PubMed Trending Research Digest — March 21, 2026
Automated digest · 99 articles · 15 research areas · March 21, 2026
Overview
This week's trending research highlights significant advancements across various biomedical fields, particularly in oncology, neurology, and metabolic disease. Notable studies include the development of targeted therapies for cancer, such as the ERAD-engaging chimeras for degrading PD-L1 and the bispecific nanobody-drug conjugate for pancreatic cancer, which could enhance treatment efficacy. Additionally, research into the role of gut microbiota in neuropsychiatric disorders and the implications of dietary patterns on neuroinflammation underscores the growing recognition of the microbiome's impact on health. Overall, these findings reflect the dynamic nature of current biomedical research, emphasizing the integration of novel technologies and interdisciplinary approaches to address complex health challenges.
Neurology
Effect of a clinical decision support system on stroke care quality and outcomes in patients with acute ischaemic stroke (GOLDEN BRIDGE II): cluster randomised clinical trial.
This study evaluated the efficacy of a clinical decision support system (CDSS) on stroke care quality and outcomes among 21,603 patients with acute ischaemic stroke across 77 hospitals in China. The implementation of CDSS significantly improved stroke care quality and clinical outcomes compared to standard care. This finding suggests that integrating AI-assisted tools in clinical settings could enhance patient management and outcomes in acute stroke care.
Zhang X, Ding L, Jing J et al. · BMJ (Clinical research ed.) · (2026) · View on PubMed ↗
Tavapadon as Adjunctive Treatment for Parkinson Disease: The TEMPO-3 Randomized Clinical Trial.
The TEMPO-3 trial evaluated the efficacy and safety of tavapadon, a selective D1/D5 agonist, as adjunctive treatment for Parkinson's disease patients experiencing motor fluctuations. Tavapadon significantly improved motor control while minimizing adverse events compared to traditional D2/D3 agonists. This highlights the potential for D1/D5 agonists to offer safer therapeutic options for managing Parkinson's disease.
Fernandez HH, Isaacson SH, Hauser RA et al. · JAMA neurology · (2026) · View on PubMed ↗
Mitoxyperilysis: fasting-induced cell death in immunometabolism and disease.
This study developed a predictive atlas using retinal fundus photographs to assess disease onset risk across various conditions. The findings indicate that retinal imaging could serve as a non-invasive tool for early disease detection. This approach may enhance preventive healthcare strategies by identifying at-risk individuals.
Al-Zidan R, Gautam M, Man SM · Trends in biochemical sciences · (2026) · View on PubMed ↗
Transplantation of encapsulated mitochondria alleviates dysfunction in mitochondrial and Parkinson's disease models.
This research evaluated the transplantation of encapsulated mitochondria in models of mitochondrial dysfunction and Parkinson's disease. The findings indicated that this approach effectively alleviated dysfunction and restored bioenergetic properties. This could represent a novel therapeutic strategy for mitochondrial diseases.
Du S, Long Q, Zhou Y et al. · Cell · (2026) · View on PubMed ↗
International Expert Opinion on Optimal Switching to Cladribine Tablets from Other High-Efficacy Disease-Modifying Therapies for Relapsing-Remitting Multiple Sclerosis: Opportunities and Challenges.
This expert opinion discusses optimal switching strategies to cladribine tablets for multiple sclerosis patients previously treated with high-efficacy therapies. The recommendations aim to improve treatment outcomes and patient management. This highlights the need for evidence-based guidelines in multiple sclerosis care.
Chan A, Alroughani R, Calabrese M et al. · Neurology and therapy · (2026) · View on PubMed ↗
Transradial vs Transfemoral Access for Cerebral Angiography: A Randomized Noninferiority Clinical Trial.
This randomized trial compared transradial access to transfemoral access for cerebral angiography, finding that transradial access is a safe and effective alternative. The results suggest that TRA could enhance patient comfort and reduce complications. This research could influence procedural practices in neurointerventional radiology.
Ni W, Yang H, Su J et al. · JAMA network open · (2026) · View on PubMed ↗
Women with epilepsy: Evidence-based counseling across the lifespan.
This review discusses the unique challenges faced by women with epilepsy across their lifespan, emphasizing the need for tailored clinical management. The findings highlight gaps in care and the importance of integrating sex-specific considerations into epilepsy treatment. This research aims to enhance the quality of care for women with epilepsy.
Tettenborn B, Ramantani G, Flügel D et al. · Epilepsia · (2026) · View on PubMed ↗
Onasemnogene Abeparvovec in Type I Spinal Muscular Atrophy: 24-Month Follow-Up From the Italian Registry.
This study evaluated the long-term outcomes of onasemnogene abeparvovec in type I spinal muscular atrophy, providing valuable real-world data. The findings indicate that this gene therapy is effective in improving patient outcomes over 24 months. This research contributes to the understanding of gene therapy in neuromuscular disorders.
Pane M, Coratti G, Cutrì C et al. · Annals of clinical and translational neurology · (2026) · View on PubMed ↗
Oncology
Hijacking ERAD for targeted degradation of transmembrane proteins.
The researchers developed a targeted protein degradation technology called ERAD-engaging chimeras (ERADECs) to efficiently degrade transmembrane proteins, specifically targeting programmed death-ligand 1 (PD-L1). They demonstrated that this approach could effectively reduce PD-L1 levels, which is significant for cancer immunotherapy. This technology could pave the way for novel therapeutic strategies in targeting difficult-to-degrade proteins in various diseases.
Song H, Wang W, Mei T et al. · Cell · (2026) · View on PubMed ↗
Lactylation Converts ABHD6 into a Mitochondrial Regulator that Drives Lenvatinib Resistance in Hepatocellular Carcinoma.
The study identified that lactylation converts ABHD6 into a mitochondrial regulator that drives resistance to lenvatinib in hepatocellular carcinoma (HCC). The research found that ABHD6's non-canonical scaffolding function, rather than its enzymatic activity, contributed to this resistance. This insight into the metabolic adaptations in HCC could inform new therapeutic strategies to overcome drug resistance.
Sun Y, Luo C, Yang H et al. · Cancer research · (2026) · View on PubMed ↗
Trends in 5-year net survival for women diagnosed with breast, cervical or ovarian cancer in Japan, 2000-14 (CONCORD-3).
