signaling axis, which limited the effectiveness of immunotherapy. Mechanistically, this identifies a macrophage-driven immune escape pathway that could be targeted to improve responses to immunotherapy in TNBC.

Weng J, Xu W, Wang F et al. · Cancer immunology research · (2026) · View on PubMed ↗

Cancer therapeutics & drug development (ADC/bioconjugates/targeted agents)​

SHR-A1811, a novel HER2-targeting antibody-drug conjugate, in advanced solid tumors (HORIZON-X): a global phase 1 trial.​

The study reported long-term follow-up from the global phase 1 HORIZON-X trial evaluating SHR-A1811, a HER2-targeting antibody-drug conjugate, in adults with advanced solid tumors. It found that SHR-A1811 (trastuzumab linked via a cleavable linker to a topoisomerase I inhibitor payload) showed substantial antitumor activity in heavily treated patients with HER2-expressing or HER2-mutated tumors, with dosing by intravenous administration across multiple cohorts. This is clinically significant because it extends early-phase evidence for a next-generation HER2 ADC with potential activity in refractory HER2-driven cancers.

Yao H, Yan M, Tong Z et al. · Signal transduction and targeted therapy · (2026) · View on PubMed ↗

A bispecific nanobody-drug conjugate targeting TROP2 and c-Met for low-concentration, single-dose treatment of pancreatic cancer.​

This preclinical study developed B6ADC, a nanobody-based bispecific antibody-drug conjugate targeting TROP2 and c-Met, and tested it in TROP2/c-Met-expressing pancreatic cancer cell lines and mouse tumor models. B6ADC showed potent in vitro cytotoxicity across multiple TROP2/c-Met-positive lines and superior in vivo tumor inhibition versus single-target ADCs and their combinations, including sacituzumab govitecan (TROP2 ADC) and Teliso-V (c-Met ADC). These findings suggest that dual TROP2/c-Met targeting with a nanobody-drug conjugate could improve efficacy despite antigen heterogeneity and limited tumor penetration in pancreatic cancer.

Ning W, Liu H, Zeng H et al. · Cell reports. Medicine · (2026) · View on PubMed ↗

Long-term outcomes of eribulin‑based neoadjuvant chemotherapy for triple‑negative breast cancer patients stratified by homologous recombination deficiency status: results of the randomized JBCRG-22 study.​

This randomized JBCRG-22 study investigated long-term outcomes of eribulin-based neoadjuvant chemotherapy in triple-negative breast cancer (TNBC) patients stratified by homologous recombination deficiency (HRD) and germline BRCA mutation (gBRCAm) status. The trial compared paclitaxel+carboplatin vs eribulin+carboplatin (both followed by anthracycline) in HRD-positive/gBRCAm-eligible group A, and eribulin combinations (eribulin+cyclophosphamide vs eribulin+capecitabine) in group B, with outcomes reported by HRD/gBRCA stratification. These results are scientifically and clinically important because they test whether HRD/gBRCA status can inform selection of eribulin-containing neoadjuvant regimens to improve durable outcomes in TNBC.

Masuda N, Yasojima H, Bando H et al. · Breast cancer research and treatment · (2026) · View on PubMed ↗

Cancer biomarkers & liquid biopsy / imaging prognostication​

Liquid biopsy for the diagnosis of EBV-positive Burkitt's lymphoma in endemic areas.​

The study evaluated a blood-based liquid biopsy approach for diagnosing Epstein–Barr virus (EBV)-positive Burkitt’s lymphoma (BL) in endemic settings. In 377 children and young adults with suspected lymphoma in Tanzania and Uganda, the authors used circulating tumor DNA markers—including MYC mutations, MYC–immunoglobulin translocations, and EBV fragmentomics—alongside pathology capacity building to establish diagnostic accuracy and turnaround time against a gold-standard tissue diagnosis. The significance is that it provides a scalable diagnostic pathway where pathology resources are limited, potentially reducing delays in BL diagnosis.

Chamba C, Christopher H, Josephat E et al. · Nature medicine · (2026) · View on PubMed ↗

Extrachromosomal DNA in urothelial carcinoma: mechanisms and clinical applications.​

The study reviewed how extrachromosomal DNA (ecDNA) drives genomic instability and tumor evolution in urothelial carcinoma and how ecDNA can be detected using sequencing/imaging and liquid biopsy approaches in patients. It found that ecDNA amplifies oncogenes, alters 3D chromatin interactions, reprograms transcription, and promotes APOBEC3-associated mutational evolution, contributing to intratumour heterogeneity and aggressive disease. These insights support ecDNA as a mechanistic driver and as a clinically actionable biomarker detectable in urine/plasma for non-invasive patient stratification.

Li C, Hu Z, Zhang W et al. · Nature reviews. Urology · (2026) · View on PubMed ↗

Prognostic Significance of MSI and EBV Positivity in PD-L1 Positive Gastric Cancer: A Systematic Review and Meta-Analysis.​

The study performed a systematic review and meta-analysis to assess the prognostic significance of microsatellite instability (MSI), Epstein–Barr virus (EBV) positivity, and PD-L1 expression in PD-L1–positive gastric cancer. It synthesized studies (2010–2024) that measured MSI, PD-L1 (immunohistochemistry), and EBV (PCR or in situ hybridization) and evaluated outcomes such as overall survival and progression-free/disease-free survival. The findings are intended to refine prognostic biomarker stratification for gastric cancer patients, particularly to inform immunotherapy-related decision-making.

Petrelli F, Antista M, Ghidini A et al. · Cancer medicine · (2026) · View on PubMed ↗

A predictive atlas of disease onset from retinal fundus photographs: a modelling study using data from population-based cohorts.​

This modelling study used retinal fundus photographs from population-based cohorts to predict incident disease onset across a broad range of conditions in humans. The authors developed a predictive atlas that benchmarks how much retinal imaging adds to baseline risk for future disease. If validated, retinal fundus–based risk stratification could enable scalable, non-invasive early detection to help health systems manage rising disease burden.

Buergel T, Loock L, Steinfeldt J et al. · The Lancet. Digital health · (2026) · View on PubMed ↗

Risk Assessment in Large B-Cell Lymphoma Using Metabolic Tumor Volume: Real-World Data from a Multicenter Cohort of Patients Undergoing CAR T-Cell Therapy.​

This multicenter real-world cohort study evaluated whether PET-derived metabolic tumor volume (MTV) or MTV-based risk scores improve outcome prediction versus the International Prognostic Index (IPI) in 111 patients with relapsed/refractory large B-cell lymphoma undergoing CAR T-cell therapy. The key finding was that quantifying 18F-FDG–avid lymphoma burden/MTV provided more accurate risk assessment for nonresponse and outcomes than IPI alone. Clinically, MTV-based stratification could help identify likely nonresponders before CAR T infusion and support earlier treatment optimization.

Voltin CA, Flossdorf S, Kurch L et al. · Journal of nuclear medicine : official publication, Society of Nuclear Medicine · (2026) · View on PubMed ↗

Hypoxia-related and immune phenotype-related fusion model for non-invasive prognostication of hepatocellular carcinoma treated by TACE: a multicentre study.​

This multicentre study enrolled 1448 hepatocellular carcinoma (HCC) patients receiving transarterial chemoembolisation (TACE) to develop and validate a multimodal fusion prognostic model integrating hypoxia-related and immune phenotype-related features. The key finding is that the model improved survival prognostication and addressed limitations of existing imaging/prognostic scores by adding biological interpretability and generalisability. Scientifically and clinically, it could enable more precise risk stratification to guide post-TACE management and trial enrichment.

Guo Y, Zhang G, Fu X et al. · Gut · (2026) · View on PubMed ↗

Post hoc estimation of a quantitative restriction spectrum imaging biomarker for prostate cancer detection using conventional MRI.​

This study evaluated whether restriction spectrum imaging (RSI) metrics can be estimated post hoc from conventional MRI to detect clinically significant prostate cancer (csPCa). Using conventional diffusion-weighted imaging (DWI) as a surrogate for dedicated multi–b-value RSI acquisition, the authors assessed the accuracy/validity of post hoc estimated RSI biomarkers (RSIrs) for csPCa detection (full quantitative results are truncated in the abstract). If validated, this approach could enable automated csPCa detection without requiring specialized RSI acquisition protocols.

Do DD, Conlin CC, Bagrodia A et al. · Journal of applied clinical medical physics · (2026) · View on PubMed ↗

Machine Learning-Based Sleep Electroencephalographic Brain Age Index and Dementia Risk: An Individual Participant Data Meta-Analysis.​

This individual participant data meta-analysis studied whether a machine learning-based sleep electroencephalography (EEG) brain age index (BAI) predicts incident dementia in community-dwelling populations. Pooling sleep data from five longitudinal cohorts, it evaluates the association between deviation of sleep-EEG brain age from chronological age (the sleep BAI) and future dementia risk. The significance is that a scalable, data-driven sleep EEG biomarker could improve dementia risk stratification and early identification in the general population.

Sun H, Milton S, Fang Y et al. · JAMA network open · (2026) · View on PubMed ↗

Use of ctDNA in Older Women with ER+ Breast Cancer to Facilitate Surgical De-escalation: A Prospective, Hybrid-Decentralized Trial with Correlative Studies.​

In a prospective, hybrid-decentralized trial (NCT05914792) enrolling 43 older women with ER+ breast cancer, ctDNA was used to determine whether ctDNA levels predict tumor progression in patients who chose surgical de-escalation (forgoing breast cancer surgery in favor of primary endocrine therapy). ctDNA status/levels were associated with subsequent tumor progression, supporting ctDNA as a prognostic tool to guide safe de-escalation decisions. This could reduce overtreatment in older patients while maintaining oncologic safety through biomarker-guided management.

Carleton N, Chang AC, Chen F et al. · Clinical cancer research : an official journal of the American Association for Cancer Research · (2026) · View on PubMed ↗

Tumor metabolism, lactate/lipids & immunometabolism​

Lactylation Converts ABHD6 into a Mitochondrial Regulator that Drives Lenvatinib Resistance in Hepatocellular Carcinoma.​

This cancer biology study examined how lactylation converts ABHD6 into a mitochondrial regulator that drives lenvatinib resistance in hepatocellular carcinoma (HCC). The authors found that ABHD6 promotes resistance by perturbing mitochondrial dynamics through a ligand-binding allosteric switch at the S148 catalytic site, and the pro-resistance effect was independent of ABHD6 catalytic activity but required non-occupied ABHD6. Clinically, targeting the lactylation-dependent ABHD6 mitochondrial regulatory function could help overcome or prevent lenvatinib resistance in HCC.

Sun Y, Luo C, Yang H et al. · Cancer research · (2026) · View on PubMed ↗

Skeletal muscle metabolism in health and disease: Mechanisms, interventions, and clinical perspectives.​

This review focused on skeletal muscle metabolism in health and disease, detailing mechanisms and interventions relevant to clinical outcomes. It emphasizes that metabolic flexibility—coordinated regulation of glucose uptake, fatty acid oxidation, and amino acid metabolism—depends on signaling networks centered on insulin, AMPK, mTOR, and PGC-1α, and that disruptions lead to mitochondrial dysfunction, lipid dysregulation, and muscle wasting. The scientific significance is that it consolidates actionable molecular targets for interventions in metabolic diseases such as obesity, type 2 diabetes, and sarcopenia.

Lin D, Zhang L, Huang C et al. · iScience · (2026) · View on PubMed ↗

Histone lactylation-driven feedback loop modulates pyrimidine metabolism to promote oral carcinogenesis.​

The study examined how lactate-dependent histone lactylation regulates pyrimidine metabolism to promote oral squamous cell carcinoma (OSCC) using human tissue analyses and mechanistic perturbations in vitro and in vivo. It found that histone lactylation levels were increased in oral leukoplakia and OSCC, and that blocking lactylation via glycolysis inhibitors or silencing LDHA reduced OSCC initiation/progression, supported by CUT&Tag, scRNA-seq, and ChIP-qPCR approaches. This identifies a histone lactylation–metabolism feedback mechanism as a potential therapeutic axis for oral carcinogenesis.

Wang Y, Geng Y, Chen Y et al. · Cell death & disease · (2026) · View on PubMed ↗

Resetting of a tandem microRNA156 enables vegetative perennial growth in rice.​

This study investigated the genetic basis of perennial growth habit in rice by analyzing introgression lines between wild and cultivated rice and mapping the Endless Branches and Tillers locus (EBT1). It found that EBT1 contains tandem microRNA156 genes (MIR156BC) and that the wild allele (EBT1W1943) resets MIR156BC expression in tiller buds through higher chromatin accessibility and lower H3K27me3, enabling floral reversion and vegetative propagation. This provides a specific miRNA locus and epigenetic mechanism that can be used to engineer perennial traits in cultivated rice.

Dai B, Lv D, Chen E et al. · Science (New York, N.Y.) · (2026) · View on PubMed ↗

Gut microbe-derived N-acyl serinol lipids shape host postprandial metabolic homeostasis.​

This study examined the role of gut microbe–derived N-acyl serinol lipids (N-acyl amides) in shaping host postprandial metabolic homeostasis. It reported that these bacterial lipids produced after meals act as signaling molecules that influence host metabolic responses during the postprandial period (details truncated in the abstract). The work supports a specific class of microbiome-derived lipids as potential targets for microbiome-inspired therapies to improve human metabolic regulation.

Dutta S, Mahen KK, Massey WJ et al. · Proceedings of the National Academy of Sciences of the United States of America · (2026) · View on PubMed ↗

A CHKA-PML autophagy checkpoint enables tumors to evade glutamine starvation.​

This study examined how glutamine scarcity affects tumor cell survival by focusing on choline kinase alpha (CHKA) and its downstream target promyelocytic leukemia (PML) in cancer models. The authors found that glutamine deprivation upregulates CHKA monomerization and noncanonical kinase activity, leading to CHKA-mediated phosphorylation of PML at tyrosine 339 and a shift to cytoplasmic PML that blocks SUMO-ubiquitin–linked protein degradation. This CHKA–PML autophagy checkpoint helps tumors evade nutrient stress, identifying a potential metabolic vulnerability to target in glutamine-deprived solid tumors.

Wang R, Cao L, He X et al. · Proceedings of the National Academy of Sciences of the United States of America · (2026) · View on PubMed ↗

Phospholipid Glutathione Peroxidase Overexpression Mitigates Cancer Cachexia by Protecting Muscle Mass and Lowering Inflammation.​

This study evaluated whether overexpressing phospholipid glutathione peroxidase (GPx) mitigates cancer cachexia in experimental models by protecting skeletal muscle mass and reducing inflammation. The key finding is that phospholipid GPx overexpression attenuates cachexia-associated muscle wasting and lowers inflammatory burden, consistent with improved control of oxidative/lipid-peroxidation stress. Scientifically and clinically, it suggests that enhancing phospholipid antioxidant defenses could be a therapeutic strategy to counteract muscle loss and inflammation in cancer cachexia.

Duggan E, Fuqua JD, Hagy B et al. · Journal of cachexia, sarcopenia and muscle · (2026) · View on PubMed ↗

Mitochondrial biology & cell death mechanisms​

FGF21-Mediated Upregulation of SIRT1 Delays Intervertebral Disc Degeneration by Promoting PINK1/Parkin Dependent Mitophagy Through Deacetylation of FOXO3.​

This preclinical study tested whether FGF21-mediated upregulation of SIRT1 delays intervertebral disc degeneration by promoting PINK1/Parkin-dependent mitophagy through deacetylation of FOXO3. In human and rat degenerated intervertebral discs and in vitro models, FGF21 was downregulated and linked to increased senescence markers, while mechanistic experiments supported an FGF21→SIRT1→FOXO3 deacetylation→PINK1/Parkin mitophagy pathway that reduced pathological progression. These findings identify a potentially druggable axis to slow intervertebral disc degeneration by enhancing mitochondrial quality control.

Wu ZL, Ran R, Xie QQ et al. · Aging cell · (2026) · View on PubMed ↗

Apoptotic extracellular vesicles derived from MSCs exposed to hypoxic and inflammatory environments slow intervertebral disc degeneration by enhancing cell activity and regulating immunity microenvironment.​

The study examined whether apoptotic extracellular vesicles (ApoEVs) derived from mesenchymal stem cells (MSCs) exposed to hypoxic and inflammatory conditions can slow intervertebral disc degeneration by modulating nucleus pulposus cell (NPC) activity and the local immune microenvironment. The key finding is that hypoxia/inflammation-conditioned MSC-derived ApoEVs attenuate IVDD progression by enhancing NPC functional activity and regulating the immunity microenvironment. This suggests a cell-free, microenvironment-matched vesicle therapy approach for IVDD where transplanted stem cells are prone to apoptosis.

Zhang W, Ma X, Yin H et al. · Materials today. Bio · (2026) · View on PubMed ↗

Mitoxyperilysis: fasting-induced cell death in immunometabolism and disease.​

This review article describes mitoxyperilysis, a fasting-induced lytic cell death mechanism involving mitochondrial proximity-dependent rupture of the plasma membrane, triggered by immune agonists plus nutrient starvation. The key finding is that mitoxyperilysis links immunometabolism to a distinct, therapeutically targetable death pathway relevant to sepsis and cancer. Scientifically, it reframes how immune activation and metabolic stress cooperate to drive cell death, potentially guiding new interventions.

Al-Zidan R, Gautam M, Man SM · Trends in biochemical sciences · (2026) · View on PubMed ↗

Transplantation of encapsulated mitochondria alleviates dysfunction in mitochondrial and Parkinson's disease models.​

This study investigated mitochondrial transplantation in mice and monkeys by encapsulating mitochondria in vesicles derived from erythrocyte plasma membranes to enhance delivery into somatic tissues. Encapsulated mitochondria complemented loss/deletion/mutations of mitochondrial DNA and rescued bioenergetic and biochemical defects in patient-derived mitochondrial disorder cells. The approach supports a clinically relevant strategy for efficient mitochondrial delivery and functional restoration in mitochondrial disease models.

Du S, Long Q, Zhou Y et al. · Cell · (2026) · View on PubMed ↗

Host-derived nitrate fuels indole production by Escherichia coli to drive chronic kidney disease progression.​

This study examined whether host-derived nitrate supports microbial indole production by Escherichia coli to drive chronic kidney disease (CKD) progression in adenine-induced CKD mice and in fecal samples from CKD patients. It found that impaired clearance of indoxyl sulfate increases mucosal iNOS expression, elevating luminal nitrate that fuels E. coli growth via nitrate respiration, and that CKD patient fecal microbiota generate more indole than healthy controls under anaerobic conditions. These results connect host iNOS–nitrate metabolism to E. coli–indole/indoxyl sulfate pathways, identifying a potential metabolic lever for slowing CKD progression.

Lee JY, Mahan SP, Parente de Carvalho T et al. · Science (New York, N.Y.) · (2026) · View on PubMed ↗

Disruption of iron homeostasis by HERC2-FTL axis leads to chondrocyte loss and exacerbates osteoarthritis.​

This study examined how the HERC2–FTL axis disrupts iron homeostasis to drive ferroptosis and cartilage loss in osteoarthritis using ATDC5 chondrocytes treated with IL-1β or the ferroptosis inducer erastin. It reports that altering HERC2 (knockdown/overexpression) modulates ferroptosis, autophagy, oxidative stress, and expression of cartilage matrix proteins, and that HERC2-driven iron dysregulation exacerbates chondrocyte loss. The findings are significant because they identify an upstream HERC2–iron/FTL regulatory pathway that could be targeted to prevent ferroptosis-mediated OA progression.

Zhong Y, Duan J, Chen Z et al. · Apoptosis : an international journal on programmed cell death · (2026) · View on PubMed ↗

The therapeutic potential of Piezo1 channel-mediated ferroptosis and its inhibitor.​

This review article studied the mechanistic link between Piezo1, mechanically activated Ca2+ influx, and ferroptosis, and evaluated the therapeutic potential of inhibiting this pathway. It reports that Piezo1 activation promotes iron uptake and ferritinophagy (via TfR1, DMT1, and NCOA4), increases ROS and lipid peroxidation, and thereby triggers glutathione-dependent ferroptosis execution. The scientific significance is that Piezo1-mediated ferroptosis provides a druggable mechanotransduction-to-cell-death axis, supporting development of Piezo1 inhibitors as potential ferroptosis-targeted therapies.

Nan K, Zhang L, Zhao Y et al. · Apoptosis : an international journal on programmed cell death · (2026) · View on PubMed ↗

Cardiovascular disease risk stratification & mechanistic targets​

Fibrinogen-Bmal1 signaling as a therapeutic target to limit aortic dissection by preserving VSMC contractility.​

The study tested fibrinogen–Bmal1 signaling as a therapeutic target to limit aortic dissection progression by preserving vascular smooth muscle cell (VSMC) contractility, using patient-linked analyses and experimental validation. It found that higher fibrinogen levels were associated with improved outcomes in acute aortic dissection and that fibrinogen–Bmal1 signaling can be leveraged to maintain VSMC contractile function to slow disease progression. This provides a translational rationale for targeting the fibrinogen/Bmal1 axis as a pharmacologic strategy for aortic dissection beyond surgery.

Zhong X, Li D, Zhao Y et al. · Signal transduction and targeted therapy · (2026) · View on PubMed ↗

Heart failure & cytoskeletal remodeling targets​

Inhibiting RhoA Activation Via GDP-State Stabilization to Relieve Heart Failure.​

The study investigated a RhoA activation inhibitor designed to stabilize RhoA in its GDP-bound state to relieve pathological remodeling in heart failure models. Using structural comparisons of RhoA-GTP versus RhoA-GDP conformations and surface plasmon resonance-based screening, the authors identified a druggable RhoA inhibitor that suppresses RhoA activation and improves heart failure phenotypes. This provides a mechanistically targeted strategy to inhibit RhoA-driven cytoskeletal remodeling and fibrosis/hypertrophy, addressing the long-standing “undruggable” nature of RhoA.

Xue M, Liang Y, Yuan Z et al. · Circulation research · (2026) · View on PubMed ↗

Pulmonary hypertension & cardiopulmonary outcomes​

Prognostic Impact of Elevated Pulmonary Vascular Resistance in Group 2 Pulmonary Hypertension: Insights From a Japanese Multicenter Registry.​

This Japanese multicenter registry analysis assessed the prognostic impact of elevated pulmonary vascular resistance (PVR) in group 2 pulmonary hypertension (PH) due to left heart disease using two prospective registries (2012–2016 and 2018–2024; total n=988). The study evaluated composite outcomes including heart-failure hospitalization, all-cause death, ventricular assist device implantation, and cardiac transplantation, and examined how PVR relates to prognosis and implications for emerging therapies. The results support using PVR for risk stratification in group 2 PH and may guide selection and evaluation of future treatment strategies.

Satoh T, Sugimura K, Fukumoto Y et al. · Journal of the American Heart Association · (2026) · View on PubMed ↗

Neurology: neurodegeneration, neuroimmune circuits & pain​

Postural Orthostatic Tachycardia Syndrome, Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Long COVID as Neuroimmune Disorders.​

This article reviewed the concept that postural orthostatic tachycardia syndrome (POTS), myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), and Long COVID represent neuroimmune disorders with overlapping mechanisms. It highlights key mechanistic contributors including autonomic dysfunction, immune dysregulation/autoimmunity, mitochondrial dysfunction, cerebral hypoperfusion, and neuroinflammation. The clinical significance is that grouping these syndromes as neuroimmune conditions may help unify research targets and therapeutic strategies.

Blitshteyn S, Doherty TA, Steinman L · ImmunoTargets and therapy · (2026) · View on PubMed ↗

Cryo-EM structure of TRPM1 reveals a non-canonical architecture with an inverted transmembrane domain.​

The study used cryogenic electron microscopy (cryo-EM) to determine the structure of the vision-related membrane protein TRPM1 in the context of congenital stationary night blindness. It found that TRPM1 forms a non-canonical architecture with an inverted transmembrane domain while maintaining a canonical tetrameric fold in the intracellular domain. This structural resolution clarifies how TRPM1 may function as an ion channel and informs interpretation of TRPM1 mutations underlying retinal disease.

Fabrizio M, Brewer M, Bogdanović N et al. · Nature communications · (2026) · View on PubMed ↗

Commensal-driven serotonin production modulates in vivo delivery of synthetic and viral vectors.​

This study examined how gut microbiota–driven serotonin production affects in vivo delivery efficiency of intestinal epithelial–to–Kupffer cell signaling for synthetic and viral vectors in vivo. It found that disrupting commensal-host interactions or transiently suppressing serotonin signaling (via receptor blockade or dietary intervention) reduces hepatic IDS clearance and increases vector delivery efficiency by more than threefold. These results identify a microbiome–serotonin axis as a tractable target to improve systemic drug and gene delivery outcomes.

Wang Q, Chen Z, Zhang G et al. · Science (New York, N.Y.) · (2026) · View on PubMed ↗

A sympathetic-eosinophil axis orchestrates psychological stress to exacerbate skin inflammation.​

This study examined in mice how psychological stress alters immune responses in skin by focusing on prodynorphin-positive (Pdyn+) noradrenergic sympathetic neurons and their effects on eosinophils in atopic dermatitis-like models. It found that genetic ablation of Pdyn+ sympathetic neurons or eosinophils mitigated stress-induced worsening of skin inflammation, while optogenetic activation of Pdyn+ neurons precipitated inflammation via eosinophils through a CCL11–CCR3 recruitment axis. These findings define a sympathetic–eosinophil circuit as a mechanistic bridge between stress and exacerbated dermatitis.

Tian J, Cao Y, Li Y et al. · Science (New York, N.Y.) · (2026) · View on PubMed ↗

Hypothalamic clock governs circadian pain.​

This study investigated how the hypothalamic master circadian clock controls circadian variation in pain in a mouse model of neuropathic pain. It found that daily oscillations in nociceptive thresholds are driven by a circuit from suprachiasmatic nucleus VIP neurons (SCNVIP) to paraventricular nucleus (PVN) and ventrolateral periaqueductal gray (vlPAG), where higher daytime VIP activity increases nociceptive sensitivity and reduced nighttime activity decreases pain. This mechanistic framework links specific hypothalamic clock outputs to rhythmic pain processing and suggests timing-aware targets for analgesic strategies.

Wei HR, Lou Q, Li LX et al. · Science (New York, N.Y.) · (2026) · View on PubMed ↗

From chronic pain to depression: Neurogenesis-driven microglial remodeling in the hippocampal dentate gyrus.​

This study investigated how chronic pain transitions to depression by integrating UK Biobank human neuroimaging with a rodent model to track hippocampal dentate gyrus (DG) remodeling. It found a biphasic pattern where hippocampal volume increases early (with cognitive improvements) but declines with comorbid depression, and in rodents DG lesions prevented affective symptoms while DG hyperactivity drove hyperactive newborn neurons, microglial recruitment, and circuit imbalance. These findings implicate neurogenesis-driven microglial remodeling in the DG as a causal mechanism for pain-associated affective dysfunction.

Ding M, Xiang S, Zhang Y et al. · Science (New York, N.Y.) · (2026) · View on PubMed ↗

Astrocytes at the crossroads of obstructive sleep apnea and Alzheimer's disease: from oxygen sensing to neurodegeneration.​

This review article explored how astrocytes may mechanistically connect obstructive sleep apnea (OSA) to Alzheimer’s disease (AD), emphasizing oxygen sensing and downstream neurodegeneration. The authors synthesized evidence that intermittent hypoxia and sleep fragmentation can drive astrocyte dysfunction and contribute to AD-relevant pathways such as neuroinflammation and neurodegenerative signaling. By framing astrocytes as a mechanistic bridge between OSA and AD, the review highlights potential targets for intervention in sleep-related drivers of neurodegeneration.

Cabot J, Soriano JB, Alonso-Fernández A et al. · Sleep & breathing = Schlaf & Atmung · (2026) · View on PubMed ↗

Interplay of oxidative stress and neuroinflammation in alzheimer's: insights into age-driven pathogenesis.​

This review analyzed the interplay between oxidative stress and neuroinflammation in Alzheimer’s disease (AD) with a focus on age-driven pathogenesis. It highlighted mitochondrial dysfunction and reactive oxygen species (ROS)–mediated redox imbalance that promotes amyloid-β accumulation and cognitive decline, alongside chronic inflammasome activation in microglia and astrocytes involving NLRP3 and NF-κB signaling. The synthesis supports targeting combined oxidative and inflammatory pathways as a strategy to modify AD progression in aging populations.

Firdous SM, Chakrabortty S, Undale VR et al. · Inflammopharmacology · (2026) · View on PubMed ↗

Therapeutic Potential of Somatostatin and Its Analogues in Alzheimer's Disease: From Molecular Mechanisms to Preclinical Studies.​

This review studied the therapeutic potential of somatostatin (SST) and somatostatin analogues (SSAs) in Alzheimer’s disease, integrating molecular mechanisms and preclinical evidence. It reports that SST receptors (SSTR1–5) influence amyloid-β metabolism, tau phosphorylation, neuroinflammation, and synaptic plasticity, and that SSAs may enhance amyloid clearance (e.g., via neprilysin activation) and reduce tau-related pathology in preclinical models. The significance is that SSAs represent multitarget candidates that could modify disease-relevant pathways beyond symptomatic treatments currently approved for AD.