The study analyzed long-term survival trends for women diagnosed with breast, cervical, or ovarian cancer in Japan from 2000 to 2014 using data from the CONCORD-3 project. The findings indicated improvements in five-year net survival rates for these cancers over the study period. This highlights progress in cancer treatment and early detection efforts in Japan.
Watanabe K, Di Carlo V, Sugiyama H et al. · Japanese journal of clinical oncology · (2026) · View on PubMed ↗
Targeting tumor-associated macrophages-induced IGF1/PI3K/Zic1 axis triggers SHH medulloblastoma regression and chemosensitization.
The study investigated the role of tumor-associated macrophages in medulloblastoma progression and chemoresistance by targeting the IGF1/PI3K/Zic1 axis. The findings suggest that inhibiting this axis can trigger tumor regression and enhance chemotherapy sensitivity. This approach could lead to improved treatment strategies for medulloblastoma.
Pang YC, Wang C, Qiu JF et al. · Neuro-oncology · (2026) · View on PubMed ↗
Liquid biopsy for the diagnosis of EBV-positive Burkitt's lymphoma in endemic areas.
The study evaluated the diagnostic accuracy of liquid biopsies for EBV-positive Burkitt's lymphoma in endemic areas, demonstrating their potential for rapid diagnosis. The use of circulating tumor DNA markers improved diagnostic turnaround time compared to traditional methods. This approach could enhance early detection and treatment of Burkitt's lymphoma in resource-limited settings.
Chamba C, Christopher H, Josephat E et al. · Nature medicine · (2026) · View on PubMed ↗
Extrachromosomal DNA in urothelial carcinoma: mechanisms and clinical applications.
The review discusses the mechanisms and clinical applications of extrachromosomal DNA (ecDNA) in urothelial carcinoma, highlighting its role in genomic instability and tumor evolution. The detection of ecDNA through non-invasive liquid biopsies offers potential for early diagnosis and monitoring. Understanding ecDNA biology could lead to novel therapeutic strategies for urothelial carcinoma.
Li C, Hu Z, Zhang W et al. · Nature reviews. Urology · (2026) · View on PubMed ↗
Targeting WIP1 reprograms immunosuppressive tumor microenvironment to potentiate immunotherapy response in colorectal cancer.
This study identified WIP1 as a critical immunosuppressive driver in colorectal cancer, with its inhibition enhancing anti-tumor immune responses. The research demonstrated that targeting WIP1 remodels the tumor immune microenvironment, increasing macrophage and T cell infiltration. This suggests that WIP1 inhibition could improve the efficacy of immunotherapy in colorectal cancer.
Chen L, Chen M, Yuan S et al. · Cell death and differentiation · (2026) · View on PubMed ↗
SHR-A1811, a novel HER2-targeting antibody-drug conjugate, in advanced solid tumors (HORIZON-X): a global phase 1 trial.
The HORIZON-X trial evaluated SHR-A1811, a novel HER2-targeting antibody-drug conjugate, in patients with advanced solid tumors. The results showed substantial antitumor activity, indicating its potential as a treatment option for HER2-expressing tumors. This study highlights the promise of targeted therapies in oncology.
Yao H, Yan M, Tong Z et al. · Signal transduction and targeted therapy · (2026) · View on PubMed ↗
A predictive atlas of disease onset from retinal fundus photographs: a modelling study using data from population-based cohorts.
This systematic review and meta-analysis evaluated the prognostic significance of microsatellite instability (MSI), PD-L1 expression, and Epstein-Barr virus (EBV) positivity in gastric cancer. The findings suggest that these biomarkers are important for treatment selection and prognosis in gastric cancer patients. This underscores the need for personalized approaches in gastric cancer management.
Buergel T, Loock L, Steinfeldt J et al. · The Lancet. Digital health · (2026) · View on PubMed ↗
Risk Assessment in Large B-Cell Lymphoma Using Metabolic Tumor Volume: Real-World Data from a Multicenter Cohort of Patients Undergoing CAR T-Cell Therapy.
This study assessed the use of metabolic tumor volume (MTV) as a risk assessment tool in large B-cell lymphoma patients undergoing CAR T-cell therapy. The findings suggest that MTV may provide better prognostic information than traditional methods. This could improve patient stratification and treatment outcomes in lymphoma therapy.
Voltin CA, Flossdorf S, Kurch L et al. · Journal of nuclear medicine : official publication, Society of Nuclear Medicine · (2026) · View on PubMed ↗
Hypoxia-related and immune phenotype-related fusion model for non-invasive prognostication of hepatocellular carcinoma treated by TACE: a multicentre study.
The study developed a hypoxia-related and immune phenotype-related fusion model for prognostication in hepatocellular carcinoma treated with transarterial chemoembolization (TACE). The model demonstrated improved predictive accuracy for patient survival outcomes. This could enhance clinical decision-making in HCC management.
Guo Y, Zhang G, Fu X et al. · Gut · (2026) · View on PubMed ↗
CAV1-DOT1L axis in TAM-derived EVs orchestrates VM and sensitises PDAC to combined VM and VEGF targeting.
This research explored the role of the CAV1-DOT1L axis in tumor-associated macrophages and its impact on vasculogenic mimicry in pancreatic ductal adenocarcinoma (PDAC). The findings suggest that targeting this axis could sensitize PDAC to combined therapies. This highlights potential therapeutic strategies for overcoming resistance in pancreatic cancer.
Liu Z, Zhang Y, Wu H et al. · Gut · (2026) · View on PubMed ↗
A bispecific nanobody-drug conjugate targeting TROP2 and c-Met for low-concentration, single-dose treatment of pancreatic cancer.
This study introduced a bispecific nanobody-drug conjugate targeting TROP2 and c-Met for treating pancreatic cancer. Preclinical results demonstrated potent cytotoxicity and superior tumor inhibition compared to existing therapies. This suggests a promising new direction for targeted cancer treatments.
Ning W, Liu H, Zeng H et al. · Cell reports. Medicine · (2026) · View on PubMed ↗
Preferences in Cyclin-Dependent Kinase 4/6 Inhibitors for Advanced Breast Cancer Among Medical Oncologists in Latin America.
This cross-sectional survey examined preferences for cyclin-dependent kinase 4/6 inhibitors among medical oncologists in Latin America treating advanced breast cancer. The results showed a preference for ribociclib, influenced by availability and clinical scenarios. This highlights the need for better access to effective therapies in the region.