Liu K, Zhang XY, Wang YT et al. · Molecular neurobiology · (2026) · View on PubMed ↗

Transcriptomic Insights Into Alzheimer's Disease: Differentially Expressed Genes and Cholesterol Metabolism.​

This computational study used Mendelian randomization and advanced machine learning on transcriptomic data to investigate differentially expressed genes and cholesterol metabolism pathways in Alzheimer disease (AD). The analysis identified AD-associated gene expression differences linked to cholesterol-related mechanisms, suggesting cholesterol metabolism as a key molecular contributor. These results support cholesterol-centered biomarkers and therapeutic hypotheses for improving AD early detection and mechanistic understanding.

Sun R, Wang X, Wang Z et al. · CNS neuroscience & therapeutics · (2026) · View on PubMed ↗

Early-Life Melatonin Supplementation Reduces the Long-Term Behavioral, Morphological, and Molecular Alterations in a Rat Model of Autism Spectrum Disorder.​

This preclinical study tested whether early-life melatonin supplementation alters long-term outcomes in a rat model of autism spectrum disorder (ASD), assessing behavioral, morphological, and molecular changes after melatonin administration. The key finding is that early melatonin reduces the later behavioral deficits and associated morphological and molecular abnormalities seen in ASD-model rats. These results support melatonin as a potentially disease-modifying early intervention candidate targeting circadian and anti-inflammatory/antioxidant pathways relevant to ASD comorbid sleep and neuroinflammation.

Hernández-Sierra LJ, Salgado-Delgado RC, Ibáñez-Sandoval O et al. · Journal of pineal research · (2026) · View on PubMed ↗

Neurodevelopmental/psychiatric disorders & microbiome–brain axis​

How gut microbiota contribute to neuropsychiatric disorders: evidence from neuroimaging studies.​

This review summarized how gut microbiota contribute to neuropsychiatric disorders using evidence from neuroimaging studies. It reports that multimodal imaging modalities—such as magnetic resonance imaging, positron emission tomography, and diffusion tensor imaging—can visualize associations between microbiome alterations and brain structure/function changes across neurodevelopmental, neurodegenerative, autoimmune, and psychiatric conditions. The scientific significance is that it frames the microbiota–gut–brain axis as an in vivo, imaging-accessible pathway for generating testable mechanistic hypotheses.

Jia C, Zhu W, Yuan Y et al. · Frontiers in microbiology · (2026) · View on PubMed ↗

Infectious disease virology & host factors​

LRP8 is a functional receptor for yellow fever virus.​

The study investigated host receptor usage for yellow fever virus (YFV) and identified LRP8 (APOER2) as a functional receptor. Using a barcoded, genome-wide human open-reading frame library screen, the authors found that LRP8 expression increases infection by the live-attenuated 17D vaccine strain and clinical strains (BJ01 and Asibi) by promoting viral entry, and that adeno-associated virus-mediated LRP8 expression in mouse liver worsened infection/pathology of the BJ01 strain. This is clinically significant for understanding YFV tropism and for anticipating how receptor expression may influence vaccine and infection outcomes.

Mei M, Yang Y, Zhang Z et al. · Nature microbiology · (2026) · View on PubMed ↗

ALG6 orchestrates coronavirus replication via the endoplasmic reticulum stress-autophagy axis.​

This study investigated the host factor alpha-1,3-glucosyltransferase ALG6 in coronavirus replication, using transmissible gastroenteritis virus (TGEV) and host-cell genetic perturbations. ALG6 catalytic activity was required for TGEV replication, and ALG6 knockout inhibited viral entry by downregulating the receptor aminopeptidase N (ANPEP) while also triggering endoplasmic reticulum (ER) stress that further suppressed viral replication. These findings position ALG6 as a druggable ER-stress–autophagy axis regulator of coronavirus life cycle and entry.

Fu Y, Gao M, Fu Z et al. · Cell reports · (2026) · View on PubMed ↗

Diagnostic Performance of Anti-Epstein-Barr Virus BNLF2b in Suspected Nasopharyngeal Carcinoma.​

This prospective, multicenter outpatient diagnostic study compared the diagnostic performance of an anti–Epstein-Barr virus (EBV) BNLF2b total antibody assay (P85-Ab) against EBV VCA-IgA, EBV EA-IgA, and EBNA1-IgA in suspected nasopharyngeal carcinoma (NPC). The P85-Ab assay showed superior or more reliable diagnostic accuracy for suspected NPC in the outpatient setting compared with the other EBV serologic markers. Clinically, this supports adopting P85-Ab as a more effective blood-based biomarker to improve early NPC detection and reduce misdiagnosis.

Li SC, Li FG, Wu SJ et al. · JAMA oncology · (2026) · View on PubMed ↗

Clinical trials, guidelines & real-world evidence (non-oncology)​

Embedded CRISPRi Enhances Gene-Silencing Efficiency in Drosophila.​

This study developed embedded CRISPR interference (emCRISPRi) in Drosophila melanogaster by engineering transcriptional repression domains (Mxi and TRD) into a flexible region of catalytically inactive Cas9 (dCas9). emCRISPRi significantly increased gene-silencing efficiency and repression amplitude, especially for coding genes and cis-regulatory elements near transcription start sites (TSS-proximal regions). The platform improves the reliability of CRISPRi in Drosophila, enabling more effective functional genomics screens.

Fu P, Zhang X, Zhou Y et al. · Advanced science (Weinheim, Baden-Wurttemberg, Germany) · (2026) · View on PubMed ↗

Tavapadon as Adjunctive Treatment for Parkinson Disease: The TEMPO-3 Randomized Clinical Trial.​

This randomized clinical trial evaluated tavapadon, an investigational once-daily selective D1/D5 agonist, as adjunctive therapy to oral levodopa in adults with Parkinson disease experiencing motor fluctuations. The study was designed to assess tavapadon’s efficacy, safety, and tolerability, aiming to improve motor control while reducing adverse events associated with preferential D2/D3 receptor activation. If effective, tavapadon could offer a mechanism-targeted adjunct strategy for managing levodopa-induced motor fluctuations with a potentially improved safety profile.

Fernandez HH, Isaacson SH, Hauser RA et al. · JAMA neurology · (2026) · View on PubMed ↗

Trends in 5-year net survival for women diagnosed with breast, cervical or ovarian cancer in Japan, 2000-14 (CONCORD-3).​

Using Japanese population-based cancer registry data from the CONCORD-3 program, this study analyzed 5-year net survival trends for women diagnosed with breast, cervical, or ovarian cancer between 2000 and 2014 (ages 15–99), excluding in situ and death-certificate-only cases. The authors reported long-term survival patterns stratified by cancer type and other factors across the 2000–2014 diagnosis period. These surveillance findings help quantify progress and remaining gaps in cancer outcomes for women in Japan and can inform public health and clinical prioritization.

Watanabe K, Di Carlo V, Sugiyama H et al. · Japanese journal of clinical oncology · (2026) · View on PubMed ↗

Stroke Risk After Bioprosthetic Aortic Valve Replacement in Aortic Stenosis: Systematic Review and Meta-Analysis.​

This systematic review and meta-analysis estimated the proportion of adults (>18 years) who experienced ischaemic stroke after bioprosthetic aortic valve replacement for aortic stenosis, including periprocedural and beyond-periprocedural periods across transcatheter AVR (TAVR), surgical AVR, and valve-in-valve (ViV) replacement. The authors searched MEDLINE, Embase, and Web of Science through March 2024 and synthesized studies reporting post-bioprosthetic AVR stroke incidence. The pooled estimates provide clinically actionable risk benchmarks for counselling, monitoring, and designing strategies to reduce stroke after AVR.

Bou Dargham T, Hassani S, Mac Grory BC et al. · Stroke · (2026) · View on PubMed ↗

Joint TOS/OMA/OAC expert guidance statement on the pharmacological management of United States adults with overweight or obesity using the GRADE approach.​

This article developed an expert guidance statement for pharmacological management of United States adults with overweight or obesity using the GRADE approach. It synthesizes evidence and provides updated recommendations to improve access and appropriate use of FDA-approved anti-obesity medications while addressing barriers such as clinician training, stigma, and reimbursement limitations. The guidance is clinically significant because it standardizes evidence-based obesity treatment decisions at the population level in the US.

Alexander L, Purnell JQ, Burridge K et al. · Obesity pillars · (2026) · View on PubMed ↗

Glucagon-like peptide-1 receptor agonists for major cardiovascular and kidney outcomes in type 1 diabetes.​

This study assessed long-term cardiovascular and kidney outcomes of glucagon-like peptide-1 receptor agonists (GLP-1RAs) in type 1 diabetes using national electronic health record data. In a sequential target trial emulation of 174,678 patients (2013–2024), GLP-1RA initiation was associated with lower risk of major adverse cardiovascular events and end-stage kidney disease after propensity score weighting. The clinical significance is that it provides real-world evidence supporting GLP-1RA benefit for cardiovascular and renal protection in type 1 diabetes, where long-term randomized outcome data have been limited.

Xu Y, Malek ND, Chang AR et al. · Nature medicine · (2026) · View on PubMed ↗

Type 2 diabetes mellitus.​

This Nature Reviews Disease Primer summarized the epidemiology, risk factors, and clinical course of type 2 diabetes mellitus (T2DM) across human populations, emphasizing the roles of genetics, biology, behavior, and social determinants. It highlighted that rising obesity has shifted T2DM epidemiology and that early-onset T2DM (diagnosis over 40 years) is linked to more aggressive progression, higher complication burden, and greater lifetime morbidity than later-onset disease. The review is clinically significant for guiding prevention and risk stratification strategies tailored to modern, younger T2DM populations.

Davies MJ, Lim S, Slater T et al. · Nature reviews. Disease primers · (2026) · View on PubMed ↗

Adherence to the EAT-Lancet Diet and Risk of Sepsis: A Prospective Cohort Study from the UK Biobank.​

The study analyzed whether adherence to the EAT-Lancet diet is associated with sepsis risk in 199,085 participants from the UK Biobank, incorporating genetic susceptibility and proteomic mechanisms. It found that higher EAT-Lancet diet adherence was associated with a reduced risk of sepsis (HR 0.85, 95% CI 0.78, as reported in the abstract). This supports dietary pattern modification as a potential modifiable factor for sepsis prevention and motivates mechanistic work linking diet, host biology, and proteomic pathways.

Nan W, Huang Q, He B et al. · NPJ science of food · (2026) · View on PubMed ↗

Clinical practice guideline for long COVID prevention and treatment.​

This European respiratory society guideline synthesized evidence to provide recommendations for long COVID prevention and treatment in adults with long COVID for use by clinicians and community healthcare providers. The key finding is the establishment of a structured, protocol-driven guideline addressing key clinical questions and translating evidence into practice recommendations. Its significance is to standardize care pathways for long COVID globally and reduce variability in prevention and management.

Cao B, Soriano JB, Wang Q et al. · The European respiratory journal · (2026) · View on PubMed ↗

Anifrolumab in systemic lupus erythematosus: real-world evidence from a Spanish multicentre cohort of 206 patients and literature review.​

This Spanish multicenter real-world study of 206 adults with moderate-to-severe active systemic lupus erythematosus (SLE) assessed anifrolumab effectiveness and safety and compared findings with published observational evidence. The key finding is that anifrolumab showed real-world effectiveness and an acceptable safety profile consistent with prior trial data. Clinically, these data support decision-making for anifrolumab use in routine practice beyond randomized controlled trials.

Calvo-Río V, Secada-Gómez C, Martín Gutiérrez A et al. · RMD open · (2026) · View on PubMed ↗

The efficacy and safety of cannabinoids for the treatment of mental disorders and substance use disorders: a systematic review and meta-analysis.​

This systematic review and meta-analysis evaluated randomized controlled trials of cannabinoids as primary treatment for mental disorders and substance use disorders (SUDs). The key finding is an evidence synthesis of efficacy and safety across included trials, clarifying the overall balance of benefits and harms for cannabinoid-based interventions. Clinically, it informs whether cannabinoids should be used for psychiatric/SUD indications and highlights where evidence remains uncertain.

Wilson J, Dobson O, Langcake A et al. · The lancet. Psychiatry · (2026) · View on PubMed ↗

Epidemiology, ventilation, and outcomes of acute respiratory failure in immunocompromised patients from 103 intensive care units in 26 countries: a retrospective observational study.​

This retrospective observational study analyzed acute respiratory failure (ARF) in immunocompromised adults across 103 intensive care units in 26 countries to characterize epidemiology, ventilation strategies, and outcomes. The key finding is identification of predictors of mortality and intubation in this immunocompromised ARF population, linked to underlying immunosuppression and oxygenation/ventilation approaches. The significance is improved risk prediction and benchmarking of ICU management for immunocompromised patients with ARF.

Azoulay E, McEvoy C, Castro P et al. · The Lancet. Respiratory medicine · (2026) · View on PubMed ↗

Integration of Epidemiology and Network Toxicology Revealed the Arrhythmogenic Potential of Neonicotinoid Insecticides.​

This study integrated epidemiology and network toxicology to assess arrhythmogenic potential of neonicotinoid insecticides by measuring urinary neonicotinoids and metabolites in 136 arrhythmia patients and 222 healthy controls. Neonicotinoids were detected in all samples with higher concentrations in patients than controls (except thiamethoxam and clothianidin), and quantile g-computation and Bayesian kernel machine regression suggested that co-exposure to multiple neonicotinoids increased arrhythmia risk. The findings indicate that mixture exposure to neonicotinoids may be a meaningful contributor to human arrhythmia risk and can be prioritized for risk assessment.

Ge Y, Xiao Q, Fu B et al. · Environmental science & technology · (2026) · View on PubMed ↗

Preferences in Cyclin-Dependent Kinase 4/6 Inhibitors for Advanced Breast Cancer Among Medical Oncologists in Latin America.​

This cross-sectional survey studied Latin American medical oncologists’ preferences for cyclin-dependent kinase 4/6 inhibitors (CDK4/6i) in advanced hormone receptor-positive, HER2-negative breast cancer. Among 116 oncologists from 15 countries, ribociclib was the preferred agent (56.8%), with preferences shaped by drug availability and clinical decision-making across scenarios. The results highlight regional prescribing patterns and access-driven differences that may affect real-world CDK4/6i utilization and patient outcomes.

Villarreal-Garza C, Meraz-Brenez A, Reyes Morales A et al. · JCO global oncology · (2026) · View on PubMed ↗

Efficacy and Safety of Remimazolam Tosylate versus Propofol for Sedation of Postoperative Mechanically Ventilated Patients in Intensive Care Units: a Multicenter, Randomized, Single-blind, Non-inferiority, Phase 3 trial.​

This multicenter, randomized, single-blind phase 3 trial compared intravenous remimazolam tosylate versus propofol for sedation in postoperative mechanically ventilated ICU patients. Patients were randomized to remimazolam tosylate (loading 0.08 mg/kg; maintenance 0–2.0 mg/kg/h) or propofol (loading 0.3–0.5 mg/kg; maintenance 0.3–4.0 mg/kg/h) targeting RASS -2 to 1, with non-inferiority as the primary framework (outcomes truncated in the provided abstract). If non-inferiority and safety were confirmed, remimazolam could offer an alternative short-acting benzodiazepine-based sedation strategy for mechanically ventilated ICU patients.

Guan X, Liu N, Lin F et al. · Anesthesiology · (2026) · View on PubMed ↗

Velocity Loss During Resistance Training: Implications for Concurrent Training Adaptations.​

This randomized study examined how different resistance-training velocity loss (VL) thresholds (0%, 15%, 40%) affect adaptations to concurrent training, compared with endurance training alone, in 41 moderately trained men. Over 8 weeks, participants performed squat-based resistance training at 70–85% 1RM followed by running endurance training, and the study assessed strength, endurance, neuromuscular, and hypertrophic outcomes (specific results truncated in the provided abstract). The work informs how manipulating VL during resistance training may optimize or preserve adaptations during concurrent training.

Tundidor-Duque RM, Loturco I, Paéz-Maldondado JA et al. · Scandinavian journal of medicine & science in sports · (2026) · View on PubMed ↗

The relationship between sarcopenia and all-cause and cardiovascular mortality risk among middle-aged and older adults across stages 0-3 of cardiovascular-kidney-metabolic syndrome: evidence from NHANES and CHARLS.​

This study used NHANES (2011–2018) and CHARLS (2011–2020) to investigate whether sarcopenia predicts all-cause and cardiovascular mortality across stages 0–3 of cardiovascular-kidney-metabolic (CKM) syndrome in middle-aged and older adults. Using multivariable Cox regression (details truncated in the provided abstract), it aimed to quantify the mortality risk associated with sarcopenia within CKM strata. The findings could support sarcopenia as a prognostic marker for mortality risk and help refine risk stratification in CKM syndrome.

Chen Y, Liu Y, Liu S et al. · Cardiorenal medicine · (2026) · View on PubMed ↗

A neuroimmune circuit links stress to skin inflammation.​

This Science study investigated a neuroimmune circuit linking stress to skin inflammation, focusing on sympathetic neurons and eosinophils in the context of atopic dermatitis. It reported that sympathetic neurons activate eosinophils during stress, worsening atopic dermatitis flare-ups. The mechanism identifies a stress-to-immunity pathway that could be targeted to prevent or treat inflammatory skin exacerbations.

Gaudenzio N, Basso L · Science (New York, N.Y.) · (2026) · View on PubMed ↗

Association between COVID-19 vaccination and sudden death in apparently healthy younger individuals: A population-based case-control study.​

This population-based case-control study assessed whether COVID-19 vaccination is associated with sudden death in apparently healthy younger individuals aged 12–50 years in Ontario, Canada using linked administrative datasets. The key finding was the presence/absence of an association between vaccination exposure and sudden death risk after accounting for exclusions and study design constraints (details truncated in the abstract). If confirmed, the results would directly inform vaccine safety surveillance and risk communication for rare but serious outcomes in younger adults.

Abdel-Qadir H, Bhatt HA, Swayze S et al. · PLoS medicine · (2026) · View on PubMed ↗

Phase separation of Rht8-derived RNHL1 integrates ethylene and gibberellin signaling to regulate wheat internode elongation.​

This study examined how the wheat semi-dwarfing gene Rht8, which encodes RNHL1 (Ribonuclease H-like 1), regulates internode elongation by integrating ethylene and gibberellin signaling. The authors found that RNHL1 undergoes liquid-liquid phase separation via intrinsically disordered regions to form nuclear condensates and physically interacts with the ethylene signaling transcription factor TaEIL1 to create functional transcriptional hubs. This mechanistic link between RNHL1 phase separation and hormone crosstalk provides a molecular framework for breeding and engineering wheat height control.

Dong C, Cheng X, Yuan M et al. · The Plant cell · (2026) · View on PubMed ↗

Ritlecitinib for Severe Alopecia Areata: A 24-Week, Multicentre, Real-World Study.​

This real-world observational study evaluated ritlecitinib, an oral JAK3 and TEC-family kinase inhibitor, in patients with severe alopecia areata (SALT ≥ 50) aged ≥12 years in an Italian multicenter retrospective cohort with 24-week follow-up. The key finding was the effectiveness and tolerability of ritlecitinib 50 mg/day over 24 weeks in routine clinical practice (specific response rates and adverse-event outcomes are truncated in the abstract). These data extend evidence for ritlecitinib beyond trials by informing clinicians about real-world benefit-risk in severe disease.

Starace M, Rapparini L, Pampaloni F et al. · American journal of clinical dermatology · (2026) · View on PubMed ↗

MASLD as a systemic metabolic disease: expanding the scope of cardiovascular-kidney-metabolic (CKM) syndrome.​

This article reviewed metabolic dysfunction-associated steatotic liver disease (MASLD) as a systemic disease and argued for its inclusion within the cardiovascular–kidney–metabolic (CKM) syndrome framework. The authors highlighted that MASLD increases cardiovascular and renal risk through shared mechanisms including insulin resistance, low-grade inflammation, oxidative stress, atherogenic dyslipidemia, and a procoagulant state. Recognizing MASLD as part of CKM syndrome could improve screening and integrated management across cardiology and nephrology.

Zhou XD, Fan QY, Targher G et al. · Science China. Life sciences · (2026) · View on PubMed ↗

Managing Bone Fragility in Older Adults with Diabetes: Pathophysiology, Assessment, and Therapeutic Considerations.​

This review summarized how diabetes in older adults contributes to bone fragility and fracture risk, contrasting type 1 diabetes (T1D) and type 2 diabetes (T2D) mechanisms. The authors emphasized that T1D typically lowers bone mineral density via insulinopenia, whereas T2D may preserve or increase BMD but impairs bone quality through microarchitectural changes, advanced glycation end products (AGEs), and altered bone turnover. The clinical significance is improved assessment and therapeutic decision-making for fracture prevention tailored to diabetes type and bone phenotype.

Bahat G, Erdogan T, Ozturk S et al. · Drugs & aging · (2026) · View on PubMed ↗

International Expert Opinion on Optimal Switching to Cladribine Tablets from Other High-Efficacy Disease-Modifying Therapies for Relapsing-Remitting Multiple Sclerosis: Opportunities and Challenges.​

This international expert-opinion review studied optimal treatment sequencing for relapsing-remitting multiple sclerosis (RMS) when switching to cladribine tablets (CladT) from other high-efficacy disease-modifying therapies, including S1P modulators, natalizumab, or anti-CD20 agents. It concludes with practical recommendations on how to time and manage switching to CladT to balance efficacy with safety risks such as immune reconstitution–related complications. The guidance is clinically significant because it addresses a major evidence gap in RMS when transitioning between potent DMT classes.

Chan A, Alroughani R, Calabrese M et al. · Neurology and therapy · (2026) · View on PubMed ↗

Proteomic analyses of human islets reveal potential markers of β-cell dysfunction during prediabetes.​

This study investigated proteomic predictors of β-cell dysfunction during prediabetes by analyzing human pancreatic islets from non-diabetic subjects with known glucose tolerance phenotypes. Using laser capture microdissection (LCM) and high-performance liquid chromatography–mass spectrometry (HPLC-MS), it found that impaired glucose tolerance (IGT) is associated with reduced proteins involved in glycolysis (e.g., PGK1, G3P) and lipid/glucose handling (e.g., ACBP, ARF1), alongside broader proteome shifts linked to early β-cell stress. The clinical significance is that these islet proteomic markers could help predict diabetes onset and identify early biological targets for preventing progression from prediabetes to type 2 diabetes.

Cefalo CMA, Mezza T, Quero G et al. · JCI insight · (2026) · View on PubMed ↗

Transradial vs Transfemoral Access for Cerebral Angiography: A Randomized Noninferiority Clinical Trial.​

This randomized noninferiority clinical trial studied whether transradial access (TRA) is as effective and safe as transfemoral access (TFA) for diagnostic cerebral angiography. Conducted at 13 sites in China with blinded outcome assessment, it compared TRA vs TFA in patients undergoing cerebral angiography to test noninferiority on efficacy and safety endpoints. The clinical significance is that it directly informs access-site choice for cerebral angiography, potentially improving patient comfort and procedural safety if TRA performs comparably.

Ni W, Yang H, Su J et al. · JAMA network open · (2026) · View on PubMed ↗

Meat Consumption and Cognitive Health by APOE Genotype.​

This population-based cohort study in the Swedish National Study on Aging and Care-Kungsholmen (SNAC-K) tested whether meat consumption is associated with cognitive health differently by APOE genotype (APOE ε3/ε4 vs ε4/ε4, and other genotypes). Higher meat consumption was associated with cognitive health benefits specifically in individuals carrying APOE ε4 (APOE34/44), with genotype-dependent differences compared with non-ε4 genotypes. These findings support genotype-informed dietary prevention strategies for Alzheimer disease risk in older adults.

Norgren J, Carballo-Casla A, Grande G et al. · JAMA network open · (2026) · View on PubMed ↗

Bireociclib Plus Fulvestrant in Advanced Breast Cancer After Endocrine Progression: The BRIGHT-2 Phase 3 Randomized Clinical Trial.​

In a double-blind, placebo-controlled phase 3 randomized clinical trial conducted at 64 hospitals in China, bireociclib (a CDK4/6 inhibitor) plus fulvestrant was evaluated in patients with hormone receptor–positive, ERBB2 (HER2)-negative advanced breast cancer after endocrine progression. The final analysis (with additional follow-up) confirmed that bireociclib plus fulvestrant improved efficacy and maintained a manageable safety profile versus placebo plus fulvestrant. This provides clinically actionable evidence for using bireociclib-based therapy to extend outcomes after endocrine therapy failure in HR+/ERBB2− advanced breast cancer.

Wang J, Zhang Q, Li H et al. · JAMA oncology · (2026) · View on PubMed ↗

Women with epilepsy: Evidence-based counseling across the lifespan.​

This evidence-based review synthesized current data on women with epilepsy (WWE) across the lifespan, focusing on counseling needs spanning adolescence, transition to adult care, reproductive health, contraception, fertility and pregnancy, lactation, menopause, and bone health. The review highlights persistent gaps in integrating sex- and life-stage–specific epilepsy management into routine clinical care and aligns recommendations with contemporary guidelines. Scientifically and clinically, it provides a structured framework to improve individualized counseling and management beyond seizure control for WWE.

Tettenborn B, Ramantani G, Flügel D et al. · Epilepsia · (2026) · View on PubMed ↗

Identification and Validation of miR-206-3p Targeting WT-1 Promotes Membranous Nephropathy Through a Comprehensive Bioinformatics and Machine Learning Algorithm.​

Using comprehensive bioinformatics and machine-learning analyses followed by validation, this study identified microRNA-206-3p (miR-206-3p) as a regulator targeting WT-1 (Wilms tumor 1) in membranous nephropathy (MN). miR-206-3p promoted MN by modulating the WT-1–linked molecular network, supported by differential expression across datasets and computationally derived pathway relationships. These results nominate the miR-206-3p/WT-1 axis as a potential mechanistic target for future MN diagnostics or therapeutics.

Wang X, Zhou F, Fu C et al. · FASEB journal : official publication of the Federation of American Societies for Experimental Biology · (2026) · View on PubMed ↗

Onasemnogene Abeparvovec in Type I Spinal Muscular Atrophy: 24-Month Follow-Up From the Italian Registry.​

This prospective observational study followed Italian patients with spinal muscular atrophy type I (SMA I) treated with onasemnogene abeparvovec (AAV9 gene therapy) for 24 months, stratifying outcomes by treatment pathway (monotherapy with OA, bridge from nusinersen or risdiplam, or switch after >3 months). The key finding is that real-world clinical outcomes show response variability beyond what is typically reported in earlier trial follow-up, with differences depending on prior/bridging therapy timing. Clinically, these 24-month registry data help refine expectations for OA effectiveness in routine care and inform how sequencing with nusinersen or risdiplam may influence long-term outcomes.

Pane M, Coratti G, Cutrì C et al. · Annals of clinical and translational neurology · (2026) · View on PubMed ↗

The relationship between dietary patterns and neuroinflammation.​

This review synthesized evidence on how dietary patterns modulate neuroinflammation in the central nervous system by shaping immunometabolic balance, immune signaling, and glial (including microglial) activation. The key finding is that persistent neuroinflammation—driven by microglial activation, chronic pro-inflammatory mediator release, and recruitment of peripheral immune cells—emerges as a common mechanistic link between dietary exposures and multiple neurological/psychiatric disorders. Scientifically, it supports targeting diet composition and timing as modifiable upstream regulators of neuroinflammatory pathways relevant to diseases such as Alzheimer’s disease and major depression.

Medoro A, Scapagnini G, Hu FB et al. · Critical reviews in food science and nutrition · (2026) · View on PubMed ↗

Effects of Diactive-1-Supported Progressive Resistance Training on Body Composition in Youth With Type 1 Diabetes.​

This study assessed the effects of Diactive-1–supported progressive resistance training on body composition in youth with type 1 diabetes (n=62, ages 8–18 years) using an mHealth-supported exercise intervention. The key finding is that resistance training delivered with the Diactive-1 platform can improve specific body composition outcomes in this pediatric population at risk for unfavorable changes in fat, lean, and bone compartments. Clinically, it supports using structured, technology-supported resistance exercise as an actionable strategy to mitigate body composition deterioration in children and adolescents with type 1 diabetes.

Muñoz-Pardeza J, López-Gil JF, Hormazábal-Aguayo I et al. · Journal of cachexia, sarcopenia and muscle · (2026) · View on PubMed ↗

International Dermoscopy Society consensus recommendations for the management of lentigo maligna.​

This article presents International Dermoscopy Society consensus recommendations for managing lentigo maligna (LM), a melanoma in situ subtype common on chronically sun-damaged skin in elderly patients. The key finding is the development of practical, evidence-based guidance for LM diagnosis and management that addresses diagnostic uncertainty and subclinical peripheral extension, including how to use dermoscopy in clinical decision-making. Scientifically and clinically, these consensus recommendations aim to standardize care and improve outcomes by translating limited high-quality evidence into actionable management steps for clinicians.

Forsea AM, Pampena R, Akay BN et al. · Journal of the European Academy of Dermatology and Venereology : JEADV · (2026) · View on PubMed ↗

Other​

Overcoming T cell tolerance to tumor self-antigens through catch-bond engineering.​

This study explored overcoming T cell tolerance to tumor self-antigens by engineering weakly reactive T cell receptors (TCRs) against the nonmutated tumor-associated antigen prostatic acid phosphatase (PAP). It identified a catch-bonding hotspot mutation that increases TCR–pMHC bond lifetime while preserving physiological affinities and antigen fine specificity, leading to markedly improved T cell expansion in tumors, effector differentiation, and tumor elimination. This provides a mechanistically grounded TCR engineering strategy to enhance anti-tumor immunity against self-antigens.

View on PubMed ↗

Generated automatically on March 22, 2026 from PubMed's trending articles. Summaries are AI-generated; always consult the original publication for clinical or research decisions.

Automated digest · 99 articles · 15 research areas · March 21, 2026

Overview​

Recent research trends highlight significant advancements across various medical domains, particularly in cancer therapeutics, cardiovascular health, and metabolic disorders. A substantial number of studies focus on innovative treatment strategies for cancer, including targeted therapies and immunotherapies, which show promise in improving patient outcomes. Additionally, the exploration of metabolic disorders and their implications for conditions like diabetes and obesity is gaining traction, emphasizing the need for integrated approaches to manage these complex health issues.

Moreover, the role of nutrition and dietary interventions is increasingly recognized as a crucial factor in managing chronic diseases, including neurodegenerative disorders and cardiovascular health. The integration of clinical guidelines and recommendations into practice is essential for optimizing patient care, particularly in managing conditions like long COVID and obesity. Overall, the synthesis of these findings underscores the importance of multidisciplinary approaches in advancing healthcare and improving patient outcomes.

Stroke Care and Management​

Effect of a clinical decision support system on stroke care quality and outcomes in patients with acute ischaemic stroke (GOLDEN BRIDGE II): cluster randomised clinical trial.​

This study evaluated the efficacy of a clinical decision support system (CDSS) on stroke care quality and clinical outcomes among 21,603 patients with acute ischaemic stroke across 77 hospitals in China. The key finding was that the CDSS significantly improved stroke care quality and clinical outcomes compared to standard care. This suggests that implementing CDSS can enhance the management of acute ischaemic stroke, potentially leading to better patient outcomes.

Zhang X, Ding L, Jing J et al. · BMJ (Clinical research ed.) · (2026) · View on PubMed ↗

Cancer Therapeutics​

Hijacking ERAD for targeted degradation of transmembrane proteins.​

The study focused on developing a targeted protein degradation technology called ERAD-engaging chimeras (ERADECs) to degrade transmembrane proteins, specifically targeting programmed death-ligand 1 (PD-L1). The key finding was that ERADECs effectively degraded PD-L1 by utilizing desonide as a binder for the E3 ligase SYVN1, demonstrating high efficacy in targeting transmembrane proteins. This advancement in TPD technology could have significant implications for drug discovery and therapeutic interventions in diseases involving PD-L1.

Song H, Wang W, Mei T et al. · Cell · (2026) · View on PubMed ↗

USP25 regulates atherosclerosis by restricting RIPK1-mediated inflammatory responses.​

This research investigated the role of the deubiquitinating enzyme USP25 in atherosclerosis using mouse models with an ApoE-/- background. The key finding was that USP25 was downregulated in atherosclerotic lesions and its expression in macrophages was crucial for regulating inflammatory responses mediated by RIPK1. This suggests that targeting USP25 could be a novel therapeutic strategy for managing atherosclerosis and its associated inflammatory processes.

Su X, Zhou B, Xu Y et al. · EBioMedicine · (2026) · View on PubMed ↗

Lactylation Converts ABHD6 into a Mitochondrial Regulator that Drives Lenvatinib Resistance in Hepatocellular Carcinoma.​

The study examined the role of α/β hydrolase domain containing 6 (ABHD6) in driving resistance to lenvatinib in hepatocellular carcinoma (HCC). The key finding was that lactylation of ABHD6 converted it into a mitochondrial regulator that promotes lenvatinib resistance through non-canonical functions. This highlights the potential of targeting ABHD6 as a therapeutic strategy to overcome resistance in HCC treatment.

Sun Y, Luo C, Yang H et al. · Cancer research · (2026) · View on PubMed ↗

Trends in 5-year net survival for women diagnosed with breast, cervical or ovarian cancer in Japan, 2000-14 (CONCORD-3).​

This research analyzed long-term survival trends for women diagnosed with breast, cervical, or ovarian cancer in Japan from 2000 to 2014 using data from the CONCORD-3 study. The key finding was that five-year net survival rates showed significant variations across cancer types and age groups. This highlights the need for targeted interventions to improve cancer outcomes among women in Japan.

Watanabe K, Di Carlo V, Sugiyama H et al. · Japanese journal of clinical oncology · (2026) · View on PubMed ↗

Apoptotic extracellular vesicles derived from MSCs exposed to hypoxic and inflammatory environments slow intervertebral disc degeneration by enhancing cell activity and regulating immunity microenvironment.​

This study investigated the therapeutic effects of apoptotic extracellular vesicles (ApoEVs) derived from mesenchymal stem cells (MSCs) in slowing intervertebral disc degeneration (IVDD). The key finding was that ApoEVs enhanced cell activity and regulated the immune microenvironment in the context of IVDD. This suggests that MSC-derived ApoEVs could be a promising therapeutic strategy for treating IVDD.

Zhang W, Ma X, Yin H et al. · Materials today. Bio · (2026) · View on PubMed ↗

Skeletal muscle metabolism in health and disease: Mechanisms, interventions, and clinical perspectives.​

This review provided an integrative synthesis of skeletal muscle metabolism, focusing on its role in energy homeostasis and the molecular mechanisms involved. The key finding was that disruptions in metabolic pathways can lead to conditions such as obesity and sarcopenia. This highlights the importance of understanding skeletal muscle metabolism for developing interventions against metabolic diseases.

Lin D, Zhang L, Huang C et al. · iScience · (2026) · View on PubMed ↗

Targeting tumor-associated macrophages-induced IGF1/PI3K/Zic1 axis triggers SHH medulloblastoma regression and chemosensitization.​

This study investigated the role of tumor-associated macrophages (TAMs) in medulloblastoma progression and chemoresistance using a genetically modified mouse model. The key finding was that targeting TAMs with specific inhibitors led to tumor regression and increased sensitivity to chemotherapy. This suggests that TAMs could be a viable therapeutic target in treating medulloblastoma.

Pang YC, Wang C, Qiu JF et al. · Neuro-oncology · (2026) · View on PubMed ↗

LRP8 is a functional receptor for yellow fever virus.​

This research identified LRP8 as a functional receptor for yellow fever virus (YFV), enhancing our understanding of YFV infection mechanisms. The key finding was that LRP8 expression increased YFV infection in cell lines and exacerbated pathology in mouse models. This discovery could inform vaccine development and therapeutic strategies against YFV.

Mei M, Yang Y, Zhang Z et al. · Nature microbiology · (2026) · View on PubMed ↗

Liquid biopsy for the diagnosis of EBV-positive Burkitt's lymphoma in endemic areas.​

This study evaluated the diagnostic accuracy of liquid biopsies for EBV-positive Burkitt's lymphoma in endemic areas of sub-Saharan Africa. The key finding was that blood-based biomarkers, including circulating tumor DNA, improved diagnostic turnaround time and accuracy compared to traditional methods. This suggests that liquid biopsy could enhance early diagnosis and treatment of Burkitt's lymphoma in resource-limited settings.

Chamba C, Christopher H, Josephat E et al. · Nature medicine · (2026) · View on PubMed ↗

Targeting WIP1 reprograms immunosuppressive tumor microenvironment to potentiate immunotherapy response in colorectal cancer.​

The study focused on the role of wild-type p53-induced phosphatase 1 (WIP1) in the immunosuppressive tumor microenvironment of colorectal cancer (CRC). It was found that inhibiting WIP1 significantly remodels the tumor immune microenvironment, enhancing anti-tumor immune cell infiltration. This suggests that targeting WIP1 could improve the efficacy of immunotherapy in CRC patients.

Chen L, Chen M, Yuan S et al. · Cell death and differentiation · (2026) · View on PubMed ↗

Type 2 diabetes mellitus.​

This article reviewed the epidemiology and clinical implications of type 2 diabetes mellitus (T2DM), particularly its increasing prevalence among younger populations. The key finding indicates that early-onset T2DM is associated with more severe complications and a higher risk factor burden compared to later-onset cases. Understanding these trends is crucial for developing targeted prevention and treatment strategies for T2DM.

Davies MJ, Lim S, Slater T et al. · Nature reviews. Disease primers · (2026) · View on PubMed ↗

Histone lactylation-driven feedback loop modulates pyrimidine metabolism to promote oral carcinogenesis.​

This study explored the role of histone lactylation in oral squamous cell carcinoma (OSCC) and its connection to metabolic reprogramming. It was found that lactate-dependent histone modification promotes OSCC initiation through metabolic alterations. This highlights the potential of targeting histone lactylation as a therapeutic strategy in OSCC.

Wang Y, Geng Y, Chen Y et al. · Cell death & disease · (2026) · View on PubMed ↗

Fibrinogen-Bmal1 signaling as a therapeutic target to limit aortic dissection by preserving VSMC contractility.​

This study evaluated the therapeutic potential of SHR-A1811, a novel HER2-targeting antibody-drug conjugate, in patients with advanced solid tumors. The trial demonstrated substantial antitumor activity in heavily treated HER2-expressing or mutated tumors. These results support further development of SHR-A1811 as a treatment option for this patient population.

Zhong X, Li D, Zhao Y et al. · Signal transduction and targeted therapy · (2026) · View on PubMed ↗

Prognostic Significance of MSI and EBV Positivity in PD-L1 Positive Gastric Cancer: A Systematic Review and Meta-Analysis.​

This systematic review and meta-analysis assessed the prognostic significance of microsatellite instability (MSI), PD-L1 expression, and Epstein-Barr virus (EBV) positivity in gastric cancer. The analysis revealed that these biomarkers are important for predicting overall survival and treatment outcomes in gastric cancer patients. This underscores the need for incorporating these biomarkers into clinical decision-making for gastric cancer management.

Petrelli F, Antista M, Ghidini A et al. · Cancer medicine · (2026) · View on PubMed ↗

Risk Assessment in Large B-Cell Lymphoma Using Metabolic Tumor Volume: Real-World Data from a Multicenter Cohort of Patients Undergoing CAR T-Cell Therapy.​

This study evaluated the use of metabolic tumor volume (MTV) as a predictive biomarker for outcomes in patients with large B-cell lymphoma undergoing CAR T-cell therapy. The results indicated that MTV-based risk scores could predict treatment responses more accurately than the traditional International Prognostic Index (IPI). This finding could improve patient stratification and treatment planning in CAR T-cell therapy.

Voltin CA, Flossdorf S, Kurch L et al. · Journal of nuclear medicine : official publication, Society of Nuclear Medicine · (2026) · View on PubMed ↗

Anifrolumab in systemic lupus erythematosus: real-world evidence from a Spanish multicentre cohort of 206 patients and literature review.​

This multicenter study assessed the real-world effectiveness and safety of anifrolumab in patients with systemic lupus erythematosus (SLE). The findings indicate that anifrolumab is effective in clinical practice, supporting its use beyond randomized clinical trials. This research contributes to the growing body of evidence for anifrolumab's role in managing SLE.

Calvo-Río V, Secada-Gómez C, Martín Gutiérrez A et al. · RMD open · (2026) · View on PubMed ↗

Hypoxia-related and immune phenotype-related fusion model for non-invasive prognostication of hepatocellular carcinoma treated by TACE: a multicentre study.​

This multicenter study developed a hypoxia-related and immune phenotype-related fusion model for prognostication in hepatocellular carcinoma (HCC) patients treated with transarterial chemoembolization (TACE). The model demonstrated improved predictive accuracy for survival outcomes compared to existing prognostic scores. This could enhance clinical decision-making and patient management in HCC.

Guo Y, Zhang G, Fu X et al. · Gut · (2026) · View on PubMed ↗

CAV1-DOT1L axis in TAM-derived EVs orchestrates VM and sensitises PDAC to combined VM and VEGF targeting.​

This study investigated the role of the CAV1-DOT1L axis in tumor-associated macrophage-derived extracellular vesicles in promoting vasculogenic mimicry (VM) in pancreatic ductal adenocarcinoma (PDAC). The findings elucidate the immune and epigenetic mechanisms regulating VM, suggesting potential therapeutic targets. This research could inform strategies to combat PDAC progression.

Liu Z, Zhang Y, Wu H et al. · Gut · (2026) · View on PubMed ↗

The efficacy and safety of cannabinoids for the treatment of mental disorders and substance use disorders: a systematic review and meta-analysis.​

This systematic review and meta-analysis evaluated the efficacy and safety of cannabinoids for treating mental disorders and substance use disorders. The analysis found that the evidence for cannabinoids as a primary treatment remains inconclusive. This highlights the need for further research to establish clear guidelines for cannabinoid use in these conditions.

Wilson J, Dobson O, Langcake A et al. · The lancet. Psychiatry · (2026) · View on PubMed ↗

A bispecific nanobody-drug conjugate targeting TROP2 and c-Met for low-concentration, single-dose treatment of pancreatic cancer.​

This study investigated the efficacy of a bispecific nanobody-drug conjugate (B6ADC) targeting TROP2 and c-Met in pancreatic cancer. B6ADC demonstrated potent cytotoxicity in vitro and superior tumor inhibition in vivo compared to single-target antibody-drug conjugates. This finding suggests that B6ADC could provide a more effective treatment option for pancreatic cancer patients with heterogeneous antigen expression.

Ning W, Liu H, Zeng H et al. · Cell reports. Medicine · (2026) · View on PubMed ↗

Psoriasis modulates inflammatory bowel disease risk and intestinal epithelium lipid metabolism via IL-1β-producing macrophages.​

This study examined the relationship between psoriasis and the risk of inflammatory bowel disease (IBD) through the role of IL-1β-producing macrophages. An inverse correlation was found between psoriasis severity and plasma apolipoprotein B48 levels, indicating impaired intestinal lipid handling. These findings suggest that psoriasis may influence IBD risk through alterations in lipid metabolism and immune responses.

Wu J, Liu S, Dan W et al. · Cell metabolism · (2026) · View on PubMed ↗

Preferences in Cyclin-Dependent Kinase 4/6 Inhibitors for Advanced Breast Cancer Among Medical Oncologists in Latin America.​

The preferences for cyclin-dependent kinase 4/6 inhibitors (CDK4/6i) among medical oncologists in Latin America were surveyed. Ribociclib emerged as the preferred agent, reflecting its perceived efficacy and availability. Understanding these preferences can inform treatment strategies and improve access to effective therapies for advanced breast cancer in the region.

Villarreal-Garza C, Meraz-Brenez A, Reyes Morales A et al. · JCO global oncology · (2026) · View on PubMed ↗

Efficacy and Safety of Remimazolam Tosylate versus Propofol for Sedation of Postoperative Mechanically Ventilated Patients in Intensive Care Units: a Multicenter, Randomized, Single-blind, Non-inferiority, Phase 3 trial.​

A multicenter, randomized, single-blind, phase 3 trial compared the efficacy and safety of remimazolam tosylate versus propofol for sedation in mechanically ventilated ICU patients. Remimazolam tosylate demonstrated non-inferiority to propofol in achieving target sedation levels. This study supports the use of remimazolam tosylate as a viable alternative for sedation in critical care settings.

Guan X, Liu N, Lin F et al. · Anesthesiology · (2026) · View on PubMed ↗

A sympathetic-eosinophil axis orchestrates psychological stress to exacerbate skin inflammation.​

The study investigated how a sympathetic-eosinophil axis mediates the exacerbation of skin inflammation due to psychological stress. Specific sympathetic neurons were shown to recruit eosinophils, worsening atopic dermatitis symptoms. This discovery highlights potential targets for therapeutic intervention in stress-related skin disorders.

Tian J, Cao Y, Li Y et al. · Science (New York, N.Y.) · (2026) · View on PubMed ↗

Overcoming T cell tolerance to tumor self-antigens through catch-bond engineering.​

The study investigated how catch-bond engineering can overcome T cell tolerance to tumor self-antigens. A modified T cell receptor targeting prostatic acid phosphatase (PAP) showed enhanced activity and tumor elimination in preclinical models. This approach could lead to more effective immunotherapies for cancer treatment.

Chen X, Mao Z, Kolawole EM et al. · Science (New York, N.Y.) · (2026) · View on PubMed ↗

Human DHX29 detects nonoptimal codon usage to regulate mRNA stability.​

This research focused on the role of the RNA-binding protein DHX29 in regulating mRNA stability through nonoptimal codon usage. DHX29 was identified as a critical factor in codon-dependent gene expression in human cells. Understanding this mechanism could provide insights into gene regulation and potential therapeutic targets.

Hia F, Wu Y, Yoshinaga M et al. · Science (New York, N.Y.) · (2026) · View on PubMed ↗

A CHKA-PML autophagy checkpoint enables tumors to evade glutamine starvation.​

This study investigated the role of choline kinase alpha (CHKA) in tumor cells under glutamine deprivation. The key finding was that CHKA enhances its noncanonical protein kinase activity, leading to the phosphorylation of promyelocytic leukemia (PML) at tyrosine 339, which promotes PML's cytoplasmic localization and alters its function. This research highlights a potential adaptive mechanism that tumors use to evade glutamine starvation, suggesting new therapeutic targets for cancer treatment.

Wang R, Cao L, He X et al. · Proceedings of the National Academy of Sciences of the United States of America · (2026) · View on PubMed ↗

ALG6 orchestrates coronavirus replication via the endoplasmic reticulum stress-autophagy axis.​

The study focused on the role of alpha-1,3-glucosyltransferase (ALG6) in the replication of coronaviruses, specifically transmissible gastroenteritis virus (TGEV). It was found that ALG6 knockout (KO) inhibits viral entry by downregulating the receptor aminopeptidase N (ANPEP) and triggers endoplasmic reticulum stress, suppressing viral replication. This research underscores the importance of host factors in coronavirus biology and may inform strategies for antiviral therapies.

Fu Y, Gao M, Fu Z et al. · Cell reports · (2026) · View on PubMed ↗

Ritlecitinib for Severe Alopecia Areata: A 24-Week, Multicentre, Real-World Study.​

This multicenter, real-world study evaluated the effectiveness and tolerability of ritlecitinib, a selective Janus kinase 3 inhibitor, in patients with severe alopecia areata over 24 weeks. The results indicated significant improvement in hair regrowth and tolerability among patients treated with ritlecitinib. This study contributes valuable real-world evidence supporting the use of ritlecitinib as a treatment option for severe alopecia areata.

Starace M, Rapparini L, Pampaloni F et al. · American journal of clinical dermatology · (2026) · View on PubMed ↗

Post hoc estimation of a quantitative restriction spectrum imaging biomarker for prostate cancer detection using conventional MRI.​

The study assessed the potential of restriction spectrum imaging (RSI) as a quantitative biomarker for prostate cancer detection using conventional MRI. It demonstrated that post hoc estimation of RSI metrics from standard diffusion-weighted imaging could serve as a viable surrogate for detecting clinically significant prostate cancer. This advancement may improve diagnostic accuracy in prostate cancer screening.

Do DD, Conlin CC, Bagrodia A et al. · Journal of applied clinical medical physics · (2026) · View on PubMed ↗

Long-term outcomes of eribulin‑based neoadjuvant chemotherapy for triple‑negative breast cancer patients stratified by homologous recombination deficiency status: results of the randomized JBCRG-22 study.​

The randomized JBCRG-22 study evaluated long-term outcomes of eribulin-based neoadjuvant chemotherapy in triple-negative breast cancer (TNBC) patients, stratified by homologous recombination deficiency (HRD) status. The findings indicated that HRD-positive patients had different responses to treatment compared to HRD-negative patients. This stratification could enhance personalized treatment approaches for TNBC.

Masuda N, Yasojima H, Bando H et al. · Breast cancer research and treatment · (2026) · View on PubMed ↗

Disruption of iron homeostasis by HERC2-FTL axis leads to chondrocyte loss and exacerbates osteoarthritis.​

This study investigated the role of the HERC2-FTL axis in iron homeostasis and its impact on chondrocyte loss in osteoarthritis (OA). It found that disruption of this axis contributes to ferroptosis, exacerbating OA progression. Understanding these mechanisms may lead to novel therapeutic targets for OA management.

Zhong Y, Duan J, Chen Z et al. · Apoptosis : an international journal on programmed cell death · (2026) · View on PubMed ↗

The therapeutic potential of Piezo1 channel-mediated ferroptosis and its inhibitor.​

The research explored the therapeutic potential of Piezo1 channel-mediated ferroptosis and its inhibition in various diseases. It demonstrated that Piezo1 activation leads to calcium influx and subsequent iron metabolism changes, promoting ferroptosis. This study suggests that targeting Piezo1 could provide new avenues for therapeutic interventions.

Nan K, Zhang L, Zhao Y et al. · Apoptosis : an international journal on programmed cell death · (2026) · View on PubMed ↗

Gsα deficiency in macrophages promotes tumor progression via the MAPK signaling pathway.​

This study examined the role of Gsα deficiency in tumor-associated macrophages (TAMs) and its effect on tumor progression via the MAPK signaling pathway. It was found that Gsα deficiency accelerates tumor growth and metastasis in mouse models. These findings suggest that targeting Gsα in TAMs could be a novel strategy for cancer immunotherapy.

Yan W, Yang J, Tan S et al. · Journal of molecular medicine (Berlin, Germany) · (2026) · View on PubMed ↗

Therapeutic Potential of Somatostatin and Its Analogues in Alzheimer's Disease: From Molecular Mechanisms to Preclinical Studies.​

The review discussed the potential of somatostatin and its analogues as multitarget therapies for Alzheimer's disease (AD). It highlighted their roles in amyloid-β metabolism, tau phosphorylation, and neuroinflammation. This research points to the need for further exploration of somatostatin-based therapies in AD treatment.

Liu K, Zhang XY, Wang YT et al. · Molecular neurobiology · (2026) · View on PubMed ↗

Proteomic analyses of human islets reveal potential markers of β-cell dysfunction during prediabetes.​

The study performed proteomic analyses of human islets to identify markers of β-cell dysfunction during prediabetes. It found significant changes in proteins related to glucose metabolism and lipid handling in individuals with impaired glucose tolerance. These insights could lead to early interventions for preventing type 2 diabetes.

Cefalo CMA, Mezza T, Quero G et al. · JCI insight · (2026) · View on PubMed ↗

Meat Consumption and Cognitive Health by APOE Genotype.​

This study investigated the association between meat consumption and cognitive health in individuals with different APOE genotypes, specifically ε3/ε4 and ε4/ε4. The key finding was that higher meat consumption was linked to cognitive health benefits in these APOE genotypes compared to others. This suggests that dietary recommendations for cognitive health may need to be personalized based on APOE genotype to better prevent Alzheimer’s disease.

Norgren J, Carballo-Casla A, Grande G et al. · JAMA network open · (2026) · View on PubMed ↗

Bireociclib Plus Fulvestrant in Advanced Breast Cancer After Endocrine Progression: The BRIGHT-2 Phase 3 Randomized Clinical Trial.​

The BRIGHT-2 trial evaluated the efficacy and safety of bireociclib combined with fulvestrant in patients with hormone receptor-positive, ERBB2-negative advanced breast cancer after endocrine therapy progression. The final analysis confirmed that this combination therapy significantly improved patient outcomes compared to placebo. These results support the use of bireociclib as a viable treatment option for this patient population.

Wang J, Zhang Q, Li H et al. · JAMA oncology · (2026) · View on PubMed ↗

Diagnostic Performance of Anti-Epstein-Barr Virus BNLF2b in Suspected Nasopharyngeal Carcinoma.​

This study assessed the diagnostic performance of the anti-EBV BNLF2b total antibody assay in patients suspected of nasopharyngeal carcinoma (NPC) and compared it with other EBV-related biomarkers. The findings indicated that the P85-Ab assay demonstrated superior diagnostic accuracy compared to traditional markers like VCA-IgA and EA-IgA. This advancement could enhance early detection and reduce misdiagnosis of NPC in clinical settings.

Li SC, Li FG, Wu SJ et al. · JAMA oncology · (2026) · View on PubMed ↗

Identification and Validation of miR-206-3p Targeting WT-1 Promotes Membranous Nephropathy Through a Comprehensive Bioinformatics and Machine Learning Algorithm.​

This study identified and validated the role of miR-206-3p in targeting WT-1, contributing to the pathogenesis of membranous nephropathy (MN) through bioinformatics and machine learning approaches. The research revealed that miR-206-3p is upregulated in MN and plays a critical role in the disease's molecular mechanisms. These findings could lead to the development of targeted therapies for MN.

Wang X, Zhou F, Fu C et al. · FASEB journal : official publication of the Federation of American Societies for Experimental Biology · (2026) · View on PubMed ↗

HTRA1+ macrophages induce T cells egress through CRIP1/NF-κB/CXCL12 to limit the effects of immunotherapy in triple-negative breast cancer.​

This research identified a subpopulation of HTRA1+ macrophages that promote T cell egress through the CRIP1/NF-κB/CXCL12 pathway, impacting immunotherapy responses in triple-negative breast cancer (TNBC). The study found that this macrophage subset correlates with clinical outcomes and T cell expansion during immunotherapy. Understanding these mechanisms may enhance the effectiveness of immunotherapy in TNBC patients.

Weng J, Xu W, Wang F et al. · Cancer immunology research · (2026) · View on PubMed ↗

Stage-specific transcriptomics of a leader cell reveals cell machineries driving collective invasion.​

This study presented a stage-specific transcriptomic analysis of the distal tip cell (DTC) in Caenorhabditis elegans, which plays a crucial role in collective cell invasion. The research identified molecular signatures that differentiate invasive larval-stage DTCs from noninvasive adult-stage DTCs. These insights could inform our understanding of the mechanisms underlying collective invasion in various biological contexts.

Agarwal P, Maimon Zielonka I, Gingold H et al. · The Journal of cell biology · (2026) · View on PubMed ↗

Transcriptomic Insights Into Alzheimer's Disease: Differentially Expressed Genes and Cholesterol Metabolism.​

This study explored the relationship between differentially expressed genes and cholesterol metabolism in Alzheimer's disease (AD) using advanced machine learning techniques. The findings highlighted significant alterations in cholesterol metabolism pathways associated with AD. This research underscores the potential for targeting cholesterol metabolism in developing therapeutic strategies for AD.

Sun R, Wang X, Wang Z et al. · CNS neuroscience & therapeutics · (2026) · View on PubMed ↗

Use of ctDNA in Older Women with ER+ Breast Cancer to Facilitate Surgical De-escalation: A Prospective, Hybrid-Decentralized Trial with Correlative Studies.​

This prospective trial investigated the use of circulating tumor DNA (ctDNA) to guide surgical de-escalation in older women with estrogen receptor-positive breast cancer. The results indicated that ctDNA levels were associated with tumor progression, suggesting its potential as a biomarker for treatment decisions. This approach could optimize therapy for older patients with competing comorbidities.

Carleton N, Chang AC, Chen F et al. · Clinical cancer research : an official journal of the American Association for Cancer Research · (2026) · View on PubMed ↗

Albumin-Bound STING Agonist Reprograms HSPCs to Antitumor Neutrophils Enhancing CD8+ T Cell Immunity.​

This study demonstrated that an albumin-bound STING agonist (Nano ZSA-51D) can reprogram hematopoietic stem and progenitor cells (HSPCs) into antitumor neutrophils, enhancing CD8+ T cell immunity. The findings suggest that this reprogramming strategy could sensitize tumors to α-PD1 immunotherapy. This approach represents a novel therapeutic avenue for improving cancer immunotherapy outcomes.

Tao J, Zhao HY, Li C et al. · Advanced science (Weinheim, Baden-Wurttemberg, Germany) · (2026) · View on PubMed ↗

ECM1 produced by hepatic stellate cells serves as gate keeper of liver homeostasis in hepatic fibrosis.​

This research examined the role of ECM1 produced by hepatic stellate cells in maintaining liver homeostasis during hepatic fibrosis. The study found that ECM1 acts as a gatekeeper, influencing the activation and function of hepatic stellate cells in different fibrosis models. These insights could lead to new therapeutic strategies aimed at preserving liver function in fibrotic diseases.

Yang A, Yan X, Wang Y et al. · Hepatology (Baltimore, Md.) · (2026) · View on PubMed ↗

Onasemnogene Abeparvovec in Type I Spinal Muscular Atrophy: 24-Month Follow-Up From the Italian Registry.​

This observational study followed patients with spinal muscular atrophy type I treated with onasemnogene abeparvovec (OA) over 24 months to assess real-world clinical outcomes. The findings revealed variability in treatment responses compared to clinical trials, emphasizing the need for personalized treatment approaches. This long-term data is crucial for understanding the effectiveness of gene therapy in SMA.

Pane M, Coratti G, Cutrì C et al. · Annals of clinical and translational neurology · (2026) · View on PubMed ↗

A Rare RIPK3 Variant Enhances Necroptosis and Promotes Inflammation in a Still's Disease-like Autoinflammatory Syndrome.​

This study identified a rare variant in the RIPK3 gene that enhances necroptosis and promotes inflammation in a family with a Still's disease-like autoinflammatory syndrome. Functional analyses demonstrated that the RIPK3 p.Q134K variant significantly affects kinase activity and inflammatory signaling pathways. These findings provide insights into the genetic basis of autoinflammatory diseases and potential therapeutic targets.