Villarreal-Garza C, Meraz-Brenez A, Reyes Morales A et al. · JCO global oncology · (2026) · View on PubMed ↗
Overcoming T cell tolerance to tumor self-antigens through catch-bond engineering.
The study developed a method to engineer T cells to overcome tolerance to tumor self-antigens, enhancing their anti-tumor activity. The findings indicate that catch-bond engineering can improve T cell responses against tumors. This approach could lead to more effective immunotherapies for cancer.
Chen X, Mao Z, Kolawole EM et al. · Science (New York, N.Y.) · (2026) · View on PubMed ↗
A CHKA-PML autophagy checkpoint enables tumors to evade glutamine starvation.
The study identified a CHKA-PML autophagy checkpoint that enables tumors to evade glutamine starvation. The findings suggest that targeting this checkpoint could enhance the efficacy of cancer therapies. This research highlights the adaptive mechanisms tumors use to survive metabolic stress.
Wang R, Cao L, He X et al. · Proceedings of the National Academy of Sciences of the United States of America · (2026) · View on PubMed ↗
Post hoc estimation of a quantitative restriction spectrum imaging biomarker for prostate cancer detection using conventional MRI.
This study evaluated the diagnostic performance of restriction spectrum imaging for prostate cancer detection using conventional MRI. The findings suggest that this technique improves detection accuracy for clinically significant prostate cancer. This could enhance diagnostic capabilities in prostate cancer management.
Do DD, Conlin CC, Bagrodia A et al. · Journal of applied clinical medical physics · (2026) · View on PubMed ↗
Unveiling the multifaceted roles of BCL3: biological functions and disease implications.
This review outlines the multifaceted roles of BCL3 in cancer biology, including its regulatory functions in the NF-κB signaling pathway. The findings suggest that BCL3 may serve as a potential therapeutic target in various malignancies. This research contributes to the understanding of oncogenic mechanisms.
Guo X, Guo R, Wang W et al. · Apoptosis : an international journal on programmed cell death · (2026) · View on PubMed ↗
Long-term outcomes of eribulin‑based neoadjuvant chemotherapy for triple‑negative breast cancer patients stratified by homologous recombination deficiency status: results of the randomized JBCRG-22 study.
This study evaluated long-term outcomes of eribulin-based neoadjuvant chemotherapy in triple-negative breast cancer patients based on homologous recombination deficiency status. The findings suggest that HRD status may influence treatment efficacy and patient outcomes. This research could inform personalized treatment strategies in breast cancer.
Masuda N, Yasojima H, Bando H et al. · Breast cancer research and treatment · (2026) · View on PubMed ↗
The therapeutic potential of Piezo1 channel-mediated ferroptosis and its inhibitor.
This study explored the therapeutic potential of Piezo1 channel-mediated ferroptosis in cancer treatment. The findings suggest that targeting Piezo1 could enhance ferroptosis and improve cancer therapy outcomes. This research highlights the importance of understanding cell death mechanisms in cancer treatment.
Nan K, Zhang L, Zhao Y et al. · Apoptosis : an international journal on programmed cell death · (2026) · View on PubMed ↗
Gsα deficiency in macrophages promotes tumor progression via the MAPK signaling pathway.
This study examined the role of Gsα deficiency in macrophages and its impact on tumor progression via the MAPK signaling pathway. The findings indicate that Gsα deficiency accelerates tumor growth and metastasis. This research suggests that targeting Gsα could be a potential strategy for cancer immunotherapy.
Yan W, Yang J, Tan S et al. · Journal of molecular medicine (Berlin, Germany) · (2026) · View on PubMed ↗
Bireociclib Plus Fulvestrant in Advanced Breast Cancer After Endocrine Progression: The BRIGHT-2 Phase 3 Randomized Clinical Trial.
This phase 3 trial evaluated the efficacy of bireociclib plus fulvestrant in advanced breast cancer after endocrine therapy progression. The findings demonstrated significant improvements in treatment outcomes, suggesting this combination could be a viable option for patients. This research contributes to the evolving landscape of breast cancer therapy.
Wang J, Zhang Q, Li H et al. · JAMA oncology · (2026) · View on PubMed ↗
Diagnostic Performance of Anti-Epstein-Barr Virus BNLF2b in Suspected Nasopharyngeal Carcinoma.
This study assessed the diagnostic performance of anti-EBV BNLF2b in suspected nasopharyngeal carcinoma, finding it to be a reliable biomarker. The results suggest that this assay could improve early detection and reduce misdiagnosis rates. This research highlights the importance of accurate biomarkers in cancer diagnostics.
Li SC, Li FG, Wu SJ et al. · JAMA oncology · (2026) · View on PubMed ↗
HTRA1+ macrophages induce T cells egress through CRIP1/NF-κB/CXCL12 to limit the effects of immunotherapy in triple-negative breast cancer.
The study examined the role of HTRA1+ macrophages in triple-negative breast cancer, revealing their involvement in T cell egress and immunotherapy response. The findings suggest that targeting these macrophages could enhance immunotherapy efficacy. This research underscores the importance of understanding tumor-immune interactions in cancer treatment.
Weng J, Xu W, Wang F et al. · Cancer immunology research · (2026) · View on PubMed ↗
Stage-specific transcriptomics of a leader cell reveals cell machineries driving collective invasion.
This study investigated the stage-specific transcriptomics of leader cells in collective invasion, providing insights into the molecular mechanisms driving this process. The findings suggest that specific gene expression profiles are crucial for leader cell functions during invasion. This research could inform strategies to target cancer metastasis.
Agarwal P, Maimon Zielonka I, Gingold H et al. · The Journal of cell biology · (2026) · View on PubMed ↗
Use of ctDNA in Older Women with ER+ Breast Cancer to Facilitate Surgical De-escalation: A Prospective, Hybrid-Decentralized Trial with Correlative Studies.
This prospective trial evaluated the use of circulating tumor DNA in older women with ER+ breast cancer to facilitate surgical de-escalation. The findings suggest that ctDNA levels could guide treatment decisions and improve patient outcomes. This research highlights the potential for personalized approaches in breast cancer management.
Carleton N, Chang AC, Chen F et al. · Clinical cancer research : an official journal of the American Association for Cancer Research · (2026) · View on PubMed ↗
Albumin-Bound STING Agonist Reprograms HSPCs to Antitumor Neutrophils Enhancing CD8+ T Cell Immunity.