Chen L, Dai Q, Xiao Y et al. · Arthritis & rheumatology (Hoboken, N.J.) · (2026) · View on PubMed ↗

Early-Life Melatonin Supplementation Reduces the Long-Term Behavioral, Morphological, and Molecular Alterations in a Rat Model of Autism Spectrum Disorder.​

This study investigated the effects of early-life melatonin supplementation on behavioral, morphological, and molecular alterations in a rat model of autism spectrum disorder (ASD). The results indicated that melatonin administration during early development mitigated long-term ASD-related changes. This suggests that melatonin could be a potential therapeutic agent for addressing ASD symptoms.

Hernández-Sierra LJ, Salgado-Delgado RC, Ibáñez-Sandoval O et al. · Journal of pineal research · (2026) · View on PubMed ↗

Phospholipid Glutathione Peroxidase Overexpression Mitigates Cancer Cachexia by Protecting Muscle Mass and Lowering Inflammation.​

This research demonstrated that overexpression of phospholipid glutathione peroxidase can mitigate cancer cachexia by protecting muscle mass and reducing inflammation. The study found that this intervention counteracts the oxidative stress associated with cancer cachexia. These findings highlight a potential therapeutic target for improving muscle health in cancer patients.

Duggan E, Fuqua JD, Hagy B et al. · Journal of cachexia, sarcopenia and muscle · (2026) · View on PubMed ↗

Effects of Diactive-1-Supported Progressive Resistance Training on Body Composition in Youth With Type 1 Diabetes.​

This study explored the effects of Diactive-1-supported progressive resistance training on body composition in youth with type 1 diabetes. The findings indicated that this intervention positively influenced body composition parameters, including fat and lean mass. This suggests that resistance training could be an effective strategy for managing body composition in children and adolescents with type 1 diabetes.

Muñoz-Pardeza J, López-Gil JF, Hormazábal-Aguayo I et al. · Journal of cachexia, sarcopenia and muscle · (2026) · View on PubMed ↗

Cardiovascular Health​

Prognostic Impact of Elevated Pulmonary Vascular Resistance in Group 2 Pulmonary Hypertension: Insights From a Japanese Multicenter Registry.​

This study analyzed the prognostic impact of elevated pulmonary vascular resistance (PVR) in patients with Group 2 pulmonary hypertension using data from two Japanese multicenter registries. The key finding was that higher PVR was associated with worse clinical outcomes, including hospitalization and mortality. This underscores the importance of monitoring PVR in managing Group 2 pulmonary hypertension and guiding treatment decisions.

Satoh T, Sugimura K, Fukumoto Y et al. · Journal of the American Heart Association · (2026) · View on PubMed ↗

Stroke Risk After Bioprosthetic Aortic Valve Replacement in Aortic Stenosis: Systematic Review and Meta-Analysis.​

This systematic review and meta-analysis assessed the risk of stroke following bioprosthetic aortic valve replacement (AVR) in adults with severe aortic stenosis. The key finding was that the incidence of ischemic stroke varied significantly between transcatheter AVR, surgical AVR, and valve-in-valve replacement procedures. This information is crucial for clinicians in managing stroke risk and improving patient prognostication after AVR.

Bou Dargham T, Hassani S, Mac Grory BC et al. · Stroke · (2026) · View on PubMed ↗

Inhibiting RhoA Activation Via GDP-State Stabilization to Relieve Heart Failure.​

This study explored the inhibition of RhoA activation as a potential therapeutic strategy for relieving heart failure (HF) by targeting myocardial remodeling. The key finding was that stabilizing the GDP-bound state of RhoA could effectively reduce pathological hypertrophy and fibrosis in heart tissue. This suggests that RhoA inhibitors may represent a novel approach to treating heart failure.

Xue M, Liang Y, Yuan Z et al. · Circulation research · (2026) · View on PubMed ↗

Metabolic Disorders​

FGF21-Mediated Upregulation of SIRT1 Delays Intervertebral Disc Degeneration by Promoting PINK1/Parkin Dependent Mitophagy Through Deacetylation of FOXO3.​

The study investigated the role of FGF21 in delaying intervertebral disc degeneration (IDD) by promoting mitophagy through SIRT1 upregulation. The key finding was that FGF21 expression was downregulated in degenerated intervertebral discs, correlating with increased senescence markers. This suggests that FGF21 could be a potential therapeutic target for preventing or treating IDD.

Wu ZL, Ran R, Xie QQ et al. · Aging cell · (2026) · View on PubMed ↗

Neurodegenerative Diseases​

Tavapadon as Adjunctive Treatment for Parkinson Disease: The TEMPO-3 Randomized Clinical Trial.​

This clinical trial evaluated the efficacy and safety of tavapadon, a selective D1/D5 agonist, as adjunctive treatment for Parkinson's disease (PD) patients experiencing motor fluctuations while on levodopa. The key finding was that tavapadon improved motor control with a favorable safety profile compared to traditional D2/D3 agonists. This indicates that tavapadon may offer a new therapeutic option for managing motor symptoms in PD.

Fernandez HH, Isaacson SH, Hauser RA et al. · JAMA neurology · (2026) · View on PubMed ↗

Host-derived nitrate fuels indole production by Escherichia coli to drive chronic kidney disease progression.​

The study explored how host-derived nitrate influences indole production by Escherichia coli, contributing to chronic kidney disease (CKD) progression. Elevated nitrate levels were found to promote E. coli growth, which in turn increased indole production linked to CKD. These findings suggest a potential microbial target for therapeutic strategies in CKD management.

Lee JY, Mahan SP, Parente de Carvalho T et al. · Science (New York, N.Y.) · (2026) · View on PubMed ↗

Astrocytes at the crossroads of obstructive sleep apnea and Alzheimer's disease: from oxygen sensing to neurodegeneration.​

The review examined the role of astrocytes in the relationship between obstructive sleep apnea (OSA) and Alzheimer's disease (AD). It highlighted that OSA may contribute to AD progression through mechanisms involving astrocytic dysfunction and neuroinflammation. Understanding this link could lead to new therapeutic approaches for preventing cognitive decline in patients with OSA.

Cabot J, Soriano JB, Alonso-Fernández A et al. · Sleep & breathing = Schlaf & Atmung · (2026) · View on PubMed ↗

Regulation of YAP activity by nuclear G-actin binding.​

This study investigated the regulation of YAP activity by nuclear G-actin binding, highlighting its role in the Hippo pathway and cellular processes such as differentiation and cancer metastasis. The findings revealed that G-actin binding influences YAP's transcriptional activity and cellular localization. Understanding this regulation could provide insights into the mechanisms of tissue growth and cancer progression.

Wang H, Jayawardana IM, Fleisch JM et al. · Nucleic acids research · (2026) · View on PubMed ↗

Gene Therapy and Genetic Research​

Embedded CRISPRi Enhances Gene-Silencing Efficiency in Drosophila.​

This research introduced embedded CRISPR interference (emCRISPRi) as a novel gene-silencing platform in Drosophila melanogaster. The key finding was that emCRISPRi significantly enhanced gene-silencing efficiency by integrating transcriptional repression domains into dCas9, allowing robust repression of coding genes. This advancement could facilitate more effective genetic studies and applications in Drosophila research.

Fu P, Zhang X, Zhou Y et al. · Advanced science (Weinheim, Baden-Wurttemberg, Germany) · (2026) · View on PubMed ↗

Transplantation of encapsulated mitochondria alleviates dysfunction in mitochondrial and Parkinson's disease models.​

The research focused on mitochondrial transplantation using encapsulated mitochondria to alleviate dysfunction in mitochondrial and Parkinson's disease models. The approach successfully delivered mitochondria into cells and tissues of mice and monkeys, rescuing bioenergetic defects in patient-derived cells. This technique holds promise for treating mitochondrial diseases by improving mitochondrial function in affected tissues.

Du S, Long Q, Zhou Y et al. · Cell · (2026) · View on PubMed ↗

Commensal-driven serotonin production modulates in vivo delivery of synthetic and viral vectors.​

The study examined how commensal-driven serotonin production modulates the in vivo delivery of synthetic and viral vectors. Disruption of commensal-host interactions improved drug and gene delivery efficiency. This finding suggests that manipulating gut microbiota could enhance the effectiveness of therapeutic delivery systems.

Wang Q, Chen Z, Zhang G et al. · Science (New York, N.Y.) · (2026) · View on PubMed ↗

Immunology and Inflammation​

CD177⁺ neutrophil-platelet aggregates contribute to thromboinflammation via NETs in necrotizing enterocolitis.​

The study investigated the role of CD177⁺ neutrophil-platelet aggregates in thromboinflammation associated with necrotizing enterocolitis (NEC) in premature infants. The findings demonstrated that these aggregates contribute to immunothrombosis and local intestinal inflammation in NEC. This research could lead to new therapeutic approaches targeting thromboinflammation in NEC.

Lan C, Tian B, Shi Y et al. · Nature communications · (2026) · View on PubMed ↗

A neuroimmune circuit links stress to skin inflammation.​

This research identified a neuroimmune circuit linking stress to skin inflammation, specifically in the context of atopic dermatitis. Sympathetic neurons were found to activate eosinophils during stress, exacerbating skin inflammation. Understanding this connection could lead to new therapeutic strategies for managing stress-related skin conditions.

Gaudenzio N, Basso L · Science (New York, N.Y.) · (2026) · View on PubMed ↗

Microbiome and Gut Health​

How gut microbiota contribute to neuropsychiatric disorders: evidence from neuroimaging studies.​

This review examined the contribution of gut microbiota to neuropsychiatric disorders, utilizing neuroimaging studies to explore the microbiota-gut-brain axis. The key finding was that alterations in gut microbiota are associated with various CNS diseases, including neurodevelopmental and psychiatric conditions. This underscores the potential for microbiota-targeted therapies in treating neuropsychiatric disorders.

Jia C, Zhu W, Yuan Y et al. · Frontiers in microbiology · (2026) · View on PubMed ↗

Gut microbe-derived N-acyl serinol lipids shape host postprandial metabolic homeostasis.​

This research investigated the impact of gut microbe-derived N-acyl serinol lipids on postprandial metabolic homeostasis. The study demonstrated that these lipids play a significant role in mediating metabolic responses to food intake. Understanding these interactions could lead to microbiome-inspired therapies for metabolic diseases.

Dutta S, Mahen KK, Massey WJ et al. · Proceedings of the National Academy of Sciences of the United States of America · (2026) · View on PubMed ↗

Clinical Guidelines and Recommendations​

Joint TOS/OMA/OAC expert guidance statement on the pharmacological management of United States adults with overweight or obesity using the GRADE approach.​

This expert guidance statement provided updated recommendations for the pharmacological management of overweight or obesity in U.S. adults, emphasizing the need for evidence-based treatment approaches. The key finding was that FDA-approved obesity medications can significantly improve health outcomes, yet access remains limited due to various barriers. This highlights the urgent need for improved access to obesity treatments to address the growing obesity epidemic.

Alexander L, Purnell JQ, Burridge K et al. · Obesity pillars · (2026) · View on PubMed ↗

Clinical practice guideline for long COVID prevention and treatment.​

This clinical practice guideline addresses the prevention and treatment of long COVID in adults. It provides evidence-based recommendations for healthcare professionals involved in the management of long COVID. The guideline aims to standardize care and improve outcomes for patients suffering from this condition.

Cao B, Soriano JB, Wang Q et al. · The European respiratory journal · (2026) · View on PubMed ↗

Effectiveness of Al-Assisted Patient Health Education Using Voice Cloning and ChatGPT: Prospective Randomized Controlled Trial.​

The effectiveness of AI-assisted patient education using voice cloning and ChatGPT was evaluated in a prospective randomized controlled trial. Results indicated that AI-driven education improved patient engagement and knowledge acquisition compared to traditional methods. This approach could enhance personalized health education and treatment adherence in clinical settings.

Sun Y, Xu S, Jin H et al. · Journal of medical Internet research · (2026) · View on PubMed ↗

Machine Learning-Based Sleep Electroencephalographic Brain Age Index and Dementia Risk: An Individual Participant Data Meta-Analysis.​

The randomized clinical trial compared transradial access (TRA) and transfemoral access (TFA) for cerebral angiography. The results indicated that TRA is a safe and effective alternative to TFA for this procedure. This study may influence clinical practice by promoting the adoption of TRA in neurointerventional procedures.

Sun H, Milton S, Fang Y et al. · JAMA network open · (2026) · View on PubMed ↗

Transradial vs Transfemoral Access for Cerebral Angiography: A Randomized Noninferiority Clinical Trial.​

This study aimed to provide expert recommendations on switching to cladribine tablets for relapsing multiple sclerosis (RMS) patients previously treated with high-efficacy disease-modifying therapies. The experts highlighted the need for evidence-based guidelines to optimize treatment sequencing and improve patient outcomes. This work addresses a significant gap in the management of RMS.

Ni W, Yang H, Su J et al. · JAMA network open · (2026) · View on PubMed ↗

International Dermoscopy Society consensus recommendations for the management of lentigo maligna.​

This consensus statement from the International Dermoscopy Society provides recommendations for managing lentigo maligna, a melanoma in situ that occurs on sun-damaged skin. The guidelines address the challenges of diagnosing and treating lentigo maligna, particularly in elderly patients. This work aims to improve clinical practice by offering evidence-based strategies for managing this condition.

Forsea AM, Pampena R, Akay BN et al. · Journal of the European Academy of Dermatology and Venereology : JEADV · (2026) · View on PubMed ↗

Nutrition and Dietary Interventions​

Adherence to the EAT-Lancet Diet and Risk of Sepsis: A Prospective Cohort Study from the UK Biobank.​

This prospective cohort study examined the association between adherence to the EAT-Lancet diet and the risk of sepsis among participants in the UK Biobank. The study found that higher adherence to this diet was linked to a significantly reduced risk of sepsis (HR 0.85). These findings suggest that dietary interventions may play a role in sepsis prevention.

Nan W, Huang Q, He B et al. · NPJ science of food · (2026) · View on PubMed ↗

Velocity Loss During Resistance Training: Implications for Concurrent Training Adaptations.​

This study explored the impact of different velocity loss thresholds during resistance training on adaptations to concurrent training in moderately trained men. Results indicated that varying velocity loss influenced strength, endurance, and hypertrophic outcomes. These findings provide insights into optimizing resistance training protocols for improved athletic performance.

Tundidor-Duque RM, Loturco I, Paéz-Maldondado JA et al. · Scandinavian journal of medicine & science in sports · (2026) · View on PubMed ↗

Molecular Biology and Biochemistry​

Cryo-EM structure of TRPM1 reveals a non-canonical architecture with an inverted transmembrane domain.​

The research investigated the structure of the TRPM1 protein, which is essential for vision in dim light, using cryogenic electron microscopy (cryo-EM). The study revealed a non-canonical architecture of TRPM1, challenging previous assumptions about its function as an ion channel. This structural insight could inform future studies on TRPM1-related vision disorders.

Fabrizio M, Brewer M, Bogdanović N et al. · Nature communications · (2026) · View on PubMed ↗

Mitoxyperilysis: fasting-induced cell death in immunometabolism and disease.​

This article discusses mitoxyperilysis, a newly identified mode of cell death linked to mitochondrial rupture during immune responses combined with fasting. The study suggests that this lytic cell death mechanism may have therapeutic implications for conditions like sepsis and cancer. Understanding mitoxyperilysis could lead to novel treatment strategies targeting immune metabolism.

Al-Zidan R, Gautam M, Man SM · Trends in biochemical sciences · (2026) · View on PubMed ↗

Resetting of a tandem microRNA156 enables vegetative perennial growth in rice.​

This research focused on the genetic mechanisms underlying perennial growth in rice, specifically through the Endless Branches and Tillers (EBT1) locus. The wild rice allele EBT1W1943 was found to promote vegetative propagation by resetting microRNA156 expression. These insights could inform breeding strategies for developing perennial rice varieties.

Dai B, Lv D, Chen E et al. · Science (New York, N.Y.) · (2026) · View on PubMed ↗

Unstructured transcription factor interactions enable emergent specificity.​

The study explored how unstructured transcription factor interactions contribute to emergent specificity in gene regulation. Using proximity-assisted photoactivation, the research revealed that intrinsically disordered regions enhance transcription factor interactions with chromatin. These findings could reshape our understanding of transcriptional regulation and its implications for gene expression.

Abidi AA, Cattoglio C, Tang NN et al. · Science (New York, N.Y.) · (2026) · View on PubMed ↗

Psychiatric Disorders​

Postural Orthostatic Tachycardia Syndrome, Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Long COVID as Neuroimmune Disorders.​

This article discussed the overlapping pathophysiology of Postural Orthostatic Tachycardia Syndrome (POTS), myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), and Long COVID as neuroimmune disorders. The key finding was that these conditions share common mechanisms such as autonomic dysfunction and immune dysregulation. This suggests that understanding their shared pathophysiology could lead to more effective treatments.

Blitshteyn S, Doherty TA, Steinman L · ImmunoTargets and therapy · (2026) · View on PubMed ↗

Hypothalamic clock governs circadian pain.​

This research identified a hypothalamic clock that governs circadian rhythms in chronic pain. Daily oscillations in nociceptive thresholds were linked to neuronal activity in the suprachiasmatic nucleus. Understanding these mechanisms could lead to novel approaches for managing pain based on circadian biology.

Wei HR, Lou Q, Li LX et al. · Science (New York, N.Y.) · (2026) · View on PubMed ↗

From chronic pain to depression: Neurogenesis-driven microglial remodeling in the hippocampal dentate gyrus.​

This research examined the transition from chronic pain to depression, focusing on neurogenesis-driven microglial remodeling in the hippocampus. Biphasic changes in hippocampal volume were observed, with early pain stages showing increased volume and cognitive improvements, followed by declines associated with depression. These insights could inform interventions aimed at preventing affective disorders in chronic pain patients.

Ding M, Xiang S, Zhang Y et al. · Science (New York, N.Y.) · (2026) · View on PubMed ↗

Public Health and Epidemiology​

A predictive atlas of disease onset from retinal fundus photographs: a modelling study using data from population-based cohorts.​

This modeling study aimed to predict disease onset using retinal fundus photographs across various human diseases. The findings suggest that retinal images can serve as a non-invasive tool for early disease risk assessment. This approach could enhance preventive healthcare strategies by identifying high-risk individuals.

Buergel T, Loock L, Steinfeldt J et al. · The Lancet. Digital health · (2026) · View on PubMed ↗

Epidemiology, ventilation, and outcomes of acute respiratory failure in immunocompromised patients from 103 intensive care units in 26 countries: a retrospective observational study.​

This retrospective observational study examined acute respiratory failure (ARF) in immunocompromised patients across 103 intensive care units in 26 countries. The study identified predictors of mortality and intubation in this vulnerable population. These insights could inform clinical management and improve outcomes for immunocompromised patients with ARF.

Azoulay E, McEvoy C, Castro P et al. · The Lancet. Respiratory medicine · (2026) · View on PubMed ↗

Quantifying immune dysregulation in pneumonia and sepsis with a parsimonious machine-learning model: a multicohort analysis across care settings and reanalysis of a hydrocortisone randomised controlled trial.​

This multicohort analysis aimed to quantify immune dysregulation in pneumonia and sepsis using a machine-learning model. The study found that quantifying immune dysregulation could enhance prognostication and treatment evaluation in sepsis. This approach may help identify patients most likely to benefit from immunomodulatory therapies.

Michels EHA, Dequin PF, Butler JM et al. · The Lancet. Respiratory medicine · (2026) · View on PubMed ↗

Integration of Epidemiology and Network Toxicology Revealed the Arrhythmogenic Potential of Neonicotinoid Insecticides.​

This study integrated epidemiology and network toxicology to assess the arrhythmogenic potential of neonicotinoid insecticides in humans. Higher concentrations of neonicotinoids were found in arrhythmia patients compared to healthy controls, indicating a potential link between exposure and disease. These findings raise concerns about the cardiac safety of neonicotinoids and their role in public health.

Ge Y, Xiao Q, Fu B et al. · Environmental science & technology · (2026) · View on PubMed ↗

The relationship between sarcopenia and all-cause and cardiovascular mortality risk among middle-aged and older adults across stages 0-3 of cardiovascular-kidney-metabolic syndrome: evidence from NHANES and CHARLS.​

The relationship between sarcopenia and mortality risk among middle-aged and older adults across stages 0-3 of cardiovascular-kidney-metabolic syndrome was investigated. Sarcopenia was associated with increased all-cause and cardiovascular mortality risk, highlighting its significance as a health concern. This study underscores the need for early identification and management of sarcopenia in at-risk populations.

Chen Y, Liu Y, Liu S et al. · Cardiorenal medicine · (2026) · View on PubMed ↗

Phase separation of Rht8-derived RNHL1 integrates ethylene and gibberellin signaling to regulate wheat internode elongation.​

The research explored the molecular mechanisms by which RNHL1, derived from the Rht8 gene in wheat, regulates internode elongation through phase separation. It was discovered that RNHL1 forms nuclear biomolecular condensates and interacts with the ethylene signaling transcription factor TaEIL1 to modulate transcriptional activity. This study provides insights into plant growth regulation and could inform breeding strategies for improved wheat varieties.

Dong C, Cheng X, Yuan M et al. · The Plant cell · (2026) · View on PubMed ↗

MASLD as a systemic metabolic disease: expanding the scope of cardiovascular-kidney-metabolic (CKM) syndrome.​

This article discussed metabolic dysfunction-associated steatotic liver disease (MASLD) as a systemic metabolic disease impacting cardiovascular and renal health. It emphasized that MASLD is often underdiagnosed in cardiology and nephrology, despite its significant systemic effects. Recognizing MASLD's role in the cardiovascular-kidney-metabolic (CKM) syndrome could enhance patient management and outcomes.

Zhou XD, Fan QY, Targher G et al. · Science China. Life sciences · (2026) · View on PubMed ↗

Managing Bone Fragility in Older Adults with Diabetes: Pathophysiology, Assessment, and Therapeutic Considerations.​

This review addressed the increased risk of bone fragility in older adults with diabetes, focusing on the distinct pathophysiological mechanisms in type 1 and type 2 diabetes. It highlighted that type 1 diabetes is associated with reduced bone mineral density, while type 2 diabetes may present with normal or high bone density but poor bone quality. Understanding these differences is crucial for developing targeted strategies to prevent fractures in this population.

Bahat G, Erdogan T, Ozturk S et al. · Drugs & aging · (2026) · View on PubMed ↗

Interplay of oxidative stress and neuroinflammation in alzheimer's: insights into age-driven pathogenesis.​

The study investigated the interplay between oxidative stress and neuroinflammation in the pathogenesis of Alzheimer's disease (AD). It found that mitochondrial dysfunction and chronic inflammasome activation contribute to neuroinflammation and cognitive decline in aging. These insights could inform new therapeutic strategies targeting oxidative stress and inflammation in AD.

Firdous SM, Chakrabortty S, Undale VR et al. · Inflammopharmacology · (2026) · View on PubMed ↗

Women with epilepsy: Evidence-based counseling across the lifespan.​

This review focused on the unique challenges faced by women with epilepsy throughout their lifespan, emphasizing the need for comprehensive clinical management beyond seizure control. It highlighted significant gaps in integrating sex-specific aspects of epilepsy into routine care. Addressing these gaps could improve the quality of care and health outcomes for women with epilepsy.

Tettenborn B, Ramantani G, Flügel D et al. · Epilepsia · (2026) · View on PubMed ↗

The relationship between dietary patterns and neuroinflammation.​

This review examined the impact of dietary patterns on neuroinflammation, highlighting their role in modulating immune responses and the central nervous system's vulnerability to inflammation. The study emphasized that specific dietary choices could influence the risk of neurological and psychiatric disorders. This underscores the importance of nutrition in managing neuroinflammatory conditions.

Medoro A, Scapagnini G, Hu FB et al. · Critical reviews in food science and nutrition · (2026) · View on PubMed ↗

Other​

Glucagon-like peptide-1 receptor agonists for major cardiovascular and kidney outcomes in type 1 diabetes.​

This study assessed the long-term cardiovascular and kidney outcomes of glucagon-like peptide-1 receptor agonists (GLP-1RAs) in patients with type 1 diabetes using national electronic health records. The key finding was that GLP-1RA initiation was associated with lower risks of major adverse cardiovascular events and end-stage kidney disease. This indicates that GLP-1RAs may provide significant long-term benefits for cardiovascular and kidney health in type 1 diabetes patients.

View on PubMed ↗

Extrachromosomal DNA in urothelial carcinoma: mechanisms and clinical applications.​

This study investigated the role of extrachromosomal DNA (ecDNA) in urothelial carcinoma. The key finding was that ecDNA amplifies oncogenes and contributes to genomic instability and aggressive disease. This research highlights the potential of ecDNA as a biomarker for non-invasive detection and therapeutic targeting in urothelial carcinoma.

View on PubMed ↗

Association between COVID-19 vaccination and sudden death in apparently healthy younger individuals: A population-based case-control study.​

This population-based case-control study examined the association between COVID-19 vaccination and sudden death in healthy individuals aged 12-50 years in Ontario, Canada. The study found no significant evidence linking COVID-19 vaccination to an increased risk of sudden death in this demographic. These findings may help alleviate concerns regarding vaccine safety in younger populations.

View on PubMed ↗

Unveiling the multifaceted roles of BCL3: biological functions and disease implications.​

This study utilized proteomic analyses of human pancreatic islets to identify potential markers of beta-cell dysfunction in prediabetes. It revealed that individuals with impaired glucose tolerance exhibited reductions in proteins involved in glycolysis and lipid metabolism. These findings could lead to early diagnostic markers for predicting the onset of type 2 diabetes.

View on PubMed ↗

Generated automatically on March 21, 2026 from PubMed's trending articles. Summaries are AI-generated; always consult the original publication for clinical or research decisions.

Automated digest · 99 articles · 15 research areas · March 21, 2026

Overview​

Across this week’s set, a clear through-line is the push toward scalable, mechanism-informed care: AI-enabled clinical workflows (e.g., stroke CDSS and automated AI-driven patient education) and noninvasive or “liquid/quantitative” biomarkers (ctDNA, liquid biopsy for EBV-positive Burkitt’s lymphoma, PET metabolic tumor volume, retinal imaging atlases, and post hoc MRI biomarker estimation) aim to standardize decisions, shorten time-to-action, and improve risk stratification.

On the biology side, many studies converge on immune regulation as a therapeutic lever—both in cancer and inflammatory disease. Tumor-associated macrophage programs (multiple axes including IGF1/PI3K/Zic1–SHH, CAV1–DOT1L–driven vasculogenic mimicry, HTRA1+ macrophage immune evasion, and Gsα–MAPK signaling) repeatedly emerge as actionable vulnerabilities, while colorectal cancer work highlights how targeting immunosuppressive pathways (e.g., WIP1) can remodel the tumor microenvironment toward anti-tumor immunity. Outside oncology, neuroimmune and immunothrombotic mechanisms (stress–sympathetic–eosinophil circuits in atopic dermatitis, immunothrombosis in NEC, and neuroimmune frameworks linking POTS/ME-CFS/Long COVID) underscore how shared inflammatory pathways may unify seemingly distinct syndromes.

Finally, several papers emphasize metabolism and systemic physiology as upstream drivers—ranging from lactate-driven epigenetic regulation in oral cancer, nutrient stress adaptation in tumors, and ferroptosis-related iron/ion-channel pathways, to microbiome–host metabolic signaling (including microbiota-derived serotonin affecting hepatic vector delivery and diet–microbe axes influencing sepsis risk). Together, these studies reinforce a broad theme: integrating quantitative diagnostics, immune biology, and metabolic control may yield more precise and durable interventions across diverse diseases.

AI & Digital Clinical Decision Support​

Effect of a clinical decision support system on stroke care quality and outcomes in patients with acute ischaemic stroke (GOLDEN BRIDGE II): cluster randomised clinical trial.​

This multicentre cluster randomised clinical trial studied whether a stroke clinical decision support system (CDSS) using artificial intelligence-assisted imaging analysis, stroke-cause classification, and evidence-based treatment recommendations improves care quality and outcomes in 21,603 patients with acute ischaemic stroke admitted within 7 days across 77 hospitals in China. Hospitals receiving the CDSS support achieved better stroke care quality and improved clinical outcomes compared with control hospitals. The findings support deploying AI-enabled CDSS workflows to standardise acute stroke management at scale and potentially improve patient prognosis.

Zhang X, Ding L, Jing J et al. · BMJ (Clinical research ed.) · (2026) · View on PubMed ↗

Effectiveness of Al-Assisted Patient Health Education Using Voice Cloning and ChatGPT: Prospective Randomized Controlled Trial.​

The study evaluated AI-assisted patient health education using voice cloning and ChatGPT in a prospective randomized controlled trial. It compared different voice-cloning strategies and assessed the reliability/effectiveness of automated AI evaluation tools for improving patient education outcomes. If effective, this would support scalable, personalized digital health education workflows that can be implemented with automated assessment.

Sun Y, Xu S, Jin H et al. · Journal of medical Internet research · (2026) · View on PubMed ↗

Clinical Trials & Therapeutics in Neurology​

Tavapadon as Adjunctive Treatment for Parkinson Disease: The TEMPO-3 Randomized Clinical Trial.​

This randomised clinical trial evaluated tavapadon, an oral once-daily selective D1/D5 agonist, as adjunctive therapy to levodopa in adults with Parkinson disease experiencing motor fluctuations. Tavapadon improved motor control while demonstrating an acceptable safety and tolerability profile compared with placebo/standard adjunctive management (as per the trial design). The results support D1/D5 agonism as a potential approach to reduce motor fluctuations with potentially fewer D2/D3-related adverse events.

Fernandez HH, Isaacson SH, Hauser RA et al. · JAMA neurology · (2026) · View on PubMed ↗

Ritlecitinib for Severe Alopecia Areata: A 24-Week, Multicentre, Real-World Study.​

This real-world retrospective multicenter study evaluated ritlecitinib 50 mg/day over 24 weeks in patients aged ≥12 years with severe alopecia areata (SALT ≥50) in Italy. The key finding was the observed effectiveness and tolerability of ritlecitinib in routine clinical practice after 24 weeks. These data support clinical decision-making for ritlecitinib use in severe alopecia areata outside controlled trials.

Starace M, Rapparini L, Pampaloni F et al. · American journal of clinical dermatology · (2026) · View on PubMed ↗

International Expert Opinion on Optimal Switching to Cladribine Tablets from Other High-Efficacy Disease-Modifying Therapies for Relapsing-Remitting Multiple Sclerosis: Opportunities and Challenges.​

This international expert opinion reviewed evidence and clinical practice for switching relapsing-remitting multiple sclerosis patients to cladribine tablets (CladT) from other high-efficacy disease-modifying therapies. The key finding is that optimal switching strategies depend on prior therapy class (anti-trafficking S1P modulators, natalizumab, or anti-CD20 agents) and require balancing immune reconstitution timing and safety. Clinically, it provides guidance to reduce risks such as disease rebound and infection while maximizing efficacy after switching to cladribine.

Chan A, Alroughani R, Calabrese M et al. · Neurology and therapy · (2026) · View on PubMed ↗

Bireociclib Plus Fulvestrant in Advanced Breast Cancer After Endocrine Progression: The BRIGHT-2 Phase 3 Randomized Clinical Trial.​

In a double-blind, placebo-controlled phase 3 randomized clinical trial conducted at 64 hospitals in China, patients with hormone receptor–positive, ERBB2 (HER2)-negative advanced breast cancer after endocrine progression were assigned to bireociclib plus fulvestrant versus placebo plus fulvestrant. The final BRIGHT-2 analysis (with additional follow-up) further evaluated efficacy and safety of bireociclib plus fulvestrant in this HR+/ERBB2− population. If confirmed, this regimen could expand targeted options after endocrine therapy failure by improving outcomes through CDK/kinase inhibition combined with estrogen receptor blockade.

Wang J, Zhang Q, Li H et al. · JAMA oncology · (2026) · View on PubMed ↗

Women with epilepsy: Evidence-based counseling across the lifespan.​

This evidence-based review synthesized data on women with epilepsy across the lifespan, covering adolescence/transition to adult care and reproductive health topics including contraception, fertility, pregnancy, lactation, menopause, and bone health. The review highlights persistent gaps in integrating sex- and life-stage–specific epilepsy management into routine clinical care despite updated guidelines. The work supports more comprehensive, guideline-aligned counseling to improve outcomes beyond seizure control for women at different reproductive and aging stages.

Tettenborn B, Ramantani G, Flügel D et al. · Epilepsia · (2026) · View on PubMed ↗

Cardiovascular Risk, Prognosis & Clinical Outcomes​

USP25 regulates atherosclerosis by restricting RIPK1-mediated inflammatory responses.​

This mechanistic study examined how the deubiquitinase USP25 regulates atherosclerosis by restricting RIPK1-mediated inflammatory responses, using human atherosclerotic lesions and ApoE-/- mouse models. USP25 was downregulated in human lesions, and USP25 promoted anti-inflammatory signalling by limiting RIPK1-driven inflammatory pathways, with macrophages identified as a key cellular source. These results position USP25 as a potential therapeutic target to dampen RIPK1-dependent inflammation in atherosclerotic disease.

Su X, Zhou B, Xu Y et al. · EBioMedicine · (2026) · View on PubMed ↗

Prognostic Impact of Elevated Pulmonary Vascular Resistance in Group 2 Pulmonary Hypertension: Insights From a Japanese Multicenter Registry.​

This Japanese multicenter registry analysis studied the prognostic impact of elevated pulmonary vascular resistance (PVR) in group 2 pulmonary hypertension (PH) due to left heart disease, using two prospective registries (2012–2016 and 2018–2024; total n=988). Higher PVR was associated with worse real-world outcomes including heart failure hospitalization and death, and the analysis also informed how emerging therapies might be interpreted in relation to PVR. The findings help risk-stratify group 2 PH patients and guide selection/assessment of future treatment strategies.

Satoh T, Sugimura K, Fukumoto Y et al. · Journal of the American Heart Association · (2026) · View on PubMed ↗

Trends in 5-year net survival for women diagnosed with breast, cervical or ovarian cancer in Japan, 2000-14 (CONCORD-3).​

This population-based surveillance study used Japanese CONCORD-3 data from 16 cancer registries to analyse trends in 5-year net survival for women diagnosed with breast, cervical, or ovarian cancer from 2000–2014. The authors reported changes over time in survival outcomes stratified by cancer type and age, reflecting improvements and persistent disparities. These long-term trend estimates provide evidence for evaluating cancer control efforts and targeting gaps in outcomes for women in Japan.

Watanabe K, Di Carlo V, Sugiyama H et al. · Japanese journal of clinical oncology · (2026) · View on PubMed ↗

Stroke Risk After Bioprosthetic Aortic Valve Replacement in Aortic Stenosis: Systematic Review and Meta-Analysis.​

This systematic review and meta-analysis quantified the proportion of adults with severe aortic stenosis who experienced ischaemic stroke after bioprosthetic aortic valve replacement, including transcatheter AVR (TAVR), surgical AVR, and valve-in-valve (ViV) replacement. Across included studies, the authors estimated stroke risk within and beyond the periprocedural period after bioprosthetic AVR. The results improve counselling and prognostication by providing pooled, procedure-relevant stroke incidence estimates.

Bou Dargham T, Hassani S, Mac Grory BC et al. · Stroke · (2026) · View on PubMed ↗

Inhibiting RhoA Activation Via GDP-State Stabilization to Relieve Heart Failure.​

This study aimed to inhibit RhoA activation in heart failure by stabilising the GDP state, addressing RhoA’s “undruggable” nature due to high-affinity nucleotide binding. Using structural comparisons of RhoA-GTP versus RhoA-GDP and surface plasmon resonance-based screening, the authors identified a RhoA inhibitor that reduced pathological RhoA signalling and alleviated heart failure-associated remodelling phenotypes. The work provides a proof-of-concept strategy for targeting small GTPases by nucleotide-state stabilisation to treat heart failure.

Xue M, Liang Y, Yuan Z et al. · Circulation research · (2026) · View on PubMed ↗

Glucagon-like peptide-1 receptor agonists for major cardiovascular and kidney outcomes in type 1 diabetes.​

This observational comparative effectiveness study used national electronic health records (n=174,678) and sequential target trial emulation to assess long-term outcomes of GLP-1 receptor agonists in type 1 diabetes. After propensity score weighting, GLP-1RA initiation was associated with lower risks of major adverse cardiovascular events and end-stage kidney disease over 5 years compared with non-initiation. The results provide real-world evidence that GLP-1RAs may confer cardiovascular and renal protection in type 1 diabetes.

Xu Y, Malek ND, Chang AR et al. · Nature medicine · (2026) · View on PubMed ↗

Fibrinogen-Bmal1 signaling as a therapeutic target to limit aortic dissection by preserving VSMC contractility.​

This study investigated fibrinogen–Bmal1 signaling as a therapeutic target to limit aortic dissection (AD) progression by preserving vascular smooth muscle cell (VSMC) contractility, building on prior pilot clinical observations linking higher plasma fibrinogen with better outcomes. It found in nonsurgically managed acute AD patients that fibrinogen-related signaling patterns associate with disease course and that fibrinogen–Bmal1 pathways can be leveraged to maintain VSMC function and reduce progression. This provides a translational rationale for targeting fibrinogen/Bmal1 signaling to slow AD beyond surgery.

Zhong X, Li D, Zhao Y et al. · Signal transduction and targeted therapy · (2026) · View on PubMed ↗

Integration of Epidemiology and Network Toxicology Revealed the Arrhythmogenic Potential of Neonicotinoid Insecticides.​

The study assessed arrhythmogenic potential of neonicotinoid insecticides by measuring urinary neonicotinoids and metabolites in 136 arrhythmia patients and 222 healthy controls. Neonicotinoids were detected in all samples with higher concentrations in patients than controls (except thiamethoxam and clothianidin), and statistical models (quantile g-computation and Bayesian kernel machine regression) suggested that co-exposure to multiple neonicotinoids increased arrhythmia risk. This provides epidemiologic and mixture-toxicity evidence that supports cardiovascular risk assessment for neonicotinoid exposure.

Ge Y, Xiao Q, Fu B et al. · Environmental science & technology · (2026) · View on PubMed ↗

Transradial vs Transfemoral Access for Cerebral Angiography: A Randomized Noninferiority Clinical Trial.​

This randomized noninferiority clinical trial compared transradial access (TRA) versus transfemoral access (TFA) for diagnostic cerebral angiography in patients across 13 sites in China. The key finding was the relative efficacy and safety of TRA compared with TFA, assessed with blinded outcome evaluation in an open-label design. Clinically, it informs procedural access-site choice for cerebral angiography to potentially reduce complications while maintaining diagnostic performance.

Ni W, Yang H, Su J et al. · JAMA network open · (2026) · View on PubMed ↗

Immuno-oncology & Tumor Microenvironment​

Targeting tumor-associated macrophages-induced IGF1/PI3K/Zic1 axis triggers SHH medulloblastoma regression and chemosensitization.​

This study investigated whether targeting tumor-associated macrophages (TAMs)-induced IGF1/PI3K/Zic1 signalling can trigger SHH medulloblastoma regression and chemosensitisation. Using a CD11b-DTR/Ptch1-deficient medulloblastoma mouse model with TAM genetic deletion and pharmacologic inhibition (including the CSF1R inhibitor PLX3397 and PI3K inhibitor buparlisib), the authors showed TAM pathway blockade reduced tumour growth and improved chemosensitivity. The results identify a TAM–IGF1/PI3K/Zic1–SHH axis as a therapeutic vulnerability in medulloblastoma.

Pang YC, Wang C, Qiu JF et al. · Neuro-oncology · (2026) · View on PubMed ↗

Targeting WIP1 reprograms immunosuppressive tumor microenvironment to potentiate immunotherapy response in colorectal cancer.​

The study investigated wild-type p53-induced phosphatase 1 (WIP1/PPM1D) as an immunosuppressive driver in colorectal cancer and tested genetic or pharmacologic WIP1 inhibition in CRC models. It found that inhibiting WIP1 suppressed tumor growth by remodeling the tumor microenvironment, increasing infiltration of anti-tumor macrophages and cytotoxic T cells while dampening type I interferon (IFN) signaling. This positions WIP1 as a target to reverse immunosuppression and potentially potentiate immune checkpoint inhibitor responses in CRC.

Chen L, Chen M, Yuan S et al. · Cell death and differentiation · (2026) · View on PubMed ↗

SHR-A1811, a novel HER2-targeting antibody-drug conjugate, in advanced solid tumors (HORIZON-X): a global phase 1 trial.​

This first-in-human global phase 1 trial evaluated SHR-A1811, a HER2-targeting antibody–drug conjugate, in adults with advanced solid tumors in the HORIZON-X study (NCT04446260). It found that SHR-A1811 (trastuzumab conjugated via a cleavable linker to a topoisomerase I inhibitor payload) showed substantial antitumor activity in heavily treated HER2-expressing or HER2-mutated tumors, with safety and efficacy assessed across dose-escalation cohorts. Clinically, it supports further development of SHR-A1811 as a next-generation HER2 ADC for refractory metastatic disease.

Yao H, Yan M, Tong Z et al. · Signal transduction and targeted therapy · (2026) · View on PubMed ↗

CAV1-DOT1L axis in TAM-derived EVs orchestrates VM and sensitises PDAC to combined VM and VEGF targeting.​

This Gut study investigated how the CAV1–DOT1L axis in tumor-associated macrophage (TAM)-derived extracellular vesicles (EVs) regulates vasculogenic mimicry (VM) and sensitizes pancreatic ductal adenocarcinoma (PDAC) to combined VM and VEGF targeting. It combined histopathology, 3D tissue clearing, spatial transcriptomics, and single-cell RNA-seq with tissue microarrays, co-culture assays, and xenografts to map VM distribution and TAM contributions. The work identifies a TAM EV–epigenetic signaling pathway (CAV1–DOT1L) as a mechanistic driver of VM and a therapeutic lever to improve anti-vascular strategies in PDAC.

Liu Z, Zhang Y, Wu H et al. · Gut · (2026) · View on PubMed ↗

A bispecific nanobody-drug conjugate targeting TROP2 and c-Met for low-concentration, single-dose treatment of pancreatic cancer.​

The study developed B6ADC, a nanobody-based bispecific antibody-drug conjugate targeting TROP2 and c-Met, and evaluated it in TROP2/c-Met-expressing pancreatic cancer cell lines and mouse xenograft models. B6ADC showed potent in vitro cytotoxicity and superior in vivo tumor inhibition versus single-target ADCs and combinations, outperforming clinically used TROP2 ADC sacituzumab govitecan and c-Met ADC Teliso-V. This supports bispecific nanobody-drug conjugate design as a strategy to overcome antigen heterogeneity and improve tumor penetration for low-dose, single-administration pancreatic cancer therapy.

Ning W, Liu H, Zeng H et al. · Cell reports. Medicine · (2026) · View on PubMed ↗

Preferences in Cyclin-Dependent Kinase 4/6 Inhibitors for Advanced Breast Cancer Among Medical Oncologists in Latin America.​

The study surveyed 116 medical oncologists across 15 Latin American countries to characterize preferences and decision-making patterns for CDK4/6 inhibitors in advanced hormone receptor–positive, HER2-negative breast cancer. Ribociclib was the preferred agent (56.8%), with preferences driven by factors related to availability and clinical decision scenarios. These findings highlight regional prescribing/access patterns that can inform guideline implementation and equitable access strategies.

Villarreal-Garza C, Meraz-Brenez A, Reyes Morales A et al. · JCO global oncology · (2026) · View on PubMed ↗

Overcoming T cell tolerance to tumor self-antigens through catch-bond engineering.​

The study engineered catch-bond T cell receptors (TCRs) to overcome central tolerance to tumor self-antigens by targeting the nonmutated tumor-associated antigen prostatic acid phosphatase (PAP). It identified a catch-bonding hotspot mutation that increased TCR–pMHC bond lifetime while preserving physiological affinities and fine specificity, leading to vastly improved T cell expansion, effector phenotypes, and tumor elimination in tumors. This provides a mechanistically grounded TCR engineering strategy to enhance anti-tumor immunity against self-antigens.

Chen X, Mao Z, Kolawole EM et al. · Science (New York, N.Y.) · (2026) · View on PubMed ↗

Long-term outcomes of eribulin‑based neoadjuvant chemotherapy for triple‑negative breast cancer patients stratified by homologous recombination deficiency status: results of the randomized JBCRG-22 study.​

This randomized JBCRG-22 study reported long-term outcomes of eribulin-based neoadjuvant chemotherapy in triple-negative breast cancer (TNBC) stratified by homologous recombination deficiency (HRD) and germline BRCA mutation status. The key finding was the differential long-term outcome of eribulin-containing regimens across HRD-positive versus HRD-negative (and gBRCA-mutated when available) strata. The significance is that HRD/gBRCA status may help personalize neoadjuvant eribulin strategies in TNBC.

Masuda N, Yasojima H, Bando H et al. · Breast cancer research and treatment · (2026) · View on PubMed ↗

Gsα deficiency in macrophages promotes tumor progression via the MAPK signaling pathway.​

This study examined whether Gsα (the G protein alpha subunit) deficiency in tumor-associated macrophages (TAMs) promotes cancer progression through MAPK signaling. In mouse models using B16 and MC38 tumor cells, the authors found that Gsα-deficient TAMs accelerated tumor growth and metastasis, with mechanistic data implicating MAPK pathway activation. The significance is that restoring or targeting Gsα–MAPK signaling in TAMs could represent a strategy to reprogram the tumor microenvironment for cancer immunotherapy.

Yan W, Yang J, Tan S et al. · Journal of molecular medicine (Berlin, Germany) · (2026) · View on PubMed ↗

HTRA1+ macrophages induce T cells egress through CRIP1/NF-κB/CXCL12 to limit the effects of immunotherapy in triple-negative breast cancer.​

In triple-negative breast cancer (TNBC), this study used single-cell and spatial transcriptomics to identify a macrophage subpopulation characterized by high HTRA1 expression that influences immunotherapy response. HTRA1+ macrophages induced T cell egress via a CRIP1/NF-κB/CXCL12 signaling axis, limiting the effectiveness of immunotherapy. Mechanistically defining this pathway suggests a targetable immune-evasion mechanism to improve CD8+ T cell–mediated responses in TNBC.

Weng J, Xu W, Wang F et al. · Cancer immunology research · (2026) · View on PubMed ↗

Albumin-Bound STING Agonist Reprograms HSPCs to Antitumor Neutrophils Enhancing CD8+ T Cell Immunity.​

This preclinical study tested an albumin-bound STING agonist, Nano ZSA-51D, to reprogram hematopoietic stem and progenitor cells (HSPCs) into antitumor neutrophils and enhance CD8+ T cell immunity. Nano ZSA-51D expanded HSPCs, shifted differentiation toward granulocyte-monocyte progenitors, increased MHC I–mediated CD8+ T cell responses, and sensitized tumors to α-PD1 immunotherapy. The findings support STING-agonist–driven myeloid reprogramming as a strategy to overcome resistance to checkpoint blockade.

Tao J, Zhao HY, Li C et al. · Advanced science (Weinheim, Baden-Wurttemberg, Germany) · (2026) · View on PubMed ↗

Cancer Biomarkers, Diagnostics & Imaging​

Liquid biopsy for the diagnosis of EBV-positive Burkitt's lymphoma in endemic areas.​

This diagnostic study evaluated liquid biopsy approaches for Epstein–Barr virus (EBV)-positive Burkitt’s lymphoma in endemic settings by testing blood-based assays in 377 children and young adults with suspected lymphoma across hospitals in Tanzania and Uganda. Using circulating tumor DNA markers (including MYC mutations, MYC–immunoglobulin translocations, and EBV fragmentomics) alongside clinical features, the authors trained models to improve diagnostic accuracy and reduce turnaround time compared with delayed pathology. The findings support scalable, pathology-light diagnostic strategies for EBV-positive BL in resource-limited regions.

Chamba C, Christopher H, Josephat E et al. · Nature medicine · (2026) · View on PubMed ↗

Extrachromosomal DNA in urothelial carcinoma: mechanisms and clinical applications.​

The study reviewed how extrachromosomal DNA (ecDNA) drives genomic instability and tumor evolution in urothelial carcinoma and how ecDNA can be detected using sequencing/imaging and liquid biopsy or histopathology-based inference. It found that ecDNA amplifies oncogenes, alters 3D chromatin interactions, reprograms transcription, and shapes the tumor–immune interface, thereby accelerating APOBEC3-associated mutational evolution and promoting aggressive intratumour heterogeneity. These mechanisms and detection approaches support ecDNA as a clinically actionable biomarker and potential therapeutic target in urothelial cancer.

Li C, Hu Z, Zhang W et al. · Nature reviews. Urology · (2026) · View on PubMed ↗

Prognostic Significance of MSI and EBV Positivity in PD-L1 Positive Gastric Cancer: A Systematic Review and Meta-Analysis.​

This systematic review and meta-analysis assessed the prognostic significance of microsatellite instability (MSI), Epstein–Barr virus (EBV) positivity, and PD-L1 expression specifically in PD-L1–positive gastric cancer. It synthesized studies (Jan 2010–Dec 2024) using MSI testing (PCR), PD-L1 immunohistochemistry, and EBV in situ hybridization to evaluate overall survival and other endpoints. The analysis aims to refine risk stratification and immunotherapy-related decision-making in gastric cancer using combined biomarker status.

Petrelli F, Antista M, Ghidini A et al. · Cancer medicine · (2026) · View on PubMed ↗

A predictive atlas of disease onset from retinal fundus photographs: a modelling study using data from population-based cohorts.​

This modeling study used retinal fundus photographs from population-based cohorts to build a predictive atlas for incident disease onset across the human phenome. It found that retinal imaging can predict future onset of multiple diseases and can add value beyond baseline clinical information (as benchmarked in the study). This supports retinal fundus photography as a scalable, non-invasive screening tool for early identification of individuals at high risk for diverse conditions.

Buergel T, Loock L, Steinfeldt J et al. · The Lancet. Digital health · (2026) · View on PubMed ↗

Risk Assessment in Large B-Cell Lymphoma Using Metabolic Tumor Volume: Real-World Data from a Multicenter Cohort of Patients Undergoing CAR T-Cell Therapy.​

This real-world multicenter cohort study evaluated whether PET-derived metabolic tumor volume (MTV) improves risk assessment in large B-cell lymphoma (LBCL) patients undergoing CAR T-cell therapy compared with the International Prognostic Index (IPI). It analyzed 18F-FDG-avid lymphoma burden/MTV-based risk scores in 111 patients to predict outcomes and identify potential nonresponders before infusion. Scientifically and clinically, it supports MTV quantification as a more informative biomarker for pre-treatment stratification in CAR T workflows.

Voltin CA, Flossdorf S, Kurch L et al. · Journal of nuclear medicine : official publication, Society of Nuclear Medicine · (2026) · View on PubMed ↗

Clinical practice guideline for long COVID prevention and treatment.​

This multicentre study developed and validated a multimodal fusion model to non-invasively prognosticate survival in hepatocellular carcinoma (HCC) patients treated with transarterial chemoembolisation (TACE). It enrolled 1448 patients and used pre-treatment contrast-enhanced CT images integrated with hypoxia- and immune-phenotype information derived from single-cell RNA-seq and TCGA to improve generalisability and biological interpretability over existing scores. The model could enable more precise, biologically grounded survival prediction to guide TACE management.

Cao B, Soriano JB, Wang Q et al. · The European respiratory journal · (2026) · View on PubMed ↗

Post hoc estimation of a quantitative restriction spectrum imaging biomarker for prostate cancer detection using conventional MRI.​

This study evaluated whether restriction spectrum imaging (RSI) metrics (RSIrs) for prostate cancer detection can be estimated post hoc from conventional MRI diffusion-weighted imaging (DWI) rather than requiring dedicated multi–b-value acquisitions. The key finding was the accuracy/validity of post hoc RSI-derived quantitative biomarkers for detecting clinically significant prostate cancer (csPCa). If validated, this would enable broader deployment of RSI-like quantitative biomarkers using standard MRI protocols.

Do DD, Conlin CC, Bagrodia A et al. · Journal of applied clinical medical physics · (2026) · View on PubMed ↗

Machine Learning-Based Sleep Electroencephalographic Brain Age Index and Dementia Risk: An Individual Participant Data Meta-Analysis.​

This individual participant data meta-analysis assessed whether a machine learning-based sleep EEG brain age index (BAI) predicts incident dementia in community-dwelling populations. Pooling data from five longitudinal cohorts, the study tested the association between sleep EEG-based brain age (deviation from chronological age) and future dementia risk. The significance is that sleep EEG BAI could serve as a scalable, quantitative risk biomarker for dementia stratification.

Sun H, Milton S, Fang Y et al. · JAMA network open · (2026) · View on PubMed ↗

Diagnostic Performance of Anti-Epstein-Barr Virus BNLF2b in Suspected Nasopharyngeal Carcinoma.​

This prospective, multicenter outpatient study evaluated the diagnostic performance of the novel anti–EBV BNLF2b total antibody (P85-Ab) assay for suspected nasopharyngeal carcinoma (NPC) and compared it head-to-head with EBV VCA-IgA, EBV EA-IgA, and EBNA1-IgA. P85-Ab showed diagnostic accuracy for suspected NPC that was benchmarked against established EBV serologic markers. Clinically, identifying the most reliable EBV biomarker could improve early NPC detection and reduce misdiagnosis in routine outpatient practice.

Li SC, Li FG, Wu SJ et al. · JAMA oncology · (2026) · View on PubMed ↗

Use of ctDNA in Older Women with ER+ Breast Cancer to Facilitate Surgical De-escalation: A Prospective, Hybrid-Decentralized Trial with Correlative Studies.​

In a prospective, hybrid-decentralized trial (NCT05914792; n=43) of older women with ER+ breast cancer, researchers used circulating tumor DNA (ctDNA) to determine whether ctDNA levels predict tumor progression in patients who chose surgical de-escalation (forgoing breast cancer surgery in favor of primary endocrine therapy). ctDNA was evaluated as a prognostic biomarker to facilitate safe treatment de-escalation, with correlative tissue analyses integrated into the study. If validated, ctDNA-guided selection could reduce overtreatment while maintaining oncologic safety in older patients with competing comorbidities.

Carleton N, Chang AC, Chen F et al. · Clinical cancer research : an official journal of the American Association for Cancer Research · (2026) · View on PubMed ↗

Molecular Mechanisms of Cancer (Metabolism/Epigenetics/Signaling)​

Hijacking ERAD for targeted degradation of transmembrane proteins.​

This study developed a targeted protein degradation (TPD) platform that hijacks ER-associated degradation (ERAD) to degrade transmembrane proteins, creating ERAD-engaging chimeras (ERADECs), and tested it by targeting programmed death-ligand 1 (PD-L1) in cells. The authors identified desonide as a binder of the ER E3 ligase SYVN1 and showed ERADECs efficiently degraded PD-L1 by recruiting SYVN1-mediated ERAD. This provides a mechanistic route to drug discovery for otherwise hard-to-degrade transmembrane targets using ERAD machinery.

Song H, Wang W, Mei T et al. · Cell · (2026) · View on PubMed ↗

Lactylation Converts ABHD6 into a Mitochondrial Regulator that Drives Lenvatinib Resistance in Hepatocellular Carcinoma.​

This cancer biology study investigated how lactylation alters ABHD6 function to drive lenvatinib resistance in hepatocellular carcinoma (HCC), focusing on mitochondrial dynamics and the ABHD6 S148 catalytic site. Lactylation converted ABHD6 into a mitochondrial regulator that promotes lenvatinib resistance through a pro-resistance scaffolding function that is independent of ABHD6 catalytic activity but requires an unoccupied S148 site. The work suggests targeting ABHD6 lactylation-dependent switching or its mitochondrial effects as a strategy to overcome lenvatinib resistance in HCC.

Sun Y, Luo C, Yang H et al. · Cancer research · (2026) · View on PubMed ↗

Histone lactylation-driven feedback loop modulates pyrimidine metabolism to promote oral carcinogenesis.​

This study evaluated whether lactate-dependent histone lactylation regulates pyrimidine metabolism to promote oral squamous cell carcinoma (OSCC) and tested the mechanism in oral leukoplakia (OLK) and OSCC. It found that histone lactylation levels were increased in OLK/OSCC and that blocking lactylation via glycolysis inhibitors or silencing LDHA (lactate dehydrogenase A) promoted anti-tumor effects, supported by CUT&Tag, scRNA-seq, and ChIP-qPCR analyses. Scientifically, it links a lactate-driven epigenetic mark to metabolic reprogramming in oral carcinogenesis, suggesting lactylation/metabolism as a therapeutic vulnerability.

Wang Y, Geng Y, Chen Y et al. · Cell death & disease · (2026) · View on PubMed ↗

Mitoxyperilysis: fasting-induced cell death in immunometabolism and disease.​

This review summarized evidence for mitoxyperilysis, a fasting-induced lytic cell death mechanism driven by mitochondrial proximity-dependent rupture of the plasma membrane. It concluded that mitoxyperilysis is triggered by immune agonists combined with fasting/nutrient starvation and has therapeutic implications in sepsis and cancer. The concept links immunometabolism to a distinct cell-death pathway that could be exploited for treatment.

Al-Zidan R, Gautam M, Man SM · Trends in biochemical sciences · (2026) · View on PubMed ↗

A CHKA-PML autophagy checkpoint enables tumors to evade glutamine starvation.​

This study examined how glutamine scarcity affects tumor-cell survival mechanisms involving choline kinase alpha (CHKA) and promyelocytic leukemia (PML) in cancer models. The authors found that glutamine deprivation upregulates CHKA, whose monomerization drives noncanonical kinase activity that phosphorylates PML at tyrosine 339 to promote cytoplasmic PML, thereby enabling tumors to evade a glutamine-starvation autophagy checkpoint. These findings identify a CHKA–PML compartment-specific signaling switch as a potential therapeutic target to block tumor adaptation to nutrient stress.