This study investigated the effects of an albumin-bound STING agonist on reprogramming hematopoietic stem and progenitor cells to enhance antitumor immunity. The findings suggest that this approach could improve responses to immunotherapy. This research highlights the potential for innovative strategies in cancer treatment.
Tao J, Zhao HY, Li C et al. · Advanced science (Weinheim, Baden-Wurttemberg, Germany) · (2026) · View on PubMed ↗
PMID 41854222
This study explored the role of phospholipid glutathione peroxidase in mitigating cancer cachexia by protecting muscle mass and reducing inflammation. The findings suggest that targeting oxidative stress could be a therapeutic strategy for cancer cachexia. This research underscores the importance of addressing muscle health in cancer patients.
Regulation of YAP activity by nuclear G-actin binding.
This study investigated the regulation of YAP activity by nuclear G-actin binding, revealing its role in cellular processes. The findings suggest that G-actin binding modulates YAP's transcriptional activity. This research contributes to understanding the mechanistic pathways involved in cell growth and cancer.
Wang H, Jayawardana IM, Fleisch JM et al. · Nucleic acids research · (2026) · View on PubMed ↗
Cardiovascular Medicine
USP25 regulates atherosclerosis by restricting RIPK1-mediated inflammatory responses.
This study investigated the role of the deubiquitinating enzyme USP25 in atherosclerosis using mouse models and human atherosclerotic lesions. The findings revealed that USP25 is downregulated in atherosclerotic lesions and its expression is crucial for regulating inflammatory responses mediated by RIPK1. This suggests that targeting USP25 could be a potential therapeutic strategy for managing atherosclerosis and its associated inflammatory processes.
Su X, Zhou B, Xu Y et al. · EBioMedicine · (2026) · View on PubMed ↗
Prognostic Impact of Elevated Pulmonary Vascular Resistance in Group 2 Pulmonary Hypertension: Insights From a Japanese Multicenter Registry.
This study assessed the prognostic impact of elevated pulmonary vascular resistance in patients with Group 2 pulmonary hypertension using data from two Japanese multicenter registries. The analysis revealed that higher pulmonary vascular resistance was associated with worse outcomes, including increased hospitalization and mortality. These findings underscore the importance of monitoring pulmonary vascular resistance in managing patients with pulmonary hypertension.
Satoh T, Sugimura K, Fukumoto Y et al. · Journal of the American Heart Association · (2026) · View on PubMed ↗
Stroke Risk After Bioprosthetic Aortic Valve Replacement in Aortic Stenosis: Systematic Review and Meta-Analysis.
This systematic review and meta-analysis examined the incidence of stroke following bioprosthetic aortic valve replacement in patients with aortic stenosis. The study found a significant proportion of patients experienced ischemic stroke within the periprocedural period. These insights are crucial for improving patient management and risk stratification in cardiac surgery.
Bou Dargham T, Hassani S, Mac Grory BC et al. · Stroke · (2026) · View on PubMed ↗
Inhibiting RhoA Activation Via GDP-State Stabilization to Relieve Heart Failure.
The study investigated the inhibition of RhoA activation as a potential therapeutic strategy for heart failure by stabilizing its GDP-bound state. The findings suggest that targeting RhoA could mitigate pathological myocardial remodeling and improve heart function. This approach may represent a novel avenue for heart failure treatment.
Xue M, Liang Y, Yuan Z et al. · Circulation research · (2026) · View on PubMed ↗
Fibrinogen-Bmal1 signaling as a therapeutic target to limit aortic dissection by preserving VSMC contractility.
The study explored fibrinogen-Bmal1 signaling as a therapeutic target to limit aortic dissection by preserving vascular smooth muscle cell contractility. The findings suggest that higher plasma fibrinogen levels are associated with better clinical outcomes in aortic dissection patients. This could inform new treatment strategies for managing aortic dissection.
Zhong X, Li D, Zhao Y et al. · Signal transduction and targeted therapy · (2026) · View on PubMed ↗
Integration of Epidemiology and Network Toxicology Revealed the Arrhythmogenic Potential of Neonicotinoid Insecticides.
The study assessed the arrhythmogenic potential of neonicotinoid insecticides using epidemiological and network toxicology approaches. Findings indicated that exposure to neonicotinoids was associated with increased arrhythmia risk in patients. This raises concerns about the safety of these widely used insecticides and their potential health impacts.
Ge Y, Xiao Q, Fu B et al. · Environmental science & technology · (2026) · View on PubMed ↗
Immunology
Postural Orthostatic Tachycardia Syndrome, Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Long COVID as Neuroimmune Disorders.
This article explores the neuroimmune mechanisms underlying Postural Orthostatic Tachycardia Syndrome (POTS), myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), and Long COVID. The study identifies common pathophysiological factors such as autonomic dysfunction and immune dysregulation. Understanding these connections may inform treatment approaches for these overlapping disorders.
Blitshteyn S, Doherty TA, Steinman L · ImmunoTargets and therapy · (2026) · View on PubMed ↗
PMID 41856896
The review discusses mitoxyperilysis, a novel cell death mechanism linked to immunometabolism and disease, particularly in sepsis and cancer. This unique form of cell death is triggered by immune agonists combined with fasting, suggesting potential therapeutic implications. Understanding this process could lead to innovative treatment strategies in critical care.
Anifrolumab in systemic lupus erythematosus: real-world evidence from a Spanish multicentre cohort of 206 patients and literature review.
This study evaluated the real-world effectiveness of anifrolumab in patients with systemic lupus erythematosus (SLE) across multiple centers in Spain. The findings indicate that anifrolumab is effective and well-tolerated in clinical practice. This adds to the growing body of evidence supporting the use of anifrolumab in SLE management.
Calvo-Río V, Secada-Gómez C, Martín Gutiérrez A et al. · RMD open · (2026) · View on PubMed ↗
Quantifying immune dysregulation in pneumonia and sepsis with a parsimonious machine-learning model: a multicohort analysis across care settings and reanalysis of a hydrocortisone randomised controlled trial.
The study developed a machine-learning model to quantify immune dysregulation in pneumonia and sepsis, aiming to improve prognostication and treatment responses. The model showed promise in identifying patients who may benefit from immunomodulation therapies. This approach could enhance personalized medicine strategies in critical care.