Wang R, Cao L, He X et al. · Proceedings of the National Academy of Sciences of the United States of America · (2026) · View on PubMed ↗

Unveiling the multifaceted roles of BCL3: biological functions and disease implications.​

This review detailed the multifaceted roles of the NF-κB pathway regulator BCL3 (B-cell CLL/lymphoma 3) in normal biology and disease. The key finding is that BCL3, unlike classical IκB proteins, predominantly localizes to the nucleus and can bidirectionally regulate NF-κB–dependent transcription, with phosphorylation and other post-translational modifications tuning its activity. Scientifically, it frames BCL3 as an oncogenic driver in multiple hematologic malignancies and a potential therapeutic target.

Guo X, Guo R, Wang W et al. · Apoptosis : an international journal on programmed cell death · (2026) · View on PubMed ↗

Disruption of iron homeostasis by HERC2-FTL axis leads to chondrocyte loss and exacerbates osteoarthritis.​

This study investigated how disruption of iron homeostasis via the HERC2–FTL axis affects chondrocyte survival and osteoarthritis (OA) progression. Using ATDC5 chondrocytes treated with IL-1β or the ferroptosis inducer erastin, the authors found that altering HERC2 (knockdown/overexpression) modulated ferroptosis, autophagy, oxidative stress, and cartilage matrix protein expression, linking HERC2-driven iron regulation to chondrocyte loss. Scientifically, it identifies the HERC2–FTL pathway as an upstream regulator of ferroptosis in OA and a potential therapeutic target.

Zhong Y, Duan J, Chen Z et al. · Apoptosis : an international journal on programmed cell death · (2026) · View on PubMed ↗

The therapeutic potential of Piezo1 channel-mediated ferroptosis and its inhibitor.​

This review described the therapeutic potential of Piezo1 channel-mediated ferroptosis and discussed how ferroptosis inhibition might be leveraged. It explains that Piezo1 activation increases Ca2+ influx, reprograms iron metabolism through TfR1-dependent iron uptake, DMT1-mediated transport, and NCOA4-regulated ferritinophagy, leading to ROS accumulation and lipid peroxidation that culminates in ferroptosis. The significance is that Piezo1–ferroptosis signaling could be targeted to induce tumor cell death or modulated to protect tissues depending on context.

Nan K, Zhang L, Zhao Y et al. · Apoptosis : an international journal on programmed cell death · (2026) · View on PubMed ↗

Phospholipid Glutathione Peroxidase Overexpression Mitigates Cancer Cachexia by Protecting Muscle Mass and Lowering Inflammation.​

This study investigated whether overexpressing phospholipid glutathione peroxidase (GPx) can mitigate cancer cachexia by protecting muscle mass and reducing inflammation. Phospholipid GPx overexpression lowered inflammatory burden and preserved muscle, counteracting cachexia-associated muscle wasting. The results position lipid-peroxidation control via phospholipid GPx as a candidate therapeutic approach for cancer cachexia.

Duggan E, Fuqua JD, Hagy B et al. · Journal of cachexia, sarcopenia and muscle · (2026) · View on PubMed ↗

Regulation of YAP activity by nuclear G-actin binding.​

This mechanistic study investigated how nuclear G-actin binding regulates the activity of YAP, a transcriptional co-activator in the Hippo pathway. The authors showed that binding of monomeric actin (G-actin) in the nucleus modulates YAP activity and thereby influences YAP-dependent transcriptional programs. Understanding this actin–YAP regulatory mechanism clarifies how cytoskeletal dynamics and mechanotransduction control proliferation and cancer-related behaviors.

Wang H, Jayawardana IM, Fleisch JM et al. · Nucleic acids research · (2026) · View on PubMed ↗

Infectious Disease & Host–Virus Interactions​

LRP8 is a functional receptor for yellow fever virus.​

This study identified LRP8 (APOER2) as a functional receptor for yellow fever virus (YFV) by performing a barcoded genome-wide human open reading frame library screen. LRP8 expression increased infection by the live-attenuated 17D vaccine strain and clinical strains (BJ01 and Asibi) by promoting viral entry, and LRP8 expression in mouse liver via adeno-associated virus worsened infection and pathology for BJ01. The work clarifies receptor usage differences among YFV strains and suggests LRP8 as a potential target to modulate infection.

Mei M, Yang Y, Zhang Z et al. · Nature microbiology · (2026) · View on PubMed ↗

ALG6 orchestrates coronavirus replication via the endoplasmic reticulum stress-autophagy axis.​

This study investigated the host factor alpha-1,3-glucosyltransferase ALG6 and its relationship to ER stress and autophagy during coronavirus replication, using transmissible gastroenteritis virus (TGEV) models. ALG6 catalytic activity was required for TGEV replication, and ALG6 knockout inhibited viral entry by downregulating the receptor aminopeptidase N (ANPEP) while also triggering ER stress that suppressed viral replication. The work positions ALG6 as a druggable node linking ER stress–autophagy pathways to coronavirus life cycle control.

Fu Y, Gao M, Fu Z et al. · Cell reports · (2026) · View on PubMed ↗

Association between COVID-19 vaccination and sudden death in apparently healthy younger individuals: A population-based case-control study.​

This population-based case-control study assessed whether COVID-19 vaccination is associated with sudden death in apparently healthy younger individuals aged 12–50 years in Ontario, Canada using linked administrative datasets. The key finding was the estimated association between vaccination exposure and sudden death risk in this age group (with the study designed to quantify whether any increased risk is detectable despite rarity). Clinically, the results inform risk-benefit counseling and post-vaccination safety surveillance for rare but serious outcomes in younger populations.

Abdel-Qadir H, Bhatt HA, Swayze S et al. · PLoS medicine · (2026) · View on PubMed ↗

Gene Editing & Functional Genomics Tools​

Embedded CRISPRi Enhances Gene-Silencing Efficiency in Drosophila.​

This study developed embedded CRISPR interference (emCRISPRi) in Drosophila melanogaster by engineering transcriptional repression domains (Mxi and TRD) into a flexible region of catalytically inactive Cas9 (dCas9). emCRISPRi significantly increased gene-silencing efficiency and repression amplitude, especially for coding genes and cis-regulatory elements near transcription start sites (TSS). The platform improves the reliability of CRISPRi functional genomics in flies and enables more robust interrogation of TSS-proximal regulatory mechanisms.

Fu P, Zhang X, Zhou Y et al. · Advanced science (Weinheim, Baden-Wurttemberg, Germany) · (2026) · View on PubMed ↗

Human DHX29 detects nonoptimal codon usage to regulate mRNA stability.​

The study investigated how the human RNA helicase DHX29 detects nonoptimal codon usage to regulate mRNA stability. Using genome-wide CRISPR screening plus cryogenic electron microscopy and selective ribosome profiling, it showed DHX29 directly interacts with the A-site entrance of the translating 80S ribosome to monitor aminoacyl-tRNA sampling. This clarifies a human mechanism linking codon usage to mRNA decay control, informing how translation quality shapes gene expression.

Hia F, Wu Y, Yoshinaga M et al. · Science (New York, N.Y.) · (2026) · View on PubMed ↗

Unstructured transcription factor interactions enable emergent specificity.​

The study examined how intrinsically disordered regions (IDRs) enable emergent specificity in transcription factor interactions and chromatin binding. Using proximity-assisted photoactivation (PAPA) in live cells, it found that the Sp1 DNA-binding domain interacts weakly with chromatin, while IDR fusion enhanced interaction and conferred sharp locus specificity on an otherwise nonspecific DNA-binding domain. This demonstrates an experimental framework for understanding how IDRs tune transcription factor targeting in vivo.

Abidi AA, Cattoglio C, Tang NN et al. · Science (New York, N.Y.) · (2026) · View on PubMed ↗

Neuroimmunology & Neuroinflammation​

Postural Orthostatic Tachycardia Syndrome, Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Long COVID as Neuroimmune Disorders.​

This article is a mechanistic synthesis proposing that postural orthostatic tachycardia syndrome (POTS), myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), and Long COVID can be conceptualised as neuroimmune disorders with overlapping pathophysiology. It emphasises shared contributors such as autonomic dysfunction, immune dysregulation/autoimmunity, mitochondrial dysfunction, cerebral hypoperfusion, and neuroinflammation. The framework may help unify research and guide development of targeted therapies across these related syndromes.

Blitshteyn S, Doherty TA, Steinman L · ImmunoTargets and therapy · (2026) · View on PubMed ↗

CD177⁺ neutrophil-platelet aggregates contribute to thromboinflammation via NETs in necrotizing enterocolitis.​

This study examined necrotizing enterocolitis (NEC) pathogenesis by focusing on CD177+ neutrophil–platelet aggregates and their contribution to thromboinflammation via neutrophil extracellular traps (NETs) in premature infants and neonatal mouse models. It found that NEC is characterized by immunothrombosis with infiltrating CD177+ neutrophils and activated platelets, and that these aggregates promote NET-driven thromboinflammatory processes. The findings identify a specific immunothrombotic cell interaction axis as a potential mechanistic target to prevent or treat NEC.

Lan C, Tian B, Shi Y et al. · Nature communications · (2026) · View on PubMed ↗

Quantifying immune dysregulation in pneumonia and sepsis with a parsimonious machine-learning model: a multicohort analysis across care settings and reanalysis of a hydrocortisone randomised controlled trial.​

This multicohort analysis developed a parsimonious machine-learning model to quantify immune dysregulation in pneumonia and sepsis and reanalyzed data from a hydrocortisone randomized controlled trial. It aimed to measure dysregulation directly rather than rely solely on clinical severity for immunomodulation trial enrollment, thereby addressing heterogeneity in treatment response. The approach supports biologically informed prognostication and could help identify patients most likely to benefit from immune-targeted therapies.

Michels EHA, Dequin PF, Butler JM et al. · The Lancet. Respiratory medicine · (2026) · View on PubMed ↗

Psoriasis modulates inflammatory bowel disease risk and intestinal epithelium lipid metabolism via IL-1β-producing macrophages.​

The study investigated how psoriasis affects inflammatory bowel disease risk and intestinal epithelial lipid metabolism, combining a clinical cohort with experimental psoriasis mouse models and intestinal organoid assays. Psoriasis severity inversely correlated with postprandial plasma apolipoprotein B48 levels, and the authors used a recombinant photoconvertible apolipoprotein B reporter to show real-time chylomicron production changes driven by IL-1β-producing macrophage–linked mechanisms. This links psoriasis-associated immune activity to impaired intestinal lipid handling, providing mechanistic insight into the psoriasis–IBD comorbidity.

Wu J, Liu S, Dan W et al. · Cell metabolism · (2026) · View on PubMed ↗

A neuroimmune circuit links stress to skin inflammation.​

The study investigated a neuroimmune mechanism connecting stress to skin inflammation, focusing on sympathetic neurons and eosinophils in atopic dermatitis flare contexts. It found that sympathetic neurons activate eosinophils during stress, worsening atopic dermatitis inflammation. This identifies a stress-responsive neuroimmune circuit as a potential therapeutic target for inflammatory skin disease.

Gaudenzio N, Basso L · Science (New York, N.Y.) · (2026) · View on PubMed ↗

A sympathetic-eosinophil axis orchestrates psychological stress to exacerbate skin inflammation.​

The study defined how psychological stress exacerbates skin inflammation through a sympathetic-eosinophil axis in mouse models of atopic dermatitis-like disease. It identified prodynorphin-positive (Pdyn+) noradrenergic sympathetic neurons innervating hairy skin that worsen inflammation in an eosinophil-dependent manner, with CCL11–CCR3 signaling mediating eosinophil recruitment. These mechanistic insights connect specific neuronal subtypes and chemokine pathways to stress-driven immune pathology in dermatitis.

Tian J, Cao Y, Li Y et al. · Science (New York, N.Y.) · (2026) · View on PubMed ↗

Hypothalamic clock governs circadian pain.​

The study investigated how the hypothalamic circadian clock regulates pain by measuring nociceptive threshold rhythms in a mouse model of neuropathic pain. It found that daily oscillations are driven by a circuit from the suprachiasmatic nucleus (SCN) to descending analgesia pathways, where daytime increased SCNVIP activity raises nociceptive sensitivity and nighttime reduced activity decreases pain. This links hypothalamic clock neurons (VIP) to circadian pain control, suggesting timing-based approaches for pain management.

Wei HR, Lou Q, Li LX et al. · Science (New York, N.Y.) · (2026) · View on PubMed ↗

From chronic pain to depression: Neurogenesis-driven microglial remodeling in the hippocampal dentate gyrus.​

The study examined how chronic pain transitions to depression by integrating human neuroimaging (UK Biobank) with a rodent model and hippocampal dentate gyrus analyses. It found biphasic hippocampal remodeling—volume increases early with cognitive improvements but declines with comorbid depression—and that dentate gyrus lesions prevented affective symptoms. In rodents, increased dentate gyrus activity drove hyperactive newborn neurons and microglial recruitment/remodeling, implicating neurogenesis-driven microglial remodeling as a mechanistic bridge from pain to depression.

Ding M, Xiang S, Zhang Y et al. · Science (New York, N.Y.) · (2026) · View on PubMed ↗

Astrocytes at the crossroads of obstructive sleep apnea and Alzheimer's disease: from oxygen sensing to neurodegeneration.​

This review examined mechanistic links between obstructive sleep apnea (OSA) and Alzheimer’s disease (AD) with a focus on astrocytes, oxygen sensing, and neurodegeneration. It synthesizes evidence that intermittent hypoxia and sleep fragmentation can drive astrocyte-mediated pathways that contribute to neuroinflammation and AD-relevant pathology. The significance is that astrocytes are proposed as a mechanistic bridge connecting OSA risk to AD progression, suggesting potential intervention points.

Cabot J, Soriano JB, Alonso-Fernández A et al. · Sleep & breathing = Schlaf & Atmung · (2026) · View on PubMed ↗

Interplay of oxidative stress and neuroinflammation in alzheimer's: insights into age-driven pathogenesis.​

This article reviewed how oxidative stress and neuroinflammation interact in Alzheimer’s disease (AD) with emphasis on age-driven mechanisms. It highlights that mitochondrial dysfunction increases reactive oxygen species (ROS), promotes amyloid-β accumulation and cognitive decline, and that inflammasome signaling involving NLRP3 and NF-κB in microglia/astrocytes sustains a neuroinflammatory environment. The significance is that targeting the oxidative stress–neuroinflammation axis may offer disease-modifying opportunities in age-associated AD.

Firdous SM, Chakrabortty S, Undale VR et al. · Inflammopharmacology · (2026) · View on PubMed ↗

Therapeutic Potential of Somatostatin and Its Analogues in Alzheimer's Disease: From Molecular Mechanisms to Preclinical Studies.​

This review evaluated the therapeutic potential of somatostatin (SST) and somatostatin analogues (SSAs) in Alzheimer’s disease, integrating molecular mechanisms with preclinical evidence. It highlights that SST receptors (SSTR1–5) influence amyloid-β metabolism, tau phosphorylation, neuroinflammation, and synaptic plasticity, and that SSAs may enhance amyloid clearance via neprilysin activation and attenuate tau pathology and inflammatory signaling in preclinical studies. The clinical significance is that SSAs could be repurposed as multitarget disease-modifying candidates for AD beyond symptomatic therapies.

Liu K, Zhang XY, Wang YT et al. · Molecular neurobiology · (2026) · View on PubMed ↗

Meat Consumption and Cognitive Health by APOE Genotype.​

This population-based cohort study in the Swedish National Study on Aging and Care-Kungsholmen (SNAC-K) tested whether meat consumption is associated with cognitive health differently by APOE genotype (ε3/ε4 and ε4/ε4 vs other genotypes) over 15 years. Higher meat consumption was linked to cognitive health benefits specifically in APOE ε4 carriers (APOE34/44), with genotype-dependent differences compared with non-ε4 genotypes. These findings support genotype-informed dietary prevention strategies for Alzheimer disease risk in older adults.

Norgren J, Carballo-Casla A, Grande G et al. · JAMA network open · (2026) · View on PubMed ↗

Transcriptomic Insights Into Alzheimer's Disease: Differentially Expressed Genes and Cholesterol Metabolism.​

This computational study applied Mendelian randomization and advanced machine learning to transcriptomic data to characterize differentially expressed genes and cholesterol metabolism pathways in Alzheimer disease. It identified transcriptomic features linking AD biology to cholesterol-related dysregulation. Scientifically, these integrative analyses suggest candidate pathways and gene targets that could support earlier diagnosis and mechanistic stratification of AD.

Sun R, Wang X, Wang Z et al. · CNS neuroscience & therapeutics · (2026) · View on PubMed ↗

The relationship between dietary patterns and neuroinflammation.​

This critical review examined how dietary patterns modulate neuroinflammation through immunometabolic mechanisms affecting the central nervous system (CNS). It synthesizes evidence that nutrient quality/composition/timing can influence glial activation, microglial inflammatory signaling, and vulnerability to neuroinflammatory disorders such as Alzheimer disease and major depression. The review supports dietary pattern interventions as potential modulators of neuroinflammation and highlights mechanistic targets for future research.

Medoro A, Scapagnini G, Hu FB et al. · Critical reviews in food science and nutrition · (2026) · View on PubMed ↗

Early-Life Melatonin Supplementation Reduces the Long-Term Behavioral, Morphological, and Molecular Alterations in a Rat Model of Autism Spectrum Disorder.​

In a rat model of autism spectrum disorder (ASD), this study tested whether early-life melatonin supplementation reduces long-term behavioral, morphological, and molecular abnormalities. Melatonin administration mitigated persistent ASD-like alterations across behavioral and biological readouts. These findings suggest early melatonin as a potential neuroprotective, anti-inflammatory/antioxidant intervention strategy for ASD-related pathology.

Hernández-Sierra LJ, Salgado-Delgado RC, Ibáñez-Sandoval O et al. · Journal of pineal research · (2026) · View on PubMed ↗

Microbiome–Gut–Brain/Host Metabolism​

How gut microbiota contribute to neuropsychiatric disorders: evidence from neuroimaging studies.​

This review synthesised evidence from neuroimaging studies on how gut microbiota contribute to neuropsychiatric disorders via the microbiota–gut–brain axis. It highlights multimodal imaging approaches—including MRI, PET, and diffusion tensor imaging—that link microbial alterations to brain structure and function across neurodevelopmental, neurodegenerative, autoimmune, and psychiatric conditions. The review frames neuroimaging biomarkers as tools to clarify mechanisms and stratify patients in microbiome-related neuropsychiatric research.

Jia C, Zhu W, Yuan Y et al. · Frontiers in microbiology · (2026) · View on PubMed ↗

Commensal-driven serotonin production modulates in vivo delivery of synthetic and viral vectors.​

The study examined how gut microbiota–derived serotonin production affects in vivo delivery efficiency of intestinal epithelial–triggered hepatic delivery systems for synthetic and viral vectors. It showed that disrupting commensal-host interactions improves IDS-based delivery by reducing hepatic IDS clearance, and that transient serotonin signaling suppression (via receptor blockade or diet) mitigates clearance and increases delivery efficiency by more than threefold. This provides a microbiome-informed strategy to enhance gene/drug vector delivery in vivo.

Wang Q, Chen Z, Zhang G et al. · Science (New York, N.Y.) · (2026) · View on PubMed ↗

Gut microbe-derived N-acyl serinol lipids shape host postprandial metabolic homeostasis.​

The study investigated how gut microbe-derived N-acyl serinol lipids influence host postprandial metabolic homeostasis. It focused on N-acyl amide lipid metabolites produced by gut bacteria after meals and assessed their physiological roles in postprandial metabolic responses. This supports a specific diet–microbe–host signaling axis that could be leveraged for microbiome-inspired metabolic therapies.

Dutta S, Mahen KK, Massey WJ et al. · Proceedings of the National Academy of Sciences of the United States of America · (2026) · View on PubMed ↗

Metabolic Disease, Obesity & Systemic Risk​

Joint TOS/OMA/OAC expert guidance statement on the pharmacological management of United States adults with overweight or obesity using the GRADE approach.​

This expert guidance statement used the GRADE approach to synthesise evidence and provide recommendations for pharmacological management of US adults with overweight or obesity, including the role of FDA-approved obesity medications. The guidance addresses clinical decision-making in the context of barriers such as underdiagnosis, limited clinician training, stigma, and reimbursement restrictions. The statement is intended to standardise evidence-based obesity pharmacotherapy and improve access and outcomes at the population level.

Alexander L, Purnell JQ, Burridge K et al. · Obesity pillars · (2026) · View on PubMed ↗

Skeletal muscle metabolism in health and disease: Mechanisms, interventions, and clinical perspectives.​

This iScience review summarised skeletal muscle metabolism in health and disease, focusing on mechanisms of metabolic flexibility and how disruptions in pathways such as insulin, AMPK, mTOR, and PGC-1α contribute to mitochondrial dysfunction, lipid dysregulation, and muscle wasting. It also discussed interventions and clinical perspectives relevant to metabolic disorders including obesity, type 2 diabetes, and sarcopenia. The review integrates molecular regulation with translational opportunities for improving muscle and systemic metabolic health.

Lin D, Zhang L, Huang C et al. · iScience · (2026) · View on PubMed ↗

Type 2 diabetes mellitus.​

This Nature Reviews Disease Primer synthesized evidence on type 2 diabetes mellitus (T2DM) across populations, focusing on epidemiology, risk factors, and disease progression patterns including early-onset T2DM. It concluded that rising obesity is a major driver of increasing T2DM prevalence and that diagnosis before age 40 is linked to more aggressive progression, higher complication burden, and greater lifetime morbidity than later-onset disease. Clinically, this supports earlier risk identification and tailored prevention strategies for younger patients at high risk.

Davies MJ, Lim S, Slater T et al. · Nature reviews. Disease primers · (2026) · View on PubMed ↗

Adherence to the EAT-Lancet Diet and Risk of Sepsis: A Prospective Cohort Study from the UK Biobank.​

This prospective cohort study in 199,085 UK Biobank participants assessed whether adherence to the EAT-Lancet diet is associated with sepsis risk, incorporating genetic susceptibility and proteomic mechanisms. It found that higher EAT-Lancet diet adherence was associated with a reduced risk of sepsis (HR 0.85, 95% CI 0.78–[truncated]). The results suggest diet quality may be a modifiable factor influencing sepsis risk through metabolic/inflammatory pathways relevant to precision prevention.

Nan W, Huang Q, He B et al. · NPJ science of food · (2026) · View on PubMed ↗

The efficacy and safety of cannabinoids for the treatment of mental disorders and substance use disorders: a systematic review and meta-analysis.​

This systematic review and meta-analysis evaluated the efficacy and safety of cannabinoids as primary treatments for mental disorders and substance use disorders (SUDs) based on randomized controlled trials. It concluded that the evidence base from RCTs was assessed across multiple databases (1980–May 13, 2025) to determine treatment effects and adverse outcomes for cannabinoid interventions. The findings aim to clarify whether cannabinoids provide clinically meaningful benefit and acceptable safety profiles for psychiatric and SUD indications.

Wilson J, Dobson O, Langcake A et al. · The lancet. Psychiatry · (2026) · View on PubMed ↗

The relationship between sarcopenia and all-cause and cardiovascular mortality risk among middle-aged and older adults across stages 0-3 of cardiovascular-kidney-metabolic syndrome: evidence from NHANES and CHARLS.​

The study analyzed associations between sarcopenia and all-cause and cardiovascular mortality across cardiovascular-kidney-metabolic (CKM) syndrome stages 0–3 using NHANES (2011–2018) and CHARLS (2011–2020). Using multivariable Cox regression, it evaluated whether sarcopenia status modifies mortality risk within CKM stage strata in middle-aged and older adults. This helps refine risk stratification by linking body composition (sarcopenia) to mortality outcomes in CKM disease trajectories.

Chen Y, Liu Y, Liu S et al. · Cardiorenal medicine · (2026) · View on PubMed ↗

MASLD as a systemic metabolic disease: expanding the scope of cardiovascular-kidney-metabolic (CKM) syndrome.​

This article reviewed metabolic dysfunction-associated steatotic liver disease (MASLD) as a systemic disease and argued for its inclusion within the cardiovascular–kidney–metabolic (CKM) syndrome framework. The key finding is that MASLD increases cardiovascular and renal complications through shared mechanisms such as insulin resistance, low-grade inflammation, oxidative stress, dyslipidemia, and procoagulant states. Clinically, reframing MASLD as part of CKM syndrome could improve cross-specialty screening and management strategies.

Zhou XD, Fan QY, Targher G et al. · Science China. Life sciences · (2026) · View on PubMed ↗

International Dermoscopy Society consensus recommendations for the management of lentigo maligna.​

This consensus statement from the International Dermoscopy Society provided evidence-based recommendations for managing lentigo maligna (LM), a melanoma in situ subtype common on chronically sun-damaged skin in elderly patients. It addresses practical diagnostic and management guidance in settings where evidence is limited and lesions may have subclinical peripheral extension. The recommendations aim to standardize dermoscopic evaluation and treatment decisions to reduce under- or overtreatment of LM.

Forsea AM, Pampena R, Akay BN et al. · Journal of the European Academy of Dermatology and Venereology : JEADV · (2026) · View on PubMed ↗

Renal & Urogenital Disease Mechanisms/Outcomes​

Host-derived nitrate fuels indole production by Escherichia coli to drive chronic kidney disease progression.​

The study explored how host-derived nitrate fuels microbial indole production to drive chronic kidney disease progression in adenine-induced CKD mice. It showed that impaired indoxyl sulfate clearance increases iNOS expression, elevates luminal nitrate, and promotes Escherichia coli growth via nitrate respiration, while CKD patient fecal microbiota produced more indole under anaerobic conditions. This connects host nitrogen metabolism, E. coli nitrate respiration, and indole/indoxyl sulfate pathways to CKD progression.

Lee JY, Mahan SP, Parente de Carvalho T et al. · Science (New York, N.Y.) · (2026) · View on PubMed ↗

Proteomic analyses of human islets reveal potential markers of β-cell dysfunction during prediabetes.​

This study used proteomics to identify markers of pancreatic β-cell dysfunction during prediabetes in humans. Researchers isolated islets from non-diabetic subjects undergoing partial pancreatectomy, characterized glucose tolerance and insulin function, then used laser capture microdissection (LCM) and HPLC-MS proteomic profiling to detect changes associated with impaired glucose tolerance (IGT). The key finding was that IGT islets showed reductions in proteins involved in glycolysis and lipid metabolism and other pathways relevant to β-cell dysfunction, suggesting candidate predictive biomarkers for diabetes onset.

Cefalo CMA, Mezza T, Quero G et al. · JCI insight · (2026) · View on PubMed ↗

Identification and Validation of miR-206-3p Targeting WT-1 Promotes Membranous Nephropathy Through a Comprehensive Bioinformatics and Machine Learning Algorithm.​

Using public datasets and bioinformatics/ML pipelines, this study identified microRNA-206-3p (miR-206-3p) as a regulator targeting WT-1 and then validated its role in membranous nephropathy (MN). miR-206-3p targeting of WT-1 promoted MN-associated pathology, supported by differential expression analyses and mechanistic validation. These results nominate the miR-206-3p/WT-1 axis as a potential therapeutic target and biomarker pathway for MN.

Wang X, Zhou F, Fu C et al. · FASEB journal : official publication of the Federation of American Societies for Experimental Biology · (2026) · View on PubMed ↗

Pulmonary Vascular Disease & Respiratory Critical Care​

Epidemiology, ventilation, and outcomes of acute respiratory failure in immunocompromised patients from 103 intensive care units in 26 countries: a retrospective observational study.​

This retrospective observational study characterized acute respiratory failure (ARF) in immunocompromised adults across 103 ICUs in 26 countries and assessed predictors of mortality and intubation. It found that contemporary epidemiology and management patterns vary internationally and that specific clinical factors related to underlying immunosuppression and ARF cause/oxygenation strategy are associated with outcomes (details truncated). The results provide evidence to improve risk prediction and ICU decision-making for immunocompromised patients with ARF.

Azoulay E, McEvoy C, Castro P et al. · The Lancet. Respiratory medicine · (2026) · View on PubMed ↗

Efficacy and Safety of Remimazolam Tosylate versus Propofol for Sedation of Postoperative Mechanically Ventilated Patients in Intensive Care Units: a Multicenter, Randomized, Single-blind, Non-inferiority, Phase 3 trial.​

The study compared remimazolam tosylate versus propofol for sedation in postoperative mechanically ventilated ICU patients in a multicenter, randomized, single-blind, non-inferiority phase 3 trial (NCT06222294). Patients were randomized to IV remimazolam tosylate (loading 0.08 mg/kg; maintenance 0–2.0 mg/kg/h) or propofol (loading 0.3–0.5 mg/kg; maintenance 0.3–4.0 mg/kg/h) targeting RASS -2 to 1. Demonstrating non-inferior safety/efficacy would support remimazolam as an alternative sedation strategy in mechanically ventilated postoperative patients.

Guan X, Liu N, Lin F et al. · Anesthesiology · (2026) · View on PubMed ↗

Musculoskeletal, Bone & Rehabilitation​

FGF21-Mediated Upregulation of SIRT1 Delays Intervertebral Disc Degeneration by Promoting PINK1/Parkin Dependent Mitophagy Through Deacetylation of FOXO3.​

This study examined whether FGF21-mediated upregulation of SIRT1 delays intervertebral disc degeneration by promoting PINK1/Parkin-dependent mitophagy through deacetylation of FOXO3, using human and rat degenerated intervertebral discs and in vitro assays. FGF21 was downregulated in degenerated discs, and restoring the FGF21–SIRT1 axis enhanced PINK1/Parkin mitophagy and reduced senescence-related pathology via FOXO3 deacetylation. These findings identify a FGF21–SIRT1–FOXO3–PINK1/Parkin pathway as a potential therapeutic target for slowing intervertebral disc degeneration.

Wu ZL, Ran R, Xie QQ et al. · Aging cell · (2026) · View on PubMed ↗

Velocity Loss During Resistance Training: Implications for Concurrent Training Adaptations.​

The study examined how different velocity loss (VL) thresholds during resistance training affect adaptations to concurrent training in 41 moderately trained men over 8 weeks. Concurrent training with VL thresholds of 0%, 15%, or 40% (plus endurance training) was compared with endurance training alone, focusing on strength, endurance, neuromuscular, and hypertrophic outcomes. The results inform how to set VL targets to optimize concurrent training adaptations without sacrificing key performance domains.

Tundidor-Duque RM, Loturco I, Paéz-Maldondado JA et al. · Scandinavian journal of medicine & science in sports · (2026) · View on PubMed ↗

Managing Bone Fragility in Older Adults with Diabetes: Pathophysiology, Assessment, and Therapeutic Considerations.​

This review summarized how diabetes in older adults (type 1 and type 2) contributes to bone fragility and fracture risk, focusing on differences in pathophysiology and implications for assessment and therapy. The key finding is that T1D-related fragility is often driven by reduced bone mineral density from insulinopenia, whereas T2D fragility can occur despite normal/high BMD due to impaired bone quality, microarchitecture changes, advanced glycation end products (AGEs), and low turnover. The clinical significance is improved fracture-risk stratification and more tailored therapeutic considerations for diabetic older adults.

Bahat G, Erdogan T, Ozturk S et al. · Drugs & aging · (2026) · View on PubMed ↗

Effects of Diactive-1-Supported Progressive Resistance Training on Body Composition in Youth With Type 1 Diabetes.​

This randomized/controlled exercise study evaluated the effects of Diactive-1–supported progressive resistance training on body composition in youth with type 1 diabetes (ages 8–18). Resistance training supported by the mHealth application improved specific body composition outcomes compared with baseline/controls. Clinically, it supports scalable digital-health–assisted resistance exercise as a strategy to counter diabetes-associated adverse body composition changes.

Muñoz-Pardeza J, López-Gil JF, Hormazábal-Aguayo I et al. · Journal of cachexia, sarcopenia and muscle · (2026) · View on PubMed ↗

Rare Diseases, Genetics & Translational Platforms​

Apoptotic extracellular vesicles derived from MSCs exposed to hypoxic and inflammatory environments slow intervertebral disc degeneration by enhancing cell activity and regulating immunity microenvironment.​

This preclinical study tested whether apoptotic extracellular vesicles (ApoEVs) derived from mesenchymal stem cells (MSCs) exposed to hypoxic and inflammatory conditions can slow intervertebral disc degeneration by enhancing nucleus pulposus cell activity and modulating the immune microenvironment. The authors reported that these MSC-derived ApoEVs improved disc degeneration phenotypes and regulated immune-related pathways in the degenerative context. The findings support ApoEV-based cell-free therapies as a strategy to overcome challenges of MSC survival and apoptosis in vivo.

Zhang W, Ma X, Yin H et al. · Materials today. Bio · (2026) · View on PubMed ↗

Cryo-EM structure of TRPM1 reveals a non-canonical architecture with an inverted transmembrane domain.​

This structural biology study examined the vision-related ion channel TRPM1 in the context of congenital stationary night blindness by isolating TRPM1 and determining its structure using cryogenic electron microscopy (cryo-EM). It found that TRPM1 forms a non-canonical architecture with an inverted transmembrane domain while maintaining a canonical tetrameric intracellular-domain fold consistent with other TRPM family members. This clarifies TRPM1’s molecular basis for ion-channel function and provides a structural framework for interpreting disease-causing mutations.

Fabrizio M, Brewer M, Bogdanović N et al. · Nature communications · (2026) · View on PubMed ↗

Transplantation of encapsulated mitochondria alleviates dysfunction in mitochondrial and Parkinson's disease models.​

The study tested a mitochondrial transplantation method in mice and monkeys by encapsulating mitochondria in vesicles derived from erythrocyte plasma membranes. Encapsulated mitochondria efficiently entered somatic tissues, complemented mitochondrial DNA loss/deletion/mutations, and rescued bioenergetic and biochemical defects in patient-derived mitochondrial disorder cells. These findings advance mitochondrial delivery as a potential therapeutic platform for mitochondrial diseases by improving exogenous mitochondrial uptake and functional restoration.

Du S, Long Q, Zhou Y et al. · Cell · (2026) · View on PubMed ↗

Resetting of a tandem microRNA156 enables vegetative perennial growth in rice.​

The study identified the genetic basis of perennial growth habit in rice by analyzing introgression lines of wild and cultivated rice. It mapped perennial growth to the EBT1 locus containing tandem microRNA156 genes (MIR156BC), showing that the wild allele (EBT1W1943) resets MIR156BC expression in tiller buds via altered chromatin accessibility and reduced H3K27me3. This advances understanding of microRNA-driven epigenetic regulation of vegetative propagation and floral reversion in crop domestication.

Dai B, Lv D, Chen E et al. · Science (New York, N.Y.) · (2026) · View on PubMed ↗

Phase separation of Rht8-derived RNHL1 integrates ethylene and gibberellin signaling to regulate wheat internode elongation.​

This study analyzed how the wheat semi-dwarfing gene Rht8, encoding RNHL1 (ribonuclease H-like 1), regulates internode elongation by integrating ethylene and gibberellin signaling. RNHL1 was shown to form nuclear liquid-liquid phase separation condensates via intrinsically disordered regions that interact with the ethylene signaling transcription factor TaEIL1 to create functional transcriptional hubs controlling growth. Scientifically, it reveals an LLPS-based transcriptional mechanism by which RNHL1 coordinates hormone crosstalk to shape plant architecture.

Dong C, Cheng X, Yuan M et al. · The Plant cell · (2026) · View on PubMed ↗

Stage-specific transcriptomics of a leader cell reveals cell machineries driving collective invasion.​

This study generated stage-specific transcriptomic data for the Caenorhabditis elegans gonadal leader cell, the distal tip cell (DTC), comparing invasive larval-stage DTCs with noninvasive adult-stage DTCs. The resulting in vivo signature revealed molecular programs and cell-invasion “machineries” that drive collective invasion. The dataset provides a mechanistic framework for how leader cells coordinate invasion, informing broader understanding of development and metastasis.

Agarwal P, Maimon Zielonka I, Gingold H et al. · The Journal of cell biology · (2026) · View on PubMed ↗

ECM1 produced by hepatic stellate cells serves as gate keeper of liver homeostasis in hepatic fibrosis.​

Using inducible hepatic stellate cell (HSC) ablation in Lrat-iDTR mice and multi-parametric analyses across two fibrosis models (CCl4-driven injury and MASH induced by choline-deficient high-fat diet, CD-HFD), this study examined how HSC homeostatic functions relate to fibrosis. The authors identified ECM1 produced by hepatic stellate cells as a “gatekeeper” of liver homeostasis during hepatic fibrosis. Targeting ECM1 could preserve beneficial HSC homeostatic activity while limiting fibrogenic progression.

Yang A, Yan X, Wang Y et al. · Hepatology (Baltimore, Md.) · (2026) · View on PubMed ↗

Onasemnogene Abeparvovec in Type I Spinal Muscular Atrophy: 24-Month Follow-Up From the Italian Registry.​

This 24-month prospective observational study from the Italian registry followed spinal muscular atrophy type I (SMA I) patients treated with onasemnogene abeparvovec (AAV9 gene therapy). Outcomes were characterized in real-world practice, including how patients were categorized by treatment status (monotherapy vs bridge from nusinersen/risdiplam vs switch after >3 months). Longer-term registry data are clinically important for counseling families and understanding response variability beyond trial timeframes.

Pane M, Coratti G, Cutrì C et al. · Annals of clinical and translational neurology · (2026) · View on PubMed ↗

A Rare RIPK3 Variant Enhances Necroptosis and Promotes Inflammation in a Still's Disease-like Autoinflammatory Syndrome.​

In a three-generation family with a Still’s disease–like autoinflammatory syndrome, this study used whole-exome sequencing to identify a rare RIPK3 variant (p.Q134K) and then performed functional assays. The RIPK3 p.Q134K variant enhanced kinase activity, increased necroptosis, and promoted inflammatory signaling, supported by peripheral blood transcriptomic profiling. This links a specific RIPK3 genetic change to disease mechanism, informing precision diagnosis and potential necroptosis-targeted therapies.

Chen L, Dai Q, Xiao Y et al. · Arthritis & rheumatology (Hoboken, N.J.) · (2026) · View on PubMed ↗

Generated automatically on March 21, 2026 from PubMed's trending articles. Summaries are AI-generated; always consult the original publication for clinical or research decisions.

Automated digest · 99 articles · 15 research areas · March 21, 2026

Overview​

This week's trending research highlights significant advancements across various biomedical fields, particularly in oncology, neurology, and metabolic disease. Notable studies include the development of targeted therapies for cancer, such as the ERAD-engaging chimeras for degrading PD-L1 and the bispecific nanobody-drug conjugate for pancreatic cancer, which could enhance treatment efficacy. Additionally, research into the role of gut microbiota in neuropsychiatric disorders and the implications of dietary patterns on neuroinflammation underscores the growing recognition of the microbiome's impact on health. Overall, these findings reflect the dynamic nature of current biomedical research, emphasizing the integration of novel technologies and interdisciplinary approaches to address complex health challenges.

Neurology​

Effect of a clinical decision support system on stroke care quality and outcomes in patients with acute ischaemic stroke (GOLDEN BRIDGE II): cluster randomised clinical trial.​

This study evaluated the efficacy of a clinical decision support system (CDSS) on stroke care quality and outcomes among 21,603 patients with acute ischaemic stroke across 77 hospitals in China. The implementation of CDSS significantly improved stroke care quality and clinical outcomes compared to standard care. This finding suggests that integrating AI-assisted tools in clinical settings could enhance patient management and outcomes in acute stroke care.

Zhang X, Ding L, Jing J et al. · BMJ (Clinical research ed.) · (2026) · View on PubMed ↗

Tavapadon as Adjunctive Treatment for Parkinson Disease: The TEMPO-3 Randomized Clinical Trial.​

The TEMPO-3 trial evaluated the efficacy and safety of tavapadon, a selective D1/D5 agonist, as adjunctive treatment for Parkinson's disease patients experiencing motor fluctuations. Tavapadon significantly improved motor control while minimizing adverse events compared to traditional D2/D3 agonists. This highlights the potential for D1/D5 agonists to offer safer therapeutic options for managing Parkinson's disease.

Fernandez HH, Isaacson SH, Hauser RA et al. · JAMA neurology · (2026) · View on PubMed ↗

Mitoxyperilysis: fasting-induced cell death in immunometabolism and disease.​

This study developed a predictive atlas using retinal fundus photographs to assess disease onset risk across various conditions. The findings indicate that retinal imaging could serve as a non-invasive tool for early disease detection. This approach may enhance preventive healthcare strategies by identifying at-risk individuals.

Al-Zidan R, Gautam M, Man SM · Trends in biochemical sciences · (2026) · View on PubMed ↗

Transplantation of encapsulated mitochondria alleviates dysfunction in mitochondrial and Parkinson's disease models.​

This research evaluated the transplantation of encapsulated mitochondria in models of mitochondrial dysfunction and Parkinson's disease. The findings indicated that this approach effectively alleviated dysfunction and restored bioenergetic properties. This could represent a novel therapeutic strategy for mitochondrial diseases.

Du S, Long Q, Zhou Y et al. · Cell · (2026) · View on PubMed ↗

International Expert Opinion on Optimal Switching to Cladribine Tablets from Other High-Efficacy Disease-Modifying Therapies for Relapsing-Remitting Multiple Sclerosis: Opportunities and Challenges.​

This expert opinion discusses optimal switching strategies to cladribine tablets for multiple sclerosis patients previously treated with high-efficacy therapies. The recommendations aim to improve treatment outcomes and patient management. This highlights the need for evidence-based guidelines in multiple sclerosis care.

Chan A, Alroughani R, Calabrese M et al. · Neurology and therapy · (2026) · View on PubMed ↗

Transradial vs Transfemoral Access for Cerebral Angiography: A Randomized Noninferiority Clinical Trial.​

This randomized trial compared transradial access to transfemoral access for cerebral angiography, finding that transradial access is a safe and effective alternative. The results suggest that TRA could enhance patient comfort and reduce complications. This research could influence procedural practices in neurointerventional radiology.

Ni W, Yang H, Su J et al. · JAMA network open · (2026) · View on PubMed ↗

Women with epilepsy: Evidence-based counseling across the lifespan.​

This review discusses the unique challenges faced by women with epilepsy across their lifespan, emphasizing the need for tailored clinical management. The findings highlight gaps in care and the importance of integrating sex-specific considerations into epilepsy treatment. This research aims to enhance the quality of care for women with epilepsy.

Tettenborn B, Ramantani G, Flügel D et al. · Epilepsia · (2026) · View on PubMed ↗

Onasemnogene Abeparvovec in Type I Spinal Muscular Atrophy: 24-Month Follow-Up From the Italian Registry.​

This study evaluated the long-term outcomes of onasemnogene abeparvovec in type I spinal muscular atrophy, providing valuable real-world data. The findings indicate that this gene therapy is effective in improving patient outcomes over 24 months. This research contributes to the understanding of gene therapy in neuromuscular disorders.

Pane M, Coratti G, Cutrì C et al. · Annals of clinical and translational neurology · (2026) · View on PubMed ↗

Oncology​

Hijacking ERAD for targeted degradation of transmembrane proteins.​

The researchers developed a targeted protein degradation technology called ERAD-engaging chimeras (ERADECs) to efficiently degrade transmembrane proteins, specifically targeting programmed death-ligand 1 (PD-L1). They demonstrated that this approach could effectively reduce PD-L1 levels, which is significant for cancer immunotherapy. This technology could pave the way for novel therapeutic strategies in targeting difficult-to-degrade proteins in various diseases.

Song H, Wang W, Mei T et al. · Cell · (2026) · View on PubMed ↗

Lactylation Converts ABHD6 into a Mitochondrial Regulator that Drives Lenvatinib Resistance in Hepatocellular Carcinoma.​

The study identified that lactylation converts ABHD6 into a mitochondrial regulator that drives resistance to lenvatinib in hepatocellular carcinoma (HCC). The research found that ABHD6's non-canonical scaffolding function, rather than its enzymatic activity, contributed to this resistance. This insight into the metabolic adaptations in HCC could inform new therapeutic strategies to overcome drug resistance.

Sun Y, Luo C, Yang H et al. · Cancer research · (2026) · View on PubMed ↗

Trends in 5-year net survival for women diagnosed with breast, cervical or ovarian cancer in Japan, 2000-14 (CONCORD-3).​

The study analyzed long-term survival trends for women diagnosed with breast, cervical, or ovarian cancer in Japan from 2000 to 2014 using data from the CONCORD-3 project. The findings indicated improvements in five-year net survival rates for these cancers over the study period. This highlights progress in cancer treatment and early detection efforts in Japan.

Watanabe K, Di Carlo V, Sugiyama H et al. · Japanese journal of clinical oncology · (2026) · View on PubMed ↗

Targeting tumor-associated macrophages-induced IGF1/PI3K/Zic1 axis triggers SHH medulloblastoma regression and chemosensitization.​

The study investigated the role of tumor-associated macrophages in medulloblastoma progression and chemoresistance by targeting the IGF1/PI3K/Zic1 axis. The findings suggest that inhibiting this axis can trigger tumor regression and enhance chemotherapy sensitivity. This approach could lead to improved treatment strategies for medulloblastoma.

Pang YC, Wang C, Qiu JF et al. · Neuro-oncology · (2026) · View on PubMed ↗

Liquid biopsy for the diagnosis of EBV-positive Burkitt's lymphoma in endemic areas.​

The study evaluated the diagnostic accuracy of liquid biopsies for EBV-positive Burkitt's lymphoma in endemic areas, demonstrating their potential for rapid diagnosis. The use of circulating tumor DNA markers improved diagnostic turnaround time compared to traditional methods. This approach could enhance early detection and treatment of Burkitt's lymphoma in resource-limited settings.

Chamba C, Christopher H, Josephat E et al. · Nature medicine · (2026) · View on PubMed ↗

Extrachromosomal DNA in urothelial carcinoma: mechanisms and clinical applications.​

The review discusses the mechanisms and clinical applications of extrachromosomal DNA (ecDNA) in urothelial carcinoma, highlighting its role in genomic instability and tumor evolution. The detection of ecDNA through non-invasive liquid biopsies offers potential for early diagnosis and monitoring. Understanding ecDNA biology could lead to novel therapeutic strategies for urothelial carcinoma.

Li C, Hu Z, Zhang W et al. · Nature reviews. Urology · (2026) · View on PubMed ↗

Targeting WIP1 reprograms immunosuppressive tumor microenvironment to potentiate immunotherapy response in colorectal cancer.​

This study identified WIP1 as a critical immunosuppressive driver in colorectal cancer, with its inhibition enhancing anti-tumor immune responses. The research demonstrated that targeting WIP1 remodels the tumor immune microenvironment, increasing macrophage and T cell infiltration. This suggests that WIP1 inhibition could improve the efficacy of immunotherapy in colorectal cancer.

Chen L, Chen M, Yuan S et al. · Cell death and differentiation · (2026) · View on PubMed ↗

SHR-A1811, a novel HER2-targeting antibody-drug conjugate, in advanced solid tumors (HORIZON-X): a global phase 1 trial.​

The HORIZON-X trial evaluated SHR-A1811, a novel HER2-targeting antibody-drug conjugate, in patients with advanced solid tumors. The results showed substantial antitumor activity, indicating its potential as a treatment option for HER2-expressing tumors. This study highlights the promise of targeted therapies in oncology.

Yao H, Yan M, Tong Z et al. · Signal transduction and targeted therapy · (2026) · View on PubMed ↗

A predictive atlas of disease onset from retinal fundus photographs: a modelling study using data from population-based cohorts.​

This systematic review and meta-analysis evaluated the prognostic significance of microsatellite instability (MSI), PD-L1 expression, and Epstein-Barr virus (EBV) positivity in gastric cancer. The findings suggest that these biomarkers are important for treatment selection and prognosis in gastric cancer patients. This underscores the need for personalized approaches in gastric cancer management.

Buergel T, Loock L, Steinfeldt J et al. · The Lancet. Digital health · (2026) · View on PubMed ↗

Risk Assessment in Large B-Cell Lymphoma Using Metabolic Tumor Volume: Real-World Data from a Multicenter Cohort of Patients Undergoing CAR T-Cell Therapy.​

This study assessed the use of metabolic tumor volume (MTV) as a risk assessment tool in large B-cell lymphoma patients undergoing CAR T-cell therapy. The findings suggest that MTV may provide better prognostic information than traditional methods. This could improve patient stratification and treatment outcomes in lymphoma therapy.

Voltin CA, Flossdorf S, Kurch L et al. · Journal of nuclear medicine : official publication, Society of Nuclear Medicine · (2026) · View on PubMed ↗

Hypoxia-related and immune phenotype-related fusion model for non-invasive prognostication of hepatocellular carcinoma treated by TACE: a multicentre study.​

The study developed a hypoxia-related and immune phenotype-related fusion model for prognostication in hepatocellular carcinoma treated with transarterial chemoembolization (TACE). The model demonstrated improved predictive accuracy for patient survival outcomes. This could enhance clinical decision-making in HCC management.

Guo Y, Zhang G, Fu X et al. · Gut · (2026) · View on PubMed ↗

CAV1-DOT1L axis in TAM-derived EVs orchestrates VM and sensitises PDAC to combined VM and VEGF targeting.​

This research explored the role of the CAV1-DOT1L axis in tumor-associated macrophages and its impact on vasculogenic mimicry in pancreatic ductal adenocarcinoma (PDAC). The findings suggest that targeting this axis could sensitize PDAC to combined therapies. This highlights potential therapeutic strategies for overcoming resistance in pancreatic cancer.

Liu Z, Zhang Y, Wu H et al. · Gut · (2026) · View on PubMed ↗

A bispecific nanobody-drug conjugate targeting TROP2 and c-Met for low-concentration, single-dose treatment of pancreatic cancer.​

This study introduced a bispecific nanobody-drug conjugate targeting TROP2 and c-Met for treating pancreatic cancer. Preclinical results demonstrated potent cytotoxicity and superior tumor inhibition compared to existing therapies. This suggests a promising new direction for targeted cancer treatments.

Ning W, Liu H, Zeng H et al. · Cell reports. Medicine · (2026) · View on PubMed ↗

Preferences in Cyclin-Dependent Kinase 4/6 Inhibitors for Advanced Breast Cancer Among Medical Oncologists in Latin America.​

This cross-sectional survey examined preferences for cyclin-dependent kinase 4/6 inhibitors among medical oncologists in Latin America treating advanced breast cancer. The results showed a preference for ribociclib, influenced by availability and clinical scenarios. This highlights the need for better access to effective therapies in the region.

Villarreal-Garza C, Meraz-Brenez A, Reyes Morales A et al. · JCO global oncology · (2026) · View on PubMed ↗

Overcoming T cell tolerance to tumor self-antigens through catch-bond engineering.​

The study developed a method to engineer T cells to overcome tolerance to tumor self-antigens, enhancing their anti-tumor activity. The findings indicate that catch-bond engineering can improve T cell responses against tumors. This approach could lead to more effective immunotherapies for cancer.

Chen X, Mao Z, Kolawole EM et al. · Science (New York, N.Y.) · (2026) · View on PubMed ↗

A CHKA-PML autophagy checkpoint enables tumors to evade glutamine starvation.​

The study identified a CHKA-PML autophagy checkpoint that enables tumors to evade glutamine starvation. The findings suggest that targeting this checkpoint could enhance the efficacy of cancer therapies. This research highlights the adaptive mechanisms tumors use to survive metabolic stress.

Wang R, Cao L, He X et al. · Proceedings of the National Academy of Sciences of the United States of America · (2026) · View on PubMed ↗

Post hoc estimation of a quantitative restriction spectrum imaging biomarker for prostate cancer detection using conventional MRI.​

This study evaluated the diagnostic performance of restriction spectrum imaging for prostate cancer detection using conventional MRI. The findings suggest that this technique improves detection accuracy for clinically significant prostate cancer. This could enhance diagnostic capabilities in prostate cancer management.

Do DD, Conlin CC, Bagrodia A et al. · Journal of applied clinical medical physics · (2026) · View on PubMed ↗

Unveiling the multifaceted roles of BCL3: biological functions and disease implications.​

This review outlines the multifaceted roles of BCL3 in cancer biology, including its regulatory functions in the NF-κB signaling pathway. The findings suggest that BCL3 may serve as a potential therapeutic target in various malignancies. This research contributes to the understanding of oncogenic mechanisms.

Guo X, Guo R, Wang W et al. · Apoptosis : an international journal on programmed cell death · (2026) · View on PubMed ↗

Long-term outcomes of eribulin‑based neoadjuvant chemotherapy for triple‑negative breast cancer patients stratified by homologous recombination deficiency status: results of the randomized JBCRG-22 study.​

This study evaluated long-term outcomes of eribulin-based neoadjuvant chemotherapy in triple-negative breast cancer patients based on homologous recombination deficiency status. The findings suggest that HRD status may influence treatment efficacy and patient outcomes. This research could inform personalized treatment strategies in breast cancer.

Masuda N, Yasojima H, Bando H et al. · Breast cancer research and treatment · (2026) · View on PubMed ↗

The therapeutic potential of Piezo1 channel-mediated ferroptosis and its inhibitor.​

This study explored the therapeutic potential of Piezo1 channel-mediated ferroptosis in cancer treatment. The findings suggest that targeting Piezo1 could enhance ferroptosis and improve cancer therapy outcomes. This research highlights the importance of understanding cell death mechanisms in cancer treatment.

Nan K, Zhang L, Zhao Y et al. · Apoptosis : an international journal on programmed cell death · (2026) · View on PubMed ↗

Gsα deficiency in macrophages promotes tumor progression via the MAPK signaling pathway.​

This study examined the role of Gsα deficiency in macrophages and its impact on tumor progression via the MAPK signaling pathway. The findings indicate that Gsα deficiency accelerates tumor growth and metastasis. This research suggests that targeting Gsα could be a potential strategy for cancer immunotherapy.

Yan W, Yang J, Tan S et al. · Journal of molecular medicine (Berlin, Germany) · (2026) · View on PubMed ↗

Bireociclib Plus Fulvestrant in Advanced Breast Cancer After Endocrine Progression: The BRIGHT-2 Phase 3 Randomized Clinical Trial.​

This phase 3 trial evaluated the efficacy of bireociclib plus fulvestrant in advanced breast cancer after endocrine therapy progression. The findings demonstrated significant improvements in treatment outcomes, suggesting this combination could be a viable option for patients. This research contributes to the evolving landscape of breast cancer therapy.

Wang J, Zhang Q, Li H et al. · JAMA oncology · (2026) · View on PubMed ↗

Diagnostic Performance of Anti-Epstein-Barr Virus BNLF2b in Suspected Nasopharyngeal Carcinoma.​

This study assessed the diagnostic performance of anti-EBV BNLF2b in suspected nasopharyngeal carcinoma, finding it to be a reliable biomarker. The results suggest that this assay could improve early detection and reduce misdiagnosis rates. This research highlights the importance of accurate biomarkers in cancer diagnostics.

Li SC, Li FG, Wu SJ et al. · JAMA oncology · (2026) · View on PubMed ↗

HTRA1+ macrophages induce T cells egress through CRIP1/NF-κB/CXCL12 to limit the effects of immunotherapy in triple-negative breast cancer.​

The study examined the role of HTRA1+ macrophages in triple-negative breast cancer, revealing their involvement in T cell egress and immunotherapy response. The findings suggest that targeting these macrophages could enhance immunotherapy efficacy. This research underscores the importance of understanding tumor-immune interactions in cancer treatment.

Weng J, Xu W, Wang F et al. · Cancer immunology research · (2026) · View on PubMed ↗

Stage-specific transcriptomics of a leader cell reveals cell machineries driving collective invasion.​

This study investigated the stage-specific transcriptomics of leader cells in collective invasion, providing insights into the molecular mechanisms driving this process. The findings suggest that specific gene expression profiles are crucial for leader cell functions during invasion. This research could inform strategies to target cancer metastasis.

Agarwal P, Maimon Zielonka I, Gingold H et al. · The Journal of cell biology · (2026) · View on PubMed ↗

Use of ctDNA in Older Women with ER+ Breast Cancer to Facilitate Surgical De-escalation: A Prospective, Hybrid-Decentralized Trial with Correlative Studies.​

This prospective trial evaluated the use of circulating tumor DNA in older women with ER+ breast cancer to facilitate surgical de-escalation. The findings suggest that ctDNA levels could guide treatment decisions and improve patient outcomes. This research highlights the potential for personalized approaches in breast cancer management.

Carleton N, Chang AC, Chen F et al. · Clinical cancer research : an official journal of the American Association for Cancer Research · (2026) · View on PubMed ↗

Albumin-Bound STING Agonist Reprograms HSPCs to Antitumor Neutrophils Enhancing CD8+ T Cell Immunity.​

This study investigated the effects of an albumin-bound STING agonist on reprogramming hematopoietic stem and progenitor cells to enhance antitumor immunity. The findings suggest that this approach could improve responses to immunotherapy. This research highlights the potential for innovative strategies in cancer treatment.

Tao J, Zhao HY, Li C et al. · Advanced science (Weinheim, Baden-Wurttemberg, Germany) · (2026) · View on PubMed ↗

PMID 41854222​

This study explored the role of phospholipid glutathione peroxidase in mitigating cancer cachexia by protecting muscle mass and reducing inflammation. The findings suggest that targeting oxidative stress could be a therapeutic strategy for cancer cachexia. This research underscores the importance of addressing muscle health in cancer patients.

View on PubMed ↗

Regulation of YAP activity by nuclear G-actin binding.​

This study investigated the regulation of YAP activity by nuclear G-actin binding, revealing its role in cellular processes. The findings suggest that G-actin binding modulates YAP's transcriptional activity. This research contributes to understanding the mechanistic pathways involved in cell growth and cancer.

Wang H, Jayawardana IM, Fleisch JM et al. · Nucleic acids research · (2026) · View on PubMed ↗

Cardiovascular Medicine​

USP25 regulates atherosclerosis by restricting RIPK1-mediated inflammatory responses.​

This study investigated the role of the deubiquitinating enzyme USP25 in atherosclerosis using mouse models and human atherosclerotic lesions. The findings revealed that USP25 is downregulated in atherosclerotic lesions and its expression is crucial for regulating inflammatory responses mediated by RIPK1. This suggests that targeting USP25 could be a potential therapeutic strategy for managing atherosclerosis and its associated inflammatory processes.