Michels EHA, Dequin PF, Butler JM et al. · The Lancet. Respiratory medicine · (2026) · View on PubMed ↗
A Rare RIPK3 Variant Enhances Necroptosis and Promotes Inflammation in a Still's Disease-like Autoinflammatory Syndrome.
This study identified a rare RIPK3 variant that enhances necroptosis and promotes inflammation in a Still's disease-like autoinflammatory syndrome. The findings suggest that this variant plays a role in the pathogenesis of autoinflammatory diseases. This research could inform genetic screening and therapeutic strategies for these conditions.
Chen L, Dai Q, Xiao Y et al. · Arthritis & rheumatology (Hoboken, N.J.) · (2026) · View on PubMed ↗
Metabolic Disease
Joint TOS/OMA/OAC expert guidance statement on the pharmacological management of United States adults with overweight or obesity using the GRADE approach.
This expert guidance statement provides updated pharmacological management recommendations for adults with overweight or obesity in the United States. It highlights the importance of evidence-based treatments and addresses barriers to obesity management. The recommendations aim to improve access to effective obesity treatments and reduce related health complications.
Alexander L, Purnell JQ, Burridge K et al. · Obesity pillars · (2026) · View on PubMed ↗
Skeletal muscle metabolism in health and disease: Mechanisms, interventions, and clinical perspectives.
This review synthesizes the mechanisms, interventions, and clinical perspectives related to skeletal muscle metabolism in health and disease. It highlights the role of metabolic flexibility in preventing metabolic diseases and discusses key regulators of muscle metabolism. Understanding these processes is crucial for developing strategies to combat conditions like obesity and sarcopenia.
Lin D, Zhang L, Huang C et al. · iScience · (2026) · View on PubMed ↗
Type 2 diabetes mellitus.
This review provides a comprehensive overview of type 2 diabetes mellitus, discussing its epidemiology, risk factors, and complications. The rising prevalence of early-onset type 2 diabetes is highlighted, emphasizing the need for targeted interventions. Understanding the complexities of T2DM is crucial for developing effective prevention and management strategies.
Davies MJ, Lim S, Slater T et al. · Nature reviews. Disease primers · (2026) · View on PubMed ↗
Adherence to the EAT-Lancet Diet and Risk of Sepsis: A Prospective Cohort Study from the UK Biobank.
This prospective cohort study examined the association between adherence to the EAT-Lancet diet and sepsis risk in a large UK Biobank population. The results indicated that higher adherence to this diet was linked to a significantly reduced risk of sepsis. This suggests that dietary interventions could play a role in sepsis prevention.
Nan W, Huang Q, He B et al. · NPJ science of food · (2026) · View on PubMed ↗
Velocity Loss During Resistance Training: Implications for Concurrent Training Adaptations.
This study investigated the effects of different velocity loss thresholds during resistance training on body composition in youth with type 1 diabetes. The results indicated that specific thresholds could optimize training outcomes, improving body composition. This research could inform exercise recommendations for this population.
Tundidor-Duque RM, Loturco I, Paéz-Maldondado JA et al. · Scandinavian journal of medicine & science in sports · (2026) · View on PubMed ↗
The relationship between sarcopenia and all-cause and cardiovascular mortality risk among middle-aged and older adults across stages 0-3 of cardiovascular-kidney-metabolic syndrome: evidence from NHANES and CHARLS.
This study examined the relationship between sarcopenia and mortality risk among middle-aged and older adults across stages of cardiovascular-kidney-metabolic syndrome. The findings indicated that sarcopenia is associated with increased mortality risk, emphasizing the need for early identification and intervention. This highlights the importance of muscle health in aging populations.
Chen Y, Liu Y, Liu S et al. · Cardiorenal medicine · (2026) · View on PubMed ↗
Gut microbe-derived N-acyl serinol lipids shape host postprandial metabolic homeostasis.
This study investigated the role of gut microbe-derived N-acyl serinol lipids in postprandial metabolic homeostasis. The findings suggest that these metabolites play a significant role in regulating metabolic responses to food. This could inform dietary interventions aimed at improving metabolic health.
Dutta S, Mahen KK, Massey WJ et al. · Proceedings of the National Academy of Sciences of the United States of America · (2026) · View on PubMed ↗
MASLD as a systemic metabolic disease: expanding the scope of cardiovascular-kidney-metabolic (CKM) syndrome.
This review discusses metabolic dysfunction-associated steatotic liver disease (MASLD) and its systemic impacts on cardiovascular and renal health. The findings emphasize the need for integrated management of MASLD in cardiology and nephrology. This highlights the importance of recognizing MASLD as a systemic metabolic disease.
Zhou XD, Fan QY, Targher G et al. · Science China. Life sciences · (2026) · View on PubMed ↗
Managing Bone Fragility in Older Adults with Diabetes: Pathophysiology, Assessment, and Therapeutic Considerations.
This review discusses the management of bone fragility in older adults with diabetes, highlighting the distinct pathophysiological mechanisms involved. The findings emphasize the need for tailored assessment and treatment strategies for this population. This research underscores the importance of addressing bone health in diabetes management.
Bahat G, Erdogan T, Ozturk S et al. · Drugs & aging · (2026) · View on PubMed ↗
Effects of Diactive-1-Supported Progressive Resistance Training on Body Composition in Youth With Type 1 Diabetes.
This study examined the effects of progressive resistance training on body composition in youth with type 1 diabetes, finding positive outcomes. The findings suggest that resistance training can improve body composition in this population. This research could inform exercise recommendations for managing diabetes in children and adolescents.
Muñoz-Pardeza J, López-Gil JF, Hormazábal-Aguayo I et al. · Journal of cachexia, sarcopenia and muscle · (2026) · View on PubMed ↗
Genomics & Genetics
Embedded CRISPRi Enhances Gene-Silencing Efficiency in Drosophila.
This research introduced embedded CRISPR interference (emCRISPRi) to enhance gene-silencing efficiency in Drosophila by integrating transcriptional repression domains into dCas9. The emCRISPRi platform significantly improved the silencing of coding genes and cis-regulatory elements. This advancement could facilitate more precise genetic studies and applications in developmental biology.
Fu P, Zhang X, Zhou Y et al. · Advanced science (Weinheim, Baden-Wurttemberg, Germany) · (2026) · View on PubMed ↗
Human DHX29 detects nonoptimal codon usage to regulate mRNA stability.