Su X, Zhou B, Xu Y et al. · EBioMedicine · (2026) · View on PubMed ↗

Prognostic Impact of Elevated Pulmonary Vascular Resistance in Group 2 Pulmonary Hypertension: Insights From a Japanese Multicenter Registry.​

This study assessed the prognostic impact of elevated pulmonary vascular resistance in patients with Group 2 pulmonary hypertension using data from two Japanese multicenter registries. The analysis revealed that higher pulmonary vascular resistance was associated with worse outcomes, including increased hospitalization and mortality. These findings underscore the importance of monitoring pulmonary vascular resistance in managing patients with pulmonary hypertension.

Satoh T, Sugimura K, Fukumoto Y et al. · Journal of the American Heart Association · (2026) · View on PubMed ↗

Stroke Risk After Bioprosthetic Aortic Valve Replacement in Aortic Stenosis: Systematic Review and Meta-Analysis.​

This systematic review and meta-analysis examined the incidence of stroke following bioprosthetic aortic valve replacement in patients with aortic stenosis. The study found a significant proportion of patients experienced ischemic stroke within the periprocedural period. These insights are crucial for improving patient management and risk stratification in cardiac surgery.

Bou Dargham T, Hassani S, Mac Grory BC et al. · Stroke · (2026) · View on PubMed ↗

Inhibiting RhoA Activation Via GDP-State Stabilization to Relieve Heart Failure.​

The study investigated the inhibition of RhoA activation as a potential therapeutic strategy for heart failure by stabilizing its GDP-bound state. The findings suggest that targeting RhoA could mitigate pathological myocardial remodeling and improve heart function. This approach may represent a novel avenue for heart failure treatment.

Xue M, Liang Y, Yuan Z et al. · Circulation research · (2026) · View on PubMed ↗

Fibrinogen-Bmal1 signaling as a therapeutic target to limit aortic dissection by preserving VSMC contractility.​

The study explored fibrinogen-Bmal1 signaling as a therapeutic target to limit aortic dissection by preserving vascular smooth muscle cell contractility. The findings suggest that higher plasma fibrinogen levels are associated with better clinical outcomes in aortic dissection patients. This could inform new treatment strategies for managing aortic dissection.

Zhong X, Li D, Zhao Y et al. · Signal transduction and targeted therapy · (2026) · View on PubMed ↗

Integration of Epidemiology and Network Toxicology Revealed the Arrhythmogenic Potential of Neonicotinoid Insecticides.​

The study assessed the arrhythmogenic potential of neonicotinoid insecticides using epidemiological and network toxicology approaches. Findings indicated that exposure to neonicotinoids was associated with increased arrhythmia risk in patients. This raises concerns about the safety of these widely used insecticides and their potential health impacts.

Ge Y, Xiao Q, Fu B et al. · Environmental science & technology · (2026) · View on PubMed ↗

Immunology​

Postural Orthostatic Tachycardia Syndrome, Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Long COVID as Neuroimmune Disorders.​

This article explores the neuroimmune mechanisms underlying Postural Orthostatic Tachycardia Syndrome (POTS), myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), and Long COVID. The study identifies common pathophysiological factors such as autonomic dysfunction and immune dysregulation. Understanding these connections may inform treatment approaches for these overlapping disorders.

Blitshteyn S, Doherty TA, Steinman L · ImmunoTargets and therapy · (2026) · View on PubMed ↗

PMID 41856896​

The review discusses mitoxyperilysis, a novel cell death mechanism linked to immunometabolism and disease, particularly in sepsis and cancer. This unique form of cell death is triggered by immune agonists combined with fasting, suggesting potential therapeutic implications. Understanding this process could lead to innovative treatment strategies in critical care.

View on PubMed ↗

Anifrolumab in systemic lupus erythematosus: real-world evidence from a Spanish multicentre cohort of 206 patients and literature review.​

This study evaluated the real-world effectiveness of anifrolumab in patients with systemic lupus erythematosus (SLE) across multiple centers in Spain. The findings indicate that anifrolumab is effective and well-tolerated in clinical practice. This adds to the growing body of evidence supporting the use of anifrolumab in SLE management.

Calvo-Río V, Secada-Gómez C, Martín Gutiérrez A et al. · RMD open · (2026) · View on PubMed ↗

Quantifying immune dysregulation in pneumonia and sepsis with a parsimonious machine-learning model: a multicohort analysis across care settings and reanalysis of a hydrocortisone randomised controlled trial.​

The study developed a machine-learning model to quantify immune dysregulation in pneumonia and sepsis, aiming to improve prognostication and treatment responses. The model showed promise in identifying patients who may benefit from immunomodulation therapies. This approach could enhance personalized medicine strategies in critical care.

Michels EHA, Dequin PF, Butler JM et al. · The Lancet. Respiratory medicine · (2026) · View on PubMed ↗

A Rare RIPK3 Variant Enhances Necroptosis and Promotes Inflammation in a Still's Disease-like Autoinflammatory Syndrome.​

This study identified a rare RIPK3 variant that enhances necroptosis and promotes inflammation in a Still's disease-like autoinflammatory syndrome. The findings suggest that this variant plays a role in the pathogenesis of autoinflammatory diseases. This research could inform genetic screening and therapeutic strategies for these conditions.

Chen L, Dai Q, Xiao Y et al. · Arthritis & rheumatology (Hoboken, N.J.) · (2026) · View on PubMed ↗

Metabolic Disease​

Joint TOS/OMA/OAC expert guidance statement on the pharmacological management of United States adults with overweight or obesity using the GRADE approach.​

This expert guidance statement provides updated pharmacological management recommendations for adults with overweight or obesity in the United States. It highlights the importance of evidence-based treatments and addresses barriers to obesity management. The recommendations aim to improve access to effective obesity treatments and reduce related health complications.

Alexander L, Purnell JQ, Burridge K et al. · Obesity pillars · (2026) · View on PubMed ↗

Skeletal muscle metabolism in health and disease: Mechanisms, interventions, and clinical perspectives.​

This review synthesizes the mechanisms, interventions, and clinical perspectives related to skeletal muscle metabolism in health and disease. It highlights the role of metabolic flexibility in preventing metabolic diseases and discusses key regulators of muscle metabolism. Understanding these processes is crucial for developing strategies to combat conditions like obesity and sarcopenia.

Lin D, Zhang L, Huang C et al. · iScience · (2026) · View on PubMed ↗

Type 2 diabetes mellitus.​

This review provides a comprehensive overview of type 2 diabetes mellitus, discussing its epidemiology, risk factors, and complications. The rising prevalence of early-onset type 2 diabetes is highlighted, emphasizing the need for targeted interventions. Understanding the complexities of T2DM is crucial for developing effective prevention and management strategies.

Davies MJ, Lim S, Slater T et al. · Nature reviews. Disease primers · (2026) · View on PubMed ↗

Adherence to the EAT-Lancet Diet and Risk of Sepsis: A Prospective Cohort Study from the UK Biobank.​

This prospective cohort study examined the association between adherence to the EAT-Lancet diet and sepsis risk in a large UK Biobank population. The results indicated that higher adherence to this diet was linked to a significantly reduced risk of sepsis. This suggests that dietary interventions could play a role in sepsis prevention.

Nan W, Huang Q, He B et al. · NPJ science of food · (2026) · View on PubMed ↗

Velocity Loss During Resistance Training: Implications for Concurrent Training Adaptations.​

This study investigated the effects of different velocity loss thresholds during resistance training on body composition in youth with type 1 diabetes. The results indicated that specific thresholds could optimize training outcomes, improving body composition. This research could inform exercise recommendations for this population.

Tundidor-Duque RM, Loturco I, Paéz-Maldondado JA et al. · Scandinavian journal of medicine & science in sports · (2026) · View on PubMed ↗

The relationship between sarcopenia and all-cause and cardiovascular mortality risk among middle-aged and older adults across stages 0-3 of cardiovascular-kidney-metabolic syndrome: evidence from NHANES and CHARLS.​

This study examined the relationship between sarcopenia and mortality risk among middle-aged and older adults across stages of cardiovascular-kidney-metabolic syndrome. The findings indicated that sarcopenia is associated with increased mortality risk, emphasizing the need for early identification and intervention. This highlights the importance of muscle health in aging populations.

Chen Y, Liu Y, Liu S et al. · Cardiorenal medicine · (2026) · View on PubMed ↗

Gut microbe-derived N-acyl serinol lipids shape host postprandial metabolic homeostasis.​

This study investigated the role of gut microbe-derived N-acyl serinol lipids in postprandial metabolic homeostasis. The findings suggest that these metabolites play a significant role in regulating metabolic responses to food. This could inform dietary interventions aimed at improving metabolic health.

Dutta S, Mahen KK, Massey WJ et al. · Proceedings of the National Academy of Sciences of the United States of America · (2026) · View on PubMed ↗

MASLD as a systemic metabolic disease: expanding the scope of cardiovascular-kidney-metabolic (CKM) syndrome.​

This review discusses metabolic dysfunction-associated steatotic liver disease (MASLD) and its systemic impacts on cardiovascular and renal health. The findings emphasize the need for integrated management of MASLD in cardiology and nephrology. This highlights the importance of recognizing MASLD as a systemic metabolic disease.

Zhou XD, Fan QY, Targher G et al. · Science China. Life sciences · (2026) · View on PubMed ↗

Managing Bone Fragility in Older Adults with Diabetes: Pathophysiology, Assessment, and Therapeutic Considerations.​

This review discusses the management of bone fragility in older adults with diabetes, highlighting the distinct pathophysiological mechanisms involved. The findings emphasize the need for tailored assessment and treatment strategies for this population. This research underscores the importance of addressing bone health in diabetes management.

Bahat G, Erdogan T, Ozturk S et al. · Drugs & aging · (2026) · View on PubMed ↗

Effects of Diactive-1-Supported Progressive Resistance Training on Body Composition in Youth With Type 1 Diabetes.​

This study examined the effects of progressive resistance training on body composition in youth with type 1 diabetes, finding positive outcomes. The findings suggest that resistance training can improve body composition in this population. This research could inform exercise recommendations for managing diabetes in children and adolescents.

Muñoz-Pardeza J, López-Gil JF, Hormazábal-Aguayo I et al. · Journal of cachexia, sarcopenia and muscle · (2026) · View on PubMed ↗

Genomics & Genetics​

Embedded CRISPRi Enhances Gene-Silencing Efficiency in Drosophila.​

This research introduced embedded CRISPR interference (emCRISPRi) to enhance gene-silencing efficiency in Drosophila by integrating transcriptional repression domains into dCas9. The emCRISPRi platform significantly improved the silencing of coding genes and cis-regulatory elements. This advancement could facilitate more precise genetic studies and applications in developmental biology.

Fu P, Zhang X, Zhou Y et al. · Advanced science (Weinheim, Baden-Wurttemberg, Germany) · (2026) · View on PubMed ↗

Human DHX29 detects nonoptimal codon usage to regulate mRNA stability.​

This study identified DHX29 as a regulator of mRNA stability linked to nonoptimal codon usage in human cells. The findings suggest that DHX29 plays a critical role in gene expression regulation. This could have implications for understanding translational control in various diseases.

Hia F, Wu Y, Yoshinaga M et al. · Science (New York, N.Y.) · (2026) · View on PubMed ↗

Unstructured transcription factor interactions enable emergent specificity.​

The research explored how unstructured transcription factor interactions influence gene specificity and chromatin organization. The findings suggest that intrinsically disordered regions can enhance transcription factor binding to chromatin. This could inform our understanding of gene regulation mechanisms.

Abidi AA, Cattoglio C, Tang NN et al. · Science (New York, N.Y.) · (2026) · View on PubMed ↗

Neuroscience​

How gut microbiota contribute to neuropsychiatric disorders: evidence from neuroimaging studies.​

The review discusses the contribution of gut microbiota to neuropsychiatric disorders, emphasizing the microbiota-gut-brain axis. Neuroimaging studies reveal associations between gut microbial alterations and brain structure/function abnormalities. This highlights the potential for microbiome-targeted interventions in treating neuropsychiatric conditions.

Jia C, Zhu W, Yuan Y et al. · Frontiers in microbiology · (2026) · View on PubMed ↗

Cryo-EM structure of TRPM1 reveals a non-canonical architecture with an inverted transmembrane domain.​

The study utilized cryo-EM to determine the structure of TRPM1, revealing a non-canonical architecture that could inform its function in vision. The findings suggest that TRPM1's structure may contribute to its role in light sensitivity and retinal signaling. Understanding TRPM1's structure could aid in developing therapies for vision-related disorders.

Fabrizio M, Brewer M, Bogdanović N et al. · Nature communications · (2026) · View on PubMed ↗

Hypothalamic clock governs circadian pain.​

This study found that the hypothalamic clock regulates circadian pain sensitivity, with implications for chronic pain management. The research demonstrated that daily oscillations in pain thresholds are linked to hypothalamic signaling pathways. This could inform new approaches to pain treatment based on circadian rhythms.

Wei HR, Lou Q, Li LX et al. · Science (New York, N.Y.) · (2026) · View on PubMed ↗

From chronic pain to depression: Neurogenesis-driven microglial remodeling in the hippocampal dentate gyrus.​

This research explored the link between chronic pain and depression, identifying neurogenesis-driven microglial remodeling in the hippocampus. The findings suggest that pain-induced changes in the hippocampus may contribute to affective disorders. This highlights the need for integrated approaches to pain and mental health treatment.

Ding M, Xiang S, Zhang Y et al. · Science (New York, N.Y.) · (2026) · View on PubMed ↗

Astrocytes at the crossroads of obstructive sleep apnea and Alzheimer's disease: from oxygen sensing to neurodegeneration.​

The review discusses the role of astrocytes in linking obstructive sleep apnea and Alzheimer's disease, highlighting their potential as therapeutic targets. The findings suggest that astrocytes may mediate the effects of sleep disturbances on neurodegeneration. This research underscores the importance of addressing sleep disorders in Alzheimer's disease management.

Cabot J, Soriano JB, Alonso-Fernández A et al. · Sleep & breathing = Schlaf & Atmung · (2026) · View on PubMed ↗

Interplay of oxidative stress and neuroinflammation in alzheimer's: insights into age-driven pathogenesis.​

This review explores the interplay of oxidative stress and neuroinflammation in Alzheimer's disease, focusing on age-driven pathogenesis. The findings suggest that targeting oxidative stress could be a therapeutic strategy for AD. This research highlights the complex mechanisms underlying neurodegeneration.

Firdous SM, Chakrabortty S, Undale VR et al. · Inflammopharmacology · (2026) · View on PubMed ↗

Therapeutic Potential of Somatostatin and Its Analogues in Alzheimer's Disease: From Molecular Mechanisms to Preclinical Studies.​

This review discusses the therapeutic potential of somatostatin and its analogues in Alzheimer's disease, highlighting their multitarget effects. The findings suggest that somatostatin could modulate key pathological processes in AD. This research underscores the need for novel therapeutic approaches in neurodegenerative diseases.

Liu K, Zhang XY, Wang YT et al. · Molecular neurobiology · (2026) · View on PubMed ↗

Machine Learning-Based Sleep Electroencephalographic Brain Age Index and Dementia Risk: An Individual Participant Data Meta-Analysis.​

This meta-analysis examined the association between sleep electroencephalographic brain age index and dementia risk, revealing significant correlations. The findings suggest that sleep EEG patterns could serve as biomarkers for dementia risk assessment. This research highlights the potential for sleep studies in cognitive health monitoring.

Sun H, Milton S, Fang Y et al. · JAMA network open · (2026) · View on PubMed ↗

Transcriptomic Insights Into Alzheimer's Disease: Differentially Expressed Genes and Cholesterol Metabolism.​

This study explored the differential expression of genes related to cholesterol metabolism in Alzheimer's disease, highlighting potential biomarkers for early detection. The findings suggest that targeting cholesterol metabolism could be a therapeutic strategy for AD. This research contributes to understanding the metabolic aspects of neurodegeneration.

Sun R, Wang X, Wang Z et al. · CNS neuroscience & therapeutics · (2026) · View on PubMed ↗

Phospholipid Glutathione Peroxidase Overexpression Mitigates Cancer Cachexia by Protecting Muscle Mass and Lowering Inflammation.​

This study found that early-life melatonin supplementation reduces behavioral and molecular alterations in a rat model of autism spectrum disorder. The findings suggest that melatonin may have protective effects on neurodevelopment. This research highlights the potential for melatonin as a therapeutic option in ASD.

Duggan E, Fuqua JD, Hagy B et al. · Journal of cachexia, sarcopenia and muscle · (2026) · View on PubMed ↗

Endocrinology​

Glucagon-like peptide-1 receptor agonists for major cardiovascular and kidney outcomes in type 1 diabetes.​

This study assessed the long-term cardiovascular and kidney outcomes of glucagon-like peptide-1 receptor agonists in patients with type 1 diabetes using national health records. The findings indicated that GLP-1RA initiation was associated with lower risks of major adverse cardiovascular events and end-stage kidney disease. This suggests that GLP-1RAs could be beneficial in managing cardiovascular and renal complications in type 1 diabetes.

Xu Y, Malek ND, Chang AR et al. · Nature medicine · (2026) · View on PubMed ↗

Proteomic analyses of human islets reveal potential markers of β-cell dysfunction during prediabetes.​

This study utilized proteomic analyses to identify markers of β-cell dysfunction during prediabetes. The findings suggest that specific protein changes could predict diabetes onset. This research could inform early intervention strategies for preventing type 2 diabetes.

Cefalo CMA, Mezza T, Quero G et al. · JCI insight · (2026) · View on PubMed ↗

Infectious Disease​

LRP8 is a functional receptor for yellow fever virus.​

This research identified LRP8 as a functional receptor for yellow fever virus, enhancing our understanding of viral entry mechanisms. The study demonstrated that LRP8 promotes infection by facilitating viral entry in cell lines. This knowledge could inform vaccine development and therapeutic strategies against yellow fever virus.

Mei M, Yang Y, Zhang Z et al. · Nature microbiology · (2026) · View on PubMed ↗

ALG6 orchestrates coronavirus replication via the endoplasmic reticulum stress-autophagy axis.​

This study identified ALG6 as a host factor essential for coronavirus replication via the endoplasmic reticulum stress-autophagy axis. The findings suggest that targeting ALG6 could inhibit viral replication. This research provides insights into potential therapeutic strategies against coronaviruses.

Fu Y, Gao M, Fu Z et al. · Cell reports · (2026) · View on PubMed ↗

Association between COVID-19 vaccination and sudden death in apparently healthy younger individuals: A population-based case-control study.​

The study examined the association between COVID-19 vaccination and sudden death in younger individuals, finding no significant link. This research addresses public concerns regarding vaccine safety in healthy populations. The findings contribute to the ongoing evaluation of vaccine safety profiles.

Abdel-Qadir H, Bhatt HA, Swayze S et al. · PLoS medicine · (2026) · View on PubMed ↗

Gastroenterology​

CD177⁺ neutrophil-platelet aggregates contribute to thromboinflammation via NETs in necrotizing enterocolitis.​

This study identified CD177⁺ neutrophil-platelet aggregates as contributors to thromboinflammation in necrotizing enterocolitis (NEC). The findings highlight the role of immunothrombosis in NEC pathogenesis, suggesting potential therapeutic targets. This research could lead to improved management strategies for NEC in premature infants.

Lan C, Tian B, Shi Y et al. · Nature communications · (2026) · View on PubMed ↗

Host-derived nitrate fuels indole production by Escherichia coli to drive chronic kidney disease progression.​

The study investigated how host-derived nitrate fuels indole production by E. coli, contributing to chronic kidney disease progression. The findings suggest that microbial metabolism plays a role in CKD, highlighting the gut-kidney axis. This could inform therapeutic strategies targeting microbiota in CKD management.

Lee JY, Mahan SP, Parente de Carvalho T et al. · Science (New York, N.Y.) · (2026) · View on PubMed ↗

ECM1 produced by hepatic stellate cells serves as gate keeper of liver homeostasis in hepatic fibrosis.​

This study examined the role of ECM1 produced by hepatic stellate cells in liver homeostasis and fibrosis. The findings suggest that ECM1 is crucial for maintaining liver health and could be a therapeutic target in liver diseases. This research underscores the importance of understanding cellular interactions in liver pathology.

Yang A, Yan X, Wang Y et al. · Hepatology (Baltimore, Md.) · (2026) · View on PubMed ↗

Respiratory Medicine​

Clinical practice guideline for long COVID prevention and treatment.​

This clinical practice guideline addresses long COVID prevention and treatment, providing evidence-based recommendations for healthcare providers. The guideline emphasizes the importance of a multidisciplinary approach in managing long COVID symptoms. This resource aims to enhance care for patients suffering from long COVID.

Cao B, Soriano JB, Wang Q et al. · The European respiratory journal · (2026) · View on PubMed ↗

Epidemiology, ventilation, and outcomes of acute respiratory failure in immunocompromised patients from 103 intensive care units in 26 countries: a retrospective observational study.​

This retrospective observational study examined acute respiratory failure in immunocompromised patients across 103 ICUs in 26 countries. The study identified predictors of mortality and intubation, providing valuable insights into managing ARF in this vulnerable population. These findings could inform clinical practices and improve patient outcomes.

Azoulay E, McEvoy C, Castro P et al. · The Lancet. Respiratory medicine · (2026) · View on PubMed ↗

Psychiatry​

The efficacy and safety of cannabinoids for the treatment of mental disorders and substance use disorders: a systematic review and meta-analysis.​

This systematic review and meta-analysis evaluated the efficacy and safety of cannabinoids for treating mental disorders and substance use disorders. The findings indicate mixed results regarding their effectiveness, underscoring the need for further research. This highlights the complexity of using cannabinoids in psychiatric treatment.

Wilson J, Dobson O, Langcake A et al. · The lancet. Psychiatry · (2026) · View on PubMed ↗

Orthopedics​

FGF21-Mediated Upregulation of SIRT1 Delays Intervertebral Disc Degeneration by Promoting PINK1/Parkin Dependent Mitophagy Through Deacetylation of FOXO3.​

The study explored the role of FGF21 in delaying intervertebral disc degeneration (IDD) by promoting mitophagy through SIRT1 upregulation. FGF21 was found to be downregulated in degenerated discs, correlating with senescence markers and clinical features. This suggests that FGF21 could be a potential therapeutic target for preventing IDD and associated back pain.

Wu ZL, Ran R, Xie QQ et al. · Aging cell · (2026) · View on PubMed ↗

Apoptotic extracellular vesicles derived from MSCs exposed to hypoxic and inflammatory environments slow intervertebral disc degeneration by enhancing cell activity and regulating immunity microenvironment.​

The study demonstrated that apoptotic extracellular vesicles from mesenchymal stem cells exposed to hypoxic and inflammatory environments can slow intervertebral disc degeneration by enhancing cell activity and modulating the immune microenvironment. This suggests a potential therapeutic application of stem cell-derived vesicles in treating degenerative disc diseases. The findings could lead to innovative strategies for managing intervertebral disc degeneration.

Zhang W, Ma X, Yin H et al. · Materials today. Bio · (2026) · View on PubMed ↗

Disruption of iron homeostasis by HERC2-FTL axis leads to chondrocyte loss and exacerbates osteoarthritis.​

This study investigated the role of iron homeostasis disruption in osteoarthritis progression, identifying the HERC2-FTL axis as a key regulator. The findings suggest that targeting this axis could mitigate cartilage loss and inflammation. This research highlights potential therapeutic strategies for osteoarthritis management.

Zhong Y, Duan J, Chen Z et al. · Apoptosis : an international journal on programmed cell death · (2026) · View on PubMed ↗

Dermatology​

Psoriasis modulates inflammatory bowel disease risk and intestinal epithelium lipid metabolism via IL-1β-producing macrophages.​

The study investigated the relationship between psoriasis and inflammatory bowel disease risk, revealing that psoriasis severity correlates with impaired intestinal lipid metabolism. This suggests that psoriasis may influence gut health and increase the risk of developing inflammatory bowel disease. Understanding this link could inform management strategies for patients with psoriasis.

Wu J, Liu S, Dan W et al. · Cell metabolism · (2026) · View on PubMed ↗

A neuroimmune circuit links stress to skin inflammation.​

This study identified a neuroimmune circuit linking stress to skin inflammation, specifically in atopic dermatitis. The findings suggest that sympathetic neurons activate eosinophils during stress, exacerbating inflammation. This could inform new therapeutic approaches for managing stress-related skin conditions.

Gaudenzio N, Basso L · Science (New York, N.Y.) · (2026) · View on PubMed ↗

A sympathetic-eosinophil axis orchestrates psychological stress to exacerbate skin inflammation.​

The study identified a sympathetic-eosinophil axis that exacerbates skin inflammation during psychological stress. The findings suggest that targeting this axis could mitigate stress-induced dermatitis. This research provides insights into the neuroimmune interactions affecting skin health.

Tian J, Cao Y, Li Y et al. · Science (New York, N.Y.) · (2026) · View on PubMed ↗

Ritlecitinib for Severe Alopecia Areata: A 24-Week, Multicentre, Real-World Study.​

This study evaluated the effectiveness of ritlecitinib for treating severe alopecia areata in a real-world setting. The findings indicate that ritlecitinib is effective and well-tolerated in clinical practice. This adds to the evidence supporting the use of targeted therapies in alopecia areata.

Starace M, Rapparini L, Pampaloni F et al. · American journal of clinical dermatology · (2026) · View on PubMed ↗

International Dermoscopy Society consensus recommendations for the management of lentigo maligna.​

This review discusses the management of lentigo maligna, providing consensus recommendations for clinicians. The findings emphasize the need for evidence-based strategies in diagnosing and treating this challenging condition. This research aims to improve care for patients with lentigo maligna.

Forsea AM, Pampena R, Akay BN et al. · Journal of the European Academy of Dermatology and Venereology : JEADV · (2026) · View on PubMed ↗

Biotechnology​

Effectiveness of Al-Assisted Patient Health Education Using Voice Cloning and ChatGPT: Prospective Randomized Controlled Trial.​

This study evaluated the effectiveness of AI-assisted patient education using voice cloning and ChatGPT in improving patient knowledge and treatment adherence. The results indicated that AI-driven education significantly enhanced patient engagement compared to traditional methods. This highlights the potential of AI technologies in personalized healthcare education.

Sun Y, Xu S, Jin H et al. · Journal of medical Internet research · (2026) · View on PubMed ↗

Commensal-driven serotonin production modulates in vivo delivery of synthetic and viral vectors.​

The research identified that gut microbiota influence the delivery efficiency of synthetic and viral vectors in vivo through serotonin production. Disrupting commensal-host interactions improved drug delivery outcomes. This suggests that microbiome modulation could enhance the effectiveness of therapeutic delivery systems.

Wang Q, Chen Z, Zhang G et al. · Science (New York, N.Y.) · (2026) · View on PubMed ↗

Resetting of a tandem microRNA156 enables vegetative perennial growth in rice.​

This study explored the genetic mechanisms underlying perennial growth in rice, identifying the EBT1 locus responsible for this trait. The findings suggest that manipulating this locus could enhance rice cultivation practices. This research has implications for agricultural biotechnology and crop improvement.

Dai B, Lv D, Chen E et al. · Science (New York, N.Y.) · (2026) · View on PubMed ↗

Phase separation of Rht8-derived RNHL1 integrates ethylene and gibberellin signaling to regulate wheat internode elongation.​

This study examined the roles of Rht8-derived RNHL1 in regulating wheat internode elongation through phase separation mechanisms. The findings suggest that RNHL1 interacts with ethylene signaling to control plant growth. This research has implications for agricultural biotechnology and crop improvement.

Dong C, Cheng X, Yuan M et al. · The Plant cell · (2026) · View on PubMed ↗

Other​

Efficacy and Safety of Remimazolam Tosylate versus Propofol for Sedation of Postoperative Mechanically Ventilated Patients in Intensive Care Units: a Multicenter, Randomized, Single-blind, Non-inferiority, Phase 3 trial.​

This phase 3 trial compared remimazolam tosylate to propofol for sedation in mechanically ventilated patients in ICUs. The findings demonstrated that remimazolam was non-inferior in safety and effectiveness, suggesting it as a viable alternative for sedation. This could improve sedation practices in critical care settings.

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Meat Consumption and Cognitive Health by APOE Genotype.​

This study examined the relationship between meat consumption and cognitive health by APOE genotype, finding that higher meat intake may benefit cognitive health in certain genotypes. The findings suggest that dietary recommendations could be tailored based on genetic risk factors for Alzheimer's disease. This research underscores the importance of personalized nutrition in cognitive health.

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Identification and Validation of miR-206-3p Targeting WT-1 Promotes Membranous Nephropathy Through a Comprehensive Bioinformatics and Machine Learning Algorithm.​

This study identified and validated miR-206-3p as a promoter of membranous nephropathy through bioinformatics and machine learning approaches. The findings suggest that targeting this microRNA could offer new therapeutic avenues for treating membranous nephropathy. This research highlights the potential of precision medicine in kidney disease management.

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The relationship between dietary patterns and neuroinflammation.​

This review discusses the relationship between dietary patterns and neuroinflammation, emphasizing the role of nutrition in CNS health. The findings suggest that specific dietary choices could modulate neuroinflammatory responses. This research highlights the potential for dietary interventions in preventing neurodegenerative diseases.

View on PubMed ↗

Generated automatically on March 21, 2026 from PubMed's trending articles. Summaries are AI-generated; always consult the original publication for clinical or research decisions.