This study identified DHX29 as a regulator of mRNA stability linked to nonoptimal codon usage in human cells. The findings suggest that DHX29 plays a critical role in gene expression regulation. This could have implications for understanding translational control in various diseases.
Hia F, Wu Y, Yoshinaga M et al. · Science (New York, N.Y.) · (2026) · View on PubMed ↗
Unstructured transcription factor interactions enable emergent specificity.
The research explored how unstructured transcription factor interactions influence gene specificity and chromatin organization. The findings suggest that intrinsically disordered regions can enhance transcription factor binding to chromatin. This could inform our understanding of gene regulation mechanisms.
Abidi AA, Cattoglio C, Tang NN et al. · Science (New York, N.Y.) · (2026) · View on PubMed ↗
Neuroscience
How gut microbiota contribute to neuropsychiatric disorders: evidence from neuroimaging studies.
The review discusses the contribution of gut microbiota to neuropsychiatric disorders, emphasizing the microbiota-gut-brain axis. Neuroimaging studies reveal associations between gut microbial alterations and brain structure/function abnormalities. This highlights the potential for microbiome-targeted interventions in treating neuropsychiatric conditions.
Jia C, Zhu W, Yuan Y et al. · Frontiers in microbiology · (2026) · View on PubMed ↗
Cryo-EM structure of TRPM1 reveals a non-canonical architecture with an inverted transmembrane domain.
The study utilized cryo-EM to determine the structure of TRPM1, revealing a non-canonical architecture that could inform its function in vision. The findings suggest that TRPM1's structure may contribute to its role in light sensitivity and retinal signaling. Understanding TRPM1's structure could aid in developing therapies for vision-related disorders.
Fabrizio M, Brewer M, Bogdanović N et al. · Nature communications · (2026) · View on PubMed ↗
Hypothalamic clock governs circadian pain.
This study found that the hypothalamic clock regulates circadian pain sensitivity, with implications for chronic pain management. The research demonstrated that daily oscillations in pain thresholds are linked to hypothalamic signaling pathways. This could inform new approaches to pain treatment based on circadian rhythms.
Wei HR, Lou Q, Li LX et al. · Science (New York, N.Y.) · (2026) · View on PubMed ↗
From chronic pain to depression: Neurogenesis-driven microglial remodeling in the hippocampal dentate gyrus.
This research explored the link between chronic pain and depression, identifying neurogenesis-driven microglial remodeling in the hippocampus. The findings suggest that pain-induced changes in the hippocampus may contribute to affective disorders. This highlights the need for integrated approaches to pain and mental health treatment.
Ding M, Xiang S, Zhang Y et al. · Science (New York, N.Y.) · (2026) · View on PubMed ↗
Astrocytes at the crossroads of obstructive sleep apnea and Alzheimer's disease: from oxygen sensing to neurodegeneration.
The review discusses the role of astrocytes in linking obstructive sleep apnea and Alzheimer's disease, highlighting their potential as therapeutic targets. The findings suggest that astrocytes may mediate the effects of sleep disturbances on neurodegeneration. This research underscores the importance of addressing sleep disorders in Alzheimer's disease management.
Cabot J, Soriano JB, Alonso-Fernández A et al. · Sleep & breathing = Schlaf & Atmung · (2026) · View on PubMed ↗
Interplay of oxidative stress and neuroinflammation in alzheimer's: insights into age-driven pathogenesis.
This review explores the interplay of oxidative stress and neuroinflammation in Alzheimer's disease, focusing on age-driven pathogenesis. The findings suggest that targeting oxidative stress could be a therapeutic strategy for AD. This research highlights the complex mechanisms underlying neurodegeneration.
Firdous SM, Chakrabortty S, Undale VR et al. · Inflammopharmacology · (2026) · View on PubMed ↗
Therapeutic Potential of Somatostatin and Its Analogues in Alzheimer's Disease: From Molecular Mechanisms to Preclinical Studies.
This review discusses the therapeutic potential of somatostatin and its analogues in Alzheimer's disease, highlighting their multitarget effects. The findings suggest that somatostatin could modulate key pathological processes in AD. This research underscores the need for novel therapeutic approaches in neurodegenerative diseases.
Liu K, Zhang XY, Wang YT et al. · Molecular neurobiology · (2026) · View on PubMed ↗
Machine Learning-Based Sleep Electroencephalographic Brain Age Index and Dementia Risk: An Individual Participant Data Meta-Analysis.
This meta-analysis examined the association between sleep electroencephalographic brain age index and dementia risk, revealing significant correlations. The findings suggest that sleep EEG patterns could serve as biomarkers for dementia risk assessment. This research highlights the potential for sleep studies in cognitive health monitoring.
Sun H, Milton S, Fang Y et al. · JAMA network open · (2026) · View on PubMed ↗
Transcriptomic Insights Into Alzheimer's Disease: Differentially Expressed Genes and Cholesterol Metabolism.
This study explored the differential expression of genes related to cholesterol metabolism in Alzheimer's disease, highlighting potential biomarkers for early detection. The findings suggest that targeting cholesterol metabolism could be a therapeutic strategy for AD. This research contributes to understanding the metabolic aspects of neurodegeneration.
Sun R, Wang X, Wang Z et al. · CNS neuroscience & therapeutics · (2026) · View on PubMed ↗
Phospholipid Glutathione Peroxidase Overexpression Mitigates Cancer Cachexia by Protecting Muscle Mass and Lowering Inflammation.
This study found that early-life melatonin supplementation reduces behavioral and molecular alterations in a rat model of autism spectrum disorder. The findings suggest that melatonin may have protective effects on neurodevelopment. This research highlights the potential for melatonin as a therapeutic option in ASD.
Duggan E, Fuqua JD, Hagy B et al. · Journal of cachexia, sarcopenia and muscle · (2026) · View on PubMed ↗
Endocrinology
Glucagon-like peptide-1 receptor agonists for major cardiovascular and kidney outcomes in type 1 diabetes.
This study assessed the long-term cardiovascular and kidney outcomes of glucagon-like peptide-1 receptor agonists in patients with type 1 diabetes using national health records. The findings indicated that GLP-1RA initiation was associated with lower risks of major adverse cardiovascular events and end-stage kidney disease. This suggests that GLP-1RAs could be beneficial in managing cardiovascular and renal complications in type 1 diabetes.
Xu Y, Malek ND, Chang AR et al. · Nature medicine · (2026) · View on PubMed ↗
Proteomic analyses of human islets reveal potential markers of β-cell dysfunction during prediabetes.
This study utilized proteomic analyses to identify markers of β-cell dysfunction during prediabetes. The findings suggest that specific protein changes could predict diabetes onset. This research could inform early intervention strategies for preventing type 2 diabetes.
Cefalo CMA, Mezza T, Quero G et al. · JCI insight · (2026) · View on PubMed ↗
Infectious Disease
LRP8 is a functional receptor for yellow fever virus.
This research identified LRP8 as a functional receptor for yellow fever virus, enhancing our understanding of viral entry mechanisms. The study demonstrated that LRP8 promotes infection by facilitating viral entry in cell lines. This knowledge could inform vaccine development and therapeutic strategies against yellow fever virus.
Mei M, Yang Y, Zhang Z et al. · Nature microbiology · (2026) · View on PubMed ↗
ALG6 orchestrates coronavirus replication via the endoplasmic reticulum stress-autophagy axis.
This study identified ALG6 as a host factor essential for coronavirus replication via the endoplasmic reticulum stress-autophagy axis. The findings suggest that targeting ALG6 could inhibit viral replication. This research provides insights into potential therapeutic strategies against coronaviruses.
Fu Y, Gao M, Fu Z et al. · Cell reports · (2026) · View on PubMed ↗
Association between COVID-19 vaccination and sudden death in apparently healthy younger individuals: A population-based case-control study.
The study examined the association between COVID-19 vaccination and sudden death in younger individuals, finding no significant link. This research addresses public concerns regarding vaccine safety in healthy populations. The findings contribute to the ongoing evaluation of vaccine safety profiles.
Abdel-Qadir H, Bhatt HA, Swayze S et al. · PLoS medicine · (2026) · View on PubMed ↗
Gastroenterology
CD177⁺ neutrophil-platelet aggregates contribute to thromboinflammation via NETs in necrotizing enterocolitis.
This study identified CD177⁺ neutrophil-platelet aggregates as contributors to thromboinflammation in necrotizing enterocolitis (NEC). The findings highlight the role of immunothrombosis in NEC pathogenesis, suggesting potential therapeutic targets. This research could lead to improved management strategies for NEC in premature infants.
Lan C, Tian B, Shi Y et al. · Nature communications · (2026) · View on PubMed ↗
Host-derived nitrate fuels indole production by Escherichia coli to drive chronic kidney disease progression.
The study investigated how host-derived nitrate fuels indole production by E. coli, contributing to chronic kidney disease progression. The findings suggest that microbial metabolism plays a role in CKD, highlighting the gut-kidney axis. This could inform therapeutic strategies targeting microbiota in CKD management.
Lee JY, Mahan SP, Parente de Carvalho T et al. · Science (New York, N.Y.) · (2026) · View on PubMed ↗
ECM1 produced by hepatic stellate cells serves as gate keeper of liver homeostasis in hepatic fibrosis.
This study examined the role of ECM1 produced by hepatic stellate cells in liver homeostasis and fibrosis. The findings suggest that ECM1 is crucial for maintaining liver health and could be a therapeutic target in liver diseases. This research underscores the importance of understanding cellular interactions in liver pathology.
Yang A, Yan X, Wang Y et al. · Hepatology (Baltimore, Md.) · (2026) · View on PubMed ↗
Respiratory Medicine
Clinical practice guideline for long COVID prevention and treatment.
This clinical practice guideline addresses long COVID prevention and treatment, providing evidence-based recommendations for healthcare providers. The guideline emphasizes the importance of a multidisciplinary approach in managing long COVID symptoms. This resource aims to enhance care for patients suffering from long COVID.
Cao B, Soriano JB, Wang Q et al. · The European respiratory journal · (2026) · View on PubMed ↗
Epidemiology, ventilation, and outcomes of acute respiratory failure in immunocompromised patients from 103 intensive care units in 26 countries: a retrospective observational study.
This retrospective observational study examined acute respiratory failure in immunocompromised patients across 103 ICUs in 26 countries. The study identified predictors of mortality and intubation, providing valuable insights into managing ARF in this vulnerable population. These findings could inform clinical practices and improve patient outcomes.
Azoulay E, McEvoy C, Castro P et al. · The Lancet. Respiratory medicine · (2026) · View on PubMed ↗
Psychiatry
The efficacy and safety of cannabinoids for the treatment of mental disorders and substance use disorders: a systematic review and meta-analysis.
This systematic review and meta-analysis evaluated the efficacy and safety of cannabinoids for treating mental disorders and substance use disorders. The findings indicate mixed results regarding their effectiveness, underscoring the need for further research. This highlights the complexity of using cannabinoids in psychiatric treatment.
Wilson J, Dobson O, Langcake A et al. · The lancet. Psychiatry · (2026) · View on PubMed ↗
Orthopedics
FGF21-Mediated Upregulation of SIRT1 Delays Intervertebral Disc Degeneration by Promoting PINK1/Parkin Dependent Mitophagy Through Deacetylation of FOXO3.
The study explored the role of FGF21 in delaying intervertebral disc degeneration (IDD) by promoting mitophagy through SIRT1 upregulation. FGF21 was found to be downregulated in degenerated discs, correlating with senescence markers and clinical features. This suggests that FGF21 could be a potential therapeutic target for preventing IDD and associated back pain.
Wu ZL, Ran R, Xie QQ et al. · Aging cell · (2026) · View on PubMed ↗
Apoptotic extracellular vesicles derived from MSCs exposed to hypoxic and inflammatory environments slow intervertebral disc degeneration by enhancing cell activity and regulating immunity microenvironment.
The study demonstrated that apoptotic extracellular vesicles from mesenchymal stem cells exposed to hypoxic and inflammatory environments can slow intervertebral disc degeneration by enhancing cell activity and modulating the immune microenvironment. This suggests a potential therapeutic application of stem cell-derived vesicles in treating degenerative disc diseases. The findings could lead to innovative strategies for managing intervertebral disc degeneration.
Zhang W, Ma X, Yin H et al. · Materials today. Bio · (2026) · View on PubMed ↗
Disruption of iron homeostasis by HERC2-FTL axis leads to chondrocyte loss and exacerbates osteoarthritis.
This study investigated the role of iron homeostasis disruption in osteoarthritis progression, identifying the HERC2-FTL axis as a key regulator. The findings suggest that targeting this axis could mitigate cartilage loss and inflammation. This research highlights potential therapeutic strategies for osteoarthritis management.
Zhong Y, Duan J, Chen Z et al. · Apoptosis : an international journal on programmed cell death · (2026) · View on PubMed ↗
Dermatology
Psoriasis modulates inflammatory bowel disease risk and intestinal epithelium lipid metabolism via IL-1β-producing macrophages.
The study investigated the relationship between psoriasis and inflammatory bowel disease risk, revealing that psoriasis severity correlates with impaired intestinal lipid metabolism. This suggests that psoriasis may influence gut health and increase the risk of developing inflammatory bowel disease. Understanding this link could inform management strategies for patients with psoriasis.
Wu J, Liu S, Dan W et al. · Cell metabolism · (2026) · View on PubMed ↗
A neuroimmune circuit links stress to skin inflammation.
This study identified a neuroimmune circuit linking stress to skin inflammation, specifically in atopic dermatitis. The findings suggest that sympathetic neurons activate eosinophils during stress, exacerbating inflammation. This could inform new therapeutic approaches for managing stress-related skin conditions.
Gaudenzio N, Basso L · Science (New York, N.Y.) · (2026) · View on PubMed ↗
A sympathetic-eosinophil axis orchestrates psychological stress to exacerbate skin inflammation.
The study identified a sympathetic-eosinophil axis that exacerbates skin inflammation during psychological stress. The findings suggest that targeting this axis could mitigate stress-induced dermatitis. This research provides insights into the neuroimmune interactions affecting skin health.
Tian J, Cao Y, Li Y et al. · Science (New York, N.Y.) · (2026) · View on PubMed ↗
Ritlecitinib for Severe Alopecia Areata: A 24-Week, Multicentre, Real-World Study.
This study evaluated the effectiveness of ritlecitinib for treating severe alopecia areata in a real-world setting. The findings indicate that ritlecitinib is effective and well-tolerated in clinical practice. This adds to the evidence supporting the use of targeted therapies in alopecia areata.
Starace M, Rapparini L, Pampaloni F et al. · American journal of clinical dermatology · (2026) · View on PubMed ↗
International Dermoscopy Society consensus recommendations for the management of lentigo maligna.
This review discusses the management of lentigo maligna, providing consensus recommendations for clinicians. The findings emphasize the need for evidence-based strategies in diagnosing and treating this challenging condition. This research aims to improve care for patients with lentigo maligna.
Forsea AM, Pampena R, Akay BN et al. · Journal of the European Academy of Dermatology and Venereology : JEADV · (2026) · View on PubMed ↗
Biotechnology
Effectiveness of Al-Assisted Patient Health Education Using Voice Cloning and ChatGPT: Prospective Randomized Controlled Trial.
This study evaluated the effectiveness of AI-assisted patient education using voice cloning and ChatGPT in improving patient knowledge and treatment adherence. The results indicated that AI-driven education significantly enhanced patient engagement compared to traditional methods. This highlights the potential of AI technologies in personalized healthcare education.
Sun Y, Xu S, Jin H et al. · Journal of medical Internet research · (2026) · View on PubMed ↗
Commensal-driven serotonin production modulates in vivo delivery of synthetic and viral vectors.
The research identified that gut microbiota influence the delivery efficiency of synthetic and viral vectors in vivo through serotonin production. Disrupting commensal-host interactions improved drug delivery outcomes. This suggests that microbiome modulation could enhance the effectiveness of therapeutic delivery systems.
Wang Q, Chen Z, Zhang G et al. · Science (New York, N.Y.) · (2026) · View on PubMed ↗
Resetting of a tandem microRNA156 enables vegetative perennial growth in rice.
This study explored the genetic mechanisms underlying perennial growth in rice, identifying the EBT1 locus responsible for this trait. The findings suggest that manipulating this locus could enhance rice cultivation practices. This research has implications for agricultural biotechnology and crop improvement.
Dai B, Lv D, Chen E et al. · Science (New York, N.Y.) · (2026) · View on PubMed ↗
Phase separation of Rht8-derived RNHL1 integrates ethylene and gibberellin signaling to regulate wheat internode elongation.
This study examined the roles of Rht8-derived RNHL1 in regulating wheat internode elongation through phase separation mechanisms. The findings suggest that RNHL1 interacts with ethylene signaling to control plant growth. This research has implications for agricultural biotechnology and crop improvement.
Dong C, Cheng X, Yuan M et al. · The Plant cell · (2026) · View on PubMed ↗
Other
Efficacy and Safety of Remimazolam Tosylate versus Propofol for Sedation of Postoperative Mechanically Ventilated Patients in Intensive Care Units: a Multicenter, Randomized, Single-blind, Non-inferiority, Phase 3 trial.
This phase 3 trial compared remimazolam tosylate to propofol for sedation in mechanically ventilated patients in ICUs. The findings demonstrated that remimazolam was non-inferior in safety and effectiveness, suggesting it as a viable alternative for sedation. This could improve sedation practices in critical care settings.
Meat Consumption and Cognitive Health by APOE Genotype.
This study examined the relationship between meat consumption and cognitive health by APOE genotype, finding that higher meat intake may benefit cognitive health in certain genotypes. The findings suggest that dietary recommendations could be tailored based on genetic risk factors for Alzheimer's disease. This research underscores the importance of personalized nutrition in cognitive health.
Identification and Validation of miR-206-3p Targeting WT-1 Promotes Membranous Nephropathy Through a Comprehensive Bioinformatics and Machine Learning Algorithm.
This study identified and validated miR-206-3p as a promoter of membranous nephropathy through bioinformatics and machine learning approaches. The findings suggest that targeting this microRNA could offer new therapeutic avenues for treating membranous nephropathy. This research highlights the potential of precision medicine in kidney disease management.
The relationship between dietary patterns and neuroinflammation.
This review discusses the relationship between dietary patterns and neuroinflammation, emphasizing the role of nutrition in CNS health. The findings suggest that specific dietary choices could modulate neuroinflammatory responses. This research highlights the potential for dietary interventions in preventing neurodegenerative diseases.
Generated automatically on March 21, 2026 from PubMed's trending articles. Summaries are AI-generated; always consult the original publication for clinical or research decisions.